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Digestive Diseases

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https://www.readbyqxmd.com/read/29466790/elevated-faecal-calprotectin-levels-are-a-reliable-non-invasive-screening-tool-for-small-bowel-crohn-s-disease-in-patients-undergoing-capsule-endoscopy
#1
Hamid Yousuf, Umair Aleem, Roisin Egan, Pardeep Maheshwari, Jafaar Mohamad, Deidre McNamara
BACKGROUND: Approximately 10% of Crohn's disease (CD) patients have this disease affecting the small bowel (SB) beyond the reach of Ileo-colonoscopy. Capsule endoscopy (SBCE) is the recommended investigation for SB disease. An accurate and inexpensive biomarker would help identify at-risk patients. AIM: To examine the efficacy of faecal calprotectin (FC) and C-reactive protein (CRP) as predictors of SBCE findings in suspected and known CD. METHODS: A prospective observational study...
February 21, 2018: Digestive Diseases
https://www.readbyqxmd.com/read/29421817/stw-5-iberogast-therapy-in-gastrointestinal-functional-disorders
#2
Peter Malfertheiner
Functional gastrointestinal disorders (FGIDs) are very common and affect populations worldwide. A majority of patients are affected by a variety of heterogenous gastrointestinal symptoms (GIS) related to the upper and lower digestive system with frequent overlap and mostly of mild to moderate degree. The herbal medicinal preparation STW 5 is documented as an effective therapeutic option for treating FGID. Studies Conducted in Summary: STW 5 has been in use for more than 50 years in clinical practice and proven to be effective and safe in the management of FGID...
February 8, 2018: Digestive Diseases
https://www.readbyqxmd.com/read/29421816/b1a-lymphocytes-cd19-cd5-deficiency-in-patients-with-crohn-s-disease-and-its-relation-with-disease-severity
#3
Rafael Gil-Borras, Carlos García-Ballesteros, Carmen Benet-Campos, Ignacio Catalán-Serra, Francisca López-Chuliá, Carmen Cuéllar, Juan Carlos Andreu-Ballester
BACKGROUND/AIMS: B1a cells (CD19+CD5+) are considered elements of the innate immune system. The aim of this study was to evaluate the frequency of B1a cells in the peripheral blood of patients with Crohn's disease (CD) and its relation with disease severity. METHODS: In this prospective study, a total of 128 subjects (64 CD patients and 64 healthy controls) were studied. B1a cells in peripheral blood, CD Activity Index, and Simple Endoscopic Score of B1a cells were studied...
February 8, 2018: Digestive Diseases
https://www.readbyqxmd.com/read/29421815/prelims
#4
(no author information available yet)
No abstract text is available yet for this article.
February 8, 2018: Digestive Diseases
https://www.readbyqxmd.com/read/29421814/herbal-preparation-stw-5-for-functional-gastrointestinal-disorders-clinical-experience-in-everyday-practice
#5
Tatiana L Lapina, Alexander S Trukhmanov
BACKGROUND: The most common functional gastrointestinal disorders (FGID) are functional dyspepsia (FD) and irritable bowel syndrome (IBS), with a prevalence in the general population of 15-20% (FD) and 10% (IBS), respectively. The complexity of pathophysiologic mechanisms and limitations in therapeutic options make the management of FD and IBS patients a challenge in routine clinical practice. SUMMARY: Syndromes classified as FGID frequently overlap, and coexist with gastroesophageal reflux disease (GERD)...
February 8, 2018: Digestive Diseases
https://www.readbyqxmd.com/read/29421808/pathophysiology-of-functional-gastrointestinal-disorders-a-holistic-overview
#6
Gerald Holtmann, Ayesha Shah, Mark Morrison
Background and Summary: Traditionally, functional gastrointestinal disorders (FGID), including functional dyspepsia or irritable bowel syndrome (IBS), are defined by more or less specific symptoms and the absence of structural or biochemical abnormalities that cause these symptoms. This concept is now considered to be outdated; if appropriate tests are applied, structural or biochemical abnormalities that explain or cause the symptoms may be found in many patients. Another feature of FGID are the highly prevalent psychiatric comorbidities, such as depression and anxiety...
February 8, 2018: Digestive Diseases
https://www.readbyqxmd.com/read/29421797/functional-gastrointestinal-disorders-complex-treatments-for-complex-pathophysiological-mechanisms
#7
Fermin Mearin, Peter Malfertheiner
No abstract text is available yet for this article.
February 8, 2018: Digestive Diseases
https://www.readbyqxmd.com/read/29421793/phytotherapy-in-functional-gastrointestinal-disorders
#8
Olaf Kelber, Rudolf Bauer, Wolfgang Kubelka
BACKGROUND: Phytotherapy is an important therapeutic option in functional gastrointestinal diseases (FGID). It has a large tradition, with different approaches in different regions of the world, some of which have made their way into modern evidence-based medicine (EBM). SUMMARY: Taking into account the number of herbs in use, and also the cumulated scientific evidence on them, FGID are possibly the most important indication in phytotherapy. This does not only apply for European phytotherapy, but also for other regions, such as Asia...
February 8, 2018: Digestive Diseases
https://www.readbyqxmd.com/read/29421792/functional-dyspepsia-and-irritable-bowel-syndrome-beyond-rome-iv
#9
Vincenzo Stanghellini
BACKGROUND: The correct diagnosis of functional gastrointestinal disorders (FGIDs) is quite a challenge. The overlaps between syndromes can complicate the interpretation of clinical data. SUMMARY: The incidence of functional digestive disorders and irritable bowel syndrome are still underestimated with the currently applied diagnostic tools, and the management of the seemingly elusive disease is not satisfactory. For this reason, the "Rome" criteria were created to provide a better understanding and classification of FGIDs...
February 8, 2018: Digestive Diseases
https://www.readbyqxmd.com/read/29421789/mechanism-of-action-of-stw%C3%A2-5-in-functional-dyspepsia-and-ibs-the-origin-of-multi-target
#10
Hans-Dieter Allescher, Heba Abdel-Aziz
BACKGROUND: STW 5 is a complex herbal combination preparation composed of 9 different herbal extracts. As an herbal medicinal product, this preparation is indicated for treating functional dyspepsia (FD) and irritable bowel syndrome (IBS). Its efficacy and practical applicability was demonstrated in several clinical studies. SUMMARY: Each herbal constituent of STW 5 has distinct effects on the gastrointestinal tract, and each shows activity through different mechanisms of action: among others, the single extracts have effects on nerves, smooth muscles, epithelial, and inflammatory cells...
February 8, 2018: Digestive Diseases
https://www.readbyqxmd.com/read/29421785/author-index-subject-index
#11
(no author information available yet)
No abstract text is available yet for this article.
February 8, 2018: Digestive Diseases
https://www.readbyqxmd.com/read/29353268/non-invasive-diagnostic-criteria-for-hepatocellular-carcinoma-in-hepatitis-b-virus-endemic-areas-is-cirrhosis-indispensable
#12
Xiao-Wen Huang, Bing Liao, Yang Huang, Jin-Yu Liang, Quan-Yuan Shan, Shun-Li Shen, Xiao-Yan Xie, Ming-de Lu, Li-da Chen, Wei Wang
AIM: To confirm whether cirrhosis is indispensable for the non-invasive diagnostic criteria for hepatocellular carcinoma (HCC) in hepatitis B virus (HBV)-endemic areas. METHODS: Between January 2014 and December 2014, a total of 409 patients with pathologically proven focal liver lesions who underwent contrast-enhanced ultrasound (CEUS) were recruited from our institution. Clinical liver cirrhosis, HBV/HCV infection and HCC-typical vascular pattern of the targeted lesion on CEUS were evaluated...
January 19, 2018: Digestive Diseases
https://www.readbyqxmd.com/read/29342468/the-role-of-history-of-gastro-duodenal-ulcer-in-patients-with-upper-gastrointestinal-bleeding
#13
Yusaku Takatori, Motohiko Kato, Yukie Sunata, Yuichiro Hirai, Yoko Kubosawa, Keichiro Abe, Yoshiaki Takada, Tetsu Hirata, Shigeo Banno, Michiko Wada, Satoshi Kinoshita, Hideki Mori, Kaoru Takabayashi, Miho Kikuchi, Masahiro Kikuchi, Masayuki Suzuki, Toshio Uraoka
BACKGROUND: Some scoring systems have been introduced to predict the need for performing urgent endoscopy in patients with upper gastrointestinal bleeding (UGIB). However, in an emergency situation, this intervention is insufficient and cannot easily provide the required treatment. AIM: To identify new risk factors that can predict the need for endoscopic intervention (EI) in UGIB patients. METHODS: This is a retrospective cross-sectional study...
January 17, 2018: Digestive Diseases
https://www.readbyqxmd.com/read/29342455/endoscopic-full-thickness-resection-of-a-colonic-lateral-spreading-tumor
#14
Ana-Maria Bucalau, Arnaud Lemmers, Marianna Arvanitakis, Daniel Blero, Horst Neuhaus
The Full-Thickness Resection Device (FTRD; Ovesco Endoscopy, Tübingen, Germany) combines endoscopic full-thickness resection (EFTR) of gastrointestinal lesions with closure and cutting of the tissue in one integrated procedure. It provides en-bloc resection with an integral wall specimen for histopathological evaluation. This resection technique is partially filling of the gaps between the current procedures of choice in endoscopy (endoscopic mucosal resection and endoscopic submucosal dissection) and surgery...
January 17, 2018: Digestive Diseases
https://www.readbyqxmd.com/read/29339645/multi-matrix-system-mesalazine-plus-rectal-mesalazine-in-the-treatment-of-mild-to-moderately-active-ulcerative-proctitis
#15
Antonio Cuomo, Dolores Sgambato, Mauro Valeriano D'Auria, Agnese Miranda, Emanuele Ferrante, Marco Romano
BACKGROUND: Mesalazine 1 g suppository/die is used for mild to moderately active ulcerative proctitis (UP). Whether addiction of Multi Matrix System (MMX) mesalazine increases the remission rate of UP and prevents proximal extension of disease is unknown. METHODS: This is a retrospective study on 116 outpatients with UP who had been treated with one of the following regimens: (1) MMX mesalazine 1.2 g/die plus mesalazine suppositories for 8 ± 2 weeks and, subsequently, MMX mesalazine 1...
January 16, 2018: Digestive Diseases
https://www.readbyqxmd.com/read/29332096/higher-thrombin-antithrombin-iii-complex-levels-may-indicate-severe-acute-pancreatitis
#16
Sami Fidan, Murat Erkut, Arif Mansur Cosar, Yasar Yogun, Asım Örem, Mehmet Sönmez, Mehmet Arslan
AIM: Coagulation disorders may develop in association with severe acute pancreatitis (AP). Plasma thrombin-antithrombin III complex (TAT) levels are one of the principal markers of coagulation disorder. The purpose of this study was to evaluate TAT and other hemostatic parameters in patients with AP and to examine whether or not these parameters indicate the severity of AP. METHOD: Forty-six patients with AP (14 severe, 32 non-severe) and a 30-member healthy control group were recruited...
January 12, 2018: Digestive Diseases
https://www.readbyqxmd.com/read/29316565/transjugular-intrahepatic-portosystemic-shunt-in-patients-with-portal-hypertension-patency-depends-on-coverage-and-interventionalist-s-experience
#17
Matthias Buechter, Paul Manka, Guido Gerken, Ali Canbay, Sandra Blomeyer, Axel Wetter, Jens Altenbernd, Alisan Kahraman, Jens M Theysohn
BACKGROUND AND AIMS: Transjugular intrahepatic portosystemic shunt (TIPS) is the treatment of choice in decompensated portal hypertension. TIPS revision due to thrombosis or stenosis increases morbidity and mortality. Our aim was to investigate patient- and procedure-associated risk factors for TIPS-revision. PATIENTS AND METHODS: We retrospectively evaluated 189 patients who underwent the TIPS procedure. Only patients who required TIPS revision within 1 year (Group I, 34 patients) and patients who did not require re-intervention within the first year (Group II [control group], 54 patients) were included...
January 9, 2018: Digestive Diseases
https://www.readbyqxmd.com/read/29275413/fatty-acids-as-useful-serological-markers-for-crohn-s-disease
#18
Zensho Ito, Kan Uchiyama, Shunichi Odahara, Shinichiro Takami, Keisuke Saito, Hiroko Kobayashi, Shigeo Koido, Takahiro Kubota, Toshifumi Ohkusa, Masayuki Saruta
BACKGROUND: We have previously reported that patients with Crohn's disease (CD) have a very specific erythrocyte membrane phospholipid fatty acid profile. The findings of this study suggest that the activities of enzymes involved in the metabolism of linoleic acid (LA), that is, delta-6 desaturase, are higher in CD patients than in healthy individuals. METHODS: We evaluated the utilities of various fatty acid compositions of the plasma (p-) as new serological markers for CD compared to those of erythrocyte membranes (e-)...
December 22, 2017: Digestive Diseases
https://www.readbyqxmd.com/read/29258097/clinical-significance-of-o-6-methylguanine-dna-methyltransferase-promoter-methylation-in-patients-with-esophageal-carcinoma-a-systematic-meta-analysis
#19
Yan Zhang, Ti Tong
BACKGROUND: The correlation between O-6-methylguanine-DNA-methyltransferase (MGMT) promoter methylation and esophageal cancer remains controversial. This study was conducted to evaluate the clinical effect of MGMT promoter methylation on esophageal carcinoma patients. METHODS: A literature search was conducted in the PubMed, EMBASE, EBSCO, and Cochrane Library databases. The overall OR and corresponding 95% CI were calculated using the random-effects model. RESULTS: Finally, 17 eligible studies were identified in this meta-analysis; these studies included a total of 1,368 patients with esophageal carcinoma and 1,489 with nonmalignant controls...
December 20, 2017: Digestive Diseases
https://www.readbyqxmd.com/read/29207381/alicaforsen-an-antisense-inhibitor-of-intercellular-adhesion-molecule-1-in-the-treatment-for-left-sided-ulcerative-colitis-and-ulcerative-proctitis
#20
Thomas Greuter, Stephan R Vavricka, Luc Biedermann, Julia Pilz, Jan Borovicka, Frank Seibold, Bernhard Sauter, Gerhard Rogler
BACKGROUND: Data on the efficacy of intercellular adhesion molecule-1 antisense oligonucleotide alicaforsen in ulcerative colitis (UC) is inconsistent. METHODS: All patients, who had received at least one dose of alicaforsen, were analyzed retrospectively. Alicaforsen's efficacy was assessed in patients treated for left-sided UC and proctitis by comparing clinical and (if applicable) endoscopic disease activity before/after treatment. RESULTS: Twelve patients were treated for left-sided UC or proctitis...
December 5, 2017: Digestive Diseases
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