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Immunology and Cell Biology

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https://www.readbyqxmd.com/read/28925383/writer-s-block-preventing-m-6-a-mrna-methylation-promotes-t-cell-naivety
#1
Jonathan Sprent, Charles D Surh
No abstract text is available yet for this article.
September 19, 2017: Immunology and Cell Biology
https://www.readbyqxmd.com/read/28925382/modeling-primary-immune-regulatory-disorders-ferrari-or-yugo
#2
Michael B Jordan
No abstract text is available yet for this article.
September 19, 2017: Immunology and Cell Biology
https://www.readbyqxmd.com/read/28890536/a-key-role-for-il-7r-in-the-generation-of-microenvironments-required-for-thymic-dendritic-cells
#3
Amanda J Moore, Tracy Sh In, Ashton Trotman-Grant, Kogulan Yoganathan, Bertrand Montpellier, Cynthia J Guidos, Juan Carlos Zúñiga-Pflücker, Michele K Anderson
Interleukin-7 receptor (IL-7R) signaling is critical for multiple stages of T-cell development, but a role in the establishment of the mature thymic architecture needed for T-cell development and thymocyte selection has not been established. Crosstalk signals between developing thymocytes and thymic epithelial cell (TEC) precursors are critical for their differentiation into cortical TECs (cTECs) and medullary TECs (mTECs). Additionally, mTECs-derived factors have been implicated in the recruitment of thymic dendritic cells (DCs) and intrathymic DC development...
September 11, 2017: Immunology and Cell Biology
https://www.readbyqxmd.com/read/28878297/role-of-nf-%C3%AE%C2%BAb-gata3-in-the-inhibition-of-lysyl-oxidase-by-il-1%C3%AE-in-human-amnion-fibroblasts
#4
Chuyue Zhang, Wangsheng Wang, Chao Liu, Jiangwen Lu, Kang Sun
Preterm premature rupture of membranes (pPROM) accounts for one third of preterm births, a leading cause of neonatal death. Understanding the mechanism of membrane rupture is thus of clinical significance in the prevention of preterm birth. Parturition at both term and preterm is associated with increased abundance of proinflammatory cytokines in the fetal membranes regardless of the presence of infection, which is believed to induce rupture of membranes through activation of the matrix metalloproteinases. It remains unknown whether there are any alternative mechanisms underpinning proinflammatory cytokine-induced rupture of membranes...
September 7, 2017: Immunology and Cell Biology
https://www.readbyqxmd.com/read/28875978/il4-and-il21-cooperate-to-induce-the-high-bcl6-protein-level-required-for-germinal-center-formation
#5
Stéphane Chevrier, Tobias Kratina, Dianne Emslie, David M Tarlinton, Lynn M Corcoran
Bcl6 is a transcriptional repressor and critical mediator of the germinal center reaction during a T cell dependent antibody response, where it enables somatic hypermutation of immunoglobulin genes and inhibits terminal differentiation via repression of Blimp1. It can also contribute to the development of diffuse large B cell lymphoma when expressed inappropriately. Bcl6 regulation is mediated both at the transcriptional and post-transcriptional levels, and in particular a strong signal through the B cell receptor causes rapid proteasomal degradation of Bcl6...
September 6, 2017: Immunology and Cell Biology
https://www.readbyqxmd.com/read/28875977/the-life-and-death-of-immune-cell-types-the-role-of-bcl-2-anti-apoptotic-molecules
#6
REVIEW
Emma M Carrington, David M Tarlinton, Daniel H Gray, Nicholas D Huntington, Yifan Zhan, Andrew M Lew
Targeting survival mechanisms of immune cells may provide an avenue for immune intervention to dampen unwanted responses (e.g. autoimmunity, immunopathology and transplant rejection) or enhance beneficial ones (e.g. immune deficiency, microbial defence and cancer immunotherapy). The selective survival mechanisms of the various immune cell types also avails the possibility of specific tailoring of such interventions. Here, we review the role of the BCL-2 anti-apoptotic family members (BCL-2, BCL-XL, BCL-W, MCL-1 and A1) on cell death/survival of the major immune cell types e...
September 6, 2017: Immunology and Cell Biology
https://www.readbyqxmd.com/read/28829050/tamm-horsfall-glycoprotein-engages-human-siglec-9-to-modulate-neutrophil-activation-in-the-urinary-tract
#7
Kathryn A Patras, Alison Coady, Joshua Olson, Syed Raza Ali, Satish P RamachandraRao, Satish Kumar, Ajit Varki, Victor Nizet
Urinary tract infections are a major problem in human medicine for which better understanding of native immune defenses may reveal new pathways for therapeutic intervention. Tamm-Horsfall glycoprotein (THP), the most abundant urinary protein, interacts with bacteria including uropathogenic Escherichia coli (UPEC) as well host immune cells. In addition to its well-studied functions to antagonize bacterial colonization, we hypothesize that THP serves a critical host defense function through innate immune modulation...
August 22, 2017: Immunology and Cell Biology
https://www.readbyqxmd.com/read/28829049/the-march-family-joins-the-antigen-cross-presentation-party
#8
Justine D Mintern, José A Villadangos
No abstract text is available yet for this article.
August 22, 2017: Immunology and Cell Biology
https://www.readbyqxmd.com/read/28829048/maintenance-of-pd-1-on-brain-resident-memory-cd8-t-cells-is-antigen-independent
#9
Shwetank, Hossam A Abdelsamed, Elizabeth L Frost, Heather M Schmitz, Taryn E Mockus, Ben A Youngblood, Aron E Lukacher
Infection of the central nervous system (CNS) by murine polyomavirus (MuPyV), a persistent natural mouse pathogen, establishes brain-resident memory CD8 T cells (bTRM) that uniformly and chronically express programmed cell death protein 1 (PD-1) irrespective of the expression of αE integrin CD103, a TRM cell marker. In contrast, memory antiviral CD8 T cells in the spleen are PD-1(-), despite viral loads being similar in both the brain and spleen during persistent infection. Repetitive antigen engagement is central to sustained PD-1 expression by T cells in chronic viral infections; however, recent evidence indicates that expression of inhibitory receptors, including PD-1, is part of the TRM differentiation program...
August 22, 2017: Immunology and Cell Biology
https://www.readbyqxmd.com/read/28811625/interleukin-7-in-the-transition-of-bone-marrow-progenitors-to-the-thymus
#10
Adam W Plumb, Abdalla Sheikh, Douglas A Carlow, Hermann J Ziltener, Ninan Abraham
Interleukin-7 (IL-7) is essential for the development of T cells in humans and mice where deficiencies in IL-7 signaling result in severe immunodeficiency. T cells require IL-7 at multiple points during development however it is unclear when IL-7 is first necessary. We observed that mice with impaired IL-7 signaling had a large reduction in the number of early thymic progenitors (ETPs) while mice that overexpress IL-7 had greatly increased numbers of ETPs. These results indicated that the development of ETPs is sensitive to IL-7...
August 16, 2017: Immunology and Cell Biology
https://www.readbyqxmd.com/read/28726770/a-model-for-the-regulation-of-follicular-dendritic-cells-predicts-invariant-reciprocal-time-decay-of-post-vaccine-antibody-response
#11
Anthony Almudevar
Follicular dendritic cells (FDC) play a crucial role in the regulation of humoral immunity. They are believed to be responsible for long-term persistence of antibody, due to their role in antibody response induction and their ability to retain antigen in immunogenic form for long periods. In this article, a regulatory control model is proposed which links persistence of humoral immunity with cellular processes associated with FDCs. The argument is comprised of three elements. The first is a literature review of population-level studies of post-vaccination antibody persistence...
July 20, 2017: Immunology and Cell Biology
https://www.readbyqxmd.com/read/28722020/a-critical-role-of-gas6-axl-signal-in-allergic-airway-responses-during-rsv-vaccine-enhanced-disease
#12
Takehiko Shibata, Manabu Ato
Respiratory syncytial virus (RSV) is a common virus that causes lower respiratory infections across a wide range of ages. A licensed RSV vaccine is not available because vaccination with formalin-inactivated RSV (FI-RSV) and the subsequent RSV infection cause not only insufficient induction of neutralizing antibodies but also severe allergic airway responses, termed FI-RSV vaccine enhanced disease (FI-RSV VED). However, the underlying mechanism has not been identified, although a Th2-biased immune response is known to be a hallmark of this disease...
July 19, 2017: Immunology and Cell Biology
https://www.readbyqxmd.com/read/28722019/sustained-accumulation-of-antigen-presenting-cells-after-infection-promotes-local-t-cell-immunity
#13
Nicholas Collins, Katharina Hochheiser, Francis R Carbone, Thomas Gebhardt
Antigen-presenting cells (APC) such as dendritic cells (DC) and macrophages are critical for T cell-mediated immunity. While it is established that memory T cells accumulate and persist in peripheral tissues after the resolution of infection, whether this is also the case for APC remains unclear. Here, we report that CCR2-dependent cells infiltrate skin during acute infection with herpes simplex virus (HSV)-1 and subsequently give rise to localized populations of dendritic cells and macrophages. These APC are found at elevated numbers at sites of resolved infection or inflammation compared to unaffected regions of skin...
July 19, 2017: Immunology and Cell Biology
https://www.readbyqxmd.com/read/28722018/a-pro-survival-role-for-the-intracellular-granzyme-b-inhibitor-serpinb9-in-natural-killer-cells-during-poxvirus-infection
#14
Matthew S Mangan, Carolina R Melo-Silva, Jennii Luu, Catherina H Bird, Aulikki Koskinen, Alexandra Rizzitelli, Monica Prakash, Katrina L Scarff, Arno Müllbacher, Matthias Regner, Phillip I Bird
Intracellular serpins are proposed to inactivate proteases released from lysosome-related organelles into the host cell interior, preventing cell death. Serpinb9 opposes the immune cytotoxic protease, granzyme B, and in a number of settings protects cells against granzyme B-mediated cell death. Using a knockout mouse line engineered to express green fluorescent protein under the serpbinb9 promoter, we demonstrate that serpinb9 is vital for host survival during Ectromelia virus infection by maintaining both mature NK cells, and activated CD8(+) T cells...
July 19, 2017: Immunology and Cell Biology
https://www.readbyqxmd.com/read/28722017/the-role-of-age-related-t-cell-differentiation-in-patients-with-renal-replacement-therapy
#15
Matthias Schaier, Angele Leick, Lorenz Uhlmann, Florian Kälble, Volker Eckstein, Anthony Ho, Stefan Meuer, Karsten Mahnke, Claudia Sommerer, Martin Zeier, Andrea Steinborn
Dialysis patients have deficiencies regarding the generation of immune responses and show an increased susceptibility for infections. Persisting uremic conditions are made responsible for the increased aging of their immune system. In this study, we analyzed whether age-related differences in the differentiation of both recent-thymic-emigrant-(RTE)-regulatory (Tregs) and RTE-responder T cells (Tresps) into CD31(-)-memory Tregs/Tresps led to differences in the suppressive activity of naïve and memory Tregs on autologous Tresps between healthy volunteers and dialysis patients...
July 19, 2017: Immunology and Cell Biology
https://www.readbyqxmd.com/read/28682305/ifn-%C3%AE-promotes-transendothelial-migration-of-cd4-t-cells-across-the-blood-brain-barrier
#16
Sandip Ashok Sonar, Shagufta Shaikh, Nupura Joshi, Ashwini N Atre, Girdhari Lal
Transendothelial migration (TEM) of Th1 and Th17 cells across the blood-brain barrier (BBB) plays a critical role in the development of experimental autoimmune encephalomyelitis (EAE). How cytokines produced by inflammatory Th1 and Th17 cells damage the endothelial BBB and promote transendothelial migration of immune cells into the central nervous system (CNS) during autoimmunity is not understood. We therefore investigated the effect of various cytokines on brain endothelial cells. Among the various cytokines tested, such as Th1 (IFN-γ, IL-1α, IL-1β, TNF-α, IL-12), Th2 (IL-3, IL-4, IL-6 and IL-13), Th17 (IL-17A, IL-17F, IL-21, IL-22, IL-23, GM-CSF) and Treg-specific cytokines (IL-10 and TGF-β), IFN-γ predominantly showed increased expression of ICAM-1, VCAM-1, MAdCAM-1, H2-K(b) and I-A(b) molecules on brain endothelial cells...
July 6, 2017: Immunology and Cell Biology
https://www.readbyqxmd.com/read/28652580/immunological-phenotype-of-the-murine-lrba-knockout
#17
Laura Gámez-Díaz, Julika Neumann, Fiona Jäger, Michele Proietti, Felicitas Felber, Pauline Soulas-Sprauel, Lisa Perruzza, Fabio Grassi, Tamara Kögl, Peter Aichele, Manfred Kilimann, Bodo Grimbacher, Sophie Jung
Biallelic mutations in the human Lipopolysaccharide Responsive Beige-like Anchor (LRBA) gene lead to a primary immunodeficiency known as LRBA deficiency, characterized by a broad range of clinical manifestations including autoimmunity, organomegaly, hypogammaglobulinemia and recurrent infections. Considering the phenotypic heterogeneity in patients and the severity of the disease, our aim was to assess the role of LRBA in immune cells and to understand the underlying pathomechanisms through the study of a Lrba knockout (Lrba(-/-)) mouse model...
June 27, 2017: Immunology and Cell Biology
https://www.readbyqxmd.com/read/28649995/cytokines-in-systemic-lupus-erythematosus-far-beyond-th1-th2-dualism
#18
Poliana Macedo Guimarães, Bruna Miglioranza Scavuzzi, Nicole Perugini Stadtlober, Lorena Flor da Rosa Santos Silva, Marcell Alysson Batisti Lozovoy, Tathiana Mayumi Veiga Iriyoda, Neide Tomimura Costa, Edna Maria Vissoci Reiche, Michael Maes, Isaias Dichi, Andréa Name Colado Simão
The aims of this study were to delineate cytokines profiles of systemic lupus erythematosus (SLE), construct prediction models for diagnosis and disease activity using those profiles, and to examine the associations between TNFB Ncol polymorphism, body mass index (BMI), and vitamin D levels with cytokine levels. 200 SLE patients and 196 healthy controls participated in this case-control study. Plasma cytokines levels of TNF-α, IFN-γ, IL-1β, IL- 4, IL-6, IL-10, IL-12, IL-17 were measured and cytokines profiles were computed...
June 26, 2017: Immunology and Cell Biology
https://www.readbyqxmd.com/read/28895588/immunology-cell-biology-publication-of-the-year-awards-2016
#19
EDITORIAL
Anne La Flamme
No abstract text is available yet for this article.
September 2017: Immunology and Cell Biology
https://www.readbyqxmd.com/read/28653669/dnk-cells-facilitate-the-interaction-between-trophoblastic-and-endothelial-cells-via-vegf-c-and-hgf
#20
Liyang Ma, Guanlin Li, Guangming Cao, Yuchun Zhu, Mei-Rong Du, Yangyu Zhao, Hao Wang, Yanlei Liu, Yanyan Yang, Yu-Xia Li, Da-Jin Li, Huixia Yang, Yan-Ling Wang
Decidual NK (dNK) cells, identified as CD56(bright)CD16(-)CD3(-), account for ~70% of lymphocytes within the uterine wall during early pregnancy. Accumulating evidence suggests that tight interactions between placental trophoblasts and dNK cells are critical for trophoblast cell differentiation. However, the underlying mechanism remains to be explored in detail. In the present study, conditioned medium (CM) was collected from cultured primary human dNK cells. Primary cytotrophoblasts (CTBs) or the human trophoblast cell line HTR8/SVneo was treated with dNK-CM and co-cultured with human umbilical vein endothelial cells (HUVECs) in a three-dimensional Matrigel scaffold, and the formation of tube structures was dynamically monitored with live cell imaging...
September 2017: Immunology and Cell Biology
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