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Journal of Clinical Biochemistry and Nutrition

Tadayoshi Okimoto, Kazuhiro Mizukami, Ryo Ogawa, Kazuhisa Okamoto, Mitsutaka Shuto, Kensuke Fukuda, Masaaki Kodama, Kazunari Murakami
The aim of this study was to assess the efficacy of esomeprazole-based triple therapy compared with rabeprazole-based triple therapy according to CYP2C19 genotype and clarithromycin susceptibility status for first-line eradication therapy of Helicobacter pylori (H. pylori) in Japan. We enrolled 219 H. pylori-infected patients, and randomly allocated patients to the EAC group (esomeprazole 20 mg, clarithromycin 200 mg, amoxicillin 750 mg for one week, with all drugs given twice daily) or RAC group (rabeprazole 10 mg, clarithromycin 200 mg, amoxicillin 750 mg for one week, with all drugs given twice daily)...
September 2016: Journal of Clinical Biochemistry and Nutrition
Kyoichi Adachi, Tomoko Mishiro, Shino Tanaka, Yoshikazu Kinoshita
The purpose is to elucidate factors related to negative results of anti-H. pylori antibody test in cases with gastric mucosal atrophy. A total of 859 individuals without past history of eradication therapy for H. pylori (545 males, 314 females; mean age 52.4 years) who underwent an upper GI endoscopy examination and serological test were enrolled as subjects. Serological testing was performed using SphereLight H. pylori antibody J(®), and endoscopic findings of gastric mucosal atrophy by the classification of Kimura and Takemoto and post-eradication findings were analyzed...
September 2016: Journal of Clinical Biochemistry and Nutrition
Hyun Yoon, Dae Jung Jeon, Chang Eun Park, Hye Sook You, Ae Eun Moon
The purpose of this study is to look at these relationships in non-diabetic Korean adults. This study was based on data from the KNHANES V-1, which is representative of the population of Korea. A total of 5,492 participants (≥20 years in age) without type 1 or type 2 diabetes, assessed for serum 25-hydroxyvitamin D [25(OH)D], fasting blood glucose and insulin, as well as anthropometric variables, were included in the analyses. The key study results were as follows: First, vitamin D status [vitamin D deficient, 25(OH)D <25 nM; vitamin D insufficient, 25(OH)D ≥25, <50 nM; vitamin D sufficient, 25(OH)D ≥50 nM] was inversely associated with homeostasis model assessment of insulin resistance (HOMA-IR) and beta cell function (HOMA-B) in model 2 (adjusted for age and gender) and 3 (further adjusted for smoking, alcohol drinking, regular exercise, systolic and diastolic blood pressure, waist circumference, and body mass index)...
September 2016: Journal of Clinical Biochemistry and Nutrition
Xiao-Xing Chi, Tao Zhang, Dong-Jie Zhang, Wei Yu, Qiu-Ying Wang, Jing-Long Zhen
In this study, we examined the association between soy isoflavones and lipid profiles, apolipoprotein levels in patients with type 2 diabetes in China. The study population was composed of 120 cases (80 women with type 2 diabetes and 40 healthy women). Objects in treatment group received isoflavones 435 mg/day for 2 months, then lipid profiles were analyzed by the colorimetry method and apolipoprotein levels were determined by immune turbidimetric method. And all the indexes were determined after oral glucose tolerance test...
September 2016: Journal of Clinical Biochemistry and Nutrition
Juntaro Matsuzaki, Hidekazu Suzuki, Tatsuhiro Masaoka, Kentaro Tanaka, Hideki Mori, Takanori Kanai
Functional gastrointestinal disorders (FGIDs), including functional dyspepsia (FD), are common chronic disorders even in the younger population. Physical activity is advocated for patients with FGIDs, although the evidence is insufficient. We investigated the association between the intensity of regular exercise and gastric emptying to determine the effect of physical activity on dyspeptic symptoms. Thirty healthy individuals were selected and divided into three groups (low, moderate, and high) using the index of total exercise intensity in a week...
September 2016: Journal of Clinical Biochemistry and Nutrition
Yumi Takemura, Masaya Sasaki, Kenichi Goto, Azusa Takaoka, Akiko Ohi, Mika Kurihara, Naoko Nakanishi, Yasutaka Nakano, Jun Hanaoka
This study aimed to investigate the energy metabolism of patients with lung cancer and the relationship between energy metabolism and proinflammatory cytokines. Twenty-eight patients with lung cancer and 18 healthy controls were enrolled in this study. The nutritional status upon admission was analyzed using nutritional screening tools and laboratory tests. The resting energy expenditure and respiratory quotient were measured using indirect calorimetry, and the predicted resting energy expenditure was calculated using the Harris-Benedict equation...
September 2016: Journal of Clinical Biochemistry and Nutrition
Zeyu Lv, Yuting Wang, Ting Yang, Xue Zhan, Zhongyue Li, Huajian Hu, Tingyu Li, Jie Chen
To investigate whether gut microbiota is associated with vitamin A nutritional levels in children with persistent diarrhea, a total of 59 pediatric patients with persistent diarrhea aged 1-12 months were selected from the Department of Gastroenterology at the Children's Hospital of Chongqing Medical University, China. Subjects were hospitalized and divided into VA-deficient (n = 30) and VA-normal (n = 29) groups according to their venous serum retinol levels. Fecal samples from all 59 subjects were collected immediately after admission and analyzed by Illumina MiSeq for 16S rRNA genes to characterize the overall microbiota of the samples...
September 2016: Journal of Clinical Biochemistry and Nutrition
Hiroko Inoue, Atsuhiro Kishimoto, Ryoko Ushikoshi-Nakayama, Ayaka Hasaka, Ayako Takahashi, Koufuchi Ryo, Takashi Muramatsu, Fumio Ide, Kenji Mishima, Ichiro Saito
Resveratrol is a natural polyphenol produced by plants in response to environmental stress. This compound has been shown to have pharmacological effects against a wide range of diseases including neurological, hepatic, cardiovascular and autoimmune conditions. The non-obese diabetic (NOD) mouse, in which loss of lacrimal and salivary gland function occurs, has been studied as an animal model for Sjögren's syndrome. In this study, we confirmed that administration of resveratrol results in increased secretion of saliva in NOD mice...
September 2016: Journal of Clinical Biochemistry and Nutrition
Chihiro Kamezaki, Ami Nakashima, Asako Yamada, Sachiko Uenishi, Hiroshi Ishibashi, Natsumi Shibuya, Susumu Hama, Shinzo Hosoi, Eiji Yamashita, Kentaro Kogure
Astaxanthin and vitamin E are both effective antioxidants that are frequently used in cosmetics, as food additives, and in to prevent oxidative damage. A combination of astaxanthin and vitamin E would be expected to show an additive anntioxidative effect. In this study, liposomes co-encapsulating astaxanthin and the vitamin E derivatives α-tocopherol (α-T) or tocotrienols (T3) were prepared, and the antioxidative activity of these liposomes toward singlet oxygen and hydroxyl radical was evaluated in vitro...
September 2016: Journal of Clinical Biochemistry and Nutrition
Mika Takeshima, Ikuko Miyazaki, Shinki Murakami, Taizo Kita, Masato Asanuma
l-Theanine (γ-glutamylethylamide), a component of green tea, is considered to have regulatory and neuroprotective roles in the brain. The present study was designed to determine the effect of l-theanine on excess dopamine-induced neurotoxicity in both cell culture and animal experiments. The primary cultured mesencephalic neurons or co-cultures of mesencephalic neurons and striatal astrocytes were pretreated with l-theanine for 72 h, and then treated with excess dopamine for further 24 h. The cell viability of dopamine neurons and levels of glutathione were evaluated...
September 2016: Journal of Clinical Biochemistry and Nutrition
Li Su, Hongli Du, Xin Dong, Xiuhua Zhang, Ziyang Lou
Raf-1 kinase inhibitory protein (RKIP) is a critical molecule for cellular responses to stimuli. In this study, we investigated whether RKIP is responsible for neural cell apoptosis induced by oxygen-glucose deprivation (OGD) and explored the role of NF-κB and ERK pathways regulated by RKIP under OGD stimuli. RKIP was overexpressed or knocked down using lentivirus in PC12 cells, which were then challenged by OGD. RKIP overexpression significantly increased the cell viability of OGD cells, and attenuated apoptosis, cell cycle arrest, and reactive oxygen species generation...
September 2016: Journal of Clinical Biochemistry and Nutrition
Manatsu Kuraji, Tomonori Matsuno, Tazuko Satoh
Oral dryness, a serious problem for the aging Japanese society, is induced by aging-related hyposalivation and causes dysphagia, dysgeusia, inadaptation of dentures, and growth of oral Candida albicans. Oxidative stress clearly plays a role in decreasing saliva secretion and treatment with antioxidants such astaxanthin supplements may be beneficial. Therefore, we evaluated the effects of astaxanthin on the oral saliva secretory function of aging mice. The saliva flow increased in astaxanthin-treated mice 72 weeks after administration while that of the control decreased by half...
September 2016: Journal of Clinical Biochemistry and Nutrition
(no author information available yet)
[This corrects the article DOI: 10.3164/jcbn.15-90.].
July 2016: Journal of Clinical Biochemistry and Nutrition
Yoshihide Kimura, Takeshi Kamiya, Kyouji Senoo, Kenji Tsuchida, Atsuyuki Hirano, Hisayo Kojima, Hiroaki Yamashita, Yoshihiro Yamakawa, Nobuhiro Nishigaki, Tomonori Ozeki, Masatsugu Endo, Kazuhisa Nakanishi, Motoki Sando, Yusuke Inagaki, Michiko Shikano, Tsutomu Mizoshita, Eiji Kubota, Satoshi Tanida, Hiromi Kataoka, Kohei Katsumi, Takashi Joh
Some patients with gastroesophageal reflux disease experience persistent reflux symptoms despite proton pump inhibitor therapy. These symptoms reduce their health-related quality of life. Our aims were to evaluate the relationship between proton pump inhibitor efficacy and health-related quality of life and to evaluate predictive factors affecting treatment response in Japanese patients. Using the gastroesophageal reflux disease questionnaire, 145 gastroesophageal reflux disease patients undergoing proton pump inhibitor therapy were evaluated and classified as responders or partial-responders...
July 2016: Journal of Clinical Biochemistry and Nutrition
Akira Andoh, Atsushi Nishida, Kenichiro Takahashi, Osamu Inatomi, Hirotsugu Imaeda, Shigeki Bamba, Katsuyuki Kito, Mitsushige Sugimoto, Toshio Kobayashi
Altered gut microbial ecology contributes to the development of metabolic diseases including obesity. In this study, we performed 16S rRNA sequence analysis of the gut microbiota profiles of obese and lean Japanese populations. The V3-V4 hypervariable regions of 16S rRNA of fecal samples from 10 obese and 10 lean volunteers were sequenced using the Illumina MiSeq(TM)II system. The average body mass index of the obese and lean group were 38.1 and 16.6 kg/m(2), respectively (p<0.01). The Shannon diversity index was significantly higher in the lean group than in the obese group (p<0...
July 2016: Journal of Clinical Biochemistry and Nutrition
Yuting Wang, Yuan Gao, Quanbo Liu, Xue Zhan, Zhongyue Li, Huajian Hu, Tingyu Li, Jie Chen
To investigate the effect of vitamin A and Zn supplementation on vitamin A status, haemoglobin level and defecation of children with persistent diarrhea, a total of 160 paediatric patients were randomly assigned to one of four intervention groups: daily supplementation of 1,500 IU VA for 14 days; daily Zn supplementation for 14 days; daily supplementation with both VA and Zn for 14 days; no supplementation. One hundred twenty-seven children with persistent diarrhea finished intervention (33 were lost to follow-up)...
July 2016: Journal of Clinical Biochemistry and Nutrition
Noriko Nakajima, Karina Kozu, Shun Kobayashi, Ryu Nishiyama, Rie Okubo, Yuichi Akai, Mitsuhiko Moriyama, Noriko Kinukawa
Overexpression of IGF-1R has been demonstrated in gastrointestinal cancers, and its expression is reported as the result of the loss of tumor suppressors. IL-16 is involved in the pathophysiological process of chronic inflammatory diseases. The aim of this study is to determine the changes in the expression of IGF-1R in intestinal metaplasia (IM) and gastric cancer (GC) as well as the effect of Helicobacter pylori (H. pylori) and IL-16 on cell proliferation and IGF-1R expression in gastric cells. AGS cells were incubated with combinations of IL-16 and H...
July 2016: Journal of Clinical Biochemistry and Nutrition
Susumu Fujii, Megumi Hara, Sayuri Nonaka, Shinichiro Ishikawa, Yosuke Aoki, Keizo Anzai, Shigeki Morita, Kazuma Fujimoto, Masaaki Mawatari
This study aimed to evaluate causative factors for prolonged hospitalization based on hospitalization status, type of hospital ward, and comorbidities, specifically diabetes mellitus and infectious diseases, in 20,876 patients hospitalized in Saga University Hospital from April 1, 2012, to February 28, 2015. Prolonged hospitalization was defined as hospital days exceeding period 3 in the diagnosis procedure combination system. Among all factors, causative (risk) factors for prolonged hospitalization were evaluated by multiple logistic regression analysis...
July 2016: Journal of Clinical Biochemistry and Nutrition
Takeshi Otsuki, Kazuhiro Shimizu, Asako Zempo-Miyaki, Seiji Maeda
Decreases in saliva secretion compromise food mastication and swallowing, reduce mucosal immune function, and increase the risk for oral diseases like dental caries. Chlorella is a green alga that contains a variety of nutrients including amino acids, vitamins, and minerals. In our previous study, Chlorella-derived multicomponent supplementation did not affect salivary flow rates in healthy young individuals, but Chlorella-derived supplementation attenuated a decrease in saliva secretion that was observed during a kendo training camp...
July 2016: Journal of Clinical Biochemistry and Nutrition
Kuo-Ping Shen, Chi-Long Hao, Hsueh-Wei Yen, Chun-Yen Chen, Jia-Hao Chen, Fu-Chih Chen, Hui-Li Lin
Pre-germinated brown rice (PGBR) can ameliorate hyperlipidemia, but the action mechanism is not clear. We focus the mechanisms of PGBR prevented hyperlipidemia. Six-week-old mice were divided into: standard-regular diet (SRD), high-fat diet (HFD) and HFD with PGBR (HFD + PGBR) groups for 16 weeks. The HFD group has higher concentrations of TG, TC, HDL and Non-HDL in the blood, and a higher atherosclerosis index (AI). The TG levels in the liver, and TG, bile acid levels in the feces were enhanced; and the total adipocytokines level in adipose tissue was reduced...
July 2016: Journal of Clinical Biochemistry and Nutrition
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