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Indian Journal of Clinical Biochemistry: IJCB

Prashant Sakharkar
Many herbal products are harmless or possess minimal toxicity, whereas, some contain toxic ingredients that may not be identified due to lack of quality control or not listed on the label. Over the years, several case reports and studies have documented that herbal medications may contain ingredients that are toxic. Several studies have documented that some herbal medications contained high concentrations of heavy metals, such as lead, mercury, and arsenic. Publications of such case reports and studies have repeatedly reminded us that we have failed in our legal and civic duties of educating users of herbal medications and general population about the grave concerns posed by the herbal medications and their associated toxicities...
October 2017: Indian Journal of Clinical Biochemistry: IJCB
B Vinodh Kumar, M Sivalingam, G Shiva Kumaran, Balambal Balakrishnan
Distal renal tubular acidosis (RTA) manifests either as Complete/Classical form or Incomplete/Latent Form. Distal RTA causes normal anion gap metabolic acidosis and hypokalemia. Interstitial Nephritis is the most frequent renal manifestation of Sjogren's, which presents as Distal RTA in 25-40% of patients with Sjogren's syndrome. Magnesium deficiency is frequently associated with hypokalemia. Although serum calcium is the main physiological control for the secretion of parathyroid hormone (PTH) by the parathyroid, serum magnesium can also exert similar effects...
October 2017: Indian Journal of Clinical Biochemistry: IJCB
Purvi Purohit, Daisy Khera, Praveen Sharma, Kuldeep Singh
Type V hypertriglyceridemia in children is a rare condition since it has often been associated with obesity, type II diabetes, metabolic syndrome and hormone therapy. We encountered a case of massive hypertriglyceridemia (1900 mg/dl) in a 6 years old boy with complains of acute pancreatitis but no physical manifestations. There was no family history of sudden cardiac death, father and younger male sibling were found to be normal. The mother however had hypertriglyceridemia. The child was managed by dietary changes, omega 3 capsules and low dose fenofibrate...
October 2017: Indian Journal of Clinical Biochemistry: IJCB
Ramya Ramani, Abirami Ramachandran, Sriram Ravindran, Gino A Kurian
Sodium thiosulfate (STS), a cyanide antidote has been reported to possess antioxidant and calcium chelation effects, useful for the treatment of renal failure due to vascular calcification and urolithiasis. The present study investigated the in vivo modulatory effects of STS on erythrocyte calcium, phosphorous levels, lipid peroxidation, antioxidant enzyme and membrane ATPase activities (Ca2+, Na+K+, Mg2+ and 5'' nucleotidase) in an adenine induced model of vascular calcification in rats. Adenine (0.75%) was supplemented through the diet for 28 days, which resulted in significantly (P < 0...
October 2017: Indian Journal of Clinical Biochemistry: IJCB
Rinchen D Bhutia, T A Singh, Mingma L Sherpa, Bidita Khandelwal
Sikkim has been reported to have the highest percentage of Diabetes Mellitus and Hypertension in the country. The study aimed to focus its precursor termed 'Metabolic Syndrome' (MetS) with special attention to its risk determinants as a measure to promote awareness in preventing the rise in number of these non communicable diseases in the state with only 6,10,577 inhabitants. Of 361 participants, 33.5% were diagnosed MetS as per the harmonized MetS criteria, 64.5% deemed non-MetS comprised of participants with "2 Risk", "1 Risk" and "0 Risk" for MetS, however not enough (3 or more) to be categorized as MetS...
October 2017: Indian Journal of Clinical Biochemistry: IJCB
Hari Shankar, Neeta Kumar, Rajat Sandhir, Suneeta Mittal, Tulsi Adhikari, Arun Kumar, D N Rao
AIMS: Pregnancy is a phenomenon associated with dynamic changes in physical, mental and biochemical status of body and demands increased nutritional intake for developing foetus. The level of various micronutrients which act as co-factors for antioxidant enzymes or it-self as antioxidants gets altered with the progression of pregnancy. The present longitudinal study summarized the trend of selected micronutrients level in anaemic (AP) and non-anaemic primigravida (NAP) supplemented with daily and weekly oral iron folic acid (IFA) tablet during pregnancy and postpartum...
October 2017: Indian Journal of Clinical Biochemistry: IJCB
R Bhakat, L Chandra, A Saxena, A K Sarda, K Krishnamurthy, P Yadav
Male factor infertility (MFI) is a growing health issue in society. The vitamin D receptor gene (VDR) is expressed in many tissues and modulates expression of several other genes. The purpose of this study was to investigate the association between MetSyn, VDR gene (FokI, rs-2228570; C > T) polymorphisms and MFI in Indian adults. Fifty cases and fifty-four controls, fulfilling inclusion and exclusion criteria, were included with their informed consent. Fasting plasma glucose, triglyceride, HDL-C were estimated by clinical chemistry analyzer (Beckmam Coulter DXC 800, USA)...
October 2017: Indian Journal of Clinical Biochemistry: IJCB
Fereshteh Ahmadipour, Soleiman Mahjoub, Mahdi Pouramir, Abbas Siahposht, Azam Afshar Naderi, Abdorrahim Absalan
Trace element determination is requested rarely for critically ill patients in Iran, due to the underestimation of the trace element determination by Iranian physicians. The aim was to compare the levels of Zn and Mg in a group of hemodialysis patients and normal individuals. This study shows that trace element determination is helpful for management of hemodialysis patients. Fifty-three hemodialysis patients and 51 control individuals were randomly analyzed for Zn and Mg serum levels. Comparison of before or after dialysis and with normal individuals was done and receiver operating characteristics (ROC) curves were plotted to evaluate the analytical sensitivity and specificity of Zn and Mg determination...
October 2017: Indian Journal of Clinical Biochemistry: IJCB
Akshata Mirajkar, Shashikant Nikam, Padmaja Nikam, Giridhar Patil
Human immunodeficiency virus (HIV) infection is a growing concern for health workers. The two major components of dyslipidemia in HIV infected patients are hypertriglyceridemia and decreased levels of high density lipoprotein (HDL) which contribute to increased atherosclerotic risk. The study included 150 newly diagnosed HIV patients and 150 healthy controls. In all these cases Lecithin cholesterol acyl transferase (LCAT) activity was assessed by measuring the difference between esterified and free cholesterol by digitonin precipitation method and levels of Apolipoprotein A-I (apo A-I) were measured by immunoturbidimetric method...
October 2017: Indian Journal of Clinical Biochemistry: IJCB
Nisha Goyal, Bineeta Kashyap, N P Singh, Iqbal R Kaur
Resurgence of TB has emphasized the need for newer methods of diagnosis. Extrapulmonary tuberculosis (EPTB), being paucibacillary, is a diagnostic dilemma. The aim of the present study was to correlate IFN-γ/IL-2 with neopterin in diagnosis of EPTB. Extrapulmonary specimens from 69 clinically diagnosed cases were stained by Ziehl-Neelsen and cultured on Lowenstein-Jensen medium for Mycobacterium tuberculosis. ELISA was used to assess serum IFN-γ, IL-2 and neopterin levels. Median serum levels of IFN-γ/IL-2 and neopterin were 3...
October 2017: Indian Journal of Clinical Biochemistry: IJCB
Khaled M M Koriem, Mahmoud S Arbid, Nawal E Gomaa
The favism is a metabolic disease that characterized with an acute hemolytic anemia where α-tocopherol is a type of tocopherol accumulated inside the human body. The objective of such a study was established to evaluate the effect of α-tocopherol in favism disorders. A total of 75 human cases were divided into 5 groups as follow; group 1 normal cases without any treatment and group 2 normal cases orally administrated α-tocopherol (200 mg/kg) once a day over 30 days period. Group 3 favism patients without any treatment...
October 2017: Indian Journal of Clinical Biochemistry: IJCB
Cleetus Cherupanakkal, Vijayakumar Ramachadrappa, Tamilarasu Kadhiravan, Narayanan Parameswaran, Subhash Chandra Parija, Agieshkumar Balakrishna Pillai, Soundravally Rajendiran
Dengue is an arthropod-borne threat among tropical countries. Currently no effective means to treat the virus or to predict which patient will develop the severe form of the disease. Recently the relationship between oxidative/antioxidative response and dengue pathogenesis was suggested. Based on this the present study has analysed the expression of endogenous antioxidant genes: Catalase (CAT), Superoxide dismutase (MnSOD) and Glutathione peroxidase in patients with dengue compared to other febrile illness (OFI) and healthy controls...
October 2017: Indian Journal of Clinical Biochemistry: IJCB
Pakkiri Bhavani, Perumal Subramanian, Sivamani Kanimozhi
Endometrial carcinoma is a malignant tumor of the female genital tract. This study has been performed to evaluate the chemopreventive efficacy of vanillic acid (a bio flavonoid) on endometrial carcinoma (EC) by assessing the levels of thiobarbituric acid reactive substances (TBARS), lipid hydroperoxides (LOOH), cytochrome P450, antioxidants-superoxide dismutase (SOD), catalase (CAT), glutathione peroxides (GPx), reduced glutathione (GSH), vitamins C and E, matrix metalloproteinases (MMP-2 and 9) and cell cycle check point protein (cyclin D1) in N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) induced carcinogenic rats...
October 2017: Indian Journal of Clinical Biochemistry: IJCB
Sunny O Abarikwu, Aemere Ogunlaja, Chiagoziem A Otuechere, OlatunBosun Gideon
Xylopia aethiopica (Annonaceae) is used in some folk medicines and widely consumed as a spice in some parts of Nigeria. Its efficacy as an anti-androgenic substance has warranted the attention of African scholars. This study evaluated the enzymatic activity of lactate dehydrogenase (LDH), γ-glutamyl transferase (γ-GT), sperm quality (motility, count, morphology), testosterone level and histo-pathological changes of the testis of rats chronically treated with ethanolic extract of the pods (without seeds), seeds, and fruits (pods + seeds) of Xylopia aethiopica...
October 2017: Indian Journal of Clinical Biochemistry: IJCB
Rajat Sandhir, Sandeep Kaur, Saurabh Dhanda
The aim of the present study was to evaluate the effect of N-acetyl-l-cysteine (NAC) on bile duct ligation (BDL) induced oxidative stress in kidneys. Male Wistar rats were randomly segregated into four groups; sham control (SC), SC + NAC, BDL and BDL + NAC group. Liver damage was induced following BDL and renal injury was assessed by kidney function tests along with lipid peroxidation, nitrite levels, thiols and antioxidant enzymes. Three weeks after BDL, rats developed renal dysfunction in terms of elevated serum creatinine levels...
October 2017: Indian Journal of Clinical Biochemistry: IJCB
Upendra Yadav, Pradeep Kumar, Sanjay Gupta, Vandana Rai
Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme of folate pathway. Several polymorphisms were reported in MTHFR gene but C677T polymorphism is most studied and it has been reported to be risk factor for several diseases/disorders. The present study was designed to explore the frequency of MTHFR C677T polymorphism in North Indian healthy population. In addition to this a meta-analysis of published articles was also performed to estimate the global prevalence of MTHFR C677T polymorphism. A total of 1000 unrelated healthy subjects were selected for MTHFR C677T polymorphism analysis...
October 2017: Indian Journal of Clinical Biochemistry: IJCB
Shailendra Dwivedi, Purvi Purohit, Radhieka Misra, Puneet Pareek, Apul Goel, Sanjay Khattri, Kamlesh Kumar Pant, Sanjeev Misra, Praveen Sharma
The current advent of molecular technologies together with a multidisciplinary interplay of several fields led to the development of genomics, which concentrates on the detection of pathogenic events at the genome level. The structural and functional genomics approaches have now pinpointed the technical challenge in the exploration of disease-related genes and the recognition of their structural alterations or elucidation of gene function. Various promising technologies and diagnostic applications of structural genomics are currently preparing a large database of disease-genes, genetic alterations etc...
October 2017: Indian Journal of Clinical Biochemistry: IJCB
Praveen Sharma, Shailendra Dwivedi
No abstract text is available yet for this article.
October 2017: Indian Journal of Clinical Biochemistry: IJCB
Dhiraj J Trivedi, Shrirang P Kulkarni, Rakesh Mudaraddi
Myoglobin is dark red colour heme containing protein, stored in muscle. Change in permeability of myolemma causes myoglobin leak in plasma, which is cleared by kidney swiftly. Differentiating myoglobinuria from hemoglobinuria is important. Clinicians concern over myoglobinuria is to protect the patient from acute renal disease. We present a case of primary myoglobinuria, its clinical symptoms, diagnosis and treatment.
July 2017: Indian Journal of Clinical Biochemistry: IJCB
Dhiraj J Trivedi, Vijayetha P Patil, Pramod S Kamble
Cystinuria is a common aminoaciduria due to a COAL transporter defect in renal tubular epithelium. Increased level of cystine in urine with occasional cystine crystal can be diagnostic. With reference to clinical examinations, symptoms and laboratory reports we present a case of primary cystinuria. Prevention of complication in cystinuric relies on detection at early stage and targeting treatment towards maintaining low level of urinary cystine level.
July 2017: Indian Journal of Clinical Biochemistry: IJCB
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