journal
MENU ▼
Read by QxMD icon Read
search

Immunology and Cell Biology

journal
https://www.readbyqxmd.com/read/29768737/providence-of-cd25-kir-cd127-foxp3-cd8-t-cell-subset-determines-the-dynamics-of-tumor-immune-surveillance
#1
Sreeparna Chakraborty, Pushpak Bhattacharjee, Abir K Panda, Kirti Kajal, Sayantan Bose, Gaurisankar Sa
CD8+ T-regulatory cells are progressively emerging as crucial components of immune system. The previous report suggests the presence of FOXP3-positive CD8+ Treg cells, similar to CD4+ Tregs, in cancer patients which produce high levels of IL10 and TGFβ for its immunosuppressive activities. At an early stage of tumor development, we have identified a subset of FOXP3-negative CD8+ CD25+ KIR+ CD127- a Treg-like subset which is essentially IFNγ-positive. However, this early induced CD8+ CD25+ CD127- T cell subset certainly distinct from the IFNγ+ CD8+ T-effecter cells...
May 16, 2018: Immunology and Cell Biology
https://www.readbyqxmd.com/read/29758102/purine-metabolism-controls-innate-lymphoid-cell-function-and-protects-against-intestinal-injury
#2
Siobhan Crittenden, Ashleigh Cheyne, Alexander Adams, Thorsten Forster, Calum T Robb, Jennifer Felton, Gwo-Tzer Ho, Dominik Ruckerl, Adriano G Rossi, Stephen M Anderton, Peter Ghazal, Jack Satsangi, Sarah E Howie, Chengcan Yao
Inflammatory bowel disease (IBD) is a condition of chronic inflammatory intestinal disorder with increasing prevalence but limited effective therapies. The purine metabolic pathway is involved in various inflammatory processes including IBD. However, the mechanisms through which purine metabolism modulates IBD remain to be established. Here we found that mucosal expression of genes involved in the purine metabolic pathway is altered in patients with active ulcerative colitis (UC), which is associated with elevated gene expression signatures of the group 3 innate lymphoid cell (ILC3)-interleukin (IL)-22 pathway...
May 14, 2018: Immunology and Cell Biology
https://www.readbyqxmd.com/read/29754432/bim-determines-the-number-of-merocytic-dendritic-cells-a-cell-type-that-breaks-immune-tolerance
#3
Cindy Audiger, Sylvie Lesage
In contrast to conventional dendritic cells (cDC), when merocytic dendritic cells (mcDC) present antigens derived from apoptotic bodies, T cell anergy is reversed rather than induced, a process that promotes autoimmunity. Interestingly, mcDC are present in higher proportion in type 1 diabetes-prone NOD mice than in autoimmune-resistant B6 and BALB/c mice, and the Insulin-dependent diabetes 13 locus is linked to mcDC proportion. Therefore, mcDC are notably associated with susceptibility to autoimmune diabetes...
May 13, 2018: Immunology and Cell Biology
https://www.readbyqxmd.com/read/29754419/integration-of-t-cell-receptor-notch-and-cytokine-signals-programs-in-mouse-%C3%AE-%C3%AE-t-cell-effector-differentiation
#4
Payam Zarin, Tracy S H In, Edward L Y Chen, Jastaranpreet Singh, Gladys W Wong, Mahmood Mohtashami, David L Wiest, Michele K Anderson, Juan Carlos Zúñiga-Pflücker
γδ T-cells perform a wide range of tissue and disease specific functions that are dependent on the effector cytokines produced by these cells. However, the aggregate signals required for the development of interferon-γ (IFNγ) and interleukin-17 (IL-17) producing γδ T-cells remain unknown. Here, we define the cues involved in the functional programming of γδ T-cells, by examining the roles of T-cell receptor (TCR), Notch, and cytokine-receptor signaling. KN6 γδTCR-transduced Rag2-/- T-cell progenitors were cultured on stromal cells variably expressing TCR and Notch ligands, supplemented with different cytokines...
May 13, 2018: Immunology and Cell Biology
https://www.readbyqxmd.com/read/29744934/modelling-how-reversal-of-immune-exhaustion-elicits-cure-of-chronic-hepatitis-c-after-the-end-of-treatment-with-direct-acting-antiviral-agents
#5
Subhasish Baral, Rahul Roy, Narendra M Dixit
A fraction of chronic hepatitis C patients treated with direct-acting antivirals (DAAs) achieved sustained virological responses (SVR), or cure, despite having detectable viremia at the end of treatment (EOT). This observation, termed EOT+ /SVR, remains puzzling and precludes rational optimization of treatment durations. One hypothesis to explain EOT+ /SVR, the immunologic hypothesis, argues that the viral decline induced by DAAs during treatment reverses the exhaustion of cytotoxic T lymphocytes (CTLs), which then clear the infection after treatment...
May 9, 2018: Immunology and Cell Biology
https://www.readbyqxmd.com/read/29738615/apoptotic-vesicles-deathly-players-in-cancer-associated-coagulation
#6
M-R Muhsin-Sharafaldine, A D McLellan
Although cancer is associated with coagulation disorders, it is still unclear how the combination of tumour cell and host factors enhance the hypercoagulable state of cancer patients. Emerging evidence points to a central role for tumour endosomal and plasma-membrane derived vesicular components in the pathogenesis of cancer-related thrombosis. In particular, tumour cell membranes and extracellular vesicles (EV) harbour lipids and proteinaceous coagulation factors able to initiate multiple points within the coagulation matrix...
May 8, 2018: Immunology and Cell Biology
https://www.readbyqxmd.com/read/29738610/lmp2-immunoproteasome-promotes-lymphocyte-survival-by-degrading-apoptotic-bh3-only-proteins
#7
Damien Zanker, Kenneth Pang, Sara Oveissi, Chunni Lu, Pierre Faou, Cameron Nowell, George Williams Mbogo, Sebastian Carotta, Cathy Quillici, Guna Karupiah, Margaret Hibbs, Stephen L Nutt, Paul Neeson, Hamsa Puthalakath, Weisan Chen
The role of the immunoproteasome is perceived as confined to adaptive immune responses given its ability to produce peptides ideal for MHC Class-I binding. Here, we demonstrate that the immunoproteasome subunit, LMP2, has functions beyond its immunomodulatory role. Using LMP2-deficient mice, we demonstrate that LMP2 is crucial for lymphocyte development and survival in the periphery. Moreover, LMP2-deficient lymphocytes show impaired degradation of key BH3-only proteins, resulting in elevated levels of pro-apoptotic BIM and increased cell death...
May 8, 2018: Immunology and Cell Biology
https://www.readbyqxmd.com/read/29726044/%C3%AE-%C3%AE-t-cell-receptors-with-a-central-cdr3-cysteine-are-enriched-in-cd8%C3%AE-%C3%AE-intraepithelial-lymphocytes-and-their-thymic-precursors
#8
Rushika C Wirasinha, Mandeep Singh, Stuart K Archer, Anna Chan, Paul F Harrison, Christopher C Goodnow, Stephen R Daley
The thymus plays a crucial role in immune tolerance by exposing developing T cells (thymocytes) to a myriad of self-antigens. Strong T-cell receptor (TCR) engagement induces tolerance in self-reactive thymocytes by stimulating apoptosis or selection into specialized T-cell lineages, including intestinal TCRαβ+ CD8αα+ intraepithelial lymphocytes (IEL). TCR-intrinsic amino acid motifs that can be used to predict whether a TCR will be strongly self-reactive remain elusive. Here, a novel TCR sequence alignment approach revealed that T-cell lineages in C57BL/6 mice had divergent usage of cysteine within two positions of the amino acid at the apex of the complementarity-determining region 3 (CDR3) of the TCRα or TCRβ chain...
May 3, 2018: Immunology and Cell Biology
https://www.readbyqxmd.com/read/29697865/sjhsp60-induces-cd4-cd25-foxp3-tregs-via-tlr4-mal-drived-production-of-tgf-%C3%AE-in-macrophages
#9
Sha Zhou, Qianqian Qi, Xiaofan Wang, Lina Zhang, Lei Xu, Liyang Dong, Jifeng Zhu, Yalin Li, Xuefeng Wang, Zhipeng Xu, Feng Liu, Wei Hu, Liang Zhou, Xiaojun Chen, Chuan Su
CD4+ CD25+ Foxp3+ regulatory T cells (Tregs) play a pivotal role in limiting immunopathological damage to host organs after schistosome infection. TGF-β is an essential factor for the periphery conversion of CD4+ CD25- T cells into CD4+ CD25+ Foxp3+ Tregs by inducing the key transcription factor Foxp3. Antigen presenting cells (APCs), which highly express TGF-β, are involved in parasite antigen-induced Treg convertion in peripheral. However, the mechanisms underlying high TGF-β induction in APCs by parasite antigens remain to be clarified during schistosome infection...
April 26, 2018: Immunology and Cell Biology
https://www.readbyqxmd.com/read/29672927/interleukin-33-contributes-to-ilc2-activation-and-early-inflammation-associated-lung-injury-during-abdominal-sepsis
#10
Hui Xu, Jing Xu, Li Xu, Shuqing Jin, Heth R Turnquist, Rosemary Hoffman, Patricia Loughran, Timothy R Billiar, Meihong Deng
Sepsis is defined as infection with organ dysfunction due to a dysregulated immune response. The lung is one of the most vulnerable organs at the onset of sepsis. Interleukin-33 (IL-33) can be released by injured epithelial and endothelial cells in the lung and regulate immune activation and infiltration. Therefore, we postulated that IL-33 would contribute to the immune response in the lung during sepsis. Using the cecal ligation and puncture (CLP) sepsis model, we show here that IL-33 contributes significantly to both sepsis-induced inflammation in the lung and systemic inflammatory response in the early phase of sepsis...
April 19, 2018: Immunology and Cell Biology
https://www.readbyqxmd.com/read/29665088/gain-of-function-analysis-of-cis-acting-diversification-elements-in-dt40-cells
#11
Randolph B Caldwell, Herbert Braselmann, Steffen Heuer, Ulrike Schötz, Horst Zitzelsberger
Activation-induced cytidine deaminase (AID) is required for the immunoglobulin diversification processes of somatic hypermutation, gene conversion and class-switch recombination. The targeting of AID's deamination activity is thought to be a combination of cis- and trans-acting elements, but has not been fully elucidated. Deletion analysis of putative proximal cis-regulatory motifs, while helpful, fails to identify additive versus cumulative effects, redundancy, and may create new motifs where none previously existed...
April 17, 2018: Immunology and Cell Biology
https://www.readbyqxmd.com/read/29656544/an-overview-on-the-identification-of-mait-cell-antigens
#12
Lars Kjer-Nielsen, Alexandra J Corbett, Zhenjun Chen, Ligong Liu, Jeffrey Y W Mak, Dale I Godfrey, Jamie Rossjohn, David P Fairlie, James McCluskey, Sidonia B G Eckle
Mucosal Associated Invariant T (MAIT) cells are restricted by the monomorphic MHC class I-like molecule, MHC-related protein-1 (MR1). Until 2012, the origin of the MAIT cell antigens (Ags) was unknown, although it was established that MAIT cells could be activated by a broad range of bacteria and yeasts, possibly suggesting a conserved Ag. Using a combination of protein chemistry, mass spectrometry, cellular biology, structural biology and chemistry, we discovered MAIT cell ligands derived from folic acid (vitamin B9) and from an intermediate in the microbial biosynthesis of riboflavin (vitamin B2)...
April 14, 2018: Immunology and Cell Biology
https://www.readbyqxmd.com/read/29637611/the-changing-face-of-haematopoiesis-a-spectrum-of-options-is-available-to-stem-cells
#13
REVIEW
Geoffrey Brown, Panagiotis Tsapogas, Rhodri Ceredig
For more than 30 years the scheme whereby bone marrow haematopoietic stem cells give rise to the many different types of blood and immune cells has been represented as a lineage tree diagram. In this model, haematopoietic stem cells follow a preferred route to each of the end cell types and gradually restrict their other lineage options via a series of intermediate oligo-potent progenitors. Recent findings of lineage biases or affiliations within haematopoietic stem and progenitor cells that are either pluripotent or uni-potent show that a continuum of fate options is open to haematopoietic stem cells...
April 10, 2018: Immunology and Cell Biology
https://www.readbyqxmd.com/read/29635843/therapeutic-prospects-of-targeting-myeloid-derived-suppressor-cells-and-immune-checkpoints-in-cancer
#14
REVIEW
Salman M Toor, Eyad Elkord
Immune evasion is a characteristic of most human malignancies and is induced via various mechanisms. Immunosuppressive cells, including myeloid-derived suppressor cells (MDSC) and regulatory T cells (Treg), are key mediators in assisting tumors to escape immune surveillance. Expansion of MDSC, Treg and elevated levels of immune checkpoint (IC) are frequently detected in the tumor microenvironment (TME) and periphery of cancer patients. Various therapeutic agents have been shown to target MDSC and to block IC for inducing anti-tumor immunity and reversal of tumor immune escape...
April 10, 2018: Immunology and Cell Biology
https://www.readbyqxmd.com/read/29624724/inflammatory-compound-lipopolysaccharide-promotes-the-survival-of-gm-csf-cultured-dendritic-cell-via-pi3-kinase-dependent-up-regulation-of-bcl-x
#15
Shun Chen, Xinchen Li, Wenjie Zhang, Mengting Zi, Yuekang Xu
As professional antigen-presenting cells, dendritic cells (DCs) initiate and regulate immune responses against inflammation. The invasion of pathogens into the body, however, can in turn cause the change of DCs in both activity and viability, which ultimately affect immune homeostasis. The exact mechanisms that the bacteria utilize to alter the lifespan of DCs, however, are far from clear. In this study, we found that the bacterial wall compound lipopolysaccharide(LPS)can promote the survival of GM-CSF-differentiated DCs (GM-DCs)...
April 6, 2018: Immunology and Cell Biology
https://www.readbyqxmd.com/read/29617057/antigen-specific-helios-neuropilin-1-tregs-induce-apoptosis-of-autoreactive-b-cells-via-pd-l1
#16
Janine Gotot, Ermanila Dhana, Hideo Yagita, Romina Kaiser, Isis Ludwig-Portugall, Christian Kurts
Regulatory T cells (Tregs) maintain self-tolerance and prevent autoimmunity by controlling autoreactive T cells. We recently demonstrated in vivo that Tregs can directly suppress auto-reactive B cells via programmed death ligand 1 (PD-L1) that ligated PD-1 on B cells and caused them to undergo apoptosis. Here we asked whether this mechanism is utilized by thymus-derived natural Tregs and/or by peripheral lymphoid tissue-induced Tregs. We first demonstrated that antigen-specific PD-L1-expressing Tregs were induced in the draining lymph node (LN) of autoantigen-expressing tissue and characterized them by their lack of the transcription factor Helios and of the surface marker Neuropilin-1 (Nrp-1)...
April 4, 2018: Immunology and Cell Biology
https://www.readbyqxmd.com/read/29617041/direct-binding-and-internalization-of-diverse-extracellular-nucleic-acid-species-through-the-collagenous-domain-of-class-a-scavenger-receptors
#17
Kaushal Baid, Srinivas Nellimarla, Angela Huynh, Stephen Boulton, Alba Guarné, Giuseppe Melacini, Susan E Collins, Karen L Mossman
Nucleic acids are potential pathogen-associated or danger-associated molecular patterns that modulate immune responses and the development of autoimmune disorders. Class A scavenger receptors (SR-As) are a diverse group of pattern recognition receptors (PRRs) that recognize a variety of polyanionic ligands including nucleic acids. While SR-As are important for the recognition and internalization of extracellular dsRNA, little is known about extracellular DNA, despite its association with chronic infections and autoimmune disorders...
April 4, 2018: Immunology and Cell Biology
https://www.readbyqxmd.com/read/29611236/ifn%C3%AE-inhibits-the-development-of-allergen-tolerance-and-is-conducive-to-the-development-of-asthma-on-subsequent-allergen-exposure
#18
Vanessa S Fear, Matthew W-P Poh, Shelley Gorman, Jason C Waithman, Mark W Fear
Asthma is a chronic disease affecting up to 10% of the Australian population for which medical treatment is solely aimed at relief of symptoms rather than prevention of disease. Evidence from animal and human studies demonstrates a strong link between viral respiratory infections, atopy and the development of asthma. Type I IFNs include IFNα and IFNβ, with subtype expression tailored toward the specific viral infection. We hypothesized that exposure to Type I IFNs and allergen may interfere with the healthy response to innocuous airway antigen exposure...
April 2, 2018: Immunology and Cell Biology
https://www.readbyqxmd.com/read/29604105/xenopus-laevis-macrophage-like-cells-produce-xcl-1-an-intelectin-family-serum-lectin-that-recognizes-bacteria
#19
Saburo Nagata
Xenopus laevis Ca2+ -dependent lectin-1 (XCL-1) is an intelectin family serum lectin that selectively recognizes carbohydrate chains on the bacterial cell surface. Immunofluorescence examination of control spleen tissues from normal X. laevis revealed cells producing XCL-1 (XCL-1+ cells) exclusively in red pulps. Intraperitoneal injection of Escherichia coli lipopolysaccharide (LPS) caused a marked increase in the number of XCL-1+ cells in red pulps on day 3, followed by a rapid decrease to near control levels by day 7...
March 31, 2018: Immunology and Cell Biology
https://www.readbyqxmd.com/read/29604098/immunological-effects-of-placental-extracellular-vesicles
#20
Mancy Tong, Vikki M Abrahams, Lawrence W Chamley
Extracellular vesicles (EVs) extruded by the human placenta are increasingly being recognised as an essential mode of feto-maternal communication. In the past two decades, there has been an explosion of research into the roles that placental EVs play in modulating the maternal immune and cardiovascular systems during healthy pregnancies, as well as how this communication is altered in obstetric diseases. This review aims to introduce readers to the processes of placental EV formation and the cargos they carry, and also to collate and summarise the published literature that investigates the immunological effects of placental EVs throughout human pregnancy...
March 31, 2018: Immunology and Cell Biology
journal
journal
29544
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"