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Journal of Clinical Biochemistry and Nutrition

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https://www.readbyqxmd.com/read/30087548/comparison-of-the-early-effects-of-vonoprazan-lansoprazole-and-famotidine-on-intragastric-ph-a-three-way-crossover-study
#1
Kanji Ohkuma, Hiroshi Iida, Yumi Inoh, Kenji Kanoshima, Hidenori Ohkubo, Takashi Nonaka, Koji Fujita, Akihiko Kusakabe, Masahiko Inamori, Atsushi Nakajima
To promote symptom relief from acid-related diseases, a medicine with a rapid-onset effect is ideal. The aim of this study was to investigate the early inhibitory effect on gastric acid secretion after a single oral administration of vonoprazan, which represents a new class of proton pump inhibitors, and to compare this effect with those of lansoprazole and famotidine. Ten Helicobacter pylori ( HP )-negative male subjects participated in this randomized, three-way crossover study. A single oral administration of vonoprazan (20 mg), lansoprazole (30 mg) or famotidine (20 mg) was performed, and the intragastric pH was continuously monitored for 6 h...
July 2018: Journal of Clinical Biochemistry and Nutrition
https://www.readbyqxmd.com/read/30087547/quantitative-imaging-mass-spectroscopy-reveals-roles-of-heme-oxygenase-2-for-protecting-against-transhemispheric-diaschisis-in-the-brain-ischemia
#2
Shinichi Goto, Takayuki Morikawa, Akiko Kubo, Keiyo Takubo, Keiichi Fukuda, Mayumi Kajimura, Makoto Suematsu
Carbon monoxide-generating heme oxygenase-2 is expressed in neurons and plays a crucial role for regulating hypoxic vasodilation through mechanisms unlocking carbon monoxide-dependent inhibition of H2 S-generating cystathionine β-synthase expressed in astrocytes. This study aims to examine whether heme oxygenase-2 plays a protective role in mice against stroke. Focal ischemia was induced by middle cerebral artery occlusion. Regional differences in metabolites among ipsilateral and contralateral hemispheres were analysed by quantitative imaging mass spectrometry equipped with an image-processing platform to optimize comparison of local metabolite contents among different animals...
July 2018: Journal of Clinical Biochemistry and Nutrition
https://www.readbyqxmd.com/read/30087546/incidence-of-aspiration-pneumonia-during-hospitalization-in-japanese-hospitalized-cases-did-not-increase-whereas-concern-factors-were-exacerbated-in-a-time-dependent-manner-analysis-of-diagnosis-procedure-combination-dpc-data
#3
Sayuri Nonaka, Susumu Fujii, Megumi Hara, Shigeki Morita, Eisaburo Sueoka, Koichi Node, Kazuma Fujimoto
This study aimed i) to investigate about items with high relevance for aspiration pneumonia during hospitalization among cases evaluated using Diagnosis Procedure Combination data, and ii) to determine whether the concern factors for aspiration pneumonia during hospitalization were exacerbated with the trend of the time. The Diagnosis Procedure Combination data were gathered from 2010 through to 2015 with 63,390 cases at Saga University Hospital. The occurrence of concern factors of aspiration pneumonia during hospitalization were compared in the two time periods set (2010-2012 and 2013-2015)...
July 2018: Journal of Clinical Biochemistry and Nutrition
https://www.readbyqxmd.com/read/30087545/pirfenidone-suppresses-polarization-to-m2-phenotype-macrophages-and-the-fibrogenic-activity-of-rat-lung-fibroblasts
#4
Michihito Toda, Shinjiro Mizuguchi, Yukiko Minamiyama, Hiroko Yamamoto-Oka, Takanori Aota, Shoji Kubo, Noritoshi Nishiyama, Toshihiko Shibata, Shigekazu Takemura
Pirfenidone is a representative medication to treat interstitial pulmonary fibrosis. Researchers reported pirfenidone (>100 µg/ml) significantly suppressed fibroblast growth in vitro . However, clinically, the maximum concentration of pirfenidone in the blood is approximately 10 µg/ml. We hypothesized there might be an additional mechanism of pirfenidone to fibroblasts indirectly. Macrophages are known to control the activation of fibroblasts via the regulation of inflammatory M1 and suppressive M2 polarization...
July 2018: Journal of Clinical Biochemistry and Nutrition
https://www.readbyqxmd.com/read/30087544/effects-of-vitamin-c-and-e-on-toxic-action-of-alcohol-on-partial-hepatectomy-induced-liver-regeneration-in-rats
#5
Yurika Okamura, Akira Omori, Norihiko Asada, Akifumi Ono
The purpose of this study was to investigate the influence of vitamins C and E on the toxic action of alcohol in rat liver regeneration. Male Sprague-Dawley rats subjected to 70% partial hepatectomy were divided into five groups (Groups 1 to 5). Rats in Groups 2 to 5 were only provided alcohol for drinking. Additionally, vitamin C, vitamin E, and vitamin C in combination with vitamin E were administered to Groups 3, 4, and 5, respectively. Alcohol inhibits liver regeneration, resulting in an increase in free radicals produced by alcohol metabolism and thus causing cellular damage and altering liver function...
July 2018: Journal of Clinical Biochemistry and Nutrition
https://www.readbyqxmd.com/read/30087543/%C3%AE-carotene-prevents-bone-loss-in-hind-limb-unloading-mice
#6
Yu Matsumoto, Yuko Tousen, Yoshiko Ishimi
β-Carotene has been reported to be useful to maintain a positive balance of bone turnover. However, the effects of β-carotene on bone loss remain to be elucidated in mice with hind limb unloading. Therefore, we investigated whether β-carotene prevented bone loss induced by skeletal hind limb unloading in mice. Female 8-week-old ddY mice were divided into six groups ( n  = 6-8 each) and subjected to: (1) normal housing, (2) sham unloading fed a control diet, (3) hind limb unloading fed a control diet, (4) hind limb unloading fed a 0...
July 2018: Journal of Clinical Biochemistry and Nutrition
https://www.readbyqxmd.com/read/30087542/acetic-acid-is-an-oxidative-stressor-in-gastric-cancer-cells
#7
Masahiko Terasaki, Hiromu Ito, Hiromi Kurokawa, Masato Tamura, Susumu Okabe, Hirofumi Matsui, Ichinosuke Hyodo
Acetic acid can cause cellular injury. We previously reported that acetic acid induces cancer cell-selective death in rat gastric cells. However, the mechanism is unclear. Generally, cancer cells are more sensitive to reactive oxygen species than normal cells. Accordingly, in this study, we investigated the involvement of oxidative stress in cancer cell-selective death by acetic acid using normal gastric mucosal cells and cancerous gastric mucosal cells. The cancer cell-selective death was induced at the concentration of 2-5 µM acetic acid...
July 2018: Journal of Clinical Biochemistry and Nutrition
https://www.readbyqxmd.com/read/30087541/a-next-generation-beneficial-microbe-akkermansia-muciniphila
#8
REVIEW
Yuji Naito, Kazuhiko Uchiyama, Tomohisa Takagi
There have been many reports on the roles of intestinal flora and intestinal environment in health promotion and disease prevention. Beneficial bacteria such as Bifidobacterium and lactic acid-producing bacteria have been shown to improve the intestinal environment, and yield a good effect on metabolism, immunity and nerve response. In this review, in addition to these beneficial bacteria, we introduced Akkermansia muciniphila as a next-generation beneficial microbe. Several reports indicate that Akkermansia muciniphila affects glucose metabolism, lipid metabolism, and intestinal immunity, and that certain food ingredients such as polyphenols may increase the abundance of Akkermansia muciniphila in the gut...
July 2018: Journal of Clinical Biochemistry and Nutrition
https://www.readbyqxmd.com/read/30087540/microbiome-and-intestinal-ischemia-reperfusion-injury
#9
REVIEW
Yuji Nadatani, Toshio Watanabe, Sunao Shimada, Koji Otani, Tetsuya Tanigawa, Yasuhiro Fujiwara
Intestinal ischemia/reperfusion injury is a severe disease associated with a high mortality. The mechanisms that cause ischemia/reperfusion injury are complex and many factors are involved in the injury formation process; however, the only available treatment is surgical intervention. Recent studies demonstrated that the intestinal microbiome plays a key role in intestinal ischemia/reperfusion injury and there are many factors associated with intestinal bacteria during the formation of the intestinal ischemia/reperfusion injury...
July 2018: Journal of Clinical Biochemistry and Nutrition
https://www.readbyqxmd.com/read/30087539/role-of-nrf2-in-protection-of-the-gastrointestinal-tract-against-oxidative-stress
#10
REVIEW
Akinori Yanaka
The gastrointestinal tract is exposed to a variety of noxious factors, such as Helicobacter pylori , nonsteroidal anti-inflammatory drugs, gastric acid, ischemia-reperfusion, and mental stresses. Theses stressors generate free radicals within gastrointestinal tissues, causing organ injury and functional disturbance. Although the gastrointestinal tract can withstand such oxidative stresses to some extent by enhancing its antioxidant system via nuclear factor erythroid 2-related factor 2-Kelch-like erythroid cell-derived protein with CNC homology-associated protein 1-mediated pathways, acute or chronic exposure to oxidative stress can cause several gastrointestinal tract disorders, such as inflammation, ulcers, cancers, and various functional disturbances...
July 2018: Journal of Clinical Biochemistry and Nutrition
https://www.readbyqxmd.com/read/30087538/function-and-structural-regulation-of-the-carbon-monoxide-co-responsive-membrane-protein-pgrmc1
#11
REVIEW
Yasuaki Kabe, Hiroshi Handa, Makoto Suematsu
Progesterone receptor membrane associated component 1 is a multifunctional heme-binding protein that plays a role in several biological processes such as tumor progression, metabolic regulation, and viability control of nerve cells. Notably, progesterone receptor membrane associated component 1 is highly expressed in various types of cancer cells, and facilitates cancer proliferation and chemoresistance. Recently, progesterone receptor membrane associated component 1 structure has been explored by X-ray crystallographic analysis...
July 2018: Journal of Clinical Biochemistry and Nutrition
https://www.readbyqxmd.com/read/30087537/extracellular-micrornas-and-oxidative-stress-in-liver-injury-a-systematic-mini-review
#12
REVIEW
Juntaro Matsuzaki, Takahiro Ochiya
Recent evidence has suggested that extracellular microRNAs have crucial roles in intercellular communications and are promising as minimally invasive biomarkers for various diseases including cancers. Oxidative stress also plays an essential role in homeostasis and disease development. This systematic review aims to clarify the current evidence on the interaction between oxidative stress and extracellular microRNAs. We identified 32 studies that provided information regarding the association between oxidative stress and extracellular microRNAs: 9 focused on the central nervous system, 11 focused on cardiovascular diseases, and 4 focused on liver injury...
July 2018: Journal of Clinical Biochemistry and Nutrition
https://www.readbyqxmd.com/read/30087536/introduction-to-serial-reviews-oxidative-stress-and-digestive-diseases
#13
REVIEW
Hidekazu Suzuki
No abstract text is available yet for this article.
July 2018: Journal of Clinical Biochemistry and Nutrition
https://www.readbyqxmd.com/read/30087535/redox-related-gaseous-mediators-in-the-gastrointestinal-tract
#14
REVIEW
Yuji Naito, Kazuhiko Uchiyama, Tomohisa Takagi
Redox-related gaseous molecular species in the gastrointestinal tract are derived from the chemical oxidation-reduction reactions, enzymatic reactions, swallowing, and bacterial production. Recent studies have demonstrated the crucial roles of the microbiota and gaseous molecules in the pathogenesis of gastrointestinal inflammatory and functional diseases. Especially in the hypoxic condition of the large intestine, various bacteria produce acetic acid, methane, and hydrogen sulfide using hydrogen molecules generated by the fermentation reaction as an energy source...
July 2018: Journal of Clinical Biochemistry and Nutrition
https://www.readbyqxmd.com/read/29892169/assessment-of-colonic-contents-in-patients-with-chronic-constipation-using-mri
#15
Yumi Inoh, Kenji Kanoshima, Kanji Ohkuma, Akiko Fuyuki, Shiori Uchiyama, Hidenori Ohkubo, Takuma Higurashi, Hiroshi Iida, Takashi Nonaka, Koji Fujita, Akihiko Kusakabe, Masahiko Inamori, Kazumasa Hiroishi, Hajime Nagase, Atushi Nakajima, Taro Takahara
Although chronic constipation is common, colonic functional evaluating tests are uncommon. This study examines whether chronic constipation and gastrointestinal symptoms are correlated with the lateral diameter of the colon measured from MRI images. We included chronic constipation patients in a prospective, cross-sectional study using MRI at three centers. We divided 3D MRI colorectal images into 6 segments using with specified sequences and selected the maximum luminal diameter from each segment. We used the GSRS questionnaire to evaluate gastrointestinal symptoms...
May 2018: Journal of Clinical Biochemistry and Nutrition
https://www.readbyqxmd.com/read/29892168/the-tph1-rs211105-gene-polymorphism-affects-abdominal-symptoms-and-quality-of-life-of-diarrhea-predominant-irritable-bowel-syndrome
#16
Ryo Katsumata, Akiko Shiotani, Takahisa Murao, Manabu Ishii, Minoru Fujita, Hiroshi Matsumoto, Ken Haruma
The gastrointestinal symptoms of irritable bowel syndrome are strongly related to impaired quality of life (QOL), especially in diarrhea-predominant. The gene polymorphisms associated with serotonin, or 5-hydroxytryptamine, alter gastrointestinal symptoms and mental status. We aimed to evaluate the effects of gene polymorphisms on gastrointestinal symptoms, psychological conditions, and QOL, and compare these between patients with diarrhea-predominant irritable bowel syndrome ( n  = 62) and healthy controls ( n  = 64)...
May 2018: Journal of Clinical Biochemistry and Nutrition
https://www.readbyqxmd.com/read/29892167/effects-of-helicobacter-pylori-eradication-on-serum-lipid-levels
#17
Kyoichi Adachi, Tomoko Mishiro, Takashi Toda, Naomi Kano, Harumi Fujihara, Yuko Mishima, Atsuko Konishi, Mariko Mochida, Kazuko Takahashi, Yoshikazu Kinoshita
The purpose was to clarify the effects of Helicobacter pylori ( H. pylori ) eradication on the changes in serum lipid levels by comparing subjects with and without continuous H. pylori infection. The study subjects were 774 individuals (males 536, females 238, mean age 52.6 years) who visited between April 2013 and March 2016 for annual medical checkups. Serum total cholesterol, high-density lipoprotein cholesterol (HDLC), low-density lipoprotein cholesterol (LDLC), and triglyceride levels, and LDLC/HDLC ratio were compared between the subjects with and without H...
May 2018: Journal of Clinical Biochemistry and Nutrition
https://www.readbyqxmd.com/read/29892166/soymilk-intake-has-desirable-effects-on-phosphorus-and-calcium-metabolism
#18
Masae Sakuma, Ayaka Suzuki, Minako Kikuchi, Hidekazu Arai
The objective was to evaluate the effect of replacing milk with soymilk or calcium-fortified soymilk as a part of a meal on postprandial serum phosphorus levels. This study had a randomized crossover design. Ten healthy subjects were enrolled and consumed three test meals that contained either milk, soymilk, or calcium-fortified soymilk containing the same amount of calcium as milk. Blood samples were collected at 0, 30, 60, 120, 240 and 360 min and urine samples were collected from 0 to 360 min after consuming the test meal...
May 2018: Journal of Clinical Biochemistry and Nutrition
https://www.readbyqxmd.com/read/29892165/relationships-between-serum-free-fatty-acid-and-pulse-pressure-amplification-in-overweight-obese-men-insights-from-exercise-training-and-dietary-modification
#19
Toru Yoshikawa, Asako Zempo-Miyaki, Hiroshi Kumagai, Kanae Myoenzono, Rina So, Takehiko Tsujimoto, Kiyoji Tanaka, Seiji Maeda
Pulse pressure amplification (i.e., the ratio of peripheral to central pulse pressure) is a strong predictor of cardiovascular events. Circulating free fatty acid, which is a major cause of insulin resistance, has been reported to favorably be associated with pulse pressure amplification in the arm (from the aorta to brachial artery). We hypothesized that this paradoxical relationship depended on an evaluating site of pulse pressure amplification and investigated whether serum free fatty acid level is related to pulse pressure amplification in the arm or trunk (from the aorta to femoral artery) in overweight/obese men...
May 2018: Journal of Clinical Biochemistry and Nutrition
https://www.readbyqxmd.com/read/29892164/habitual-exercise-decreases-plasma-xanthine-oxidoreductase-activity-in-middle-aged-and-older-women
#20
Keisei Kosaki, Atsuko Kamijo-Ikemori, Takeshi Sugaya, Koichiro Tanahashi, Nobuhiko Akazawa, Chihiro Hibi, Takashi Nakamura, Takayo Murase, Kenjiro Kimura, Yugo Shibagaki, Seiji Maeda
The aim of present study was to investigate the association between plasma xanthine oxidoreductase activity, which has gained attention as a novel preventive target of cardiovascular disease, and various physiological parameters and was to determine the effects of habitual exercise on plasma xanthine oxidoreductase activity in middle-aged and older women. In the cross-sectional study, we investigated the association between plasma xanthine oxidoreductase activity and various physiological parameters in 94 middle-aged and older women...
May 2018: Journal of Clinical Biochemistry and Nutrition
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