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Alzheimer Disease and Associated Disorders

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https://www.readbyqxmd.com/read/28796011/the-nature-and-natural-history-of-posterior-cortical-atrophy-syndrome-a-variant-of-early-onset-alzheimer-disease
#1
Peter K Panegyres, Judy Goh, Michael McCarthy, Andrew I Campbell
A prospective longitudinal evaluation of 12 patients over a 16-year interval using clinical neurological and imaging data to determine whether posterior cortical atrophy syndrome (PCA) related to early-onset Alzheimer disease (AD) and to examine its natural history. Our 12 patients had a median age of onset of 56 years (range, 48 to 63 y) and were followed for a median of 6 years (range, 3 to 9 y). Patients either presented with complex visual phenomena or developed them with time. Six patients underwent flurodeoxyglucose and Pittsburgh investigational compound B imaging which showed a mismatch between metabolic activity and amyloid deposition with reduced metabolism in parieto-occipital regions on flurodeoxyglucose positron emission tomography and diffuse neocortical uptake of amyloid without occipital predominance...
August 8, 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/28796010/the-report-of-p-val717phe-mutation-in-the-app-gene-in-a-hungarian-family-with-alzheimer-disease-a-phenomenological-study
#2
Dénes Zádori, Judit Füvesi, Erzsébet Timár, Emese Horváth, Renáta Bencsik, Noémi Szépfalusi, Anita Must, László Vécsei, Mária Judit Molnár, Péter Klivényi
No abstract text is available yet for this article.
August 8, 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/28796009/different-exposures-to-risk-factors-do-not-explain-the-inverse-relationship-of-occurrence-between-cancer-and-neurodegenerative-diseases-an-italian-nested-case-control-study
#3
Federica Prinelli, Fulvio Adorni, Maria Lea Correa Leite, Carla Pettenati, Antonio Russo, Simona Di Santo, Massimo Musicco
Several studies reported that cancer is less frequent in persons with Alzheimer's and Parkinson's Diseases (AD/PD) and vice-versa. We evaluated whether a different distribution of known nongenetic risk factors for cancer and AD/PD, might explain their inverse relationship of occurrence. We nested 2 case-control studies in a subsample of a large cohort of 1,000,000 resident in Lombardy Region in Italy (n=1515), followed-up for cancer and AD/PD occurrence since 1991 until 2012. Conditional logistic regression was performed to determine the odds ratios (OR) and 95% confidence intervals (CI) of AD/PD in subjects with and without cancer and the risk of cancer in those with and without AD/PD...
August 8, 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/28700383/the-use-of-the-clinical-dementia-rating-scale-sum-of-boxes-scores-in-detecting-and-staging-cognitive-impairment-dementia-in-brazilian-patients-with-low-educational-attainment
#4
Andrea P V Lima, Raphael Castilhos, Marcia L F Chaves
The aim of this study was to evaluate the Clinical Dementia Rating Scale sum of the boxes (CDR-SB) diagnostic validity in detecting and staging cognitive impairment/dementia in a sample of Brazilian patients with amnestic mild cognitive impairment (aMCI), Alzheimer disease (AD), and vascular dementia (VD), of low educational attainment. Data were obtained from the Dementia Clinic of Hospital de Clínicas de Porto Alegre database and included 407 participants (115 healthy elderly, 41 aMCI, 165 AD, and 86 VD)...
July 11, 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/28628488/falls-and-physical-activity-in-persons-with-mild-to-moderate-dementia-participating-in-an-intensive-motor-training-randomized-controlled-trial
#5
Tania Zieschang, Michael Schwenk, Clemens Becker, Lorenz Uhlmann, Peter Oster, Klaus Hauer
BACKGROUND: Physical activity is beneficial in people with dementia. As physical activity increases risk exposure for falls, safety concerns arise. Prior exercise trials in people with dementia have not measured physical activity. Falls in relation to exposure time rather than person-years as outcome measure has been promoted but not investigated in people with dementia. METHODS: Patients with mild to moderate dementia (n=110) were randomized to an intensive, progressive strength and functional training intervention or to a low-intensity group training for 12 weeks each...
June 16, 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/28582280/lorazepam-challenge-for-individuals-at-varying-genetic-risk-for-alzheimer-disease
#6
Cynthia M Stonnington, Brian Harel, Dona E C Locke, Joseph G Hentz, Nan Zhang, Paul Maruff, Richard J Caselli
INTRODUCTION: This study set out to clarify the differential acute cognitive impact of lorazepam based on varying genetic risk for Alzheimer disease. METHODS: Fifty-seven cognitively unimpaired individuals aged 51 to 88, genotyped according to apolipoprotein E (APOE) and translocase of outer mitochondrial membrane (40 homolog) poly-T lengths, completed cognitive testing before, 2.5 and 5 hours after receiving a 1 mg dose of lorazepam. RESULTS: Post-lorazepam, there were significant (P<0...
June 2, 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/28557843/increased-reporting-accuracy-of-alzheimer-disease-symptoms-in-caribbean-hispanic-informants
#7
Martina Azar, Carolyn Zhu, Brittany DeFeis, Yian Gu, Katherine Ornstein, Siobhan Lawless, Stephanie Cosentino
INTRODUCTION: Informant report of symptoms is essential for diagnosing and characterizing Alzheimer disease (AD). Differences in the perception and experience of dementia across ethnicities may influence informant report. Understanding such differences is critical given that among those with AD, Hispanics are disproportionately affected. METHODS: Cross-sectional analyses examined informant report of cognitive and functional symptoms in mild AD across white (n=107) and Caribbean Hispanic (n=71) informants...
May 26, 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/28486240/dependence-stage-and-pharmacoeconomic-outcomes-in-patients-with-alzheimer-disease
#8
Tzeyu L Michaud, Robin High, Mary E Charlton, Daniel L Murman
The level of assistance patients with Alzheimer disease (AD) require in their care may be an important predictor of resource use, costs of care, and quality of life. The Dependence Scale (DS), a measure of care-assistance required, was used to estimate costs of care and quality of life of patients with AD categorized into 6 dependence stages based upon the summated item scores of the DS. Data were derived from a 3-year, noninterventional study of 132 patients with probable AD (ages, 50 to 85 y) and caregiver dyads...
May 8, 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/28486239/pain-neuropsychiatric-symptoms-and-quality-of-life-of-nursing-home-residents-with-advanced-dementia-in-the-netherlands-a-cross-sectional-study
#9
Janine van Kooten, Johannes C van der Wouden, Sietske A M Sikkes, Martin Smalbrugge, Cees M P M Hertogh, Max L Stek
BACKGROUND: Many studies have investigated factors associated with quality of life (QoL) in nursing home residents with dementia. Both pain and neuropsychiatric symptoms (NPS) are clinically relevant and individually associated with a lower QoL; however, there are no studies that investigated pain and NPS together in relation to QoL. PURPOSE: In this study, we explored the relationship of pain and NPS with QoL in nursing home residents with dementia by investigating the association between pain concurrently with NPS, and QoL...
May 8, 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/28406845/heterogeneity-in-14-year-dementia-incidence-between-asian-american-subgroups
#10
Elizabeth R Mayeda, M Maria Glymour, Charles P Quesenberry, Rachel A Whitmer
BACKGROUND: Asian Americans are a rapidly growing and diverse population. Prior research on dementia among Asian Americans focused on Japanese Americans or Asian Americans overall, although marked differences in cardiometabolic conditions between subgroups have been documented. MATERIALS AND METHODS: We compared dementia incidence among 4 Asian American subgroups (n=8384 Chinese; n=4478 Japanese; n=6210 Filipino; n=197 South Asian) and whites (n=206,490) who were Kaiser Permanente Northern California members aged 64 years and above with no dementia diagnoses as of January 1, 2000...
April 12, 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/28538088/effects-of-the-insulin-sensitizer-metformin-in-alzheimer-disease-pilot-data-from-a-randomized-placebo-controlled-crossover-study
#11
Aaron M Koenig, Dawn Mechanic-Hamilton, Sharon X Xie, Martha F Combs, Anne R Cappola, Long Xie, John A Detre, David A Wolk, Steven E Arnold
Epidemiological studies have identified a robust association between type II diabetes mellitus and Alzheimer disease (AD), and neurobiological studies have suggested the presence of central nervous system insulin resistance in individuals with AD. Given this association, we hypothesized that the central nervous system-penetrant insulin-sensitizing medication metformin would be beneficial as a disease-modifying and/or symptomatic therapy for AD, and conducted a placebo-controlled crossover study of its effects on cerebrospinal fluid (CSF), neuroimaging, and cognitive biomarkers...
April 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/28538087/total-brain-and-hippocampal-volumes-and-cognition-in-older-american-indians-the-strong-heart-study
#12
Brenna Cholerton, Adam Omidpanah, Tara M Madhyastha, Thomas J Grabowski, Astrid M Suchy-Dicey, Dean K Shibata, Lonnie A Nelson, Steven P Verney, Barbara V Howard, William T Longstreth, Thomas J Montine, Dedra Buchwald
BACKGROUND: Estimates of hippocampal volume by magnetic resonance imaging have clinical and cognitive correlations and can assist in early Alzheimer disease diagnosis. However, little is known about the relationship between global or regional brain volumes and cognitive test performance in American Indians. MATERIALS AND METHODS: American Indian participants (N=698; median age, 72 y) recruited for the Cerebrovascular Disease and its Consequences in American Indians study, an ancillary study of the Strong Heart Study cohort, were enrolled...
April 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/28394771/tau-pet-binding-distinguishes-patients-with-early-stage-posterior-cortical-atrophy-from-amnestic-alzheimer-disease-dementia
#13
Gregory S Day, Brian A Gordon, Kelley Jackson, Jon J Christensen, Maria Rosana Ponisio, Yi Su, Beau M Ances, Tammie L S Benzinger, John C Morris
BACKGROUND: Flortaucipir (tau) positron emission tomography (PET) binding distinguishes individuals with clinically well-established posterior cortical atrophy (PCA) due to Alzheimer disease (AD) from cognitively normal (CN) controls. However, it is not known whether tau-PET binding patterns differentiate individuals with PCA from those with amnestic AD, particularly early in the symptomatic stages of disease. METHODS: Flortaucipir and florbetapir (β-amyloid) PET imaging were performed in individuals with early-stage PCA (N=5), amnestic AD dementia (N=22), and CN controls (N=47)...
April 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/28394770/the-biocard-index-a-summary-measure-to-predict-onset-of-mild-cognitive-impairment
#14
Ned Sacktor, Anja Soldan, Maura Grega, Leonie Farrington, Qing Cai, Mei-Cheng Wang, Rebecca F Gottesman, Raymond S Turner, Marilyn Albert
BACKGROUND: Changes in neuropsychological testing, neuroimaging, and cerebrospinal fluid may precede mild cognitive impairment (MCI). However, these markers are not routinely performed in outpatient clinical visits. OBJECTIVE: To evaluate whether a simple clinical index, consisting of questions given to patients and their informants, could predict the onset of symptoms of MCI among cognitively normal individuals. MATERIALS AND METHODS: Two hundred twenty-two participants in the BIOCARD study received a detailed history, physical examination, and neuropsychological testing annually...
April 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/28288010/functional-connectivity-is-reduced-in-early-stage-primary-progressive-aphasia-when-atrophy-is-not-prominent
#15
Borna Bonakdarpour, Emily J Rogalski, Allan Wang, Jaiashre Sridhar, M M Mesulam, Robert S Hurley
Primary progressive aphasia (PPA) is a clinical syndrome of language decline caused by neurodegenerative pathology. Although language impairments in PPA are typically localized via the morphometric assessment of atrophy, functional changes may accompany or even precede detectable structural alterations, in which case resting state functional connectivity (RSFC) could provide an alternative approach. The goal of this study was to determine whether language network RSFC is reduced in early-stage PPA when atrophy is not prominent...
April 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/28263191/coronary-artery-bypass-graft-surgery-and-dementia-risk-in-the-cardiovascular-health-study
#16
Elżbieta Kuźma, Jac Airdrie, Thomas J Littlejohns, Ilianna Lourida, Jo Thompson-Coon, Iain A Lang, Monica Scrobotovici, Evan L Thacker, Annette Fitzpatrick, Lewis H Kuller, Oscar L Lopez, William T Longstreth, Obioha C Ukoumunne, David J Llewellyn
INTRODUCTION: The association between history of coronary artery bypass graft surgery (CABG) and dementia risk remains unclear. METHODS: We conducted a prospective cohort analysis using data on 3155 elderly adults free from prevalent dementia from the US population-based Cardiovascular Health Study (CHS) with adjudicated incident all-cause dementia, Alzheimer disease (AD), vascular dementia (VaD), and mixed dementia. RESULTS: In the CHS, the hazard ratio (HR) for all-cause dementia was 1...
April 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/27875364/attenuation-of-choroidal-thickness-in-patients-with-alzheimer-disease-evidence-from-an-italian-prospective-study
#17
Alessandro Trebbastoni, Michela Marcelli, Fabiana Mallone, Fabrizia D'Antonio, Letizia Imbriano, Alessandra Campanelli, Carlo de Lena, Magda Gharbiya
INTRODUCTION: To compare the 12-month choroidal thickness (CT) change between Alzheimer disease (AD) patients and normal subjects. METHODS: In this prospective, observational study, 39 patients with a diagnosis of mild to moderate AD and 39 age-matched control subjects were included. All the subjects underwent neuropsychological (Mini Mental State Examination, Alzheimer disease Assessment Scale-Cognitive Subscale, and the Clinical Dementia Rating Scale) and ophthalmological evaluation, including spectral domain optical coherence tomography, at baseline and after 12 months...
April 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/27819846/validity-of-death-certificate-and-hospital-discharge-icd-codes-for-dementia-diagnosis-the-multi-ethnic-study-of-atherosclerosis
#18
Akira Fujiyoshi, David R Jacobs, Alvaro Alonso, José A Luchsinger, Stephen R Rapp, Daniel A Duprez
No abstract text is available yet for this article.
April 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/27819844/sociodemographic-characteristics-cognitive-function-and-health-related-quality-of-life-of-patients-referred-to-memory-assessment-services-in-england
#19
Min Hae Park, Sarah C Smith, Jenny Neuburger, Theopisti Chrysanthaki, A A Jolijn Hendriks, Nick Black
National policy in England is to encourage referral of people with suspected dementia to Memory Assessment Services (MAS). However, little is known about the characteristics of new referrals, which limits our capacity to evaluate these services. The objectives were to: describe the characteristics (age, sex, ethnicity, socioeconomic deprivation, and comorbidity) of referred patients, and examine the relationships between these characteristics and cognitive function (tertiles of Mini-Mental State Examination score) and health-related quality of life (HRQL) (DEMQOL, DEMQOL-Proxy)...
April 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/27819839/closing-in-is-related-to-daily-living-functioning-in-patients-with-mild-to-moderate-alzheimer-disease
#20
Natascia De Lucia, Dario Grossi, Luigi Trojano
No abstract text is available yet for this article.
April 2017: Alzheimer Disease and Associated Disorders
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