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Olachi J Mezu-Ndubuisi, Thao Adams, Lauren K Taylor, Adaure Nwaba, Jens Eickhoff
BACKGROUND: Retinopathy of prematurity is a condition of abnormal retinal vascularization in premature infants. The effect of abnormal vascularization on retinal structure and function is unclear. In vivo studies of retinal vascularization, thickness, and function were performed in mice with oxygen-induced retinopathy (OIR mice). METHODS: Eighteen mice were exposed to hyperoxia at postnatal day (P) 7, whereas 18 mice were raised in room air (RA). At P20 and 40, electroretinogram was performed for a-wave and b-wave amplitudes and peak times, followed by simultaneous fluorescein angiography for retinal avascular area, arterial tortuosity, and vein dilation assessments, and spectral domain optical coherence tomography for retinal thickness...
September 12, 2018: Eye
Efdal Yoeruek, Karl U Bartz-Schmidt
PURPOSE: To present a new surgical technique for treating corneal opacity and aniridia with aphakia and the results in a small consecutive case series. METHODS: A three-piece acrylic intraocular lens (IOL) was attached to a customized silicone iris prosthesis and fixed with three 10-0 polypropylene sutures in a knotless technique using Z-sutures after trephination of the recipient cornea. The medical records of all consecutive patients who had received a keratoplasty and an implantation of an artificial iris and IOL were reviewed...
September 12, 2018: Eye
Danilo A Jesus, João Barbosa Breda, Karel Van Keer, Amândio Rocha Sousa, Luis Abegão Pinto, Ingeborg Stalmans
PURPOSE: To develop a new methodology to detect glaucoma damage based on circumpapillary microvascular density (cpmVD) as measured by optical coherence tomography angiography (angioOCT). METHODS: AngioOCT scans from a random eye of 40 healthy subjects (aged 63 ± 14 years) and 82 glaucoma patients (aged 66 ± 9 years with an average visual field loss of -7.8 ± 6.5 dB) were used to develop a new angioOCT evaluation methodology. Optic disc-centred 3 × 3 mm images were collected (Angioplex® , Zeiss Cirrus 5000 HD-OCT)...
September 11, 2018: Eye
Shafi Balal, Phillip Smith, Tara Bader, Hongying Lilian Tang, Paul Sullivan, Ann Sofia Skou Thomsen, Tom Carlson, George M Saleh
PURPOSE: Objective feedback is important for the continuous development of surgical skills. Motion tracking, which has previously been validated across an entire cataract procedure, can be a useful adjunct. We aimed to measure quantitative differences between junior and senior surgeons' performance in three distinct segments. We further explored whether automated analysis of trainee surgical videos through PhacoTracking could be aligned with metrics from the EyeSi virtual reality simulator, allowing focused improvement of these areas in a controlled environment...
September 11, 2018: Eye
Neha Midha, Harsha L Rao, André Mermoud, Kaweh Mansouri
PURPOSE: To identify factors associated with probability of needling after XEN implant. METHODS: Analysis of data from prospective case series of patients with standalone XEN implant or combined XEN + cataract. Primary outcome was to determine whether postoperative day 1 and week 1 intraocular pressure (IOP), type of glaucoma, and glaucoma severity affected probability and number of needling interventions required. RESULTS: A total of 149 eyes of 113 patients were included in the analysis...
September 11, 2018: Eye
Saeed Karimi, Seyed Aliasghar Mosavi, Khosrow Jadidi, Homayoun Nikkhah, Bahareh Kheiri
PURPOSE: To evaluate the relationship between injection site and pain severity following intravitreal injection of bevacizumab (IVB). DESIGN: Prospective, randomized, four-armed, clinical trial. METHODS: The present study was a prospective, randomized, four-armed clinical trial, which included 1004 eyes from 1004 patients. Patients receiving IVB were randomly assigned into four groups: superotemporal (ST); superonasal (SN); inferotemporal (IT); and inferonasal (IN) injections...
September 10, 2018: Eye
John C Bladen, Ilan Feldman, Maribel Favor, Marizol Dizon, Andre Litwin, Raman Malhotra
PURPOSE: The purpose of this study was to assess the long-term outcome of onabotulinum used to treat facial dystonia and compare a flexible and fixed treatment regimen. METHODS: This was a retrospective comparative study looking at benign essential blepharospasm (BEB), hemifacial spasm (HFS) and aberrant facial nerve regeneration synkinesis (AFR) treatment with onabotulinum toxin A (Botox®) over a minimum of 10 years. Fifty-one patients were recruited into the study, with each dystonia subgroup having 17 patients...
September 10, 2018: Eye
Abby Willcox, Lucy Culliford, Lucy Ellis, Chris A Rogers, Angela Cree, Usha Chakravarthy, Sarah Ennis, Francine Behar-Cohen, Barnaby C Reeves, Sobha Sivaprasad, Andrew Lotery
AIMS: Chronic central serous chorioretinopathy (CSCR) is poorly understood. Fluid accumulates in the subretinal space and retinal pigment epitheliopathy and neurosensory atrophy may develop. Permanent vision loss occurs in approximately one third of cases. There are no effective treatments for CSCR. Recent studies have shown the mineralocorticoid receptor antagonist, eplerenone, to be effective in resolving subretinal fluid and improving visual acuity. This trial aims to compare the safety and efficacy of eplerenone in patients with CSCR in a double-masked randomised placebo-controlled trial...
September 7, 2018: Eye
K L Chan, J Deutsch, G Morphis, S Scotcher, A Smith, B While, S Madge
No abstract text is available yet for this article.
September 7, 2018: Eye
Doğaç Demir, Şefik Görkey
No abstract text is available yet for this article.
September 7, 2018: Eye
Giuseppe Giannaccare, Piera Versura, Francesca Bonifazi, Mariarosaria Sessa, Emilio C Campos
PURPOSE: To compare the proportion and the agreement rate in the diagnosis of chronic ocular graft-versus-host disease (GVHD) among three criteria applied with and without ophthalmological examination before hematopoietic stem cell transplantation (HSCT). METHODS: National Institutes of Health (NIH), International Consensus Criteria on ocular GVHD (ICCGVHD) and TFOS Dry Eye Workshop (DEWS) II criteria were used for the diagnosis of ocular GVHD according to two protocols: ophthalmological examination after HSCT (Protocol A), or before and after HSCT (Protocol B)...
September 7, 2018: Eye
M Piovella, S Colonval, A Kapp, J Reiter, F Van Cauwenberge, J Alfonso
PURPOSE: To evaluate clinical outcomes with a premium diffractive-refractive trifocal toric intraocular lens (IOL) over a 12-month period. METHODS: Multicentre prospective clinical trial including 227 eyes of 114 patients undergoing cataract surgery with bilateral implantation of the AT LISA tri toric 939MP IOL (Carl Zeiss Meditec, Jena, Germany). One patient was implanted unilaterally. Outcome measures were: visual acuity, manifest refraction, reading performance, contrast sensitivity, defocus curve, patient satisfaction and subjective quality of vision...
September 6, 2018: Eye
Ruoan Han, Chenxi Zhang, Xinyu Zhao, Youxin Chen
OBJECTIVE: To evaluate the efficacy of intravitreal injection (IVI) of expansile gas to treat primary full-thickness macular hole (FTMH). METHODS: Prospective interventional case series. Twenty-six eyes of 26 patients in Peking Union Medical College Hospital with primary FTMH underwent IVI of perfluoropropane (C3 F8 ) 0.2 ml, followed by 7-14 days' face-down positioning. The macular hole closure rate, post-operative visual acuity, and the incidence of surgical complications were observed...
September 5, 2018: Eye
Aniruddha Agarwal, Ankit Deokar, Ravi Sharma, Nirbhai Singh, Kanika Aggarwal, Suryaprakash Sharma, Ramandeep Singh, Aman Sharma, Kusum Sharma, Rupesh Agrawal, Reema Bansal, Vishali Gupta
PURPOSE: To analyze the serum cytokines profile in patients with tubercular multifocal serpiginoid choroiditis (TB MSC) receiving anti-tubercular therapy (ATT) and oral corticosteroids. METHODS: In this prospective longitudinal study, patients with active TB MSC were included. Serum levels of interferon (IFN)-γ, interleukin (IL)-10, and tumor necrosis factor (TNF)-α were analyzed using bead-based immunoassay. The levels of transforming growth factor (TGF)-β were measured using cytokine bead array...
September 5, 2018: Eye
Simon Wass, Grethe Albrektsen, Maria Tjåland Ødegård, Mari Sand, Dordi Austeng
PURPOSE: Examine the antiseptic effect of long-term low-concentration (0.3%) povidone-iodine (PI) before cataract surgery. SETTING: St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway. DESIGN: Single-armed prospective clinical study. METHODS: Repeated measure of preoperative conjunctival samples from 51 participants were obtained the day before surgery (T1), the day of surgery after treatment with ophthalmic NSAID (T2), and after additional treatment with low-concentration PI (T3) given by placing a pledget soaked in a mix of eye-drops in fornix inferior for 20 min...
August 31, 2018: Eye
Craig Wilde, Andrew R Ross, Senthil Maharajan
No abstract text is available yet for this article.
August 31, 2018: Eye
Deng-Juan Qian, Hua Zhong, Jun Li, Hu Liu, Chen-Wei Pan
PURPOSE: The aims of the study were to assess the magnitude and predictors of the unmet need for spectacles utilization and to quantify its impact on health-related quality of life (HRQOL) among rural Chinese adolescents. METHODS: This school-based survey of 2346 grade-7 students (mean age: 13.8 years) was conducted in Southwestern China in 2016. Spectacles need was defined as uncorrected visual acuity (VA) of 20/40 or worse but correctable to 20/40 or better in the better-seeing eye, together with the presence of myopia of less than -0...
August 29, 2018: Eye
S Lin, D Byles, M Smith
OBJECTIVES: To describe the 3-year outcomes of mitomycin C (MMC)-augmented bleb needling procedures following late trabeculectomy failure. METHODS: A retrospective, observational chart review of 44 eyes that underwent MMC-augmented bleb needling following late trabeculectomy failure. The primary outcome measure was IOP at 3 years post-operatively. Secondary outcome measures were the number of topical glaucoma medications and success rate at 3 years. Success was defined on the basis of IOP (≤21 mmHg and ≥5 mmHg with a reduction of ≥ 20% from pre-operative baseline), need for ocular hypotensive medications, and need for further laser or surgical intervention...
August 29, 2018: Eye
Xia Li, Yiqin Dai, Weiwei Xu, Jianjiang Xu
PURPOSE: To investigate the essential role of ultraviolet (UV) radiation in the decrease of corneal endothelial cell density (ECD) caused by pterygium. METHODS: In this retrospective controlled study, 76 consecutive patients with unilateral primary pterygium were enrolled from January 2016 to August 2016. The Central corneal ECD was measured in both eyes. Divide the subjects into two subgroups according to the UV exposure time, and the difference of corneal ECD between both eyes was analyzed using independent samples t-test...
August 29, 2018: Eye
Kyoko Ohno-Matsui, Makoto Suzaki, Rie Teshima, Nina Okami
OBJECTIVES: The aim of this study was to obtain real-world clinical data on the safety and efficacy of ranibizumab treatment for myopic choroidal neovascularization (CNV) due to pathologic myopia. METHODS: This was a prospective, observational, post-marketing surveillance study in ranibizumab-naive Japanese patients with myopic CNV. Patients who initiated ranibizumab treatment were registered and prospectively observed over 12 months. Safety endpoints were the incidence of ocular and non-ocular adverse drug reactions (ADRs) and serious adverse events (SAEs)...
August 29, 2018: Eye
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