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Epilepsy Research

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https://www.readbyqxmd.com/read/28719803/elevated-sterol-regulatory-elementary-binding-protein-1-and-glua2-levels-in-the-hippocampal-nuclear-fraction-of-genetic-absence-epilepsy-rats-from-strasbourg
#1
Sathiya Sekar, Entesar Omran, Venkat Gopalakrishnan, John G Howland, Terrance P Snutch, Changiz Taghibiglou
Studies in animal models and human tissues show that nuclear translocation of sterol regulatory element binding protein 1 (SREBP1) and glutamate A2 subunit (GluA2) of cell-surface AMPA receptor (AMPAR) trigger neuronal excitotoxicity-induced apoptosis in stroke. However, it is not known whether a similar type of underlying pathophysiology occurs in absence epilepsy. To explore this issue, we examined the levels of mature SREBP1, GluA2, glyceraldehyde 3-phosphate dehydrogenase (GAPDH), p53, and activated to total caspase 3 ratio in nuclear fractions (NF) of hippocampal homogenate from 8 to 10 week old male Genetic Absence Epilepsy Rats from Strasbourg (GAERS) and non-epileptic control (NEC) strains...
July 12, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/28716297/on-the-relative-merits-of-invasive-and-non-invasive-pre-surgical-brain-mapping-new-tools-in-ablative-epilepsy-surgery
#2
Andrew C Papanicolaou, Roozbeh Rezaie, Shalini Narayana, Asim F Choudhri, Abbas-Babajani-Feremi, Frederick A Boop, James W Wheless
Cortical Stimulation Mapping (CSM) and the Wada procedure have long been considered the gold standard for localizing motor and language-related cortical areas and for determining the language and memory-dominant hemisphere, respectively. In recent years, however, non-invasive methods such as magnetoencephalography (MEG), functional magnetic resonance imaging (fMRI), and transcranial magnetic stimulation (TMS) have emerged as promising alternatives to the aforementioned procedures, particularly in cases where the invasive localization of eloquent cortex has proven to be challenging...
July 3, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/28705474/rf-ablation-in-periventricular-heterotopia-related-epilepsy
#3
Massimo Cossu, Laura Mirandola, Laura Tassi
Drug-resistant focal epilepsy is a common occurrence in patients with gray matter nodular heterotopia (NH), and surgical treatment is often considered in these cases. NH-related epileptogenicity is sustained by complex networks, which may involve the nodules and extralesional cortex in various combinations. Therefore, invasive EEG is usually required to identify the structures involved in seizure generation. It has been reported that surgery may be effective in cases with unilateral lesions, whereas bilateral cases are not optimal candidates for surgical success...
July 3, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/28697489/subjective-sleep-disturbance-in-chinese-adults-with-epilepsy-associations-with-affective-symptoms
#4
Yeru Shen, Mengmeng Zhang, Yu Wang, Lanlan Wang, Xiangjun Xu, Gairong Xiao, Jing Chen, Ting Zhang, Nong Zhou
BACKGROUND: As well as being a very common neurological disease worldwide, epilepsy significantly impairs patients' emotional, behavioral, and cognitive functioning. Sleep disturbances are the most frequent complaint in patients with epilepsy. The present study assesses the impact of a range of affective symptoms on subjective sleep quality and sleep disturbances in Chinese adults with epilepsy. METHODS: Adults with epilepsy who visited our epilepsy clinic from July 2015 to March 2016 were enrolled in our study...
July 1, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/28709079/breastfeeding-initiation-duration-and-exclusivity-in-mothers-with-epilepsy-from-south-west-china
#5
Nanya Hao, Han Jiang, Mengqian Wu, Tianying Pan, Bo Yan, Jie Liu, Jie Mu, Wenyu Liu, Jinmei Li, Terence J O'Brien, Zhibin Chen, Frank Vajda, Dong Zhou
PURPOSES: 1) To study the breastfeeding initiation, duration and exclusivity rates, and common reasons for early weaning in Chinese mothers with epilepsy (MWE); 2) To identify potential perinatal breastfeeding correlations with selected sociodemographic and clinical factors. METHODS: A semi-structured questionnaire was administered to 281 MWE attending hospitals in South-west China from February 2014 to July 2015. Data about breastfeeding behaviors, sociodemographic, obstetric, and epileptic variables were collected...
June 30, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/28692872/changes-in-the-content-of-fatty-acids-in-ca1-and-ca3-areas-of-the-hippocampus-of-krushinsky-molodkina-rats-after-single-and-fivefold-audiogenic-seizures
#6
Tatyana Savina, Alexander Aripovsky, Tatyana Kulagina
Audiogenic seizures (AS) are generalized seizures evoked by high frequency sounds. Since the hippocampus is involved in the generation and maintenance of seizures, the effect of AS on the composition and content of fatty acids in the CA1 and CA3 hippocampal areas of AS-susceptible Krushinsky-Molodkina (KM) rats on days 1, 3, and 14 after single and fivefold seizures were examined. The total content of all fatty acids in field СА1 was found to be lower compared with the control at all times of observation after both a single seizure or fivefold seizures...
June 24, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/28688333/toxoplasmosis-accelerates-acquisition-of-epilepsy-in-rats-undergoing-chemical-kindling
#7
Jalal Babaie, Mohammad Sayyah, Samira Choopani, Tara Asgari, Majid Golkar, Kourosh Gharagozli
Epilepsy is one of the most common neurologic disorders worldwide with no distinguishable cause in 60% of patients. One-third of the world population has been infected with Toxoplasma gondii. This intracellular parasite has high tropism for excitable cells including neurons. We assessed impact of acute and chronic T. gondii infection on epileptogenesis in pentylenetetrazole (PTZ) kindling model in male rats. T. gondii cysts were administered to rats by intraperitoneal (i.p.) injection. The presence of T. gondii cysts in the brain of rats was verified by hematoxylin-eosin staining...
June 24, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/28675819/anti-neuronal-autoantibodies-in-both-drug-responsive-and-resistant-focal-seizures-with-unknown-cause
#8
Gokcen Gozubatik-Celik, Cigdem Ozkara, Canan Ulusoy, Aysegul Gunduz, Sakir Delil, Naz Yeni, Erdem Tuzun
BACKGROUND: and Objective Autoimmunity is an emerging field of research in the etiology of different neurological disorders including epilepsy. We aimed to investigate the presence of neuronal autoantibodies in focal epilepsy with unknown cause and their clinical correlates in both drug-responsive and resistant patients. METHOD: Between 2009 and 2010 94 patients were prospectively enrolled, had their antibodies tested and clinically followed." An additional 50 age- and gender-matched controls were also tested for antibodies...
June 17, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/28654830/analysis-of-variations-of-correlation-dimension-and-nonlinear-interdependence-for-the-prediction-of-pediatric-myoclonic-seizures-a-preliminary-study
#9
Mohamad Amin Sharifi Kolarijani, Susan Amirsalari, Mohsen Reza Haidari
In this preliminary study, we evaluated the predictive ability of Correlation Dimension (CD) and Nonlinear Interdependence (NI) for seizures in pediatric myoclonic epilepsy patients. Scalp EEG recordings of eight diagnosed cases of myoclonic epilepsy were analyzed using Receiver Operating Curve (ROC) for discriminating the preictal period from interictal period. Furthermore, based on clinical seizure characteristics and EEG data, the spatiotemporal patterns of measures in clinically relevant areas of the brain were compared with other areas for each patient...
June 17, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/28644979/intraoperative-fast-ripples-independently-predict-postsurgical-epilepsy-outcome-comparison-with-other-electrocorticographic-phenomena
#10
Shaun A Hussain, Gary W Mathern, Phoebe Hung, Julius Weng, Raman Sankar, Joyce Y Wu
In the surgical management of epilepsy, the resection of cortex exhibiting interictal fast ripples (250-500Hz) on electrocorticography has been linked to postoperative seizure-freedom. Although fast ripples appear to accurately identify the epileptogenic zone-the minimum tissue that must be removed at surgery to achieve seizure-freedom-it has not been established that fast ripples are a superior biomarker in comparison with multimodal presurgical neuroimaging and other electrocorticography abnormalities. Hence, in the prediction of postoperative seizure-freedom, we compared the value of fast ripples with other intraoperative electocorticography abnormalities including focal slowing, paroxysmal fast activity, intermittent spike discharges, continuous epileptiform discharges, focal attenuation, and intraoperative seizures, as well as complete resection of the lesion defined by MRI and other neuroimaging...
June 16, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/28666153/electroencephalographic-findings-in-patients-with-circumscribed-thalamic-lesions
#11
Elene Tsoures, Jan Lewerenz, Elmar Pinkhardt, Albert C Ludolph, Susanne Fauser
INTRODUCTION: Thalamo-cortical networks have mainly been studied in the generation of idiopathic (genetic) epilepsies. The purpose of this study was to analyze EEG patterns and the occurrence of focal (symptomatic) epileptic seizures in patients with acquired circumscribed thalamic lesions. PATIENTS AND METHODS: Among 596 patients with thalamic lesions, we identified 47 patients in whom circumscribed thalamic lesions were detected by MRI and who underwent an EEG examination at the same stay at hospital...
June 15, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/28624183/the-neuroprotective-effect-of-perampanel-in-lithium-pilocarpine-rat-seizure-model
#12
Ting Wu, Katsutoshi Ido, Yoshihide Osada, Sadaharu Kotani, Akira Tamaoka, Takahisa Hanada
PURPOSE: Status epilepticus (SE) causes irreversible neurodegeneration if not terminated quickly. Perampanel (PER), a potent AMPA receptor antagonist, has previously been shown to terminate seizures in the lithium-pilocarpine SE model. In the present study, we assessed whether PER would also prevent neuronal damage in this model. METHODS: SE was induced in rats using lithium chloride and pilocarpine. Initiation of SE was defined as continuous seizures that exhibited as rearing accompanied by bilateral forelimb clonus (Racine score 4)...
June 14, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/28641219/comparison-of-brand-versus-generic-antiepileptic-drug-adverse-event-reporting-rates-in-the-u-s-food-and-drug-administration-adverse-event-reporting-system-faers
#13
Md Motiur Rahman, Yasser Alatawi, Ning Cheng, Jingjing Qian, Annya V Plotkina, Peggy L Peissig, Richard L Berg, David Page, Richard A Hansen
OBJECTIVE: Despite the cost saving role of generic anti-epileptic drugs (AEDs), debate exists as to whether generic substitution of branded AEDs may lead to therapeutic failure and increased toxicity. This study compared adverse event (AE) reporting rates for brand vs. authorized generic (AG) vs. generic AEDs. Since AGs are pharmaceutically identical to brand but perceived as generics, the generic vs. AG comparison minimized potential bias against generics. METHODS: Events reported to the U...
June 13, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/28667867/autophagy-related-protein-expression-was-associated-with-braf-v600e-mutation-in-epilepsy-associated-glioneuronal-tumors
#14
Chun-Hong Shen, Yin-Xi Zhang, Jin-Hong Xu, Qiong-Bin Zhu, Jun-Ming Zhu, Yi Guo, Yao Ding, Shuang Wang, Mei-Ping Ding
PURPOSE: The aim of this study was to explore the expression level of autophagy-related proteins in epileptic patients with glioneuronal tumors (GNTs) and evaluate the association with clinicopathological features. MATERIALS AND METHODS: We obtained the brain specimens from 33 patients with GNTs, including 22 gangliogliomas (GGs) and 11 dysembryoplastic neuroepithelial tumors (DNTs). The expression of two autophagy-related proteins (LC3B and Beclin-1) was evaluated by immunohistochemistry, and BRAF V600E mutation was examined by DNA sequencing...
June 12, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/28618377/ring-and-peg-electrodes-for-minimally-invasive-and-long-term-sub-scalp-eeg-recordings
#15
Y B Benovitski, A Lai, C C McGowan, O Burns, V Maxim, D A X Nayagam, R Millard, G D Rathbone, M A le Chevoir, R A Williams, D B Grayden, C N May, M Murphy, W J D'Souza, M J Cook, C E Williams
OBJECTIVE: Minimally-invasive approaches are needed for long-term reliable Electroencephalography (EEG) recordings to assist with epilepsy diagnosis, investigation and more naturalistic monitoring. This study compared three methods for long-term implantation of sub-scalp EEG electrodes. METHODS: Three types of electrodes (disk, ring, and peg) were fabricated from biocompatible materials and implanted under the scalp in five ambulatory ewes for 3months. Disk electrodes were inserted into sub-pericranial pockets...
June 12, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/28651086/age-at-first-febrile-seizure-correlates-with-perinatal-maternal-emotional-symptoms
#16
Fanny Thébault-Dagher, Catherine M Herba, Jean R Séguin, Gina Muckle, Sonia J Lupien, Lionel Carmant, Marie-Noëlle Simard, Gabriel D Shapiro, William D Fraser, Sarah Lippé
OBJECTIVE: Prenatal exposure to stress and fever are factors lowering seizure threshold in animal models. The fever effect on seizure threshold is well documented in human infants, however the associations between maternal perinatal stress and infants' susceptibility to seizures is unknown. This is the first study in humans to investigate longitudinally, whether in humans, the effect of maternal perinatal emotional symptoms such as stress, anxiety and depression that may trigger a biological stress response on age at first seizure occurrence...
June 10, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/28623837/abnormal-asymmetry-in-benign-epilepsy-with-unilateral-and-bilateral-centrotemporal-spikes-a-combined-fmri-and-dti-study
#17
Weifang Cao, Yaodan Zhang, Changyue Hou, Fei Yang, Jinnan Gong, Sisi Jiang, Yue Huang, Ruhui Xiao, Cheng Luo, Xiaoming Wang, Dezhong Yao
Benign epilepsy with centrotemporal spikes (BECTS) is the most common idiopathic focal childhood epilepsy associated with either unilateral or bilateral epileptic discharge. Asymmetry as an important characteristic of the human brain is beneficial for brain functions. However, little is known about on asymmetry of BECTS patients with different epileptic spikes pattern. In the present study, we investigated functional and structural asymmetries in unilateral spikes BECTS (U_BECTS) patients and bilateral spikes BECTS (B_BECTS) patients using resting state functional magnetic resonance images and diffusion tensor imaging...
June 8, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/28622538/current-psychiatric-disorders-in-patients-with-epilepsy-are-predicted-by-maltreatment-experiences-during-childhood
#18
Kirsten Labudda, Dominik Illies, Cornelia Herzig, Katharina Schröder, Christian G Bien, Frank Neuner
PURPOSE: Childhood maltreatment has been shown to be a risk factor for the development of psychiatric disorders. Although the prevalence of psychiatric disorders is high in epilepsy patients, it is unknown if childhood maltreatment experiences are elevated compared to the normal population and if early maltreatment is a risk factor for current psychiatric comorbidities in epilepsy patients. This is the main purpose of this study. METHODS: Structured interviews were used to assess current Axis I diagnoses in 120 epilepsy patients from a tertiary Epilepsy Center (34 TLE patients, 86 non-TLE patients)...
June 8, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/28709078/insomnia-in-people-with-epilepsy-a-review-of-insomnia-prevalence-risk-factors-and-associations-with-epilepsy-related-factors
#19
REVIEW
Philippe Joaquim Oliveira Menezes Macêdo, Pedro Sudbrack de Oliveira, Nancy Foldvary-Schaefer, Marleide da Mota Gomes
BACKGROUND: Insomnia is a common sleep complaint in the general population, and sleep loss may be a trigger for epileptic seizures. OBJECTIVES: To conduct a comprehensive review of the literature of insomnia symptoms and insomnia disorder, their prevalence and epilepsy-related risk factors in people with epilepsy (PWE). METHODS: A PUBMED search was performed for articles indexed to June 2016 involving human subjects, excluding papers in languages other than English, Spanish and Portuguese and case reports...
June 3, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/28618376/association-between-the-hla-b-alleles-and-carbamazepine-induced-sjs-ten-a-meta-analysis
#20
REVIEW
Qianyu Wang, Shusen Sun, Meng Xie, Kun Zhao, Xingang Li, Zhigang Zhao
PURPOSE: From our current understanding, the association between the human leukocyte antigen (HLA), HLA-B*1502, and carbamazepine(CBZ)-induced Stevens-Jonson syndrome and toxic epidermal necrolysis (SJS/TEN) in the Asian population is quite clear. However the relationship between other HLA-B alleles and CBZ-induced severe cutaneous adverse drug reactions (SCADRs) remains unclear. We aimed to identify other non-HLA-B*1502 alleles in patients with CBZ-induced SCADRs through a meta-analysis...
June 3, 2017: Epilepsy Research
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