journal
MENU ▼
Read by QxMD icon Read
search

Immunology and Cell Biology

journal
https://www.readbyqxmd.com/read/29066798/embracing-diversity-gives-antibodies-the-power-to-bind
#1
Henry J Sutton, Marion Pepper, Ian A Cockburn
No abstract text is available yet for this article.
October 24, 2017: Immunology and Cell Biology
https://www.readbyqxmd.com/read/28994418/ptpn2-a-tumor-suppressor-you-want-deleted
#2
Florian Wiede, Tony Tiganis
No abstract text is available yet for this article.
October 10, 2017: Immunology and Cell Biology
https://www.readbyqxmd.com/read/28878297/role-of-nf-%C3%AE%C2%BAb-gata3-in-the-inhibition-of-lysyl-oxidase-by-il-1%C3%AE-in-human-amnion-fibroblasts
#3
Chuyue Zhang, Wangsheng Wang, Chao Liu, Jiangwen Lu, Kang Sun
Preterm premature rupture of membranes (pPROMs) account for one-third of preterm births, a leading cause of neonatal death. Understanding the mechanism of membrane rupture is thus of clinical significance in the prevention of preterm birth. Parturition at both term and preterm is associated with increased abundance of proinflammatory cytokines in the fetal membranes regardless of the presence of infection, which is believed to induce rupture of membranes through activation of the matrix metalloproteinases. It remains unknown whether there are any alternative mechanisms underpinning proinflammatory cytokine-induced rupture of membranes...
October 3, 2017: Immunology and Cell Biology
https://www.readbyqxmd.com/read/28948981/pd-1-always-on-my-mind
#4
Simone L Park, Laura K Mackay
No abstract text is available yet for this article.
September 26, 2017: Immunology and Cell Biology
https://www.readbyqxmd.com/read/28925383/writer-s-block-preventing-m-6-a-mrna-methylation-promotes-t-cell-naivety
#5
Jonathan Sprent, Charles D Surh
No abstract text is available yet for this article.
September 19, 2017: Immunology and Cell Biology
https://www.readbyqxmd.com/read/28890536/a-key-role-for-il-7r-in-the-generation-of-microenvironments-required-for-thymic-dendritic-cells
#6
Amanda J Moore, Tracy Sh In, Ashton Trotman-Grant, Kogulan Yoganathan, Bertrand Montpellier, Cynthia J Guidos, Juan Carlos Zúñiga-Pflücker, Michele K Anderson
Interleukin-7 receptor (IL-7R) signaling is critical for multiple stages of T-cell development, but a role in the establishment of the mature thymic architecture needed for T-cell development and thymocyte selection has not been established. Crosstalk signals between developing thymocytes and thymic epithelial cell (TEC) precursors are critical for their differentiation into cortical TECs (cTECs) and medullary TECs (mTECs). In addition, mTEC-derived factors have been implicated in the recruitment of thymic dendritic cells (DCs) and intrathymic DC development...
September 11, 2017: Immunology and Cell Biology
https://www.readbyqxmd.com/read/28875978/il4-and-il21-cooperate-to-induce-the-high-bcl6-protein-level-required-for-germinal-center-formation
#7
Stéphane Chevrier, Tobias Kratina, Dianne Emslie, David M Tarlinton, Lynn M Corcoran
Bcl6 is a transcriptional repressor and critical mediator of the germinal center reaction during a T cell dependent antibody response, where it enables somatic hypermutation of immunoglobulin genes and inhibits terminal differentiation via repression of Blimp1. It can also contribute to the development of diffuse large B cell lymphoma when expressed inappropriately. Bcl6 regulation is mediated both at the transcriptional and post-transcriptional levels, and in particular a strong signal through the B cell receptor causes rapid proteasomal degradation of Bcl6...
September 6, 2017: Immunology and Cell Biology
https://www.readbyqxmd.com/read/28875977/the-life-and-death-of-immune-cell-types-the-role-of-bcl-2-anti-apoptotic-molecules
#8
REVIEW
Emma M Carrington, David M Tarlinton, Daniel H Gray, Nicholas D Huntington, Yifan Zhan, Andrew M Lew
Targeting survival mechanisms of immune cells may provide an avenue for immune intervention to dampen unwanted responses (e.g. autoimmunity, immunopathology and transplant rejection) or enhance beneficial ones (e.g. immune deficiency, microbial defence and cancer immunotherapy). The selective survival mechanisms of the various immune cell types also avails the possibility of specific tailoring of such interventions. Here, we review the role of the BCL-2 anti-apoptotic family members (BCL-2, BCL-XL, BCL-W, MCL-1 and A1) on cell death/survival of the major immune cell types e...
September 6, 2017: Immunology and Cell Biology
https://www.readbyqxmd.com/read/28829050/tamm-horsfall-glycoprotein-engages-human-siglec-9-to-modulate-neutrophil-activation-in-the-urinary-tract
#9
Kathryn A Patras, Alison Coady, Joshua Olson, Syed Raza Ali, Satish P RamachandraRao, Satish Kumar, Ajit Varki, Victor Nizet
Urinary tract infections are a major problem in human medicine for which better understanding of native immune defenses may reveal new pathways for therapeutic intervention. Tamm-Horsfall glycoprotein (THP), the most abundant urinary protein, interacts with bacteria including uropathogenic Escherichia coli (UPEC) as well host immune cells. In addition to its well-studied functions to antagonize bacterial colonization, we hypothesize that THP serves a critical host defense function through innate immune modulation...
August 22, 2017: Immunology and Cell Biology
https://www.readbyqxmd.com/read/28829048/maintenance-of-pd-1-on-brain-resident-memory-cd8-t-cells-is-antigen-independent
#10
Shwetank, Hossam A Abdelsamed, Elizabeth L Frost, Heather M Schmitz, Taryn E Mockus, Ben A Youngblood, Aron E Lukacher
Infection of the central nervous system (CNS) by murine polyomavirus (MuPyV), a persistent natural mouse pathogen, establishes brain-resident memory CD8 T cells (bTRM) that uniformly and chronically express programmed cell death protein 1 (PD-1) irrespective of the expression of αE integrin CD103, a TRM cell marker. In contrast, memory antiviral CD8 T cells in the spleen are PD-1(-), despite viral loads being similar in both the brain and spleen during persistent infection. Repetitive antigen engagement is central to sustained PD-1 expression by T cells in chronic viral infections; however, recent evidence indicates that expression of inhibitory receptors, including PD-1, is part of the TRM differentiation program...
August 22, 2017: Immunology and Cell Biology
https://www.readbyqxmd.com/read/28948982/preparing-for-re-entry-is-sequential-switching-the-result-of-recurrent-secondary-responses
#11
Kim L Good-Jacobson
No abstract text is available yet for this article.
October 2017: Immunology and Cell Biology
https://www.readbyqxmd.com/read/28925382/modeling-primary-immune-regulatory-disorders-ferrari-or-yugo
#12
Michael B Jordan
No abstract text is available yet for this article.
October 2017: Immunology and Cell Biology
https://www.readbyqxmd.com/read/28829049/the-march-family-joins-the-antigen-cross-presentation-party
#13
Justine D Mintern, José A Villadangos
No abstract text is available yet for this article.
October 2017: Immunology and Cell Biology
https://www.readbyqxmd.com/read/28726770/a-model-for-the-regulation-of-follicular-dendritic-cells-predicts-invariant-reciprocal-time-decay-of-post-vaccine-antibody-response
#14
Anthony Almudevar
Follicular dendritic cells (FDC) play a crucial role in the regulation of humoral immunity. They are believed to be responsible for long-term persistence of antibody, due to their role in antibody response induction and their ability to retain antigen in immunogenic form for long periods. In this article, a regulatory control model is proposed which links persistence of humoral immunity with cellular processes associated with FDCs. The argument comprises three elements. The first is a literature review of population-level studies of post-vaccination antibody persistence...
October 2017: Immunology and Cell Biology
https://www.readbyqxmd.com/read/28682305/ifn-%C3%AE-promotes-transendothelial-migration-of-cd4-t-cells-across-the-blood-brain-barrier
#15
Sandip Ashok Sonar, Shagufta Shaikh, Nupura Joshi, Ashwini N Atre, Girdhari Lal
Transendothelial migration (TEM) of Th1 and Th17 cells across the blood-brain barrier (BBB) has a critical role in the development of experimental autoimmune encephalomyelitis (EAE). How cytokines produced by inflammatory Th1 and Th17 cells damage the endothelial BBB and promote transendothelial migration of immune cells into the central nervous system (CNS) during autoimmunity is not understood. We therefore investigated the effect of various cytokines on brain endothelial cells. Among the various cytokines tested, such as Th1 (IFN-γ, IL-1α, IL-1β, TNF-α, IL-12), Th2 (IL-3, IL-4, IL-6 and IL-13), Th17 (IL-17A, IL-17F, IL-21, IL-22, IL-23, GM-CSF) and Treg-specific cytokines (IL-10 and TGF-β), IFN-γ predominantly showed increased expression of ICAM-1, VCAM-1, MAdCAM-1, H2-K(b) and I-A(b) molecules on brain endothelial cells...
October 2017: Immunology and Cell Biology
https://www.readbyqxmd.com/read/28652580/immunological-phenotype-of-the-murine-lrba-knockout
#16
Laura Gámez-Díaz, Julika Neumann, Fiona Jäger, Michele Proietti, Felicitas Felber, Pauline Soulas-Sprauel, Lisa Perruzza, Fabio Grassi, Tamara Kögl, Peter Aichele, Manfred Kilimann, Bodo Grimbacher, Sophie Jung
Biallelic mutations in the human lipopolysaccharide responsive beige-like anchor (LRBA) gene lead to a primary immunodeficiency known as LRBA deficiency, characterized by a broad range of clinical manifestations including autoimmunity, organomegaly, hypogammaglobulinemia and recurrent infections. Considering the phenotypic heterogeneity in patients and the severity of the disease, our aim was to assess the role of LRBA in immune cells and to understand the underlying pathomechanisms through the study of a Lrba knockout (Lrba(-/-)) mouse model...
October 2017: Immunology and Cell Biology
https://www.readbyqxmd.com/read/28649995/cytokines-in-systemic-lupus-erythematosus-far-beyond-th1-th2-dualism-lupus-cytokine-profiles
#17
Poliana Macedo Guimarães, Bruna Miglioranza Scavuzzi, Nicole Perugini Stadtlober, Lorena Flor da Rosa Franchi Santos, Marcell Alysson Batisti Lozovoy, Tatiana Mayumi Veiga Iriyoda, Neide Tomimura Costa, Edna Maria Vissoci Reiche, Michael Maes, Isaias Dichi, Andréa Name Colado Simão
The aims of this study were to delineate cytokine profiles of systemic lupus erythematosus (SLE), construct prediction models for diagnosis and disease activity using those profiles, and to examine the associations between TNFB Ncol polymorphism, body mass index (BMI) and vitamin D levels with cytokine levels. Two hundred SLE patients and 196 healthy controls participated in this case-control study. Plasma cytokines levels of tumor necrosis factor (TNF)-α, interferon (IFN)-γ, interleukin (IL)-1β, IL- 4, IL-6, IL-10, IL-12 and IL-17 were measured and cytokines profiles were computed...
October 2017: Immunology and Cell Biology
https://www.readbyqxmd.com/read/28611475/murine-lrba-deficiency-causes-ctla-4-deficiency-in-tregs-without-progression-to-immune-dysregulation
#18
Deborah L Burnett, Ian A Parish, Etienne Masle-Farquhar, Robert Brink, Christopher C Goodnow
Inherited mutations in lipopolysaccharide-responsive beige-like anchor (LRBA) cause a recessive human immune dysregulation syndrome with memory B-cell and antibody deficiency (common variable immunodeficiency), inflammatory bowel disease, enlarged spleen and lymph nodes, accumulation of activated T cells and multiple autoimmune diseases. To understand the pathogenesis of the syndrome, C57BL/6 mice carrying a homozygous truncating mutation in Lrba were produced using CRISPR/Cas9-mediated gene targeting. These mice revealed that LRBA has a critical, cell-autonomous role in promoting cytotoxic T-lymphocyte antigen-4 (CTLA-4) accumulation within CD4 effector T cells and FOXP3(+) T-regulatory cells (Tregs)...
October 2017: Immunology and Cell Biology
https://www.readbyqxmd.com/read/28611474/p38%C3%AE-regulates-cytokine-induced-ifn%C3%AE-secretion-via-the-mnk1-eif4e-pathway-in-th1-cells
#19
María Salvador-Bernáldez, Sara B Mateus, Iván Del Barco Barrantes, Simon C Arthur, Carlos Martínez-A, Angel R Nebreda, Jesús M Salvador
The p38 mitogen-activated protein kinase (MAPK) pathway is involved in the regulation of immune and inflammatory processes. We used p38α-conditional, p38β-deficient and p38α/β double-null mouse models to address the role of these two p38 MAPK in CD4(+) T cells, and found that p38α deficiency causes these cells to hyperproliferate. Our studies indicate that both p38α and p38β are dispensable for T helper cell type 1 (Th1) differentiation but, by controlling interferon (IFN)γ and tumor necrosis factor (TNF)α production, are critical for normal Th1 effector function...
October 2017: Immunology and Cell Biology
https://www.readbyqxmd.com/read/28611473/apc-targeted-proinsulin-expression-inactivates-insulin-specific-memory-cd8-t-cells-in-nod-mice
#20
Peta Ls Reeves, Rajeev Rudraraju, Xiao Liu, F Susan Wong, Emma E Hamilton-Williams, Raymond J Steptoe
Type 1 diabetes (T1D) results from T-cell-mediated autoimmune destruction of pancreatic β cells. Effector T-cell responses emerge early in disease development and expand as disease progresses. Following β-cell destruction, a long-lived T-cell memory is generated that represents a barrier to islet transplantation and other cellular insulin-replacement therapies. Development of effective immunotherapies that control or ablate β-cell destructive effector and memory T-cell responses has the potential to prevent disease progression and recurrence...
October 2017: Immunology and Cell Biology
journal
journal
29544
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"