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Journal of Veterinary Internal Medicine

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https://www.readbyqxmd.com/read/28921665/effects-of-oral-prednisone-administration-on-serum-cystatin-c-in-dogs
#1
J Muñoz, P Soblechero, F J Duque, B Macías-García, P Ruiz, C Zaragoza, R Barrera
BACKGROUND: Oral administration of glucocorticoid alters serum cystatin C (sCysC) concentration in humans. OBJECTIVE: To determine if oral administration of prednisone alters sCysC in dogs without pre-existing renal disease. ANIMALS: Forty six dogs were included: 10 dogs diagnosed with steroid responsive meningitis arteritis (SRMA; group A), 20 dogs diagnosed of pituitary-dependent hyperadrenocorticism (PDH; group B), and 16 healthy control dogs (group C)...
September 18, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28921663/insect-bite-hypersensitivity-in-horses-is-associated-with-airway-hyperreactivity
#2
S Lanz, A Brunner, C Graubner, E Marti, V Gerber
BACKGROUND: Genetic and epidemiologic evidence suggests that in horses, as in other species, different manifestations of hypersensitivity may occur together. HYPOTHESIS: Horses affected with insect bite hypersensitivity (IBH) show airway hyperreactivity (AH) to inhaled histamine, even in the absence of overt clinical signs of equine asthma (EA). ANIMALS: Twenty-two healthy controls (group C), 24 horses suffering from IBH alone (group IBH), and 23 horses suffering from IBH and EA (group IBH/EA)...
September 18, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28913936/detection-of-bovine-coronavirus-in-healthy-and-diarrheic-dairy-calves
#3
D E Gomez, L G Arroyo, Z Poljak, L Viel, J S Weese
BACKGROUND: BCoV is identified in both healthy and diarrheic calves, complicating its assessment as a primary pathogen. OBJECTIVES: To investigate the detection rates of bovine coronavirus (BCoV) in feces of healthy and diarrheic calves and to describe the usefulness of a pancoronavirus reverse transcriptase (RT) PCR (PanCoV-RT-PCR) assay to identify BCoV in samples of diarrheic calves. ANIMALS: Two hundred and eighty-six calves <21 days...
September 15, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28913839/long-term-stability-of-a-compounded-suspension-of-torsemide-5-mg-ml-for-oral-administration
#4
D Adin, P R Johnson, C H Kim, T Nguyenba, S Rosen
BACKGROUND: Torsemide use for congestive heart failure (CHF) has been reported, but prescription frequency is unknown. Commercially available tablet sizes in North America limit dosing precision, indicating a need to evaluate its strength and stability in suspension. OBJECTIVES: To determine the frequency of torsemide prescriptions and to determine a beyond use date (BUD) of a compounded suspension of torsemide for oral administration stored under 2 temperature conditions for 90 days...
September 15, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28895208/thrombocytosis-in-715-dogs-2011-2015
#5
A D Woolcock, A Keenan, C Cheung, J A Christian, G E Moore
BACKGROUND: Thrombocytosis is a hematologic abnormality in dogs that has been associated with various neoplastic, metabolic, and inflammatory conditions. OBJECTIVE: To classify thrombocytosis in dogs based on severity and evaluate whether there are associations between severity and underlying disease processes. ANIMALS: Seven hundred and fifteen dogs with thrombocytosis and 1,430 dogs with normal numbers of platelets. METHODS: Retrospective study...
September 12, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28895200/effects-of-6%C3%A2-weeks-of-parenteral-cobalamin-supplementation-on-clinical-and-biochemical-variables-in-cats-with-gastrointestinal-disease
#6
J Kempf, M Hersberger, R H Melliger, C E Reusch, P H Kook
BACKGROUND: Effects and duration of commonly used protocols for cobalamin (Cbl) supplementation on cellular Cbl deficiency have not been determined in hypocobalaminemic cats. HYPOTHESIS/OBJECTIVES: To evaluate effect of Cbl supplementation on clinical signs, serum and urine methylmalonic acid (MMA) concentrations over 16 weeks. ANIMALS: Twenty client-owned hypocobalaminemic cats with enteropathy. METHODS: Prospective study...
September 12, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28892209/pharmacokinetics-of-mycophenolic-acid-after-intravenous-administration-of-mycophenolate-mofetil-to-healthy-cats
#7
J E Slovak, S M Rivera, J K Hwang, M H Court, N F Villarino
BACKGROUND: Mycophenolate mofetil (MMF), the prodrug of mycophenolic acid (MPA), is becoming increasingly popular as an alternative immunosuppressant in feline medicine. Pharmacokinetic information is not available for cats. OBJECTIVE: The purpose of this study was to determine whether MMF is biotransformed into the active metabolite MPA and to evaluate the disposition of MPA after a 2-hour constant rate intravenous (IV) infusion of MMF in healthy cats. ANIMALS: Healthy cats (n = 6)...
September 11, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28892205/desoxycorticosterone-pivalate-duration-of-action-and-individualized-dosing-intervals-in-dogs-with-primary-hypoadrenocorticism
#8
J A Jaffey, P Nurre, A B Cannon, A E DeClue
BACKGROUND: Clinicians alter dosing for desoxycorticosterone pivalate (DOCP) to mitigate costs, but this practice has not been critically evaluated in a prospective clinical trial. HYPOTHESIS/OBJECTIVES: The duration of action of DOCP is longer than 30 days in dogs with primary hypoadrenocorticism (PH). ANIMALS: A total of 53 client-owned dogs with PH. Twenty-four dogs with newly diagnosed PH (Group 1) and 29 dogs with treated PH (Group 2)...
September 11, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28892202/syringomyelia-and-craniocervical-junction-abnormalities-in-chihuahuas
#9
A-M Kiviranta, C Rusbridge, O Laitinen-Vapaavuori, A Hielm-Björkman, A K Lappalainen, S P Knowler, T S Jokinen
BACKGROUND: Chiari-like malformation (CM) and syringomyelia (SM) are widely reported in Cavalier King Charles Spaniels and Griffon Bruxellois dogs. Increasing evidence indicates that CM and SM also occur in other small and toy breed dogs, such as Chihuahuas. OBJECTIVES: To describe the presence of SM and craniocervical junction (CCJ) abnormalities in Chihuahuas and to evaluate the possible association of CCJ abnormalities with SM. To describe CM/SM-related clinical signs and neurologic deficits and to investigate the association of CM/SM-related clinical signs with signalment, SM, or CCJ abnormalities...
September 11, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28891088/prevalence-of-elevated-serum-creatinine-concentration-in-dogs-presenting-to-a-veterinary-academic-medical-center-2010-2014
#10
J M Babyak, D E Weiner, F Noubary, C R Sharp
BACKGROUND: The epidemiology of kidney disease is not extensively described in dogs. HYPOTHESIS/OBJECTIVES: To better understand the prevalence of elevated serum creatinine concentration in dogs. ANIMALS: Client-owned dogs. METHODS: A retrospective, observational cross-sectional study design was used. We made a dataset of 115,631 hospital visits of all dogs presenting from October 2010 to October 2014. We estimated the prevalence and risk of elevated serum creatinine, defined as >1...
September 11, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28887897/opportunistic-invasive-cutaneous-fungal-infections-associated-with-administration-of-cyclosporine-to-dogs-with-immune-mediated-disease
#11
B B McAtee, K J Cummings, A K Cook, J A Lidbury, J C Heseltine, M D Willard
BACKGROUND: Opportunistic invasive fungal infections (OIFIs) occur in dogs administered immunosuppressive medications. However, the epidemiology of OIFIs among dogs undergoing immunosuppressive treatment is poorly understood. The aims of this study were to (1) estimate the incidence of OIFIs among dogs diagnosed with certain immune-mediated diseases and treated with immunosuppressive drugs, and (2) determine if administration of particular drug(s) was a risk factor for OIFIs. HYPOTHESIS: Dogs receiving cyclosporine treatment (alone or as part of a multidrug protocol) are at higher risk of developing OIFIs...
September 9, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28887894/interobserver-variation-in-the-diagnosis-of-neurologic-abnormalities-in-the-horse
#12
W J A Saville, S M Reed, J P Dubey, D E Granstrom, P S Morley, K W Hinchcliff, C W Kohn, T E Wittum, J D Workman
BACKGROUND: The diagnosis of equine protozoal myeloencephalitis (EPM) relies heavily on the clinical examination. The accurate identification of neurologic signs during a clinical examination is critical to the interpretation of laboratory results. OBJECTIVE: To investigate the level of agreement between board-certified veterinary internists when performing neurologic examinations in horses. ANIMALS: Ninety-seven horses admitted to the Veterinary Teaching Hospital at The Ohio State University from December 1997 to June 1998...
September 9, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28875568/gene-expression-of-matrix-metalloproteinases-and-their-inhibitors-timps-in-meningiomas-of-dogs
#13
M T Mandara, A Reginato, G Foiani, S De Luca, G Guelfi
BACKGROUND: Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) are considered to be key mediators of tumor invasion and metastasis. MMP-2 and MMP-9 are expressed in meningiomas of dogs, but TIMP expression, and variations of specific MMP/TIMP ratios still are unknown in this tumor. HYPOTHESIS/OBJECTIVES: Expression of MMP/TIMP might increase progressively from grade I to grade III meningioma. Therefore, genetic expression of MMP-2 and MMP-9, and specific TIMP-2 and TIMP-1, respectively, has been investigated in meningiomas of different grades...
September 5, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28865107/effect-of-body-position-exercise-and-sedation-on-estimation-of-pulmonary-artery-pressure-in-dogs-with-degenerative-atrioventricular-valve-disease
#14
J D Rhinehart, K E Schober, B A Scansen, V Yildiz, J D Bonagura
BACKGROUND: Severity of pulmonary hypertension (PH) in dogs is related to clinical signs and prognosis. HYPOTHESIS/OBJECTIVES: We hypothesized that Doppler echocardiographic (DE) indices of pulmonary artery pressure (PAP) and pulmonary vascular resistance (PVR) are influenced by independent factors that create clinically important variability of DE-based estimates of PH in dogs. ANIMALS: Thirty-eight client owned dogs with naturally acquired degenerative atrioventricular valve disease and tricuspid regurgitation (TR)...
September 2, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28865106/neonatal-encephalopathy-in-calves-presented-to-a-university-hospital
#15
A W Bianco, G E Moore, S D Taylor
BACKGROUND: While studies have examined bovine dystocia in relation to calf survival, little has been published regarding perinatal morbidity and treatment of newborn calves beyond failure of transfer of passive immunity (FTPI). Neonatal encephalopathy (NE) is a clinical syndrome commonly diagnosed in infants and foals but is poorly described in calves. HYPOTHESIS/OBJECTIVES: To identify risk factors for development of NE in calves and factors predictive of survival...
September 2, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28865097/suspected-phenobarbital-induced-pseudolymphoma-in-a-dog
#16
R Lampe, J Manens, N Sharp
Pseudolymphoma is a drug reaction to anti-epileptics that is well recognized in humans; it has been reported in one cat but not dogs. In this report, lymphoma-like clinical signs are suspected to be secondary to phenobarbital administration in a dog. A 2.5-year-old male, neutered Shepherd mix presented for a 3-day history of progressive ataxia, dazed mentation, pyrexia, and lethargy. While hospitalized, the dog developed generalized lymphadenopathy and sustained pyrexia. The dog was receiving levetiracetam and phenobarbital for epilepsy, and serum concentrations of both were within standard therapeutic ranges...
September 2, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28862354/feline-differential-leukocyte-count-with-procyte-dx-frequency-and-severity-of-a-neutrophil-lymphocyte-error-and-how-to-avoid-it
#17
H W Tvedten, V Andersson, I E Lilliehöök
BACKGROUND: Erroneous neutrophil and lymphocyte counts from analysis of feline blood samples were transferred directly into the hospital information system from the ProCyte Dx hematology instrument in our after-hours laboratory. Errors usually were not detected by the users. HYPOTHESIS/OBJECTIVES: To quantify the frequency and severity of errors associated with the ProCyte Dx analyzer and to identify methods to avoid the errors. ANIMALS: One-hundred six EDTA blood samples routinely submitted from feline hospital patients were analyzed...
September 1, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28862348/immunophenotype-of-peripheral-blood-lymphocytes-in-dogs-with-inflammatory-bowel-disease
#18
A Galler, B C Rütgen, E Haas, A Saalmüller, R A Hirt, W Gerner, I Schwendenwein, B Richter, J G Thalhammer, N Luckschander-Zeller
BACKGROUND: Inflammatory bowel disease (IBD) is common in dogs. Despite the known importance of intestinal lymphocytes in its pathogenesis, little is known about the role of peripheral blood lymphocytes (PBLs) in IBD. OBJECTIVES: The aims of this study were (1) comparison of PBLs analyzed by flow cytometry (FCM) in IBD dogs and healthy controls and (2) comparison of PBLs in IBD dogs at the time of diagnosis and in dogs in clinical remission. ANIMALS: Whole blood samples of 19 IBD dogs at the time of diagnosis and blood samples of 6 dogs in clinical remission were collected...
September 1, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28862347/effects-of-hydroxyethyl-starch-130-0-4-on-serum-creatinine-concentration-and-development-of-acute-kidney-injury-in-nonazotemic-cats
#19
N E Sigrist, N Kälin, A Dreyfus
BACKGROUND: Hydroxyethyl-starch (HES) solutions might have renal adverse effects in humans and dogs. OBJECTIVE: To determine if administration of 6% HES-130/0.4 is associated with an increase in serum creatinine concentration and development of acute kidney injury (AKI) in nonazotemic cats. ANIMALS: A total of 62 critically ill cats; 26 HES exposed and 36 unexposed. METHODS: Retrospective cohort study (2012-2015). Serum creatinine concentrations were recorded and changes in serum creatinine concentrations before exposure (baseline) and 2-10 and 11-90 days, respectively, were determined...
September 1, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28833697/effect-of-intravenously-administered-crystalloid-solutions-on-acid-base-balance-in-domestic-animals
#20
REVIEW
W Muir
Intravenous fluid therapy can alter plasma acid-base balance. The Stewart approach to acid-base balance is uniquely suited to identify and quantify the effects of the cationic and anionic constituents of crystalloid solutions on plasma pH. The plasma strong ion difference (SID) and weak acid concentrations are similar to those of the administered fluid, more so at higher administration rates and with larger volumes. A crystalloid's in vivo effects on plasma pH are described by 3 general rules: SID > [HCO3-] increases plasma pH (alkalosis); SID < [HCO3-] decreases plasma pH (alkalosis); and SID = [HCO3-] yields no change in plasma pH...
September 2017: Journal of Veterinary Internal Medicine
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