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Digestive Diseases

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https://www.readbyqxmd.com/read/29207381/alicaforsen-an-antisense-inhibitor-of-intercellular-adhesion-molecule-1-in-the-treatment-for-left-sided-ulcerative-colitis-and-ulcerative-proctitis
#1
Thomas Greuter, Stephan R Vavricka, Luc Biedermann, Julia Pilz, Jan Borovicka, Frank Seibold, Bernhard Sauter, Gerhard Rogler
BACKGROUND: Data on the efficacy of intercellular adhesion molecule-1 antisense oligonucleotide alicaforsen in ulcerative colitis (UC) is inconsistent. METHODS: All patients, who had received at least one dose of alicaforsen, were analyzed retrospectively. Alicaforsen's efficacy was assessed in patients treated for left-sided UC and proctitis by comparing clinical and (if applicable) endoscopic disease activity before/after treatment. RESULTS: Twelve patients were treated for left-sided UC or proctitis...
December 5, 2017: Digestive Diseases
https://www.readbyqxmd.com/read/29161702/favorable-effects-of-endoscopic-ligation-combined-with-drugs-on-rebleeding-and-mortality-in-cirrhotic-patients-a-network-meta-analysis
#2
Liang Shi, Xueping Zhang, Jianye Li, Xibo Bai
BACKGROUND: To assess the effects of combination therapies (endoscopic plus drug[s], drug combinations) on variceal/any-cause rebleeding and mortality among cirrhotic patients with one previous episode of variceal hemorrhage. SUMMARY: We searched PubMed, Embase, Cochrane Library, and Web of Science for eligible studies. We included 26 randomized controlled trials involving 2,536 adults using OR to measure the effects. Endoscopic variceal ligation (EVL) plus nadolol ranked first for reducing recurrent bleeds...
November 21, 2017: Digestive Diseases
https://www.readbyqxmd.com/read/29131053/an-experimental-study-to-measure-the-mechanical-properties-of-the-human-liver
#3
Alireza Karimi, Ahmad Shojaei
BACKGROUND: Since the liver is one of the most important organs of the body that can be injured during trauma, that is, during accidents like car crashes, understanding its mechanical properties is of great interest. Experimental data is needed to address the mechanical properties of the liver to be used for a variety of applications, such as the numerical simulations for medical purposes, including the virtual reality simulators, trauma research, diagnosis objectives, as well as injury biomechanics...
October 31, 2017: Digestive Diseases
https://www.readbyqxmd.com/read/29130971/can-the-ki-67-labeling-index-in-biopsy-specimens-predict-the-world-health-organization-grade-of-rectal-neuroendocrine-tumors
#4
Shinya Sugimoto, Kinichi Hotta, Tadakazu Shimoda, Kenichiro Imai, Sayo Ito, Yuichiro Yamaguchi, Kohei Takizawa, Naomi Kakushima, Masaki Tanaka, Noboru Kawata, Masao Yoshida, Hirotoshi Ishiwatari, Hiroyuki Matsubayashi, Hiroyuki Ono
BACKGROUND: Being grade 2 is a known risk factor for metastasis in rectal neuroendocrine tumors (R-NETs). We aimed to identify the efficacy of the Ki-67 labeling index (LI) in endoscopic biopsy specimens to predict the World Health Organization (WHO) grade of R-NETs. METHODS: A total of 59 patients with 60 R-NETs (43 WHO grade 1 and 17 WHO grade 2), treated between October 2002 and December 2014, were retrospectively evaluated. The patients included in the study underwent biopsies followed by endoscopic submucosal resection with a ligation device, trans-anal full-thickness surgical resection, or radical surgery with lymph node dissection...
October 31, 2017: Digestive Diseases
https://www.readbyqxmd.com/read/29050007/comparison-of-safety-and-efficacy-of-tacrolimus-versus-infliximab-for-active-ulcerative-colitis
#5
Ken Takeuchi, Takahiro Shimoyama, Takayuki Yamamoto
BACKGROUND: This narrative review was to determine which medication, tacrolimus (TAC) or infliximab (IFX), is safer and more effective in the management of active UC. Our literature search identified 5 studies directly comparing the outcomes of TAC versus IFX for active UC. A review of the 5 studies was undertaken. SUMMARY: The incidence of serious adverse events was not significantly different between the TAC and IFX groups. The short-term clinical remission and response rates and the colectomy-free rates were similar between the groups...
October 19, 2017: Digestive Diseases
https://www.readbyqxmd.com/read/29020680/hepatic-t-cell-tolerance-induction-in-an-inflammatory-environment
#6
Janine Dywicki, Fatih Noyan, Ana Clara Misslitz, Martin Hapke, Melanie Galla, Jerome Schlue, Roland S Liblau, Richard Taubert, Michael P Manns, Elmar Jaeckel, Matthias Hardtke-Wolenski
For the development of autoimmune hepatitis (AIH), genetic predisposition and environmental triggers are of major importance. Although experimental AIH can be induced in genetically susceptible mice, the low precursor frequency of autoreactive T cells hampers a deeper analysis of liver-specific T cells. Here, we established a system where the model antigen hemagglutinin (HA) is expressed exclusively in hepatocytes of Rosa26-HA mice following administration of a replication deficient adenovirus expressing Cre recombinase (Ad-Cre)...
October 12, 2017: Digestive Diseases
https://www.readbyqxmd.com/read/28982107/risk-factor-for-vital-signs-fluctuation-during-colonoscopy-under-conscious-sedation-consisting-of-midazolam-and-meperidine
#7
Shigeo Banno, Motohiko Kato, Yukie Sunata, Yuichiro Hirai, Yoko Kubosawa, Keiichiro Abe, Yoshiaki Takada, Tetsu Hirata, Yusaku Takatori, Michiko Wada, Satoshi Kinoshita, Hideki Mori, Kaoru Takabayashi, Masahiro Kikuchi, Toshio Uraoka
BACKGROUND: Sedatives or analgesics are widely used to relieve a patient's discomfort during colonoscopy (CS). Although cardiopulmonary adverse events are sometimes experienced during the examination, the risk factors for vital signs fluctuation (VSF) have not been fully elucidated. This study thus aimed to identify the risk factors for VSF during the examination, as well as to evaluate the frequency and the degree of VSF. SUMMARY: A total of 755 consecutive subjects who received CS under endoscopist-administrated sedation using midazolam, meperidine, or combination of both were retrospectively analyzed...
October 6, 2017: Digestive Diseases
https://www.readbyqxmd.com/read/28982106/pepsin-and-its-importance-for-functional-dyspepsia-relic-regulator-or-remedy
#8
Karl-Uwe Petersen
BACKGROUND: Functional dyspepsia is a heterogeneous disorder lacking an established therapeutic strategy. Historical treatment attempts with pepsin products were shrugged off, as a simple calculation shows that quantitative substitution is pointless. However, such attempts might have been right for the wrong reason. SUMMARY: Today, the role of pepsins is primarily seen in the provision of signalling amino acids (especially phenylalanine and tryptophan) and peptides, which initiate processes promoting digestion...
October 5, 2017: Digestive Diseases
https://www.readbyqxmd.com/read/28972951/task-shifting-in-surveillance-after-surgery-for-colorectal-cancer-addressing-the-right-question
#9
Kjetil Søreide
No abstract text is available yet for this article.
2018: Digestive Diseases
https://www.readbyqxmd.com/read/28965109/nonphysician-clinicians-in-the-follow-up-of-resected-patients-with-colorectal-cancer
#10
Robert R J Coebergh van den Braak, Zarina S Lalmahomed, Stefan Büttner, Bettina E Hansen, Jan N M Ijzermans
BACKGROUND/AIMS: The 5-year postoperative follow-up for patients undergoing curative treatment for colorectal cancer (CRC) is labour intensive. We assessed the added value of a dedicated nonphysician clinician (NPC) in the follow-up of patients after resection for CRC. METHODS: Patients were divided into 2 groups as defined by the number of follow-up visits in the first year, including intensive (≥3×) and minimal (≤2×). Involvement of an NPC, diagnosis of disease recurrence and the course of the disease were determined...
2018: Digestive Diseases
https://www.readbyqxmd.com/read/28881340/additional-benefits-of-routine-drugs-on-gastrointestinal-cancer-statins-metformin-and-proton-pump-inhibitors
#11
Moon Kyung Joo, Jong-Jae Park, Hoon Jai Chun
BACKGROUND: Commonly used medications including statins, metformin, and proton pump inhibitors (PPIs) effectively reduce the risk of esophageal, gastric, and colorectal cancer (CRC). SUMMARY: A number of observational studies and meta-analyses have shown that long-term statin use significantly reduces the incidence of gastrointestinal (GI) cancer. Moreover, statin use after GI cancer diagnosis has been significantly associated with better prognosis in large-scale cohort studies...
2018: Digestive Diseases
https://www.readbyqxmd.com/read/28866661/observational-study-of-perspectives-of-inflammatory-bowel-disease-patients-concerning-the-use-of-corticosteroids
#12
Sadaf Asl Baakhtari, Andrew McCombie, Sebastiaan Ten Bokkel Huinink, Peter Irving, Corey A Siegel, Roger Mulder, Chris J Mulder, Richard Gearry
AIM: We aimed to investigate the factors that make inflammatory bowel disease (IBD) patients more or less likely to be willing to take corticosteroids. METHODS: Respondents completed a questionnaire. The primary outcome was whether the respondents would or would not use corticosteroids again to treat their IBD. Three separate univariate and multivariate analyses were performed to examine which variables predicted willingness to take steroids, including specific side effects...
2018: Digestive Diseases
https://www.readbyqxmd.com/read/28817809/evaluation-of-infliximab-therapy-in-children-with-crohn-s-disease-using-trough-levels-predictors
#13
Jan Ohem, Ondrej Hradsky, Kristyna Zarubova, Ivana Copova, Petra Bukovska, Richard Prusa, Karin Malickova, Jiri Bronsky
BACKGROUND: In adults, infliximab (IFX) levels correlate with disease activity, and antibodies to IFX (ATIs) predict treatment failure. We aimed to determine the association of IFX levels and ATIs with disease activity in a paediatric population. We prospectively collected blood, stool, and clinical data from 65 patients (age 10.5-15.1 years) with Crohn's disease (CD) before IFX administration, and measured IFX trough levels, ATIs, and faecal calprotectin levels (CPT). Samples were collected during maintenance therapy...
2018: Digestive Diseases
https://www.readbyqxmd.com/read/28683448/gut-microbiota-in-health-diverticular-disease-irritable-bowel-syndrome-and-inflammatory-bowel-diseases-time-for-microbial-marker-of-gastrointestinal-disorders
#14
Loris Riccardo Lopetuso, Valentina Petito, Cristina Graziani, Elisa Schiavoni, Francesco Paroni Sterbini, Andrea Poscia, Eleonora Gaetani, Francesco Franceschi, Giovanni Cammarota, Maurizio Sanguinetti, Luca Masucci, Franco Scaldaferri, Antonio Gasbarrini
Few data exist on differences in gut microbiota composition among principal gastrointestinal (GI) diseases. We evaluated the differences in gut microbiota composition among uncomplicated diverticular disease (DD), irritable bowel syndrome (IBS) and inflammatory bowel diseases (IBD) patients. DD, IBS, and IBD patients along with healthy controls (CT) were enrolled in our Italian GI outpatient clinic. Stool samples were collected. Microbiota composition was evaluated through a metagenomic gene-targeted approach...
2018: Digestive Diseases
https://www.readbyqxmd.com/read/28683444/replication-protein-a-3-is-associated-with-hepatocellular-carcinoma-tumorigenesis-and-poor-patient-survival
#15
Wenbo Xiao, Jun Zheng, Baoyong Zhou, Long Pan
BACKGROUND: Replication protein A (RPA) 3 is a subunit of the RPA protein complex, which functions in multiple processes of DNA metabolism. Dysregulation of RPA1 and RPA2 has been implicated in tumor progression in several cancer types. However, the function of RPA3 in hepatocellular carcinoma (HCC) tumorigenesis has not been elucidated. METHOD: In this study, we investigated the function of RPA3 in HCC development by stably knocking down its expression using short hairpin RNA (shRNA) in HepG2 cell line, followed by cell proliferation, colony formation, soft agar, and invasion assays...
2018: Digestive Diseases
https://www.readbyqxmd.com/read/28675895/impact-of-individual-components-of-the-metabolic-syndrome-on-the-outcome-of-patients-with-advanced-hepatocellular-carcinoma-treated-with-sorafenib
#16
Christian Labenz, Vera Prenosil, Sandra Koch, Yvonne Huber, Jens U Marquardt, Jörn M Schattenberg, Peter R Galle, Arndt Weinmann, Marcus-Alexander Wörns
BACKGROUND/AIM: Individual components of the metabolic syndrome (MS) such as obesity or diabetes mellitus impair the prognosis of patients with hepatocellular carcinoma (HCC) following curative treatment approaches or transarterial therapies. The aim of this retrospective study was to assess the impact of these factors on the overall survival (OS) of patients with advanced HCC treated with sorafenib. METHODS: Univariate and multivariate analyses were performed to assess the impact of individual components of the MS on the OS of 152 consecutive patients with advanced HCC treated with sorafenib...
2018: Digestive Diseases
https://www.readbyqxmd.com/read/28654928/risk-stratification-of-patients-with-crohn-s-disease-a-retrospective-analysis-of-clinical-decision-making-and-its-impact-on-long-term-outcome
#17
Mahmoud Mosli, Hanadi Sabbahi, Hind Alyousef, Mada Abdulhaq, Afnan Hadadi, Emad Aljahdali, Hani Jawa, Salem Bazarah, Yousif Qari
BACKGROUND AND AIMS: Complications such as need for bowel resections and hospitalization due to Crohn's disease (CD) occur when disease activity persists due to ineffective therapy. Certain "high-risk" features require an early introduction of anti-tumor necrosis factor-α therapy to prevent such complications. We aim to evaluate the prevalence of "high-risk" features among a cohort of patients with CD and examine the association between discordance of early therapy with baseline risk stratification and disease outcome...
2018: Digestive Diseases
https://www.readbyqxmd.com/read/28595197/high-serum-pepsinogen-i-and-beta-helicobacter-pylori-infection-are-risk-factors-for-aspirin-induced-gastroduodenal-injury
#18
Jing Shan, Hongjun Lei, Wei Shi, Xiaobin Sun, Yu Tang, Chunrong Ren
BACKGROUND: Whether gastric hyperchlorhydria and Helicobacter pylori infection contribute to aspirin-induced gastroduodenal injury still lacks evidence. Because serum pepsinogens (PGs) and gastrin-17 (G17) can reflect gastric acid secretion, this study intended to elucidate whether serum PGs, serum G17, and H. pylori infection are associated with aspirin-induced gastrointestinal injury. SUMMARY: A total of 60 patients taking low-dose aspirin for more than 1 month were enrolled in this study...
2018: Digestive Diseases
https://www.readbyqxmd.com/read/28595172/routine-pouchoscopy-prior-to-ileostomy-takedown-may-not-be-necessary-in-patients-with-chronic-ulcerative-colitis
#19
Jennifer X Cai, Jasmine Barrow, Alyssa Parian, Steven R Brant, Sharon Dudley-Brown, Jonathan Efron, Sandy Fang, Susan Gearhart, Michael Marohn, Bashar Safar, Brindusa Truta, Elizabeth Wick, Mark Lazarev
BACKGROUND: Creation of a J pouch is the gold standard surgical intervention in the treatment of chronic ulcerative colitis (UC). Pouchoscopy prior to ileostomy takedown is commonly performed. We describe the frequency, indication, and findings on pouchoscopy, and determine if pouchoscopy affects rates of complications after takedown. METHODS: All UC or indeterminate inflammatory bowel disease patients with a J pouch were retrospectively evaluated from January 1994 to December 2014...
2018: Digestive Diseases
https://www.readbyqxmd.com/read/28903095/injury-resistance-in-the-setting-of-liver-fibrosis-is-accompanied-by-the-inhibition-of-high-mobility-group-box-1-translocation-and-release
#20
Li Bai, Waishu Jin, Ming Kong, Xiaohui Zhang, Sujun Zheng, Yu Chen, Lu Li, Hui Liu, Longdong Zhu, Feng Ren, Junfeng Li, Yuanping Han, Zhongping Duan
BACKGROUND: Injury resistance occurring in the setting of liver fibrosis is an interesting phenomenon not yet well characterized. In the present study, we investigated dynamically the injury resistance against acute challenge using animal models of hepatic fibrosis and spontaneous resolution, and focused on high-mobility group box-1 (HMGB1), an important proinflammatory mediator. METHODS: The hepatic damage of control, fibrosis (CCl4, 6 weeks), and regressive mice with or without CCl4 challenge was dynamically observed and compared...
September 14, 2017: Digestive Diseases
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