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Parasitology Research

Oliver Stevanović, Igor Trbojević, Sonja Nikolić, Violeta Santrač
This paper represents the first description of advanced aelurostrongylosis in the Eurasian badger (Меles meles, L. 1758) from Bosnia and Herzegovina, which is an autochthonous species of the country. An adult female badger was found dead on a road; the cause of death was trauma but the emphasis in the paper is on severe verminous pneumonia caused by metastrongylids from genus Aelurostrongylus spp. This parasitological and histopathological finding confirms the presence of Aelurostrongylus in mustelids in Bosnia and Herzegovina and the Balkans...
June 23, 2018: Parasitology Research
Á Dán, Z Rónai, Z Széll, T Sréter
A study was conducted to investigate genetic diversity of Echinococcus isolates collected in Hungarian slaughterhouses between 2015 and 2018. Organs of 219 animals with suspected hydatidosis were collected during routine meat inspection and sent to our laboratory. Echinococcus infection was confirmed in 65 animals. These results indicate that prevalence data based on reporting of slaughterhouses are not reliable without the appropriate training of the people responsible for meat inspection. The genetic diversity was evaluated by the DNA sequence analysis of the cytochrome c oxydase subunit 1 (cox1) mitochondrial gene...
June 22, 2018: Parasitology Research
Juliana de A Portes, Nathália F B Azeredo, Pedro G T Siqueira, Tatiana Guinancio de Souza, Christiane Fernandes, Adolfo Horn, Dalber R S Candela, Wanderley de Souza, Renato A DaMatta, Sérgio H Seabra
We have previously shown that metallocomplexes can control the growth of Toxoplasma gondii, the agent that causes toxoplasmosis. In order to develop new metallodrugs to treat this disease, we investigated the influence of the coordination of sulfadiazine (SDZ), a drug used to treat toxoplasmosis, on the biological activity of the iron(III) complex [Fe(HBPClNOL)Cl2 ]·H2 O, 1, (H2 BPClNOL=N-(2-hydroxybenzyl)-N-(2-pyridylmethyl)(3-chloro)(2-hydroxy)-propylamine). The new complex [(Cl)(SDZ)Fe(III)(μ-BPClNOL)2 Fe(III)(SDZ)(Cl)]·2H2 O, 2, which was obtained by the reaction between complex 1 and SDZ, was characterized using a range of physico-chemical techniques...
June 22, 2018: Parasitology Research
Manuel Ritter, Vanessa Krupp, Katharina Wiszniewsky, Anna Wiszniewsky, Gnatoulma Katawa, Ruth S E Tamadaho, Achim Hoerauf, Laura E Layland
Lymphatic filariasis, onchocerciasis and loiasis are widespread neglected tropical diseases causing serious public health problems and impacting the socio-economic climate in endemic communities. More than 100 million people currently suffer from filarial infections but disease-related symptoms and infection-induced immune mechanisms are still ambiguous. Although most infected individuals have dominant Th2 and regulatory immune responses leading to a homeostatic regulated state, filarial-induced overt pathology like lymphedema, dermal pathologies or blindness can occur...
June 22, 2018: Parasitology Research
Yuri S Tokarev, Katy M Peat, Julia M Malysh, Igor V Senderskiy
A microsporidium was found in a Mediterranean cricket Gryllus bimaculatus from a pet market in the UK and a lab stock at the Moscow Zoo (originating from London Zoo). The spores were ovoid, uninucleate, 6.3 × 3.7 μm in size (unfixed), in packets by of 8, 16, or 32. The spores were easily discharged upon dessication or slight mechanical pressure. The polar tube was isofilar, with 15-16 coils arranged in 1-2 rows. The polaroplast was composed of thin lamellae and occupied about one third of the spore volume...
June 21, 2018: Parasitology Research
Nicole Brand Ederli, Samira Salim Mello Gallo, Luana Castro Oliveira, Francisco Carlos Rodrigues de Oliveira
Nematodes of the genus Physaloptera are common in rodents, including in species of the Family Cricetidae. There is no report of nematodes parasitizing Cerradomys goytaca, so this is the first one. For this study, 16 rodents were captured in the city of Quissamã, in the northern of Rio de Janeiro State. The rodents were necropsied, and the digestive tracts were analyzed under a stereomicroscope for the presence of parasites. The nematodes were fixed in hot AFA, clarified in Amann's lactophenol, mounted on slides with coverslip, and observed under an optical microscope...
June 20, 2018: Parasitology Research
Ana Paula Braga Lima, Maykon Tavares de Oliveira, Rafael Rodrigues Silva, Rosália Morais Torres, Vanja Maria Veloso, Marta de Lana, Glenda Nicioli da Silva
Chagas disease, caused by the protozoan Trypanosoma cruzi, is considered to be a multifactorial disease associated with host and parasite genetics, which influence clinical aspects of the disease and other host conditions. In order to understand better the evolution of the disease, this study intended to evaluation of parasite and host genetics in two generations of a family with Chagas disease from the Alto Paranaiba region, Minas Gerais, Brazil, comprising a mother and her five daughters. Several features were evaluated, including the characterization of T...
June 19, 2018: Parasitology Research
Qing Liu, Wen-Wei Gao, Hany M Elsheikha, Jun-Jun He, Fa-Cai Li, Wen-Bin Yang, Xing-Quan Zhu
Growth and replication of the protozoan parasite Toxoplasma gondii within host cell entail the production of several effector proteins, which the parasite exploits for counteracting the host's immune response. Despite considerable research to define the host signaling pathways manipulated by T. gondii and their effectors, there has been limited progress into understanding how individual members of the dense granule proteins (GRAs) modulate gene expression within host cells. The aim of this study was to evaluate whether T...
June 19, 2018: Parasitology Research
Gérald Umhang, Frédéric Grenouillet, Vanessa Bastid, Selim M'Rad, Benoît Valot, Myriam Oudni-M'Rad, Hamouda Babba, Franck Boué
Cystic echinococcosis is a zoonotic disease with worldwide distribution caused by the larval stage of the Cestode parasite Echinococcus granulosus sensu lato. Due to the predominance or even the exclusive presence of E. granulosus sensu stricto (s.s.) among E. granulosus species in many areas, the genetic diversity needs to be further investigated at the species level to better understand the inter- and intra-focus epidemiological features. Short sequences of mitochondrial or nuclear genes generally lack or have limited discriminatory power, hindering the detection of polymorphisms to reflect geographically based peculiarities and/or any history of infection...
June 18, 2018: Parasitology Research
Guadalupe Núñez, Nelly Villalobos, Cinthia P Herrera, José Navarrete-Perea, Adriana Méndez, José J Martinez-Maya, Raúl J Bobes, Gladis Fragoso, Edda Sciutto, Laura Aguilar, Irene P Del Arenal
Taeniasis-cysticercosis, a zoonosis caused by Taenia solium, is prevalent in underdeveloped countries, where marginalization promotes its continued transmission. Pig cysticercosis, an essential stage for transmission, is preventable by vaccination. An efficient multiepitope vaccine against pig cysticercosis, S3Pvac, was developed. Previous studies showed that antibodies against one of the S3Pvac components, GK-1, are capable of damaging T. solium cysticerci, inhibiting their ability to transform into the adult stage in golden hamster gut...
June 6, 2018: Parasitology Research
Ikuko Makino, Mizue Inumaru, Niichiro Abe, Yukita Sato
A 1-month-old brown wood owlet (Strix leptogrammica) purchased from a wholesaler and housed as a companion bird by an individual owner in Japan showed severe dehydration and anorexia following a week of vomiting and severe diarrhea. A great number of approximately 5 × 4-μm-sized Cryptosporidium oocysts were found in the feces by microscopy. The owlet was administered subcutaneous fluid and intragastric tube feeding for 2 weeks, resulting in improvement of the condition with a decreased number of oocysts in the feces...
June 6, 2018: Parasitology Research
Myoung-Ro Lee, Won Gi Yoo, Yu Jung Kim, Eun Ju Chung, Shin-Hyeong Cho, Jung-Won Ju
Venom allergen-like (VAL) proteins are important to host-parasite interactions. We previously demonstrated that a Clonorchis sinensis VAL (CsVAL) protein-derived synthetic peptide suppresses allergic and inflammatory responses. However, little is known regarding the physicochemical and antigenic properties of CsVAL proteins. Here, we identified a novel 194 amino acid VAL protein, named C. sinensis VAL 28 (CsVAL28), and characterized its functional motifs and structural details as a new member of the CAP superfamily...
June 6, 2018: Parasitology Research
Arutchelvan Rajamanikam, Suresh Kumar, Chandramathi Samudi, Madhav Kudva
Blastocystis sp. is a gastrointestinal (GI) protozoan parasite reported to cause non-specific GI symptoms including diarrhea, flatulence, abdominal pain, and nausea. Complete eradication of Blastocystis sp. is rather challenging even with the drug of choice, i.e., metronidazole. Here, we report on two Blastocystis sp.-infected individuals, who presented increased parasite load and exacerbated symptoms upon treatment with the usual recommended dosage and regime of metronidazole. The two studies uniquely demonstrate for the first time a cyst count as high as fivefold more than the original cyst count before treatment and show an exacerbation of GI symptoms despite treatment...
June 5, 2018: Parasitology Research
Jesus Díaz-Rodríguez, David Donaire-Barroso, Michael J Jowers
In this study, we report, through molecular identification, the first African records of a digenean trematode parasite of the genus Euryhelmis. We recovered metacercariae encysted in an anuran, the endemic Moroccan painted frog (Discoglossus scovazzi), and a vulnerable caudate, the North African fire salamander (Salamandra algira), from four localities in North Africa (Morocco). Our records go back to the past century and have been confirmed in successive fieldwork seasons thereafter. Metacercarial stages of these parasites require amphibians as the last intermediate host, but the exact identity of the primary hosts and predators of the infected animals in Africa remain unknown...
June 2, 2018: Parasitology Research
Samira Muñoz-Cruz, Argelia Gomez-García, Félix Matadamas-Martínez, Juan A Alvarado-Torres, Patricia Meza-Cervantez, Lourdes Arriaga-Pizano, Lilián Yépez-Mulia
Mast cells play a central role in the early clearance of the intestinal parasite Giardia lamblia. In a previous study, we reported that G. lamblia live trophozoites or trophozoite-derived total soluble extract induced direct activation (IgE-independent) of mast cells and release of IL-6 and TNF-α. To identify the Giardia molecules and the mast cell receptors involved in this activation, trophozoite-derived total soluble proteins separated into three fractions (F1-F3) were evaluated for its ability to activate mast cells in vitro...
June 2, 2018: Parasitology Research
Z Rezaei, B Sarkari, M Dehghani, A Layegh Gigloo, M Afrashteh
Visceral leishmaniasis (VL) is a major health concern in patients with HIV infection in endemic areas of VL. In these areas, a substantial number of infected individuals are asymptomatic and the risk of acute VL infection in HIV/VL co-infected cases is high. The current study aimed to determine the prevalence of asymptomatic VL infection among HIV-infected patients in Fars province, southern Iran. Subjects of the study were 251 HIV-confirmed patients who all were clinically asymptomatic for leishmaniasis. Blood samples were obtained from each participant...
June 2, 2018: Parasitology Research
Lakkhana Sadaow, Oranuch Sanpool, Issarapong Phosuk, Rutchanee Rodpai, Tongjit Thanchomnang, Adulsak Wijit, Witthaya Anamnart, Sakhone Laymanivong, Win Pa Pa Aung, Penchom Janwan, Wanchai Maleewong, Pewpan M Intapan
Ascaris lumbricoides is the largest roundworm known from the human intestine while Ascaris suum is an internal parasite of pigs. Ascariasis, caused by Ascaris lumbricoides, has a worldwide distribution. Here, we have provided the first molecular identification of Ascaris eggs and adults recovered from humans and pigs in Thailand, Lao PDR, and Myanmar. We amplified and sequenced nuclear ribosomal DNA (ITS1 and ITS2 regions) and mitochondrial DNA (cox1 gene). Sequence chromatograms of PCR-amplified ITS1 region revealed a probable hybrid genotype from two human ascariasis cases from Chiang Mai Province, northern Thailand...
June 2, 2018: Parasitology Research
Hyun Beom Song, Bong-Kwang Jung, Jin Hyoung Kim, Young-Ha Lee, Min-Ho Choi, Jeong Hun Kim
The conversion of tachyzoites into bradyzoites is a way for Toxoplasma gondii to establish a chronic and asymptomatic infection and achieve lifelong persistence in the host. The bradyzoites form tissue cysts in the retina, but not much is known about the horizontal distribution of the cysts or their interactions with glial cells in the retina. A chronic ocular toxoplasmosis model was induced by per oral administration of T. gondii Me49 strain cysts to BALB/c mice. Two months after the infection, retinas were flat-mounted and immunostained to detect cysts, ganglion cells, Müller cells, astrocytes, and microglial cells, followed by observation under fluorescence and confocal microscope...
June 2, 2018: Parasitology Research
Maria Paola Maurelli, Antonio Bosco, Paola Pepe, Davide Ianniello, Alessandra Amadesi, Giuseppe Cringoli, Laura Rinaldi
The aim of this study was to develop and validate an innovative protocol for the diagnosis of Echinococcus granulosus and other Taeniidae in dogs. For this purpose, three experiments were performed, using faecal samples from naturally infected dogs. Firstly, the FLOTAC technique was calibrated with five flotation solutions: saturated sodium chloride (specific gravity, s.g. = 1.20), zinc sulphate (s.g. = 1.35), zinc chloride (s.g. = 1.45), Breza (s.g. = 1.30) and modified Breza (s.g. = 1...
June 2, 2018: Parasitology Research
G L Ataev, A S Tokmakova
The localisation and the composition of germinal material in miracidia and mother sporocysts of Echinostoma caproni were studied with the use of histological and electron microscopic methods. Germinal material in miracidia was localised in the posterior body half and was represented by 3-4 undifferentiated cells and 5-7 germinal cells. Taken together, these cells are referred to as the primordium of the germinal mass. In the mother sporocyst, germinal elements also form and develop in the germinal mass, which is located caudally...
June 1, 2018: Parasitology Research
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