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Alzheimer Disease and Associated Disorders

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https://www.readbyqxmd.com/read/29240562/occurrence-of-impaired-physical-performance-in-memory-clinic-patients-with-cerebral-small-vessel-disease
#1
Jurre H Verwer, Geert-Jan Biessels, Rutger Heinen, Lieza G Exalto, Marielle H Emmelot-Vonk, Huiberdina L Koek
Cerebral small vessel disease (CSVD) occurs often in memory clinic patients. Apart from cognitive deficits, these patients can express physical decline, which predicts adverse health outcomes. In this study, we investigated the cooccurrence of clinically relevant impairments in physical performance and CSVD in memory clinic patients. We included 131 patients with vascular brain injury, mild cognitive impairment or Alzheimer disease with available 3T MRI and physical performance scores. CSVD was visually rated according to 3 subtypes and as a total burden score, composed of the presence of white matter hyperintensities (WMH), lacunar infarcts (LI), and cerebral microbleeds (MB)...
December 13, 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/29240561/version-3-of-the-alzheimer-disease-centers-neuropsychological-test-battery-in-the-uniform-data-set-uds
#2
Sandra Weintraub, Lilah Besser, Hiroko H Dodge, Merilee Teylan, Steven Ferris, Felicia C Goldstein, Bruno Giordani, Joel Kramer, David Loewenstein, Dan Marson, Dan Mungas, David Salmon, Kathleen Welsh-Bohmer, Xiao-Hua Zhou, Steven D Shirk, Alireza Atri, Walter A Kukull, Creighton Phelps, John C Morris
INTRODUCTION: The neuropsychological battery of the Uniform Data Set (UDSNB) was implemented in 2005 by the National Institute on Aging (NIA) Alzheimer Disease Centers program to measure cognitive performance in dementia and mild cognitive impairment due to Alzheimer Disease. This paper describes a revision, the UDSNB 3.0. METHODS: The Neuropsychology Work Group of the NIA Clinical Task Force recommended revisions through a process of due diligence to address shortcomings of the original battery...
December 13, 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/29227306/big-data-analytical-approaches-to-the-nacc-dataset-aiding-preclinical-trial-enrichment
#3
Ming Lin, Pinghua Gong, Tao Yang, Jieping Ye, Roger L Albin, Hiroko H Dodge
BACKGROUND: Clinical trials increasingly aim to retard disease progression during presymptomatic phases of Mild Cognitive Impairment (MCI) and thus recruiting study participants at high risk for developing MCI is critical for cost-effective prevention trials. However, accurately identifying those who are destined to develop MCI is difficult. Collecting biomarkers is often expensive. METHODS: We used only noninvasive clinical variables collected in the National Alzheimer's Coordinating Center (NACC) Uniform Data Sets version 2...
December 7, 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/29200011/coronal-ct-is-comparable-to-mr-imaging-in-aiding-diagnosis-of-dementia-in-a-memory-clinic-in-singapore
#4
Sasinthiran Thiagarajan, Muhammad A Shaik, Narayanaswamy Venketasubramanian, Eric Y S Ting, Saima Hilal, Christopher Chen
PURPOSE: The present study investigated (a) the agreement between computerized tomography (CT) and 3 T magnetic resonance imaging (MRI) in the visual grading of medial temporal atrophy (MTA); and (b) whether MTA on CT differentiated patients with dementia from no dementia in memory clinics. MATERIALS AND METHODS: Data were obtained from patients who underwent CT scans at the National University Hospital of Singapore, and from a subsample who subsequently underwent 3 T MRI scans in a research study...
December 1, 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/29189303/biomarkers-of-cognitive-impairment-brain-cortical-thickness-volumetrics-and-cerebrospinal-fluid
#5
Ladan Ghazi-Saidi, Ryan R Walsh, Guogen Shan, Sarah J Banks
No abstract text is available yet for this article.
November 17, 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/29189302/sex-differences-in-neuropsychological-test-performance-in-alzheimer-s-disease-and-the-influence-of-the-apoe-genotype
#6
Maria Tensil, Johannes B Hessler, Maria Gutsmiedl, Lina Riedl, Timo Grimmer, Janine Diehl-Schmid
BACKGROUND: Only few studies exist reporting sex differences in the Alzheimer disease (AD) patients regarding cognitive profile, brain damage, and risk factors. The present study investigated the influence of sex in combination with the Alzheimer risk allele, ε4-allele of apolipoprotein E, on cognitive performance. MATERIALS AND METHODS: We examined the effect of sex and ApoE genotype on a range of neuropsychological markers from the German version of the Consortium to Establish a Registry in Alzheimer's Disease Neuropsychological Battery in a monocentric study of 399 AD patients...
November 17, 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/29189301/assessing-fitness-to-drive-in-patients-with-different-types-of-dementia
#7
Dafne Piersma, Anselm B M Fuermaier, Dick De Waard, Ragnhild J Davidse, Jolieke De Groot, Michelle J A Doumen, Ruud A Bredewoud, René Claesen, Afina W Lemstra, Philip Scheltens, Annemiek Vermeeren, Rudolf Ponds, Frans Verhey, Peter P De Deyn, Wiebo H Brouwer, Oliver Tucha
Dementia is a risk factor for unsafe driving. Therefore, an assessment strategy has recently been developed for the prediction of fitness to drive in patients with the Alzheimer disease (AD). The aim of this study was to investigate whether this strategy is also predictive of fitness to drive in patients with non-AD dementia, that is, vascular dementia, frontotemporal dementia, and dementia with Lewy bodies. Predictors were derived from 3 types of assessment: clinical interviews, neuropsychological tests, and driving simulator rides...
November 17, 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/29189300/elevated-als-biomarker-levels-in-csf-of-a-ftd-patient-at-the-presymptomatic-stage-of-als
#8
Emmanuel Cognat, Maxim De Schaepdryver, Jacques Hugon, Koen Poesen, Claire Paquet
No abstract text is available yet for this article.
November 17, 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/29140859/patient-and-caregiver-assessment-of-the-benefits-from-the-clinical-use-of-amyloid-pet-imaging
#9
Rafid Mustafa, Jared R Brosch, Gil D Rabinovici, Bradford C Dickerson, Maria C Carrillo, Bradley S Glazier, Sujuan Gao, Martha Tierney, Keith N Fargo, Mary G Austrom, Susan De Santi, David G Clark, Liana G Apostolova
INTRODUCTION: Few studies to date have explored patient and caregiver views on the clinical use of amyloid positron emission tomography (PET). METHODS: A 7-item questionnaire assessing patient and caregiver views (510 total respondents) toward amyloid PET imaging was advertised broadly through alz.org/trialmatch. RESULTS: We received 510 unique responses from 48 US states, 2 Canadian provinces, the Dominican Republic, and Greece. Both patients and caregivers indicated that they would want to receive amyloid imaging if offered the opportunity...
November 14, 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/29140858/computerized-cognitive-testing-in-primary-care-a-qualitative-study
#10
Geneva Millett, Gary Naglie, Ross Upshur, Liisa Jaakkimainen, Jocelyn Charles, Mary C Tierney
Computerized cognitive assessment tools may facilitate early identification of dementia in the primary care setting. We investigated primary care physicians' (PCPs') views on advantages and disadvantages of computerized testing based on their experience with the Computer Assessment of Mild Cognitive Impairment (CAMCI). Over a 2-month period, 259 patients, 65 years and older, from the family practice of 13 PCPs completed the CAMCI. Twelve PCPs participated in an individual interview. Generally, PCPs felt that the relationship between them and their patients helped facilitate cognitive testing; however, they thought available paper tests were time consuming and not sufficiently informative...
November 14, 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/29140857/that-s-inappropriate-social-norms-in-an-older-population-based-cohort
#11
Mary Ganguli, Zhaowen Sun, Eric McDade, Beth Snitz, Tiffany Hughes, Erin Jacobsen, Chung-Chou H Chang
BACKGROUND: Social cognition is not routinely assessed in older adults. We report population-based normative data on the Social Norms Questionnaire (SNQ22) which asks individuals about the appropriateness of specific behaviors in hypothetical scenarios, errors being related either to breaking with norms or to over-adhering to perceived norms. Total SNQ scores represent the number of correct responses while subscale scores are error totals. METHODS: We administered the SNQ22 to 744 adults aged 65+ within a population-based study, and examined the distribution of scores by demographics, other cognitive measures, and Clinical Dementia Rating (CDR)...
November 14, 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/29116943/the-pparg-pro12ala-polymorphism-and-20-year-cognitive-decline-race-and-sex-heterogeneity
#12
Nancy A West, Jonathan V Tingle, Jeannette Simino, Elizabeth Selvin, Jan Bressler, Thomas H Mosley
Previous reports suggest race/ethnic and sex heterogeneity in the association between the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor gamma (PPARG) gene and cognitive decline. Tests of verbal memory, processing speed, and verbal fluency and a composite global Z-score were used to assess cognitive performance longitudinally in a large (n=11,620) biracial cohort of older adults in the Atherosclerosis Risk in Communities Neurocognitive Study from midlife to older age. Linear mixed models were used to estimate associations between the Ala12 allele and cognitive performance over 20 years of follow-up...
November 7, 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/29077577/sporadic-cerebral-amyloid-angiopathy-with-cortical-occipital-calcifications-in-the-elderly
#13
Gaël Nicolas, Olivier Martinaud
No abstract text is available yet for this article.
October 26, 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/29028649/-18f-thk5351-pet-imaging-in-patients-with-semantic-variant-primary-progressive-aphasia
#14
Hyon Lee, Seongho Seo, Sang-Yoon Lee, Hye Jin Jeong, Sung-Ho Woo, Kyoung-Min Lee, Yeong-Bae Lee, Kee Hyung Park, Jae-Hyeok Heo, Cindy W Yoon, Jae Myeong Kang, Jaelim Cho, Nobuyuki Okamura, Shozo Furumoto, Kazuhiko Yanai, Duk L Na, Tatsuo Ido, Victor L Villemagne, Young Noh
BACKGROUND: Semantic variant primary progressive aphasia (svPPA) has been associated with a variety of proteinopathies, mainly transactive response DNA-binding protein, but also with tau and β-amyloid. Recently selective tau tracers for positron emission tomography (PET) have been developed to determine the presence of cerebral tau deposits in vivo. Here, we investigated the topographical distribution of THK5351 in svPPA patients. MATERIALS AND METHODS: Five svPPA patients, 14 Alzheimer's disease patients, and 15 age-matched normal controls underwent [F]-THK5351 PET scans, magnetic resonance imaging, and detailed neuropsychological tests...
October 12, 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/29028648/gintonin-administration-is-safe-and-potentially-beneficial-in-cognitively-impaired-elderly
#15
Jangsup Moon, Sun-Hye Choi, Ji-Young Shim, Hyun-Jung Park, Min-Jung Oh, Manho Kim, Seung-Yeol Nah
No abstract text is available yet for this article.
October 12, 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/29028647/change-in-engagement-in-cognitive-activity-and-risk-for-mild-cognitive-impairment-in-a-cohort-of-older-adults-the-monongahela-youghiogheny-healthy-aging-team-myhat-study
#16
Tiffany F Hughes, Zhaowen Sun, Chung-Chou H Chang, Mary Ganguli
Engagement in cognitively stimulating activities is gaining prominence as a potential strategy to maintain cognitive functioning in old age. In a population-based cohort of individuals aged 65+ years, we examined patterns of change in frequency of engagement in total cognitive activity (TCA), higher cognitive activity (HCA), and frequent cognitive activity (FCA) based on the Florida Cognitive Activities Scale over an average of 3.62 years, and whether these patterns were associated with incident mild cognitive impairment (MCI) during this same period...
October 12, 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/28984640/predictors-of-driving-cessation-in-dementia-baseline-characteristics-and-trajectories-of-disease-progression
#17
Michael H Connors, David Ames, Michael Woodward, Henry Brodaty
A diagnosis of dementia implies the eventual need to relinquish driving. This is associated with significant morbidity and anticipating when it will need to occur can be important for planning. Patients, however, vary in the course of their disease. We sought to identify predictors of driving cessation in patients with dementia, including both baseline characteristics and changes in cognition and function over time as indicators of disease trajectory. A total of 779 patients with dementia were recruited from 9 memory clinics around Australia...
October 3, 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/28984639/baseline-white-matter-hyperintensities-and-hippocampal-volume-are-associated-with-conversion-from-normal-cognition-to-mild-cognitive-impairment-in-the-framingham-offspring-study
#18
Katherine J Bangen, Sarah R Preis, Lisa Delano-Wood, Philip A Wolf, David J Libon, Mark W Bondi, Rhoda Au, Charles DeCarli, Adam M Brickman
INTRODUCTION: We examined associations between magnetic resonance imaging (MRI) markers of cerebrovascular disease and neurodegeneration with mild cognitive impairment (MCI) diagnosis at baseline and conversion from normal cognition to MCI at follow-up. METHODS: Framingham Offspring participants underwent brain MRI and neuropsychological assessment at baseline (n=1049) and follow-up (n=561). Participants were classified at baseline and at follow-up as cognitively normal or MCI using sensitive neuropsychological criteria...
October 3, 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/29166356/factors-related-to-different-objects-of-awareness-in-alzheimer-disease
#19
Isabel B Lacerda, Raquel L Santos, José Pedro Simões Neto, Marcia C N Dourado
Awareness of deficits is a multidimensional phenomenon described as the ability to acknowledge difficulties and impairments. We investigated whether unawareness affects distinct domains to different degrees and identified the factors related to the awareness impairment in Alzheimer Disease (AD). Using a cross-sectional design, we assessed 89 people with AD (PwAD) and their caregivers. Awareness was evaluated by scoring discrepant responses between PwAD and their caregivers across domains including cognitive functioning and health condition, functional activity impairments, emotional state, social functioning, and interpersonal relationships...
October 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/29016447/systemic-inflammation-in-lewy-body-diseases-a-systematic-review
#20
Eleanor King, Alan Thomas
Few studies have investigated the role of inflammation in Lewy body dementia (LBD) and variable results have been found. We systematically reviewed the literature for evidence of systemic inflammatory changes in dementia with Lewy bodies and Parkinson disease dementia. Owing to the low number of studies we also included Parkinson disease. Key terms were used to search the relevant databases. Titles and abstracts were screened and potentially relevant articles were reviewed in full. References of included studies and relevant reviews were searched...
October 2017: Alzheimer Disease and Associated Disorders
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