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Alzheimer Disease and Associated Disorders

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https://www.readbyqxmd.com/read/28121633/chorein-deficiency-and-alzheimer-disease-an-intriguing-yet-premature-speculation
#1
Antonio Velayos-Baeza, Adrian Danek
No abstract text is available yet for this article.
January 24, 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/28079535/heterozygous-deletion-of-chorein-exons-70-73-and-gna14-exons-3-7-in-a-brazilian-patient-presenting-with-probable-tau-negative-early-onset-alzheimer-disease
#2
Maciej J Lazarczyk, Sven Haller, Armand Savioz, Stefania Gimelli, Frédérique Bena, Panteleimon Giannakopoulos
No abstract text is available yet for this article.
January 10, 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/28030437/cerebrospinal-fluid-biomarkers-for-the-diagnosis-of-alzheimer-disease-in-south-korea
#3
Sun Ah Park, Won Seok Chae, Hyeong Jun Kim, Ho Sik Shin, Saeromi Kim, Ji Young Im, Sang Il Ahn, Kyoung Dae Min, Soo Jae Yim, Byoung Seok Ye, Sang Won Seo, Jee Hyang Jeong, Kyung Won Park, Seong Hye Choi, Duk L Na
Laboratory-specific reference values for cerebrospinal fluid (CSF) Alzheimer disease (AD) biomarkers are necessary. Our objective was to apply well-known CSF biomarkers and redetermine their diagnostic cutoff values for AD in South Korea. CSF samples from matched control subjects (n=71), patients with AD dementia (ADD, n=76), and other neurological disorders with cognitive decline (OND, n=47) were obtained from 6 Korean dementia clinics according to a standardized protocol. CSF biomarker concentrations were measured using enzyme-linked immunosorbent assay...
December 23, 2016: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/28005562/neuropsychological-testing-in-pathologically-verified-alzheimer-disease-and-frontotemporal-dementia-how-well-do-the-uniform-data-set-measures-differentiate-between-diseases
#4
Aaron R Ritter, Gabriel C Leger, Justin B Miller, Sarah J Banks
BACKGROUND/AIMS: Differences in cognition between frontotemporal dementia (FTD) and Alzheimer disease (AD) are well described in clinical cohorts, but have rarely been confirmed in studies with pathologic verification. For emerging therapeutics to succeed, determining underlying pathology early in the disease course is increasingly important. Neuropsychological evaluation is an important component of the diagnostic workup for AD and FTD. Patients with FTD are thought to have greater deficits in language and executive function while patients with AD are more likely to have deficits in memory...
December 21, 2016: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/28225507/high-hemoglobin-a1c-and-diabetes-predict-memory-decline-in-the-health-and-retirement-study
#5
Jessica R Marden, Elizabeth R Mayeda, Eric J Tchetgen Tchetgen, Ichiro Kawachi, M Maria Glymour
BACKGROUND: Type 2 diabetes (T2D) is an established risk factor for dementia, but evidence for T2D and memory decline is less consistent. Understanding how T2D and blood glucose relate to memory decline is crucial to elucidating the mechanisms linking T2D and dementia. MATERIALS AND METHODS: For 8888 Health and Retirement Study participants aged 50+, glycosylated hemoglobin (HbA1c) was measured in either 2006 or 2008 and physician's diagnosis of diabetes was self-reported in the same year...
January 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/28169841/time-sex-gender-history-and-dementia
#6
Walter A Rocca
A growing body of epidemiologic evidence indicates a decline in the incidence or prevalence of dementia in high income countries in the past 25 years. In this commentary, I first suggest that the decline in the incidence or prevalence of dementia is not explained completely by the factors considered so far, and that a broader historical perspective may be needed. Second, I suggest that the overall declining trend may conceal trends in opposite directions for the two major subtypes of dementia, the neurovascular and the neurodegenerative type...
January 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/28121634/fluorodeoxyglucose-positron-emission-tomography-fdg-pet-correlation-of-histopathology-and-mri-in-prion-disease
#7
Karin P Mente, James K O'Donnell, Stephen E Jones, Mark L Cohen, Nicolas R Thompson, Alberto Bizzi, Pierluigi Gambetti, Jiri G Safar, Brian S Appleby
Creutzfeldt-Jakob disease (CJD) and other prion diseases are rapidly progressive spongiform encephalopathies that are invariably fatal. Clinical features and magnetic resonance imaging, electroencephalogram, and cerebrospinal fluid abnormalities may suggest prion disease, but a definitive diagnosis can only be made by means of neuropathologic examination. Fluorodeoxyglucose positron emission tomography (FDG-PET) is not routinely used to evaluate patients with suspected prion disease. This study includes 11 cases of definite prion disease in which FDG-PET scans were obtained...
January 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/27819843/impact-of-functional-deficits-in-instrumental-activities-of-daily-living-in-mild-cognitive-impairment-a-clinical-algorithm-to-predict-progression-to-dementia
#8
Davangere P Devanand, Xinhua Liu, Patrick J Brown
BACKGROUND: The utility of functional deficits in patients with mild cognitive impairment is not established. MATERIALS AND METHODS: In 3886 individuals with mild cognitive impairment evaluated and followed at 34 National Alzheimer Coordinating Center sites, informant-reported Pfeffer Functional Activities Questionnaire (FAQ) items associated with progression to dementia were derived in a training set (n=1943) and tested in the validation set (n=1943). RESULTS: In the training set, the optimal combination comprised 6 FAQ items (FAQ6): difficulties with finances (2 items), remembering events/appointments, playing games of skill, current events, and travel...
January 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/27755004/diabetes-hemoglobin-a1c-and-regional-alzheimer-disease-and-infarct-pathology
#9
Jeremy J Pruzin, Julie A Schneider, Ana W Capuano, Sue E Leurgans, Lisa L Barnes, Rexford S Ahima, Steven E Arnold, David A Bennett, Zoe Arvanitakis
We examined the relationship of diabetes and hemoglobin A1C (A1C) to 2 common causes of dementia. The study included 1228 subjects who underwent annual clinical evaluations and a brain autopsy at death, as part of a Rush longitudinal cohort study of aging. A total of 433 subjects had A1C data available. Neuropathologic evaluations documented the size and location of infarcts. Modified silver stain-based Alzheimer disease (AD) measures included global and regional scores. We used regression analyses to examine associations of diabetes and A1C with overall and regional neuropathology...
January 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/27467026/mri-markers-predict-cognitive-decline-assessed-by-telephone-interview-the-northern-manhattan-study
#10
Clinton B Wright, Chuanhui Dong, Michelle R Caunca, Janet DeRosa, Ying Kuen Cheng, Tatjana Rundek, Mitchell S V Elkind, Charles DeCarli, Ralph L Sacco
BACKGROUND: Brain magnetic resonance imaging (MRI) allows researchers to observe structural pathology that may predict cognitive decline. Some populations are less accessible through traditional in-person visits, and may be under-represented in the literature. METHODS: We examined white matter hyperintensity volume (WMHV) and cerebral parenchymal fraction (CPF) as predictors of cognitive decline measured by a modified Telephone Interview for Cognitive Status (TICS-m) in the Northern Manhattan Stroke Study, a racially and ethnically diverse cohort study...
July 27, 2016: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/27196535/optimizing-effect-sizes-with-imaging-enrichment-and-outcome-choices-for-mild-alzheimer-disease-clinical-trials
#11
Timothy S Chang, Edmond Teng, David Elashoff, Joshua D Grill
Recent clinical trials in mild Alzheimer disease (AD) have enriched for amyloid-specific positron emission tomography (PET) imaging and used extended versions of the AD Assessment Scale-Cognitive Subscale (ADAS-Cog) in an effort to increase the sensitivity to detect treatment effects. We used data from mild AD participants in the AD Neuroimaging Initiative to model trial effect sizes for 12- and 24-month trials using 3 versions of the ADAS-Cog and increased standardized uptake value ratio (SUVR) cutoffs for amyloid imaging inclusion criteria...
January 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/27128959/amyloid-imaging-cerebrospinal-fluid-biomarkers-predict-driving-performance-among-cognitively-normal-individuals
#12
Catherine M Roe, Peggy P Barco, Denise M Head, Nupur Ghoshal, Natalie Selsor, Ganesh M Babulal, Rebecca Fierberg, Elizabeth K Vernon, Neal Shulman, Ann Johnson, Scot Fague, Chengjie Xiong, Elizabeth A Grant, Angela Campbell, Brian R Ott, David M Holtzman, Tammie L S Benzinger, Anne M Fagan, David B Carr, John C Morris
Postmortem brain studies of older drivers killed in car accidents indicate that many had Alzheimer disease (AD) neuropathologic changes. We examined whether AD biomarkers are related to driving performance among cognitively normal older adults. Individuals with normal cognition, aged 65+ years, and driving at least once per week, were recruited. Participants (N=129) took part in clinical assessments, a driving test, and positron emission tomography imaging with Pittsburgh compound B (PIB) and/or cerebrospinal fluid (CSF) collection...
January 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/27875364/attenuation-of-choroidal-thickness-in-patients-with-alzheimer-disease-evidence-from-an-italian-prospective-study
#13
Alessandro Trebbastoni, Michela Marcelli, Fabiana Mallone, Fabrizia D'Antonio, Letizia Imbriano, Alessandra Campanelli, Carlo de Lena, Magda Gharbiya
INTRODUCTION: To compare the 12-month choroidal thickness (CT) change between Alzheimer disease (AD) patients and normal subjects. METHODS: In this prospective, observational study, 39 patients with a diagnosis of mild to moderate AD and 39 age-matched control subjects were included. All the subjects underwent neuropsychological (Mini Mental State Examination, Alzheimer disease Assessment Scale-Cognitive Subscale, and the Clinical Dementia Rating Scale) and ophthalmological evaluation, including spectral domain optical coherence tomography, at baseline and after 12 months...
November 21, 2016: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/27849642/sarcopenia-is-associated-with-impairment-of-activities-of-daily-living-in-japanese-patients-with-early-stage-alzheimer-disease
#14
Taiki Sugimoto, Rei Ono, Shunsuke Murata, Naoki Saji, Yasumoto Matsui, Shumpei Niida, Kenji Toba, Takashi Sakurai
No abstract text is available yet for this article.
November 15, 2016: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/27849641/genetic-comparison-of-symptomatic-and-asymptomatic-persons-with-alzheimer-disease-neuropathology
#15
Sarah E Monsell, Charles Mock, David W Fardo, Sarah Bertelsen, Nigel J Cairns, Catherine M Roe, Sally R Ellingson, John C Morris, Alison M Goate, Walter A Kukull
OBJECTIVE: The objective was to determine whether symptomatic and asymptomatic persons with Alzheimer's disease (AD) neuropathology have different allele counts for single-nucleotide polymorphisms that have been associated with clinical late-onset AD. METHODS: Data came from the National Alzheimer's Coordinating Center Uniform Data Set and Neuropathology Data Set, and the Alzheimer's Disease Genetics Consortium (ADGC). Participants had low to high AD neuropathologic change...
November 15, 2016: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/27849640/rapidly-progressive-dementia-prevalence-and-causes-in-a-neurologic-unit-of-a-tertiary-hospital-in-brazil
#16
Adalberto Studart Neto, Herval R Soares Neto, Mateus M Simabukuro, Davi J F Solla, Márcia R R Gonçalves, Ida Fortini, Luiz H M Castro, Ricardo Nitrini
BACKGROUND: Rapidly progressive dementia (RPD) is usually associated with Creutzfeldt-Jakob disease, a fatal condition. Current advances in the understanding of immune-mediated diseases allow the diagnosis of previously unrecognized treatable RPDs. OBJECTIVE OF THE STUDY: The objective of the study was to describe the prevalence and causes of RPD in a neurology service, identifying potentially reversible causes. METHODS: We carried out a cross-sectional evaluation of all patients admitted to the neurology unit of a tertiary hospital in Brazil between March 2012 and February 2015...
November 15, 2016: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/27849639/wecareadvisor%C3%A2-the-development-of-a-caregiver-focused-web-based-program-to-assess-and-manage-behavioral-and-psychological-symptoms-of-dementia
#17
Helen C Kales, Laura N Gitlin, Barbara Stanislawski, Katherine Marx, Molly Turnwald, Daphne C Watkins, Constantine G Lyketsos
BACKGROUND/OBJECTIVES: Behavioral and psychological symptoms of dementia (BPSD) are nearly universal in dementia and associated with multiple negative outcomes. Current real-world management is largely pharmacologic, despite poor risk/benefit. The WeCareAdvisor was designed to enable family caregivers to assess, manage, and track BPSD using nonpharmacologic strategies. DESIGN: In-depth qualitative data were collected from family caregivers of people with dementia to inform: (1) style of approach and "look and feel" of the tool, and (2) the types of psychoeducation most needed by caregivers...
November 15, 2016: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/27849637/pneumonia-intake-problems-and-survival-among-nursing-home-residents-with-variable-stages-of-dementia-in-the-netherlands-results-from-a-prospective-observational-study
#18
Simone A Hendriks, Martin Smalbrugge, Arianne B van Gageldonk-Lafeber, Francisca Galindo-Garre, Maarten Schipper, Cees M P M Hertogh, Jenny T van der Steen
OBJECTIVES: We explored how pneumonia and intake problems affect survival in nursing home residents in variable stages of dementia. METHODS: In a longitudinal observational study (372 residents) with up to 3.5 years of follow-up, we examined relationships between dementia severity, the development of pneumonia, intake problems, and mortality using joint modeling, Cox models, and mediation analyses. Dementia severity was measured semiannually with the Bedford Alzheimer Nursing Severity-Scale (BANS-S)...
November 15, 2016: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/27819846/validity-of-death-certificate-and-hospital-discharge-icd-codes-for-dementia-diagnosis-the-multi-ethnic-study-of-atherosclerosis
#19
Akira Fujiyoshi, David R Jacobs, Alvaro Alonso, José A Luchsinger, Stephen R Rapp, Daniel A Duprez
No abstract text is available yet for this article.
November 4, 2016: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/27819845/the-potential-value-of-%C3%AE-amyloid-imaging-for-the-diagnosis-and-management-of-dementia-a-survey-of-clinicians
#20
Yue Zhong, Jason Karlawish, Meridith K Johnson, Peter J Neumann, Joshua T Cohen
We assessed the potential influence of β-amyloid imaging on clinician diagnoses and management of patients with memory loss. We surveyed 315 clinicians, assigning each a vignette describing a hypothetical patient with symptoms of unexplained mild cognitive impairment, possible Alzheimer disease (AD), or young-onset dementia. Vignettes reported "positive," "negative," or no β-amyloid imaging information. We assessed imaging's influence on diagnosis (AD contribution to symptoms), diagnostic confidence, and patient management...
November 4, 2016: Alzheimer Disease and Associated Disorders
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