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Alzheimer Disease and Associated Disorders

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https://www.readbyqxmd.com/read/27875364/attenuation-of-choroidal-thickness-in-patients-with-alzheimer-disease-evidence-from-an-italian-prospective-study
#1
Alessandro Trebbastoni, Michela Marcelli, Fabiana Mallone, Fabrizia D'Antonio, Letizia Imbriano, Alessandra Campanelli, Carlo de Lena, Magda Gharbiya
INTRODUCTION: To compare the 12-month choroidal thickness (CT) change between Alzheimer disease (AD) patients and normal subjects. METHODS: In this prospective, observational study, 39 patients with a diagnosis of mild to moderate AD and 39 age-matched control subjects were included. All the subjects underwent neuropsychological (Mini Mental State Examination, Alzheimer disease Assessment Scale-Cognitive Subscale, and the Clinical Dementia Rating Scale) and ophthalmological evaluation, including spectral domain optical coherence tomography, at baseline and after 12 months...
November 21, 2016: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/27849642/sarcopenia-is-associated-with-impairment-of-activities-of-daily-living-in-japanese-patients-with-early-stage-alzheimer-disease
#2
Taiki Sugimoto, Rei Ono, Shunsuke Murata, Naoki Saji, Yasumoto Matsui, Shumpei Niida, Kenji Toba, Takashi Sakurai
No abstract text is available yet for this article.
November 15, 2016: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/27849641/genetic-comparison-of-symptomatic-and-asymptomatic-persons-with-alzheimer-disease-neuropathology
#3
Sarah E Monsell, Charles Mock, David W Fardo, Sarah Bertelsen, Nigel J Cairns, Catherine M Roe, Sally R Ellingson, John C Morris, Alison M Goate, Walter A Kukull
OBJECTIVE: The objective was to determine whether symptomatic and asymptomatic persons with Alzheimer's disease (AD) neuropathology have different allele counts for single-nucleotide polymorphisms that have been associated with clinical late-onset AD. METHODS: Data came from the National Alzheimer's Coordinating Center Uniform Data Set and Neuropathology Data Set, and the Alzheimer's Disease Genetics Consortium (ADGC). Participants had low to high AD neuropathologic change...
November 15, 2016: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/27849640/rapidly-progressive-dementia-prevalence-and-causes-in-a-neurologic-unit-of-a-tertiary-hospital-in-brazil
#4
Adalberto Studart Neto, Herval R Soares Neto, Mateus M Simabukuro, Davi J F Solla, Márcia R R Gonçalves, Ida Fortini, Luiz H M Castro, Ricardo Nitrini
BACKGROUND: Rapidly progressive dementia (RPD) is usually associated with Creutzfeldt-Jakob disease, a fatal condition. Current advances in the understanding of immune-mediated diseases allow the diagnosis of previously unrecognized treatable RPDs. OBJECTIVE OF THE STUDY: The objective of the study was to describe the prevalence and causes of RPD in a neurology service, identifying potentially reversible causes. METHODS: We carried out a cross-sectional evaluation of all patients admitted to the neurology unit of a tertiary hospital in Brazil between March 2012 and February 2015...
November 15, 2016: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/27849639/wecareadvisor%C3%A2-the-development-of-a-caregiver-focused-web-based-program-to-assess-and-manage-behavioral-and-psychological-symptoms-of-dementia
#5
Helen C Kales, Laura N Gitlin, Barbara Stanislawski, Katherine Marx, Molly Turnwald, Daphne C Watkins, Constantine G Lyketsos
BACKGROUND/OBJECTIVES: Behavioral and psychological symptoms of dementia (BPSD) are nearly universal in dementia and associated with multiple negative outcomes. Current real-world management is largely pharmacologic, despite poor risk/benefit. The WeCareAdvisor was designed to enable family caregivers to assess, manage, and track BPSD using nonpharmacologic strategies. DESIGN: In-depth qualitative data were collected from family caregivers of people with dementia to inform: (1) style of approach and "look and feel" of the tool, and (2) the types of psychoeducation most needed by caregivers...
November 15, 2016: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/27849637/pneumonia-intake-problems-and-survival-among-nursing-home-residents-with-variable-stages-of-dementia-in-the-netherlands-results-from-a-prospective-observational-study
#6
Simone A Hendriks, Martin Smalbrugge, Arianne B van Gageldonk-Lafeber, Francisca Galindo-Garre, Maarten Schipper, Cees M P M Hertogh, Jenny T van der Steen
OBJECTIVES: We explored how pneumonia and intake problems affect survival in nursing home residents in variable stages of dementia. METHODS: In a longitudinal observational study (372 residents) with up to 3.5 years of follow-up, we examined relationships between dementia severity, the development of pneumonia, intake problems, and mortality using joint modeling, Cox models, and mediation analyses. Dementia severity was measured semiannually with the Bedford Alzheimer Nursing Severity-Scale (BANS-S)...
November 15, 2016: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/27819846/validity-of-death-certificate-and-hospital-discharge-icd-codes-for-dementia-diagnosis-the-multi-ethnic-study-of-atherosclerosis
#7
Akira Fujiyoshi, David R Jacobs, Alvaro Alonso, José A Luchsinger, Stephen R Rapp, Daniel A Duprez
No abstract text is available yet for this article.
November 4, 2016: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/27819845/the-potential-value-of-%C3%AE-amyloid-imaging-for-the-diagnosis-and-management-of-dementia-a-survey-of-clinicians
#8
Yue Zhong, Jason Karlawish, Meridith K Johnson, Peter J Neumann, Joshua T Cohen
We assessed the potential influence of β-amyloid imaging on clinician diagnoses and management of patients with memory loss. We surveyed 315 clinicians, assigning each a vignette describing a hypothetical patient with symptoms of unexplained mild cognitive impairment, possible Alzheimer disease (AD), or young-onset dementia. Vignettes reported "positive," "negative," or no β-amyloid imaging information. We assessed imaging's influence on diagnosis (AD contribution to symptoms), diagnostic confidence, and patient management...
November 4, 2016: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/27819844/sociodemographic-characteristics-cognitive-function-and-health-related-quality-of-life-of-patients-referred-to-memory-assessment-services-in-england
#9
Min Hae Park, Sarah C Smith, Jenny Neuburger, Theopisti Chrysanthaki, A A Jolijn Hendriks, Nick Black
National policy in England is to encourage referral of people with suspected dementia to Memory Assessment Services (MAS). However, little is known about the characteristics of new referrals, which limits our capacity to evaluate these services. The objectives were to: describe the characteristics (age, sex, ethnicity, socioeconomic deprivation, and comorbidity) of referred patients, and examine the relationships between these characteristics and cognitive function (tertiles of Mini-Mental State Examination score) and health-related quality of life (HRQL) (DEMQOL, DEMQOL-Proxy)...
November 4, 2016: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/27819843/impact-of-functional-deficits-in-instrumental-activities-of-daily-living-in-mild-cognitive-impairment-a-clinical-algorithm-to-predict-progression-to-dementia
#10
Davangere P Devanand, Xinhua Liu, Patrick J Brown
BACKGROUND: The utility of functional deficits in patients with mild cognitive impairment is not established. MATERIALS AND METHODS: In 3886 individuals with mild cognitive impairment evaluated and followed at 34 National Alzheimer Coordinating Center sites, informant-reported Pfeffer Functional Activities Questionnaire (FAQ) items associated with progression to dementia were derived in a training set (n=1943) and tested in the validation set (n=1943). RESULTS: In the training set, the optimal combination comprised 6 FAQ items (FAQ6): difficulties with finances (2 items), remembering events/appointments, playing games of skill, current events, and travel...
November 4, 2016: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/27819842/low-dose-lithium-treatment-for-agitation-and-psychosis-in-alzheimer-disease-and-frontotemporal-dementia-a-case-series
#11
Davangere P Devanand, Gregory H Pelton, Kristina D'Antonio, Jesse G Strickler, William C Kreisl, James Noble, Karen Marder, Anne Skomorowsky, Edward D Huey
No abstract text is available yet for this article.
November 4, 2016: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/27819840/repressive-coping-does-not-contribute-to-anosognosia-in-first-diagnosis-patients-with-alzheimer-disease
#12
Sandra Verhülsdonk, Christian Lange-Asschenfeldt, Barbara Höft, Holger Schwender, Tillmann Supprian, Florence Hellen, Elke Kalbe
Anosognosia is common in patients with Alzheimer disease (AD) even in early stages. Although neural correlates and the impact of cognitive dysfunctions have been described, possible psychodynamic processes such as a repressive coping style as described in other illnesses, have not been examined. Our study aimed to examine possible psychological influence factors on illness perception embracing a repressive coping style and cognitive functions in AD patients in the diagnostic process. Fifty-four subjects with mild AD diagnosed in our memory clinic were enrolled...
November 4, 2016: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/27819839/closing-in-is-related-to-daily-living-functioning-in-patients-with-mild-to-moderate-alzheimer-disease
#13
Natascia De Lucia, Dario Grossi, Luigi Trojano
No abstract text is available yet for this article.
November 4, 2016: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/27779492/willingness-to-be-a-brain-donor-a-survey-of-research-volunteers-from-4-racial-ethnic-groups
#14
Linda Boise, Ladson Hinton, Howard J Rosen, Mary C Ruhl, Hiroko Dodge, Nora Mattek, Marilyn Albert, Andrea Denny, Joshua D Grill, Travonia Hughes, Jennifer H Lingler, Darby Morhardt, Francine Parfitt, Susan Peterson-Hazan, Viorela Pop, Tara Rose, Raj C Shah
INTRODUCTION: Racial and ethnic groups are under-represented among research subjects who assent to brain donation in Alzheimer disease research studies. There has been little research on this important topic. Although there are some studies that have investigated the barriers to brain donation among African American study volunteers, there is no known research on the factors that influence whether or not Asians or Latinos are willing to donate their brains for research. METHODS: African American, Caucasian, Asian, and Latino research volunteers were surveyed at 15 Alzheimer Disease Centers to identify predictors of willingness to assent to brain donation...
October 24, 2016: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/27755004/diabetes-hemoglobin-a1c-and-regional-alzheimer-disease-and-infarct-pathology
#15
Jeremy J Pruzin, Julie A Schneider, Ana W Capuano, Sue E Leurgans, Lisa L Barnes, Rexford S Ahima, Steven E Arnold, David A Bennett, Zoe Arvanitakis
We examined the relationship of diabetes and hemoglobin A1C (A1C) to 2 common causes of dementia. The study included 1228 subjects who underwent annual clinical evaluations and a brain autopsy at death, as part of a Rush longitudinal cohort study of aging. A total of 433 subjects had A1C data available. Neuropathologic evaluations documented the size and location of infarcts. Modified silver stain-based Alzheimer disease (AD) measures included global and regional scores. We used regression analyses to examine associations of diabetes and A1C with overall and regional neuropathology...
October 17, 2016: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/27755003/modeling-alzheimer-s-disease-through-functional-independence-and-participation
#16
Chiara Zucchella, Michelangelo Bartolo, Sara Bernini, Marta Picascia, Paola Malinverni, Elena Sinforiani
INTRODUCTION: The relationship between cognitive and functional impairment in Alzheimer's Disease (AD) at the earliest stages of the disease is not well characterized. This study aimed at investigating such relationships along AD evolution by means of the Disability Assessment for Dementia (DAD). METHODS: Consecutive pairs of AD outpatients and their primary informal caregivers were enrolled. Patients were evaluated by means of the Mini Mental State Examination and neuropsychological tests...
October 17, 2016: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/27680780/cholinergic-changes-in-aging-and-alzheimer-disease-an-18f-f-a-85380-exploratory-pet-study
#17
Julien Lagarde, Marie Sarazin, Valérie Chauviré, Bruno Stankoff, Aurélie Kas, Lucette Lacomblez, Marie-Anne Peyronneau, Michel Bottlaender
The central cholinergic system undergoes changes during the physiological process of aging and the pathologic process of Alzheimer disease (AD). We aimed to analyze the impairment of cholinergic pathways by positron emission tomography using the [F]-F-A-85380 (FA85) tracer, which has a high affinity for nicotinic acetylcholine receptors (nAChRs). Aging was assessed by comparing young (n=10) and elderly (n=4) healthy subjects, and the pathologic process of AD was assessed by comparing elderly controls and age-matched AD patients (n=8)...
September 27, 2016: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/27861179/cognitive-impairment-and-dementia-in-older-adults-with-chronic-kidney-disease-a-review
#18
Andrea R Zammit, Mindy J Katz, Markus Bitzer, Richard B Lipton
Individuals with chronic kidney disease (CKD), especially older adults, are at more risk of experiencing cognitive impairment, possibly leading to mild cognitive impairment and/or dementia. Studies report associations between CKD and cognitive impairment; although unclear, there seems to be a graded association between stage of CKD and affected cognitive domains, with executive function being affected earlier in the process than episodic memory and global ability. In CKD, dysexecutive mild cognitive impairment and vascular dementia are also more prominent than other subtypes...
October 2016: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/27849638/role-of-apoe-%C3%AE%C2%B54-allele-and-incident-stroke-on-cognitive-decline-and-mortality
#19
Kumar B Rajan, Neelum T Aggarwal, Julie A Schneider, Robert S Wilson, Susan A Everson-Rose, Denis A Evans
BACKGROUND: The apolipoprotein E (APOE) ε4 allele and stroke increase the risk of cognitive decline. However, the association of the APOE ε4 allele before and after stroke is not well understood. METHODS: Using a prospective sample of 3444 (66% African Americans, 61% females, mean age=71.9 y) participants, we examined cognitive decline relative to stroke among those with and without the APOE ε4 allele. RESULTS: In our sample, 505 (15%) had incident stroke...
October 2016: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/27819841/recruiting-us-chinese-elders-into-clinical-research-for-dementia
#20
Clara Li, Judith Neugroschl, Mari Umpierre, Jane Martin, QiYing Huang, Xiaoyi Zeng, Dongming Cai, Mary Sano
PURPOSE: This study described and evaluated the rapid recruitment of elderly Chinese into clinical research at the Mount Sinai Alzheimer's Disease Research Center (MSADRC). DESIGN AND METHODS: Methods of publicizing the study included lectures to local senior centers/churches and publications in local Chinese newspapers. The amount of time and success of these methods were evaluated. A "go to them" model of evaluation was used to enable participants to complete the study visit at locations where they were comfortable...
October 2016: Alzheimer Disease and Associated Disorders
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