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Journal of Korean Medical Science

Jong-Hun Kim, Mina Ha
Background: Residential radon exposure is known to be an important risk factor for the development of lung cancer. The objective of this study was to calculate the disease burden of lung cancer attributable to residential radon exposure in Korea. Methods: We calculated the national exposure level using Korean national radon survey data from 2011 to 2014, and house structure distribution data from each administrative region. Using the exposure-risk function, the population attributable fraction (PAF) was calculated and applied to calculate the disease burden for lung cancer attributable to residential radon exposure...
July 16, 2018: Journal of Korean Medical Science
Hyungryul Lim, Jonghyuk Choi, Jong-Hun Kim, Hae-Kwan Cheong, Mina Ha
Background: Radiation exposure from medical procedures has been rapidly increasing. We purposed to estimate the fraction of cancer incidence and mortality attributed to diagnostic medical radiation exposure in Korea. Methods: Using information on diagnostic medical radiation exposure from various sources including national health examination (National Health Insurance Service), private health examination, and conscription health examination; the annual mean exposed organ dose (mGy) from all diagnostic medical radiation use, grouped by sex and 5-year age ranges up to 80 years, was calculated...
July 16, 2018: Journal of Korean Medical Science
Young Woo Jin, Songwon Seo
No abstract text is available yet for this article.
July 16, 2018: Journal of Korean Medical Science
Jung Ran Choi, Sang Baek Koh, Hye Ryun Kim, Hyojin Lee, Dae Ryong Kang
Background: Lung cancer in never smokers (LCINS) differs etiologically and clinically from lung cancer attributed to smoking. After smoking, radon exposure is the second leading cause and the primary risk factor of lung cancer among never smokers. Exposure to radon can lead to genetic and epigenetic alterations in tumor genomes affecting genes and pathways involved in lung cancer development. The present study sought to explore genetic alterations associated with LCINS exposed to radon gas indoors...
July 16, 2018: Journal of Korean Medical Science
Shinje Moon, Jung Hwan Park, Eun-Jung Jang, Yoo-Kyung Park, Jae Myung Yu, Joon-Sung Park, Youhern Ahn, Sung-Hee Choi, Hyung Joon Yoo
Background: This study aimed to identify the gender-specific characteristics of the surrogate measures of insulin resistance and to establish valid cut-off values for metabolic abnormalities in a representative sample in Korea. Methods: Data were collected from the datasets of the Korean National Health and Nutrition Examination Survey between 2007 and 2010. The total number of eligible participants was 10,997. We used three measures of insulin resistance: the homeostasis model assessment-insulin resistance (HOMA-IR), McAuley index, and triglyceride and glucose (TyG) index...
July 16, 2018: Journal of Korean Medical Science
Dong Sun Kim
No abstract text is available yet for this article.
July 16, 2018: Journal of Korean Medical Science
Durga Prasanna Misra, Anupam Wakhlu, Vikas Agarwal
No abstract text is available yet for this article.
July 9, 2018: Journal of Korean Medical Science
Ji Min Cha, Ji Eun Kim, Min A Kim, Boyoung Shim, Myeong Jin Cha, Jung Jae Lee, Doug Hyun Han, Un Sun Chung
Background: The purpose of this study was to examine post-traumatic stress, depression, anxiety, and complicated grief in Korean high school students who experienced a peer suicide. Methods: A total of 956 students were included in the statistical analysis. One week after a peer suicide, a school-based crisis intervention program was conducted. The cohort was followed-up at one week and five months after a peer suicide. The program consists of screening tests, educational sessions, and further interview with psychiatric specialists for the selected group...
July 9, 2018: Journal of Korean Medical Science
Seung Eun Lee, Sun-Whe Kim, Ho-Seong Han, Woo Jung Lee, Dong-Sup Yoon, Baik-Hwan Cho, In Seok Choi, Hyun Jong Kim, Soon-Chan Hong, Sang-Mok Lee, Dong Wook Choi, Sang-Jae Park, Hong-Jin Kim, Jin-Young Jang
Background: Although all guidelines suggest that T2 gallbladder (GB) cancer should be treated by extended cholecystectomy (ECx), high-level scientific evidence is lacking because there has been no randomized controlled trial on GB cancer. Methods: A nationwide multicenter study between 2000 and 2009 from 14 university hospitals enrolled a total of 410 patients with T2 GB cancer. The clinicopathologic findings and long-term follow-up results were analyzed after consensus meeting of Korean Pancreas Surgery Club...
July 9, 2018: Journal of Korean Medical Science
Woong-Woo Lee, Beomseok Jeon, Ryul Kim
Previously, we defined DRD as a syndrome of selective nigrostriatal dopamine deficiency caused by genetic defects in the dopamine synthetic pathway without nigral cell loss. DRD-plus also has the same etiologic background with DRD, but DRD-plus patients have more severe features that are not seen in DRD because of the severity of the genetic defect. However, there have been many reports of dystonia responsive to dopaminergic drugs that do not fit into DRD or DRD-plus (genetic defects in the dopamine synthetic pathway without nigral cell loss)...
July 9, 2018: Journal of Korean Medical Science
Ji Won Choi, Duk Kyung Kim, Sang Hyun Lee, Hyun Su Shin, Bong Gyu Seong
Background: Despite expanding demands for non-operating room anesthesia (NORA) worldwide, studies in this field are scarce. We compared the overall characteristics and the nature of deaths occurring within 48 hours after surgery between NORA and operating room anesthesia (ORA) cases at a Korean tertiary hospital. Methods: We retrospectively analyzed the medical records of patients who underwent surgical procedures under anesthesia services in and outside the operating room from January 2013 to November 2017...
July 9, 2018: Journal of Korean Medical Science
Shin Ha, Seok-Jun Yoon, Byung Chul Chun, Kyeong Jin Kim, Seung-Young Roh, Eun Joo Lee, Won Ho Kim, Sin Gon Kim, Yo Han Lee
The aim of our work was to analyze the bibliographical characteristics of 9 North Korean medical journals and articles. All journals show only ten pieces of information, such as publication dates and table of contents, and do not provide submission guidelines and journal policy. Most of the journals were published four times a year. Editorials often share government policy. Research articles are very short and compressed. The journals often publish articles on oriental medicine and medical information useful to the public...
July 2, 2018: Journal of Korean Medical Science
Sung-Tae Hong
No abstract text is available yet for this article.
July 2, 2018: Journal of Korean Medical Science
Eben Jung, Sunae Ryu, Zewon Park, Jong-Gu Lee, Jung-Yeon Yi, Doo Won Seo, Juhyun Lee, Ho-Sang Jeong, Jeong Mi Kim, Woo-Yong Oh
Background: Carvedilol is commonly used to treat hypertension as a β- and α1 -adrenoreceptor blocker, but it is metabolized by CYP2D6, and CYP2D6* 10 allele is dominant in Asian population. The objective of this study was to assess the influence of CYP2D6 polymorphisms on the pharmacokinetic (PK) and pharmacodynamic (PD) characteristics of carvedilol in healthy Korean volunteers. Methods: A PK/PD study for a single and multiple dosing of carvedilol were conducted...
July 2, 2018: Journal of Korean Medical Science
Ji Yoon Kwak, Kyu-Ryong Choi, Roo Min Jun, Kyung Eun Han
Background: To analyze the results of court rulings about medical litigations related to cataract surgery in Korea. Methods: We collected 50 anonymized judgements regarding cataract surgery between 2000 and 2016 and analyzed the reasons for the medical litigations, the court rulings, the reasons for compensation, and the amount claimed and finally awarded. Results: Forty-eight litigations (96%) resulted from errors in treatment, and the reasons were as follows: endophthalmitis, dissatisfaction of visual outcome or ocular discomfort, bullous keratopathy or corneal opacity, retinal detachment, glaucoma or vitreous hemorrhage due to the progression of an underlying diabetic retinopathy, and others in order...
July 2, 2018: Journal of Korean Medical Science
Hyereen Kim, Bo Hyun Kim, Young Keum Kim, Jeong Mi Kim, Seo Young Oh, Eun Heui Kim, Min Jin Lee, Jong Ho Kim, Yun Kyung Jeon, Sang Soo Kim, Byung Joo Lee, Yong Ki Kim, In Joo Kim
Background: BRAF V600E mutation status and prevalence of non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) has not yet been reported in Korea. The aim of this study was to investigate the significance of the BRAF V600E mutation in the follicular variant of papillary thyroid carcinoma (FVPTC) and to determine the prevalence of NIFTP in BRAF V600E mutation-prevalent Korean patients. Methods: This study retrospectively analyzed 1,417 consecutive patients who underwent total thyroidectomy with routine prophylactic central lymph node dissection for papillary thyroid carcinoma (PTC)...
July 2, 2018: Journal of Korean Medical Science
Ji Tae Choung
The Korean society is rapidly aging and the health care needs for aged people are increasing. In this context, some physicians claim to establish new medical specialty board (MSB) for geriatric medical experts but also MSB for primary medical care specialists, clinical pharmacologists, and public health experts. In Korea, basic concept for the specialty board system is still under debates and the legal support for the system is poor. At present, doctors with MSBs in private sectors supply 92.4% of primary medical care but the National Health Care System requires more primary care physicians than specialists in Korea...
June 25, 2018: Journal of Korean Medical Science
Tae-Sung Yeum, Ung Gu Kang
Background: The aim of the study was to examine the characteristics of alpha wave peak frequency, power, and coherence in patients with schizophrenia. Methods: Thirty-one patients with schizophrenia and age- and sex-matched subjects with no psychopathology were enrolled. All study participants underwent quantitative electroencephalography (QEEG). Alpha-related values, including peak frequency, power, and coherence, were evaluated. Results: Alpha peak frequency on the Oz area was slower in the schizophrenia group than that in the control group...
June 25, 2018: Journal of Korean Medical Science
Do Jun Kim, Woo Jin Kim, Myoungnam Lim, Yoonki Hong, Seung-Joon Lee, Seok-Ho Hong, Jeongwon Heo, Hui-Young Lee, Seon-Sook Han
Background: Lung cancer is the most common cause of cancer-related mortality worldwide. We previously reported the identification of a new genetic marker, cellular retinoic acid binding protein 2 (CRABP2), in lung cancer tissues. The aim of this study was to assess plasma levels of CRABP2 from patients with non-small cell lung cancer (NSCLC). Methods: Blood samples that were collected from 122 patients with NSCLC between September 2009 and September 2013 were selected for the analysis, along with samples from age- (± 5 years), sex-, and cigarette smoking history (± 10 pack-years [PY])-matched controls from the Korea Biobank Network...
June 25, 2018: Journal of Korean Medical Science
Jung Ok Shim, Hye Ran Yang, Jin Soo Moon, Ju Young Chang, Jae Sung Ko, Sung Sup Park, Jeong Kee Seo
Background: Mutations in ATP7B cause Wilson disease (WD). However, direct DNA full sequencing cannot detect all mutations in patients with WD. Multiplex ligation-dependent probe amplification (MLPA) analysis is reportedly useful in increasing the diagnostic yield in other genetic disorders with large deletions or insertions. The aim of this study was to evaluate whether the detection rate of ATP7B mutations can be increased by using MLPA. Methods: We enrolled 114 children with WD from 104 unrelated families based on biochemical tests and direct DNA full sequencing...
June 25, 2018: Journal of Korean Medical Science
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