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Alzheimer Disease and Associated Disorders

Corinne Pettigrew, Yi Shao, Yuxin Zhu, Maura Grega, Rostislav Brichko, Mei-Cheng Wang, Michelle C Carlson, Marilyn Albert, Anja Soldan
BACKGROUND: Few studies have examined the relationship between lifestyle activity engagement and cognitive trajectories among individuals who were cognitively normal at baseline. OBJECTIVE: To examine the relationship of current engagement in lifestyle activities to previous cognitive performance among individuals who were cognitively normal at baseline, and whether this relationship differed for individuals who subsequently developed mild cognitive impairment (MCI), or by APOE-4 genotype, age, and level of cognitive reserve...
October 29, 2018: Alzheimer Disease and Associated Disorders
Lilah Besser, Walter Kukull, David S Knopman, Helena Chui, Douglas Galasko, Sandra Weintraub, Gregory Jicha, Cynthia Carlsson, Jeffrey Burns, Joseph Quinn, Robert A Sweet, Katya Rascovsky, Merilee Teylan, Duane Beekly, George Thomas, Mark Bollenbeck, Sarah Monsell, Charles Mock, Xiao Hua Zhou, Nicole Thomas, Elizabeth Robichaud, Margaret Dean, Janene Hubbard, Mary Jacka, Kristen Schwabe-Fry, Joylee Wu, Creighton Phelps, John C Morris
INTRODUCTION: In 2015, the US Alzheimer's Disease Centers (ADC) implemented Version 3 of the Uniform Data Set (UDS). This paper describes the history of Version 3 development and the UDS data that are freely available to researchers. METHODS: UDS Version 3 was developed after years of coordination between the National Institute on Aging-appointed Clinical Task Force (CTF), clinicians from ∼30 ADCs, and the National Alzheimer's Coordinating Center (NACC). The CTF recognized the need for updates to align with the state of the science in dementia research, while being flexible to the diverse needs and diseases studied at the ADCs...
October 29, 2018: Alzheimer Disease and Associated Disorders
Bieke Van Deun, Nele Van Den Noortgate, Anke Van Bladel, Tanneke Palmans, Dirk Cambier
BACKGROUND: Dementia is associated with impairment in gait, balance, and fine motor function. Paratonia, a form of hypertonia, is often present in severe dementia. However, little is known about muscle tone in early dementia, and the eventual relation between muscle tone abnormalities and changes in fine and gross motor function. METHODS: Three groups of participants were included in the study: healthy controls (n=60), participants with mild dementia (MiD) (n=31), and participants with moderate dementia (n=31)...
October 26, 2018: Alzheimer Disease and Associated Disorders
Jennifer S Albrecht, Maya Hanna, Dure Kim, Eleanor M Perfetto
INTRODUCTION: Prior studies have reported higher health care utilization (HCU) leading up to diagnosis of the Alzheimer disease and related dementia (ADRD), but none have assessed variation in HCU by ADRD subtype or examined disease-specific HCU. The objectives of this study were to identify ADRD subtypes and: (1) characterize all-cause and (2) disease-specific HCU during the 3 years preceding diagnosis, and (3) determine if HCU varied by ADRD subtype. METHODS: We used data from the OptumLabs Data Warehouse 2008 to 2014 to identify ADRD subtypes (total N=36,838) using an algorithm based on temporal sequencing of diagnoses and provider type...
October 5, 2018: Alzheimer Disease and Associated Disorders
Carlos E Arboleda-Bustos, Jenny Ortega-Rojas, María F Mahecha, Gonzalo Arboleda, Rafael Vásquez, Rodrigo Pardo, Humberto Arboleda
OBJECTIVE: We evaluated the association of several single-nucleotide polymorphisms in the triggering receptor expressed on myeloid cells 2 (TREM2) gene in a Colombian sample of late-onset Alzheimer disease (LOAD). METHODS: The p.Q33* (rs104894002), p.R47H (rs75932628), p.R62H (rs143332484), and p.D87N (rs142232675) variants of TREM2 gene were directly genotyped using KASPar technology in 358 cases and 329 healthy controls. Sanger sequencing was used to validate >10% of KASPar's results...
September 14, 2018: Alzheimer Disease and Associated Disorders
Gregory S Day, Erik S Musiek, John C Morris
BACKGROUND: Published approaches to the evaluation and management of patients with rapidly progressive dementia (RPD) have been largely informed by experience at academic hospitals and national centers specializing in the diagnosis of Creutzfeldt-Jakob disease. Whether these approaches can be applied to patients assessed within lower-acuity outpatient settings is unknown. METHODS: A total of 96 patients with suspected RPD were assessed within the Washington University School of Medicine (Saint Louis, MO) outpatient memory clinic from February 2006 to February 2016...
September 14, 2018: Alzheimer Disease and Associated Disorders
Richard J Caselli, Blake T Langlais, Amylou C Dueck, Dona E C Locke, Bryan K Woodruff
INTRODUCTION: Roughly 4% to 23% of the population embody stress prone personality and other traits characterizing a subclinical "broad autism phenotype" (BAP). Subjective cognitive impairment (SCI) among healthy elderly is associated with psychological distress leading us to predict BAP would be associated with SCI. METHODS: The Autism Spectrum Quotient, a self-administered 50 item questionnaire, was completed by 419 consecutive members of the Arizona APOE Cohort who underwent neuropsychological testing every 2 years...
September 11, 2018: Alzheimer Disease and Associated Disorders
Stella Gagliardi, Annalisa Davin, Paola Bini, Elena Sinforiani, Tino E Poloni, Letizia Polito, Chiara Rivoiro, Giuliano Binetti, Anna Paterlini, Luisa Benussi, Roberta Ghidoni, Nicola Vanacore, Cristina Cereda
No abstract text is available yet for this article.
September 4, 2018: Alzheimer Disease and Associated Disorders
Chelsea L Sanders, Heidi J Wengreen, Sarah Schwartz, Stephanie J Behrens, Chris Corcoran, Constantine G Lyketsos, JoAnn T Tschanz
PURPOSE: Studies have reported faster cognitive/functional decline in persons with dementia (PWD) with malnutrition. We investigated whether baseline nutritional status predicted severe dementia and mortality in a population-based sample. PATIENTS: A maximum of 300 PWD were assessed annually for up to 8.6 years. METHODS: Nutritional status was assessed using a modified Mini-Nutritional Assessment (mMNA). Severe dementia was defined as: "severe" rating on the Clinical Dementia Rating or Mini-Mental State Examination score ≤10...
September 4, 2018: Alzheimer Disease and Associated Disorders
Jennie L Wells, Stephen H Pasternak
No abstract text is available yet for this article.
August 24, 2018: Alzheimer Disease and Associated Disorders
John C Williamson, Andrew J Larner
No abstract text is available yet for this article.
August 13, 2018: Alzheimer Disease and Associated Disorders
Anne-Brita Knapskog, Anne Braekhus, Knut Engedal
No abstract text is available yet for this article.
August 13, 2018: Alzheimer Disease and Associated Disorders
Janina Krell-Roesch, Leah P Cerhan, Mary M Machulda, Rosebud O Roberts, Michelle M Mielke, David S Knopman, Jeremy A Syrjanen, Teresa J Christianson, Ronald C Petersen, Yonas E Geda
No abstract text is available yet for this article.
August 13, 2018: Alzheimer Disease and Associated Disorders
Paola Gilsanz, Elizabeth Rose Mayeda, M Maria Glymour, Charles P Quesenberry, Dan Mungas, Charles S DeCarli, Rachel A Whitmer
IMPORTANCE: Birth in areas with high infant mortality rates (IMRs) has been linked to worse long-term health outcomes, yet it is completely unknown if it impacts dementia risk. METHODS: In total 6268 health care members were followed for dementia diagnosis from 1996 to 2015. Birth state IMRs from 1928 were ranked into quartile (worst IMRs quartile range, whites: 69 to 129 deaths/1000 live births, Non-whites: 129 to 277 deaths/1000 live births). Cox proportional hazard models estimated the dementia risk associated with birth state IMR quartile adjusting for demographics and lifecourse health indicators...
August 13, 2018: Alzheimer Disease and Associated Disorders
Madeleine Liljegren, Maria Landqvist Waldö, Robert Rydbeck, Elisabet Englund
OBJECTIVE: The aim of this study was to investigate and compare the prevalence and recurrence of police interaction (PI) with patients diagnosed with dementia. We also aimed to study the reason behind the PI, the time of occurrence of PI, and potential consequences of the PI. METHODS: For this retrospective medical records' review, we included 281 cases with a neuropathologic dementia diagnosis from the Department of Pathology, Region Skane/Lund University, between 1967 and 2013...
August 8, 2018: Alzheimer Disease and Associated Disorders
Madeline T Nguyen, Nora Mattek, Randy Woltjer, Diane Howieson, Lisa Silbert, Scott Hofer, Jeffrey Kaye, Hiroko Dodge, Deniz Erten-Lyons
BACKGROUND: Understanding contributions of different brain pathologies to domain-specific cognitive trajectories in the oldest old is crucial to guide future intervention studies. METHODS: Two-hundred-twenty Oregon Alzheimer's Disease Center research participants who were cognitively intact at entry were followed on average for 7.3 years with annual neuropsychological testing until death (mean age, 93.7 y) and autopsy. Mixed effects models examined the relationship between trajectories in memory, verbal fluency, and mini-mental state examination (MMSE) and pathology (neurofibrillary tangles, neuritic plaques, gross infarcts, hippocampal sclerosis, Lewy bodies, APOE genotype, age at death, and years of education)...
July 26, 2018: Alzheimer Disease and Associated Disorders
Xiuqin Jia, Lin Shi, Tianyi Qian, Ying Li, Defeng Wang, Peipeng Liang, Kuncheng Li
OBJECTIVE: This study aimed to test the hypothesis that the statistical Chinese brain template would be more effective to detect gray matter (GM) changes in patients with Alzheimer disease (AD) in Chinese populations. MATERIALS AND METHODS: In total, 50 patients with AD and 50 sex-matched and age-matched healthy controls were included in this study. Chinese2020, a typical statistical Chinese brain template, and MNI152, a typical Caucasian template were used for spatial normalization respectively...
July 17, 2018: Alzheimer Disease and Associated Disorders
George T Grossberg, Gustavo Alva, Suzanne Hendrix, Noel Ellison, Mary C Kane, John Edwards
Memantine extended release (ER) significantly outperformed placebo on co-primary endpoints of Clinician's Interview-based Impression of Change Plus Caregiver Input (CIBIC-Plus) and baseline to endpoint changes on the Severe Impairment Battery (SIB) in a 24-week, randomized trial (NCT00322153) in patients with moderate to severe Alzheimer's disease taking a cholinesterase inhibitor (ChEI). A post hoc analysis compared patients receiving memantine ER/ChEI to placebo/ChEI for time to onset of response and if the response was maintained (achieving improvement at weeks 8, 12, or 18 and maintaining through endpoint/week 24) on the SIB, the Neuropsychiatric Inventory (NPI), CIBIC-Plus, and Activities of Daily Living (ADL) using Fisher exact test...
July 2018: Alzheimer Disease and Associated Disorders
Nicholas I Bradfield, Kathryn A Ellis, Greg Savage, Paul Maruff, Samantha Burnham, David Darby, Nicola T Lautenschlager, Ralph N Martins, Colin L Masters, Stephanie R Rainey-Smith, Joanne Robertson, Christopher Rowe, Michael Woodward, David Ames
BACKGROUND: Given the long preclinical disease course of Alzheimer disease (AD) pathology, novel treatments may be more efficacious if administered before the emergence of dementia. Thus, accurate prediction of who will develop AD dementia is of key importance in selecting individuals for trials of treatment and may become crucial for future selection of patients for therapy. METHODS: As part of the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing, 901 individuals who did not have dementia were recruited...
July 2018: Alzheimer Disease and Associated Disorders
Julia Kim, Tom A Schweizer, Corinne E Fischer, David G Munoz
INTRODUCTION: Despite having severe Alzheimer disease pathology, some individuals remain cognitively asymptomatic (cASYM). To explore noncognitive manifestations in these cASYM individuals, we aim to investigate the prevalence and pathologic substrates of psychosis. METHODS: Data were obtained from the National Alzheimer's Coordinating Center. The Neuropsychiatric Inventory Questionnaire, quick version was used to evaluate presence of psychosis. Subjects with Mini-Mental Status Examination score of ≥24 with frequent neuritic plaques (NPs) were defined as NPcASYM, and those with Braak and Braak stage of neurofibrillary tangles of V/VI were defined as NTcASYM (both groups collectively designated cASYM)...
July 2018: Alzheimer Disease and Associated Disorders
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