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Parasitology Research

Bartolo Avendaño-Borromeo, Ravi Kumar Narayanasamy, Guillermina García-Rivera, María Luisa Labra-Barrios, Anel E Lagunes-Guillén, Bibiana Munguía-Chávez, Carlos Alberto Castañón-Sánchez, Esther Orozco, Juan Pedro Luna-Arias
Transcription factor IID (TFIID) is a cornerstone in the transcription initiation in eukaryotes. It is composed of TBP and approximately 14 different subunits named TBP-associated factors (TAFs). TFIID has a key role in transcription of many genes involved in cell proliferation, cell growth, cell cycle, cell cycle checkpoint, and various other processes as well. Entamoeba histolytica, the protozoan parasite responsible for human amoebiasis, represents a major global health concern. Our research group has previously reported the genes coding the TATA box-binding protein (EhTBP) and TBP-related factor 1 (EhTRF1), which displayed different mRNA levels in trophozoites under different stress conditions...
December 15, 2018: Parasitology Research
Walter Basso, Lisa-Maria Grandt, Anne-Laure Magnenat, Bruno Gottstein, Miguel Campos
Strongyloides stercoralis is a worldwide-distributed intestinal nematode affecting mainly humans and dogs. Canine strongyloidosis is generally characterised by diarrhoea, malabsorption and bronchopneumonia, and may be fatal in cases of impaired immunity. In recent years, molecular and epidemiological studies suggested that host-adapted populations of S. stercoralis with different zoonotic potential may exist. Clinical and subclinical cases of S. stercoralis infection have been increasingly diagnosed in imported (France, Belgium, Bulgaria) and locally born dogs in Switzerland, showing that this parasite is currently circulating in Europe...
December 14, 2018: Parasitology Research
Rahul Pasupureddy, Atul, Sriram Seshadri, Veena Pande, Rajnikant Dixit, Kailash C Pandey
Author Atul Yadav would like to present his name as Atul only to be the same with his previous publications. The original article has been corrected.
December 14, 2018: Parasitology Research
Ana L Sereno-Uribe, Leopoldo Andrade-Gómez, Gerardo Pérez Ponce de León, Martín García-Varela
Members of the genus Tylodelphys Diesing, 1850 are endoparasites of fish-eating birds, particularly ciconiids, anhingids, and podicipedids across the globe. Metacercariae of Tylodelphys spp. were collected from the cranial and body cavities of freshwater fishes in central and northern Mexico; adults were recovered from the intestine of two species of freshwater diving birds of the family Podicipedidae, commonly known as grebes, in two locations of central Mexico. Specimens were sequenced for two molecular markers, the internal transcribed spacers (ITS1 and ITS2) plus 5...
December 14, 2018: Parasitology Research
S El-Sherry, M E Ogedengbe, M A Hafeez, M Sayf-Al-Din, N Gad, J R Barta
Differentiating the Eimeria species causing cecal coccidiosis in turkeys is challenging. To obtain benchmark biological data for Eimeria gallopavonis Hawkins 1952 and Eimeria meleagridis Tyzzer 1929 and to support the stability of the species concept for each, genetically typed, single oocyst-derived lines of E. gallopavonis Weybridge strain and E. meleagridis USAR97-01 were used to redescribe the biological, pathological, and morphological features of these parasites. Oocysts of E. meleagridis and E. gallopavonis overlap in dimensions, but oocysts of the former have a single polar granule compared with multiple in the latter...
December 13, 2018: Parasitology Research
Alsácia Atanásio-Nhacumbe, Sabrina Mota Lambert, Bárbara Maria Paraná da Silva Souza, Maria Consuêlo Carybé Ayres
Benzimidazole (BZ) resistance of Haemonchus contortus has been associated with single nucleotide polymorphisms (SNPs) in codons 200 (F200Y) and 167 (F167Y) and, to a lesser extent, in codon E198A, of the β-tubulin isotype 1 gene. The present study was undertaken to survey the status of BZ resistance in naturally infected goats in smallholder farms in southern Mozambique by real-time PCR (qPCR) using TaqMan® assays. H. contortus-infective larvae (L3; n = 432) from 12 populations were individually genotyped for F200Y and F167Y SNPs to detect BZ resistance...
December 13, 2018: Parasitology Research
Katarzyna Rydzanicz, Elzbieta Golab, Wioletta Rozej-Bielicka, Aleksander Masny
In recent years, numerous studies screening mosquitoes for filarioid helminths (xenomonitoring) have been performed in Europe. The entomological monitoring of filarial nematode infections in mosquitoes by molecular xenomonitoring might serve as the measure of the rate at which humans and animals expose mosquitoes to microfilariae and the rate at which animals and humans are exposed to the bites of the infected mosquitoes. We hypothesized that combining the data obtained from molecular xenomonitoring and phenological studies of mosquitoes in the urban environment would provide insights into the transmission risk of filarial diseases...
December 8, 2018: Parasitology Research
Arif Ciloglu, Vincenzo A Ellis, Rasa Bernotienė, Gediminas Valkiūnas, Staffan Bensch
Accurate detection and identification are essential components for epidemiological, ecological, and evolutionary surveys of avian haemosporidian parasites. Microscopy has been used for more than 100 years to detect and identify these parasites; however, this technique requires considerable training and high-level expertise. Several PCR methods with highly sensitive and specific detection capabilities have now been developed in addition to microscopic examination. However, recent studies have shown that these molecular protocols are insufficient at detecting mixed infections of different haemosporidian parasite species and genetic lineages...
December 7, 2018: Parasitology Research
Márcia Rodrigues Trein, Lígia Rodrigues E Oliveira, Graziela Vargas Rigo, Mayara Aparecida Rocha Garcia, Brenda Petro-Silveira, Danielle da Silva Trentin, Alexandre José Macedo, Luis Octávio Regasini, Tiana Tasca
Trichomoniasis is the most common non-viral sexually transmitted disease worldwide and can lead to serious consequences in reproductive health, cancer, and HIV acquisition. The current approved treatment present adverse effects and drug resistance data on this neglected parasitic infection is underestimated. Chalcones are a family of molecules that present biological applications, such as activity against many pathogenic organisms including protozoan pathogens. Chalcone (1) and three amino-analogues (2-4) were synthesized by Claisen-Schmidt condensation reaction and had their activity evaluated against the parasitic protozoan Trichomonas vaginalis...
December 7, 2018: Parasitology Research
Mariana de Souza Terron-Monich, Izabel Galhardo Demarchi, Pollyanna Rina Ferreira da Silva, Áquila Carolina Fernandes Herculano Ramos-Milaré, Zilda Cristiani Gazim, Thaís Gomes Verzignassi Silveira, Maria Valdrinez Campana Lonardoni
The treatment of cutaneous leishmaniasis in associated with several adverse effects and therapeutic failure, resulting in patients' abandonment of treatment. Research on new drugs with leishmanicidal potential from medicinal plants is essential. The anti-Leishmania activity of Tetradenia riparia essential oil (TrEO) and its derivatives, such as the diterpene 6,7-dehydroroyleanone (TrROY), and the immunomodulatory effects of TrEO have been reported. However, few studies have investigated the effects of TrROY...
December 5, 2018: Parasitology Research
Carlos J Ramírez-Flores, Rosalba Cruz-Mirón, Rossana Arroyo, Mónica E Mondragón-Castelán, Tais Nopal-Guerrero, Sirenia González-Pozos, Emmanuel Ríos-Castro, Ricardo Mondragón-Flores
Toxoplasma gondii can infect all nucleated cells from warm-blooded organisms. After infection, Toxoplasma spreads throughout the body and migrates across biological barriers, such as the intestinal and blood-brain barriers, as well as the placenta in pregnant women. The mechanisms for parasite dissemination are still unknown; however, proteases could play a role as a virulence factor. The aim of this study was to detect and to characterize proteases in whole-cell extracts and in excretion/secretion products from tachyzoites of the RH strain isolated from infected mice...
December 1, 2018: Parasitology Research
David Iván Hernández-Mena, Carlos Daniel Pinacho-Pinacho, Martín García-Varela, Berenit Mendoza-Garfias, Gerardo Pérez-Ponce de León
Integrative taxonomy uses several sources of information to establish more robust species delimitation criteria. In this study, we followed that approach to describe two new species of allocreadiid trematodes from freshwater fish distributed in locations across Middle America. The new species were first recognized by using sequences of the domains D1-D3 of the ribosomal 28S rRNA gene and then, morphological data (light and scanning electron microscopy (SEM)), host association, and geographical distribution were considered as additional sources of information to complement the species delimitation and description...
December 1, 2018: Parasitology Research
Paulo Renato Rivas Totino, Hugo Amorim Dos Santos de Souza, Edmar Henrique Costa Correa, Cláudio Tadeu Daniel-Ribeiro, Maria de Fátima Ferreira-da-Cruz
It is known that premature elimination of non-parasitized RBCs (nRBCs) plays an important role in the pathogenesis of malarial anemia, in which suicidal death process (eryptosis) of nRBCs has been suggested to be involved. To check this possibility, we investigate eryptosis during infection of P. berghei ANKA in Wistar rats, a malaria experimental model that, similar to human malaria, the infection courses with low parasitemia and acute anemia. As expected, P. berghei ANKA infection was marked by low parasite burdens that reached a mean peak of 3% between days six and nine post-infection and solved spontaneously...
December 1, 2018: Parasitology Research
Galit Sharon, Michal Ucko, Ben Tamir, Arik Diamant
Gray mullet (Mugilidae) occur in all seas and are farmed widely around the world, and thus, the risk of their parasites spreading through transport of aquaculture seed is a serious concern. Among others, gray mullets typically host a diversity of myxosporeans, a group in which spore morphometrics of genera has been consistently shown to be inadequate for determination of species. In this study, we investigated Myxobolus Bütschli 1882 (Myxosporea) species found in two fingerling stocks of Mugil cephalus caught in the wild off the coasts of the eastern (Israel) and western (Spain) Mediterranean...
November 29, 2018: Parasitology Research
Liuting Chen, Yang Yu, Ertao Liu, Lian Duan, Dandan Zhu, Jinling Chen, Jia Dai, Yinong Duan
Hepatic fibrosis is characterized by the activation of the main collagen-producing cells of the liver, hepatic stellate cells, and is associated with inflammation. Although the involvement of numerous inflammatory cytokines has been reported, IL-34 in particular has recently been identified as a profibrotic factor in the development of hepatic fibrosis. Previous studies have found that schistosome eggs can lead to transcriptional downregulation of fibrosis-associated genes, and based on this evidence, we attempted to investigate whether or not IL-34 is regulated by soluble egg antigen (SEA)...
November 29, 2018: Parasitology Research
Lenka Lecová, Pavla Tůmová, Eva Nohýnková
The level of genetic variability of Giardia intestinalis clinical isolates is an intensively studied and discussed issue within the scientific community. Our collection of G. intestinalis human isolates includes six in vitro-cultured isolates from assemblage B, with extensive genetic variability. Such variability prevents the precise genotype characterisation by the multi-locus genotyping (MLG) method commonly used for assemblage A. It was speculated that the intra-assemblage variations represent a reciprocal genetic exchange or true mixed infection...
November 28, 2018: Parasitology Research
A Trujillo-González, J A Becker, D B Vaughan, K S Hutson
The phylogenetic tree (Figure 7) in the published document has incorrect Bayesian analysis posterior probabilities. This error prevents accurate analysis by future research in parasitology. The figure is therefore replaced by the corrected figure below.
November 27, 2018: Parasitology Research
Jenny G Maloney, Jason E Lombard, Natalie J Urie, Chelsey B Shivley, Monica Santin
Blastocystis is an emerging zoonotic pathogen with global distribution. However, limited data exist on the prevalence and genetic diversity of Blastocystis in the USA and in food animals. We conducted the first large-scale molecular investigation of Blastocystis in the USA by testing 2539 fecal samples from dairy heifer calves from 13 states. Blastocystis was detected in 73 (2.9%) fecal samples and in 10 of the 13 tested states. Molecular characterization showed a wide diversity of subtypes. Eleven subtypes were identified, seven previously reported (ST-3, ST-4, ST-5, ST-10, ST-14, ST-17, and ST-21) and four potentially novel subtypes (named ST-23 to ST-26)...
November 27, 2018: Parasitology Research
Rahul Pasupureddy, Atul Yadav, Sriram Seshadri, Veena Pande, Rajnikant Dixit, Kailash C Pandey
Despite several setbacks in the fight against malaria such as insecticide and drug resistance as well as low efficacy of available vaccines, considerable success in reducing malaria burden has been achieved in the past decade. Artemisinins (ARTs and their combination therapies, ACTs), the current frontline drugs against uncomplicated malaria, rapidly kill plasmodial parasites and are non-toxic at short exposures. Though the exact mode of action remains unclear, the endoperoxide bridge, indispensable for ART activity, is thought to react with heme released from hemoglobin hydrolysis and generate free radicals that alkylate multiple protein targets, thereby disrupting proteostasis pathways...
November 26, 2018: Parasitology Research
Jiaying Guo, Xiaoyan Miao, Pei He, Muxiao Li, Sen Wang, Jie Cui, Cuiqin Huang, Lan He, Junlong Zhao
Babesia gibsoni (B. gibsoni), an intracellular apicomplexan protozoan, poses great threat to canine health. Currently, little information is available about the B. gibsoni (WH58) endemic to Wuhan, China. Here, the mitochondrial (mt) genome of B. gibsoni (WH58) was amplified by five pairs of primers and sequenced and annotated by alignment with the reported mt genome sequences of Babesia canis (B. canis, KC207822), Babesia orientalis (KF218819), Babesia bovis (AB499088), and Theileria equi (AB499091). The evolutionary relationships were analyzed with the amino acid sequences of cytochrome c oxidase I (cox1) and cytochrome b (cob) genes in apicomplexan parasite species...
November 24, 2018: Parasitology Research
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