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Gillian Gw Adams, Catey Bunce, Wen Xing, Lucilla Butler, Vernon Long, Aravind Reddy, Annegret H Dahlmann-Noor
AIMS: To evaluate retreatment rates, visual and anatomical outcomes at 1-year postnatal age in infants treated for retinopathy of prematurity (ROP) METHODS: Longitudinal national surveillance study of infants treated for ROP in the United Kingdom between December 2013 and December 2014, supported by the British Ophthalmic Surveillance Unit. Here we report retreatment rates, anatomical, visual and refractive outcomes at 1-year follow-up. RESULTS: One-year follow-up forms were completed for 168 children of the original cohort of 327 (51...
July 16, 2018: Eye
Kathleen R Chirco, Miles J Flamme-Wiese, Jill S Wiley, Lawrence A Potempa, Edwin M Stone, Budd A Tucker, Robert F Mullins
BACKGROUND: There is a considerable body of evidence demonstrating a link between the membrane attack complex (MAC) and age-related macular degeneration (AMD), and between C-reactive protein (CRP) and AMD. Both the MAC and the monomeric form of CRP (mCRP) accumulate within the choriocapillaris in AMD. However, the precise contribution of these species to AMD pathophysiology has not been fully elucidated. METHODS: We sought to directly assess CRP and MAC levels between human serum and ocular tissues from the same CFH Y402H genotyped donors using ELISA of serum and RPE/choroid proteins...
July 16, 2018: Eye
Heidi Laviers, Ji-Peng Olivia Li, Anna Grabowska, Stephen J Charles, David Charteris, Richard J Haynes, D Alistair H Laidlaw, David H Steel, David Yorston, Tom H Williamson, Hadi Zambarakji
PURPOSE: To study UK practice patterns for the management of retinal detachment secondary to macular hole (MHRD) and macular retinoschisis (MRS) in pathological myopia (PM). To review the anatomical and visual outcomes of the surgically managed cases. METHODS: A prospective observational case series for the management of MHRD was undertaken in association with the British Ophthalmological Surveillance Unit (BOSU). The results were combined with retrospective data, collected by the COllaboration of British RetinAl Surgeons (COBRA), on the management of both MHRD and MRS in PM in the UK...
July 16, 2018: Eye
Eleftherios I Agorogiannis, Ian A Pearce, Sohraab Yadav, David G Parry, Nicholas A V Beare
PURPOSE: To describe treatment outcomes in a cohort of Caucasian patients with polypoidal choroidal vasculopathy (PCV). METHODS: Clinical charts from 48 eyes of 45 Caucasian patients with PCV were retrospectively reviewed. All cases were diagnosed with indocyanine green angiography. Best corrected visual acuity (BCVA) and optical coherence tomography (OCT) imaging were analyzed at baseline and final follow-up. RESULTS: Eyes were treated with a combination of verteporfin photodynamic therapy (PDT) and anti-vascular endothelial growth factor (VEGF) (n = 24), or PDT monotherapy (n = 9), or anti-VEGF monotherapy (n = 8), or no treatment (n = 7)...
July 12, 2018: Eye
Chui Ming Gemmy Cheung, Won Ki Lee, Hideki Koizumi, Kunal Dansingani, Timothy Y Y Lai, K Bailey Freund
Pachychoroid is a relatively novel concept describing a phenotype characterized by attenuation of the choriocapillaris overlying dilated choroidal veins, and associated with progressive retinal pigment epithelium dysfunction and neovascularization. The emphasis in defining pachychoroid-related disorders has shifted away from simply an abnormally thick choroid (pachychoroid) toward a detailed morphological definition of a pathologic state (pachychoroid disease) with functional implications, which will be discussed in this review...
July 11, 2018: Eye
P Tumahai, C Moureaux, M Meillat, G Debellemanière, M Flores, B Delbosc, M Saleh
PURPOSE: To determine the effects of age on perifoveal cone density in healthy subjects using adaptive optics. METHODS: Healthy subjects of various ages were imaged using an adaptive optics retinal camera (RTX-1® Imagine Eyes, Orsay, France). All patients underwent a comprehensive ophthalmologic examination and retinal imaging using spectral-domain optical coherence tomography (Spectralis® , Heidelberg Engineering, Heidelberg, Germany). Cone density together with cone spacing and cone mosaic packing were measured in the nasal and temporal area 450 µm from the fovea...
July 11, 2018: Eye
Kwesi Nyan Amissah-Arthur, Evelyn Mensah
Sickle cell retinopathy is a potentially blinding condition that affects young people in the working age group. This review looks at the past, present and future management of sickle cell retinopathy within an African context. After Sickle cell disease was first reported in 1910, some reports from Africa were pivotal in describing the retinal changes associated with the disease. It soon became obvious that there was a varied clinical picture and clinical course. Several landmark studies were carried out in Jamaica to help elucidate the complexities of the disease and outline appropriate clinical management...
July 10, 2018: Eye
Dionysios Pagoulatos, Zoi Kapsala, Olga E Makri, Constantinos D Georgakopoulos
No abstract text is available yet for this article.
July 9, 2018: Eye
Daren Hanumunthadu, Elon H C Van Dijk, Sankeert Gangakhedkar, Abhilash Goud, Chui Ming Gemmy Cheung, Daniel Cherfan, Chintan Sarvaiya, Alay Banker, Catherine Meyerle, Camiel J Boon, Rishi Singh, Lihteh Wu, Jay Chhablani
BACKGROUND: Comparison of presentation and outcomes of central serous chorioretinopathy (CSC) between male and female subjects in different ethnic populations. METHODS: Retrospective comparison between male and female subjects with CSC was completed. Demographic details, clinical presentations, imaging features and treatment outcomes were compared at baseline and at last follow-up. RESULTS: This study included 155 male and 155 female subjects with a mean (CSD) age of 43...
July 9, 2018: Eye
Srishti Raj, Basavraj Tigari, T T Faisal, Natasha Gautam, Sushmita Kaushik, Parul Ichhpujani, Surinder S Pandav, Jagat Ram
BACKGROUND: To study the role of selective laser trabeculoplasty (SLT) in intraocular pressure (IOP) reduction in post-laser iridotomy primary angle-closure disease patients with inadequately controlled IOP. METHODS: In this prospective cross-sectional study, 34 patients with primary angle-closure disease with post-laser iridotomy open angles up to at least 180° were recruited. Following SLT, patients were examined at 1 day, 1 week, 1 and 3 months, 6 months and 1 year post SLT...
July 9, 2018: Eye
Perach Osaadon, Erez Tsumi, Russell Pokroy, Tsvi Sheleg, Kobi Peleg
PURPOSE: To determine the characteristics of ocular injuries treated by Israel Defense Forces (IDF) field hospital following three natural disasters: the 2010 earthquake in Haiti, the 2013 typhoon in the Philippines, and the 2015 earthquake and avalanche in Nepal. The purpose was to provide data, which would assist allocation of ocular resources for future disasters. DESIGN: Retrospective database study. METHODS: Ocular clinical data collected from the IDF database...
July 9, 2018: Eye
Mariam El-Abiary, Brian Jones, Graeme Williams, David Lockington
INTRODUCTION: Although the worldwide prevalence of disseminated candidaemia is rising, reported intraocular candidiasis rates are variable, even as low as 1%. The Infectious Diseases Society of America recommends fundoscopy screening for all fungal blood culture positive patients. We wished to evaluate the impact of this recommendation on our department. METHODS: A retrospective observational study was performed in NHS Greater Glasgow and Clyde (population = 1.15 million) for all patients with candida positive blood culture results over a 2-year period...
July 6, 2018: Eye
Radhika Patel, David Lockington
No abstract text is available yet for this article.
July 4, 2018: Eye
Diego Torres Dias, Izabela Almeida, Adriana Miyuki Sassaki, Verena Ribeiro Juncal, Michele Ushida, Flavio Siqueira Lopes, Paula Alhadeff, Robert Ritch, Tiago Santos Prata
PURPOSE: Glaucomatous eyes with disc hemorrhage (DH) have a greater risk of paracentral visual field (VF) loss. However, not every DH eye presents with parafoveal scotoma (PFS), and contributing factors are still to be determined. In the present study, we investigated clinical and ocular factors associated with the presence of PFS in glaucomatous eyes with DH. METHODS: A case-control study was carried out. One hundred thirty glaucomatous patients with DH were enrolled...
July 4, 2018: Eye
Hans Callø Fledelius, Patricia Louise Danielsen, Susanne Ullman
BACKGROUND: To evaluate ophthalmic involvement in a long-term series of patients with en coup de sabre (ECS) close to the eye based on the hypothesis that this is not commonly affected, or simply under-reported. METHODS: An observational study of ophthalmological findings in patients from Copenhagen University Dermatology Clinics. A standard eye examination further included exophthalmometry, axial length and keratometry (IOLMaster), and horizontal eye muscle thickness (B-scan ultrasonography)...
July 4, 2018: Eye
Vanita Berry, Alexander C W Ionides, Nikolas Pontikos, Ismail Moghul, Anthony T Moore, Michael E Cheetham, Michel Michaelides
PURPOSE: Congenital cataract, opacification of the ocular lens, is clinically and genetically a heterogeneous childhood disease. In this study we aimed to identify the underlying genetic cause of isolated autosomal-dominant lamellar cataract in a multi-generation English family. METHODS: Whole-genome sequencing (WGS) was undertaken in two affected subjects and one unaffected individual. Segregation analysis was performed and a known cataract-causing mutation was identified...
June 22, 2018: Eye
Siwen Zang, Ying Cui, Yang Cui, Wenlei Fei
PURPOSE: The purpose of this study is to explore the differences in ocular symptoms and signs between Sjögren's syndrome (SS) and non-SS aqueous-deficient dry eye (ADDE) patients. METHODS: Twenty-two eyes of 22 SS patients (Group 1) and 22 eyes of 22 non-SS ADDE patients (Group 2) were enrolled. The evaluated variables included the Standard Patient Evaluation of Eye Dryness (SPEED), the Ocular Surface Disease Index (OSDI), tear meniscus height, first and average non-invasive keratographic breakup time (fNIKBUT and avNIKBUT), Schirmer I test, lipid layer thickness (LLT), meibomian gland expressibility, Marx line, corneal staining, conjunctival congestion, incomplete blinking, and meibomian gland dropout using two novel, non-invasive instruments, the Keratograph and LipiView II...
June 22, 2018: Eye
Suman Pilli, Peck Lin Lip
No abstract text is available yet for this article.
June 22, 2018: Eye
Thi Kieu Hau Hoang, Young Kook Kim, Jin Wook Jeoung, Ki Ho Park
Since the online publication of the above article, the authors have noted errors with Table 2. The corrected Table 2 can be found below.
June 21, 2018: Eye
Samantha Bobba, Connor Devlin, Nick Di Girolamo, Denis Wakefield, Peter McCluskey, Elsie Chan, Mark Daniell, Stephanie Watson
AIMS: This study aimed to determine the incidence, clinical features and management of cicatrising conjunctivitis in Australia and New Zealand, also enabling comparison with data from the United Kingdom. METHODS: A prospective surveillance study was conducted over 17 months via the Australian and New Zealand Ophthalmic Surveillance Unit with a one-year follow-up period. Practicing ophthalmologists on the Surveillance Unit's database were asked to report recently diagnosed cases of cicatrising conjunctivitis on a monthly basis...
June 19, 2018: Eye
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