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Functional Neurology

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https://www.readbyqxmd.com/read/28676144/ixcellence-network%C3%A2-an-international-educational-network-to-improve-current-practice-in-the-management-of-cervical-dystonia-or-spastic-paresis-by-botulinum-toxin-injection
#1
Klemens Fheodoroff, Roongroj Bhidayasiri, Luis Jorge Jacinto, Tae Mo Chung, Kailash Bhatia, Therese Landreau, Carlo Colosimo
Botulinum toxin is a well-established treatment for a number of conditions involving muscle hyperactivity, such as focal dystonia and spastic paresis. However, current injection practice is not standardized and there is a clear need for structured training. An international group of experts in the management of patients with cervical dystonia (CD) and spastic paresis created a steering committee (SC). For each therapeutic area, the SC developed a core slide set on best practice, based on the literature. International sites of expertise were identified for training and courses were designed to include lectures and casebased learning...
April 2017: Functional Neurology
https://www.readbyqxmd.com/read/28676143/sensitivity-of-multi-shell-noddi-to-multiple-sclerosis-white-matter-changes-a-pilot-study
#2
Torben Schneider, W Brownlee, H Zhang, Olga Ciccarelli, David H Miller, Claudia Gandini Wheeler-Kingshott
Diffusion tensor imaging (DTI) is sensitive to white matter (WM) damage in multiple sclerosis (MS), not only in focal lesions but also in the normal-appearing WM (NAWM). However, DTI indices can also be affected by natural spatial variation in WM, as seen in crossing and dispersing white matter fibers. Neurite orientation dispersion and density imaging (NODDI) is an advanced diffusion-weighted imaging technique that provides distinct indices of fiber density and dispersion. We performed NODDI of lesion tissue and NAWM in five MS patients and five controls, comparing the technique with traditional DTI...
April 2017: Functional Neurology
https://www.readbyqxmd.com/read/28676142/the-italian-real-life-post-stroke-spasticity-survey-unmet-needs-in-the-management-of-spasticity-with-botulinum-toxin-type-a
#3
A Picelli, A Baricich, C Cisari, Stefano Paolucci, Nicola Smania, Giorgio Sandrini
The present national survey seeking to identify unmet needs in the management of spasticity with botulinum toxin type A focused on the use of OnabotulinumoxinA, since this is the brand with the widest range of licensed indications in Italy. Physicians from twenty-four Italian neurorehabilitation units compiled a questionnaire about "real-life" post-stroke spasticity management. OnabotulinumtoxinA was reported to be used in the following average doses: upper limb 316.7 ± 79.1 units; lower limb 327.8 ± 152...
April 2017: Functional Neurology
https://www.readbyqxmd.com/read/28676141/hla-drb1-15-association-with-multiple-sclerosis-is-confirmed-in-a-multigenerational-italian-family
#4
L Mosca, V Mantero, S Penco, L La Mantia, S De Benedetti, M R Marazzi, C Spreafico, C Erminio, L Grassi, G Lando, M Zagaria, E Agostoni, A Protti
Environmental and genetic factors seem to play a pathogenetic role in multiple sclerosis (MS). The genetic component is partly suggested by familial aggregation of cases; however, MS families with affected subjects over different generations have rarely been described. The aim of this study was to report clinical and genetic features of a multigenerational MS family and to perform a review of the literature on this topic. We describe a multigenerational Italian family with six individuals affected by MS, showing different clinical and neuroradiological findings...
April 2017: Functional Neurology
https://www.readbyqxmd.com/read/28676140/cerebellar-transcranial-static-magnetic-field-stimulation-transiently-reduces-cerebellar-brain-inhibition
#5
Akiyoshi Matsugi, Y Okada
The aim of this study was to investigate whether transcranial static magnetic field stimulation (tSMS) delivered using a compact cylindrical NdFeB magnet over the cerebellum modulates the excitability of the cerebellum and contralateral primary motor cortex, as measured using cerebellar brain inhibition (CBI), motor evoked potentials (MEPs), and resting motor threshold (rMT). These parameters were measured before tSMS or sham stimulation and immediately, 5 minutes and 10 minutes after stimulation. There were no significant changes in CBI, MEPs or rMT over time in the sham stimulation condition, and no changes in MEPs or rMT in the tSMS condition...
April 2017: Functional Neurology
https://www.readbyqxmd.com/read/28676139/object-decision-and-multiple-sclerosis-a-preliminary-study
#6
N Caputi, A Matrella, Rocco Totaro, C Raparelli, S Pontecorvo, D Di Giacomo, D Passafiume
The aim of this research was to study cognitive dysfunctions in multiple sclerosis (MS) by exploring subtle cognitive tasks, usually not included in the standard neuropsychological assessment. We wished to investigate whether it is possible to identify object decision deficits in MS patients without evident cognitive impairment; secondary objectives were to understand whether these deficits can be detected in the early stages of the disease and whether there are differences related to different phenotypes. Participants were divided into four groups: (a) 12 patients with early relapsing-remitting MS [ERR]; (b) 14 with late relapsing-remitting MS [LRR]; (c) 10 with secondary progressive MS [SP]; (d) 36 healthy controls [HCs]...
April 2017: Functional Neurology
https://www.readbyqxmd.com/read/28676138/european-core-curriculum-in-neurorehabilitation
#7
Giorgio Sandrini, H Binder, Volker Hömberg, Leopold Saltuari, I Tarkka, Nicola Smania, C Corradini, A Giustini, Christian Kätterer, L Picari, Karin Diserens, E Koenig, A Geurts, Aurelian Anghelescu, Józef Opara, P Tonin, Gert Kwakkel, Volodymyr Golyk, G Onose, Dominique Pérennou, A Picelli
To date, medical education lacks Europe-wide standards on neurorehabilitation. To address this, the European Federation of NeuroRehabilitation Societies (EFNR) here proposes a postgraduate neurorehabilitation training scheme. In particular, the European medical core curriculum in neurorehabilitation should include a two-year residency in a neurorehabilitation setting where trainees can gain practical experience. Furthermore, it should comprise six modules of classroom training organized as weekend seminars or summer/winter schools...
April 2017: Functional Neurology
https://www.readbyqxmd.com/read/28676137/the-past-and-future-of-functional-neurology
#8
EDITORIAL
E D'Angelo, F Boller, Claudia Gandini Wheeler-Kingshott, N Vanacore, Giorgio Sandrini, C Cisari, S Tamburin, Alessio Baricich
No abstract text is available yet for this article.
April 2017: Functional Neurology
https://www.readbyqxmd.com/read/28380325/in-the-face-of-pain-there-are-no-heroes-an-open-letter-to-the-members-of-the-european-parliament-about-ensuring-in-the-whole-europe-high-quality-care-research-equitable-employment-opportunities-and-socio-economic-support-for-cluster-headache-ch-pati
#9
https://www.readbyqxmd.com/read/28380324/a-15-year-epileptogenic-period-after-perinatal-brain-injury
#10
F Pisani, E Pavlidis, C Facini, C La Morgia, C Fusco, G Cantalupo
Seizures are a frequent acute neurological event in the neonatal period. Up to 12 to 18% of all seizures in newborns are due to perinatal stroke and up to 39% of affected children can then develop epilepsy in childhood. We report the case of a young patient who presented stroke-related seizures in the neonatal period and then developed focal symptomatic epilepsy at 15 years of age, and in whom the epileptic focus was found to co-localize with the site of his ischemic brain lesion. Such a prolonged silent period before onset of remote symptomatic epilepsy has not previously been reported...
January 2017: Functional Neurology
https://www.readbyqxmd.com/read/28380323/a-retrospective-analysis-of-254-acute-stroke-cases-admitted-to-two-university-hospitals-in-beirut-classification-and-associated-factors
#11
N Lahoud, Marie-Helene Abbas, Pascale Salameh, N Saleh, Samer Abes, Hassan Hosseini, Souheil Gebeily
Lebanon is a developing country where the prevalence of stroke subtypes and their correlation with risk factors have not been studied, even though stroke management is an ongoing major national healthcare challenge. In a retrospective study conducted in two university hospitals, data were collected on all stroke cases admitted in 2012 and 2013. Ischemic strokes were then classified according to a modified TOAST classification. A total of 254 inpatients (mean age 68.41 years ±13.34, 55.1% males) was included in the study; of these, 15% had had a hemorrhagic stroke and was therefore excluded...
January 2017: Functional Neurology
https://www.readbyqxmd.com/read/28380322/vitamin-d-in-amyotrophic-lateral-sclerosis
#12
L Libonati, E Onesti, M C Gori, Mauro Ceccanti, C Cambieri, A Fabbri, V Frasca, M Inghilleri
Vitamin D supplementation has been proposed as a potential treatment to delay amyotrophic lateral sclerosis (ALS) progression. The aims of this study were to compare retrospectively vitamin D blood levels in ALS patients with those in healthy subjects; to correlate vitamin D blood levels with clinical functions in patients; and to evaluate whether administration of vitamin D could modify the clinical progression of the disease. Vitamin D blood levels were evaluated in 57ALS patients and in 57 healthy subjects...
January 2017: Functional Neurology
https://www.readbyqxmd.com/read/28380321/gait-analysis-and-clinical-correlations-in-early-parkinson-s-disease
#13
M Pistacchi, M Gioulis, F Sanson, E De Giovannini, G Filippi, F Rossetto, S Zambito Marsala
The aim of our study was to identify and quantify spatiotemporal and kinematic gait parameters obtained by 3D gait analysis (GA) in a group of Parkinson's disease (PD) patients compared with healthy subjects in order to investigate whether early PD patients could present an abnormal gait pattern. Forty-four patients affected by early-stage PD compared with a control group were analyzed. All participants were evaluated with 3D GA in the gait laboratory. The greatest significance in temporal parameters was found in cadence (102...
January 2017: Functional Neurology
https://www.readbyqxmd.com/read/28380320/reappraisal-of-the-f-m-amplitude-ratio-in-carpal-tunnel-syndrome
#14
F Ginanneschi, M Mondelli, A Aretini, Alessandro Rossi
The F-wave/M-wave amplitude (F/M-amp) ratio has been shown to be increased in peripheral neuropathies, provided the maximum M-wave is relatively preserved. Reduced M-wave amplitudes and central facilitation of antidromically-induced reactivation of the anterior horn cells' axon hillocks (F-wave) are believed to contribute to higher F/M-amp ratios. The present study was undertaken to re-evaluate mechanisms responsible for higher F/M-amp ratios in carpal tunnel syndrome (CTS). We enrolled 232 cases affected by CTS and 108 controls...
January 2017: Functional Neurology
https://www.readbyqxmd.com/read/28380319/the-coefficient-of-friction-in-parkinson-s-disease-gait
#15
Ana Kleiner, M Galli, M Franceschini, M F De Pandis, F Stocchi, G Albertini, Ricardo Machado Leite de Barros
This study aimed to characterize the coefficient of friction (COF) curves of patients with Parkinson's disease (PD) during barefoot gait and to evaluate the relationships between this variable and functional scales. Twenty-two subjects with PD (ON phase of levodopa) and 22 healthy subjects participated in this study. The participants walked barefoot along a pathway that went over two force plates embedded in the floor of the data collection room. The instantaneous COF was calculated as the ratio between the horizontal and vertical components of the ground reaction forces...
January 2017: Functional Neurology
https://www.readbyqxmd.com/read/28380318/recent-advances-in-the-molecular-genetics-of-frontotemporal-lobar-degeneration
#16
REVIEW
Innocenzo Rainero, E Rubino, A Michelerio, F D'Agata, Salvatore Gentile, Lorenzo Pinessi
The term frontotemporal lobar degeneration (FTLD) describes a spectrum of neurodegenerative disorders associated with deposition of misfolded proteins in the frontal and temporal lobes. Up to 40% of FTLD patients reports a family history of neurodegeneration, and approximately 1/3 of familial cases shows an autosomal dominant pattern of inheritance of the phenotype. Over the past two decades, several causative and susceptibility genes for FTLD have been discovered, supporting the notion that genetic factors are important contributors to the disease processes...
January 2017: Functional Neurology
https://www.readbyqxmd.com/read/28380317/back-to-the-future-30th-anniversary-of-deep-brain-stimulation-for-parkinson-s-disease
#17
EDITORIAL
N G Pozzi, Claudio Pacchetti
No abstract text is available yet for this article.
January 2017: Functional Neurology
https://www.readbyqxmd.com/read/27976608/network-functional-connectivity-and-whole-brain-functional-connectomics-to-investigate-cognitive-decline-in-neurodegenerative-conditions
#18
O Dipasquale, Mara Cercignani
Non-invasive mapping of brain functional connectivity (FC) has played a fundamental role in neuroscience, and numerous scientists have been fascinated by its ability to reveal the brain's intricate morphology and functional properties. In recent years, two different techniques have been developed that are able to explore FC in pathophysiological conditions and to provide simple and non-invasive biomarkers for the detection of disease onset, severity and progression. These techniques are independent component analysis, which allows a network-based functional exploration of the brain, and graph theory, which provides a quantitative characterization of the whole-brain FC...
December 15, 2016: Functional Neurology
https://www.readbyqxmd.com/read/27976607/the-challenge-of-in-vivo-tissue-characterization-connectivity-and-big-data
#19
C Gandini Wheeler-Kingshott
No abstract text is available yet for this article.
December 15, 2016: Functional Neurology
https://www.readbyqxmd.com/read/27938528/modeling-white-matter-microstructure
#20
T Duval, N Stikov, J Cohen-Adad
Quantitative magnetic resonance imaging can be combined with advanced biophysical models to measure microstructural features of white matter. Non-invasive microstructural imaging has the potential to revolutionize neuroscience, and acquiring these measures in clinically feasible times would greatly improve patient monitoring and clinical studies of drug efficacy. However, a good understanding of microstructural imaging techniques is essential to set realistic expectations and to prevent over-interpretation of results...
December 12, 2016: Functional Neurology
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