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Alzheimer Disease and Associated Disorders

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https://www.readbyqxmd.com/read/29028649/-18f-thk5351-pet-imaging-in-patients-with-semantic-variant-primary-progressive-aphasia
#1
Hyon Lee, Seongho Seo, Sang-Yoon Lee, Hye Jin Jeong, Sung-Ho Woo, Kyoung-Min Lee, Yeong-Bae Lee, Kee Hyung Park, Jae-Hyeok Heo, Cindy W Yoon, Jae Myeong Kang, Jaelim Cho, Nobuyuki Okamura, Shozo Furumoto, Kazuhiko Yanai, Duk L Na, Tatsuo Ido, Victor L Villemagne, Young Noh
BACKGROUND: Semantic variant primary progressive aphasia (svPPA) has been associated with a variety of proteinopathies, mainly transactive response DNA-binding protein, but also with tau and β-amyloid. Recently selective tau tracers for positron emission tomography (PET) have been developed to determine the presence of cerebral tau deposits in vivo. Here, we investigated the topographical distribution of THK5351 in svPPA patients. MATERIALS AND METHODS: Five svPPA patients, 14 Alzheimer's disease patients, and 15 age-matched normal controls underwent [F]-THK5351 PET scans, magnetic resonance imaging, and detailed neuropsychological tests...
October 12, 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/29028648/gintonin-administration-is-safe-and-potentially-beneficial-in-cognitively-impaired-elderly
#2
Jangsup Moon, Sun-Hye Choi, Ji-Young Shim, Hyun-Jung Park, Min-Jung Oh, Manho Kim, Seung-Yeol Nah
No abstract text is available yet for this article.
October 12, 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/29028647/change-in-engagement-in-cognitive-activity-and-risk-for-mild-cognitive-impairment-in-a-cohort-of-older-adults-the-monongahela-youghiogheny-healthy-aging-team-myhat-study
#3
Tiffany F Hughes, Zhaowen Sun, Chung-Chou H Chang, Mary Ganguli
Engagement in cognitively stimulating activities is gaining prominence as a potential strategy to maintain cognitive functioning in old age. In a population-based cohort of individuals aged 65+ years, we examined patterns of change in frequency of engagement in total cognitive activity (TCA), higher cognitive activity (HCA), and frequent cognitive activity (FCA) based on the Florida Cognitive Activities Scale over an average of 3.62 years, and whether these patterns were associated with incident mild cognitive impairment (MCI) during this same period...
October 12, 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/29016447/systemic-inflammation-in-lewy-body-diseases-a-systematic-review
#4
Eleanor King, Alan Thomas
Few studies have investigated the role of inflammation in Lewy body dementia (LBD) and variable results have been found. We systematically reviewed the literature for evidence of systemic inflammatory changes in dementia with Lewy bodies and Parkinson disease dementia. Owing to the low number of studies we also included Parkinson disease. Key terms were used to search the relevant databases. Titles and abstracts were screened and potentially relevant articles were reviewed in full. References of included studies and relevant reviews were searched...
October 9, 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/28984640/predictors-of-driving-cessation-in-dementia-baseline-characteristics-and-trajectories-of-disease-progression
#5
Michael H Connors, David Ames, Michael Woodward, Henry Brodaty
A diagnosis of dementia implies the eventual need to relinquish driving. This is associated with significant morbidity and anticipating when it will need to occur can be important for planning. Patients, however, vary in the course of their disease. We sought to identify predictors of driving cessation in patients with dementia, including both baseline characteristics and changes in cognition and function over time as indicators of disease trajectory. A total of 779 patients with dementia were recruited from 9 memory clinics around Australia...
October 3, 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/28984639/baseline-white-matter-hyperintensities-and-hippocampal-volume-are-associated-with-conversion-from-normal-cognition-to-mild-cognitive-impairment-in-the-framingham-offspring-study
#6
Katherine J Bangen, Sarah R Preis, Lisa Delano-Wood, Philip A Wolf, David J Libon, Mark W Bondi, Rhoda Au, Charles DeCarli, Adam M Brickman
INTRODUCTION: We examined associations between magnetic resonance imaging (MRI) markers of cerebrovascular disease and neurodegeneration with mild cognitive impairment (MCI) diagnosis at baseline and conversion from normal cognition to MCI at follow-up. METHODS: Framingham Offspring participants underwent brain MRI and neuropsychological assessment at baseline (n=1049) and follow-up (n=561). Participants were classified at baseline and at follow-up as cognitively normal or MCI using sensitive neuropsychological criteria...
October 3, 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/28891819/factors-influencing-successful-lumbar-puncture-in-alzheimer-research
#7
Krista L Moulder, Lilah M Besser, Duane Beekly, Kaj Blennow, Walter Kukull, John C Morris
OBJECTIVE: Lumbar puncture (LP) is increasingly common in Alzheimer disease research; however, agreement to undergo LP varies. We sought to determine factors influencing LP consent at Alzheimer's Disease Centers (ADCs) in the United States. METHODS: A 3-part survey was distributed to each ADC: (1) ADC LP Experience; (2) LP Requestor Experience; and (3) Patient LP Experience (both Initial and Follow-up). In all, 64 LP Requestor, 579 Patient/Initial, and 404 Patient/Follow-up surveys were collected...
September 7, 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/28891818/machine-learning-support-to-individual-diagnosis-of-mild-cognitive-impairment-using-multimodal-mri-and-cognitive-assessments
#8
Matteo De Marco, Leandro Beltrachini, Alberto Biancardi, Alejandro F Frangi, Annalena Venneri
BACKGROUND: Understanding whether the cognitive profile of a patient indicates mild cognitive impairment (MCI) or performance levels within normality is often a clinical challenge. The use of resting-state functional magnetic resonance imaging (RS-fMRI) and machine learning may represent valid aids in clinical settings for the identification of MCI patients. METHODS: Machine-learning models were computed to test the classificatory accuracy of cognitive, volumetric [structural magnetic resonance imaging (sMRI)] and blood oxygen level dependent-connectivity (extracted from RS-fMRI) features, in single-modality and mixed classifiers...
September 7, 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/28796011/the-nature-and-natural-history-of-posterior-cortical-atrophy-syndrome-a-variant-of-early-onset-alzheimer-disease
#9
Peter K Panegyres, Judy Goh, Michael McCarthy, Andrew I Campbell
A prospective longitudinal evaluation of 12 patients over a 16-year interval using clinical neurological and imaging data to determine whether posterior cortical atrophy syndrome (PCA) related to early-onset Alzheimer disease (AD) and to examine its natural history. Our 12 patients had a median age of onset of 56 years (range, 48 to 63 y) and were followed for a median of 6 years (range, 3 to 9 y). Patients either presented with complex visual phenomena or developed them with time. Six patients underwent flurodeoxyglucose and Pittsburgh investigational compound B imaging which showed a mismatch between metabolic activity and amyloid deposition with reduced metabolism in parieto-occipital regions on flurodeoxyglucose positron emission tomography and diffuse neocortical uptake of amyloid without occipital predominance...
August 8, 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/28796010/the-report-of-p-val717phe-mutation-in-the-app-gene-in-a-hungarian-family-with-alzheimer-disease-a-phenomenological-study
#10
Dénes Zádori, Judit Füvesi, Erzsébet Timár, Emese Horváth, Renáta Bencsik, Noémi Szépfalusi, Anita Must, László Vécsei, Mária Judit Molnár, Péter Klivényi
No abstract text is available yet for this article.
August 8, 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/28796009/different-exposures-to-risk-factors-do-not-explain-the-inverse-relationship-of-occurrence-between-cancer-and-neurodegenerative-diseases-an-italian-nested-case-control-study
#11
Federica Prinelli, Fulvio Adorni, Maria Lea Correa Leite, Carla Pettenati, Antonio Russo, Simona Di Santo, Massimo Musicco
Several studies reported that cancer is less frequent in persons with Alzheimer's and Parkinson's Diseases (AD/PD) and vice-versa. We evaluated whether a different distribution of known nongenetic risk factors for cancer and AD/PD, might explain their inverse relationship of occurrence. We nested 2 case-control studies in a subsample of a large cohort of 1,000,000 resident in Lombardy Region in Italy (n=1515), followed-up for cancer and AD/PD occurrence since 1991 until 2012. Conditional logistic regression was performed to determine the odds ratios (OR) and 95% confidence intervals (CI) of AD/PD in subjects with and without cancer and the risk of cancer in those with and without AD/PD...
August 8, 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/28700383/the-use-of-the-clinical-dementia-rating-scale-sum-of-boxes-scores-in-detecting-and-staging-cognitive-impairment-dementia-in-brazilian-patients-with-low-educational-attainment
#12
Andrea P V Lima, Raphael Castilhos, Marcia L F Chaves
The aim of this study was to evaluate the Clinical Dementia Rating Scale sum of the boxes (CDR-SB) diagnostic validity in detecting and staging cognitive impairment/dementia in a sample of Brazilian patients with amnestic mild cognitive impairment (aMCI), Alzheimer disease (AD), and vascular dementia (VD), of low educational attainment. Data were obtained from the Dementia Clinic of Hospital de Clínicas de Porto Alegre database and included 407 participants (115 healthy elderly, 41 aMCI, 165 AD, and 86 VD)...
July 11, 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/28486240/dependence-stage-and-pharmacoeconomic-outcomes-in-patients-with-alzheimer-disease
#13
Tzeyu L Michaud, Robin High, Mary E Charlton, Daniel L Murman
The level of assistance patients with Alzheimer disease (AD) require in their care may be an important predictor of resource use, costs of care, and quality of life. The Dependence Scale (DS), a measure of care-assistance required, was used to estimate costs of care and quality of life of patients with AD categorized into 6 dependence stages based upon the summated item scores of the DS. Data were derived from a 3-year, noninterventional study of 132 patients with probable AD (ages, 50 to 85 y) and caregiver dyads...
July 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/28406845/heterogeneity-in-14-year-dementia-incidence-between-asian-american-subgroups
#14
Elizabeth R Mayeda, M Maria Glymour, Charles P Quesenberry, Rachel A Whitmer
BACKGROUND: Asian Americans are a rapidly growing and diverse population. Prior research on dementia among Asian Americans focused on Japanese Americans or Asian Americans overall, although marked differences in cardiometabolic conditions between subgroups have been documented. MATERIALS AND METHODS: We compared dementia incidence among 4 Asian American subgroups (n=8384 Chinese; n=4478 Japanese; n=6210 Filipino; n=197 South Asian) and whites (n=206,490) who were Kaiser Permanente Northern California members aged 64 years and above with no dementia diagnoses as of January 1, 2000...
July 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/28369008/genetic-ancestry-and-susceptibility-to-late-onset-alzheimer-disease-load-in-the-admixed-colombian-population
#15
Diana J Moreno, Sebastián Pino, Ángela Ríos, Francisco Lopera, Henry Ostos, Marc Via, Gabriel Bedoya
INTRODUCTION: Differences in the prevalence of dementia among populations and in the effect of apolipoprotein E (APOE) on the emergence of Alzheimer disease (AD), which is the main type of dementia, have been reported. METHODS: This study estimated the ancestry of a group of individuals with late-onset Alzheimer disease (LOAD) (N=280) and established whether there were any differences when compared with a control group (N=357) in a sample of the Colombian population...
July 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/28338508/autoimmune-frontotemporal-dementia-a-new-nosological-entity
#16
Barbara Borroni, Marta A Manes, Antonella Alberici, Maura Cosseddu, Pia Bernasconi, Silvana Archetti, Lorenzo Pinelli, Roberto Gasparotti, Alessandro Padovani
No abstract text is available yet for this article.
July 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/28296666/temporal-trends-and-rural-urban-differences-in-hospital-length-of-stay-for-alzheimer-disease-and-related-disorders
#17
Samuel T Y Opoku, Bettye A Apenteng, Ge Lin
OBJECTIVES: The aim of this study was to assess rural-urban differences and temporal trends in length of inpatient stay among patients diagnosed with Alzheimer disease and related dementia (ADRD). MATERIALS AND METHODS: The study sample comprised 27,313 ADRD and 27,313 matched non-ADRD inpatient discharges from Nebraska hospitals from 2005 to 2011. Descriptive statistics and multivariable regression models were used to assess rural-urban variations and temporal trends in length of stay (LOS)...
July 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/28248688/change-in-health-related-quality-of-life-after-referral-to-memory-assessment-services
#18
Min Hae Park, Sarah C Smith, Theopisti Chrysanthaki, Jenny Neuburger, Craig W Ritchie, A A Jolijn Hendriks, Nick Black
Despite strong support for the provision of memory assessment services (MASs) in England and other countries, their effectiveness in improving patient outcomes is uncertain. We aimed to describe change in patients' health-related quality of life (HRQL) 6 months after referral to MASs and to examine associations with patient characteristics and use of postdiagnostic interventions. Data from 883 patients referred to 69 MASs and their informal caregivers (n=569) were collected at referral and 6 months later. Multivariable linear regression was used to examine associations of change in HRQL (DEMQOL, DEMQOL-Proxy) with patient characteristics (age, sex, ethnicity, socioeconomic deprivation, and comorbidity) and use of postdiagnostic interventions (antidementia medications and nonpharmacological therapies)...
July 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/28005562/neuropsychological-testing-in-pathologically-verified-alzheimer-disease-and-frontotemporal-dementia-how-well-do-the-uniform-data-set-measures-differentiate-between-diseases
#19
Aaron R Ritter, Gabriel C Leger, Justin B Miller, Sarah J Banks
BACKGROUND/AIMS: Differences in cognition between frontotemporal dementia (FTD) and Alzheimer disease (AD) are well described in clinical cohorts, but have rarely been confirmed in studies with pathologic verification. For emerging therapeutics to succeed, determining underlying pathology early in the disease course is increasingly important. Neuropsychological evaluation is an important component of the diagnostic workup for AD and FTD. Patients with FTD are thought to have greater deficits in language and executive function while patients with AD are more likely to have deficits in memory...
July 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/27849642/sarcopenia-is-associated-with-impairment-of-activities-of-daily-living-in-japanese-patients-with-early-stage-alzheimer-disease
#20
Taiki Sugimoto, Rei Ono, Shunsuke Murata, Naoki Saji, Yasumoto Matsui, Shumpei Niida, Kenji Toba, Takashi Sakurai
No abstract text is available yet for this article.
July 2017: Alzheimer Disease and Associated Disorders
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