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Epilepsy Research

Guohui Jiang, Pu Tianqiang, Zhimin Li, Xiaodong Zhang, Ruijiao Zhou, Xing Cao, JuminG Yu, Xiaoming Wang
No abstract text is available yet for this article.
January 10, 2019: Epilepsy Research
A Thelengana, Garima Shukla, Achal Srivastava, Mamta Bhushan Singh, Anupama Gupta, Roopa Rajan, Deepti Vibha, Awadh Kishor Pandit, Kameshwar Prasad
OBJECTIVE: There is limited literature on cognitive, behaviour and sleep-related adverse effects of levetiracetam and oxcarbazepine among adult epilepsy patients, except for what is available from the initial efficacy trials. This study was initiated with the aim to evaluate the incidence and prevalence of various cognitive, behaviour and sleep-related adverse effects of levetiracetam versus oxcarbazepine among people with epilepsy. METHODS: The study was conducted in two parts: part A was a cross-sectional study, and part B was a longitudinal study...
January 8, 2019: Epilepsy Research
Riikka Immonen, Gregory Smith, Rhys D Brady, David Wright, Leigh Johnston, Neil G Harris, Eppu Manninen, Raimo Salo, Craig Branch, Dominique Duncan, Ryan Cabeen, Xavier Ekolle Ndode-Ekane, Cesar Santana Gomez, Pablo M Casillas-Espinosa, Idrish Ali, Sandy R Shultz, Pedro Andrade, Noora Puhakka, Richard J Staba, Terence J O'Brien, Arthur W Toga, Asla Pitkänen, Olli Gröhn
Preclinical imaging studies of posttraumatic epileptogenesis (PTE) have largely been proof-of-concept studies with limited animal numbers, and thus lack the statistical power for biomarker discovery. Epilepsy Bioinformatics Study for Antiepileptogenic Therapy (EpiBioS4Rx) is a pioneering multicenter trial investigating preclinical imaging biomarkers of PTE. EpiBios4Rx faced the issue of harmonizing the magnetic resonance imaging (MRI) procedures and imaging data metrics prior to its execution. We present here the harmonization process between three preclinical MRI facilities at the University of Eastern Finland (UEF), the University of Melbourne (Melbourne), and the University of California, Los Angeles (UCLA), and evaluate the uniformity of the obtained MRI data...
January 7, 2019: Epilepsy Research
Christelle Rodrigues, Catherine Chiron, Marwa Ounissi, Olivier Dulac, Ségolène Gaillard, Rima Nabbout, Vincent Jullien
Vigabatrin is indicated as adjunctive therapy for refractory focal seizures. For children, European recommendations indicate maintenance doses varying from 30 to 100 mg/kg/day for this indication. Since cumulated dose was associated with retinal toxicity, it is essential to administrate the lowest effective dose to patients. This work was conducted with the purpose to determine the pediatric doses of vigabatrin that allow a similar exposure than effective doses in adults (2-3 g/day) through a pharmacokinetic (PK) study, using both pediatric and adult data...
January 7, 2019: Epilepsy Research
Mumin Alper Erdogan, Dimas Yusuf, Arife Erdogan, Oytun Erbas
BACKGROUND: Millions of individuals worldwide suffer from epilepsy, and up to 25% of patients have seizures that are resistant to currently available antiepileptic drugs. Hence, there continues to be a need for more seizure medications that are effective yet tolerable. Levodropropizine (LVDP) is an established antitussive drug that, based on preclinical data, may also have antiepileptic activity. METHODS: We treated rats with either intraperitoneal (IP) LVDP at two different doses or placebo in randomized fashion and then exposed them to IP pentylenetetrazol (PTZ), a potent seizure-inducing compound...
December 29, 2018: Epilepsy Research
Medine I Gulcebi, Tansel Kendirli, Zehra Asik Turgan, Philip N Patsalos, Yilmaz Filiz Onat
No abstract text is available yet for this article.
December 28, 2018: Epilepsy Research
Robert Ciszek, Xavier Ekolle Ndode-Ekane, Cesar Santana Gomez, Pablo M Casillas-Espinosa, Idrish Ali, Gregory Smith, Noora Puhakka, Niina Lapinlampi, Pedro Andrade, Alaa Kamnaksh, Riikka Immonen, Tomi Paananen, Matthew R Hudson, Rhys D Brady, Sandy R Shultz, Terence J O'Brien, Richard J Staba, Jussi Tohka, Asla Pitkänen
The Epilepsy Bioinformatics Study for Antiepileptogenic Therapy (EpiBioS4Rx) is a National Institutes for Neurological Diseases and Stoke funded Centers-Without-Walls international multidisciplinary study aimed at preventing epileptogenesis. The preclinical biomarker discovery in EpiBios4Rx applies a multicenter study design to allow the number of animals that are required for adequate statistical power for the analysis to be studied in an efficient manner. Further, the use of multiple centers mimics the clinical trial situation, and therefore potentially the chance of successful clinical translation of the outcomes of the study...
December 27, 2018: Epilepsy Research
Reza Basiri, Aidin Shariatzadeh, Samuel Wiebe, Yahya Aghakhani
OBJECTIVE: Interictal epileptiform discharges (IEDs) are important to identify the epileptogenic zone and to define epileptic syndromes. However, not all patients show IEDs on scalp EEG. We evaluate the likelihood of not findings spikes on prolonged Video-EEG Monitoring (VEM) in patients with focal epilepsy, and explore clinical correlates. METHODS: We retrospectively reviewed the VEM reports for all the patients admitted to the seizure monitoring unit in the Calgary Epilepsy Program between July'10 and August'17...
December 24, 2018: Epilepsy Research
Julia Scholly, Francesca Pizzo, Alexander Timofeev, Maria Paola Valenti-Hirsch, Irène Ollivier, François Proust, Nicolas Roehri, Christian-George Bénar, Edouard Hirsch, Fabrice Bartolomei
OBJECTIVE: Epilepsy associated with periventricular nodular heterotopia (PNH) is characterized by complex relationships between the heterotopic and the normotopic cortex during the interictal state and at seizure onset. High-frequency oscillations (HFO) have been proposed as a marker of epileptogenicity that might reflect disease activity. The effects of thermocoagulations on epileptogenicity in this context remain unknown. We aimed to investigate the interictal HFO- and spike profiles of different cortical structures before and after two consecutive SEEG-guided thermocoagulations, in correlation with seizure outcome, in a patient with PNH-related drug-resistant epilepsy...
December 15, 2018: Epilepsy Research
Vikas Kumar, Chandra Prakash, Rameshwar Singh, Deepak Sharma
The present study was carried out to evaluate: the antiepileptic effect of dietary curcumin, and the effect of epileptic state and curcumin on the molecular expression of voltage-activated Na+ channel subtypes Nav 1.1 and Nav 1.6 in the iron-induced experimental epilepsy in the rat. Rats were divided into four groups; Group I (control rats), Group II (epileptic rats), Group III (curcumin-fed epileptic rats), and Group IV (curcumin-fed rats). Curcumin was fed chronically to rats approximately at the dose of 100 mg/kg body wt...
December 15, 2018: Epilepsy Research
Barry E Gidal, Jim Ferry, Antonio Laurenza, Takashi Ueno
Plasma protein binding and effects on volume of distribution and pharmacologically active, circulating-drug concentrations are complex issues. Protein-binding displacement often underlies drug-drug interactions. Perampanel is a once-daily oral anti-seizure drug for focal seizures and primary generalized tonic-clonic seizures. Perampanel is also indicated for monotherapy use for focal seizures in the United States. Perampanel is extensively but slowly metabolized via CYP3A4. Its elimination t½ is about 100 h, and it displays substantial plasma protein binding (>95%)...
December 12, 2018: Epilepsy Research
Irene Aicua-Rapun, Pascal André, Andrea O Rossetti, Laurent A Decosterd, Thierry Buclin, Jan Novy
Brivaracetam is available in intravenous formulation, and its favourable pharmacokinetic profile makes it a promising agent in the treatment of status epilepticus (SE). Its availability as an intravenous formulation and its favourable pharmacokinetic profile make it a promising agent in the treatment of status epilepticus. Our aim was to assess the correlation between BRV exposure and clinical response. We retrospectively studied all consecutive SE patients treated with BRV in our centre from September 2016 to March 2018...
December 3, 2018: Epilepsy Research
Seyede Nastaran Momeni, Seyed Ali Masoud, Hamid Reza Banafshe
Vitamin D3 as a neuroactive steroid hormone plays an important role in the nervous system. Recent clinical and experimental studies have shown an association between vitamin D-related disorders and epilepsy. Therefore, this study was designed to examine the effects of chronic administration of vitamin D3 on pentylenetetrazole (PTZ)-induced seizure in mice. This interventional study was conducted on 120 mice in 12 groups. Two control groups acutely and chronically received a mixture of almond oil and paraffin; three groups were acutely given vitamin D3 at doses of 2000, 4000 and 6000 IU/kg; three groups chronically received vitamin D3 with similar doses for two weeks and two groups chronically and acutely received a sub-effective dose of vitamin D3 and diazepam...
November 28, 2018: Epilepsy Research
Alaa Kamnaksh, Noora Puhakka, Idrish Ali, Gregory Smith, Roxanne Aniceto, Jesse McCullough, Shalini Das Gupta, Xavier Ekolle Ndode-Ekane, Rhys Brady, Pablo Casillas-Espinosa, Matt Hudson, Cesar Santana-Gomez, Riikka Immonen, Pedro Andrade de Abreu, Nigel Jones, Sandy Shultz, Richard J Staba, Terence J O'Brien, Denes Agoston, Asla Pitkänen
The Epilepsy Bioinformatics Study for Antiepileptogenic Therapy (EpiBioS4Rx) is an international, multicenter, multidisciplinary study aimed at preventing epileptogenesis (EpiBioS4Rx: One of the study's major objectives is the discovery of diagnostic, prognostic, and predictive plasma protein and microRNA (miRNA) biomarkers that are sensitive, specific, and translatable to the human condition. Epilepsy due to structural brain abnormalities, secondary to neurological insults such as traumatic brain injury (TBI), currently represents ∼50% of all epilepsy cases...
November 26, 2018: Epilepsy Research
Achilleas Attilakos, Maria Tsirouda, Argiris Dinopoulos, Anastasia Garoufi
No abstract text is available yet for this article.
November 21, 2018: Epilepsy Research
Christina Pressl, Philip Brandner, Stefan Schaffelhofer, Karen Blackmon, Patricia Dugan, Manisha Holmes, Thomas Thesen, Ruben Kuzniecky, Orrin Devinsky, Winrich A Freiwald
There are no functional imaging based biomarkers for pharmacological treatment response in temporal lobe epilepsy (TLE). In this study, we investigated whether there is an association between resting state functional brain connectivity (RsFC) and seizure control in TLE. We screened a large database containing resting state functional magnetic resonance imaging (Rs-fMRI) data from 286 epilepsy patients. Patient medical records were screened for seizure characterization, EEG reports for lateralization and location of seizure foci to establish uniformity of seizure localization within patient groups...
November 17, 2018: Epilepsy Research
Charuta Joshi, Chelsey Stillman, Stephanie Criteser, Jennifer Oliver, Alison Conley, Stefan Sillau, Beth Zupec-Kania
OBJECTIVES: To retrospectively assess the incidence of high beta hydroxybutyrate, low bicarbonate (BIC), high acyl carnitine, low selenium, low magnesium, low zinc, low phosphorus, in a cohort of supplemented patients treated with the ketogenic diet (KD) for medically intractable epilepsy. To analyze effect of age, duration of exposure to KD, type of KD, and route of KD intake on lab abnormalities. To analyze the incidence of clinically actionable results, resulting in medical interventions based on abnormal results and to analyze costs of testing...
November 16, 2018: Epilepsy Research
Victor Navarrete-Modesto, Sandra Orozco-Suárez, Iris A Feria-Romero, Luisa Rocha
Epilepsy is associated with several epigenetic changes, such as DNA methylation, histone modification, and alterations in the synthesis and functioning of non-coding RNAs (ncRNAs). Paradoxically, antiepileptic drugs (AEDs) that are widely used to control epilepsy may also induce epigenetic modifications and alter the structure of chromatin. As a consequence, changes in the expression of various factors involved in the pathology of epilepsy may positively or negatively affect the course of the disease. It should be noted that while AEDs are widely used in the treatment of epilepsy and other neurological disorders, many of their epigenetic consequences are still unknown...
November 16, 2018: Epilepsy Research
Tobin Ehrlich, Anny Reyes, Brianna M Paul, Vedang Uttarwar, Stephen Hartman, Kushagra Mathur, Yu-Hsuan A Chang, Manu Hegde, Jerry J Shih, Carrie R McDonald
OBJECTIVE: Individuals with temporal lobe epilepsy (TLE) often experience diminished quality of life (QoL). Although comorbid depression is one of the most recognized predictors of poor QoL in TLE, impairments in verbal memory (VM) and executive functioning (EF), have also been identified as risk factors, independent of other biological and psychosocial factors. In this study, we examine the contribution of depression, VM, and EF to QoL in 52 well-characterized medically-refractory TLE patients...
November 13, 2018: Epilepsy Research
Silvia Vincentiis, Juliana Alcantara, Patricia Rzezak, Daniel Kerr, Bernardo Dos Santos, Ruda Alessi, Helio van der Linden, Francisco Arruda, Tiffany Chaim-Avancini, Mauricio Serpa, Geraldo Busatto, Wagner Gattaz, Renata Demarque, Kette D Valente
BACKGROUND: There is evidence of an imbalance in the neuromodulatory system mediated by serotonin (5-HT) in patients with drug-resistant temporal lobe epilepsy (TLE). This study analyzed the monoamine oxidase A promoter variable number of tandem repeats (MAOA-uVNTR) polymorphism in patients with temporal lobe epilepsy with hippocampal sclerosis (TLE-HS). Therefore, we assessed the association between this genetic variant and seizure predisposition and severity in patients with TLE-HS...
November 12, 2018: Epilepsy Research
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