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Journal of Veterinary Internal Medicine

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https://www.readbyqxmd.com/read/29782043/stereotactic-radiation-therapy-for-the-treatment-of-functional-pituitary-adenomas-associated-with-feline-acromegaly
#1
Tiffany L Wormhoudt, Mary-Keara Boss, Katharine Lunn, Lynn Griffin, Del Leary, Kristy Dowers, Sangeeta Rao, Susan M LaRue
BACKGROUND: Conventional fractionated radiotherapy has been shown to be partially effective for management of pituitary tumors in cats that cause acromegaly and diabetes mellitus (DM), but, the efficacy and safety of stereotactic radiation therapy (SRT) as a treatment for acromegalic cats has not been described. HYPOTHESIS: Stereotactic radiation therapy is an effective and safe treatment for controlling acromegaly associated with pituitary adenomas in cats. Additionally, SRT-treated acromegalic cats with DM will experience a decrease in insulin requirements after radiation therapy...
May 21, 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29770976/pharmacokinetic-and-pharmacodynamic-properties-of-orally-administered-torsemide-in-healthy-horses
#2
Gustavo F Agne, Seung Woo Jung, Anne A Wooldridge, Susan H Duran, William Ravis, Ramiro Toribio
BACKGROUND: Diuretic treatment is the mainstay for management of congestive heart failure in horses, and its use has been restricted to injectable medications because no currently data supports the use of PO administered loop diuretics. OBJECTIVES: To determine the pharmacokinetic and pharmacodynamic properties of PO administered torsemide and, determine if PO administered torsemide, could be used as an alternative to injectable diuretics in the horse. ANIMALS: Six healthy adult mares...
May 17, 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29770973/genome-wide-based-model-predicting-recovery-from-portosystemic-shunting-after-liver-shunt-attenuation-in-dogs
#3
Lindsay Van den Bossche, Frank G van Steenbeek, Maarten F Weber, Bart Spee, Louis C Penning, Freek J van Sluijs, Flin Zomerdijk, Marian J A Groot Koerkamp, Jan Rothuizen, Iwan A Burgener, Anne Kummeling
BACKGROUND: In dogs with congenital portosystemic shunt (CPSS), recovery after surgical CPSS attenuation is difficult to predict. OBJECTIVES: Our aim was to build a model with plasma albumin concentration and mRNA expression levels of hepatic gene products as predictors of recovery from portosystemic shunting after surgery. ANIMALS: Seventy-three client-owned dogs referred for surgical attenuation of CPSS. METHODS: A prediction model was constructed using 2 case-control studies of recovered and nonrecovered dogs after surgical CPSS attenuation...
May 17, 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29770972/fractional-excretion-of-electrolytes-in-volume-responsive-and-intrinsic-acute-kidney-injury-in-dogs-diagnostic-and-prognostic-implications
#4
Roberta Troìa, Marta Gruarin, Chiara Grisetti, Federica Serafini, Luca Magna, Erika Monari, Massimo Giunti, Francesco Dondi
BACKGROUND: The value of fractional excretion (FE) of electrolytes to characterize and prognosticate acute kidney injury (AKI) is poorly documented in dogs. OBJECTIVES: To evaluate the diagnostic and prognostic roles of FE of electrolytes in dogs with AKI. ANIMALS: Dogs (n = 135) with AKI treated with standard care (February 2014-December 2016). METHODS: Prospective study. Clinical and laboratory variables including FE of electrolytes, were measured upon admission...
May 17, 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29761571/frequency-of-shedding-of-respiratory-pathogens-in-horses-recently-imported-to-the-united-states
#5
Fauna Leah Smith, Johanna L Watson, Sharon J Spier, Isabelle Kilcoyne, Samantha Mapes, Claudia Sonder, Nicola Pusterla
BACKGROUND: Imported horses that have undergone recent long distance transport might represent a serious risk for spreading infectious respiratory pathogens into populations of horses. OBJECTIVE: To investigate the frequency of shedding of respiratory pathogens in recently imported horses. ANIMALS: All imported horses with signed owner consent (n = 167) entering a USDA quarantine for contagious equine metritis from October 2014 to June 2016 were enrolled in the study...
May 15, 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29749656/establishment-of-reference-values-of-the-caudal-vena-cava-by-fast-ultrasonography-through-different-views-in-healthy-dogs
#6
Elodie Darnis, Soren Boysen, Anne-Christine Merveille, Loïc Desquilbet, Serge Chalhoub, Kris Gommeren
BACKGROUND: Clinical assessment of intravascular volume status is challenging. In humans, ultrasonographic assessment of the inferior vena cava diameter, directly or as a ratio to the aortic diameter is used to estimate intravascular volume status. OBJECTIVES: To ultrasonographically obtain reference values (RV) for caudal vena cava diameter (CVCD ), area (CVCa ) and aortic ratios using 3 views in awake healthy dogs. ANIMALS: One hundred and twenty-six healthy adult dogs from clients, students, faculty, or staff...
May 10, 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29749651/effects-of-immunosuppressive-agents-on-the-hemostatic-system-in-normal-dogs
#7
John M Thomason, Todd M Archer, Robert W Wills, Andrew J Mackin
BACKGROUND: In dogs, the effects of immunosuppressive medications on hemostasis are not well known. HYPOTHESIS/OBJECTIVES: The objective was to determine the effects of immunosuppressive medications on primary and secondary hemostasis. Our hypothesis was that cyclosporine and prednisone would increase markers of hypercoagulability and thromboxane synthesis, while azathioprine, mycophenolate mofetil, and leflunomide would have minimal effects on hemostasis. ANIMALS: Eight healthy dogs...
May 10, 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29749643/insulin-dysregulation-in-horses-with-systemic-inflammatory-response-syndrome
#8
François-René Bertin, Debra Ruffin-Taylor, Allison Jean Stewart
BACKGROUND: Systemic inflammation is a cause of insulin dysregulation in many species, but the insulin and glucose dynamics in adult horses diagnosed with systemic inflammatory response syndrome (SIRS) are poorly documented. HYPOTHESIS/OBJECTIVES: In SIRS in horses, insulin and glucose dynamics will be altered and associated with survival. ANIMALS: Adult horses diagnosed with SIRS admitted to a referral hospital. METHODS: Prospective study enrolling horses diagnosed with SIRS in which serum insulin and glucose concentrations were measured...
May 10, 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29749082/effect-of-induced-chronic-atrial-fibrillation-on-exercise-performance-in-standardbred-trotters
#9
Rikke Buhl, Helena Carstensen, Eva Zander Hesselkilde, Bjørg Zinkernagel Klein, Karen Margrethe Hougaard, Kirsten Bomberg Ravn, Ameli Victoria Loft-Andersen, Merle Friederike Fenner, Christian Pipper, Thomas Jespersen
BACKGROUND: Atrial fibrillation (AF) is the most common arrhythmia affecting performance in horses. However, no previous studies have quantified the performance reduction in horses suffering from AF. OBJECTIVES: To quantify the effect of AF on maximum velocity (Vmax ), maximum heart rate (HRmax ), heart rate recovery (T100 ), hematologic parameters and development of abnormal QRS complexes. ANIMALS: Nine Standardbred trotters. METHODS: Two-arm controlled trial...
May 10, 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29736988/use-of-basal-and-trh-stimulated-plasma-growth-hormone-concentrations-to-differentiate-between-primary-hypothyroidism-and-nonthyroidal-illness-in-dogs
#10
Tera Pijnacker, Hans S Kooistra, Cathelijne F Vermeulen, Merel van der Vinne, Marrit Prins, Sara Galac, Jan A Mol
BACKGROUND: A low plasma total thyroxine (TT4 ) concentration in combination with a plasma TSH concentration within reference range does not distinguish between hypothyroidism and nonthyroidal illness (NTI) in dogs. Hypothyroidism is associated with TSH-releasing hormone (TRH)-induced increased release of growth hormone (GH). HYPOTHESIS: Basal and TRH-induced plasma GH concentrations can be used to distinguish hypothyroid dogs from NTI dogs. ANIMALS: Twenty-one dogs with signs consistent with hypothyroidism, a low plasma TT4 concentration, and a plasma TSH concentration within reference interval...
May 7, 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29704284/prognostic-importance-of-plasma-total-magnesium-in-a-cohort-of-cats-with-azotemic-chronic-kidney-disease
#11
D Hendrik N van den Broek, Yu-Mei Chang, Jonathan Elliott, Rosanne E Jepson
BACKGROUND: Hypomagnesemia is associated with increased mortality and renal function decline in humans with chronic kidney disease (CKD). Magnesium is furthermore inversely associated with fibroblast growth factor 23 (FGF23), an important prognostic factor in CKD in cats. However, the prognostic significance of plasma magnesium in cats with CKD is unknown. OBJECTIVES: To explore associations of plasma total magnesium concentration (tMg) with plasma FGF23 concentration, all-cause mortality, and disease progression in cats with azotemic CKD...
April 27, 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29704274/saccadic-oscillations-in-4-dogs-and-1-cat
#12
Edward J Ives, Edward MacKillop, Natasha J Olby
Disorders affecting the control of saccadic eye movements result in involuntary saccadic oscillations and are widely reported in human medicine. Information regarding the occurrence and potential importance of saccadic oscillations in veterinary medicine is currently limited. The clinical histories of three dogs and one cat displaying involuntary eye movements consistent with opsoclonus are presented, with final diagnoses including idiopathic generalized tremor syndrome and neuronal ceroid lipofuscinosis (NCL)...
April 27, 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29704268/characteristics-of-hemostasis-during-experimental-ehrlichia-canis-infection
#13
Sarah Shropshire, Christine Olver, Michael Lappin
BACKGROUND: Ehrlichia canis infection in dogs can cause thrombocytopenia and clinical evidence of bleeding. It is unknown why some dogs show signs of bleeding whereas others do not despite clinically relevant thrombocytopenia. HYPOTHESIS/OBJECTIVES: Activated platelets, decreased fibrinolysis or both mitigate bleeding tendency. Assess standard hemostatic variables, platelet dynamics, and specialized coagulation testing in dogs experimentally infected with E. canis to evaluate this clinical discrepancy...
April 27, 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29691904/pathological-classification-of-equine-recurrent-laryngeal-neuropathy
#14
REVIEW
Alexandra C E Draper, Richard J Piercy
Recurrent Laryngeal Neuropathy (RLN) is a highly prevalent and predominantly left-sided, degenerative disorder of the recurrent laryngeal nerves (RLn) of tall horses, that causes inspiratory stridor at exercise because of intrinsic laryngeal muscle paresis. The associated laryngeal dysfunction and exercise intolerance in athletic horses commonly leads to surgical intervention, retirement or euthanasia with associated financial and welfare implications. Despite speculation, there is a lack of consensus and conflicting evidence supporting the primary classification of RLN, as either a distal ("dying back") axonopathy or as a primary myelinopathy and as either a (bilateral) mononeuropathy or a polyneuropathy; this uncertainty hinders etiological and pathophysiological research...
April 24, 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29681130/development-and-implementation-of-a-novel-immune-thrombocytopenia-bleeding-score-for-dogs
#15
Kelly M Makielski, Marjory B Brooks, Chong Wang, Jonah N Cullen, Annette M O'Connor, Dana N LeVine
BACKGROUND: A method of quantifying clinical bleeding in dogs with immune thrombocytopenia (ITP) is needed because ITP patients have variable bleeding tendencies that inconsistently correlate with platelet count. A scoring system will facilitate patient comparisons and allow stratification based on bleeding severity in clinical trials. HYPOTHESIS/OBJECTIVES: To develop and evaluate a bleeding assessment tool for dogs, and a training course for improving its consistent implementation...
April 21, 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29681128/association-between-indoor-air-pollution-and-respiratory-disease-in-companion-dogs-and-cats
#16
Chung-Hui Lin, Pei-Ying Lo, Huey-Dong Wu, Chinhao Chang, Lih-Chiann Wang
BACKGROUND: Indoor air pollution (IAP) leads to important respiratory morbidity and mortality in humans. Companion dogs and cats share the same household environment with their owners and are exposed to IAP. HYPOTHESIS: Pets with respiratory disease are more commonly exposed to indoor air pollutants in their homes and to worse air quality than pets without respiratory disease. ANIMALS: Three hundred and forty-eight animals (230 dogs and 118 cats) were recruited...
April 21, 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29671903/a-review-of-mycoplasma-diagnostics-in-cattle
#17
REVIEW
Alysia M Parker, Paul A Sheehy, Mark S Hazelton, Katrina L Bosward, John K House
Mycoplasma species have a global distribution causing serious diseases in cattle worldwide including mastitis, arthritis, pneumonia, otitis media and reproductive disorders. Mycoplasma species are typically highly contagious, are capable of causing severe disease, and are difficult infections to resolve requiring rapid and accurate diagnosis to prevent and control disease outbreaks. This review discusses the development and use of different diagnostic methods to identify Mycoplasma species relevant to cattle, with a particular focus on Mycoplasma bovis...
April 19, 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29671898/serum-levetiracetam-concentrations-and-adverse-events-after-multiple-dose-extended-release-levetiracetam-administration-to-healthy-cats
#18
Heidi Barnes Heller, Martin Granick, Mathew Van Hesteren, Dawn M Boothe
BACKGROUND: Multiple dose administration of antiepileptic drugs to cats presents a challenge for owners. Extended release levetiracetam (XRL) has once daily recommended dosing interval, but multiple dose administration of XRL has not been evaluated in cats. OBJECTIVE: Evaluate serum levetiracetam concentrations and adverse clinical effects after 11 days of once daily XRL administration to healthy cats. ANIMALS: Nine healthy privately owned cats, body weight ≥ 5 kg METHODS: Extended release levetiracetam (500 mg/cat) was administered PO q24h for 10 days...
April 19, 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29663515/determining-optimal-therapy-of-dogs-with-chronic-enteropathy-by-measurement-of-serum-citrulline
#19
Magda Gerou-Ferriani, Rhiannon Allen, Peter-John M Noble, Alexander J German, Marco Caldin, Daniel J Batchelor
BACKGROUND: Serum concentration of citrulline is a useful biomarker in human intestinal disease and indicates globally reduced enterocyte mass and absorptive function in various disease states. OBJECTIVES: To determine whether serum citrulline concentration is a biomarker in chronic enteropathy (CE) in dogs, to provide useful information regarding optimal treatment or to predict outcome. ANIMALS: Seventy-four dogs with CE and 83 breed- and age-matched hospital controls with no clinical signs of intestinal disease...
April 16, 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29660848/international-collaborative-study-to-assess-cardiovascular-risk-and-evaluate-long-term-health-in-cats-with-preclinical-hypertrophic-cardiomyopathy-and-apparently-healthy-cats-the-reveal-study
#20
Philip R Fox, Bruce W Keene, Kenneth Lamb, Karsten A Schober, Valerie Chetboul, Virginia Luis Fuentes, Gerhard Wess, Jessie Rose Payne, Daniel F Hogan, Alison Motsinger-Reif, Jens Häggström, Emilie Trehiou-Sechi, Deborah M Fine-Ferreira, Reid K Nakamura, Pamela M Lee, Manreet K Singh, Wendy A Ware, Jonathan A Abbott, Geoffrey Culshaw, Sabine Riesen, Michele Borgarelli, Michael B Lesser, Nicole Van Israël, Etienne Côté, John E Rush, Barret Bulmer, Roberto A Santilli, Andrea C Vollmar, Maribeth J Bossbaly, Nadine Quick, Claudio Bussadori, Janice M Bright, Amara H Estrada, Dan G Ohad, Maria Josefa Fernández-Del Palacio, Jenifer Lunney Brayley, Denise S Schwartz, Christina M Bové, Sonya G Gordon, Seung Woo Jung, Paola Brambilla, N Sydney Moïse, Christopher D Stauthammer, Rebecca L Stepien, Cecilia Quintavalla, Christophe Amberger, Ferenc Manczur, Yong-Wei Hung, Remo Lobetti, Marie De Swarte, Alice Tamborini, Carmel T Mooney, Mark A Oyama, Andrey Komolov, Yoko Fujii, Romain Pariaut, Masami Uechi, Victoria Yukie Tachika Ohara
BACKGROUND: Hypertrophic cardiomyopathy is the most prevalent heart disorder in cats and principal cause of cardiovascular morbidity and mortality. Yet, the impact of preclinical disease is unresolved. HYPOTHESIS/OBJECTIVES: Observational study to characterize cardiovascular morbidity and survival in cats with preclinical nonobstructive (HCM) and obstructive (HOCM) hypertrophic cardiomyopathy and in apparently healthy cats (AH). ANIMALS: One thousand seven hundred and thirty client-owned cats (430 preclinical HCM; 578 preclinical HOCM; 722 AH)...
April 16, 2018: Journal of Veterinary Internal Medicine
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