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Digestive Diseases

Aline Gottlieb, Maren Kottmann, Paul Manka, Sotiria Bedreli, Johannes Hadem, Lars Bechmann, Jan-Peter Sowa, Guido Gerken, Ali Canbay
BACKGROUND: The definition of acute liver failure (ALF) usually implies no previous liver injury. Though, some patients admitted to liver transplantation centers with the diagnosis of ALF are obese or have diabetes. Elevated liver enzymes were not recorded previously, and no signs of cirrhosis or prior decompensation of the liver function were ever present. Still, these patients differ from the "typical" ALF-patient. GOALS: In this study, we aimed to confirm acute-on-chronic-liver failure (AOCLF) in patients diagnosed with ALF and to identify possible differences between ALF and AOCLF...
September 18, 2018: Digestive Diseases
Taro Iwatsubo, Yoji Takeuchi, Yasushi Yamasaki, Kentaro Nakagawa, Masamichi Arao, Masayasu Ohmori, Hiroyoshi Iwagami, Kenshi Matsuno, Shuntaro Inoue, Hiroko Nakahira, Noriko Matsuura, Satoki Shichijo, Akira Maekawa, Takashi Kanesaka, Sachiko Yamamoto, Koji Higashino, Noriya Uedo, Ryu Ishihara
BACKGROUND: Although the use of endoscopic submucosal dissection (ESD) as a minimally invasive treatment for large superficial colorectal neoplasms is increasing, colorectal ESD remains technically challenging. As perforation in the colorectum is generally considered to be associated with a higher risk of complications, the aim of this study was to investigate the characteristics of perforation caused by colorectal ESD. METHODS: This retrospective study included 635 lesions treated with colorectal ESD, between February 2011 and December 2015, in a tertiary cancer center...
September 18, 2018: Digestive Diseases
Ken Sugimoto, Kentaro Ikeya, Masaichi Kato, Ai Matsuura, Fumitoshi Watanabe, Ryosuke Takano, Satoshi Tamura, Shinya Tani, Satoshi Osawa, Hiroyuki Hanai
BACKGROUND: Although evidence for the short- to medium-term efficacy of adalimumab in ulcerative colitis (UC) patients is emerging, there are a limited number of reports on the long-term efficacy of adalimumab. This study was to understand baseline demographic features, which potentially could be risk factors for relapse or colectomy following induction of remission by adalimumab in UC patients. Additionally, factors affecting long-term outcomes were to be identified. METHODS: Twenty-one patients with UC who had been treated with adalimumab were reviewed retrospectively...
September 11, 2018: Digestive Diseases
Jun Takada, Hiroshi Araki, Taku Mizutani, Noritaka Ozawa, Tomohiko Sugiyama, Masaya Kubota, Takashi Ibuka, Masahito Shimizu
BACKGROUND: Pulmonary dysfunction often accompanies esophageal squamous cell carcinoma (SCC). AIMS: This study examined the use of carbon dioxide (CO2) insufflation and its safety during esophageal endoscopic submucosal dissection (ESD) while under conscious sedation. METHODS: ESD using CO2 insufflation (1.4 L/min) was performed in 102 consecutive esophageal SCC patients. Patients with a forced expiratory volume of 1.0 s/forced vital capacity (FEV1...
September 11, 2018: Digestive Diseases
Takeshi Ogura, Akira Miyano, Nobu Nishioka, Kazuhide Higuchi
Recently, due to improvement of imaging modality, malignant tumor such as pancreatic or bile duct cancer can be detected at earlier stage. Therefore, the frequency of surgical treatment may be increasing. According to this background, benign biliary stricture in anastomosis site may also be increasing. This complication can lead to repeated cholangitis, obstructive jaundice, or liver abscess. Traditionally, interventional radiology such as percutaneous transhepatic biliary drainage (PTCD) or surgical re-anastomosis may be the first choice of treatment for benign biliary stricture in anastomosis site...
August 28, 2018: Digestive Diseases
Bilge S Akkelle, Engin Tutar, Burcu Volkan, Ozlem K Sengul, Ahmet Ozen, Cigdem A Celikel, Deniz Ertem
BACKGROUND: It has been reported that 5-50% of patients with primary immune deficiencies (PID) may present with or develop gastrointestinal (GI) manifestations. OBJECTIVE: This study was aimed at analyzing GI and related endoscopic, histopathological findings in children with PID. METHODS: Children with PID who were evaluated by endoscopy between 2005 and 2016 were enrolled in this study. Demographic data, growth parameters, signs and symptoms at diagnosis were obtained...
August 28, 2018: Digestive Diseases
Thomas Thomaidis, Fareed Rahman, Florian Thieringer, Gian E Tontini, Klaus Mönkemüller, Sauid Ishaq, Peter R Galle, Helmut Neumann
BACKGROUND: Optical Enhancement technology (OE) combines bandwidth-limited light and image enhancement processing technology to enhance subtle mucosal and vascular details. This is the first study assessing the new technology for the diagnosis of gastroesophageal reflux disease (GERD). PATIENTS AND METHODS: Consecutive patients with GERD and controls were prospectively included. The distal esophagus was examined in all quadrants with high definition white-light endoscopy (HD-WLE) followed by OE and biopsies for histopathological analysis...
August 28, 2018: Digestive Diseases
Belén Beltrán, Marisa Iborra, Esteban Sáez-González, Maria R Marqués-Miñana, Inés Moret, Elena Cerrillo, Luis Tortosa, Guillermo Bastida, Joaquín Hinojosa, Jose Luis Poveda-Andrés, Pilar Nos
INTRODUCTION: The association between infliximab (IFX) and fecal calprotectin (FC) levels on one hand, and the clinical and endoscopic response of patients with inflammatory bowel disease on the other, is well established. OBJECTIVE AND METHODS: To investigate the association between inflammatory biochemical parameters and serum concentrations of IFX during induction treatment with a primary nonresponse in a prospective cohort of Crohn's disease (CD) patients. RESULTS: Of the 35 patients included, 8 (22...
August 27, 2018: Digestive Diseases
Peter Hoffmann, Johannes Krisam, Wolfgang Stremmel, Annika Gauss
BACKGROUND: Vedolizumab was approved for the therapy of ulcerative colitis and Crohn's disease in mid-2014. Real-world treatment data are necessary for a balanced assessment of its position among other therapeutic options. SUMMARY: Patients with ulcerative colitis or Crohn's disease, initiating vedolizumab therapy at the outpatient clinic for inflammatory bowel diseases at the University Hospital -Heidelberg between June 1, 2014 and August 31, 2016, were recruited based on electronic medical records...
August 22, 2018: Digestive Diseases
Nasser Ebrahimi Daryani, Maryam Sadr, Samaneh Soltani, Amene Saghazadeh, Shirin Moossavi, Sepideh Shahkarami, Elham Farhadi, Nima Rezaei
BACKGROUND: Inflammatory bowel disease (IBD) mostly comprised of Crohn's disease (CD) and ulcerative colitis (UC) is a condition arising from the combined effects of genetic, environmental, and immunological factors. IBD is associated with inflammation and altered cytokine profile. OBJECTIVE: This study was aimed at assessing the association between T helper type 1 (Th1) cytokine polymorphisms (interferon gamma [IFN-γ] +874 A/T, interleukin-12 [IL-12] -1188 A/C, IL-2 -330 G/T, IL-2 +166 G/T) and susceptibility to and clinical features of IBD...
August 22, 2018: Digestive Diseases
Isabelle Pauchard, Stéphane Nancey, Florence Hacard, Nicolas Williet, Xavier Roblin, Driffa Moussata, Frédéric Bérard, Bernard Flourié, Gilles Boschetti
BACKGROUND AND AIMS: One of the reasons for the failure of infliximab (IFX) is immediate hypersensitivity reactions (IHR). We aimed to report the efficacy and safety of a tolerance induction protocol in inflammatory bowel diseases (IBD) patients who had previously experienced IHR during IFX infusions. PATIENTS AND METHODS: We reported all cases of IBD patients who had previously experienced IHR due to IFX and who were submitted to a standardized protocol of tolerance induction to IFX from 2010 to 2015...
August 21, 2018: Digestive Diseases
Xiaoyan Pan, Yijing Han, Tiantian Zou, Guiqi Zhu, Ke Xu, Jina Zheng, Minghua Zheng, Xingbo Cheng
BACKGROUNDS AND AIMS: Previous studies have investigated that sarcopenia is associated with nonalcoholic fatty liver disease (NAFLD), nonalcoholic steatohepatitis, and fibrosis in NAFLD. The study aims to investigate the risk for NAFLD, especially NAFLD-related significant fibrosis among subjects with sarcopenia. METHODS: We searched electronic databases until 30, September 2017 and reviewed literature extensively. Effect estimates were pooled using random effect models regarding the risk for NAFLD and fixed effect models concerning the risk for significant fibrosis among sarcopenia patients...
July 26, 2018: Digestive Diseases
Navchetan Kaur, Sanjay K Bhadada, Ranjana W Minz, Devi Dayal, Rakesh Kochhar
BACKGROUND: A complex interplay between genetic and environmental factors contributes to disease etiology of most of the autoimmune disorders. Type 1 diabetes mellitus (T1DM) and celiac disease (CD) are polygenic autoimmune diseases that have high propensity to coexist due to shared etiological factors like genetics and clinico-pathological overlaps. SUMMARY: The mean prevalence rate for coexistence of these diseases is 8%, and this value is a gross underestimation as reported from biopsy-proven symptomatic cases...
July 25, 2018: Digestive Diseases
Dor Shirin, Noam Peleg, Orly Sneh-Arbib, Michal Cohen-Naftaly, Marius Braun, Tzipora Shochat, Assaf Issachar, Amir Shlomai
BACKGROUND: Patients with nonalcoholic fatty liver disease (NAFLD) and with abnormal liver function tests (LFTs) most commonly present with elevated hepatocellular enzymes (H pattern), but a subset of patients is found to have elevated cholestatic enzymes (C pattern) or a mixed (M) pattern. AIMS AND METHODS: To determine whether the epidemiologic background and comorbidities, as well as the degree of liver fibrosis, differ between NAFLD patients with different patterns of elevated LFTs by retrospectively analyzing data of 106 patients with a biopsy-proven diagnosis of NAFLD...
July 17, 2018: Digestive Diseases
Roger F Butterworth, Ali Canbay
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is the leading chronic hepatic condition worldwide and new approaches to management and treatment are limited. SUMMARY: L-ornithine L-aspartate (LOLA) has hepatoprotective properties in patients with fatty liver of diverse etiology and results of a multicenter randomized clinical trial reveal that 12 weeks treatment with oral LOLA (6-9 g/d) results in a dose-related reduction in activities of liver enzymes and triglycerides together with significant improvements of liver/spleen CT ratios...
July 17, 2018: Digestive Diseases
Annalisa Capannolo, Fabiana Ciccone, Giovanni Latella
BACKGROUND: Chronic diarrhoea affects 5-10% of the adult population. Histologic lesions of possible diagnostic significance are found under normal colonoscopy in approximately 30% of patients affected by chronic diarrhoea. Mastocytic enterocolitis is characterized by an increase in the number of mucosal mast cells (MC) in the gut of patients with chronic intractable diarrhoea, detected by immunohistochemical staining, responding to mast-cell targeted drugs. The question arises whether to search for MC infiltration in specific subsets of patients as a matter of routine clinical practice...
July 6, 2018: Digestive Diseases
(no author information available yet)
No abstract text is available yet for this article.
July 5, 2018: Digestive Diseases
Yujiro Nishioka, Junichi Shindoh, Yoshinori Inagaki, Wataru Gonoi, Jun Mitsui, Hiroyuki Abe, Ryuji Yoshioka, Shuntaro Yoshida, Masashi Fukayama, Shoji Tsuji, Masaji Hashimoto, Kiyoshi Hasegawa, Norihiro Kokudo
BACKGROUND: Understanding the genetic background of a tumor is important to better stratify patient prognosis and select optimal treatment. For colorectal liver metastases (CLM), however, clinically available biomarkers remain limited. METHODS: After a comprehensive sequencing of 578 cancer-related genes in 10 patients exhibiting very good/poor responses to chemotherapy, the A5.1 variant of the MICA gene was selected as a potential biomarker for CLM. The clinical relevance of MICA A5...
July 3, 2018: Digestive Diseases
Christos Liatsos, Theodore Rokkas
No abstract text is available yet for this article.
June 6, 2018: Digestive Diseases
Moon Kyung Joo, Jong-Jae Park, Hoon Jai Chun
No abstract text is available yet for this article.
June 6, 2018: Digestive Diseases
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