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Functional Neurology

Paolo Rossi, S Bruce, M A De Pascual, H Muller, Ewa Kalina Tyminski, E R De La Torre
No abstract text is available yet for this article.
July 2018: Functional Neurology
F Battista, E Tinella, Carlo Colosimo
No abstract text is available yet for this article.
July 2018: Functional Neurology
R G Gatto, S M Mustafi, M Y Amin, T H Mareci, Yu-Chien Wu, R L Magin
Neurite orientation dispersion and density imaging (NODDI), a MRI multi-shell diffusion technique, has offered new insights for the study of microstructural changes in neurodegenerative diseases. Mainly, the present study aimed to determine the connection between NODDI-derived parameters and changes in white matter (WM) abnormalities at early stages of amyotrophic lateral sclerosis (ALS). Spinal cords from ALS mice (G93A-SOD1 mice) were scanned in a Bruker Avance III HD 17.6T magnet. Fluorescent axonal-tagged mice (YFP, G93A-SOD1 mice) were used for quantitative histological analysis...
July 2018: Functional Neurology
H Famitafreschi, M Karimian
The ventral tegmental area (VTA) is a brain region recently shown to interfere with pain perception. According to previous studies, improvement of antioxidant defense mechanisms reduces pain. The aim of this study was to show that lack of social interaction influences oxidative stress in the VTA and that this results in increased pain tolerance. In this study, 21 male Sprague-Dawley rats were randomly divided into 2 groups: paired and socially isolated (SI). After one week of acclimatization, the SI rats were isolated for 14 days and the other rats were paired for the same period...
July 2018: Functional Neurology
T-D Dimitriou, Eleni Verykouki, John Papatriantafyllou, A Konsta, D Kazis, M Tsolaki
Agitation/aggressive behaviour is a common behavioural and psychological symptom in people with dementia (PwD), occurring with a frequency of between 13-50.4% according to recent studies, and the rate increases as the severity of cognitive decline increases. The burden on caregivers is considerable. This trial is a randomized controlled crossover trial conducted in Greece. The following measures were used: the Mini-Mental State Examination, Addenbrooke's Cognitive Examination Revised, Geriatric Depression Scale, Functional Rating Scale for Symptoms in Dementia and Neuropsychiatric Inventory...
July 2018: Functional Neurology
Ana Francisca Rozin Kleiner, Diana M Cubillos, C Pinto, A P Salazar, R R Marchese, R M L Barros, M Galli, A S Pagnussat
The required coefficient of friction (RCOF) is frequently reported in the literature as an indicator of slip propensity, a consequence of the collisional aspect of legged locomotion. Little is known about the RCOF in pathological gait. Therefore, this study aimed to quantify the RCOF in subjects with Parkinson's disease (PD) and freezing of gait (FOG) during the OFF-pharma phase, and to investigate the interplay between RCOF parameters and ankle kinematic and kinetic gait variables. Fourteen subjects with PD and 14 healthy age-matched subjects were instructed to walk barefoot at self-selected speed over a force platform...
July 2018: Functional Neurology
A Lupo, A M Cinnera, A Pucello, M Iosa, P Coiro, S Personeni, Francesca Gimigliano, Giovanni Iolascon, Stefano Paolucci, G Morone
Stroke patients have reduced balance and postural control that limits their activities of daily living and participation in social life. Recently, many exergaming systems based on video-biofeedback have been developed for balance training in neurological conditions, however their efficacy remains to be proven. The aim of this study was to investigate the effects on balance skills and patient compliance of biofeedback training based on inertial measurement units and exergaming in subacute stroke. The enrolled subjects were randomized into two groups: subjects allocated to the experimental group performed 10 sessions of biofeedback balance training using inertial sensors, whereas subjects allocated to the control group performed 10 sessions of conventional balance training...
July 2018: Functional Neurology
C Geroin, S Tamburin, G Pagano, Marialuisa Gandolfi, Michele Tinazzi
Drugs used for the treatment of chronic lumbosacral radicular pain (LRP) may have frequent adverse effects leading to medication withdrawal. The use of add-on nutraceuticals, which have no side effects, may therefore play a role in LRP treatment. We performed a six-week, single-center, open label prospective uncontrolled clinical study to evaluate the effect of a nutraceutical combination (Noxiall®) used as an add-on therapy in patients with chronic LRP. Fifteen patients were treated with Noxiall® twice a day for 10 consecutive days, followed by once-daily administration up to the end of the six-week treatment...
July 2018: Functional Neurology
Alessio Baricich, S Carda
No abstract text is available yet for this article.
July 2018: Functional Neurology
S Liguori, A de Sire, A Moretti, L Sodano, S Sampaolo, Francesca Gimigliano, Giovanni Iolascon
No abstract text is available yet for this article.
April 2018: Functional Neurology
Alessio Baricich, L Cosenza, Giorgio Sandrini, Stefano Paolucci, G Morone, A Santamato, N Cinone, E Peri, A Picelli, M Invernizzi, G Ferriero
In the emerging scenario of patient-centered medicine, it is becoming increasingly important to involve patients in the management of chronic diseases. The rehabilitation field currently has no assessment tool for evaluating the functional impact of post-stroke spasticity on activities of daily living. The aim of this study was to identify a tool to fill this gap. The "Spasticity Questionnaire in Real Life" (SPQR) was administered, twice, to 39 patients with poststroke spasticity. Statistical analysis showed internal consistency and reliability of the questionnaire, with values greater than 0...
April 2018: Functional Neurology
M R Lo Monaco, A Laudisio, D Fusco, D L Vetrano, D Ricciardi, V Delle Donne, F Proietti, Giuseppe Zuccalà, Maria Caterina Silveri
Experimental evidence suggests that motor imagery (MI) engages the same neural substrates supporting actual motor activities and is likely impaired when such substrates are damaged, as in Parkinson's disease (PD). MI intuitively relies on visual imagery (VI), because mental simulations of physical movements depend on the visual retrieval of these movements. Although VI is generally considered a right hemispheric function, the hemispheric dominance of MI is still in dispute. Disparities in sidedness of motor disturbances are a distinctive feature of PD, and recent findings indicate that such disparities may similarly characterize cognition...
April 2018: Functional Neurology
R Avesani, F Dambruoso, M Scandola, Rita Formisano, Antonio De Tanti, S Ferro, Nicola Smania, L Roncari, E Rossato
Recent studies on recovery of consciousness of subjects in a vegetative state (VS) admitted to rehabilitation units have focused mainly on the identification of prognostic factors, whereas few studies have focused on outcome. The aim of this study was to compare demographic and clinical data and report functional outcome of patients in a VS due to severe acquired brain injury (ABI) of different aetiologies. The study was a retrospective multicentre cohort study and involved 492 patients in a VS due to traumatic (TBI) or non-traumatic (NTBI) severe ABI admitted to 29 Italian rehabilitation units...
April 2018: Functional Neurology
D Saviola, Antonio De Tanti, S Delsoldato, M Chiari, M G Inzaghi, F Baldari
Safe resumption of driving after a severe acquired brain injury (sABI) is a strongly felt need because driving is related to recovery of independence and social-occupational re-integration. The aim of this prospective observational cohort study was to determine whether epilepsy secondary to sABI is a significant factor for being declared fit to drive by the relevant government authorities in Italy. In the period 2006-2015 we recruited 187 patients with sABI, 30 of whom (16.4%) developed secondary epilepsy. The interval between the acute event and the first seizure varied widely (6-96 months), confirming the need for prolonged follow-up...
April 2018: Functional Neurology
Koichi Hiraoka, Yuki Kento, Hiroki Kiya, Yui Nozaki, Tatsuya Hayashi
This study looked for a direction-specific cortical response immediately after application of moving tactile stimuli in healthy female humans. Four pairs of stimulus electrodes were placed over the left index finger pulp on the distal-proximal axis. Four times, once in every 40 ms interval, an electrical stimulus to the finger pulp was delivered through one of the four pairs of electrodes; each time the stimulus site changed in order to induce a sensation of tactile motion. The slope of the electroencephalographic trace, as recorded from electrodes placed over the CP, P4 and right hMT+/V5 in the period 150-200 ms after the onset of stimuli delivered in sequence from the distal to proximal site, was significantly different from that after stimuli delivered in sequence from the proximal to distal site...
April 2018: Functional Neurology
A Zafar
Published studies have shown differences in types and underlying mechanisms of stroke between different regions of the world. There is a lack of published literature describing the characteristics of acute stroke in Saudi Arabia. The aim of this study was to identify different types and associated risk factors among acute stroke patients in Saudi Arabia. In this descriptive study, records of 500 patients with acute stroke were included. Acute stroke was classified as ischemic stroke, intracerebral hemorrhage, cerebral venous sinus thrombosis or subarachnoid hemorrhage...
April 2018: Functional Neurology
S A Gómez Ochoa, B B Espín Chico
Hyperglycemia-associated chorea-ballism (HCB) is an infrequent neurological syndrome whose pathophysiology remains poorly understood. Positron emission tomography (PET) studies have offered valuable information regarding regional glucose metabolism. The studies included were published between 1980-2017 and reported demographic, clinical, laboratory and imaging data from patients with HCB in whom a PET scan had been performed. Eleven patients were evaluated (women 82%, Asian origin 91%, mean age 71 years). The main findings were an increase in glucose metabolism at the contralateral motor cortex related to recent episodes of hemiballism-hemichorea in 2 patients, and an altered metabolism in the affected basal ganglia in all of them: decreased in 10 patients (91%) and increased in 1 (9%)...
April 2018: Functional Neurology
Rita Formisano, Marianna Contrada, Marta Aloisi
No abstract text is available yet for this article.
April 2018: Functional Neurology
Paolo Rossi, P Little, E R De La Torre, A Palmaro
Cluster headache (CH) is arguably the most severe pain condition that afflicts humans. The severity of the pain has earned it the nickname "suicide headache". Understanding how CH impacts on those who suffer from it is essential, because this understanding creates empathy, which is so valuable to these patients. On the occasion of Cluster Headache Day 2017, we asked CH patients from different European countries to share their experiences, in order to help people to imagine what it means to live with the condition...
January 2018: Functional Neurology
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