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Functional Neurology

S Liguori, A de Sire, A Moretti, L Sodano, S Sampaolo, Francesca Gimigliano, Giovanni Iolascon
No abstract text is available yet for this article.
April 2018: Functional Neurology
Alessio Baricich, L Cosenza, Giorgio Sandrini, Stefano Paolucci, G Morone, A Santamato, N Cinone, E Peri, A Picelli, M Invernizzi, G Ferriero
In the emerging scenario of patient-centered medicine, it is becoming increasingly important to involve patients in the management of chronic diseases. The rehabilitation field currently has no assessment tool for evaluating the functional impact of post-stroke spasticity on activities of daily living. The aim of this study was to identify a tool to fill this gap. The "Spasticity Questionnaire in Real Life" (SPQR) was administered, twice, to 39 patients with poststroke spasticity. Statistical analysis showed internal consistency and reliability of the questionnaire, with values greater than 0...
April 2018: Functional Neurology
M R Lo Monaco, A Laudisio, D Fusco, D L Vetrano, D Ricciardi, V Delle Donne, F Proietti, Giuseppe Zuccalà, Maria Caterina Silveri
Experimental evidence suggests that motor imagery (MI) engages the same neural substrates supporting actual motor activities and is likely impaired when such substrates are damaged, as in Parkinson's disease (PD). MI intuitively relies on visual imagery (VI), because mental simulations of physical movements depend on the visual retrieval of these movements. Although VI is generally considered a right hemispheric function, the hemispheric dominance of MI is still in dispute. Disparities in sidedness of motor disturbances are a distinctive feature of PD, and recent findings indicate that such disparities may similarly characterize cognition...
April 2018: Functional Neurology
R Avesani, F Dambruoso, M Scandola, Rita Formisano, Antonio De Tanti, S Ferro, Nicola Smania, L Roncari, E Rossato
Recent studies on recovery of consciousness of subjects in a vegetative state (VS) admitted to rehabilitation units have focused mainly on the identification of prognostic factors, whereas few studies have focused on outcome. The aim of this study was to compare demographic and clinical data and report functional outcome of patients in a VS due to severe acquired brain injury (ABI) of different aetiologies. The study was a retrospective multicentre cohort study and involved 492 patients in a VS due to traumatic (TBI) or non-traumatic (NTBI) severe ABI admitted to 29 Italian rehabilitation units...
April 2018: Functional Neurology
D Saviola, Antonio De Tanti, S Delsoldato, M Chiari, M G Inzaghi, F Baldari
Safe resumption of driving after a severe acquired brain injury (sABI) is a strongly felt need because driving is related to recovery of independence and social-occupational re-integration. The aim of this prospective observational cohort study was to determine whether epilepsy secondary to sABI is a significant factor for being declared fit to drive by the relevant government authorities in Italy. In the period 2006-2015 we recruited 187 patients with sABI, 30 of whom (16.4%) developed secondary epilepsy. The interval between the acute event and the first seizure varied widely (6-96 months), confirming the need for prolonged follow-up...
April 2018: Functional Neurology
Koichi Hiraoka, Yuki Kento, Hiroki Kiya, Yui Nozaki, Tatsuya Hayashi
This study looked for a direction-specific cortical response immediately after application of moving tactile stimuli in healthy female humans. Four pairs of stimulus electrodes were placed over the left index finger pulp on the distal-proximal axis. Four times, once in every 40 ms interval, an electrical stimulus to the finger pulp was delivered through one of the four pairs of electrodes; each time the stimulus site changed in order to induce a sensation of tactile motion. The slope of the electroencephalographic trace, as recorded from electrodes placed over the CP, P4 and right hMT+/V5 in the period 150-200 ms after the onset of stimuli delivered in sequence from the distal to proximal site, was significantly different from that after stimuli delivered in sequence from the proximal to distal site...
April 2018: Functional Neurology
A Zafar
Published studies have shown differences in types and underlying mechanisms of stroke between different regions of the world. There is a lack of published literature describing the characteristics of acute stroke in Saudi Arabia. The aim of this study was to identify different types and associated risk factors among acute stroke patients in Saudi Arabia. In this descriptive study, records of 500 patients with acute stroke were included. Acute stroke was classified as ischemic stroke, intracerebral hemorrhage, cerebral venous sinus thrombosis or subarachnoid hemorrhage...
April 2018: Functional Neurology
S A Gómez Ochoa, B B Espín Chico
Hyperglycemia-associated chorea-ballism (HCB) is an infrequent neurological syndrome whose pathophysiology remains poorly understood. Positron emission tomography (PET) studies have offered valuable information regarding regional glucose metabolism. The studies included were published between 1980-2017 and reported demographic, clinical, laboratory and imaging data from patients with HCB in whom a PET scan had been performed. Eleven patients were evaluated (women 82%, Asian origin 91%, mean age 71 years). The main findings were an increase in glucose metabolism at the contralateral motor cortex related to recent episodes of hemiballism-hemichorea in 2 patients, and an altered metabolism in the affected basal ganglia in all of them: decreased in 10 patients (91%) and increased in 1 (9%)...
April 2018: Functional Neurology
Rita Formisano, Marianna Contrada, Marta Aloisi
No abstract text is available yet for this article.
April 2018: Functional Neurology
Paolo Rossi, P Little, E R De La Torre, A Palmaro
Cluster headache (CH) is arguably the most severe pain condition that afflicts humans. The severity of the pain has earned it the nickname "suicide headache". Understanding how CH impacts on those who suffer from it is essential, because this understanding creates empathy, which is so valuable to these patients. On the occasion of Cluster Headache Day 2017, we asked CH patients from different European countries to share their experiences, in order to help people to imagine what it means to live with the condition...
January 2018: Functional Neurology
Vincenzo Raieli, E Correnti, A Sandullo, M Romano, F Marchese, C Loiacono, Filippo Brighina
It is crucial that all headache specialists receive adequate training. Considering the unsatisfactory results obtained with standard updating courses and the growing need for continuing professional education, a digital platform was developed as a training tool. The platform has been active since 1 October 2014. It is readily accessible to doctors by free registration. Users have access to all the material available on the platform, which includes scientific articles, e-books, presentations and images. Users can share their own material and clinical cases directly...
January 2018: Functional Neurology
F Bove, G Di Lazzaro, D Mulas, F Cocciolillo, D Di Giuda, A R Bentivoglio
Accelerometry is a reliable tool for gauging the occurrence, amplitude and frequency of tremor. However, there is no consensus on criteria for accelerometric diagnosis of tremor syndromes. We enrolled 20 patients with essential tremor (ET), 20 with dystonic tremor (DT), and 20 with classic parkinsonian tremor (PD-T), all meeting accepted clinical criteria. All the patients underwent dopamine transporter imaging (by means of single-photon emission computed tomography) and triaxial accelerometric tremor analysis...
January 2018: Functional Neurology
Giorgio Sandrini, A Baricich, C Cisari, Stefano Paolucci, Nicola Smania, A Picelli
The present paper provides practical guidance on the management of adult spasticity with OnabotulinumtoxinA. Advisory Board members reviewed the available evidence and discussed their personal experiences in order to address the unmet needs in the management of spasticity with botulinum toxin type A identified by the recent Italian Real-Life Post-Stroke Spasticity Survey. Stroke patients should be referred to spasticity services that have adequate facilities and multidisciplinary teams with the necessary training, competence and expertise...
January 2018: Functional Neurology
V Valentino, Alessandro Iavarone, M Amboni, F Moschiano, M Picillo, V Petretta, G Cicarelli
Apathy is a state of diminished goal-directed speech, motor activity and emotions. The prevalence of apathy in Parkinson's disease (PD) ranges from 16 to 62%. Several studies have investigated the relationships between apathy and other dimensions of PD, but little is known about possible discrepancies between self-evaluation (SE) and caregiver reporting (CR) of this symptom. The aim of this study is twofold: 1) to investigate the differences in apathy evaluations according to the point of view from which apathy is reported (SE vs CR); 2) to identify the possible relationships between each of the two evaluations (SE and CR) and cognitive and affective dimensions of PD...
January 2018: Functional Neurology
A Pascarella, S Fiorenza, O Masotta, V Tibollo, D Vella, Anna Maria Nardone, Marta Rossi, P Volanti, F Madonia, Gaetano Cstronovo, D De Cicco, Caterina Guarnaschelli, M P Achilli, C Chiapparino, M T Angelillo, M A Tommasi, F Pisano, G Grioni, G Vezzadini, G Ferriero, S Salvaderi, R Bellazzi, Anna Estraneo
Diagnostic accuracy and reliable estimation of clinical evolution are challenging issues in the management of patients with disorders of consciousness (DoC). Longitudinal systematic investigations conducted in large cohorts of patients with DoC could make it possible to identify reliable diagnostic and prognostic markers. On the basis of this consideration, we devised a multicentre prospective registry for patients with DoC admitted to ten intensive rehabilitation units. The registry collects homogeneous and detailed data on patients' demographic and clinical features, neurophysiological and neuroimaging findings, and medical and surgical complications...
January 2018: Functional Neurology
A Ferrari, M Manca, V Tugnoli, L Alberto
Three different type A botulinum neurotoxins (BoNTAs) - onabotulinumtoxinA, abobotulinumtoxinA and incobotulinumtoxinA) - are currently marketed in Europe to treat several conditions. Differences between BoNTA preparations, which depend on their specific biotypes and manufacturing processes, lead to clinically relevant pharmacotherapeutic dissimilarities. All three available products are separately recognized and reviewed in American Academy of Neurology guidelines. The neurotoxin load/100U is likewise different among the different BoNTAs, with the result that the specific potency of the 150kD BoNTA neurotoxin is calculated as 137 units/ng for onabotulinumtoxinA, 154 units/ng for abobotulinumtoxinA, and 227 units/ng for incobotulinumtoxinA...
January 2018: Functional Neurology
C Zivelonghi, S Tamburin
No abstract text is available yet for this article.
January 2018: Functional Neurology
S Juhl, G Rubboli
This study aimed to investigate the incidence of aggressiveness in patients with severe drug-refractory focal epilepsy (DRE) who started perampanel (PER) as add-on treatment, and to identify possible predisposing factors. Data on 49 consecutive patients with severe DRE who initiated PER were retrospectively collected. Twelve of the 49 patients experienced aggressiveness as adverse event related to PER treatment, one third of them on low (2-4 mg/day) PER dosages. PER was discontinued in 10/12 patients because of aggressive behaviors...
October 2017: Functional Neurology
Damiana Scuteri, B Piro, Luigi Antonio Morrone, Maria Tiziana Corasaniti, M Vulnera, G Bagetta
The Authors of this letter look at consumption of opioids and a2- ligands, also known as "gabapentinoids", in Italy, and specifically in the Provincial Health District of Cosenza, as compared with USA trends of recent decades. Access to analgesic drugs since the introduction of Italian law 38/2010 is also evaluated and possible future measures for better management of chronic pain are proposed.
October 2017: Functional Neurology
S F Castiglia, G Galeoto, A Lauta, A Palumbo, F Tirinelli, F Viselli, Valter Santilli, M L Sacchetti
The Barthel Index (BI) is widely used to determine eligibility criteria for inpatient rehabilitation and to monitor patients' recovery, irrespective of the illnesses that affect them. The culturally adapted Italian version of the Barthel Index (IcaBI) was recently validated. This paper reports the structural validity and inter-rater reliability of the IcaBI and its responsiveness to the results of inpatient rehabilitation. The IcaBI was administered to a cohort of 264 patients hospitalized in two rehabilitation centers in Rome, Italy...
October 2017: Functional Neurology
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