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Rheumatic Diseases Clinics of North America

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https://www.readbyqxmd.com/read/29149931/the-intersection-of-autoimmunity-arthritis-and-the-alimentary-canal
#1
EDITORIAL
Liron Caplan
No abstract text is available yet for this article.
February 2018: Rheumatic Diseases Clinics of North America
https://www.readbyqxmd.com/read/29149930/digestive-and-hepatic-aspects-of-the-rheumatic-diseases
#2
EDITORIAL
Michael H Weisman
No abstract text is available yet for this article.
February 2018: Rheumatic Diseases Clinics of North America
https://www.readbyqxmd.com/read/29149929/gastrointestinal-and-hepatic-disease-in-rheumatoid-arthritis
#3
REVIEW
Ethan Craig, Laura C Cappelli
Gastrointestinal (GI) manifestations of rheumatoid arthritis (RA) are rare, but can be impactful for patients. Some GI processes are directly related to RA, whereas others may be sequelae of treatment or caused by concomitant autoimmune diseases. This article discusses the role of the GI tract in RA pathogenesis; the presentation, epidemiology, and diagnosis of RA-related GI manifestations; concomitant GI autoimmune diseases that may affect those with RA; and GI side effects of RA treatment. The importance of appropriately considering conditions unrelated to RA in the differential diagnosis when evaluating new GI symptoms in patients with RA is noted...
February 2018: Rheumatic Diseases Clinics of North America
https://www.readbyqxmd.com/read/29149928/rheumatic-manifestations-in-autoimmune-liver-disease
#4
REVIEW
Carlo Selmi, Elena Generali, Merrill Eric Gershwin
Autoimmune liver diseases coexist with rheumatic disorders in approximately 30% of cases and may also share pathogenic mechanisms. Autoimmune liver diseases result from an immune-mediated injury of different tissues, with autoimmune hepatitis (AIH) targeting hepatocytes, and primary biliary cholangitis (PBC) and primary sclerosing cholangitis targeting cholangiocytes. Sjogren syndrome is diagnosed in 7% of AIH cases and serologic autoimmunity profiles are a common laboratory abnormality, particularly in the case of serum antimitochondrial (PBC) or anti-liver kidney microsomal antibodies (AIH)...
February 2018: Rheumatic Diseases Clinics of North America
https://www.readbyqxmd.com/read/29149927/gastrointestinal-involvement-in-beh%C3%A3-et-disease
#5
REVIEW
Ibrahim Hatemi, Gulen Hatemi, Aykut Ferhat Çelik
Behçet disease (BD) is a variable vessel vasculitis that can involve several organs and systems. Gastrointestinal (GI) involvement has an acute exacerbating course with ulcers, most commonly in the ileocolonic area. These ulcers can be large and deep, causing perforation and massive bleeding. This article highlights the current knowledge on the epidemiology, clinical findings, diagnosis, and management of GI involvement of BD, with emphasis on recent findings.
February 2018: Rheumatic Diseases Clinics of North America
https://www.readbyqxmd.com/read/29149926/drug-induced-gastrointestinal-and-hepatic-disease-associated-with-biologics-and-nonbiologic-disease-modifying-antirheumatic-drugs
#6
REVIEW
Patrick R Wood, Liron Caplan
A variety of gastrointestinal adverse drug reactions are seen in nearly all conventional antirheumatic medications, ranging from nausea to life-threatening drug-induced liver injury. Rheumatologists should be particularly familiar with hepatotoxicity associated with long-term methotrexate use, and the range of unique hepatic, biliary, and pancreatic manifestations associated with azathioprine. Hepatitis B virus reactivation is the most serious gastrointestinal disease risk associated with many biological therapies, particularly rituximab...
February 2018: Rheumatic Diseases Clinics of North America
https://www.readbyqxmd.com/read/29149925/gastrointestinal-and-hepatic-disease-in-systemic-lupus-erythematosus
#7
REVIEW
Brian N Brewer, Diane L Kamen
Gastrointestinal (GI) symptoms are common among patients with systemic lupus erythematosus (SLE), although only rarely are they caused by active organ system involvement from SLE itself. Rapid diagnosis and appropriate treatment of lupus enteritis and other GI manifestations of SLE are critical, because of the potential for organ and life-threatening complications. The 3 main variants of lupus enteritis are lupus mesenteric vasculitis, intestinal pseudo-obstruction, and protein-losing enteropathy. These GI manifestations and others in patients with SLE are reviewed here...
February 2018: Rheumatic Diseases Clinics of North America
https://www.readbyqxmd.com/read/29149924/gastrointestinal-and-hepatic-disease-in-spondyloarthritis
#8
REVIEW
Liron Caplan, Kristine A Kuhn
The association of inflammatory arthritis with intestinal pathology extends back more than 100 years. This association is now supported by epidemiologic studies demonstrating an elevated prevalence of inflammatory bowel disease in spondyloarthritis and vice versa, compared with the general population. Genetic and intestinal microbiome studies have further linked these diseases. Although diabetes and nonalcoholic fatty liver disease disproportionately affect individuals with psoriatic arthritis, diseases of the esophagus, stomach, pancreas, and liver are not particularly common in spondyloarthritis...
February 2018: Rheumatic Diseases Clinics of North America
https://www.readbyqxmd.com/read/29149923/gastrointestinal-and-hepatic-disease-in-systemic-sclerosis
#9
REVIEW
Tracy M Frech, Diane Mar
Although classification criteria for systemic sclerosis (SSc) do not incorporate gastrointestinal tract (GIT) manifestations often present in this disease, the GIT is the most common internal organ involved. Pathophysiology of GIT involvement is thought to be similar to other organs in SSc with fibroproliferative vascular lesions of small arteries and arterioles, increased production of profibrotic growth factors, and alterations of innate, humoral, and cellular immunity. These processes result in neuropathy progressing to myopathy with eventual fibrosis...
February 2018: Rheumatic Diseases Clinics of North America
https://www.readbyqxmd.com/read/29149922/gastrointestinal-and-hepatic-disease-in-sjogren-syndrome
#10
REVIEW
Yevgeniy Popov, Karen Salomon-Escoto
Sjogren syndrome (SS) is a lymphocyte-mediated, infiltrative autoimmune disorder characterized by destruction of exocrine glands leading to secretory dysfunction. The typical manifestations include xerostomia and xerophthalmia; however, extensive gastrointestinal involvement is increasingly being recognized, emphasizing the variable and systemic nature of SS.
February 2018: Rheumatic Diseases Clinics of North America
https://www.readbyqxmd.com/read/29149921/gastrointestinal-and-hepatic-disease-in-fibromyalgia
#11
REVIEW
Richard A Schatz, Baharak Moshiree
Fibromyalgia (FM) has historically been associated with several diseases in gastroenterology and hepatology. The most substantiated evidence pertains to irritable bowel syndrome (IBS). The pathogeneses of FM and IBS remain unclear, but it is likely related to dysregulation within the brain-gut axis, resulting in a hyperalgesic state. IBS and FM share other similarities, including a female predominance, fatigue, insomnia, and susceptibility to psychiatric state. These common manifestations and pathogeneses serve as a foundation for overlapping, multidisciplinary treatment modalities...
February 2018: Rheumatic Diseases Clinics of North America
https://www.readbyqxmd.com/read/29149920/gastrointestinal-and-hepatic-disease-in-the-inflammatory-myopathies
#12
REVIEW
Chiranjeevi Gadiparthi, Amneet Hans, Kyle Potts, Mohammad K Ismail
Although muscle weakness is the pathognomonic feature of idiopathic inflammatory myopathies, systemic organ involvement is not uncommon. The gastrointestinal and hepatic manifestations are well known. Oropharyngeal dysphagia is the most common gastrointestinal symptom and can be severe. Gastric and small intestinal motility disorders, including chronic intestinal pseudo-obstruction, celiac disease, and inflammatory bowel disease have been described. Comprehensive cancer screening is warranted soon after the diagnosis of inflammatory myopathies due to high risk of occult malignancies...
February 2018: Rheumatic Diseases Clinics of North America
https://www.readbyqxmd.com/read/29149919/gastrointestinal-and-hepatic-disease-in-vasculitis
#13
REVIEW
Eric Anderson, Neel Gakhar, Courtney Stull, Liron Caplan
Vasculitis is an inflammatory condition that targets the blood vessels, which may occur in isolation or as a component of a systemic inflammatory condition. Although many of the vasculitides can directly affect the organs of the gastrointestinal system, some types exhibit a proclivity for certain gastrointestinal and hepatic organs. Often a patient presents with nonspecific symptoms, delaying the diagnosis and treatment of the underlying vasculitis. Vasculitis can also present with severe manifestations, such as upper gastrointestinal bleeds and bowel perforation...
February 2018: Rheumatic Diseases Clinics of North America
https://www.readbyqxmd.com/read/29061250/neurologic-manifestations-of-rheumatic-diseases
#14
EDITORIAL
Sarah E Goglin, John B Imboden
No abstract text is available yet for this article.
November 2017: Rheumatic Diseases Clinics of North America
https://www.readbyqxmd.com/read/29061249/neurologic-manifestations-of-rheumatic-diseases
#15
EDITORIAL
Michael H Weisman
No abstract text is available yet for this article.
November 2017: Rheumatic Diseases Clinics of North America
https://www.readbyqxmd.com/read/29061248/involvement-of-the-peripheral-nervous-system-in-polyarteritis-nodosa-and-antineutrophil-cytoplasmic-antibodies-associated-vasculitis
#16
REVIEW
John B Imboden
Peripheral nerve involvement is common in polyarteritis nodosa and the antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitides. The underlying mechanism is arteritis of the vasa nervorum, leading to ischemic neuropathy. The classic presentation is stepwise involvement of peripheral nerves with ongoing antecedent constitutional symptoms. This article reviews the pathologic findings, clinical syndromes, diagnosis, and treatment of ANCA-associated vasculitides.
November 2017: Rheumatic Diseases Clinics of North America
https://www.readbyqxmd.com/read/29061247/neurologic-features-of-immunoglobulin-g4-related-disease
#17
REVIEW
Mahmoud AbdelRazek, John H Stone
Immunoglobulin G4-related disease (IgG4-RD) can involve nearly any organ system, including the central and peripheral nervous systems. IgG4 antibodies are not known to play a primary etiologic role in disease. IgG4-RD must be distinguished from a growing number of immune-mediated conditions in which IgG4 autoantibodies contribute directly to pathophysiology. The most common neurologic features of IgG4-RD result from disease in the orbits, pachymeninges, and substance of the pituitary gland and stalk, as well as a perineuropathy that can involve peripheral or cranial nerves...
November 2017: Rheumatic Diseases Clinics of North America
https://www.readbyqxmd.com/read/29061246/central-nervous-system-infections-associated-with-immunosuppressive-therapy-for-rheumatic-disease
#18
REVIEW
Michael J Bradshaw, Tracey A Cho, Felicia C Chow
Patients on immunosuppressive therapy for rheumatic diseases are at increased risk of infection. Although infections of the central nervous system (CNS) are less common compared with other sites, patients on broadly immunosuppressive and biologic immunomodulatory agents may be susceptible to more severe, disseminated forms of infection, including of the CNS. Certain key principles regarding infection risk apply across immunosuppressive therapies, including increased risk with higher doses and longer duration of therapy and with combination therapy...
November 2017: Rheumatic Diseases Clinics of North America
https://www.readbyqxmd.com/read/29061245/neurosarcoidosis
#19
REVIEW
Patompong Ungprasert, Eric L Matteson
Neurosarcoidosis occurs in 3% to 10% of patients with sarcoidosis. Cranial neuropathy and meningeal involvement are the most common manifestations, but any part of the nervous system can be affected. Definite diagnosis requires the presence of noncaseating granuloma in the nervous system, although histopathologic confirmation is often not obtainable. Moderate to high dose of glucocorticoids is the main therapy for neurosarcoidosis. Relapse often occurs after the dose of glucocorticoids is tapered down, often necessitating the use of steroid-sparing immunosuppressive agents...
November 2017: Rheumatic Diseases Clinics of North America
https://www.readbyqxmd.com/read/29061244/neuromyelitis-optica
#20
REVIEW
Sarah L Patterson, Sarah E Goglin
Neuromyelitis optica (NMO), formerly known as Devic disease, is an autoimmune astrocytopathic disease characterized by transverse myelitis and optic neuritis. Most patients demonstrate a relapsing course with incomplete recovery between attacks, resulting in progressive disability. The pathogenesis involves production of aquaporin-4 antibodies (AQP4-IgG) by plasmablasts in peripheral circulation, disruption of the blood-brain barrier, complement-mediated astrocyte injury, and secondary demyelination. The diagnosis relies on characteristic clinical manifestations in the presence of serum AQP4-IgG positivity or specific neuroimaging findings, and exclusion of alternative etiologies...
November 2017: Rheumatic Diseases Clinics of North America
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