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Epilepsy Research

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https://www.readbyqxmd.com/read/29783181/autistic-traits-in-epilepsy-models-why-when-and-how
#1
REVIEW
Jana Velíšková, Jill L Silverman, Melissa Benson, Pierre-Pascal Lenck-Santini
Autism spectrum disorder (ASD) is a common comorbidity of epilepsy and seizures and/or epileptiform activity are observed in a significant proportion of ASD patients. Current research also implies that autistic traits can be observed to a various degree in mice and rats with seizures. This suggests that there are shared mechanisms in both ASD and epilepsy syndromes. Here, we first review the standard, validated methods used to assess autistic traits in animal models as well as their limitations with regards to epilepsy models...
May 18, 2018: Epilepsy Research
https://www.readbyqxmd.com/read/29778030/retrospective-genotype-phenotype-analysis-in-a-305-patient-cohort-referred-for-testing-of-a-targeted-epilepsy-panel
#2
Andrew N Hesse, Jennifer Bevilacqua, Kritika Shankar, Honey V Reddi
PURPOSE: Epilepsy is a diverse neurological condition with extreme genetic and phenotypic heterogeneity. The introduction of next-generation sequencing into the clinical laboratory has made it possible to investigate hundreds of associated genes simultaneously for a patient, even in the absence of a clearly defined syndrome. This has resulted in the detection of rare and novel mutations at a rate well beyond our ability to characterize their effects. This retrospective study reviews genotype data in the context of available phenotypic information on 305 patients spanning the epileptic spectrum to identify established and novel patterns of correlation...
May 16, 2018: Epilepsy Research
https://www.readbyqxmd.com/read/29778029/late-onset-childhood-neuronal-ceroid-lipofuscinosis-early-clinical-and-electroencephalographic-markers
#3
Lucas Beltrán, Gabriela Reyes Valenzuela, Mariana Loos, Rodrigo Vargas, Rafael Lizama, Pablo Spinsanti, Roberto Caraballo
PURPOSE: The objective of the study was to describe the initial clinical and electroencephalographic findings in children with late-infantile neuronal ceroid lipofuscinosis (LINCL). METHOD: The clinical charts of 35 patients seen between 1990 and 2016 were reviewed. The patients were divided into two groups: Group 1 (G1) consisting of 12 patients with NCL type 2 (CLN2) disease confirmed by enzymatic activity in dried blood spots on filter paper and/or genetic studies, and Group 2 (G2) consisting of 23 patients with a diagnosis of LINCL based on pathology studies by muscle biopsy...
May 15, 2018: Epilepsy Research
https://www.readbyqxmd.com/read/29751354/evaluation-of-knowledge-about-epilepsy-and-attitudes-towards-patients-with-epilepsy-among-university-students-in-upper-egypt
#4
Mohamed N Thabit, Mohamed A Sayed, Magda M Ali
PURPOSE: Epilepsy is a major public health problem worldwide. There are many misconceptions about people's knowledge and attitudes about epilepsy, which influence people's behavior towards patients with epilepsy. METHODS: We conducted a cross-sectional study in Sohag University, a public Egyptian University, in Upper Egypt. We used an Arabic language designed questionnaire to assess people's knowledge about epilepsy and their attitudes towards patients with epilepsy...
May 5, 2018: Epilepsy Research
https://www.readbyqxmd.com/read/29751355/targeting-of-microrna-21-5p-protects-against-seizure-damage-in-a-kainic-acid-induced-status-epilepticus-model-via-pten-mtor
#5
Chongyang Tang, Yunhe Gu, Haiyang Wang, Hongmei Wu, Yu Wang, Yao Meng, Zhibin Han, Yifei Gu, Wei Ma, Zhenfeng Jiang, Yuanyuan Song, Meng Na, Dunyue Lu, Zhiguo Lin
OBJECTIVE: Studies have shown that microRNAs play a role in the development of epilepsy by regulating downstream target messenger (m)RNA. The present study aims to determine the changes associated with microRNA-21-5p (miR-21-5p) during epileptogenesis in a kainic acid rat model, and to assess whether the PTEN-mTOR pathway is a target of miR-21-5p. METHOD: Reverse transcription polymerase chain reaction (RT-PCR) was used to examine the quantitative expressions of miR-21-5p and PTEN, and Western blotting was used to test the activity of mTOR in the acute, latent, and chronic stages of epileptogenesis...
May 4, 2018: Epilepsy Research
https://www.readbyqxmd.com/read/29751353/zonisamide-serum-concentrations-during-pregnancy
#6
Arne Reimers, Grethe Helde, Noémi Becser Andersen, Dag Aurlien, Elisabeth Surlien Navjord, Kathrine Haggag, Jakob Christensen, Kari Mette Lillestølen, Karl Otto Nakken, Eylert Brodtkorb
PURPOSE: To investigate the change in zonisamide (ZNS) serum concentration and its consequences in pregnant women with epilepsy. METHODS: Six hospitals in Norway and Denmark screened their records for women who had been using ZNS during pregnancy. Absolute serum concentrations as well as concentration/dose (CD)-ratios were compared to non-pregnant values. Descriptive data on seizure control and obstetrical data were also collected. RESULTS: 144 serum concentrations from 23 pregnancies in 15 individual women with epilepsy were included (six on monotherapy)...
May 4, 2018: Epilepsy Research
https://www.readbyqxmd.com/read/29775849/development-and-validation-of-the-chinese-version-of-the-adult-epilepsy-self-management-scale-c-esms-in-western-china
#7
Xiaoqiang Xiao, Yang Si, Qianning Mo, Yao Liu, Cong Li, Jialing Zhao, Shuai Ma, Lili Si, Zhijie Xi, Lang Chen, Dongmei Wu, Qin He, Meiling Hu, Chenqi Zhang, Hongbin Sun
PURPOSE: To develop and validate the Epilepsy Self-Management Scale (ESMS) for Chinese persons with epilepsy (PWE). METHODS: On the basis of ESMS, the standard translation procedure was used to set up the Chinese version of the ESMS (C-ESMS). A consecutive cohort of PWE admitted in Sichuan Provincial People's Hospital were recruited randomly from May 2017 to December 2017 and required to complete the C-ESMS. Project analysis was employed to test the homogeneity of each dimension...
May 2, 2018: Epilepsy Research
https://www.readbyqxmd.com/read/29727818/efficacy-and-safety-of-ketogenic-diet-for-treatment-of-pediatric-convulsive-refractory-status-epilepticus
#8
Ravindra Arya, Katrina Peariso, Marina Gaínza-Lein, Jessica Harvey, Ann Bergin, J Nicholas Brenton, Brian T Burrows, Tracy Glauser, Howard P Goodkin, Yi-Chen Lai, Mohamad A Mikati, Iván Sánchez Fernández, Dmitry Tchapyjnikov, Angus A Wilfong, Korwyn Williams, Tobias Loddenkemper
PURPOSE: To describe the efficacy and safety of ketogenic diet (KD) for convulsive refractory status epilepticus (RSE). METHODS: RSE patients treated with KD at the 6/11 participating institutions of the pediatric Status Epilepticus Research Group from January-2011 to December-2016 were included. Patients receiving KD prior to the index RSE episode were excluded. RSE was defined as failure of ≥2 anti-seizure medications, including at least one non-benzodiazepine drug...
April 27, 2018: Epilepsy Research
https://www.readbyqxmd.com/read/29723773/different-ketogenesis-strategies-lead-to-disparate-seizure-outcomes
#9
Alison Dolce, Polan Santos, Weiran Chen, Ahmet Hoke, Adam L Hartman
BACKGROUND: Despite the introduction of new medicines to treat epilepsy over the last 50 years, the number of patients with poorly-controlled seizures remains unchanged. Metabolism-based therapies are an underutilized treatment option for this population. We hypothesized that two different means of systemic ketosis, the ketogenic diet and intermittent fasting, would differ in their acute seizure test profiles and mitochondrial respiration. METHODS: Male NIH Swiss mice (aged 3-4 weeks) were fed for 12-13 days using one of four diet regimens: ketogenic diet (KD), control diet matched to KD for protein content and micronutrients (CD), or CD with intermittent fasting (24 h feed/24 h fast) (CD-IF), tested post-feed or post-fast...
April 27, 2018: Epilepsy Research
https://www.readbyqxmd.com/read/29729534/the-surgical-outcome-of-patients-with-bilateral-temporal-lobe-epilepsy
#10
Xiaoxia Zhou, Tao Yu, Guojun Zhang, Duanyu Ni, Liang Qiao, Xueyuan Wang, Cuiping Xu, Chang Liu, Yuping Wang, Yongjie Li
OBJECTIVES: The purpose of this study is to explore the surgical outcome of unilateral anterior temporal lobectomy (ATL) for patients with bilateral temporal lobe epilepsy (BTLE). METHODS: We retrospectively reviewed the data of patients who were diagnosed with BTLE by scalp electroencephalogram (EEG) and underwent ATL from 2001 to 2015. In addition, 80 patients were randomly selected as a control group. RESULTS: One hundred seventeen patients were included in this study and were divided into four groups by intracranial recordings as follows: 78 patients with unilateral seizure onset (Group 1), 13 patients with lateralizable dominant seizure onset (Group 2), 14 patients with lateralizable neuroimaging abnormalities (Group 3), and 12 patients without lateralizable dominant seizure onset or neuroimaging abnormalities (Group 4)...
April 26, 2018: Epilepsy Research
https://www.readbyqxmd.com/read/29729532/how-do-we-diagnose-and-treat-epilepsy-with-myoclonic-atonic-seizures-doose-syndrome-results-of-the-pediatric-epilepsy-research-consortium-survey
#11
Katherine Nickels, Ronald Thibert, Stephanie Rau, Scott Demarest, Elaine Wirrell, Eric H Kossoff, Charuta Joshi, Srishti Nangia, Renee Shellhaas
OBJECTIVE: To obtain and assess opinions on EMAS diagnostic criteria, recommended investigations, and therapeutic options, from a large group of physicians who care for children with EMAS. METHODS: The EMAS focus group of PERC created a survey to assess the opinions of pediatric neurologists who care for children with EMAS regarding diagnosis and treatment of this condition, which was sent to members of PERC, AES, and CNS. A Likert scale was used to assess the respondents' opinions on the importance of diagnostic and exclusion criteria (five point scale), investigations (four point scale), and treatment (six point scale) of EMAS...
April 25, 2018: Epilepsy Research
https://www.readbyqxmd.com/read/29729533/predictive-factors-of-higher-drug-load-for-seizure-freedom-in-idiopathic-generalized-epilepsy-comparison-between-juvenile-myoclonic-epilepsy-and-other-types
#12
Yu Kitazawa, Kazutaka Jin, Yosuke Kakisaka, Mayu Fujikawa, Fumiaki Tanaka, Nobukazu Nakasato
PURPOSE: Predictive factors of higher drug load for seizure freedom were investigated in idiopathic generalized epilepsy (IGE), focusing on the difference between juvenile myoclonic epilepsy (JME) and other types of IGE (non-JME IGE). METHODS: Twelve patients with JME and 12 patients with non-JME IGE, who achieved seizure freedom for 1 year or longer with appropriate antiepileptic drugs (AEDs) after video electroencephalography monitoring, were reviewed retrospectively...
April 23, 2018: Epilepsy Research
https://www.readbyqxmd.com/read/29691120/neuroprotective-effect-of-nrf2-activator-dimethyl-fumarate-on-the-hippocampal-neurons-in-chemical-kindling-model-in-rat
#13
Neha Singh, Sheekha Vijayanti, Lekha Saha, Alka Bhatia, Dibyajyoti Banerjee, Amitava Chakrabarti
BACKGROUND: Nuclear factor erythroid-2 related factor 2 (Nrf2) is a transcription factor, which activates the anti-oxidative stress response pathway. In epilepsy, oxidative stress is one of the key factors in the progression of the disease. So, the neuroprotective role of dimethyl fumarate (DMF), a Nrf2 pathway activator was explored in pentylenetetrazole (PTZ) induced kindling model of epilepsy in rats. METHODS: Male Wistar rats were subjected to different doses of DMF (15, 30, 60 mg/kg) to evaluate the effect on the PTZ induced kindling in rats...
April 21, 2018: Epilepsy Research
https://www.readbyqxmd.com/read/29705654/the-seizure-precipitating-effect-of-alcohol-a-prospective-observational-cross-over-study
#14
Christian Samsonsen, Harald Myklebust, Tåle Strindler, Geir Bråthen, Grethe Helde, Eylert Brodtkorb
PURPOSE: The aim of this study was to investigate the association between alcohol use and seizures in acutely hospitalized patients. We wished to study the extent of the problem as well as the clinical characteristics of people with various forms of alcohol-related seizures, including their drinking pattern. METHOD: After admission, a semi-structured interview took place with 134 consecutive patients (epilepsy 92, single seizures 42). Alcohol use was assessed by the Alcohol Use Disorders Identification Test (AUDIT) and by the number of alcohol units consumed during 6 days prior to the seizure...
April 13, 2018: Epilepsy Research
https://www.readbyqxmd.com/read/29656982/erratum-to-whole-brain-neuronal-abnormalities-in-focal-epilepsy-quantified-with-proton-mr-spectroscopy-epilepsy-res-139-2018-85-91
#15
Ivan I Kirov, Ruben Kuzniecky, Hoby P Hetherington, Brian J Soher, Matthew S Davitz, James S Babb, Heath R Pardoe, Jullie W Pan, Oded Gonen
No abstract text is available yet for this article.
April 13, 2018: Epilepsy Research
https://www.readbyqxmd.com/read/29669310/predictive-indicators-for-the-development-of-epilepsy-after-acute-encephalopathy-with-biphasic-seizures-and-late-reduced-diffusion
#16
Yuko Ichimiya, Noriyuki Kaku, Masafumi Sanefuji, Michiko Torio, Soichi Mizuguchi, Yoshitomo Motomura, Mamoru Muraoka, Sooyoung Lee, Haruhisa Baba, Yuri Sonoda, Yoshito Ishizaki, Momoko Sasazuki, Yasunari Sakai, Yoshihiko Maehara, Shouichi Ohga
Acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) is a newly defined clinicoradiologic syndrome characterized by biphasic seizures and altered consciousness followed by restricted diffusion in the white matter on magnetic resonance imaging in acute phase. Intractable epilepsy commonly occurs as the late complication. This study aimed to search predisposing factors to the development of epilepsy after AESD. Consecutively treated 22 patients with AESD in our institution from 2006 to 2016 were grouped into those with post-encephalopathic epilepsy (PEE, n = 10) or without PEE (n = 12)...
April 11, 2018: Epilepsy Research
https://www.readbyqxmd.com/read/29660559/potassium-dynamics-and-seizures-why-is-potassium-ictogenic
#17
REVIEW
Marco de Curtis, Laura Uva, Vadym Gnatkovsky, Laura Librizzi
Potassium channels dysfunction and altered genes encoding for molecules involved in potassium homeostasis have been associated with human epilepsy. These observations are in agreement with a control role of extracellular potassium on neuronal excitability and seizure generation. Epileptiform activity, in turn, regulates potassium homeostasis through mechanisms that are still not well established. We review here how potassium-associated processes are regulated in the brain and examine the mechanisms that support the role of potassium in triggering epileptiform activities...
April 10, 2018: Epilepsy Research
https://www.readbyqxmd.com/read/29665500/aromatase-inhibition-by-letrozole-attenuates-kainic-acid-induced-seizures-but-not-neurotoxicity-in-mice
#18
Ramsha Iqbal, Gaurav K Jain, Fouzia Siraj, Divya Vohora
Evidence shows neurosteroids play a key role in regulating epileptogenesis. Neurosteroids such as testosterone modulate seizure susceptibility through its transformation to metabolites which show proconvulsant and anticonvulsant effects, respectively. Reduction of testosterone by aromatase generates proconvulsant 17-β estradiol. Alternatively, testosterone is metabolized into 5α-dihydrotestosterone (5α-DHT) by 5α-reductase, which is then reduced by 3α-hydroxysteroid oxidoreductase enzyme (3α-HSOR) to form anticonvulsant metabolite 3α-androstanediol (3α-Diol), a potent GABAA receptor modulating neurosteroid...
April 9, 2018: Epilepsy Research
https://www.readbyqxmd.com/read/29655171/alterations-of-network-synchrony-after-epileptic-seizures-an-analysis-of-post-ictal-intracranial-recordings-in-pediatric-epilepsy-patients
#19
Samuel B Tomlinson, Ankit N Khambhati, Camilo Bermudez, Rebecca M Kamens, Gregory G Heuer, Brenda E Porter, Eric D Marsh
OBJECTIVE: Post-ictal EEG alterations have been identified in studies of intracranial recordings, but the clinical significance of post-ictal EEG activity is undetermined. The purpose of this study was to examine the relationship between peri-ictal EEG activity, surgical outcome, and extent of seizure propagation in a sample of pediatric epilepsy patients. METHODS: Intracranial EEG recordings were obtained from 19 patients (mean age = 11.4 years, range = 3-20 years) with 57 seizures used for analysis (mean = 3...
April 5, 2018: Epilepsy Research
https://www.readbyqxmd.com/read/29631130/potential-delays-in-referral-and-assessment-for-epilepsy-surgery-in-children-with-drug-resistant-early-onset-epilepsy
#20
Laura Prideaux, Sarah Barton, Wirginia Maixner, A Simon Harvey
OBJECTIVE: To study potential delays in epilepsy surgery in children with drug-resistant epilepsy (DRE) of early-onset. METHODS: Medical records were reviewed from 87 children with DRE and seizure onset before age 3 years who underwent epilepsy surgery between 2006 and 2015. Information was obtained about each child's epilepsy, treatment and specific time points in management. Time intervals along diagnostic, investigative, treatment and referral pathways were calculated...
April 3, 2018: Epilepsy Research
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