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Journal of Clinical Pharmacy and Therapeutics

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https://www.readbyqxmd.com/read/28191663/a-case-of-lupus-like-syndrome-in-a-patient-receiving-adalimumab-and-a-brief-review-of-the-literature-on-drug-induced-lupus-erythematosus
#1
I Lomicová, D Suchý, K Pizinger, P Cetkovská
WHAT IS KNOWN AND OBJECTIVE: Drug-induced lupus erythematosus occurs with some drugs and resolves with their withdrawal. Anti-TNF therapies have been found to be associated with a lupus-like syndrome, which is clinically distinct from classical drug-induced as well as idiopathic lupus erythematosus. CASE DESCRIPTION: We describe a case of a patient with severe psoriasis, who developed muscle pain with paraesthesia accompanied by ANA titres elevation with adalimumab treatment...
February 12, 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/28191662/cannabidiol-an-alternative-therapeutic-agent-for-oral-mucositis
#2
REVIEW
L F Cuba, F G Salum, K Cherubini, M A Z Figueiredo
WHAT IS KNOWN AND OBJECTIVE: Chemo- and radiotherapy are therapeutic modalities often used in patients with malignant neoplasms. They kill tumour cells but act on healthy tissues as well, resulting in adverse effects. Oral mucositis is especially of concern, due to the morbidity that it causes. We reviewed the literature on the etiopathogenesis of oral mucositis and the activity of cannabidiol, to consider the possibility of its use for the prevention and treatment of oral mucositis. METHODS: We searched the PubMed database and selected complete articles published in English that met the inclusion criteria for the period 1998-2016...
February 12, 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/28177134/the-influence-of-combination-use-of-cyp450-inducers-on-the-pharmacokinetics-of-voriconazole-a-systematic-review
#3
REVIEW
T-Y Li, W Liu, K Chen, S-Y Liang, F Liu
WHAT IS KNOWN AND OBJECTIVES: Voriconazole is a triazole antifungal agent and is extensively metabolized via cytochrome P450 (CYP450); therefore, special precautions need to be taken when co-administered with a known CYP450 inducer, which may lead to treatment failure. The influence of some CYP450 inducers on the pharmacokinetics of voriconazole has been described in previous studies, but a systematic review was lacking. In this study, we carried out a systematic review to assess the influence of CYP450 inducers on the pharmacokinetic (PK) parameters of voriconazole...
February 8, 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/28164359/off-label-drug-use-in-oncology-a-systematic-review-of-literature
#4
REVIEW
M M Saiyed, P S Ong, L Chew
WHAT IS KNOWN AND OBJECTIVE: The off-label use of medicines is widespread in several diseases. This type of prescribing practice is particularly more acute in oncology. However, the suitability of anticancer medications for off-label use remains an issue of controversy, due to uncertainty around the clinical benefits and potential toxicities, limited evidence to support clinical decision-making, increased out-of-pocket costs for patients and ethical concerns around the lack of informed consent...
February 5, 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/28155237/the-use-of-potentially-inappropriate-medications-among-the-lithuanian-elderly-according-to-beers-and-eu-7-pim-list-a-nationwide-cross-sectional-study-on-reimbursement-claims-data
#5
D Grina, V Briedis
WHAT IS KNOWN AND OBJECTIVE: The prevalence and risk factors for prescribing and using potentially inappropriate medications (PIMs) has been extensively researched in Western Europe and the United States of America; however, research in Central and Eastern Europe remains highly limited. According to a recent systematic review, the overall estimated weighted prevalence of PIM prescribing in community-dwelling elderly in Europe (expressed as a percentage of patients or prescriptions with ≥1 PIM) was 22·6% (95% CI: 19·5%-26·7%)...
February 2, 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/28145574/drug-drug-interaction-between-valproic-acid-and-meropenem-a-retrospective-analysis-of-electronic-medical-records-from-neurosurgery-inpatients
#6
Z-P Wen, S-S Fan, C Du, T Yin, B-T Zhou, Z-F Peng, Y-Y Xie, W Zhang, Y Chen, J Xiao, X-P Chen
WHAT IS KNOWN AND OBJECTIVE: A series of studies have indicated that valproic acid (VPA) plasma concentration decreased rapidly when used concomitantly with carbapenem antibiotics, including meropenem (MEPM), imipenem and panipenem, which may increase the risk of seizure breakthrough. However, the cause for the change in VPA pharmacokinetics is unclear. A retrospective analysis of VPA therapeutic drug monitoring (TDM) records was performed to investigate this VPA pharmacokinetics drug-drug interaction...
February 1, 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/28144968/adverse-event-due-to-a-likely-interaction-between-sodium-aescinate-and-ginkgo-biloba-extract-a-case-report
#7
H Ji, G Zhang, F Yue, X Zhou
WHAT IS KNOWN AND OBJECTIVE: Drug-induced nephrotoxicity is potentially lethal. When sodium aescinate is given to surgical inpatients to treat postoperative inflammation and oedema, adverse drug reactions and drug-drug interactions must be closely monitored. CASE DESCRIPTION: We report a case of a 58-year-old man with phalangeal fractures who suffered from acute kidney injury that was most likely induced by the drug interaction between sodium aescinate and ginkgo biloba extract due to the protein-binding and metabolic characteristics of these drugs...
February 1, 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/28120520/chemoradiation-combined-with-regional-hyperthermia-for-advanced-oesophageal-cancer-a-systematic-review-and-meta-analysis
#8
REVIEW
Y Hu, Z Li, D-H Mi, N Cao, S-W Zu, Z-Z Wen, X-L Yu, Y Qu
WHAT IS KNOWN AND OBJECTIVE: Hyperthermia is an effective treatment modality that augments the anticancer effects of radiotherapy and chemotherapy. Hyperthermia-chemo-radiotherapy (HCRT) is a combination therapy that can strengthen anticancer effects through a synergistic interaction between heat, chemotherapy and radiation. Here, we carried out a systematic review and meta-analysis to evaluate the clinical efficacy and safety of chemoradiation combined with regional hyperthermia (HCRT) for oesophageal carcinoma...
January 25, 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/28111765/potential-drug-drug-and-drug-disease-interactions-in-well-functioning-community-dwelling-older-adults
#9
J T Hanlon, S Perera, A B Newman, J M Thorpe, J M Donohue, E M Simonsick, R I Shorr, D C Bauer, Z A Marcum
WHAT IS KNOWN AND OBJECTIVE: There are few studies examining both drug-drug and drug-disease interactions in older adults. Therefore, the objective of this study was to describe the prevalence of potential drug-drug and drug-disease interactions and associated factors in community-dwelling older adults. METHODS: This cross-sectional study included 3055 adults aged 70-79 without mobility limitations at their baseline visit in the Health Aging and Body Composition Study conducted in the communities of Pittsburgh PA and Memphis TN, USA...
January 22, 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/28111761/what-is-the-mechanism-of-ketamine-s-rapid-onset-antidepressant-effect-a-concise-overview-of-the-surprisingly-large-number-of-possibilities
#10
REVIEW
S E Strasburger, P M Bhimani, J H Kaabe, J T Krysiak, D L Nanchanatt, T N Nguyen, K A Pough, T A Prince, N S Ramsey, K H Savsani, L Scandlen, M J Cavaretta, R B Raffa
WHAT IS KNOWN AND OBJECTIVE: Abundant clinical data now confirm that ketamine produces a remarkable rapid-onset antidepressant effect - hours or days - in contrast to the delayed onset (typically weeks) of current antidepressant drugs. This surprising and revolutionary finding may lead to the development of life-saving pharmacotherapy for depressive illness by reducing the high suicide risk associated with the delayed onset of effect of current drugs. As ketamine has serious self-limiting drawbacks that restrict its widespread use for this purpose, a safer alternative is needed...
January 22, 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/28097680/development-of-a-novel-algorithm-for-detecting-glucocorticoid-induced-diabetes-mellitus-using-a-medical-information-database
#11
T Imatoh, K Sai, K Hori, K Segawa, J Kawakami, M Kimura, Y Saito
WHAT IS KNOWN AND OBJECTIVE: Glucocorticoid-induced diabetes mellitus (GIDM) increases the risk of diabetes mellitus (DM)-related complications but is generally difficult to detect in clinical settings. The criteria for diagnosing GIDM have not been established. Recently, medical information databases (MIDs) have been used in post-marketing surveillance (PMS) studies. We conducted a pharmacoepidemiological study to develop an algorithm for detecting GIDM using MID. METHODS: We selected 1214 inpatients who were newly prescribed with a typical glucocorticoid, prednisolone, during hospitalization from 2008 to 2014 from an MID of Hamamatsu University Hospital in Japan...
January 18, 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/28078665/computerized-pharmacy-surveillance-and-alert-system-for-drug-related-problems
#12
O Ferrández, O Urbina, S Grau, J Mateu-de-Antonio, M Marin-Casino, J Portabella, S Mojal, M Riu, E Salas
WHAT IS KNOWN AND OBJECTIVE: Because of the impact of drug-related problems (DRPs) on morbidity and mortality, there is a need for computerized strategies to increase drug safety. The detection and identification of the causes of potential DRPs can be facilitated by the incorporation of a pharmacy warning system (PWS) in the computerized prescriber order entry (CPOE) and its application in the routine validation of inpatient drug therapy. A limited number of studies have evaluated a clinical decision support system to monitor drug treatment...
January 12, 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/28039932/potentially-inappropriate-medications-in-elderly-japanese-patients-effects-of-pharmacists-assessment-and-intervention-based-on-screening-tool-of-older-persons-potentially-inappropriate-prescriptions-criteria-ver-2
#13
T Kimura, F Ogura, K Yamamoto, A Uda, T Nishioka, M Kume, H Makimoto, I Yano, M Hirai
WHAT IS KNOWN AND OBJECTIVES: The Screening Tool of Older Persons' Potentially Inappropriate Prescriptions (stopp) criteria were updated in 2014 (stopp criteria ver.2), but few studies have evaluated the usefulness of stopp criteria in elderly patients. This prospective observational study evaluated the prevalence of potentially inappropriate medications (PIMs), and the efficacy of hospital pharmacists' assessment and intervention based on stopp criteria ver.2. METHODS: The study was conducted at three medical units of Kobe University Hospital between April 2015 and March 2016...
December 31, 2016: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/28004853/ustekinumab-therapy-for-crohn-s-disease-during-pregnancy-a-case-report-and-review-of-the-literature
#14
X Cortes, J Borrás-Blasco, B Antequera, S Fernandez-Martinez, E Casterá, S Martin, J R Molés
WHAT IS KNOWN AND OBJECTIVES: The safety of continued ustekinumab (UST) therapy during pregnancy remains unclear in patients with Crohn's disease (CD). There are no meta-analysis reports of exposure to UST during pregnancy. The objective was to describe a case of a pregnant patient with CD who was successfully treated with UST maintenance therapy throughout the pregnancy and delivered a baby boy without any congenital malformations, neurological abnormalities or birth defects. CASE SUMMARY: A 37-year-old patient with CD treated with UST became pregnant...
December 22, 2016: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/28000318/dawn-of-the-direct-acting-oral-anticoagulants-trends-in-oral-anticoagulant-prescribing-in-wales-2009-2015
#15
M B Protty, J Hayes
WHAT IS KNOWN AND OBJECTIVE: Oral anticoagulants (OACs) have been used for decades for the long-term prevention of arterial and venous thromboembolic disease. These include warfarin and the newer direct-acting OACs (DOACs). Data on 'real-life' prescribing patterns for DOACs are limited. In this commentary, we report the prescribing patterns for OACs in Wales, as a representative country within the UK. COMMENT: A retrospective analysis of anonymized OAC prescribing data in Wales from June 2009 to December 2015...
December 21, 2016: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/27981600/the-effect-of-pharmacists-on-ward-rounds-measured-by-the-stopp-start-tool-in-a-specialized-geriatric-unit
#16
K Mulvogue, J A Roberts, I Coombes, N Cottrell, S Kanagarajah, A Smith
WHAT IS KNOWN AND OBJECTIVE: The STOPP/START tool has been validated to assess elderly patients for potentially inappropriate prescribing. This study aimed to assess the effect of inclusion of a pharmacist on a physician-led ward round on potentially inappropriate prescribing in hospitalized elderly patients. METHODS: This was an observational study of prescribing for patients using the STOPP/START tool at three points during hospital stay; admission to hospital, on transfer to the specialized geriatric unit and on discharge from hospital...
December 16, 2016: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/27982453/trends-in-celecoxib-and-etoricoxib-prescribing-following-removal-of-prior-authorization-requirement-in-spain
#17
E Carracedo-Martínez, A Pia-Morandeira, A Figueiras
WHAT IS KNOWN AND OBJECTIVE: Previous studies indicate that the implementation of a prior authorization requirement for coxibs was followed by a sharp decline in their use. There are no studies showing what happens if coxib prior authorization is removed. The objective of this study is to assess the trend in the use of coxibs marketed in Spain, following removal of their respective prior authorization requirements in November 2006 for celecoxib and February 2007 for etoricoxib. METHODS: We calculated the monthly number of defined daily doses per thousand inhabitants per day (DDD/TID) of coxibs dispensed in a health area of Spain from mid-2005 to December 2007...
December 15, 2016: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/27957745/exploring-new-zealand-prescription-data-using-sequence-symmetry-analyses-for-predicting-adverse-drug-reactions
#18
P S Nishtala, T-Y Chyou
WHAT IS KNOWN AND OBJECTIVE: Prescription sequence symmetry analyses (PSSA) is a ubiquitous tool employed in pharmacoepidemiological research to predict adverse drug reactions (ADRs). Several studies have reported the advantage of PSSA as a method that can be applied to a large prescription database with computational ease. The objective of this study was to validate New Zealand (NZ) prescription database as a potential source for identifying ADRs using the PSSA method. METHODS: We analysed de-identified individual-level prescription data for people aged 65 years and above for the period 2005 to 2014 from the pharmaceutical collections supplied by the NZ Ministry of Health...
December 13, 2016: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/27943354/decade-long-temporal-trends-in-the-utilization-of-preventive-medicines-by-centenarians
#19
S W Narayan, P S Nishtala
WHAT IS KNOWN AND OBJECTIVE: Centenarians represent a population of individuals with delayed disability and are an ideal representation of ageing well; however, studies related to medicine use in this population are scarce. Our study aimed to explore the temporal trends associated with the utilization of preventive medicines in centenarians. METHODS: A repeated cross-sectional analysis was conducted from 1st January 2006 to 31st December 2015 for all individuals ≥100 years old on the date of dispensing, captured in New Zealand's pharmaceutical claims data set...
December 10, 2016: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/27943349/problems-with-continuity-of-care-identified-by-community-pharmacists-post-discharge
#20
H T Ensing, E S Koster, P I van Berkel, A A van Dooren, M L Bouvy
WHAT IS KNOWN AND OBJECTIVE: Medication discrepancies are common at hospital discharge, and medication reconciliation is widely endorsed as a preventive strategy. However, implementation is difficult for instance due to the unreliability of patients medication histories. In the Netherlands, community pharmacies are well-informed about their patients' pre-admission medication status which enables thorough post-discharge reconciliation. Our aim was to study the frequency and nature of medication discrepancies, missing patient's knowledge and administrative problems at admission to primary care...
December 10, 2016: Journal of Clinical Pharmacy and Therapeutics
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