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https://www.readbyqxmd.com/read/30401900/serial-tsh-receptor-antibody-levels-to-guide-the-management-of-thyroid-eye-disease-the-impact-of-smoking-immunosuppression-radio-iodine-and-thyroidectomy
#1
Jonathan C P Roos, Vignesh Paulpandian, Rachna Murthy
The Thyrotropin receptor antibody (TRAb) is the main driver of Graves' disease (GD) and its most common extra-thyroidal manifestation: thyroid eye disease (TED). Though key to diagnosis, it has not been used routinely as a marker of disease activity or to guide treatment. Here we demonstrate, through a retrospective review of 105 patients with TED, that serial TRAb levels vary with time, correlate with disease activity and are affected by smoking and endocrine control. Such serial measurements can guide the modern management of thyroid eye disease, helping to prevent the more serious manifestations...
November 6, 2018: Eye
https://www.readbyqxmd.com/read/30401899/fundus-photograph-based-deep-learning-algorithms-in-detecting-diabetic-retinopathy
#2
REVIEW
Rajiv Raman, Sangeetha Srinivasan, Sunny Virmani, Sobha Sivaprasad, Chetan Rao, Ramachandran Rajalakshmi
Remarkable advances in biomedical research have led to the generation of large amounts of data. Using artificial intelligence, it has become possible to extract meaningful information from large volumes of data, in a shorter frame of time, with very less human interference. In effect, convolutional neural networks (a deep learning method) have been taught to recognize pathological lesions from images. Diabetes has high morbidity, with millions of people who need to be screened for diabetic retinopathy (DR)...
November 6, 2018: Eye
https://www.readbyqxmd.com/read/30401898/time-dependent-changes-in-hypoxia-and-gliosis-related-factors-in-experimental-diabetic-retinopathy
#3
Limin Gu, Hua Xu, Chaoyang Zhang, Qian Yang, Limei Zhang, Jingfa Zhang
Diabetes causes various biochemical changes in the retina; long-term changes in the factors associated with hypoxia and gliosis have rarely been reported. The present study was conducted to explore the changes in these factors in a time-dependent manner in experimental diabetic retinopathy (DR). Diabetes was induced in Sprague-Dawley rats by intraperitoneal injection of streptozotocin. The expression of the following factors was examined using immunofluorescence and western blot analysis at 0.5, 1, 2, 4 and 6 months after diabetes onset: hypoxia-inducible factor-1alpha (HIF-1alpha), vascular endothelial growth factor (VEGF), erythropoietin (EPO), erythropoietin receptor (EPOR), glial fibrillary acidic protein (GFAP), vimentin, glutamate-aspartate transporter (GLAST) and glutamine synthase (GS)...
November 6, 2018: Eye
https://www.readbyqxmd.com/read/30397254/are-patients-with-ectopia-lentis-known-to-cardiology-services
#4
LETTER
P Maghsoudlou, T Khanam, P J Banerjee, A Chandra
No abstract text is available yet for this article.
November 5, 2018: Eye
https://www.readbyqxmd.com/read/30397253/consulting-the-consultants-avastin-in-the-treatment-of-wet-amd
#5
Ryian Mohamed, David C Saunders, John P Mathews
No abstract text is available yet for this article.
November 5, 2018: Eye
https://www.readbyqxmd.com/read/30390056/effect-of-phase-plate-adjustment-on-retinal-image-sharpness-and-visible-retinal-area-on-ultrawide-field-imaging
#6
Aditi Gupta, Hala El-Rami, Rasha Barham, Alan Fleming, Jano van Hemert, Jennifer K Sun, Paolo S Silva, Lloyd Paul Aiello
BACKGROUND: To evaluate changes in image sharpness across ultrawide field (UWF) images and the effect of phase-plate adjustment on image contrast and extent of visible retinal area (VRA). METHODS: This was a single site evaluation of 200° UWF images acquired with phase-plate adjustment (California, Optos, plc) and without (200TX, Optos, plc). Images were acquired using standardized protocol. VRA was manually outlined on each image and quantified using customized software...
November 2, 2018: Eye
https://www.readbyqxmd.com/read/30390055/sector-retinitis-pigmentosa-caused-by-mutations-of-the-rho-gene
#7
Ting Xiao, Ke Xu, Xiaohui Zhang, Yue Xie, Yang Li
BACKGROUND: Sector retinitis pigmentosa (RP) is an atypical form of RP in which only one or two quadrants of the retina are involved. The objectives of this study were to report the results of a molecular screening of five unrelated Chinese patients with sector RP and describe the clinical features observed in patients with RHO mutations. METHODS: Five probands that were clinically diagnosed with sector RP were recruited for genetic analysis. They underwent ophthalmic examinations, including best corrected visual acuity, fundus examination, visual field examinations, and electroretinography...
November 2, 2018: Eye
https://www.readbyqxmd.com/read/30390054/a-history-of-graves-and-st-john-s
#8
EDITORIAL
David L Williams
No abstract text is available yet for this article.
November 2, 2018: Eye
https://www.readbyqxmd.com/read/30390053/evolution-of-thyroid-eye-disease-decompression-dysthyroid-optic-neuropathy
#9
Andrea A Tooley, Kyle J Godfrey, Michael Kazim
Orbital decompression surgery and medical therapy for thyroid eye disease (TED) have evolved over the past 150 years and afforded the opportunity to restore pre-disease appearance and visual function. This manuscript explores the past 150 years of surgical innovation for the treatment of TED. The "Age of Surgical Heroism" spans the time from 1888 to 1979 during which the pioneers of orbital decompression developed lateral orbitotomy, transcranial decompression, paranasal sinus decompression, and transantral decompression despite an incomplete understanding of the pathophysiology of both TED and a limited ability to non-invasively assess their patients...
November 2, 2018: Eye
https://www.readbyqxmd.com/read/30390052/comment-on-association-of-chlamydia-trachomatis-ompa-genovar-with-trachoma-phenotypes
#10
LETTER
Hugh Taylor
No abstract text is available yet for this article.
November 2, 2018: Eye
https://www.readbyqxmd.com/read/30385883/the-insulin-like-growth-factor-i-receptor-and-its-role-in-thyroid-associated-ophthalmopathy
#11
Terry J Smith
BACKGROUND/OBJECTIVES: Thyroid-associated ophthalmopathy (TAO), an autoimmune component of Graves' disease, remains a disfiguring and potentially blinding condition. Here, the author reviews the role of insulin-like growth factor-I receptor pathway in TAO and how it might be therapeutically targeted. METHODS: The recent literature is reviewed. RESULTS: TAO involves reactivity of orbital connective tissues and their remodeling. While many of the details concerning the pathogenesis of TAO remain to be determined, several insights have come to light recently...
November 1, 2018: Eye
https://www.readbyqxmd.com/read/30385882/retinal-detachment-due-to-paravascular-abnormalities-associated-breaks-in-highly-myopic-eyes
#12
Yi-Ting Hsieh, Chung-May Yang
PURPOSE: To describe the characteristics of a novel type of retinal detachment (RD) due to paravascular abnormalities (PVAs) associated breaks in highly myopic eyes. METHODS: We retrospective recruited eight eyes with RD due to PVA-associated breaks. The clinical features and surgical results were evaluated. RESULTS: All eyes were highly myopic with a mean axial length of 31.31 ± 2.86 mm (27.51-36.52 mm). Two of the eight eyes had multiple paravascular retinal breaks associated with PVAs, four had a single paravascular break with PVAs nearby, and two had multiple paravascular breaks along the same vessels...
November 1, 2018: Eye
https://www.readbyqxmd.com/read/30385881/retinoblastoma-in-asia
#13
REVIEW
Mukesh Jain, Duangnate Rojanaporn, Bhavna Chawla, Gangadhar Sundar, Lingam Gopal, Vikas Khetan
Asia-Pacific region bears a significant global burden of retinoblastoma (RB), therefore understanding RB in Asia-Pacific region is important. Based on the year 2013 population estimates, 43% (3452 of 8099 children) of the global burden of RB lives in 6 countries of Asia-Pacific region: 1486 children in India, 1103 children in China, 277 children in Indonesia, 260 children in Pakistan, 184 children in Bangladesh, 142 children in Philippines. There exists a wide disparity, technological and socio-economical, within countries in this region resulting in a varied pattern of clinical presentation and survival varies...
November 1, 2018: Eye
https://www.readbyqxmd.com/read/30385880/optic-neuropathy-after-repair-of-rhegmatogenous-retinal-detachment
#14
LETTER
Jonathan I Huz, Tian Xia, Larry Frohman, Roger E Turbin, Neelakshi Bhagat
No abstract text is available yet for this article.
November 1, 2018: Eye
https://www.readbyqxmd.com/read/30385879/a-review-of-cosmetic-contact-lens-infections
#15
REVIEW
Chris H L Lim, Fiona Stapleton, Jodhbir S Mehta
This paper provides a comprehensive review of the existing literature surrounding cosmetic contact lens infections. In this paper, lens-related, dispensing-related and patient-related factors are examined in detail.
November 1, 2018: Eye
https://www.readbyqxmd.com/read/30385878/prevalence-of-optic-disc-haemorrhages-in-an-elderly-uk-caucasian-population-and-possible-association-with-reticular-pseudodrusen-the-bridlington-eye-assessment-project-beap-a-cross-sectional-study-2002-2006
#16
Craig Wilde, Ali Poostchi, Rajesh Narendran, Hamish K MacNab, Jonathan G Hillman, Phillip Alexander, Winfried M Amoaku, Stephen A Vernon
AIMS: To determine disc haemorrhage (DH) prevalence in an elderly UK population-the Bridlington Eye Assessment Project (BEAP). METHODS: Thirty-degree fundus photographs (3549 participants ≥65 years) were graded for DH/macula changes. Glaucoma evaluation included Goldmann tonometry, 26-point suprathreshold visual-fields and mydriatic slit-lamp assessment for glaucomatous optic neuropathy. RESULTS: In all, 3548 participants with photographs in at least one eye...
November 1, 2018: Eye
https://www.readbyqxmd.com/read/30382240/granular-lesions-of-short-wavelength-and-near-infrared-autofluorescence-in-diabetic-macular-oedema
#17
Shin Yoshitake, Tomoaki Murakami, Akihito Uji, Masahiro Fujimoto, Yoko Dodo, Kiyoshi Suzuma, Akitaka Tsujikawa
OBJECTIVES: To document and characterise hyper- and hypo-reflective lesions, which we describe as 'granular' on short-wavelength autofluorescence (SW-AF) and near-infrared (NIR)-AF images in diabetic macular oedema (DMO). METHODS: Consecutive 103 eyes of 78 patients suffering from centre-involving DMO were reviewed retrospectively. Mosaics of hyper- and hypo-fluorescent dots on both SW-AF and NIR-AF signals were delineated and defined as granular lesions in the macula...
October 31, 2018: Eye
https://www.readbyqxmd.com/read/30382239/ability-of-swept-source-oct-to-detect-retinal-changes-in-patients-with-bipolar-disorder
#18
Vicente Polo, Maria Satue, Alicia Gavin, Elisa Vilades, Elvira Orduna, Marta Cipres, Javier Garcia-Campayo, Mayte Navarro-Gil, Jose M Larrosa, Luis E Pablo, Elena Garcia-Martin
PURPOSE: To evaluate the ability of swept source optical coherence tomography (SS-OCT) to detect retinal changes in patients with bipolar disorder (BD). METHODS: Twenty-three patients with BD and 23 controls underwent retinal evaluation using SS deep range imaging (DRI) Triton OCT. Full retinal thickness, the ganglion cell layer (GCL), the retinal nerve fiber layer (RNFL), and choroidal thickness were evaluated with automated segmentation software. RESULTS: Patients with BD were shown to have significant thinning of the macular full retinal thickness in the center (p = 0...
October 31, 2018: Eye
https://www.readbyqxmd.com/read/30382238/cataract-extraction-after-deep-sclerectomy-and-its-effect-on-intraocular-pressure-control
#19
Karl Mercieca, Divya Perumal, Kieren Darcy, Nitin Anand
PURPOSE: To estimate the incidence and predisposing factors for cataract extraction (CE) after Deep Sclerectomy (DS) with Mitomycin-C (MMC) and its effect on intraocular pressure (IOP) control. METHODS: Retrospective study of phakic eyes which had DS with MMC performed over a 5-year period. 179 eyes of 179 patients were included. RESULTS: Mean age at time of DS was 68.6 ± 9.7 years and mean follow-up was 89.4 ± 29.4 months. 63 eyes had CE and the probability of CE following DS was 0% at 1, 11...
October 31, 2018: Eye
https://www.readbyqxmd.com/read/30382237/refractive-outcomes-of-cataract-surgery-in-primary-congenital-glaucoma
#20
Sudarshan Khokhar, Dev Yadav, Shikha Gupta, Ramanjit Sihota, Abadh Kishore Chaurasia, Amisha Gupta, Viney Gupta
AIM: To evaluate refractive outcomes of cataract surgery with intraocular lens (IOL) implantation in operated eyes of primary congenital glaucoma (PCG). DESIGN: A retrospective case-control study. METHODS: Patients of PCG who developed cataract following trabeculectomy with trabeculotomy were recruited. Preoperative biometry was recorded and refractive outcomes of the patients in terms of spherical equivalent (SE) and prediction error were noted at 3 and at 12 months following surgery...
October 31, 2018: Eye
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