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Journal of Clinical Biochemistry and Nutrition

Yumi Inoh, Kenji Kanoshima, Kanji Ohkuma, Akiko Fuyuki, Shiori Uchiyama, Hidenori Ohkubo, Takuma Higurashi, Hiroshi Iida, Takashi Nonaka, Koji Fujita, Akihiko Kusakabe, Masahiko Inamori, Kazumasa Hiroishi, Hajime Nagase, Atushi Nakajima, Taro Takahara
Although chronic constipation is common, colonic functional evaluating tests are uncommon. This study examines whether chronic constipation and gastrointestinal symptoms are correlated with the lateral diameter of the colon measured from MRI images. We included chronic constipation patients in a prospective, cross-sectional study using MRI at three centers. We divided 3D MRI colorectal images into 6 segments using with specified sequences and selected the maximum luminal diameter from each segment. We used the GSRS questionnaire to evaluate gastrointestinal symptoms...
May 2018: Journal of Clinical Biochemistry and Nutrition
Ryo Katsumata, Akiko Shiotani, Takahisa Murao, Manabu Ishii, Minoru Fujita, Hiroshi Matsumoto, Ken Haruma
The gastrointestinal symptoms of irritable bowel syndrome are strongly related to impaired quality of life (QOL), especially in diarrhea-predominant. The gene polymorphisms associated with serotonin, or 5-hydroxytryptamine, alter gastrointestinal symptoms and mental status. We aimed to evaluate the effects of gene polymorphisms on gastrointestinal symptoms, psychological conditions, and QOL, and compare these between patients with diarrhea-predominant irritable bowel syndrome ( n  = 62) and healthy controls ( n  = 64)...
May 2018: Journal of Clinical Biochemistry and Nutrition
Kyoichi Adachi, Tomoko Mishiro, Takashi Toda, Naomi Kano, Harumi Fujihara, Yuko Mishima, Atsuko Konishi, Mariko Mochida, Kazuko Takahashi, Yoshikazu Kinoshita
The purpose was to clarify the effects of Helicobacter pylori ( H. pylori ) eradication on the changes in serum lipid levels by comparing subjects with and without continuous H. pylori infection. The study subjects were 774 individuals (males 536, females 238, mean age 52.6 years) who visited between April 2013 and March 2016 for annual medical checkups. Serum total cholesterol, high-density lipoprotein cholesterol (HDLC), low-density lipoprotein cholesterol (LDLC), and triglyceride levels, and LDLC/HDLC ratio were compared between the subjects with and without H...
May 2018: Journal of Clinical Biochemistry and Nutrition
Masae Sakuma, Ayaka Suzuki, Minako Kikuchi, Hidekazu Arai
The objective was to evaluate the effect of replacing milk with soymilk or calcium-fortified soymilk as a part of a meal on postprandial serum phosphorus levels. This study had a randomized crossover design. Ten healthy subjects were enrolled and consumed three test meals that contained either milk, soymilk, or calcium-fortified soymilk containing the same amount of calcium as milk. Blood samples were collected at 0, 30, 60, 120, 240 and 360 min and urine samples were collected from 0 to 360 min after consuming the test meal...
May 2018: Journal of Clinical Biochemistry and Nutrition
Toru Yoshikawa, Asako Zempo-Miyaki, Hiroshi Kumagai, Kanae Myoenzono, Rina So, Takehiko Tsujimoto, Kiyoji Tanaka, Seiji Maeda
Pulse pressure amplification (i.e., the ratio of peripheral to central pulse pressure) is a strong predictor of cardiovascular events. Circulating free fatty acid, which is a major cause of insulin resistance, has been reported to favorably be associated with pulse pressure amplification in the arm (from the aorta to brachial artery). We hypothesized that this paradoxical relationship depended on an evaluating site of pulse pressure amplification and investigated whether serum free fatty acid level is related to pulse pressure amplification in the arm or trunk (from the aorta to femoral artery) in overweight/obese men...
May 2018: Journal of Clinical Biochemistry and Nutrition
Keisei Kosaki, Atsuko Kamijo-Ikemori, Takeshi Sugaya, Koichiro Tanahashi, Nobuhiko Akazawa, Chihiro Hibi, Takashi Nakamura, Takayo Murase, Kenjiro Kimura, Yugo Shibagaki, Seiji Maeda
The aim of present study was to investigate the association between plasma xanthine oxidoreductase activity, which has gained attention as a novel preventive target of cardiovascular disease, and various physiological parameters and was to determine the effects of habitual exercise on plasma xanthine oxidoreductase activity in middle-aged and older women. In the cross-sectional study, we investigated the association between plasma xanthine oxidoreductase activity and various physiological parameters in 94 middle-aged and older women...
May 2018: Journal of Clinical Biochemistry and Nutrition
Takafumi Osaka, Yoshitaka Hashimoto, Masahide Hamaguchi, Takao Kojima, Akihiro Obora, Michiaki Fukui
Recent cross-sectional and randomized controlled studies of small sample sizes revealed that regular exercise is effective for improving nonalcoholic fatty liver disease. However, there has been no large-scale longitudinal study addressing the effect of regular exercise on remission of nonalcoholic fatty liver disease. Thus, we investigated the impact of exercise on the natural history of nonalcoholic fatty liver disease. We analyzed 1,010 (860 men and 150 women) Japanese participants who received health checkups repeatedly over 10 years by a historical cohort study and were diagnosed with nonalcoholic fatty liver disease at baseline...
May 2018: Journal of Clinical Biochemistry and Nutrition
Yun-Shan Li, Yuko Ootsuyama, Yuya Kawasaki, Yasuo Morimoto, Toshiaki Higashi, Kazuaki Kawai
Nanoparticles are widely used as useful industrial materials. Therefore, their possible adverse health effects must be appraised. We assessed and compared the oxidative DNA damage caused by four different nanoparticles (TiO2 , NiO, ZnO and CeO2 ). The effects of the administration methods, intratracheal instillation and inhalation, were also evaluated. Rats were subjected to intratracheal instillations or 4 weeks of inhalation exposure to the nanoparticles, and the 8-hydroxydeoxyguanosine (8-OHdG) levels in the lung were analyzed by an HPLC-EC detector method...
May 2018: Journal of Clinical Biochemistry and Nutrition
Amani A Harb, Yasser K Bustanji, Shtaywy S Abdalla
Hypercholesterolemia is a major risk factor for cardiovascular diseases. This study investigated the cholesterol-lowering potential of β-caryophyllene in a rat model. Hypercholesterolemia was induced by feeding male Wistar rats a high cholesterol and fat diet for 2 weeks. This was followed by oral administration of β-caryophyllene to hypercholesterolemic rats at 30, 100 and 300 mg/kg b.w. for 4 weeks. A dose of 30 mg/kg of β-caryophyllene significantly lowered serum total cholesterol, low density lipoprotein and the atherogenic index and significantly increased high density lipoprotein level...
May 2018: Journal of Clinical Biochemistry and Nutrition
Yoshimasa Hirata, Takatoshi Nakagawa, Kazumasa Moriwaki, Eiko Koubayashi, Kazuki Kakimoto, Toshihisa Takeuchi, Takuya Inoue, Kazuhide Higuchi, Michio Asahi
Colon cancer prevalence is high worldwide. O -GlcNAcylation has been associated with tumor growth in various tissues, including the colon; however, its link to carcinogenesis is not fully understood. We investigated the association of O -GlcNAcylation with colon carcinogenesis using a 1,2-dimethylhydrazine/dextran sodium sulfate-induced colon carcinogenesis model in wild type and O -GlcNAc transferase-transgenic ( Ogt -Tg) mice. The incidence of colon cancer was significantly lower in Ogt -Tg than in wild type mice...
May 2018: Journal of Clinical Biochemistry and Nutrition
Yoji Kato, Naoko Suga
There are many chemically reactive compounds, including quinone, in living systems and also food. Even after the ingestion of food polyphenols, quinones derived from catechol moieties could form endogenously in the body. Dopaquinone, dopamine quinone, estrogen-derived quinones, tryptamine-4,5-dione, and ubiquinone are examples of an endogenous quinone. These indicate that quinone is ubiquitously formed or present in living systems and food. Quinones can induce a variety of hazardous effects and also could have beneficial physiological effects...
May 2018: Journal of Clinical Biochemistry and Nutrition
Masayo Shamoto-Nagai, Shinsuke Hisaka, Makoto Naoi, Wakako Maruyama
Recently, toxic α-synuclein oligomer, which can mediate cell-to-cell propagation is suggested to cause sporadic Parkinson disease. α-Synuclein interacts with membrane lipids especially polyunsaturated fatty acids to stabilize its three-dementional structure. Peroxidation of polyunsaturated fatty acids may reduce their affinity to α-synuclein and peroxidation byproducts might modify α-synuclein. 4-Hydroxy-2-nonenal derived from n -6 polyunsaturated fatty acids was reported to modify α-synuclein to produce a toxic oligomer...
May 2018: Journal of Clinical Biochemistry and Nutrition
Masahiro Hayashi, Takashi Ishibashi, Takashi Maoka
This study was conducted to investigate the effect of dietary supplement containing astaxanthin-rich extract derived from Paracoccus carotinifaciens (astaxanthin supplement) on cognitive function of subjects aged 45-64 years. Cognitive functions of 28 subjects orally administered 8 mg astaxanthin/day of astaxanthin supplement for 8 weeks (astaxanthin group) and 26 subjects given a placebo (placebo group) were compared by word memory test, verbal fluency test, and Stroop test. The astaxanthin group experienced significantly larger increase in blood astaxanthin level than the placebo group...
March 2018: Journal of Clinical Biochemistry and Nutrition
Aya Umeno, Toshiki Fukui, Yoshiko Hashimoto, Masatoshi Kataoka, Yoshihisa Hagihara, Hidenori Nagai, Masanori Horie, Mototada Shichiri, Kohzoh Yoshino, Yasukazu Yoshida
We previously reported that type 2 diabetes risk, early impaired glucose tolerance and insulin resistance can be predicted by measuring the fasting levels of certain biomarkers. Here we validated these findings in randomly recruited healthy volunteers ( n  = 101) based on biomarker expression as well as various non-invasive indices. Weight, body mass index, waist circumference and visceral fat differed between individuals with impaired fasting glucose and/or impaired glucose tolerance, and normal subjects...
March 2018: Journal of Clinical Biochemistry and Nutrition
Suk Pyo Shin, Yoon Mi Choi, Won Hee Kim, Sung Pyo Hong, Jong-Min Park, Joohee Kim, Oran Kwon, Eun Hyun Lee, Ki Baik Hahm
The exact pathogenesis of diarrhea-dominant irritable bowel syndrome (IBS) is not known, but the abnormal microbiota of the gastrointestinal tract is considered to be one of the important contributing factors as in other gastrointestinal diseases such as inflammatory bowel disease, antibiotic-associated diarrhea, and colorectal cancer as well as systemic diseases. Though diverse trials of probiotics had been continued in the treatment of diarrhea-IBS, only a few proved by randomized clinical trial. To prove the efficacy of Lactobacillus gasseri BNR17 isolated from breast milk in patients with diarrhea-IBS, prospective, randomized, placebo controlled clinical trial was done including health related-quality of life analysis, colon transit time, and the changes of fecal microbiota...
March 2018: Journal of Clinical Biochemistry and Nutrition
Munetaka Iguchi, Kazuki Kakimoto, Takanori Kuramoto, Kei Nakazawa, Minori Kubota, Yuki Hirata, Kaori Fujiwara, Satoshi Harada, Taisuke Sakanaka, Kazuhiro Ota, Shoko Edogawa, Yuichi Kojima, Sadaharu Nouda, Toshihiko Okada, Ken Kawakami, Toshihisa Takeuchi, Takuya Inoue, Kazuhide Higuchi
Low-dose aspirin, which is widely used to reduce the risk of cardio- and cerebrovascular thrombosis, often induces gastroenteropathy by increasing the permeability of the mucosa. However, therapeutic strategies for patients with low-dose aspirin-induced small intestinal injury have not been determined. We evaluated the preventative effect of egualen sodium hydrate, a gastro-protective agent that suppresses indomethacin-induced small-intestinal damage in rats, against small-intestinal mucosal damage induced by low-dose aspirin in healthy adult male volunteers...
March 2018: Journal of Clinical Biochemistry and Nutrition
Hiromi Kawamura, Sarasa Tanaka, Yuri Ota, Sumire Endo, Mariko Tani, Midori Ishitani, Motoyoshi Sakaue, Mikiko Ito
Phosphorus management through dietetic therapy is vital for the prevention of cardiovascular disease in chronic kidney disease patients. There are two main sources of phosphorus in the diet, organic phosphorus from protein and inorganic phosphorus from food additives. The adverse effects of high phosphorus intake on vascular-endothelium function have been reported; however, the differences in the effects of organic phosphorus versus inorganic phosphorus are not clear. In this study, we examined an acute effect of these high phosphorus meals intake on vascular-endothelium function...
March 2018: Journal of Clinical Biochemistry and Nutrition
Wataru Aoi, Takashi Maoka, Ryo Abe, Mayuko Fujishita, Kumi Tominaga
Astaxanthin, a natural antioxidant, exists in non-esterified and esterified forms. Although it is known that astaxanthin can improve exercise endurance and cause metabolic improvement in skeletal muscle, the effects of the two different forms are unclear. We investigated the effects of the different forms of astaxanthin on endurance in mice. Eight-week-old ICR mice were divided into four groups: control; astaxanthin extracted from Haematococcus pluvialis in an esterified form; astaxanthin extracted from Phaffia rhodozyma in a non-esterified form; and astaxanthin synthesized chemically in a non-esterified form...
March 2018: Journal of Clinical Biochemistry and Nutrition
Ayumi Yoshimoto, Takashi Uebanso, Mutsumi Nakahashi, Takaaki Shimohata, Kazuaki Mawatari, Akira Takahashi
Several environmental factors during the prenatal period transgenerationally affect the health of newborns in later life. Because low-dose antibiotics have been used for promoting the growth of crops and livestock in agriculture, humans may have ingested residual antibiotics for several decades. However, the effect of prenatal administration of low-dose antibiotics on newborns' health in later life is unclear. In the present study, we found that prenatal treatment of murine mothers with low-dose antibiotics increased the abundance of bacteria of the phylum Firmicutes and the genera Clostridium IV and XIVa in feces from pups...
March 2018: Journal of Clinical Biochemistry and Nutrition
Ming Jin, Ming-Hua Shen, Mei-Hua Jin, Ai-Hua Jin, Xue-Zhe Yin, Ji-Shu Quan
The present study was carried out to investigate the hypoglycemic effect of soy isoflavones from hypocotyl in GK diabetic rats. A single administration and long-term administration tests were conducted in GK diabetic rats to test the hypoglycemic effect of soy isoflavones. At the end of long-term administration trial, blood protein, cholesterol, triglyceride, glycosylated serum protein, C-reactive protein, insulin, aminotransferase, lipid peroxide, interleukin-6, tumor necrosis factor-α were estimated. Inhibition of soy isoflavones against α-amylase and α-glucosidase, as well as on glucose uptake into brush border membrane vesicles or Caco-2 cells were determined in vitro ...
March 2018: Journal of Clinical Biochemistry and Nutrition
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