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Human Psychopharmacology

Yoshiyuki Tsuruta, Kunihiro Iwamoto, Masahiro Banno, Naoko Kawano, Kunihiro Kohmura, Seiko Miyata, Hiroshige Fujishiro, Yukihiro Noda, Akiko Noda, Shuji Iritani, Norio Ozaki
OBJECTIVE: To assess the effects of hypnotics on prefrontal cortex activity in healthy subjects using near-infrared spectroscopy (NIRS) in a double-blind, placebo-controlled crossover trial. METHODS: Eighteen healthy males received acute doses of ramelteon (8 mg), triazolam (0.125 mg), or placebo in a predetermined randomization schedule, with a washout period of more than 1 week. All subjects performed a verbal fluency task during NIRS assessments at baseline and at 1 and 4 hr post-dose...
October 25, 2018: Human Psychopharmacology
Michael S Zastrozhin, Aleksandr S Sorokin, Tatyana V Agibalova, Elena A Grishina, Anastasiya Р Antonenko, Ilya N Rozochkin, Denis V Duzhev, Valentine Y Skryabin, Tatyana E Galaktionova, Ilya V Barna, Anna V Orlova, Albert D Aguzarov, Ludmila M Savchenko, Evgeny A Bryun, Dmitry A Sychev
INTRODUCTION: Although pharmacogenetic tests provide the information on a genotype and the predicted phenotype, these tests themselves do not provide the interpretation of data for a physician. There are currently approximately two dozen pharmacogenomic clinical decision support systems used in psychiatry. Implementation of clinical decision support systems capable of forming recommendations on drug and dose selection according to the results of pharmacogenetic testing is an urgent task...
October 25, 2018: Human Psychopharmacology
Patrick C Dolder, Elizabeth B de Sousa Fernandes Perna, Natasha L Mason, Nadia R P W Hutten, Stefan W Toennes, Eef L Theunissen, Johannes G Ramaekers, Kim P C Kuypers
OBJECTIVES: 4-Fluoroamphetamine (4-FA) is a novel psychoactive substance with a pharmacological profile and reported subjective effects (e.g., empathy) intermediate between 3,4-methylenedioxymethamphetamine (MDMA) and amphetamine. Studies have shown that MDMA and amphetamine increase emotional empathy without affecting cognitive empathy; MDMA simultaneously leads to elevated levels of oxytocin, unrelated to its behavioral effects. The aim of the present study was to assess the reported enhancement of empathy by 4-FA, to assess its effects on oxytocin, and to test potential associations between both...
October 25, 2018: Human Psychopharmacology
Laura Musetti, Antonio Tundo, Alessandra Benedetti, Gabriele Massimetti, Erika Cambiali, Irene Pergentini, Claudia Del Grande, Liliana Dell'Osso
OBJECTIVE: This study aims to describe the prescription patterns of the mood stabilizers most commonly used for the treatment of bipolar I and II disorders (lithium, valproate, and carbamazepine) and to analyze the treatment outcomes. METHODS: Two hundred and thirty-four outpatients with bipolar disorders receiving prophylactic treatment with lithium, valproate, carbamazepine, or their combination were followed up for at least 18 months in two Italian psychiatric centers specialized in mood disorders...
October 12, 2018: Human Psychopharmacology
Merve Demirbugen Oz, Zuhal Uckun, Nazan Yuce-Artun, Bora Baskak, Hatice Ozdemir, Tugba Kizil Ozel, Halise Devrimci Ozguven, H Sinan Suzen
OBJECTIVE: The aim of the present study was to determine the relationship between the polymorphisms of -1438A/G and 102T/C in the 5-HT2A receptor (HTR2A) gene and nausea/vomiting as a side effect induced by sertraline (SERT) or citalopram (CIT) in patients with major depressive disorder. METHODS: A total of 128 patients were enrolled, 63 patients received CIT, whereas 65 patients were treated with SERT. Nausea/vomiting were assessed with the UKU Side-effects Rating Scale at baseline and at the end of the second and fourth weeks...
September 17, 2018: Human Psychopharmacology
Ndaba Mazibuko, Mitul A Mehta
OBJECTIVE: Recent efforts to optimise translation of basic research findings to successful clinical trials have led to a sharper focus on experimental medicine translational studies. This is coupled with a movement towards greater methodological integrity and openness. Although this can be achieved through preregistration and detailed reporting of study methodology, the reality of study application can often be lost. METHODS: In practice, challenges in study application can often lead to diminished scientific robustness, even in well-designed studies...
September 2018: Human Psychopharmacology
Peter van Ruitenbeek, Dennis Hernaus, Mitul Ashok Mehta
OBJECTIVE: Cognitive deficits including impaired working memory are a hallmark feature of schizophrenia. Dopamine D1 receptor modulated changes in prefrontal cortex function play a potentially important role in the pathology underlying such deficits. However, pharmacological interventions that selectively engage the D1 receptor are severely restricted for research in humans. The present study is a proof-of-principle for enhancing cognitive performance and associated brain activation via indirect D1 stimulation, operationalised by combining the nonselective dopamine agonist L-dopa with the D2-antagonist haloperidol...
September 2018: Human Psychopharmacology
Amanda J Lisoway, Gwyneth Zai, Arun K Tiwari, Clement C Zai, Karen Wigg, Vanessa Goncalves, Danning Zhang, Natalie Freeman, Daniel J Müller, James L Kennedy, Margaret A Richter
OBJECTIVES: A recent genome-wide association study (GWAS) in obsessive-compulsive disorder (OCD) reported a significant marker in the dispatched homolog 1 (Drosophila) gene (DISP1 gene) associated with serotonin reuptake inhibitor (SRI) antidepressant response (Qin et al., ). DISP1 has never been examined before in terms of association with SRI response until this GWAS. We attempt to replicate the GWAS finding by investigating the association of the DISP1 rs17162912 polymorphism with SRI response in our sample of 112 European Caucasian OCD patients...
July 2018: Human Psychopharmacology
Robert Ross MacLean, Andrew J Waters, Emily Brede, Mehmet Sofuoglu
OBJECTIVE: Drugs that enhance cholinergic transmission have demonstrated promise treating addictive disorders. Galantamine, an acetylcholinesterase inhibitor, may reduce cigarette smoking in otherwise healthy treatment-seeking smokers. METHODS: The current study is a double-blind, placebo-controlled, study that randomized daily smokers (n = 60) to receive one of two doses of galantamine extended release (8 or 16 mg/day), or a placebo treatment. Participants completed a smoking choice task as well as study measures and cognitive tasks in the laboratory and daily life using ecological momentary assessment...
July 2018: Human Psychopharmacology
Alireza Ghajar, Faezeh Gholamian, Maryam Tabatabei-Motlagh, Mohsen Afarideh, Farzin Rezaei, Maryam Ghazizadeh-Hashemi, Shahin Akhondzadeh
OBJECTIVE: We aimed to evaluate the efficacy and tolerability of citicoline add-on therapy in treatment of negative symptoms in patients with stable schizophrenia. METHODS: In a double-blind and placebo-controlled study, patients with stable schizophrenia (DSM-5) were randomized to receive either 2,500 mg/day citicoline or placebo in addition to risperidone for 8 weeks. The patients were assessed using the positive and negative syndrome scale (PANSS), the extrapyramidal symptom rating scale (ESRS), and Hamilton depression rating scale (HDRS)...
July 2018: Human Psychopharmacology
Ashley N Linden-Carmichael, Amy L Stamates, Cecile A Marczinski, Cathy Lau-Barraco
No abstract text is available yet for this article.
July 2018: Human Psychopharmacology
Andrew Scholey, Sarah Benson, Sean Johnson, Chris Alford, Samuel Benrejeb Godefroy, Joris C Verster
No abstract text is available yet for this article.
July 2018: Human Psychopharmacology
Stefan Jongen, Nick N J J M van der Sluiszen, Dennis Brown, Eric F P M Vuurman
Driving experience and alcohol are two factors associated with a higher risk of crash involvement in young novice drivers. Driving a car is a complex task involving multiple tasks leading to dividing attention. The aim of this study was to compare the single and combined effects of a low and moderate dose of alcohol on single- and dual-task performance between young novice and more experienced young drivers during actual driving. Nine healthy novice drivers were compared with 9 more experienced drivers in a three-way, placebo-controlled, cross-over study design...
May 2018: Human Psychopharmacology
Walter Roberts, Terril L Verplaetse, Kelly E Moore, Lindsay M Oberleitner, Sherry A McKee
OBJECTIVE: To test the effects of doxazosin, an α1 antagonist, on cognitive functioning during tobacco withdrawal in smokers. METHODS: Participants (n = 35) were randomly assigned to receive placebo, 4-mg/day, or 8-mg/day doxazosin. They completed a continuous performance task and self-reported their withdrawal symptoms at baseline and twice following a medication titration period: once in a tobacco-deprived state and again in a nondeprived state. Ability to resist smoking was assessed using a laboratory smoking-lapse paradigm...
May 2018: Human Psychopharmacology
Paolo Girardi, Antonio Del Casale, Chiara Rapinesi, Georgios D Kotzalidis, Francesca Splendori, Claudio Verzura, Giada Trovini, Serena Sorice, Dario Carrus, Iginia Mancinelli, Anna Comparelli, Sergio De Filippis, Antonio Francomano, Andrea Ballerini, Andrea Marcellusi, Francesco S Mennini, Giuseppe Ducci, Gabriele Sani, Maurizio Pompili, Roberto Brugnoli
BACKGROUND: Long-acting injectable (LAI) antipsychotics can improve medication adherence and reduce hospitalisation rates compared with oral treatments. Paliperidone palmitate (PAL) and aripiprazole monohydrate (ARI) LAI treatments were associated with improvements in global functioning in patients with schizophrenia. OBJECTIVE: The objective of this study was to assess the predictive factors of better overall functioning in patients with chronic schizophrenia and schizoaffective disorder treated with PAL and ARI...
May 2018: Human Psychopharmacology
Christopher J Hodges, Rowan P Ogeil, Dan I Lubman
OBJECTIVES: Although sleep disturbances are prominent during alcohol withdrawal, less is known about the specific components of sleep that are disturbed prior to and during acute detoxification. This study aimed to determine whether specific sleep components are affected prior to and during acute detoxification and their relationship to psychological distress. METHODS: Twenty-nine participants were recruited from a residential detoxification service in Melbourne, Australia, and completed both subjective methods of sleep and distress, in addition to wearing an actigraphy device...
May 2018: Human Psychopharmacology
Minling Zhang, Hongbo He, Yuping Ning, Yi Ding, Xiaoyin Ke, Daping Wang, Xuefeng Deng, Ni Fan
BACKGROUND: Growth factors play an important role in brain development. Whether epidermal growth factor (EGF) plays a role in the pathophysiology of ketamine related disorders is unexplored. In this study, we examined the serum levels of EGF in chronic ketamine users as compared with healthy controls. The possible correlation between serum EGF levels with the demographic, ketamine use characteristics and psychopathological symptoms were analyzed. METHODS: Sixty-seven chronic ketamine users and 40 healthy subjects were recruited...
May 2018: Human Psychopharmacology
Asuka Kikuchi, Fairuz Binti Mohammadi Nasir, Akie Inami, Attayeb Mohsen, Shoichi Watanuki, Masayasu Miyake, Kazuko Takeda, Daigo Koike, Takayasu Ito, Junpei Sasakawa, Rin Matsuda, Kotaro Hiraoka, Marcus Maurer, Kazuhiko Yanai, Hiroshi Watabe, Manabu Tashiro
OBJECTIVE: Antihistamines often have sedative side effects. This was the first study to measure regional cerebral glucose (energy) consumption and hemodynamic responses in young adults during cognitive tests after antihistamine administration. METHODS: In this double-blind, placebo-controlled, three-way crossover study, 18 healthy young Japanese men received single doses of levocetirizine 5 mg and diphenhydramine 50 mg at intervals of at least six days. Subjective feeling, task performances, and brain activity were evaluated during three cognitive tests (word fluency, two-back, and Stroop)...
March 2018: Human Psychopharmacology
Samson W Duresso, Allison J Matthews, Stuart G Ferguson, Raimondo Bruno
OBJECTIVE: This study aimed to determine the efficacy of the Severity of Dependence Scale (SDS) as a screening tool for Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition-defined khat use disorder. METHODS: Cross-sectional, purposive sample of past-year khat consumers aged 16 and above were recruited from khat markets and cafes from university and general community in Adama, Ethiopia. Participants self-completed a survey comprising current substance use disorder...
March 2018: Human Psychopharmacology
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