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Indian Journal of Clinical Biochemistry: IJCB

Arabinda Mohan Bhattarai, Arun Sharma, Sulochana Parajuli, Suju Mool
A 1 year old male child with increased frequency of urine associated with increased thirst was found to have some developmental delays. Laboratory investigations showed increased serum sodium level and serum osmolality with decreased urine osmolality. An empty sella turcica was seen in contrast brain MRI; however focal demyelinating lesion was not present. He was managed with intranasal desmopressin therapy. Developmental delays in such cases can be prevented by early referral to a tertiary health care center where laboratory and imaging facilities are available...
July 2018: Indian Journal of Clinical Biochemistry: IJCB
Xiaorong Wang, Zhifeng Xu, Liyun Xu
The aim of the present study was to investigate the expression of SP100B in mouse models with acute cerebral hemorrhage. Mouse models of cerebral hemorrhage were induced using injection of collagenase into the brain. The serum levels of SP100B were detected by ELISA. The expression of SP100B in the hippocampus and other brain tissue were detected by indirect immunofluorescence technique. The mean concentration of serum SP100B was significantly higher in hemorrhage group (0.85 μg/l) than in control group (0...
July 2018: Indian Journal of Clinical Biochemistry: IJCB
Neelima Singh, Vedika Rathore, Roshan Kumar Mahat, Puneet Rastogi
Cardiac markers are used to evaluate functions of heart. However, there are no satisfactory cardiac biomarkers for the diagnosis of acute myocardial infarction (AMI) within 4 h of onset of chest pain. Among novel cardiac markers, glycogen phosphorylase BB (GPBB) is of particular interest as it is increased in the early hours after AMI. The present study was conducted with the objective to find out the sensitivity and specificity of GPBB over other cardiac markers i.e. myoglobin and CKMB in patients of AMI within 4 h after the onset of chest pain...
July 2018: Indian Journal of Clinical Biochemistry: IJCB
C V Divyambika, S Sathasivasubramanian, G Vani, A J Vanishree, N Malathi
This study aimed to correlate the oxidative stress marker levels in saliva with the clinical stage based on mouth opening, fibrotic bands and histopathological grades of oral submucous fibrosis (OSF) patients. The study included patients clinically diagnosed with OSF (n = 63) and equal number of age and gender matched controls. Patients with OSF were defined by mouth opening stage, fibrotic bands and histopathological grades. Unstimulated saliva from both control and OSF patients were analysed for oxidative markers like lipid peroxides (LPO), non-enzymic antioxidants [reduced glutathione (GSH), vitamin A, vitamin E, vitamin C] and enzymatic antioxidants [glutathione peroxidase (GPx), superoxide dismutase (SOD)] and correlated with different stages and grades...
July 2018: Indian Journal of Clinical Biochemistry: IJCB
Suprava Patel, Rachita Nanda, Sibasish Sahoo, Eli Mohapatra
Proficiency of laboratory services is the mainstay in clinical medicine in providing error free diagnostic results. The efficiency of the laboratory needs to be evaluated as per standard international criterion. The quality indicators of the different phases of total testing process are considered the fundamental measurable tool for evaluation of laboratory performance. In order to optimize the laboratory's proficiency and accreditate it as per international standard in our newly established lab, the study was conducted to evaluate the frequency of errors incurred by laboratory and nonlaboratory professionals during the whole testing process...
July 2018: Indian Journal of Clinical Biochemistry: IJCB
Bineeta Kashyap, Nisha Goyal, N P Singh, Iqbal R Kaur
Pleural tuberculosis accounts for nearly 20% of Extra pulmonary tuberculosis. Adenosine deaminase, commonly used biomarker for the diagnosis, is non specific and there is paucity of literature on its correlation with conventional or newer methods for the diagnosis of extra pulmonary forms of TB. The aim of the study was to assess diagnostic potential of T cell function markers [interferon (IFN-γ), interleukin (IL-2) and IFN-γ/IL-2 ratio]; macrophage activation marker [neopterin]; and oxidative stress markers [protein carbonyl and malondialdehyde (MDA)] in pleural tuberculosis...
July 2018: Indian Journal of Clinical Biochemistry: IJCB
Shaymaa M M Yahya, Gamal A Elmegeed, Mervat S Mohamed, Rafat M Mohareb, Mervat M Abd-Elhalim, Ghada H Elsayed
Hybrid anticancer drugs have emerged as great therapeutic options that can effectively overcome most obstacles facing conventional anticancer drugs. miRNAs are considered as class of non-coding RNAs that can negatively regulate protein coding gene expression. miRNA expression is commonly altered in cancer cells. The current work aimed to test the effect of new pro-apoptotic heterosteroids on some drug resistance related miRNAs expression levels (miRNA34a, 98, and 214) in MCF-7 breast cancer cells. After cell treatment with these compounds 4 , 6 , 7 , 13 , 18 , 21 , 22 and 24 , miRNAs were extracted and subjected to reverse transcription and subsequent PCR amplification using Real Time-PCR technique...
July 2018: Indian Journal of Clinical Biochemistry: IJCB
Priti Chaturvedi, Vinit Mehrotra, Yogesh Saxena, Soumen Manna
Nitric oxide (NO) is one of the key players in the pathogenesis of ischemic stroke. Limited reports are available about the serum level of NO and their correlation with Glasgow Coma Scale (GCS) score in acute (<24 h) ischemic stroke (AIS) patients. A hospital based, cross sectional study was done in North Indian population to find out correlation of serum NO and GCS in AIS patients. 50 patients of AIS and 25 healthy controls were chosen for the study. Serum NO level was measured by ELISA and GCS scores were assessed by a neurologist...
July 2018: Indian Journal of Clinical Biochemistry: IJCB
Shedid Sm, Saada Hn, Eltahawy Na, Hammad As
Radiation induced brain damage is associated with impairment of mitochondrial functions, variations in the level of neurotransmitters, and oxidative stress. Mitochondrial function is closely linked to the level of neurotransmitters since the precursors are supplied by the Kreb's cycle intermediates. The objective of this study was to evaluate the influence of pantothenic acid, an essential component in the synthesis of Coenzyme A (CoA), on the activity of the Krebs cycle enzymes, isocitrate dehydrogenase (IDH), α-ketoglutarate dehydrogenase (α-KGDH), and succinate dehydrogenase (SDH); the level of aspartic, glutamic and GABA; the activity of transaminases, and oxidative stress, in the cerebrum of γ-irradiated rats...
July 2018: Indian Journal of Clinical Biochemistry: IJCB
Tony C Badrick, Anton Gutscher, Daniel Chin
This is the result of a Survey of diagnostics laboratories in the Asia Pacific (APAC) region with perspectives on India, investigating the three key aspects that are central to the success of a laboratory: quality, cost and speed. This Survey provides a comparison in selected performance indicators in a large number of diagnostic laboratories in a broad range of countries in the APAC region. The Survey provides data on some key performance characteristics such as quality improvement activities, staff productivity and Turnaround Time (TAT)...
July 2018: Indian Journal of Clinical Biochemistry: IJCB
Farahnaz Askarian, Amir Ghorbanihaghjo, Hassan Argani, Davoud Sanajou, Nima Nasehi, Roya Askarian, Ravan Ahmadi, Nadereh Rahtchizadeh
Cardiovascular disease, as the leading cause of patient death with chronic kidney disease, could be predicted by carotid atherosclerosis. The aim of the present study was to evaluate a possible relationship between serum soluble tumor necrosis factor-like weak inducer of apoptosis (sTWEAK) and Vitamin D levels with mean right/left carotid intima-media thickness (cIMT), in the hemodialysis (HD) patients. In this cross-sectional study, serums were obtained from 50 stable chronic HD patients and 39 healthy controls...
July 2018: Indian Journal of Clinical Biochemistry: IJCB
N Pavithra, Priyanka S Bannikoppa, Sheila Uthappa, Anura V Kurpad, Indu Mani
Changes in plasma fatty acid (FA) composition and desaturase activities are observed in metabolic syndrome (MS). However, whether these changes are a reflection of dietary intakes of fats and FAs is not well established. The current study was aimed at assessing plasma FA composition and desaturase enzyme activities as biomarkers of dietary intakes in subjects with MS. Case control study was done on 41 MS patients and was compared with age matched 45 controls. Dietary intakes, anthropometric and clinical parameters were measured...
July 2018: Indian Journal of Clinical Biochemistry: IJCB
Namdev S Togre, Priyanka S Bhoj, Vishal K Khatri, Aditya Tarnekar, Kalyan Goswami, Moreshwar R Shende, M V R Reddy
Helminthic infections lead to the release of various molecules which play an important role in modulation of the host immune system. Such filarial proteins with immunomodulatory potential can be used for therapeutic purpose in inflammatory and immune mediated diseases. In the present study, we have explored the prophylactic effect of filarial SXP-RAL family protein of Wuchereria bancrofti i.e. rWbL2 protein in DSS induced inflammatory ulcerative colitis in a mouse model. Prior treatment of rWbL2, followed by induction of colitis, showed significantly reduced disease severity as indicated by the decreased disease manifestations and improved macroscopic and microscopic inflammation...
July 2018: Indian Journal of Clinical Biochemistry: IJCB
Vaishali Kolgiri, Vidya Nagar, Vinayak Patil
HIV-infected adults may be likely to have metabolic syndrome (MS) at younger ages and in the absence of obesity compared with general population. In the present study, we determined prevalence of MS and its association with oxidative deoxy nucleic acid (DNA) damage in HIV-1 infected patients with different ART status. We used plasma level of the oxidized base, 8-hydroxy-2-deoxyguanosine (8-OHdG), as a biomarker of oxidative DNA damage. To measure plasma 8-OHdG we used 8-OHdG enzyme-linked, immunosorbent assay...
July 2018: Indian Journal of Clinical Biochemistry: IJCB
Raju K Mandal, Rama D Mittal
The X-ray repair cross-complementation group 1 ( XRCC1 ) gene plays an important role in base excision repair pathway. Several studies have reported contradictory results for XRCC1 exon 10 (Arg399Gln, G23990A, rs25487) gene polymorphism and cancer risk in Indian population, making it difficult to interpret them. Therefore, we have conducted a meta-analysis to evaluate the more precise association between XRCC1 exon 10 G>A gene polymorphism and risk of cancer by published studies. We searched PubMed (Medline) and Google scholar web databases to cover all studies published on association between XRCC1 exon 10 G>A gene polymorphism and cancer risk until August 2016...
July 2018: Indian Journal of Clinical Biochemistry: IJCB
J A George, R T Erasmus
Diabetes mellitus (DM) has reached epidemic proportions across the globe with the largest increases seen in sub-Saharan Africa. Those that are diagnosed are largely poorly controlled. This review summarizes the limitations of the use of glycated haemoglobin (HBA1c) in Africa and current knowledge on the utility of glycated albumin and fructosamine in African patients. The diagnosis and monitoring of DM in African patients may be compromised by associated conditions like sickle cell anaemia, chronic kidney disease and HIV infection...
July 2018: Indian Journal of Clinical Biochemistry: IJCB
Aman Kumar, Niti Kumari, Vinny Gupta, Rajendra Prasad
Renal cell carcinoma is the most common form of the kidney cancer accounting for more than 85% of the cases of which clear cell renal cell carcinoma (ccRCC) is the major histological subtype. The central molecular signature for ccRCC pathogenesis is the biallelic inactivation of VHL gene due to the presence of mutations/hyper-methylation/complete gene loss, which results in the downstream HIF activation. These events lead to increased tyrosine kinase receptor signalling pathways (RAS/MEK/ERK pathway, PI3K/AKT/mTOR pathway and NF-κB pathway), which through their downstream effector proteins causes the cell to proliferate and migrate...
July 2018: Indian Journal of Clinical Biochemistry: IJCB
Lakshna Mahajan, Shweta Saxena, P Usha Sarma
No abstract text is available yet for this article.
July 2018: Indian Journal of Clinical Biochemistry: IJCB
Manisha Mavai, Yogendra Raj Singh, R C Gupta, Sandeep K Mathur, Bharti Bhandari
[This corrects the article DOI: 10.1007/s12291-017-0659-0.].
April 2018: Indian Journal of Clinical Biochemistry: IJCB
Beuy Joob, Viroj Wiwanitkit
No abstract text is available yet for this article.
April 2018: Indian Journal of Clinical Biochemistry: IJCB
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