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Journal of Korean Medical Science

Jihei Cha, Han Wool Kim, Ji Hyen Lee, Soyoung Lee, Kyung-Hyo Kim
Background: Various pneumococcal vaccines have been evaluated for immunogenicity by opsonophagocytic assay (OPA). A multiplexed OPA (MOPA) for 13 pneumococcal serotypes was developed by Nahm and Burton, and expanded to 26 serotypes in 2012. The development of new conjugate vaccines with increased valence has necessitated expanded MOPAs to include these additional serotypes. In this study, we validated this expanded MOPA platform and applied to measure antibodies against 11 additional serotypes (2, 8, 9N, 10A, 11A, 12F, 15B, 17F, 20B, 22F, and 33F) in human sera...
December 17, 2018: Journal of Korean Medical Science
Doukyoung Chon, Yunhwan Lee, Jinhee Kim, Kyung-Eun Lee
Background: The trend of aging society is occurring globally, and with it, one of the health problems that is emerging is frailty. Efforts are being made to account for the increasing prevalence of frailty, and various modifiable factors are being considered in regards to frailty. Because social contact has shown beneficial effects in terms of health in previous studies, it is increasingly being considered in relation to frailty. The purpose of this study was to assess the association of different types of social contact with frailty status...
December 17, 2018: Journal of Korean Medical Science
Jong Seo Yoon, Cheol Hwan So, Hae Sang Lee, Jung Sub Lim, Jin Soon Hwang
Background: Brain magnetic resonance imaging (MRI) is routinely performed to identify brain lesions in girls with central precocious puberty (CPP). We aimed to investigate the prevalence and type of brain lesions among Korean girls with CPP and evaluate the need for routine brain MRI examinations. Methods: This retrospective cross-sectional study evaluated data on 3,528 girls diagnosed with CPP from April 2003 to December 2016, and identified 317 girls who underwent sellar MRI...
December 17, 2018: Journal of Korean Medical Science
Yu Jin Lee, Seung-Sik Hwang, Sang Do Shin, Seung Chul Lee, Kyoung Jun Song
Background: In cardiac arrest, the survival rate increases with the provision of bystander cardiopulmonary resuscitation (CPR), of which the initial response and treatment are critical. Telephone CPR is among the effective methods that might increase the provision of bystander CPR. This study aimed to describe and examine the improvement of neurological outcomes in individuals with out-of-hospital acute cardiac arrest by implementing the nationwide, standardized telephone CPR program...
December 17, 2018: Journal of Korean Medical Science
Myung Soo Kim, Ho Seok Chung, Eu Chang Hwang, Seung Il Jung, Dong Deuk Kwon, Jun Eul Hwang, Woo Kyun Bae, Jae Young Park, Chang Wook Jeong, Cheol Kwak, Cheryn Song, Seong Il Seo, Seok-Soo Byun, Sung-Hoo Hong, Jinsoo Chung
Background: To evaluate survival outcomes and prognostic factors for overall survival (OS) in patients with metastatic renal cell carcinoma (mRCC) who received sunitinib (SU) and pazopanib (PZ) as first-line therapy in real-world Korean clinical practice. Methods: Data of 554 patients with mRCC who received SU or PZ at eight institutions between 2012 and 2016 were retrospectively reviewed. Based on the targeted therapy, the patients were divided into SU (n = 293) or PZ (n = 261) groups, and the clinicopathological variables and survival rates of the two groups were compared...
December 17, 2018: Journal of Korean Medical Science
Jeana Hong, Seak Hee Oh, Han-Wook Yoo, Hiroshi Nittono, Akihiko Kimura, Kyung Mo Kim
Oxysterol 7α-hydroxylase deficiency is a very rare liver disease categorized as inborn errors of bile acid synthesis, caused by CYP7B1 mutations. As it may cause rapid progression to end-stage liver disease even in early infancy, a high index of suspicion is required to prevent fatal outcomes. We describe the case of a 3-month-old boy with progressive cholestatic hepatitis and severe hepatic fibrosis. After excluding other etiologies for his early liver failure, we found that he had profuse urinary excretion of 3β-monohydroxy-Δ5 -bile acid derivatives by gas chromatography/mass spectrometry analysis with dried urine spots on filter paper...
December 17, 2018: Journal of Korean Medical Science
Seong Hee Kang, Moon Young Kim, Soon Koo Baik
No abstract text is available yet for this article.
December 10, 2018: Journal of Korean Medical Science
Mi-Im Kim, Jaesook Oh, Won Hyun Cho, Dong-Sik Kim, Cheol Woong Jung, Young-Dong You, Jun-Gyo Gwon, Jae-Myeong Lee
Background: This retrospective study analyzed the causes of failure in the management process from the identification of brain-dead potential organ donors to actual donation in Korea over the past 5 years. Methods: Data of 8,120 potential brain deaths reported to the Korea Organ Donation Agency were used, including information received at the time of reporting, donation suitability evaluation performed by the coordinator after the report, and data obtained from interviews of hospital medical staff and the donor's family...
December 10, 2018: Journal of Korean Medical Science
Won Suk Choi, Su Hyun Kim, Dae Won Park
Background: Pertussis is highly contagious respiratory disease. Healthcare workers (HCWs) can be an important mediator of the disease. A seroprevalence of pertussis was investigated in HCWs to determine the immune status against pertussis and to detect the unidentified pertussis. Methods: This study was conducted for HCWs at a hospital located in Korea in 2011. After obtaining written informed consent for HCWs voluntarily participating in the study, 10 mL of blood was collected from each subject...
December 10, 2018: Journal of Korean Medical Science
Ji Hyun Moon, Mi Hee Kong, Hyeon Ju Kim
Background: Muscle mass and muscle function are related to depressed mood in studies of adults. Like adults, Korean students are highly likely to suffer from decreased muscle mass due to social conditions. In this study, we evaluated the muscle mass status of Korean adolescents and assess the effect of muscle on depressive mood. Methods: A total of 1,233 adolescent boys and girls participants from the Korea National Health and Nutrition Examination Survey were enrolled in our study...
December 10, 2018: Journal of Korean Medical Science
Kye-Hyung Kim, Myung Jin Lee, Mee Kyung Ko, Eun Yup Lee, Jongyoun Yi
The incidence of severe fever with thrombocytopenia syndrome (SFTS) has increased in Korea since a first report in 2013. We investigated whether SFTS existed before 2013 using real-time reverse transcription polymerase chain reaction and stored blood samples from febrile patients with thrombocytopenia. Four cases of SFTS were identified, with the earliest occurring in 2008.
December 10, 2018: Journal of Korean Medical Science
Hyun-Seung Lee, Yeon Hee Kim, Ho-Seok Kwak, Jung-Yeol Han, Sun-Jin Jo, Hae Kook Lee
Background: In this prospective cohort study, we investigated the association between fatty acid ethyl esters (FAEEs) in meconium as biomarkers of prenatal ethanol exposure and growth deficits, as birth outcomes, that constitute several of the key cardinal features of fetal alcohol syndrome. Methods: A total of 157 meconium samples were collected from enrolled infants within 24 hours of birth, and nine FAEEs were quantified using liquid chromatography/tandem mass spectrometry...
December 10, 2018: Journal of Korean Medical Science
Jae Yoon Jeong, Sanghyeok Lim, Joo Hyun Sohn, Jae Gon Lee, Dae Won Jun, Yongsoo Kim
Background: Sarcopenia is associated with a poor prognosis in patients with liver cirrhosis. However, it is not known whether the rate of skeletal muscle depletion is also associated with a poor prognosis. We investigated the prognostic impact of the rate of skeletal muscle depletion in patients with liver cirrhosis. Methods: We included retrospectively all patients with liver cirrhosis who underwent both multiple computed tomography scans and hepatic venous pressure gradient (HVPG) measurements...
December 10, 2018: Journal of Korean Medical Science
Min Sun Kim, Jihye Lee, Jin-Ah Sim, Jung Hye Kwon, Eun Joo Kang, Yu Jung Kim, Junglim Lee, Eun-Kee Song, Jung Hun Kang, Eun Mi Nam, Si-Young Kim, Hwan-Jung Yun, Kyung Hae Jung, June Dong Park, Young Ho Yun
Background: It is difficult to decide whether to inform the child of the incurable illness. We investigated attitudes of the general population and physicians toward prognosis disclosure to children and associated factors in Korea. Methods: Physicians working in one of 13 university hospitals or the National Cancer Center and members of the general public responded to the questionnaire. The questionnaire consisted of the age appropriate for informing children about the prognosis and the reason why children should not be informed...
December 3, 2018: Journal of Korean Medical Science
Seil Oh, June-Soo Kim, Yong-Seog Oh, Dong-Gu Shin, Hui-Nam Pak, Gyo-Seung Hwang, Kee-Joon Choi, Jin-Bae Kim, Man-Young Lee, Hyung-Wook Park, Dae-Kyeong Kim, Eun-Sun Jin, Jaeseok Park, Il-Young Oh, Dae-Hee Shin, Hyoung-Seob Park, Jun Hyung Kim, Nam-Ho Kim, Min-Soo Ahn, Bo-Jeong Seo, Young-Joo Kim, Seongsik Kang, Juneyoung Lee, Young-Hoon Kim
Background: Vitamin K antagonist (VKA) to prevent thromboembolism in non-valvular atrial fibrillation (NVAF) patients has limitations such as drug interaction. This study investigated the clinical characteristics of Korean patients treated with VKA for stroke prevention and assessed quality of VKA therapy and treatment satisfaction. Methods: We conducted a multicenter, prospective, non-interventional study. Patients with CHADS2 ≥ 1 and treated with VKA (started within the last 3 months) were enrolled from April 2013 to March 2014...
December 3, 2018: Journal of Korean Medical Science
Jin-Hong Yoo
No abstract text is available yet for this article.
December 3, 2018: Journal of Korean Medical Science
Hyun-Jin Han, Jong-Hun Kim, Soo-Eun Chung, Jae-Hyun Park, Hae-Kwan Cheong
Background: Despite its growing significance, studies on the burden of disease associated with natural disasters from the perspective of public health were few. This study aimed at estimating the national burden of disease associated with typhoons and torrential rains in Korea. Methods: During the period of 2002-2012, 11 typhoons and five torrential rains were selected. Mortality and morbidities were defined as accentual death, injury and injury-related infection, and mental health...
December 3, 2018: Journal of Korean Medical Science
Tina Didari, Mohammad Abdollahi
No abstract text is available yet for this article.
December 3, 2018: Journal of Korean Medical Science
Bongyoung Kim, Rangmi Myung, Jieun Kim, Myoung-Jae Lee, Hyunjoo Pai
Background: Acute pyelonephritis (APN) is one of the most common community-acquired bacterial infections. Recent increases of antimicrobial resistance in urinary pathogens might have changed the other epidemiologic characteristics of APN. The objective of this study was to describe the current epidemiology of APN in Korea, using the entire population. Methods: From the claims database of the Health Insurance Review and Assessment Service in Korea, the patients with International Classification of Diseases, 10th Revision codes N10 (acute tubulo-interstitial nephritis) or N12 (tubulo-interstitial nephritis, neither acute nor chronic) as the primary discharge diagnosis during 2010-2014 were analyzed, with two or more claims during a 14-day period considered as a single episode...
December 3, 2018: Journal of Korean Medical Science
Jong-Seo Yoon, Won Kyoung Jhang, Yu Hyeon Choi, Bongjin Lee, Yoon Hee Kim, Hwa Jin Cho, Byung Wook Eun, Jintae Kim, Kyung Won Kim, Joongbum Cho, Hong Ju Shin, Jeong Min Ryu, Jae Hee Chung, Young Yoo, June Huh, Seong Jong Park, June Dong Park
Background: The aim of this study was to describe the structure, organization, management, and staffing of pediatric critical care (PCC) in Korea. Methods: We directed a questionnaire survey for all Upper Grade General Hospitals (n = 43) in Korea in 2015. The first questionnaire was mainly about structure, organization, and staffing and responses were obtained from 32 hospitals. The second questionnaire was mainly about patients and management. Responses to second questionnaire were obtained from 18 hospitals...
December 3, 2018: Journal of Korean Medical Science
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