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Digestive Diseases

Dor Shirin, Noam Peleg, Orly Sneh-Arbib, Michal Cohen-Naftaly, Marius Braun, Tzipora Shochat, Assaf Issachar, Amir Shlomai
BACKGROUND: Patients with nonalcoholic fatty liver disease (NAFLD) and with abnormal liver function tests (LFTs) most commonly present with elevated hepatocellular enzymes (H pattern), but a subset of patients is found to have elevated cholestatic enzymes (C pattern) or a mixed (M) pattern. AIMS AND METHODS: To determine whether the epidemiologic background and comorbidities, as well as the degree of liver fibrosis, differ between NAFLD patients with different patterns of elevated LFTs by retrospectively analyzing data of 106 patients with a biopsy-proven diagnosis of NAFLD...
July 17, 2018: Digestive Diseases
Nurit Loberman-Nachum, Michael Schvimer, Camila Avivi, Iris Barshack, Avishay Lahad, Akiva Fradkin, Yoram Bujanover, Batia Weiss
BACKGROUND: The clinical, histological, and serological spectrum of celiac disease (CD) vary widely. We aimed to examine relationships between symptoms, serum anti-tissue transglutaminase antibodies (tTG) levels, mucosal damage, and mucosal anti-tTG deposits in pediatric CD. METHODS: A retrospective single-center, cohort study of children referred for endoscopy with suspected CD during 2011-2014. We retrieved the clinical data, blindly reviewed duodenal biopsies, and performed immunohistochemical staining for anti-tTG deposits...
July 17, 2018: Digestive Diseases
Roger F Butterworth, Ali Canbay
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is the leading chronic hepatic condition worldwide and new approaches to management and treatment are limited. SUMMARY: L-ornithine L-aspartate (LOLA) has hepatoprotective properties in patients with fatty liver of diverse etiology and results of a multicenter randomized clinical trial reveal that 12 weeks treatment with oral LOLA (6-9 g/d) results in a dose-related reduction in activities of liver enzymes and triglycerides together with significant improvements of liver/spleen CT ratios...
July 17, 2018: Digestive Diseases
Larisse Longo, Laura Bainy Rodrigues de Freitas, Deivid Santos, Ivana Grivicich, Mário Reis Álvares-da-Silva
INTRODUCTION: Sorafenib (SOR) has proved to be effective in patients with advanced hepatocellular carcinoma (HCC), since overall survival was higher in phase III clinical trials; however, disease progression can occur. OBJECTIVES: The study aimed to describe real-life experience in advanced HCC treatment with SOR at a university hospital in Brazil and to estimate the number of patients with indication of second-line therapy. METHODS: This is a retrospective study that included cases of HCC with prescription of SOR based on real-life practice between 2011 and 2016...
July 13, 2018: Digestive Diseases
Annalisa Capannolo, Fabiana Ciccone, Giovanni Latella
BACKGROUND: Chronic diarrhoea affects 5-10% of the adult population. Histologic lesions of possible diagnostic significance are found under normal colonoscopy in approximately 30% of patients affected by chronic diarrhoea. Mastocytic enterocolitis is characterized by an increase in the number of mucosal mast cells (MC) in the gut of patients with chronic intractable diarrhoea, detected by immunohistochemical staining, responding to mast-cell targeted drugs. The question arises whether to search for MC infiltration in specific subsets of patients as a matter of routine clinical practice...
July 6, 2018: Digestive Diseases
(no author information available yet)
No abstract text is available yet for this article.
July 5, 2018: Digestive Diseases
Jin Lee, Joo Wan Seo, Ho Chan Sim, Joon Hyuk Choi, Nae-Yun Heo, Jongha Park, Seung Ha Park, Young Soo Moon, Tae Oh Kim
OBJECTIVES: Surveillance colonoscopy is recommended after polypectomy because adenoma recurrence is common. The aim of this study was to evaluate the predictors of high-risk adenoma occurrence at surveillance colonoscopy in patients who undergo colorectal adenoma removal and to clarify the association between age and recurrent colorectal adenoma. METHODS: This retrospective study included 563 patients who had colorectal adenomas at baseline colonoscopy and who underwent surveillance colonoscopy...
July 3, 2018: Digestive Diseases
Laurent Peyrin-Biroulet, Daniel C Baumgart, Alessandro Armuzzi, Paolo Gionchetti, Shaji Sebastian, Silvio Danese, Fernando Magro, Sophie Higgins, Andrew Yaworksy, Benjamin Banderas, Sumesh Kachroo
OBJECTIVES: To establish clinical consensus on important and relevant quality-of-care (QoC) attributes in ulcerative colitis (UC) treatment that may improve treatment outcomes and guide best practices. METHODS: Thirty-eight QoC attributes were identified in a literature review. Sixteen European-based experts were selected based on their contributions to UC guidelines, publications, and patient care. A 3-round, modified Delphi panel was conducted including an interview round, and 2 web-based rounds to reach consensus and finalize a QoC attribute list...
July 3, 2018: Digestive Diseases
Yujiro Nishioka, Junichi Shindoh, Yoshinori Inagaki, Wataru Gonoi, Jun Mitsui, Hiroyuki Abe, Ryuji Yoshioka, Shuntaro Yoshida, Masashi Fukayama, Shoji Tsuji, Masaji Hashimoto, Kiyoshi Hasegawa, Norihiro Kokudo
BACKGROUND: Understanding the genetic background of a tumor is important to better stratify patient prognosis and select optimal treatment. For colorectal liver metastases (CLM), however, clinically available biomarkers remain limited. METHODS: After a comprehensive sequencing of 578 cancer-related genes in 10 patients exhibiting very good/poor responses to chemotherapy, the A5.1 variant of the MICA gene was selected as a potential biomarker for CLM. The clinical relevance of MICA A5...
July 3, 2018: Digestive Diseases
Mitsuhiro Furuta, Michihisa Moriguchi, Keiichiro Okuda, Seita Kataoka, Naoki Mizuno, Masashi Takemura, Hiroyoshi Taketani, Tasuku Hara, Yuya Seko, Atsushi Umemura, Taichiro Nishikawa, Kanji Yamaguchi, Koichiroh Yasui, Masahito Minami, Yoshito Itoh
AIM: In Japan, transcatheter arterial chemoembolization (TACE) refractoriness for hepatocellular carcinoma has been defined as an insufficient therapeutic effect after ≥2 procedures. Insufficient TACE for intrahepatic lesions is defined as the presence of > 50% viable lesions (ineffective) or an increase in their number (progressive). This study aimed to examine the possibility of earlier evaluation of TACE refractoriness. METHODS: Patients who underwent TACE for hepatocellular carcinomas > 3 cm in size or with > 3 nodules at our hospital between 2010 and 2014 were analyzed...
July 3, 2018: Digestive Diseases
Winesh Ramphal, Jennifer M J Schreinemakers, Tom C J Seerden, Paul D Gobardhan
BACKGROUND: The association between diverticulitis and colorectal cancer (CRC) remains unclear, though both share epidemiological characteristics. The aim of this study was to investigate whether there is higher risk for CRC after an episode of uncomplicated diverticulitis. Furthermore, in cases of CRC, we sought to determine specific tumour characteristics. METHODS: This retrospective observational study includes patients with acute diverticulitis (Hinchey 0 and 1) who were conservatively treated with or without antibiotics between 2008 and 2013...
June 26, 2018: Digestive Diseases
Christos Liatsos, Theodore Rokkas
No abstract text is available yet for this article.
June 6, 2018: Digestive Diseases
Moon Kyung Joo, Jong-Jae Park, Hoon Jai Chun
No abstract text is available yet for this article.
June 6, 2018: Digestive Diseases
Ali Aghdassi, Agnes Christoph, Frank Dombrowski, Paula Döring, Christoph Barth, Jan Christoph, Markus M Lerch, Peter Simon
BACKGROUND AND AIMS: Gastrointestinal stromal tumors (GISTs) are rare malignancies but the most common mesenchymal tumors of the digestive tract. Recent advances in diagnostic imaging and an increasing incidence will confront us more frequently with stromal tumors. This single center study aimed to characterize GIST patients in terms of tumor location, clinical presentation, metastasis formation, as well as associated secondary malignancies. METHODS: In a retrospective study, 104 patients with a histologically confirmed diagnosis of GIST, collected between 1993 and 2011, were characterized for several clinical features...
June 5, 2018: Digestive Diseases
Richard Parker, James M Neuberger
BACKGROUND: Alcoholic hepatitis (AH) is a severe manifestation of alcohol-related liver disease characterised by jaundice and liver failure. It is not known what might trigger an episode of AH. We interviewed patients to investigate changes in behaviour before the onset of AH. METHODS: Structured interviews were performed with patients with AH to examine their alcohol use, diet, drug use and smoking habit. Clinical and laboratory results were noted. Patients were followed up for 12 months after interview...
May 31, 2018: Digestive Diseases
Kazuto Tajiri, Yoshiharu Tokimitsu, Hiroyuki Ito, Yoshinari Atarashi, Kengo Kawai, Masami Minemura, Satoshi Yasumura, Terumi Takahara, Yukihiro Shimizu, Toshiro Sugiyama
AIMS: The study aimed to evaluate the effects of tolvaptan treatment on survival of patients with decompensated liver cirrhosis with refractory ascites. METHODS: This multicenter, retrospective, observational study included patients with cirrhosis who were treated with tolvaptan for hepatic ascites refractory to conventional diuretics. Patients who could and could not decrease accompanying diuretics within 1 month after tolvaptan administration were defined as the "Decreased" and "Not-decreased" groups, respectively...
May 31, 2018: Digestive Diseases
Doron Boltin, Ibrahim Zvidi, Maria Raskin, Hen Kayless, Hemda Schmilovitz-Weiss, Rachel Gingold-Belfer, Yaron Niv, Ram Dickman
BACKGROUND: Esomeprazole is commonly administered with food; however, clinical data to support this practice are lacking. We aimed to determine the effect of postprandial ingestion of esomeprazole on reflux symptoms among patients with gastroesophageal reflux disease (GERD). METHODS: Consecutive patients with GERD adequately controlled with esomeprazole 40 mg daily, entered a 2-week lead-in period during which esomeprazole was administered 30 min before breakfast...
May 23, 2018: Digestive Diseases
Yusaku Takatori, Motohiko Kato
No abstract text is available yet for this article.
May 23, 2018: Digestive Diseases
Antonio Ponzetto, Natale Figura, Alessia Ciancio
No abstract text is available yet for this article.
May 23, 2018: Digestive Diseases
Sven H Loosen, Mihael Vucur, Christian Trautwein, Christoph Roderburg, Tom Luedde
BACKGROUND: Cholangiocarcinoma (CCA) represents the second most common primary liver malignancy. The incidence rate has constantly increased over the last decades and CCA patients face a dismal prognosis with a 5-year survival rate of less than 5% for advanced stage of disease. Surgical tumor resection has remained the only potentially curative treatment option in daily practice but is often not feasible due to advanced disease stage at initial diagnosis. SUMMARY: The early detection of cholangiocarcinoma is essential to provide patients with a potentially curative treatment...
May 15, 2018: Digestive Diseases
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