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Journal of Veterinary Internal Medicine

Lisa R Bartner, Stephanie McGrath, Adam Drury, Annie V Chen, Arianne Morris, Melissa Brewer, Meri Hall, Michael R Lappin
BACKGROUND: Neurobartonellosis occurs in people. The role these organisms might play in inflammatory brain disease of dogs is unclear. HYPOTHESIS/OBJECTIVES: That Bartonella spp. DNA would be amplified more commonly from the CSF of dogs with inflammatory disease compared to those with noninflammatory disease. To report the prevalence of Bartonella spp. in dogs with and without inflammatory CNS disease with a commercially available PCR assay. ANIMALS: Cerebrospinal fluid (CSF) samples from 172 dogs from either Washington State University or Colorado State University...
October 31, 2018: Journal of Veterinary Internal Medicine
Stanley L Marks, Peter H Kook, Mark G Papich, M Katherine Tolbert, Michael D Willard
The gastrointestinal (GI) mucosal barrier is continuously exposed to noxious toxins, reactive oxygen species, microbes, and drugs, leading to the development of inflammatory, erosive, and ultimately ulcerative lesions. This report offers a consensus opinion on the rational administration of GI protectants to dogs and cats, with an emphasis on proton pump inhibitors (PPIs), histamine type-2 receptor antagonists (H2 RAs), misoprostol, and sucralfate. These medications decrease gastric acidity or promote mucosal protective mechanisms, transforming the management of dyspepsia, peptic ulceration, and gastroesophageal reflux disease...
October 31, 2018: Journal of Veterinary Internal Medicine
Natalie C Finch, Harriet M Syme, Jonathan Elliott
BACKGROUND: Estimated glomerular filtration rate (eGFR) formulas are routinely used in human patients to provide a more accurate evaluation of GFR compared to serum creatinine concentration alone. Similar formulas do not exist for cats. OBJECTIVES: To validate a prediction formula for eGFR in cats based on adjusting serum creatinine concentration. ANIMALS: Client-owned cats with various levels of renal function. METHODS: The study was cross-sectional...
October 30, 2018: Journal of Veterinary Internal Medicine
Miriely S Diniz, Francisco J Teixeira-Neto, Daniele S Gonçalves, Nathalia Celeita-Rodríguez, Carolina H Girotto, Mariana W Fonseca, Regina K Takahira
BACKGROUND: Tetrastarch solution (TS) can impair coagulation but the clinical relevance of this impairment is unclear in veterinary medicine. OBJECTIVE: Compare the effects of volume replacement (VR) with lactated Ringer's solution (LRS) or 6% TS on coagulation in hemorrhaged dogs. ANIMALS: Six healthy English Pointer dogs (19.7-35.3 kg). METHODS: Prospective crossover study. Dogs were anesthetized without hemorrhage and VR (control)...
October 25, 2018: Journal of Veterinary Internal Medicine
M J Mattin, A Boswood, D B Church, D C Brodbelt
BACKGROUND: Prognostic risk factors were identified for dogs with degenerative mitral valve disease (DMVD) monitored by veterinary cardiologists. The value of these measurements has not been determined in the wider primary care setting. OBJECTIVES: To evaluate whether plasma cardiac biomarkers and data obtained from routine history-taking and physical examination are predictive of survival in dogs with DMVD attending primary care practice. ANIMALS: Eight-hundred and ninety-three dogs with a presumptive diagnosis of DMVD recruited from 79 primary care veterinary practices in the United Kingdom...
October 24, 2018: Journal of Veterinary Internal Medicine
Rachel L Kovac, Gregory Ballash, Joelle Fenger, Cheryl London, Emma Warry
BACKGROUND: No biomarkers for the early detection of gastrointestinal (GI) toxicosis secondary to antineoplastic treatment are recognized in veterinary medicine. Toceranib causes GI toxicosis in dogs. HYPOTHESIS/OBJECTIVE: To assess if changes in plasma cytokeratin 18 (CK18) concentration, measured in dogs being treated with toceranib phosphate, can predict the onset of GI toxicosis. We hypothesize that an increase in CK18 concentrations will be detected before the development of GI toxicosis in dogs treated with toceranib phosphate...
October 24, 2018: Journal of Veterinary Internal Medicine
Mark J Acierno, Scott Brown, Amanda E Coleman, Rosanne E Jepson, Mark Papich, Rebecca L Stepien, Harriet M Syme
An update to the 2007 American College of Veterinary Internal Medicine (ACVIM) consensus statement on the identification, evaluation, and management of systemic hypertension in dogs and cats was presented at the 2017 ACVIM Forum in National Harbor, MD. The updated consensus statement is presented here. The consensus statement aims to provide guidance on appropriate diagnosis and treatment of hypertension in dogs and cats.
October 24, 2018: Journal of Veterinary Internal Medicine
Emily Schaefer, Corey Harms, Molly Viner, Samantha Barnum, Nicola Pusterla
BACKGROUND: Equine coronavirus (ECoV) is a recently reported enteric disease of adult horses. Natural infection by ECoV has been reported in adult horses worldwide, whereas experimental infection has only been reported in juvenile horses. An experimental infection model is needed to study the clinical presentation, laboratory abnormalities, and pathophysiological changes associated with ECoV. OBJECTIVES: To investigate the clinical, hematologic, molecular, and serological features of adult horses experimentally infected with ECoV...
October 24, 2018: Journal of Veterinary Internal Medicine
Francesca Bresciani, Yasushi Minamoto, Jan S Suchodolski, Giorgia Galiazzo, Carla G Vecchiato, Carlo Pinna, Giacomo Biagi, Marco Pietra
BACKGROUND: Dietary interventions are thought to modify gut microbial communities in healthy individuals. In dogs with chronic enteropathies, resolution of dysbiosis, along with remission of clinical signs, is expected with treatment. HYPOTHESIS/OBJECTIVE: To evaluate changes in the fecal microbiota in dogs with food-responsive chronic enteropathy (FRE) and in healthy control (HC) dogs before and after an elimination dietary trial with an animal protein-free diet (APFD)...
October 23, 2018: Journal of Veterinary Internal Medicine
Ran Nivy, Kent R Refsal, Ella Ariel, Sharon Kuzi, Einat Yas-Natan, Michal Mazaki-Tovi
BACKGROUND: Current recommendation for performing the ACTH stimulation test (ACTHST) for diagnosis of hyperadrenocorticism (HAC) advocates the collection of baseline serum cortisol concentration (BC), but no references for interpretation of its results exist. OBJECTIVE: Evaluate the contribution of BC of the ACTHST to the diagnosis of HAC. ANIMALS: Fifty-four dogs were evaluated for suspected HAC at a referral hospital. METHODS: Records of dogs that had been evaluated by ACTHST for suspected HAC were reviewed...
October 18, 2018: Journal of Veterinary Internal Medicine
Wendy A Morré, David L Panciera, Gregory B Daniel, William E Monroe, Stephen Werre
BACKGROUND: Radioiodine is the treatment of choice for hyperthyroidism in cats. The ideal method of dose determination of radioiodine remains controversial. OBJECTIVE: To compare a method of radioiodine dose determination that utilized thyroid scintigraphy with a standard fixed dose for treatment of hyperthyroidism. ANIMALS: Fifty-seven and 23 client-owned hyperthyroid cats in the variable and fixed dose groups, respectively. METHODS: Cats with a percent dose uptake using 99m Tc-pertechnetate uptake on thyroid scintigraphy <5%, 5%-10%, and >10% were to receive 3, 3...
October 17, 2018: Journal of Veterinary Internal Medicine
Adriana Czerwik, Marta Płonek, Przemyslaw Podgórski, Marcin Wrzosek
BACKGROUND: In humans, temporal lobe epilepsy (TLE), is a type of focal epilepsy occurring mainly in the mesial TLE (mTLE), commonly associated with hippocampal sclerosis (HS). OBJECTIVES: According to recent studies, TLE might also occur in dogs and could be associated with hippocampal atrophy (HA)/HS. To date, hippocampal lesions have not been correlated with electroencephalographic (EEG) findings in epileptic dogs. ANIMALS: An EEG examination, brain magnetic resonance imaging, and volumetric assessment of the hippocampus were performed in 16 nonepileptic and 41 epileptic dogs...
October 16, 2018: Journal of Veterinary Internal Medicine
Sue Foster
No abstract text is available yet for this article.
October 16, 2018: Journal of Veterinary Internal Medicine
Clara Ballber, Tracy L Hill, Nick X Bommer
BACKGROUND: Sino-nasal aspergillosis is a common nasal disease in dogs. Recommended treatment protocols typically involve trephination of the frontal sinuses or the use of an antifungal solution instilled into the frontal sinus under anesthesia, both of which have associated morbidity and complications. OBJECTIVES: To assess a minimally-invasive topical treatment protocol for sino-nasal aspergillosis in dogs. ANIMALS: Twelve client-owned dogs diagnosed with sino-nasal aspergillosis that completed recommended treatment...
October 16, 2018: Journal of Veterinary Internal Medicine
Adam J Rudinsky, Laura M Harjes, Julie Byron, Dennis J Chew, Ramiro E Toribio, Catherine Langston, Valerie J Parker
BACKGROUND: Chronic kidney disease (CKD) is associated with morbidity and mortality in dogs. Plasma fibroblast growth factor-23 (FGF-23) concentration is an independent predictor of CKD progression and survival in cats and people with CKD. OBJECTIVES: To investigate the relationship among FGF-23, parathyroid hormone (PTH), vitamin D metabolites, and other clinical variables with survival time in dogs with CKD. ANIMALS: Twenty-seven azotemic CKD dogs...
October 16, 2018: Journal of Veterinary Internal Medicine
Lisa Moses, Monica J Malowney, Jon Wesley Boyd
BACKGROUND: Concerns about ethical conflicts, moral distress, and burnout in veterinary practice are steadily increasing. Root causes of these problems have not been rigorously identified. Little research has been done to evaluate the existence of moral distress in North American veterinarians or to explore its impact on career sustainability and poor well-being. HYPOTHESIS/OBJECTIVES: Ethical conflict and resultant moral distress are common occurrences in contemporary veterinary practice and negatively impact daily practice life, but may not be identified or labeled by veterinarians as such...
October 15, 2018: Journal of Veterinary Internal Medicine
Amy E Oberstadt, Nathan C Nelson, Andrew K Claude, Kent R Refsal, J Catharine Scott-Moncrieff, Brian K Petroff, Daniel K Langlois
BACKGROUND: Radioactive iodine therapy is considered the treatment of choice for hyperthyroidism in cats, but the availability of this modality is limited by costs and hospitalization requirements. Administration of recombinant human thyroid stimulating hormone (rh-TSH) to humans with thyroid neoplasia or nodular goiter can increase thyroidal iodine uptake, thereby allowing the use of lower radioactive iodine doses for treatment. Veterinary studies of this subject are limited, and results are conflicting...
October 13, 2018: Journal of Veterinary Internal Medicine
Ran Nivy, Alina Kaplanov, Sharon Kuzi, Michal Mazaki-Tovi, Einat Yas, Gilad Segev, Jennifer Ben-Oz, Eran Lavy, Itamar Aroch
BACKGROUND: Pancreatitis in cats (FP) has been increasingly diagnosed in recent years, but clinical studies of large numbers of affected cats are scarce. OBJECTIVES: To describe a large cohort of cats with FP requiring hospitalization. ANIMALS: One hundred and fifty-seven client-owned cats. METHODS: Retrospective study, including cats diagnosed with pancreatitis based on sonographic evidence, positive SNAP feline pancreatic lipase immunoreactivity test results, increased 1,2-o-dilauryl-rac-glycerol-glutaric Acid-(6'-methylresorufin ester)-lipase activity, histopathology, or some combination of these...
October 13, 2018: Journal of Veterinary Internal Medicine
Hélène Vandenberghe, Catherine Escriou, Marco Rosati, Laura Porcarelli, Alfredo Recio Caride, Sonia Añor, Gualtiero Gandini, Daniele Corlazzoli, Jean-Laurent Thibaud, Kaspar Matiasek, Stéphane Blot
BACKGROUND: The only hereditary neurologic disorder described so far in American Staffordshire Terriers is adult-onset cerebellar degeneration secondary to ceroid lipofuscinosis. We have seen several dogs with a newly recognized neurological disease characterized by locomotor weakness with or without respiratory signs and juvenile onset consistent with degenerative polyneuropathy of genetic origin. OBJECTIVES: To characterize a novel polyneuropathy in juvenile American Staffordshire Terriers...
October 13, 2018: Journal of Veterinary Internal Medicine
Megan Conroy, Yu-Mei Chang, Dave Brodbelt, Jonathan Elliott
BACKGROUND: Hypertension is common in older cats. There is limited evidence for predictors of survival after diagnosis. HYPOTHESIS/OBJECTIVES: Investigate blood pressure assessment (BPA) and hypertension diagnosis in cats attending UK primary care practices (PCPs) and factors that influence survival. ANIMALS: Cats (347 889) attending 244 UK PCPs enrolled in the VetCompass program between January 1, 2012, and December 31, 2013. Cats identified as hypertensive (282) were included in descriptive and survival analyses...
October 13, 2018: Journal of Veterinary Internal Medicine
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