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Rheumatic Diseases Clinics of North America

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https://www.readbyqxmd.com/read/29622304/advanced-epidemiologic-methods-for-the-study-of-rheumatic-and-musculoskeletal-diseases
#1
EDITORIAL
Sindhu R Johnson
No abstract text is available yet for this article.
May 2018: Rheumatic Diseases Clinics of North America
https://www.readbyqxmd.com/read/29622303/the-brave-new-world-of-rheumatic-disease-research-today
#2
EDITORIAL
Michael H Weisman
No abstract text is available yet for this article.
May 2018: Rheumatic Diseases Clinics of North America
https://www.readbyqxmd.com/read/29622302/applied-bayesian-methods-in-the-rheumatic-diseases
#3
REVIEW
Sindhu R Johnson, George A Tomlinson, John T Granton, Gillian A Hawker, Brian M Feldman
The use of applied Bayesian methods is increasing in rheumatology. Using the Bayes theorem, past evidence is updated with new data. Preexisting data are expressed as a prior probability distribution or prior. New observations are expressed as a likelihood. Through explicit incorporation of preexisting data and new data, this process informs how this new information should change the way we think. In this article, the authors highlight the use of applied Bayesian methods in the study of rheumatic diseases.
May 2018: Rheumatic Diseases Clinics of North America
https://www.readbyqxmd.com/read/29622301/cluster-and-multiple-correspondence-analyses-in-rheumatology-paths-to-uncovering-relationships-in-a-sea-of-data
#4
REVIEW
Lu Han, Susanne M Benseler, Pascal N Tyrrell
Rheumatic diseases encompass a wide range of conditions caused by inflammation and dysregulation of the immune system resulting in organ damage. Research in these heterogeneous diseases benefits from multivariate methods. The aim of this review was to describe and evaluate current literature in rheumatology regarding cluster analysis and correspondence analysis. A systematic review showed an increase in studies making use of these 2 methods. However, standardization in how these methods are applied and reported is needed...
May 2018: Rheumatic Diseases Clinics of North America
https://www.readbyqxmd.com/read/29622300/measuring-patient-preferences-an-overview-of-methods-with-a-focus-on-discrete-choice-experiments
#5
REVIEW
Glen S Hazlewood
There is increasing recognition of the importance of patient preferences and methodologies to measure them. In this article, methods to quantify patient preferences are reviewed, with a focus on discrete choice experiments. In a discrete choice experiment, patients are asked to choose between 2 or more treatments. The results can be used to quantify the relative importance of treatment outcomes and/or other considerations relevant to medical decision making. Conducting and interpreting a discrete choice experiment requires multiple steps and an understanding of the potential biases that can arise, which we review in this article with examples in rheumatic diseases...
May 2018: Rheumatic Diseases Clinics of North America
https://www.readbyqxmd.com/read/29622299/use-of-administrative-databases-to-assess-reproductive-health-issues-in-rheumatic-diseases
#6
REVIEW
Evelyne Vinet, Eliza F Chakravarty, Julia F Simard, Megan Clowse
Administrative databases, registers, and other sources of big data can be interesting sources to address important research questions on reproduction in women with rheumatic diseases. There are many different types of administrative datasets worldwide, and it is important to understand the type of data present and unavailable in each dataset, validity and potential misclassification of data, and the ability to link maternal data with infant data. This article discusses the advantages and methodologic issues associated with administrative database use for the conduct of observational studies on reproductive issues in women with rheumatic diseases...
May 2018: Rheumatic Diseases Clinics of North America
https://www.readbyqxmd.com/read/29622298/strategies-for-dealing-with-missing-accelerometer-data
#7
REVIEW
Samantha Stephens, Joseph Beyene, Mark S Tremblay, Guy Faulkner, Eleanor Pullnayegum, Brian M Feldman
Missing data is a universal research problem that can affect studies examining the relationship between physical activity measured with accelerometers and health outcomes. Statistical techniques are available to deal with missing data; however, available techniques have not been synthesized. A scoping review was conducted to summarize the advantages and disadvantages of identified methods of dealing with missing data from accelerometers. Missing data poses a threat to the validity and interpretation of trials using physical activity data from accelerometry...
May 2018: Rheumatic Diseases Clinics of North America
https://www.readbyqxmd.com/read/29622297/-big-data-in-rheumatology-intelligent-data-modeling-improves-the-quality-of-imaging-data
#8
REVIEW
Robert B M Landewé, Désirée van der Heijde
Analysis of imaging data in rheumatology is a challenge. Reliability of scores is an issue for several reasons. Signal-to-noise ratio of most imaging techniques is rather unfavorable (too little signal in relation to too much noise). Optimal use of all available data may help to increase credibility of imaging data, but knowledge of complicated statistical methodology and the help of skilled statisticians are required. Clinicians should appreciate the merits of sophisticated data modeling and liaise with statisticians to increase the quality of imaging results, as proper imaging studies in rheumatology imply more than a supersensitive imaging technique alone...
May 2018: Rheumatic Diseases Clinics of North America
https://www.readbyqxmd.com/read/29622296/randomized-trials-meta-analyses-and-systematic-reviews-using-examples-from-rheumatology
#9
REVIEW
Janet E Pope, Glen S Hazlewood
This article introduces contemporary ideas and standards for clinical research in rheumatology for randomized trials, systematic reviews, and meta-analyses. Examples of different randomized trials in rheumatic diseases are provided to understand the methods for trials and the rationale for outcomes within trials. Insights from meta-analyses and systematic literature reviews, including network meta-analyses within rheumatology treatment, are provided. Ethical considerations, sample size calculations, and types of randomized controlled trials are discussed...
May 2018: Rheumatic Diseases Clinics of North America
https://www.readbyqxmd.com/read/29622295/similarity-network-fusion-a-novel-application-to-making-clinical-diagnoses
#10
REVIEW
Andréanne N Zizzo, Lauren Erdman, Brian M Feldman, Anna Goldenberg
Similarity Network Fusion (SNF) is a novel methodological tool that integrates multiple different types of data to identify homogeneous subsets of patients in whom disease classification may be otherwise unclear or challenging. In this review article, the authors hope to provide insight into how SNF can be used in clinical decision making where the aim is to have little influence on the data prior to obtaining the results of the analysis.
May 2018: Rheumatic Diseases Clinics of North America
https://www.readbyqxmd.com/read/29622294/qualitative-methods-to-advance-care-diagnosis-and-therapy-in-rheumatic-diseases
#11
REVIEW
Lesley Ann Saketkoo, John D Pauling
This article provides an overview of the basis, usefulness, and validity of qualitative methods in research. It is aimed to enhance the understanding of a broad spectrum of readers, ranging from those mystified by such approaches, to those wanting a better critical knowledge to apply to literature review, and for health care providers considering developing an interest in the field. Qualitative research is crucial in augmentation of disease knowledge as well as the development of incremental care strategies and operational aspects of care that improves health outcomes...
May 2018: Rheumatic Diseases Clinics of North America
https://www.readbyqxmd.com/read/29622293/us-national-health-and-nutrition-examination-survey-arthritis-initiatives-methodologies-and-data
#12
REVIEW
Charles F Dillon, Michael H Weisman
The US National Health and Nutrition Examination Survey (NHANES) has collected population-based, nationally representative examination, laboratory, and radiographic data for arthritis and musculoskeletal diseases for more than 50 years. The resulting body of data and publications are substantial, yet much data remain unpublished. This review provides a basic understanding of the design and capabilities of the NHANES survey, reviewing the major accomplishments in the area of arthritis and musculoskeletal diseases...
May 2018: Rheumatic Diseases Clinics of North America
https://www.readbyqxmd.com/read/29622292/propensity-score-methods-for-bias-reduction-in-observational-studies-of-treatment-effect
#13
REVIEW
Sindhu R Johnson, George A Tomlinson, Gillian A Hawker, John T Granton, Brian M Feldman
A challenge to the use of observational data to study treatment effects is the issue of confounding. Noncomparability of exposed and nonexposed subjects can lead to biased estimation of the treatment effect. The propensity score is a balancing score that can be used to form matched groups, or pairs, that are not systematically different and enable nonbiased comparisons between groups. This article reviews propensity score methods with an illustrative example of the application of propensity score matching in an observational study of an uncommon disease (systemic sclerosis)...
May 2018: Rheumatic Diseases Clinics of North America
https://www.readbyqxmd.com/read/29622291/alternative-design-and-analytical-techniques-for-longitudinal-rheumatology-studies-improved-understanding-of-outcomes
#14
REVIEW
Lily Siok Hoon Lim, Brian M Feldman, Lisa M Lix
Longitudinal cohort designs (with three or more measurement occasions) are invaluable to investigate between- and within-individual variation in outcomes. However, traditional longitudinal designs require a lengthy implementation and data collection period and impose a substantial burden on participants and investigators. We discuss alternative longitudinal designs, including planned missing data designs and retrospective cohort studies with secondary data, which require a shorter period for data accrual and reduce participant burden while maintaining statistical power...
May 2018: Rheumatic Diseases Clinics of North America
https://www.readbyqxmd.com/read/29622290/minimal-clinically-important-difference-a-review-of-outcome-measure-score-interpretation
#15
REVIEW
Lisa Engel, Dorcas E Beaton, Zahi Touma
Clinicians, researchers, and outcome stakeholders have the crucial, albeit difficult, task of quantifying when a person or group experiences important change or difference on any given outcome measure, often in response to a specific intervention. The minimal clinically important difference (MCID) provides this quantified value of change/difference for a measure. There are many methods for MCID derivation, which can result in multiple values for the same measure. Thus, it is important for potential users of MCID values to be aware of the nuances of MCID development and cautions for interpreting values...
May 2018: Rheumatic Diseases Clinics of North America
https://www.readbyqxmd.com/read/29149931/the-intersection-of-autoimmunity-arthritis-and-the-alimentary-canal
#16
EDITORIAL
Liron Caplan
No abstract text is available yet for this article.
February 2018: Rheumatic Diseases Clinics of North America
https://www.readbyqxmd.com/read/29149930/digestive-and-hepatic-aspects-of-the-rheumatic-diseases
#17
EDITORIAL
Michael H Weisman
No abstract text is available yet for this article.
February 2018: Rheumatic Diseases Clinics of North America
https://www.readbyqxmd.com/read/29149929/gastrointestinal-and-hepatic-disease-in-rheumatoid-arthritis
#18
REVIEW
Ethan Craig, Laura C Cappelli
Gastrointestinal (GI) manifestations of rheumatoid arthritis (RA) are rare, but can be impactful for patients. Some GI processes are directly related to RA, whereas others may be sequelae of treatment or caused by concomitant autoimmune diseases. This article discusses the role of the GI tract in RA pathogenesis; the presentation, epidemiology, and diagnosis of RA-related GI manifestations; concomitant GI autoimmune diseases that may affect those with RA; and GI side effects of RA treatment. The importance of appropriately considering conditions unrelated to RA in the differential diagnosis when evaluating new GI symptoms in patients with RA is noted...
February 2018: Rheumatic Diseases Clinics of North America
https://www.readbyqxmd.com/read/29149928/rheumatic-manifestations-in-autoimmune-liver-disease
#19
REVIEW
Carlo Selmi, Elena Generali, Merrill Eric Gershwin
Autoimmune liver diseases coexist with rheumatic disorders in approximately 30% of cases and may also share pathogenic mechanisms. Autoimmune liver diseases result from an immune-mediated injury of different tissues, with autoimmune hepatitis (AIH) targeting hepatocytes, and primary biliary cholangitis (PBC) and primary sclerosing cholangitis targeting cholangiocytes. Sjogren syndrome is diagnosed in 7% of AIH cases and serologic autoimmunity profiles are a common laboratory abnormality, particularly in the case of serum antimitochondrial (PBC) or anti-liver kidney microsomal antibodies (AIH)...
February 2018: Rheumatic Diseases Clinics of North America
https://www.readbyqxmd.com/read/29149927/gastrointestinal-involvement-in-beh%C3%A3-et-disease
#20
REVIEW
Ibrahim Hatemi, Gulen Hatemi, Aykut Ferhat Çelik
Behçet disease (BD) is a variable vessel vasculitis that can involve several organs and systems. Gastrointestinal (GI) involvement has an acute exacerbating course with ulcers, most commonly in the ileocolonic area. These ulcers can be large and deep, causing perforation and massive bleeding. This article highlights the current knowledge on the epidemiology, clinical findings, diagnosis, and management of GI involvement of BD, with emphasis on recent findings.
February 2018: Rheumatic Diseases Clinics of North America
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