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Alzheimer Disease and Associated Disorders

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https://www.readbyqxmd.com/read/29461270/the-role-of-personality-in-a-regular-cognitive-monitoring-program
#1
Nasreen A Sadeq, Elise G Valdes, Aryn L Harrison Bush, Ross Andel
OBJECTIVES: This study examines the role of personality in cognitive performance, adherence, and satisfaction with regular cognitive self-monitoring. MATERIALS AND METHODS: One hundred fifty-seven cognitively healthy older adults, age 55+, completed the 44-item Big-Five Inventory and were subsequently engaged in online monthly cognitive monitoring using the Cogstate Brief Battery for up to 35 months (M=14 mo, SD=7 mo). The test measures speed and accuracy in reaction time, visual learning, and working memory tasks...
February 20, 2018: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/29438114/validity-and-reliability-of-the-frontotemporal-dementia-rating-scale-ftd-frs-for-the-progression-and-staging-of-dementia-in-brazilian-patients
#2
Thaís B Lima-Silva, Valéria S Bahia, Mário A Cecchini, Luciana Cassimiro, Henrique C Guimarães, Leandro B Gambogi, Paulo Caramelli, Márcio Balthazar, Benito Damasceno, Sônia M D Brucki, Leonardo C de Souza, Ricardo Nitrini, Eneida Mioshi, Mônica S Yassuda
INTRODUCTION: Few studies on instruments for staging frontotemporal dementia (FTD) have been conducted. OBJECTIVE: The objective of this study was to analyze the factor structure, internal consistency, reliability, and convergent validity of the Brazilian version of the Frontotemporal Dementia Rating Scale (FTD-FRS). METHODS: A total of 97 individuals aged 40 years and above with >2 years' education took part in the study, 31 patients diagnosed with behavioral variant FTD (bvFTD), 8 patients with primary progressive aphasia, 28 with Alzheimer disease, 8 with mild cognitive impairment, and a control group of 22 healthy subjects...
February 13, 2018: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/29389672/lacosamide-in-the-management-of-behavioral-symptoms-in-frontotemporal-dementia-a-2-case-report
#3
Francesco Di Lorenzo, Caterina Motta, Carlo Caltagirone, Giacomo Koch, Nicola Biagio Mercuri, Alessandro Martorana
No abstract text is available yet for this article.
January 31, 2018: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/29369829/primary-angiitis-of-the-central-nervous-system-mimicking-sporadic-creutzfeldt-jakob-disease-a-case-study
#4
Dian He, Gang Cai, Yan Li, Qi Liu, Kang Xiao, ChunTing Liu, Lan Chu, Shan Wu, Fang Liu, MingYao You, WeiJia Jiang
No abstract text is available yet for this article.
January 29, 2018: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/29351092/political-ideology-confidence-in-science-and-participation-in-alzheimer-disease-research-studies
#5
Matthew Gabel, Jonathan Gooblar, Catherine M Roe, Natalie J Selsor, John C Morris
BACKGROUND: Americans' confidence in science varies based on their political ideology. This ideological divide has potentially important effects on citizens' engagement with and participation in clinical studies of Alzheimer disease (AD). METHODS: A probability sample of 1583 Americans was surveyed about their willingness to participate in longitudinal AD research and about their political attitudes. These survey results were compared with a survey of 382 participants in a longitudinal AD study at the Knight Alzheimer Disease Research Center...
January 18, 2018: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/29351091/circadian-rhythms-disturbances-in-alzheimer-disease-current-concepts-diagnosis-and-management
#6
Ángela Milán-Tomás, Colin M Shapiro
The purpose of this review is to provide an overview of the research regarding circadian rhythms in Alzheimer disease (AD). Furthermore, this paper explores the role of melatonin in the pathogenesis of AD and the limitation of trials addressing circadian rhythms disturbances in the AD population. A literature search using Medline with PubMed and Embase was carried out identifying papers focusing on circadian rhythms in AD. Sleep disorders and especially circadian rhythm disturbances are very common in the elderly population but definitely more pronounced in patients with AD...
January 18, 2018: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/29334499/cognitive-function-and-its-risk-factors-among-older-us-adults-living-at-home
#7
William Dale, Ashwin A Kotwal, Joseph W Shega, L Philip Schumm, David W Kern, Jayant M Pinto, Kelly M Pudelek, Linda J Waite, Martha K McClintock
BACKGROUND: The Montreal Cognitive Assessment (MoCA) has not been administered to a representative national sample, precluding comparison of patient scores to the general population and for risk factor identification. METHODS: A validated survey-based adaptation of the MoCA (MoCA-SA) was administered to a probability sample of home-dwelling US adults aged 62 to 90, using the National Social Life, Health, and Aging Project (n=3129), yielding estimates of prevalence in the United States...
January 12, 2018: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/29334498/evidence-based-interpretation-of-amyloid-%C3%AE-pet-results-a-clinician-s-tool
#8
David Bergeron, Rik Ossenkoppele, Robert Jr Laforce
BACKGROUND: Amyloid-β positron emission tomography (PET) allows for in vivo detection of fibrillar amyloid plaques, a pathologic hallmark of Alzheimer's disease (AD). However, amyloid-β PET interpretation is limited by the imperfect correlation between PET and autopsy, and the fact that it is positive in about 20% to 30% of cognitively normal individuals and non-AD dementias, especially when older or carrying the ε4 allele of apolipoprotein E (ApoE4). When facing a positive amyloid PET, clinicians have to evaluate the probability of a pathologic false positive as well as the probability of amyloid positivity being age-related, comorbid to a primary non-AD dementia (clinicopathologic false positive)...
January 12, 2018: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/29319603/population-neuroscience-dementia-epidemiology-serving-precision-medicine-and-population-health
#9
Mary Ganguli, Emiliano Albanese, Sudha Seshadri, David A Bennett, Constantine Lyketsos, Walter A Kukull, Ingmar Skoog, Hugh C Hendrie
Over recent decades, epidemiology has made significant contributions to our understanding of dementia, translating scientific discoveries into population health. Here, we propose reframing dementia epidemiology as "population neuroscience," blending techniques and models from contemporary neuroscience with those of epidemiology and biostatistics. On the basis of emerging evidence and newer paradigms and methods, population neuroscience will minimize the bias typical of traditional clinical research, identify the relatively homogenous subgroups that comprise the general population, and investigate broader and denser phenotypes of dementia and cognitive impairment...
January 9, 2018: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/29319602/an-interactional-profile-to-assist-the-differential-diagnosis-of-neurodegenerative-and-functional-memory-disorders
#10
Markus Reuber, Daniel J Blackburn, Chris Elsey, Sarah Wakefield, Kerry A Ardern, Kirsty Harkness, Annalena Venneri, Danielle Jones, Chloe Shaw, Paul Drew
OBJECTIVE: Specialist services for dementia are seeing an increasing number of patients. We investigated whether interactional and linguistic features in the communication behavior of patients with memory problems could help distinguish between those with problems secondary to neurological disorders (ND) and those with functional memory disorder (FMD). METHODS: In part 1 of this study, a diagnostic scoring aid (DSA) was developed encouraging linguists to provide quantitative ratings for 14 interactional features...
January 9, 2018: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/29319601/the-moca-memory-index-score-an-efficient-alternative-to-paragraph-recall-for-the-detection-of-amnestic-mild-cognitive-impairment
#11
Antarpreet Kaur, Steven D Edland, Guerry M Peavy
OBJECTIVE: To compare ability of 2 measures of delayed memory (word list, story paragraph) to discriminate Normal Control (NC) subjects from those with amnestic mild cognitive impairment (aMCI). METHODS: Demographic, neuropsychological, and diagnostic data contributed by 34 Alzheimer's Disease Centers to the National Alzheimer's Coordinating Center characterized 2717 individuals with a diagnosis of either NC (n=2205) or aMCI (n=512). The Montreal Cognitive Assessment-Memory Index Score (MoCA-MIS) assessed delayed word recall, and the Craft Story 21, delayed story recall...
January 9, 2018: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/29283927/are-informal-caregivers-of-persons-with-dementia-open-to-extending-medical-aid-in-dying-to-incompetent-patients-findings-from-a-survey-conducted-in-quebec-canada
#12
Gina Bravo, Claudie Rodrigue, Marcel Arcand, Jocelyn Downie, Marie-France Dubois, Sharon Kaasalainen, Cees M Hertogh, Sophie Pautex, Lieve Van den Block
Euthanasia is a controversial and complex issue, especially when involving incompetent patients. On December 10, 2015, Quebec became the first Canadian province to give access to medical aid in dying (MAiD) (ie, euthanasia performed by a physician) to competent patients who satisfy strictly defined criteria. Less than 2 years later, Quebec is considering extending MAiD to incompetent patients who made an advance request. With the objective of contributing scientific data to current societal debates, we conducted a survey among 471 informal caregivers of persons with dementia, reached through Alzheimer Societies...
December 27, 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/29278559/brain-volumes-and-longitudinal-cognitive-change-a-population-based-study
#13
Deepti Vibha, Henning Tiemeier, Saira S Mirza, Hieab H H Adams, Wiro J Niessen, Albert Hofman, Kameshwar Prasad, Aad van der Lugt, Meike W Vernooij, Mohammad A Ikram
OBJECTIVE: To investigate the association of brain volumes, white matter lesion (WML) volumes, and lacunes, with cognitive decline in a population-based cohort of nondemented persons. METHODS: Within the Rotterdam Study, 3624 participants underwent brain magnetic resonance imaging. Cognition was evaluated at baseline (2005 to 2009) and at the follow-up visit (2011 to 2013). We used a test battery that tapped into domains of executive function, information processing speed, motor speed, and memory...
December 27, 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/29278558/autopsy-of-an-elderly-man-with-incidentally-diagnosed-tdp-43-proteinopathy
#14
Yukiko Hata, Koji Yoshida, Naoki Nishida
No abstract text is available yet for this article.
December 22, 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/29278557/discrepancies-between-alzheimer-s-disease-patients-and-caregivers-ratings-about-patients-quality-of-life-a-1-year-observation-study-in-brazil
#15
Maria F B Sousa, Raquel L Santos, Pedro Simões, Josep L Conde-Sala, Marcia C N Dourado
OBJECTIVES: We investigated the factors associated with discrepancies between patients' and caregivers' ratings about patients' general quality of life (QoL) and about the domains of Quality of Life in Alzheimer's disease (QoL-AD) Scale at baseline and 12 months. METHODS: This was a longitudinal study that comprised 114 outpatients with AD and their caregivers. Patients were assessed with the QoL-AD, Mini-mental State Examination, Assessment Scale of Psychosocial Impact of the Diagnosis of Dementia, Cornell Scale for Depression, Functional Activities Questionnaire, and Neuropsychiatric Inventory, and Clinical Dementia Rating Scale...
December 22, 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/29261520/inferior-parietal-cortex-hypoperfusion-is-the-most-specific-imaging-marker-for-ad-patients-with-positive-csf-biomarker-assays-in-a-memory-clinic-in-france
#16
Daniela Andriuta, Véronique Moullart, Susanna Schraen, Agnes Devendeville, Marc-Etienne Meyer, Olivier Godefroy
The diagnostic accuracy of hexamethylpropyleneamine oxime (HMPAo) single-photon emission computed tomography (SPECT) in Alzheimer disease (AD) remains undetermined in a "real-life" clinical population. The objective was to determine the HMPAo SPECT hypoperfusion pattern in cognitively impaired patients with positive CSF AD biomarker and to evaluate its diagnostic accuracy. This study included 120 patients referred to a university memory clinic assessed using HMPAo SPECT, MRI, and CSF biomarkers. Three biomarker signatures suggestive of AD were analyzed (1, Aß1-42; 2, Aß1-42+t-tau and/or p-tau; 3, Aß1-42/p-tau)...
December 19, 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/29261519/diabetic-retinopathy-and-dementia-in-type-1-diabetes
#17
Liora G Rodill, Lieza G Exalto, Paola Gilsanz, Geert Jan Biessels, Charles P Quesenberry, Rachel A Whitmer
OBJECTIVE: Retinopathy impacts over one-third of those with diabetes mellitus and is associated with impaired cognitive performance and cerebrovascular lesions in middle-aged adults with type 1 diabetes. However, the association between diabetic retinopathy (DR) and risk of dementia in type 1 diabetes is unknown. We investigated the association between DR and incident dementia in a large, elderly population with type 1 diabetes. METHODS: A cohort of 3742 patients with type 1 diabetes aged 50 years and above was followed from January 1, 1996 to September 30, 2015 for incident dementia...
December 19, 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/29240562/occurrence-of-impaired-physical-performance-in-memory-clinic-patients-with-cerebral-small-vessel-disease
#18
Jurre H Verwer, Geert-Jan Biessels, Rutger Heinen, Lieza G Exalto, Marielle H Emmelot-Vonk, Huiberdina L Koek
Cerebral small vessel disease (CSVD) occurs often in memory clinic patients. Apart from cognitive deficits, these patients can express physical decline, which predicts adverse health outcomes. In this study, we investigated the cooccurrence of clinically relevant impairments in physical performance and CSVD in memory clinic patients. We included 131 patients with vascular brain injury, mild cognitive impairment or Alzheimer disease with available 3T MRI and physical performance scores. CSVD was visually rated according to 3 subtypes and as a total burden score, composed of the presence of white matter hyperintensities (WMH), lacunar infarcts (LI), and cerebral microbleeds (MB)...
December 13, 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/29240561/version-3-of-the-alzheimer-disease-centers-neuropsychological-test-battery-in-the-uniform-data-set-uds
#19
Sandra Weintraub, Lilah Besser, Hiroko H Dodge, Merilee Teylan, Steven Ferris, Felicia C Goldstein, Bruno Giordani, Joel Kramer, David Loewenstein, Dan Marson, Dan Mungas, David Salmon, Kathleen Welsh-Bohmer, Xiao-Hua Zhou, Steven D Shirk, Alireza Atri, Walter A Kukull, Creighton Phelps, John C Morris
INTRODUCTION: The neuropsychological battery of the Uniform Data Set (UDSNB) was implemented in 2005 by the National Institute on Aging (NIA) Alzheimer Disease Centers program to measure cognitive performance in dementia and mild cognitive impairment due to Alzheimer Disease. This paper describes a revision, the UDSNB 3.0. METHODS: The Neuropsychology Work Group of the NIA Clinical Task Force recommended revisions through a process of due diligence to address shortcomings of the original battery...
December 13, 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/29227306/big-data-analytical-approaches-to-the-nacc-dataset-aiding-preclinical-trial-enrichment
#20
Ming Lin, Pinghua Gong, Tao Yang, Jieping Ye, Roger L Albin, Hiroko H Dodge
BACKGROUND: Clinical trials increasingly aim to retard disease progression during presymptomatic phases of Mild Cognitive Impairment (MCI) and thus recruiting study participants at high risk for developing MCI is critical for cost-effective prevention trials. However, accurately identifying those who are destined to develop MCI is difficult. Collecting biomarkers is often expensive. METHODS: We used only noninvasive clinical variables collected in the National Alzheimer's Coordinating Center (NACC) Uniform Data Sets version 2...
December 7, 2017: Alzheimer Disease and Associated Disorders
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