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Journal of Veterinary Internal Medicine

Daniela Luethy, Angela E Frimberger, Daniela Bedenice, Barbara S Byrne, Erin S Groover, Rachel B Gardner, Trisha Lewis, Valerie S MacDonald, Lauren Proctor-Brown, Joy E Tomlinson, Kenneth M Rassnick, Amy L Johnson
BACKGROUND: Prognosis associated with lymphoma in horses is poorly characterized, and treatment is often palliative. Long-term outcome after chemotherapy for horses with lymphoma is not well documented. OBJECTIVE: To report long-term outcome of horses with lymphoma treated with chemotherapy. ANIMALS: Fifteen equids. METHODS: Retrospective case series. Medical record search and call for cases on the ACVIM listserv for horses treated with chemotherapy for lymphoma...
January 12, 2019: Journal of Veterinary Internal Medicine
Eva Buresova, Emmelie Stock, Dominique Paepe, Lisa Stammeleer, Eva Vandermeulen, Pascale Smets, Luc Duchateau, Herve P Lefebvre, Sylvie Daminet
BACKGROUND: Measurement of serum creatinine (sCr) and urea nitrogen fail to detect decreased renal function in many hyperthyroid cats because of low muscle mass and glomerular hyperfiltration of affected cats. Serum symmetric dimethylarginine (sSDMA) is an earlier and more sensitive renal biomarker than sCr. OBJECTIVE: Evaluate sSDMA as a biomarker of renal function in hyperthyroid cats before (T0) and 1 month after (T1) radioiodine (131 I) treatment. ANIMALS: Forty-seven client-owned hyperthyroid nonazotemic cats were evaluated at T0 and T1...
January 11, 2019: Journal of Veterinary Internal Medicine
Arlie J Manship, Anthony T Blikslager, Johanna R Elfenbein
BACKGROUND: Equine coronavirus (ECoV) is an emerging pathogen associated with fever and enteric disease in adult horses. Clinical features of ECoV infection have been described, but no study has compared these features to those of Salmonella infections. OBJECTIVES: Compare the clinical features of ECoV infection with enteric salmonellosis and establish a disease signature to increase clinical suspicion of ECoV infection in adult horses. ANIMALS: Forty-three horses >1 year of age with results of CBC, serum biochemistry, and fecal diagnostic testing for ECoV and Salmonella spp...
January 10, 2019: Journal of Veterinary Internal Medicine
Anna Tidholm, Anna Bodegård-Westling, Katja Höglund, Jens Häggström, Ingrid Ljungvall
BACKGROUND: Assessment of left atrial (LA) size is important in medical decision making and prognostication in dogs with myxomatous mitral valve disease (MMVD). Real-time 3-dimensional (RT3DE) and 2-dimensional echocardiographic (2DE) methods may be used to assess LA size. OBJECTIVES: To compare measured LA volumes obtained by RT3DE with those calculated by biplane Simpson's modified method of discs (SMOD) and the area-length method (ALM) using the same RT3DE acquisition with the same timing...
January 9, 2019: Journal of Veterinary Internal Medicine
Giuliana M Gianino, Stephanie J Valberg, Sudeep Perumbakkam, Marisa L Henry, Keri Gardner, Cecilia Penedo, Carrie J Finno
BACKGROUND: Immune-mediated myositis (IMM) in American Quarter Horses (QHs) causes acute muscle atrophy and lymphocytic infiltration of myofibers. Recently, an E321G mutation in a highly conserved region of the myosin heavy chain 1 (MYH1) gene was associated with susceptibility to IMM and nonexertional rhabdomyolysis. OBJECTIVES: To estimate prevalence of the E321G MYH1 variant in the QH breed and performance subgroups. ANIMALS: Three-hundred seven elite performance QHs and 146 random registered QH controls...
January 8, 2019: Journal of Veterinary Internal Medicine
Barbara A Qurollo, Jesse Buch, Ramaswamy Chandrashekar, Melissa J Beall, Edward B Breitschwerdt, Caroline B Yancey, Alexander H Caudill, Alaire Comyn
BACKGROUND: Ehrlichia ewingii is the most seroprevalent Ehrlichia-infecting dogs in the southern and mid-western United States. Fever, lameness, and polyarthritis are commonly reported findings in dogs naturally infected with E. ewingii. OBJECTIVES: To evaluate clinicopathologic findings in a population of dogs naturally infected with E. ewingii. ANIMALS: Forty-one dogs PCR positive for E. ewingii and PCR negative for other targeted vector-borne organisms...
January 2, 2019: Journal of Veterinary Internal Medicine
Francesca Bonelli, Tommaso Vezzosi, Mireille Meylan, Irene Nocera, Vincenzo Ferrulli, Carlotta Buralli, Valentina Meucci, Rosalba Tognetti
BACKGROUND: There is good diagnostic accuracy of smartphone-based ECG in the evaluation of heart rate (HR), heart rhythm, and ECG values for humans, horses, dogs, and cats. OBJECTIVES: Assess feasibility and reliability of a smartphone ECG device to evaluate HR expressed as beats per minute and ECG values in cows. ANIMALS: Fifty-five healthy Holstein Friesian cows. METHODS: Prospective observational study. A standard base-apex ECG was acquired for 60 seconds in each cow...
December 27, 2018: Journal of Veterinary Internal Medicine
Philippa J Johnson, Erica F Barry, Wen-Ming Luh, Emma Davies
INTRODUCTION: The pathogenesis of corpus callosum malformations (CCM) is not well defined in the dog because of inherent limitations of structural magnetic resonance imaging (MRI) to evaluate the white matter. We used the advanced neuroimaging technique of tractography to virtually dissect the white matter projections in a dog with a CCM and in a normal control dog. METHODS: A 9-month-old male Coonhound that had a previous structural MRI diagnosis of CCM and a normal control dog underwent anesthesia and 3-Tesla MRI...
December 26, 2018: Journal of Veterinary Internal Medicine
Quirine E M Stassen, Guy C M Grinwis, Nieke C van Rhijn, Martjin Beukers, Nanda M Verhoeven-Duif, Peter A J Leegwater
BACKGROUND: Focal seizures with fear as a primary ictal manifestation, their diagnostic challenges, and impact on quality of life are well described in human medicine. Reports focusing on ictal fear-like behavior in animals are scarce. OBJECTIVE: To describe the clinical and histopathological characteristics of a novel focal epilepsy in Boerboel dogs. ANIMALS: Five client-owned Boerboel littermates presented for evaluation of sudden episodes of severe fear-related behavior...
December 22, 2018: Journal of Veterinary Internal Medicine
Julie Dauvillier, Fe Ter Woort, Emmanuelle van Erck-Westergren
BACKGROUND: Fungi contribute to the inflammatory response of lungs in horses with recurrent airway obstruction and in some forms of asthma in humans. The role of fungi in inflammatory airway disease (IAD) has not been assessed. OBJECTIVES: Evaluate the prevalence of fungi in the respiratory samples of horses diagnosed with IAD, describe clinical signs associated with the presence of fungi in respiratory samples, and assess the risk factors associated with IAD and with the presence of fungi in the airways...
December 21, 2018: Journal of Veterinary Internal Medicine
Johanna A Forsgård, Liisa Metsähonkala, Anna-Mariam Kiviranta, Sigitas Cizinauskas, Jouni J T Junnila, Outi Laitinen-Vapaavuori, Tarja S Jokinen
BACKGROUND: Stress, sleep deprivation, and infectious diseases are important seizure-precipitating factors in human epilepsy patients. However, these factors have not been thoroughly studied in epileptic dogs. OBJECTIVE: Seizure-precipitating factors are common in dogs with idiopathic epilepsy and the occurrence of these factors associate with the dogs' signalment, personality, and epilepsy-related factors. ANIMALS: Fifty dogs with diagnosed idiopathic epilepsy from the hospital populations of University Veterinary Teaching Hospital of University of Helsinki and Referral Animal Hospital Aisti...
December 21, 2018: Journal of Veterinary Internal Medicine
Maya König, Alice Nentwig, Eliane Marti, Jelena Mirkovitch, Katja-Nicole Adamik, Simone Schuller
BACKGROUND: Angiopoietin-2 (Ang-2) and vascular endothelial growth factor (VEGF) are regulators of endothelial permeability. OBJECTIVE: Plasma concentrations of Ang-2 and VEGF are increased in dogs with systemic inflammatory response syndrome (SIRS) and sepsis and are correlated with disease severity and outcome. ANIMALS: Healthy dogs (n = 18) and client-owned dogs with SIRS (n = 34) or sepsis (n = 25). METHODS: Prospective observational study...
December 21, 2018: Journal of Veterinary Internal Medicine
Peter H Kook, Miriam Baumstark, Maja Ruetten
This report describes the clinical and histologic recovery of a 2-year-old mixed-breed dog presented with hypovolemic shock, markedly increased serum alanine amino transferase activity, and hemoabdomen. Emergency exploratory surgery revealed a friable liver with multiple capsule hemorrhages necessitating removal of the left lateral lobe. Histologic evaluation showed acute massive hepatic necrosis with centrilobular and midzonal distribution. The dog survived, and all monitored laboratory values normalized within 7 weeks...
December 21, 2018: Journal of Veterinary Internal Medicine
Beverly K Sturges, Peter J Dickinson, Linda D Tripp, Irina Udaltsova, Richard A LeCouteur
BACKGROUND: Monitoring of intracranial pressure (ICP) is a critical component in the management of intracranial hypertension. Safety, efficacy, and optimal location of microsensor devices have not been defined in dogs. HYPOTHESIS/OBJECTIVE: Assessment of ICP using a microsensor transducer is feasible in anesthetized and conscious animals and is independent of transducer location. Intraparenchymal transducer placement is associated with more adverse effects. ANIMALS: Seven adult, bred-for-research dogs...
December 21, 2018: Journal of Veterinary Internal Medicine
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No abstract text is available yet for this article.
December 19, 2018: Journal of Veterinary Internal Medicine
Kelsey Goode, Chick Weisse, Allyson Berent, Ken Lamb
BACKGROUND: Mesenteric angiography is a sensitive method for visualizing portal perfusion in the dog. OBJECTIVES: To evaluate hepatic portal perfusion in dogs with incompletely resectable hepatic tumors using mesenteric angiography. ANIMALS: Five client-owned dogs with incompletely resectable hepatic tumors evaluated with mesenteric angiography. METHODS: Retrospective case series. Electronic medical records at the Animal Medical Center were analyzed to identify dogs that underwent mesenteric portography to determine blood flow to nonresectable hepatic tumors and subsequently determine ideal routes for transarterial embolization, vascular stent placement, or both...
December 18, 2018: Journal of Veterinary Internal Medicine
Madeleine J Mattin, David C Brodbelt, David B Church, Adrian Boswood
BACKGROUND: Factors associated with disease progression in dogs with preclinical (stage B) degenerative mitral valve disease (DMVD) have not been evaluated previously in primary care veterinary practice. OBJECTIVES: To evaluate whether plasma cardiac biomarkers, clinical signs, and physical examination findings are associated with clinical progression (reaching the composite endpoint of initiation of treatment with a potent diuretic or cardiac death) in dogs presumed to have stage B DMVD...
December 18, 2018: Journal of Veterinary Internal Medicine
Hajime Asada, Mari Kojima, Takuro Nagahara, Yuko Goto-Koshino, James K Chambers, Taisuke Nakagawa, Nozomu Yokoyama, Kazuyuki Uchida, Hajime Tsujimoto, Koichi Ohno
A 9-month-old intact crossbred female cat was presented with jaundice, intermittent anorexia and lethargy, increased hepatic enzyme activities, and hyperammonemia. Abdominal ultrasound and computed tomographic examinations determined that the liver had a rounded and irregular margin, and histopathological examination identified excessive accumulation of copper hepatocytes in the liver. Concentrations of both blood and urine copper were higher than in healthy cats. The patient responded well to treatment with penicillamine...
December 18, 2018: Journal of Veterinary Internal Medicine
Stacie C Summers, Jessica M Quimby, Anitha Isaiah, Jan S Suchodolski, Paul J Lunghofer, Daniel L Gustafson
BACKGROUND: Intestinal dysbiosis has been documented in humans with chronic kidney disease (CKD) and is thought to contribute to production of the uremic toxins indoxyl sulfate (IS) and p-cresol sulfate (pCS). Characteristics of the fecal microbiome in cats with CKD and correlation to serum concentrations of uremic toxins are unknown. OBJECTIVES: To characterize the fecal microbiome and measure serum IS and pCS concentrations of cats with CKD in comparison to healthy older cats...
December 18, 2018: Journal of Veterinary Internal Medicine
Tony M Glaus, Jonathan Elliott, Esther Herberich, Tanja Zimmering, Balazs Albrecht
BACKGROUND: Efficacy of telmisartan in treating hypertension (HT) in cats has not been largely investigated. OBJECTIVE: Telmisartan oral solution effectively controls systolic arterial blood pressure (SABP) in hypertensive cats. ANIMALS: Two-hundred eighty-five client-owned cats with systemic HT. METHODS: Prospective, multicenter, placebo-controlled, randomized, double-blinded study. Hypertensive cats diagnosed with SABP ≥160 mmHg and ≤200 mmHg without target-organ-damage were randomized (2 : 1 ratio) to receive 2 mg/kg telmisartan or placebo q24 PO...
December 18, 2018: Journal of Veterinary Internal Medicine
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