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Journal of Clinical Pharmacy and Therapeutics

Hyung-Sook Kim, Eunsook Lee, Young-Jae Cho, Yeon Joo Lee, Sandy Jeong Rhie
WHAT IS KNOWN AND OBJECTIVE: Linezolid-induced thrombocytopenia is one of the many confounding conditions in critically ill patients. It is rare but prognostic importance of linezolid-induced thrombocytopenia in ICU population has not been well investigated. The study is to assess the incidence and risk factors of linezolid-induced thrombocytopenia in ICU patients. METHODS: We conducted a retrospective study with ICU patients treated with linezolid between January 2005 and December 2015 at the adult medical, surgical, emergency, and neurological ICUs at 1500-bed tertiary university medical center...
September 22, 2018: Journal of Clinical Pharmacy and Therapeutics
Zheng Xiao, Chengqiong Wang, Zhouke Tan, Shanshan Hu, Yali Chen, Minghua Zhou, Jihong Feng, Shiyu Liu, Ling Chen, Jie Ding, Qihai Gong, Fushan Tang, Hui Liu, Xiaofei Li
WHAT IS KNOWN AND OBJECTIVE: Sodium cantharidinate has been widely used in lung cancer treatment in China. To investigate whether sodium cantharidinate improves clinical effectiveness in non-small-cell lung cancer, we systematically re-evaluated all related studies. METHODS: All studies of cantharidinate for non-small-cell lung cancers (NSCLC) were selected from the MEDLINE, EMBASE, Web of Science (ISI), China National Knowledge Infrastructure Database (CNKI), Chinese Scientific Journals Full-Text Database (VIP), Wanfang, China Biological Medicine Database (CBM), Cochrane Central Register of Controlled Trials (CENTRAL), Chinese clinical trial registry (Chi-CTR), WHO International Clinical Trials Registry Platform (WHO-ICTRP) and US-clinical trials databases (established to September 2017)...
September 19, 2018: Journal of Clinical Pharmacy and Therapeutics
Lairun Jin, Jun Zhou, Wei Shi, Liang Xu, Jun Sheng, Jingyi Fan, Yuting Yuan, Hui Yuan
WHAT IS KNOWN AND OBJECTIVE: Previous studies have shown that various aspirin combinations might be beneficial for the treatment of acute cerebral infarction (ACI). The aim of this study was to evaluate the efficacy of six aspirin combinations in the treatment of ACI using network meta-analysis (NMA). The performance of these combinations is then ranked according to results of this analysis. METHODS: Multiple databases were consulted to find randomized controlled trials (RCT) of six different aspirin combinations for the treatment of ACI...
September 17, 2018: Journal of Clinical Pharmacy and Therapeutics
Rashmi R Shah, Peter D Stonier
WHAT IS KNOWN AND OBJECTIVE: In order to expedite the availability of drugs to treat cancers in a cost-effective manner, repurposing of old drugs for oncological indications is gathering momentum. Revolutionary advances in pharmacology and genomics have demonstrated many old drugs to have activity at novel antioncogenic pharmacological targets. We decided to investigate whether prospective studies support the promises of nonclinical and retrospective clinical studies on repurposing three old drugs, namely metformin, valproate and astemizole...
September 15, 2018: Journal of Clinical Pharmacy and Therapeutics
Andrew Thompson, Christine Randall, Justine Howard, Catrin Barker, Debbie Bowden, Paul Mooney, Agatha Munyika, Susan Smith, Munir Pirmohamed
WHAT IS KNOWN AND OBJECTIVE: Adverse drug reaction reporting in the UK is lower than expected based on epidemiological data. This study aims to explore (a) nonmedical prescribers' (NMP) confidence in identifying and reporting ADRs, (b) NMP prescribing habits and engagement with the Yellow Card Scheme (YCS) and (c) NMP desire for future training in the identification and reporting of ADRs. METHODS: A survey was distributed across NMP networks in the north-west of England using Survey Monkey...
September 11, 2018: Journal of Clinical Pharmacy and Therapeutics
Linda Hartman, Willem F Lems, Maarten Boers
WHAT IS KNOWN: Currently, medication bottles with an electronic cap are frequently used to measure medication adherence. This system is termed medication event monitoring system (MEMS). To our knowledge, the optimal method to summarize data from MEMS has not yet been determined. OBJECTIVE: Look for best practices on how to quantify adherence data from MEMS. METHODS: Review of PubMed, Embase and Cochrane databases for the articles on medication adherence with MEMS...
September 1, 2018: Journal of Clinical Pharmacy and Therapeutics
Robert B Raffa, Joseph V Pergolizzi, Robert Taylor, Michael H Ossipov
WHAT IS KNOWN AND OBJECTIVE: The double-helical conformation of human DNA (hDNA) is so axiomatic that it is called the "canonical" form. Recently, though, intrastrand folds ("I-motifs" and "G-quadruplexes") have been identified in hDNA. These could be targets for novel drug discovery. COMMENT: Any interruption of the canonical form of hDNA fundamentally impacts the normal progression of transduction and translation. In particular, the synthesis of receptors and cognate protein ligands would be affected, as well as their affinity for-and signal transduction of-pharmacotherapeutic agents...
August 25, 2018: Journal of Clinical Pharmacy and Therapeutics
Takuya Imatoh, Kimie Sai, Mayu Takeyama, Katsuhito Hori, Masato Karayama, Kazuki Furuhashi, Katsunori Segawa, Michio Kimura, Junichi Kawakami, Yoshiro Saito
WHAT IS KNOWN AND OBJECTIVE: This study used electronic medical records to identify risk factors and establish a detection algorithm for denosumab-induced hypocalcaemia. METHODS: We identified 201 patients with cancer who were initially prescribed denosumab. Hypocalcaemia was defined as an adjusted serum calcium level of ≤2.13 mmol/L. A diagnosis of denosumab-induced hypocalcaemia was confirmed by two physicians after reviewing patient medical records. We evaluated patient characteristics as potential screening factors...
August 24, 2018: Journal of Clinical Pharmacy and Therapeutics
Khac-Dung Nguyen, Thuy-Ngan Tran, Mai-Loan T Nguyen, Hoang-Anh Nguyen, Hoang-Anh Nguyen, Dinh-Hoa Vu, Van-Doan Nguyen, Haleh Bagheri
WHAT IS KNOWN AND OBJECTIVE: Despite the numerous studies investigating drug-induced Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN), the understanding and quantitative data in developing countries remain limited. The study aimed to describe and quantify the drug-related risk of SJS/TEN in a resource-limited context using the Vietnamese spontaneous reporting database (VSRD) of adverse drug reactions. METHODS: Spontaneous reports relating to medium- and late-onset severe cutaneous adverse reactions (MLOSCAR) and SJS/TEN recorded in the VSRD from 2010 to 2015 were retrospectively analysed...
August 20, 2018: Journal of Clinical Pharmacy and Therapeutics
Christo Cimino, Amanda Binkley, Regina Swisher, William R Short
WHAT IS KNOWN AND OBJECTIVE: With the advent of antiretroviral therapy and the resultant decrease in mortality among adults living with human immunodeficiency virus (HIV), there is now an increased incidence of obesity and obesity-related comorbidities in these patients. Bariatric surgery is becoming an increasingly common treatment option for patients who are classified as clinically obese. There are limited data regarding the use of antiretroviral therapy in patients who have undergone bariatric surgery...
August 15, 2018: Journal of Clinical Pharmacy and Therapeutics
Diogo Mendes, Carlos Alves, Márcia Loureiro, Ana Fonte, Francisco Batel-Marques
WHAT IS KNOWN AND OBJECTIVE: Hypersensitivity adverse drug reactions (HADRs) are associated with considerable morbidity and mortality. The aim of this study was to identify cases of HADRs within a hospital electronic health records (EHR) database. METHODS: Data were extracted from EHR through the Portuguese catalogue of allergies and other adverse reactions (CPARA). This registry allows the collection and sharing of information on HADRs in a structured and harmonized way across the healthcare system...
August 1, 2018: Journal of Clinical Pharmacy and Therapeutics
Gregory M Peterson, Jackson Thomas, Kwang C Yee, Sam Kosari, Mark Naunton, Inger H Olesen
WHAT IS KNOWN AND OBJECTIVE: It is 20 years since the US Food and Drug Administration approved the first successful monoclonal anticancer antibody, trastuzumab. The therapeutic utility of monoclonal antibodies in cancer is often limited by partial clinical responses and the development of tumour resistance. An expanding strategy, to be reviewed here, to overcome the limited response and resistance to monotherapy utilizes concurrent treatment with two synergistic monoclonal antibodies...
July 25, 2018: Journal of Clinical Pharmacy and Therapeutics
S Marin, L Campins, M Miarons, L Pérez-Cordón, C Reina-Aguilar, M Solsona
WHAT IS KNOWN AND OBJECTIVE: Beta-lactam antibiotic (BLA) therapy is frequently needed to treat infective endocarditis (IE). Hypersensitive reactions to BLA restrict BLA therapy in allergic patients. In the current case, we aim to describe the utility of desensitization (DS) in this context. Although the evidence is limited, DS is recommended. CASE DESCRIPTION: This case report deals with a 79-year-old woman with a clinical suspicion of allergy to BLA and a methicillin-sensitive Staphylococcus aureus (MSSA) IE...
July 21, 2018: Journal of Clinical Pharmacy and Therapeutics
Mylène Chartrand, Lyne Lalonde, Ariane Cantin, Alexandre Lahaie, Bojan Odobasic, Marie-Philip Tremblay, Dana Wazzan, Marie-Mireille Gagnon, Élisabeth Martin, Marc Dorais, Djamal Berbiche, Line Guénette
WHAT IS KNOWN AND OBJECTIVE: The literature has reported suboptimal real-world use of oral anticoagulants in patients with atrial fibrillation (AF). Anticoagulation management services (AMSs) in community pharmacy have rarely been evaluated, and no formal process is available to enable pharmacists to evaluate and improve their clinical practices. Our objective was to assess the feasibility of implementing, through a practice-based research network (PBRN), a quality improvement programme on AMSs by community pharmacists for AF patients and explore its impact on the quality of clinical practices and pharmacists' knowledge...
July 17, 2018: Journal of Clinical Pharmacy and Therapeutics
Junichi Kusano, Sachiko Tanaka, Hiroto Matsuda, Yoshikazu Hara, Yoshiaki Fujii, Shinya Suzuki, Masao Sekiyama, Eiki Ando, Kentaro Sugiyama, Toshihiko Hirano
WHAT IS KNOWN AND OBJECTIVE: Renal transplant recipients receive immunosuppressive therapy to prevent acute rejection. We evaluated the immunopharmacological efficacy of vitamin K1 (VK1) and vitamin K2 (VK2) on T-cell mitogen-activated-peripheral lymphocytes of dialysis patients and healthy subjects. METHODS: The effects of VK1 and VK2 on the T-cell mitogen-stimulated proliferation of peripheral blood mononuclear cells (PBMCs) obtained from 12 healthy subjects and 12 dialysis patients were estimated...
July 16, 2018: Journal of Clinical Pharmacy and Therapeutics
Keiko Hosohata, Ayaka Inada, Saki Oyama, Daisuke Furushima, Hiroshi Yamada, Kazunori Iwanaga
WHAT IS KNOWN AND OBJECTIVE: Acute kidney injury (AKI) often occurs in hospitalized patients, and it is an increasing problem worldwide. Recently, clinical studies have shown that there is a strong association between drug-induced AKI and poor outcomes, including the progression of chronic kidney disease and end-stage renal disease; however, limited data are available on drug-induced AKI. The purpose of this study was to clarify the rank-order of the association of all drugs with AKI using a spontaneous reporting system database...
July 16, 2018: Journal of Clinical Pharmacy and Therapeutics
Maurizio Sessa, Francesca Futura Bernardi, Andrea Vitale, Beniamino Schiavone, Giulia Gritti, Annamaria Mascolo, Michele Bertini, Cristina Scavone, Liberata Sportiello, Francesco Rossi, Annalisa Capuano
WHAT IS KNOWN AND OBJECTIVE: Medication errors, such as unnecessary treatment discontinuation during treatment with direct-acting antivirals (DAAs), can lead to imbalances in the benefit-to-risk ratio. This risk is especially high when the medication error leads to adverse drug reactions (ADRs). However, to date, evidence on the frequency of this phenomenon is scarce. This study aims to provide better insight into ADRs possibly due to medication errors leading to DAA discontinuation and their preventability...
July 16, 2018: Journal of Clinical Pharmacy and Therapeutics
Zhao-Qi Tang, Rui-Hua Jiang, Hong-Bin Xu
WHAT IS KNOWN AND OBJECTIVE: In this study, the effectiveness of pharmaceutical care on treatment outcomes for patients with first-time pulmonary tuberculosis in China was assessed. METHODS: In this study, patients were randomized either to the usual care (UC) group (n = 72) where patients received routine medical and nursing care or to the pharmaceutical care (PC) group (n = 59) where patients were simultaneously provided with pharmaceutical care. The primary objectives were to evaluate whether treatment outcomes and patient adherence improved more in the PC group than in the UC group...
July 12, 2018: Journal of Clinical Pharmacy and Therapeutics
A-L Blanc, B Guignard, A Desnoyer, O Grosgurin, C Marti, C Samer, P Bonnabry
WHAT IS KNOWN: Potentially inappropriate medication (PIM) is a risk factor for drug-related problems (DRPs) and an important inpatient safety issue. PIM-Check is a screening tool designed to detect PIM in internal medicine patients. OBJECTIVE: This study aimed to determine whether PIM-Check could help to identify and reduce DRPs. METHOD: Prospective interventional study conducted on patients admitted to internal medicine wards in a university hospital between 1 September 2015 and 30 October 2015...
July 5, 2018: Journal of Clinical Pharmacy and Therapeutics
Satoko Oka, Kazuo Ono, Masaharu Nohgawa
WHAT IS KNOWN AND OBJECTIVES: Optimal strategies for treating patients with very advanced relapsed and refractory multiple myeloma (RRMM) have not been clarified. CASE SUMMARY: A 80-year-old patient with RRMM experienced extramedullary relapse following treatment with bortezomib, lenalidomide and pomalidomide. However, he achieved very good partial remission after retreatment with lenalidomide. WHAT IS NEW AND CONCLUSION: This report illustrates that patients with very advanced RRMM can still respond to prior therapy even after being exposed and refractory to several agents...
July 4, 2018: Journal of Clinical Pharmacy and Therapeutics
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