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Alzheimer Disease and Associated Disorders

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https://www.readbyqxmd.com/read/29771687/memantine-er-maintains-patient-response-in-moderate-to-severe-alzheimer-s-disease-post-hoc-analyses-from-a-randomized-controlled-clinical-trial-of-patients-treated-with-cholinesterase-inhibitors
#1
George T Grossberg, Gustavo Alva, Suzanne Hendrix, Noel Ellison, Mary C Kane, John Edwards
Memantine extended release (ER) significantly outperformed placebo on co-primary endpoints of Clinician's Interview-based Impression of Change Plus Caregiver Input (CIBIC-Plus) and baseline to endpoint changes on the Severe Impairment Battery (SIB) in a 24-week, randomized trial (NCT00322153) in patients with moderate to severe Alzheimer's disease taking a cholinesterase inhibitor (ChEI). A post hoc analysis compared patients receiving memantine ER/ChEI to placebo/ChEI for time to onset of response and if the response was maintained (achieving improvement at weeks 8, 12, or 18 and maintaining through endpoint/week 24) on the SIB, the Neuropsychiatric Inventory (NPI), CIBIC-Plus, and Activities of Daily Living (ADL) using Fisher exact test...
May 16, 2018: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/29734264/the-accuracy-of-ineco-frontal-screening-in-the-diagnosis-of-executive-dysfunction-in-frontotemporal-dementia-and-alzheimer-disease
#2
Valéria S Bahia, Mário A Cecchini, Luciana Cassimiro, Rene Viana, Thais B Lima-Silva, Leonardo Cruz de Souza, Viviane Amaral Carvalho, Henrique C Guimarães, Paulo Caramelli, Márcio L F Balthazar, Benito Damasceno, Sônia M D Brucki, Ricardo Nitrini, Mônica S Yassuda
INTRODUCTION: Executive dysfunction is a common symptom in neurodegenerative disorders and is in need of easy-to-apply screening tools that might identify it. The aims of the present study were to examine some of the psychometric characteristics of the Brazilian version of the INECO frontal screening (IFS), and to investigate its accuracy to diagnose executive dysfunction in dementia and its accuracy to differentiate Alzheimer disease (AD) from the behavioral variant of frontotemporal dementia (bvFTD)...
May 4, 2018: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/29734263/medicare-expenditures-and-health-care-utilization-in-a-multiethnic-community-based-population-with-dementia-from-incidence-to-death
#3
Katherine A Ornstein, Carolyn W Zhu, Evan Bollens-Lund, Melissa D Aldridge, Howard Andrews, Nicole Schupf, Yaakov Stern
INTRODUCTION: While individuals live with dementia for many years, utilization and expenditures from disease onset through the end-of-life period have not been examined in ethnically diverse samples. METHODS: We used a multiethnic, population-based, prospective study of cognitive aging (Washington Heights-Inwood Columbia Aging Project) linked to Medicare claims to examine total Medicare expenditures and health care utilization among individuals with clinically diagnosed incident dementia from disease onset to death...
May 4, 2018: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/29734262/recruiting-the-oldest-old-for-clinical-research
#4
Zarui A Melikyan, Dana E Greenia, Maria M Corrada, Marilyn M Hester, Claudia H Kawas, Joshua D Grill
No abstract text is available yet for this article.
May 4, 2018: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/29698251/effects-of-the-tailored-activity-program-in-brazil-tap-br-for-persons-with-dementia-a-randomized-pilot-trial
#5
Marcia M P C Novelli, Styfany C B Machado, Gabriela B Lima, Lais Cantatore, Barbara P Sena, Renata S Rodrigues, Camila I B Rodrigues, Mariana B F Canon, Catherine V Piersol, Ricardo Nitrini, Monica S Yassuda, Laura N Gitlin
OBJECTIVES: The objectives of this study were to evaluate the effects of the Tailored Activity Program-Brazilian version (TAP-BR), on behavioral symptoms and the quality of life (QOL) in persons with dementia, as well as on their caregivers, and on caregiver burden. MATERIALS AND METHODS: A 2-group randomized controlled trial with 30 dyads was conducted: the experimental group (n=15) received TAP-BR over 4 months, and a wait-list control group (n=15) received usual care...
April 25, 2018: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/29683808/participant-satisfaction-with-learning-alzheimer-disease-clinical-trial-results
#6
Aimee L Pierce, Chelsea G Cox, Huong Nguyen, Dan Hoang, Megan Witbracht, Daniel L Gillen, Joshua D Grill
No abstract text is available yet for this article.
April 20, 2018: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/29561277/baseline-amnestic-severity-predicts-progression-from-amnestic-mild-cognitive-impairment-to-alzheimer-disease-dementia-at-3-years
#7
Nicholas I Bradfield, Kathryn A Ellis, Greg Savage, Paul Maruff, Samantha Burnham, David Darby, Nicola T Lautenschlager, Ralph N Martins, Colin L Masters, Stephanie R Rainey-Smith, Joanne Robertson, Christopher Rowe, Michael Woodward, David Ames
BACKGROUND: Given the long preclinical disease course of Alzheimer disease (AD) pathology, novel treatments may be more efficacious if administered before the emergence of dementia. Thus, accurate prediction of who will develop AD dementia is of key importance in selecting individuals for trials of treatment and may become crucial for future selection of patients for therapy. METHODS: As part of the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing, 901 individuals who did not have dementia were recruited...
March 20, 2018: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/29553944/psychosis-in-cognitively-asymptomatic-elderly-subjects-is-associated-with-neuritic-plaque-load-not-neurofibrillary-tangles
#8
Julia Kim, Tom A Schweizer, Corinne E Fischer, David G Munoz
INTRODUCTION: Despite having severe Alzheimer disease pathology, some individuals remain cognitively asymptomatic (cASYM). To explore noncognitive manifestations in these cASYM individuals, we aim to investigate the prevalence and pathologic substrates of psychosis. METHODS: Data were obtained from the National Alzheimer's Coordinating Center. The Neuropsychiatric Inventory Questionnaire, quick version was used to evaluate presence of psychosis. Subjects with Mini-Mental Status Examination score of ≥24 with frequent neuritic plaques (NPs) were defined as NPcASYM, and those with Braak and Braak stage of neurofibrillary tangles of V/VI were defined as NTcASYM (both groups collectively designated cASYM)...
March 16, 2018: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/29543605/thank-you-2017-reviewers
#9
(no author information available yet)
No abstract text is available yet for this article.
March 14, 2018: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/29543604/early-midlife-pulmonary-function-and-dementia-risk
#10
Paola Gilsanz, Elizabeth Rose Mayeda, Jason Flatt, M Maria Glymour, Charles P Quesenberry, Rachel A Whitmer
BACKGROUND: Poor pulmonary function (PPF) is associated with increased risk of dementia, yet it is unclear if PPF in early adulthood to midlife increases risk, independent of smoking and subsequent vascular disease. OBJECTIVE: This study evaluated the association between multiple markers of PPF in early adulthood to midlife and long-term risk of dementia. METHODS: We evaluated 27,387 members of an integrated health care system with forced expiratory volume in 1, 2 seconds, and vital capacity collected from 1964 to 1973 (mean age=41...
March 14, 2018: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/29528856/when-decrease-a%C3%AE-1-42-in-csf-may-not-mean-alzheimer-s-disease-insights-from-two-case-reports-with-early-onset-dementia
#11
Filipa Ladeira, Gonçalo Cação, Ana P Correia, Pedro S Pinto, Sara Cavaco, Manuel Melo-Pires, Isabel Alonso, Ricardo Taipa
No abstract text is available yet for this article.
March 9, 2018: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/29528855/dementia-prevalence-in-greece-the-hellenic-longitudinal-investigation-of-aging-and-diet-heliad
#12
Mary H Kosmidis, George S Vlachos, Costas A Anastasiou, Mary Yannakoulia, Efthimios Dardiotis, Georgios Hadjigeorgiou, Paraskevi Sakka, Eva Ntanasi, Nikolaos Scarmeas
INTRODUCTION: Study of the epidemiology of dementia to gain insight into putative predisposing and prophylactic factors is the first step toward establishing effective preventive and therapeutic strategies for this ever-growing public health problem. Relevant data in Greece are scattered and outdated. METHODS: We investigated dementia prevalence as part of a population-representative epidemiological study [Hellenic Longitudinal Investigation of Aging and Diet (HELIAD)] in 2 Greek regions...
March 9, 2018: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/29702488/self-awareness-of-driving-ability-in-the-healthy-elderly-and-patients-with-mild-cognitive-impairment-mci
#13
Stella Fragkiadaki, Ion N Beratis, Dionysia Kontaxopoulou, Dimosthenis Pavlou, Nikolaos Andronas, Andrew Papanicolaou, Alexandra Economou, George Yannis, Sokratis G Papageorgiou
INTRODUCTION: According to latest research, a percentage of cognitively impaired drivers fail to recognize their areas of weakness and overestimate their driving abilities. METHODS: Twenty-seven individuals with amnestic mild cognitive impairment (MCI) and 26 healthy elderly drivers participated in a driving simulator study. After the driving assessment, participants were asked to self-evaluate their performance in comparison with what they considered as average for people of similar age and educational level...
April 2018: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/29578861/alzheimer-disease-biomarkers-and-driving-in-clinically-normal-older-adults-role-of-spatial-navigation-abilities
#14
Samantha Allison, Ganesh M Babulal, Sarah H Stout, Peggy P Barco, David B Carr, Anne M Fagan, John C Morris, Catherine M Roe, Denise Head
PURPOSE: Older adults experience impaired driving performance, and modify their driving habits, including limiting amount and spatial extent of travel. Alzheimer disease (AD)-related pathology, as well as spatial navigation difficulties, may influence driving performance and driving behaviors in clinically normal older adults. We examined whether AD biomarkers [cerebrospinal fluid (CSF) concentrations of Aβ42, tau, and ptau181] were associated with lower self-reported spatial navigation abilities, and whether navigation abilities mediated the relationship of AD biomarkers with driving performance and extent...
April 2018: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/29351091/circadian-rhythms-disturbances-in-alzheimer-disease-current-concepts-diagnosis-and-management
#15
Ángela Milán-Tomás, Colin M Shapiro
The purpose of this review is to provide an overview of the research regarding circadian rhythms in Alzheimer disease (AD). Furthermore, this paper explores the role of melatonin in the pathogenesis of AD and the limitation of trials addressing circadian rhythms disturbances in the AD population. A literature search using Medline with PubMed and Embase was carried out identifying papers focusing on circadian rhythms in AD. Sleep disorders and especially circadian rhythm disturbances are very common in the elderly population but definitely more pronounced in patients with AD...
April 2018: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/29319601/the-moca-memory-index-score-an-efficient-alternative-to-paragraph-recall-for-the-detection-of-amnestic-mild-cognitive-impairment
#16
Antarpreet Kaur, Steven D Edland, Guerry M Peavy
OBJECTIVE: To compare ability of 2 measures of delayed memory (word list, story paragraph) to discriminate Normal Control (NC) subjects from those with amnestic mild cognitive impairment (aMCI). METHODS: Demographic, neuropsychological, and diagnostic data contributed by 34 Alzheimer's Disease Centers to the National Alzheimer's Coordinating Center characterized 2717 individuals with a diagnosis of either NC (n=2205) or aMCI (n=512). The Montreal Cognitive Assessment-Memory Index Score (MoCA-MIS) assessed delayed word recall, and the Craft Story 21, delayed story recall...
April 2018: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/29261520/inferior-parietal-cortex-hypoperfusion-is-the-most-specific-imaging-marker-for-ad-patients-with-positive-csf-biomarker-assays-in-a-memory-clinic-in-france
#17
Daniela Andriuta, Véronique Moullart, Susanna Schraen, Agnes Devendeville, Marc-Etienne Meyer, Olivier Godefroy
The diagnostic accuracy of hexamethylpropyleneamine oxime (HMPAo) single-photon emission computed tomography (SPECT) in Alzheimer disease (AD) remains undetermined in a "real-life" clinical population. The objective was to determine the HMPAo SPECT hypoperfusion pattern in cognitively impaired patients with positive CSF AD biomarker and to evaluate its diagnostic accuracy. This study included 120 patients referred to a university memory clinic assessed using HMPAo SPECT, MRI, and CSF biomarkers. Three biomarker signatures suggestive of AD were analyzed (1, Aß1-42; 2, Aß1-42+t-tau and/or p-tau; 3, Aß1-42/p-tau)...
April 2018: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/29189302/sex-differences-in-neuropsychological-test-performance-in-alzheimer-s-disease-and-the-influence-of-the-apoe-genotype
#18
Maria Tensil, Johannes B Hessler, Maria Gutsmiedl, Lina Riedl, Timo Grimmer, Janine Diehl-Schmid
BACKGROUND: Only few studies exist reporting sex differences in the Alzheimer disease (AD) patients regarding cognitive profile, brain damage, and risk factors. The present study investigated the influence of sex in combination with the Alzheimer risk allele, ε4-allele of apolipoprotein E, on cognitive performance. MATERIALS AND METHODS: We examined the effect of sex and ApoE genotype on a range of neuropsychological markers from the German version of the Consortium to Establish a Registry in Alzheimer's Disease Neuropsychological Battery in a monocentric study of 399 AD patients...
April 2018: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/29140858/computerized-cognitive-testing-in-primary-care-a-qualitative-study
#19
Geneva Millett, Gary Naglie, Ross Upshur, Liisa Jaakkimainen, Jocelyn Charles, Mary C Tierney
Computerized cognitive assessment tools may facilitate early identification of dementia in the primary care setting. We investigated primary care physicians' (PCPs') views on advantages and disadvantages of computerized testing based on their experience with the Computer Assessment of Mild Cognitive Impairment (CAMCI). Over a 2-month period, 259 patients, 65 years and older, from the family practice of 13 PCPs completed the CAMCI. Twelve PCPs participated in an individual interview. Generally, PCPs felt that the relationship between them and their patients helped facilitate cognitive testing; however, they thought available paper tests were time consuming and not sufficiently informative...
April 2018: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/29140857/that-s-inappropriate-social-norms-in-an-older-population-based-cohort
#20
Mary Ganguli, Zhaowen Sun, Eric McDade, Beth Snitz, Tiffany Hughes, Erin Jacobsen, Chung-Chou H Chang
BACKGROUND: Social cognition is not routinely assessed in older adults. We report population-based normative data on the Social Norms Questionnaire (SNQ22) which asks individuals about the appropriateness of specific behaviors in hypothetical scenarios, errors being related either to breaking with norms or to over-adhering to perceived norms. Total SNQ scores represent the number of correct responses while subscale scores are error totals. METHODS: We administered the SNQ22 to 744 adults aged 65+ within a population-based study, and examined the distribution of scores by demographics, other cognitive measures, and Clinical Dementia Rating (CDR)...
April 2018: Alzheimer Disease and Associated Disorders
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