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Epilepsy Research

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https://www.readbyqxmd.com/read/29156327/asiatic-acid-and-maslinic-acid-attenuated-kainic-acid-induced-seizure-through-decreasing-hippocampal-inflammatory-and-oxidative-stress
#1
Zhi-Hong Wang, Mei-Chin Mong, Ya-Chen Yang, Mei-Chin Yin
Seizure is a neurological disorder including hippocampal oxidative and inflammatory stress, and glutamate toxicity. Thus, any agent(s) that mitigate(s) these events in hippocampus might attenuate seizure severity. The effects of asiatic acid (AA) or maslinic acid (MA) pre-administration at 20 or 40mg/kg body weight/day upon inflammatory, oxidative and apoptotic injury in hippocampus of kainic acid (KA)-treated mice were examined. KA induced seizure-like behavioral patterns, which was attenuated by AA or MA pre-administration...
November 17, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/29126018/the-epidemiological-and-clinical-characteristics-study-on-epilepsy-in-8-ethnic-groups-of-china
#2
ZhiPeng Yu, Kai Dong, Hong Chang, XiaoQin Huang, Yi Ren, ChunQiu Fan, QingFeng Ma, HaiQing Song, Qian Zhang, Jing Zhang, LiYuan Huang
To survey the epidemiological characteristics and clinical features on epilepsy in eight ethnic groups in Yunnan province of China. METHODES: The investigation was based on the WHO questionnaire and ICBERG screening questionnaire. This study was performed through random cluster sampling and door-to-door survey. RESULTS: A total of 76,302 individuals from eight ethnic groups were surveyed. The crude prevalence of epilepsy ranged from 1.2/1000 to 6.5/1000 in the eight ethnic groups, and the age-adjusted prevalence of epilepsy was from 2...
November 7, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/29144992/intracerebroventricular-injection-of-mir-146a-relieves-seizures-in-an-immature-rat-model-of-lithium-pilocarpine-induced-status-epilepticus
#3
Xiaole Wang, Fei Yin, Linhong Li, Huimin Kong, Baiyang You, Weixi Zhang, Shuyuan Chen, Jing Peng
OBJECTIVE: Status epilepticus (SE) is a common, life-threatening neurological emergency that confers a high degree of morbidity and mortality. Increasing evidence indicates that neuroinflammation plays a critical role in the pathogenesis of SE. MicroRNA-146a (miR-146a) has been reported to be an important posttranscriptional inflammation-associated microRNA. The aim of this study was to investigate the effect of miR-146a in SE and the mechanism by which it operates. METHODS: To study the effect of miR-146a in SE, we chose intracerebroventricular injection for rat at 21-28days old, and made a lithium-pilocarpine-induced SE rat model...
November 4, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/29127848/influence-of-titration-schedule-and-maintenance-dose-on-the-tolerability-of-adjunctive-eslicarbazepine-acetate-an-integrated-analysis-of-three-randomized-placebo-controlled-trials
#4
Gregory Krauss, Victor Biton, Jay H Harvey, Christian Elger, Eugen Trinka, Patrício Soares da Silva, Helena Gama, Hailong Cheng, Todd Grinnell, David Blum
OBJECTIVE: To examine the influence of titration schedule and maintenance dose on the incidence and type of treatment-emergent adverse events (TEAEs) associated with adjunctive eslicarbazepine acetate (ESL). METHODS: Data from three randomized, double-blind, placebo-controlled trials were analyzed. Patients with refractory partial-onset seizures were randomized to maintenance doses of ESL 400, 800, or 1200mg QD (dosing was initiated at 400 or 800mg QD) or placebo...
November 4, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/29096135/use-of-antiepileptic-drugs-and-risk-of-falls-in-old-age-a-systematic-review
#5
REVIEW
Ylva Haasum, Kristina Johnell
OBJECTIVE: The aim of this study is to systematically review the scientific literature to investigate if use of antiepileptic drugs (AEDs) is associated with falls and/or recurrent falls in old age. METHOD: We searched the literature for relevant articles in PubMed and Embase published up until 3rd December 2015. Studies on people aged 60 years and over with an observational design assessing the risk of fall in people exposed to AEDs compared to people not exposed to AED were included...
October 30, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/29096134/modification-of-the-natural-progression-of-epileptogenesis-by-means-of-biperiden-in-the-pilocarpine-model-of-epilepsy
#6
Simone Bittencourt, Enéas Ferrazoli, Maria Fernanda Valente, Simone Romariz, Nilma R L L Janisset, Carlos Eduardo Macedo, Bruno de Brito Antonio, Vanessa Barros, Mayara Mundim, Marimélia Porcionatto, Mayra Consuelo Aarão, Maísa Ferreira Miranda, Antônio Márcio Rodrigues, Antônio-Carlos Guimarães de Almeida, Beatriz M Longo, Luiz E Mello
Brain injuries are often associated with the later development of epilepsy. Evidence suggests that morphological and functional changes occur in the remaining neural tissue during a silent (or latent) period in which no seizures are expressed. It is believed that this silent (reorganization) period may provide a therapeutic window for modifying the natural history of disease progression. Here we provide evidence that biperiden, a muscarinic anticholinergic agent, is able to alter disease progression in an animal model of epilepsy...
October 29, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/29096133/eslicarbazepine-acetate-and-carotid-intima-media-thickness-in-epileptic-patients
#7
Pedro Jesús Serrano-Castro, Javier Fernández-Pérez, Francisco Javier López-González, Manuel Toledo-Argany, José Carlos Estévez-María, Antonio Arjona-Padillo, Vicente Bertol-Alegre, José Angel Mauri-Llerda, Diego Tortosa-Conesa, Jesús Ruiz-Giménez, Rosa Querol-Pascual, Alberto García-Martínez, José Manuel Molto-Jorda, Manuel Payán-Ortiz, José Francisco Maestre-Moreno, José Galván-Espinosa
OBJECTIVE: Evaluate if eslicarbazepine acetate (ESL) in combination with other non-inducer antiepileptic drugs (AEDs) in the treatment of epilepsy may represent a positive impact in the cardiovascular risk profile. METHODS: multicentre, retrospective, observational, non-interventional, real-life study comparing patients treated with cytochrome P450 (CYP) inducer vs. ESL plus non-inducer AEDs. Primary endpoint: Carotid intima-media thickness (CIMT) measured following the Manheim Consensus criteria...
October 29, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/29144993/evaluate-the-effects-of-antiepileptic-drugs-on-reproductive-endocrine-system-in-newly-diagnosed-female-epileptic-patients-receiving-either-valproate-or-lamotrigine-monotherapy-a-prospective-study
#8
Harpreet Singh Sidhu, R Srinivasa, Akshay Sadhotra
OBJECTIVE: To investigate the development of reproductive endocrine changes in Indian women with epilepsy initiating on either Valproate (VPA) or Lamotrigine (LTG) monotherapy. METHODS: Reproductive hormonal profiles, hirsutism, ovarian morphology by ultrasonography and menstrual cycle data in newly diagnosed women with epilepsy taking VPA (n=34) or LTG (n=32) monotherapy were compared. None of the women were receiving hormonal contraception. Patients gave details of seizure type and frequency, medical and drug history...
October 28, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/29128679/early-onset-epileptic-encephalopathy-with-de-novo-scn8a-mutation
#9
Yangyang Xiao, Jie Xiong, Ding'an Mao, Lingjuan Liu, Jian Li, Xingfang Li, Haiyan Luo, Liqun Liu
Early-onset epileptic encephalopathies (EOEEs) are clinically and genetically heterogeneous disorders characterized by intractable seizures and unremitting interictal paroxysmal epileptiform activity. Consequently, these syndromes impair neurodevelopment during the first year of life. Currently, the etiology of these disorders is largely unknown. In this study, Childhood-Onset Epilepsy Gene Panel Testing (containing 511 epilepsy-related genes) was performed in a parent-offspring trio. In this family, the son had refractory seizures, intellectual disability, and motor abnormalities, and he was diagnosed with EOEE...
October 28, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/29100172/earlier-seizure-onset-and-longer-epilepsy-duration-correlate-with-the-degree-of-temporal-hypometabolism-in-patients-with-mesial-temporal-lobe-sclerosis
#10
Carlos Leiva-Salinas, Mark Quigg, W Jeffrey Elias, James T Patrie, Lucia Flors, Nathan B Fountain, Patrice K Rehm
OBJECTIVE: To study the relationship of glucose metabolism and volume of the temporal lobes with age at epilepsy onset, epilepsy duration, and seizure frequency in patients with mesial temporal sclerosis (MTS). METHODS: We evaluated the pre-surgical (18)F-fluoro-deoxyglucose (FDG) positron emission tomography (PET) and magnetic resonance imaging (MRI) of 18 patients with epilepsy and MRI findings of MTS, who were seizure-free for at least 2-years after temporal lobectomy...
October 28, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/29111296/a-neurosurgeon-s-view-laser-interstitial-thermal-therapy-of-mesial-temporal-lobe-structures
#11
Yarema B Bezchlibnyk, Jon T Willie, Robert E Gross
Stereotactic laser ablation of mesial temporal structures is a promising new surgical intervention for patients with mesial temporal lobe epilepsy (MTLE). Since this procedure was first used to treat MTLE in 2010, the literature contains reports of 37 patients that underwent MR-guided stereotactic laser amygdalohippocampotomy (SLAH) using Laser Interstitial Thermal Therapy (LITT) with at least 1year of follow-up. This early body of data suggests that SLAH is a safe and effective treatment for MTLE in properly selected patients...
October 27, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/29096132/atomic-force-microscopy-investigations-of-fibronectin-and-%C3%AE-5%C3%AE-1-integrin-signaling-in-neuroplasticity-and-seizure-susceptibility-in-experimental-epilepsy
#12
Xin Wu, Mariappan Muthuchamy, Doodipala Samba Reddy
Extracellular matrix protein-integrin interaction on neurons plays an important role in the development of neuroplasticity in the brain. However, the role of fibronectin-integrin signaling in epilepsy is elusive. Here, we examined the functional role of fibronectin-integrin signaling by utilizing a combination approach involving atomic force microscopy (AFM), immunocytochemistry, and pharmacology in epileptic mouse dentate gyrus granule cells (DGGCs). There was marked increase in the fibronectin receptor α5β1-integrin staining intensity in DGGCs in epileptic mice...
October 24, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/29054051/the-incidence-and-risk-factors-of-epilepsy-in-children-born-preterm-a-nationwide-register-study
#13
Mikko Hirvonen, Riitta Ojala, Päivi Korhonen, Paula Haataja, Kai Eriksson, Mika Gissler, Tiina Luukkaala, Outi Tammela
OBJECTIVES: The aim was to compare the incidence of epilepsy between very preterm (VP) (<32(+0) weeks), moderately preterm (MP) (32(+0)-33(+6) weeks), late preterm (LP) (34(+0)-36(+6) weeks) and term infants (≥37 weeks) and to establish and compare risk factors of epilepsy in these groups. METHODS: The national register study included all live born infants in Finland in 1991-2008. Excluding infants with missing gestational age, a total of 1,033,349 infants were included in the analysis and they were analyzed in four subgroups (VP, MP, LP and term) and three time periods (1991-1995, 1996-2001 and 2002-2008)...
October 14, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/29080472/the-expression-of-g-protein-coupled-receptor-kinase-5-and-its-interaction-with-dendritic-marker-microtubule-associated-protein-2-after-status-epilepticus
#14
Xiangchang Zeng, Siyu Chen, Qing Gao, Wenjing Zong, Dejian Jiang, Guirong Zeng, Luping Zhou, Lulu Chen, Wei Luo, Jian Xiao, Bo Xiao, Dongsheng Ouyang, Kai Hu
OBJECTIVE: Acute seizures induced dendritic formation and synaptogenesis promotes aberrant circuitry development and further aggravates underlying conditions towards chronic epilepsy. The G protein-coupled receptor kinase-5 (GRK5) served as a key modulator in neurogenesis and the establishment of functional neuronal circuitry. This included dendritic development, as its dysfunction could cause different central nervous system disorders, including Alzheimer's disease. However, the involvement of GRK5 in the progression of epilepsy remains unclear...
October 13, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/29059589/high-frequency-burst-vagal-nerve-simulation-therapy-in-a-natural-primate-model-of-genetic-generalized-epilepsy
#15
C Á Szabó, F S Salinas, A M Papanastassiou, J Begnaud, M Ravan, K S Eggleston, R Shade, C Lutz, M De La Garza
PURPOSE: Since the approval of Vagal Nerve Stimulation (VNS) Therapy for medically refractory focal epilepsies in 1997, it has been also reported to be effective for a wide range of generalized seizures types and epilepsy syndromes. Instead of conventional VNS Therapy delivered at 20-30Hz signal frequencies, this study evaluates efficacy and tolerability of high-frequency burst VNS in a natural animal model for genetic generalized epilepsy (GGE), the epileptic baboon. METHODS: Two female baboons (B1 P...
October 12, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/29040828/neuropsychological-functioning-and-brain-energetics-of-drug-resistant-mesial-temporal-lobe-epilepsy-patients
#16
Camila Moreira Osório, Alexandra Latini, Rodrigo Bainy Leal, Maria Emília Rodrigues de Oliveira Thais, Helena Dresch Vascouto, Aline Pertile Remor, Mark William Lopes, Marcelo Neves Linhares, Juliana Ben, Roberta de Paula Martins, Rui Daniel Prediger, Alexandre Ademar Hoeller, Hans Joachim Markowitsch, Peter Wolf, Kátia Lin, Roger Walz
Interictal hypometabolism is commonly measured by 18-fluoro-deoxyglucose Positron Emission Tomography (FDG-PET) in the temporal lobe of patients with mesial temporal lobe epilepsy (MTLE-HS). Left temporal lobe interictal FDG-PET hypometabolism has been associated with verbal memory impairment, while right temporal lobe FDG-PET hypometabolism is associated with nonverbal memory impairment. The biochemical mechanisms involved in these findings remain unknown. In comparison to healthy controls (n=21), surgically treated patients with MTLE-HS (n=32, left side=17) had significant lower scores in the Rey Auditory Verbal Learning Test (RAVLT retention and delayed), Logical Memory II (LMII), Boston Naming test (BNT), Letter Fluency and Category Fluency...
October 12, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/29073578/long-term-retention-rates-for-antiepileptic-drugs-a-review-of-long-term-extension-studies-and-comparison-with-brivaracetam
#17
REVIEW
Manuel Toledo, Rebecca Beale, Jennifer S Evans, Sara Steeves, Sami Elmoufti, Rebecca Townsend, John Whitesides, Simon Borghs
Antiepileptic drug (AED) retention rates are frequently reported in the literature and used to inform clinical decision-making, but methodological differences in the determination of retention rates make comparisons between trials difficult. Open-label extension (OLE) studies of AEDs in patients with focal epilepsy were identified from the literature. Retention calculation methods were reviewed, and published AED retention rates qualitatively compared with corresponding data for brivaracetam (BRV), a synaptic vesicle protein 2A ligand...
October 10, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/29055263/sub-cortical-brain-morphometry-and-its-relationship-with-cognition-in-rolandic-epilepsy
#18
Mahsa Shakeri, Alexandre N Datta, Domitille Malfait, Nadine Oser, Laurent Létourneau-Guillon, Philippe Major, Myriam Srour, Alan Tucholka, Samuel Kadoury, Sarah Lippé
PURPOSE: Rolandic epilepsy (RE), also called benign epilepsy with centrotemporal spikes (BECTS) is the most common childhood epilepsy syndrome. RE is associated with cognitive difficulties, which can affect children's quality of life. The underlying causes of these cognitive impairments are unclear. The objective of this prospective study is to investigate sub-cortical morphological alterations in RE children with left, right, or bilateral hemispheric focus and its association with cognition...
October 7, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/29031865/a-neuropsychologist-s-view-outcome-after-rf-ablation-for-mtle
#19
REVIEW
Lenka Krámská, Jiří Lukavský, Zdeněk Vojtěch
Concern about postoperative worsening of cognitive functions after temporal lobe epilepsy surgery is an important issue. In this article we review our data on neuropsychological outcome after radiofrequency (RF) ablation of amygdalohippocampal complex (AHC). On a group level we found initial improvement in intelligence domains and unchanged memory scores one year after the surgery. During longitudinal follow-up, we found improvement in both intellectual and memory domains. This improvement was most pronounced up to two years after surgery...
October 6, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/29028517/effect-of-carbamazepine-and-oxcarbazepine-on-serum-neuron-specific-enolase-in-focal-seizures-a-randomized-controlled-trial
#20
Rituparna Maiti, Biswa Ranjan Mishra, Soham Sanyal, Debadatta Mohapatra, Sansita Parida, Archana Mishra
Neuron-specific enolase (NSE) is the most investigated biomarker in the context of epilepsy and brain damage. The present study was conducted to investigate the change in serum NSE in patients with focal seizure and the effect of carbamazepine and oxcarbazepine on serum NSE. The present study is a randomized, open-label, parallel design clinical trial (ClinicalTrials.gov Identifier: NCT02705768) conducted on 60 patients of focal seizure. After recruitment, detailed history, clinical evaluations including Chalfont-National Hospital seizure severity scale (NHS3), Quality of Life in Epilepsy Inventory (QOLIE-31) and serum NSE estimation were done at baseline...
October 6, 2017: Epilepsy Research
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