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https://www.readbyqxmd.com/read/30635644/smartphone-based-application-improves-the-detection-of-retinoblastoma
#1
Amit Khedekar, Bharanidharan Devarajan, Kim Ramasamy, Veerappan Muthukkaruppan, Usha Kim
PURPOSE: To improve and validate the smartphone-based leukocoria detection application so that non-ophthalmologists could make use of the smartphone for early detection of Retinoblastoma (RB) in young children without anesthesia and pharmacological dilatation of the pupil. METHODS: Two apps, MDEyeCare and CRADLE, developed for red reflex based leukocoria detection were used in iPhone 6s. MDEyeCare methodology was modified with respect to ambient lighting, the distance between camera and eye and different gazes for better performance...
January 11, 2019: Eye
https://www.readbyqxmd.com/read/30635643/non-physician-grader-reliability-in-measuring-morphological-features-of-the-optic-nerve-head-in-stereo-digital-images
#2
Victoria Addis, Enny Oyeniran, Ebenezer Daniel, Rebecca Salowe, Richard Zorger, Roy Lee, Maxwell Pistilli, Maureen Maguire, Qi Cui, Eydie Miller-Ellis, Joan M O'Brien, Prithvi S Sankar
OBJECTIVE: To introduce a new method of grading optic nerve stereo disc photographs and evaluate reproducibility of assessments by non-physician graders in a reading center. METHODS: Three non-physician graders, experienced in grading features of the retina but not the optic nerve head (ONH), were trained by glaucoma specialists to assess digital stereo color images of the ONH. These graders assessed a total of 2554 digital stereo disc images from glaucoma cases and controls participating in the Primary Open-Angle African American Glaucoma Genetics (POAAGG) study by outlining the optic cup and disc...
January 11, 2019: Eye
https://www.readbyqxmd.com/read/30622289/a-renaissance-of-teleophthalmology-through-artificial-intelligence
#3
EDITORIAL
Edward Korot, Edward Wood, Adam Weiner, Dawn A Sim, Michael Trese
No abstract text is available yet for this article.
January 8, 2019: Eye
https://www.readbyqxmd.com/read/30622288/cytomegalovirus-infection-is-not-a-major-cause-of-corneal-graft-failure-in-the-united-kingdom
#4
Claudia A da Costa Paula, Daniel M Gore, Khilan Shah, Geert Kuit, Romesh I Angunawela, James P Barnett, Stephen J Tuft
BACKGROUND: Cytomegalovirus (CMV) endotheliitis is a significant cause for acute corneal allograft rejection in East Asian populations, where there is a high CMV seroprevalence. To determine how frequently CMV is associated with corneal graft failure in the UK, we looked for the presence of CMV DNA in grafts that had failed and had been removed at repeat keratoplasty. We also looked for CMV DNA in corneal rims discarded after corneal transplantation. METHODS: In this retrospective study, we identified 54 cases of corneal graft failure following endothelial rejection and 38 control grafts that had failed without a history of endothelial rejection...
January 8, 2019: Eye
https://www.readbyqxmd.com/read/30617289/ocular-abnormalities-and-complications-in-anterior-megalophthalmos-a-case-series
#5
Devesh Kumawat, Tanveer Alam, Pranita Sahay, Rohan Chawla
OBJECTIVES: To describe the clinical and Scheimpflug imaging features in cases of anterior megalophthalmos (AM). METHODS: Retrospective record review was performed for patients with AM who presented between June 2017 and May 2018. Clinical history, slit lamp examination, Scheimpflug imaging indices (Pentacam-HR, Oculus, GmbH), dilated fundus examination and treatment records were reviewed. RESULTS: The study included eight eyes of four male patients (mean age 6...
January 7, 2019: Eye
https://www.readbyqxmd.com/read/30617288/royal-college-of-ophthalmologists-national-survey-of-st1-supervision
#6
Christopher King, Alex Tytko, Anne Fiona Spencer, Anna Mead
No abstract text is available yet for this article.
January 7, 2019: Eye
https://www.readbyqxmd.com/read/30617287/trainee-confidence-managing-ocular-trauma
#7
LETTER
Amy-Lee Shirodkar, Damien Cm Yeo, Mr Gary Shuttleworth
No abstract text is available yet for this article.
January 7, 2019: Eye
https://www.readbyqxmd.com/read/30610230/effectiveness-and-safety-of-accelerated-9-mw-cm-2-corneal-collagen-cross-linking-for-progressive-keratoconus-a-24-month-follow-up
#8
Darren Shu Jeng Ting, Romeela Rana-Rahman, Yunzi Chen, Dugald Bell, Jean-Pierre Danjoux, Stephen J Morgan, Saurabh Ghosh, Oliver Baylis
OBJECTIVES: To examine the effectiveness and safety of accelerated corneal collagen cross-linking (CXL) for keratoconus over a 24-month period and to explore potential prognostic factors for post-treatment visual outcome and progression. METHODS: A retrospective, non-comparative, interventional case series. All patients who underwent accelerated epithelium-off CXL, using 9 mW/cm2 ultraviolet-A irradiation for 10 min, for progressive keratoconus in Sunderland Eye Infirmary, UK, between May 2014 and July 2016 were included...
January 4, 2019: Eye
https://www.readbyqxmd.com/read/30610229/interruption-of-autoimmunity-for-thyroid-eye-disease-b-cell-and-t-cell-strategy
#9
Diego Strianese, Francesca Rossi
Recent new insights into the molecular basis of thyroid eye disease have led to the use of more specific therapies such as monoclonal antibodies This review explores the traditional immunosuppressant therapy for TED, highlighting the basis for emergent recent medications, possible treatment options and, eventually possible new general recommendation for management of TED. Data has been retrieved from the literature searching on Pubmed. Steroid therapy remains the first line therapy for moderate/severe and severe vision threatening TED The use of some traditional nonspecific immunosuppressant such as mycophenolate, cyclosporine and azathioprine seems useful in combination with steroid therapy to achieve stable results in the long term; methotrexate is useful as steroid-sparing medications and in steroid resistant or intolerant patients...
January 4, 2019: Eye
https://www.readbyqxmd.com/read/30610228/short-duration-multiple-session-subthreshold-micropulse-yellow-laser-577-nm-for-chronic-central-serous-chorioretinopathy-results-at-3-years
#10
Yang Jae Kim, Si Yeol Kim, Seungmin Ha, Daruchi Moon, San Seong, Oh Woong Kwon, Han Sang Park
OBJECTIVES: To review the 3-year follow-up results of subthreshold micropulse yellow laser (SMYL) delivered by a short-duration multiple-session method for treatment of chronic central serous chorioretinopathy (CSC). METHODS: A total of 27 eyes from 27 patients with chronic CSC available for 3 years of follow-up were enrolled in this retrospective and interventional study. Patients were treated with 577-nm SMYL photocoagulation at a 15% duty cycle over multiple sessions, with low power ranging from 200 to 400 mW that was increased in 100 mW increments according to resolution of subretinal fluid at monthly follow-up...
January 4, 2019: Eye
https://www.readbyqxmd.com/read/30602756/influence-of-peripheral-corneal-relaxing-incisions-during-cataract-surgery-for-corneal-astigmatism-up-to-2-5-dioptres-on-corneal-densitometry
#11
Ieva Zukaite, Kaveeta K Bedi, Shahnaz Ali, Mayank A Nanavaty
PURPOSE: To assess the effect of peripheral corneal relaxing incisions (PCRI) for astigmatism between 0.75 and 2.5 dioptres during cataract surgery on corneal densitometry (CD). METHODS: In this prospective, randomised study, 80 eyes (80 patients), received either tIOL or PCRI. Assessment at pre-operative and 1, 3, 6, 12 months post-operative visit included uncorrected (UCDVA) and best-corrected distance visual acuity (BCDVA), spherical equivalent (SEQ) (only post-operatively), mean anterior and posterior keratometric astigmatism (KA ) and CD with Schiempflug system...
January 2, 2019: Eye
https://www.readbyqxmd.com/read/30593587/a-prospective-study-of-the-incidence-associations-and-outcomes-of-ocular-surface-squamous-neoplasia-in-the-united-kingdom
#12
Christine A Kiire, Rosalind M K Stewart, Sathish Srinivasan, Heinrich Heimann, Stephen B Kaye, Baljean Dhillon
PURPOSE: To describe the incidence, associations and outcomes of ocular surface squamous neoplasia (OSSN) in the United Kingdom. METHODS: Prospective, observational study of every new case of OSSN reported via the British Ophthalmological Surveillance Unit reporting scheme over a 12-month period. Cases were followed up for 12 months. RESULTS: The reported incidence of OSSN was 0.53 cases/million/year (conjunctival intraepithelial neoplasia: 0...
December 28, 2018: Eye
https://www.readbyqxmd.com/read/30575804/teprotumumab-an-insulin-like-growth-factor-1-receptor-antagonist-antibody-in-the-treatment-of-active-thyroid-eye-disease-a-focus-on-proptosis
#13
REVIEW
Raymond S Douglas
Thyroid eye disease is a disabling autoimmune disease associated with orbital inflammation and tissue remodeling which can result in significant proptosis, leading to visual alterations and is potentially sight threatening. Current evidence indicates that autoantibodies to the insulin-like growth factor 1 receptor (IGF-1R), along with the thyroid-stimulating hormone receptor (TSHR), mediate the pathogenesis in susceptible individuals. Teprotumumab, a monoclonal IGF-1R antagonist, has demonstrated previously in a 24 week, randomized, controlled trial to produce significant changes in composite outcomes of proptosis and clinical activity score as compared with placebo...
December 21, 2018: Eye
https://www.readbyqxmd.com/read/30568256/vitrectomy-with-scleral-buckling-versus-with-inferior-retinectomy-in-treating-primary-rhegmatogenous-retinal-detachment-with-pvr-and-inferior-breaks
#14
LETTER
Khaled G Abu Eleinen, Ahmed A Mohalhal, Dalia A Ghalwash, Ahmed A Abdel-Kader, Ahmed A Ghalwash, Islam A Mohalhal, Abdussalam M Abdullatif
No abstract text is available yet for this article.
December 19, 2018: Eye
https://www.readbyqxmd.com/read/30568255/cambridge-ophthalmological-symposium-2018-introduction-and-reflections-on-the-day
#15
EDITORIAL
Marian Ludgate
I was privileged to be one of the co-chairs, along with Professor Tim Sullivan (Brisbane, Australia), for the Cambridge Ophthalmological Society (COS) annual international symposium, which, this year, was dedicated to thyroid eye disease (TED). Together with the organisers, Miss Rachna Murthy and Professor Keith Martin from COS, we compiled an impressive programme covering all aspects of the condition from events happening in a single orbital cell to improved surgical approaches.
December 19, 2018: Eye
https://www.readbyqxmd.com/read/30560917/ykl-40-is-a-local-marker-for-inflammation-in-patients-with-pseudoexfoliation-syndrome
#16
Tansu Gonen, Savas Guzel, Kadircan H Keskinbora
PURPOSE: To investigate the YKL-40, as a marker of inflammation, in aqueous humor and serum of cataract patients with and without pseudoexfoliation syndrome (PEX). METHODS: Aqueous humor and serum samples were obtained from 44 patients who underwent phacoemulsification surgery. All patients were divided into two groups: PEX (n = 24) and control (n = 20). YKL-40 levels were measured with enzyme-linked immunosorbent assay (ELISA). The differences between the groups were assessed by using Chi-square and independent sample t-tests...
December 18, 2018: Eye
https://www.readbyqxmd.com/read/30560916/prospective-analysis-of-the-predictors-of-glaucoma-following-surgery-for-congenital-and-infantile-cataract
#17
Shantha Balekudaru, Sumita Agarkar, Sujatha Guha, Rishikesh Charudatta Mayee, Natarajan Viswanathan, Amit Pandey, Maneesh Singh, Vijaya Lingam, Ronnie George
PURPOSE: A prospective longitudinal cohort study was performed to assess the incidence of and risk factors for the development of glaucoma following surgery for congenital/infantile cataract. METHODS: One hundred and one eyes of one hundred and one children, ≤12 years of age who had follow-up of ≥24 months were included. Group I included those who underwent surgery using an anterior approach, group II included those who underwent surgery using a posterior approach, and group III included those who underwent surgery using an anterior approach along with foldable intraocular lens implantation...
December 18, 2018: Eye
https://www.readbyqxmd.com/read/30560915/comment-on-vitrectomy-with-scleral-buckling-versus-with-inferior-retinectomy-in-treating-primary-rhegmatogenous-retinal-detachment-with-pvr-and-inferior-breaks
#18
LETTER
Upma Awasthi, Rohini Grover, Chetan Videkar, Abhishek Varshney
No abstract text is available yet for this article.
December 18, 2018: Eye
https://www.readbyqxmd.com/read/30560914/response-to-comment-on-eponymous-women-in-ophthalmology-syndromes-with-prominent-eye-manifestations-named-after-female-physicians
#19
LETTER
Sarah H Van Tassel, Kira L Segal, Jessica B Ciralsky, Grace Sun
No abstract text is available yet for this article.
December 18, 2018: Eye
https://www.readbyqxmd.com/read/30560913/kaempferol-attenuates-retinal-ganglion-cell-death-by-suppressing-nlrp1-nlrp3-inflammasomes-and-caspase-8-via-jnk-and-nf-%C3%AE%C2%BAb-pathways-in-acute-glaucoma
#20
Chaobin Lin, Fujin Wu, Tongmei Zheng, Xiuchun Wang, Yiwei Chen, Xiaomin Wu
AIMS OR PURPOSE: Glaucoma is the leading cause of vision loss and blindness in the world. Elucidating the pathogenesis of glaucoma and developing effective treatment should be the priority. Inflammation and oxidative stress play essential roles in glaucoma pathogeneisis. Kaempferol is a natural flavonol and has anti-inflammatory and anti-oxidative activities. In this study, we explored the potential effects of kaempferol on acute glaucoma. METHODS: We established the retinal ischemia-reperfusion (I/R) mice model and administrated kaempferol to I/R mice...
December 18, 2018: Eye
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