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Alzheimer Disease and Associated Disorders

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https://www.readbyqxmd.com/read/28296666/temporal-trends-and-rural-urban-differences-in-hospital-length-of-stay-for-alzheimer-disease-and-related-disorders
#1
Samuel T Y Opoku, Bettye A Apenteng, Ge Lin
OBJECTIVES: The aim of this study was to assess rural-urban differences and temporal trends in length of inpatient stay among patients diagnosed with Alzheimer disease and related dementia (ADRD). MATERIALS AND METHODS: The study sample comprised 27,313 ADRD and 27,313 matched non-ADRD inpatient discharges from Nebraska hospitals from 2005 to 2011. Descriptive statistics and multivariable regression models were used to assess rural-urban variations and temporal trends in length of stay (LOS)...
March 14, 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/28288010/functional-connectivity-is-reduced-in-early-stage-primary-progressive-aphasia-when-atrophy-is-not-prominent
#2
Borna Bonakdarpour, Emily J Rogalski, Allan Wang, Jaiashre Sridhar, M M Mesulam, Robert S Hurley
Primary progressive aphasia (PPA) is a clinical syndrome of language decline caused by neurodegenerative pathology. Although language impairments in PPA are typically localized via the morphometric assessment of atrophy, functional changes may accompany or even precede detectable structural alterations, in which case resting state functional connectivity (RSFC) could provide an alternative approach. The goal of this study was to determine whether language network RSFC is reduced in early-stage PPA when atrophy is not prominent...
March 10, 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/28263191/coronary-artery-bypass-graft-surgery-and-dementia-risk-in-the-cardiovascular-health-study
#3
Elżbieta Kuźma, Jac Airdrie, Thomas J Littlejohns, Ilianna Lourida, Jo Thompson-Coon, Iain A Lang, Monica Scrobotovici, Evan L Thacker, Annette Fitzpatrick, Lewis H Kuller, Oscar L Lopez, William T Longstreth, Obioha C Ukoumunne, David J Llewellyn
INTRODUCTION: The association between history of coronary artery bypass graft surgery (CABG) and dementia risk remains unclear. METHODS: We conducted a prospective cohort analysis using data on 3155 elderly adults free from prevalent dementia from the US population-based Cardiovascular Health Study (CHS) with adjudicated incident all-cause dementia, Alzheimer disease (AD), vascular dementia (VaD), and mixed dementia. RESULTS: In the CHS, the hazard ratio (HR) for all-cause dementia was 1...
March 3, 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/28248688/change-in-health-related-quality-of-life-after-referral-to-memory-assessment-services
#4
Min Hae Park, Sarah C Smith, Theopisti Chrysanthaki, Jenny Neuburger, Craig W Ritchie, A A Jolijn Hendriks, Nick Black
Despite strong support for the provision of memory assessment services (MASs) in England and other countries, their effectiveness in improving patient outcomes is uncertain. We aimed to describe change in patients' health-related quality of life (HRQL) 6 months after referral to MASs and to examine associations with patient characteristics and use of postdiagnostic interventions. Data from 883 patients referred to 69 MASs and their informal caregivers (n=569) were collected at referral and 6 months later. Multivariable linear regression was used to examine associations of change in HRQL (DEMQOL, DEMQOL-Proxy) with patient characteristics (age, sex, ethnicity, socioeconomic deprivation, and comorbidity) and use of postdiagnostic interventions (antidementia medications and nonpharmacological therapies)...
February 28, 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/28225507/high-hemoglobin-a1c-and-diabetes-predict-memory-decline-in-the-health-and-retirement-study
#5
Jessica R Marden, Elizabeth R Mayeda, Eric J Tchetgen Tchetgen, Ichiro Kawachi, M Maria Glymour
BACKGROUND: Type 2 diabetes (T2D) is an established risk factor for dementia, but evidence for T2D and memory decline is less consistent. Understanding how T2D and blood glucose relate to memory decline is crucial to elucidating the mechanisms linking T2D and dementia. MATERIALS AND METHODS: For 8888 Health and Retirement Study participants aged 50+, glycosylated hemoglobin (HbA1c) was measured in either 2006 or 2008 and physician's diagnosis of diabetes was self-reported in the same year...
January 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/28169841/time-sex-gender-history-and-dementia
#6
Walter A Rocca
A growing body of epidemiologic evidence indicates a decline in the incidence or prevalence of dementia in high income countries in the past 25 years. In this commentary, I first suggest that the decline in the incidence or prevalence of dementia is not explained completely by the factors considered so far, and that a broader historical perspective may be needed. Second, I suggest that the overall declining trend may conceal trends in opposite directions for the two major subtypes of dementia, the neurovascular and the neurodegenerative type...
January 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/28121634/fluorodeoxyglucose-positron-emission-tomography-fdg-pet-correlation-of-histopathology-and-mri-in-prion-disease
#7
Karin P Mente, James K O'Donnell, Stephen E Jones, Mark L Cohen, Nicolas R Thompson, Alberto Bizzi, Pierluigi Gambetti, Jiri G Safar, Brian S Appleby
Creutzfeldt-Jakob disease (CJD) and other prion diseases are rapidly progressive spongiform encephalopathies that are invariably fatal. Clinical features and magnetic resonance imaging, electroencephalogram, and cerebrospinal fluid abnormalities may suggest prion disease, but a definitive diagnosis can only be made by means of neuropathologic examination. Fluorodeoxyglucose positron emission tomography (FDG-PET) is not routinely used to evaluate patients with suspected prion disease. This study includes 11 cases of definite prion disease in which FDG-PET scans were obtained...
January 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/28121633/chorein-deficiency-and-alzheimer-disease-an-intriguing-yet-premature-speculation
#8
Antonio Velayos-Baeza, Adrian Danek
No abstract text is available yet for this article.
January 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/28079535/heterozygous-deletion-of-chorein-exons-70-73-and-gna14-exons-3-7-in-a-brazilian-patient-presenting-with-probable-tau-negative-early-onset-alzheimer-disease
#9
Maciej J Lazarczyk, Sven Haller, Armand Savioz, Stefania Gimelli, Frédérique Bena, Panteleimon Giannakopoulos
No abstract text is available yet for this article.
January 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/28030437/cerebrospinal-fluid-biomarkers-for-the-diagnosis-of-alzheimer-disease-in-south-korea
#10
Sun Ah Park, Won Seok Chae, Hyeong Jun Kim, Ho Sik Shin, Saeromi Kim, Ji Young Im, Sang Il Ahn, Kyoung Dae Min, Soo Jae Yim, Byoung Seok Ye, Sang Won Seo, Jee Hyang Jeong, Kyung Won Park, Seong Hye Choi, Duk L Na
Laboratory-specific reference values for cerebrospinal fluid (CSF) Alzheimer disease (AD) biomarkers are necessary. Our objective was to apply well-known CSF biomarkers and redetermine their diagnostic cutoff values for AD in South Korea. CSF samples from matched control subjects (n=71), patients with AD dementia (ADD, n=76), and other neurological disorders with cognitive decline (OND, n=47) were obtained from 6 Korean dementia clinics according to a standardized protocol. CSF biomarker concentrations were measured using enzyme-linked immunosorbent assay...
January 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/27819843/impact-of-functional-deficits-in-instrumental-activities-of-daily-living-in-mild-cognitive-impairment-a-clinical-algorithm-to-predict-progression-to-dementia
#11
Davangere P Devanand, Xinhua Liu, Patrick J Brown
BACKGROUND: The utility of functional deficits in patients with mild cognitive impairment is not established. MATERIALS AND METHODS: In 3886 individuals with mild cognitive impairment evaluated and followed at 34 National Alzheimer Coordinating Center sites, informant-reported Pfeffer Functional Activities Questionnaire (FAQ) items associated with progression to dementia were derived in a training set (n=1943) and tested in the validation set (n=1943). RESULTS: In the training set, the optimal combination comprised 6 FAQ items (FAQ6): difficulties with finances (2 items), remembering events/appointments, playing games of skill, current events, and travel...
January 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/27819842/low-dose-lithium-treatment-for-agitation-and-psychosis-in-alzheimer-disease-and-frontotemporal-dementia-a-case-series
#12
Davangere P Devanand, Gregory H Pelton, Kristina D'Antonio, Jesse G Strickler, William C Kreisl, James Noble, Karen Marder, Anne Skomorowsky, Edward D Huey
No abstract text is available yet for this article.
January 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/27755004/diabetes-hemoglobin-a1c-and-regional-alzheimer-disease-and-infarct-pathology
#13
Jeremy J Pruzin, Julie A Schneider, Ana W Capuano, Sue E Leurgans, Lisa L Barnes, Rexford S Ahima, Steven E Arnold, David A Bennett, Zoe Arvanitakis
We examined the relationship of diabetes and hemoglobin A1C (A1C) to 2 common causes of dementia. The study included 1228 subjects who underwent annual clinical evaluations and a brain autopsy at death, as part of a Rush longitudinal cohort study of aging. A total of 433 subjects had A1C data available. Neuropathologic evaluations documented the size and location of infarcts. Modified silver stain-based Alzheimer disease (AD) measures included global and regional scores. We used regression analyses to examine associations of diabetes and A1C with overall and regional neuropathology...
January 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/27680780/cholinergic-changes-in-aging-and-alzheimer-disease-an-18f-f-a-85380-exploratory-pet-study
#14
Julien Lagarde, Marie Sarazin, Valérie Chauviré, Bruno Stankoff, Aurélie Kas, Lucette Lacomblez, Marie-Anne Peyronneau, Michel Bottlaender
The central cholinergic system undergoes changes during the physiological process of aging and the pathologic process of Alzheimer disease (AD). We aimed to analyze the impairment of cholinergic pathways by positron emission tomography using the [F]-F-A-85380 (FA85) tracer, which has a high affinity for nicotinic acetylcholine receptors (nAChRs). Aging was assessed by comparing young (n=10) and elderly (n=4) healthy subjects, and the pathologic process of AD was assessed by comparing elderly controls and age-matched AD patients (n=8)...
January 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/27467026/mri-markers-predict-cognitive-decline-assessed-by-telephone-interview-the-northern-manhattan-study
#15
Clinton B Wright, Chuanhui Dong, Michelle R Caunca, Janet DeRosa, Ying Kuen Cheng, Tatjana Rundek, Mitchell S V Elkind, Charles DeCarli, Ralph L Sacco
BACKGROUND: Brain magnetic resonance imaging (MRI) allows researchers to observe structural pathology that may predict cognitive decline. Some populations are less accessible through traditional in-person visits, and may be under-represented in the literature. METHODS: We examined white matter hyperintensity volume (WMHV) and cerebral parenchymal fraction (CPF) as predictors of cognitive decline measured by a modified Telephone Interview for Cognitive Status (TICS-m) in the Northern Manhattan Stroke Study, a racially and ethnically diverse cohort study...
January 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/27196535/optimizing-effect-sizes-with-imaging-enrichment-and-outcome-choices-for-mild-alzheimer-disease-clinical-trials
#16
Timothy S Chang, Edmond Teng, David Elashoff, Joshua D Grill
Recent clinical trials in mild Alzheimer disease (AD) have enriched for amyloid-specific positron emission tomography (PET) imaging and used extended versions of the AD Assessment Scale-Cognitive Subscale (ADAS-Cog) in an effort to increase the sensitivity to detect treatment effects. We used data from mild AD participants in the AD Neuroimaging Initiative to model trial effect sizes for 12- and 24-month trials using 3 versions of the ADAS-Cog and increased standardized uptake value ratio (SUVR) cutoffs for amyloid imaging inclusion criteria...
January 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/27128959/amyloid-imaging-cerebrospinal-fluid-biomarkers-predict-driving-performance-among-cognitively-normal-individuals
#17
Catherine M Roe, Peggy P Barco, Denise M Head, Nupur Ghoshal, Natalie Selsor, Ganesh M Babulal, Rebecca Fierberg, Elizabeth K Vernon, Neal Shulman, Ann Johnson, Scot Fague, Chengjie Xiong, Elizabeth A Grant, Angela Campbell, Brian R Ott, David M Holtzman, Tammie L S Benzinger, Anne M Fagan, David B Carr, John C Morris
Postmortem brain studies of older drivers killed in car accidents indicate that many had Alzheimer disease (AD) neuropathologic changes. We examined whether AD biomarkers are related to driving performance among cognitively normal older adults. Individuals with normal cognition, aged 65+ years, and driving at least once per week, were recruited. Participants (N=129) took part in clinical assessments, a driving test, and positron emission tomography imaging with Pittsburgh compound B (PIB) and/or cerebrospinal fluid (CSF) collection...
January 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/28005562/neuropsychological-testing-in-pathologically-verified-alzheimer-disease-and-frontotemporal-dementia-how-well-do-the-uniform-data-set-measures-differentiate-between-diseases
#18
Aaron R Ritter, Gabriel C Leger, Justin B Miller, Sarah J Banks
BACKGROUND/AIMS: Differences in cognition between frontotemporal dementia (FTD) and Alzheimer disease (AD) are well described in clinical cohorts, but have rarely been confirmed in studies with pathologic verification. For emerging therapeutics to succeed, determining underlying pathology early in the disease course is increasingly important. Neuropsychological evaluation is an important component of the diagnostic workup for AD and FTD. Patients with FTD are thought to have greater deficits in language and executive function while patients with AD are more likely to have deficits in memory...
December 21, 2016: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/27875364/attenuation-of-choroidal-thickness-in-patients-with-alzheimer-disease-evidence-from-an-italian-prospective-study
#19
Alessandro Trebbastoni, Michela Marcelli, Fabiana Mallone, Fabrizia D'Antonio, Letizia Imbriano, Alessandra Campanelli, Carlo de Lena, Magda Gharbiya
INTRODUCTION: To compare the 12-month choroidal thickness (CT) change between Alzheimer disease (AD) patients and normal subjects. METHODS: In this prospective, observational study, 39 patients with a diagnosis of mild to moderate AD and 39 age-matched control subjects were included. All the subjects underwent neuropsychological (Mini Mental State Examination, Alzheimer disease Assessment Scale-Cognitive Subscale, and the Clinical Dementia Rating Scale) and ophthalmological evaluation, including spectral domain optical coherence tomography, at baseline and after 12 months...
November 21, 2016: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/27849642/sarcopenia-is-associated-with-impairment-of-activities-of-daily-living-in-japanese-patients-with-early-stage-alzheimer-disease
#20
Taiki Sugimoto, Rei Ono, Shunsuke Murata, Naoki Saji, Yasumoto Matsui, Shumpei Niida, Kenji Toba, Takashi Sakurai
No abstract text is available yet for this article.
November 15, 2016: Alzheimer Disease and Associated Disorders
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