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Journal of Clinical Biochemistry and Nutrition

Daisuke Chinda, Tadashi Shimoyama, Kuniaki Miyazawa, Tetsu Arai, Shiro Hayamizu, Miyuki Yanagimachi, Toshiaki Tsukamoto, Kazuki Akitaya, Tetsuya Tatsuta, Shogo Kawaguchi, Hidezumi Kikuchi, Hiroto Hiraga, Manabu Sawaya, Hirotake Sakuraba, Tatsuya Mikami, Shinsaku Fukuda
The aim of this study was to assess the perioperative invasiveness of endoscopic submucosal dissection for colorectal cancer quantitatively by using energy metabolism. In fifty-three patients who underwent endoscopic submucosal dissection for colorectal cancer, resting energy expenditure using an indirect calorimeter, body weight and basal energy expenditure using the Harris-Benedict equation before and after endoscopic submucosal dissection. Resting energy expenditure/body weight and resting energy expenditure/basal energy expenditure were 19...
September 2018: Journal of Clinical Biochemistry and Nutrition
Keisuke Nakai, Jiro Watari, Katsuyuki Tozawa, Akio Tamura, Ken Hara, Takahisa Yamasaki, Takashi Kondo, Tomoaki Kono, Toshihiko Tomita, Yoshio Ohda, Tadayuki Oshima, Hirokazu Fukui, Jun Sakurai, Yongmin Kim, Yuji Hayakawa, Takashi Fujisawa, Takeshi Morimoto, Hiroto Miwa
To investigate sex differences in the associations among metabolic syndrome, obesity, adipose tissue-related biomarkers, and colorectal adenomatous polyps, a cross-sectional, multicenter study was conducted on 489 consecutive individuals who underwent their first colonoscopy at 3 hospitals. Plasma concentrations of adiponectin and leptin, as well as homeostatic model assessment of insulin resistance were also evaluated. The presence and number of adenomatous polyps, including advanced adenoma, were higher in men than in women...
September 2018: Journal of Clinical Biochemistry and Nutrition
Shiro Nakamura, Toshio Watanabe, Sunao Shimada, Yuji Nadatani, Koji Otani, Tetsuya Tanigawa, Takako Miyazaki, Masaki Iimuro, Yasuhiro Fujiwara
A large proportion of patients demonstrating obscure gastrointestinal bleeding (OGIB) are antithrombotic users and need to undergo small bowel capsule endoscopy (SBCE). We examined the effect of discontinuation of antithrombotics on the diagnostic yield of SBCE. Additionally, we assessed predictive factors associated with positive SBCE findings. Our study included 130 patients using antithrombotics who underwent SBCE for overt OGIB. The primary endpoint was the difference in the rate of positive SBCE findings between patients who continued and those who discontinued antithrombotics...
September 2018: Journal of Clinical Biochemistry and Nutrition
Ingrid Žitňanová, Pavel Šiarnik, Matej Füllöp, Stanislav Oravec, Adela Penesová, Zdenka Ďuračková, Eva Vaská, Peter Turčáni, Branislav Kollár
The aim of our study was to examine gender differences of LDL- and HDL-cholesterol subfractions in patients after the acute ischemic stroke with focus on small LDL and HDL subfractions, and their association with oxidative stress markers. In addition, we have monitored the 7-day effect of cholesterol-lowering drugs administered to patients after the acute ischemic stroke, on these subfractions. Eighty two stroke patients and 81 age matched controls were included in this study. Blood was collected from patients within 24 h after the stroke (group A) and re-examined at the 7-day follow-up (group B)...
September 2018: Journal of Clinical Biochemistry and Nutrition
Junko Yamaguchi, Midori Nagase, Yorihiro Yamamoto, Atsushi Sakurai, Airi Kubo, Hikaru Mitsuhashi, Masaru Matsuoka, Shingo Ihara, Kosaku Kinoshita
Sepsis remains one of the leading causes of death in intensive care units. The early phase of sepsis is characterized by a massive formation of reactive oxygen and nitrogen species such as superoxide and nitric oxide. However, few comprehensive studies on plasma antioxidants have been reported. Increased oxidative stress was confirmed in sepsis patients ( n  = 18) at the time of hospitalization by a significant decrease in plasma ascorbic acid and a significant increase in the percentage of oxidized form of coenzyme Q10 in total coenzyme Q10 compared to age-matched healthy controls ( n  = 62)...
September 2018: Journal of Clinical Biochemistry and Nutrition
Midori Nagase, Yorihiro Yamamoto, Nozomi Matsumoto, Yasumichi Arai, Nobuyoshi Hirose
Aging populations are expanding worldwide, and the increasing requirement for nursing care has become a serious problem. Furthermore, successful aging is one of the highest priorities for individuals and societies. Centenarians are an informative cohort to study and inflammation has been found to be a key factor in predicting cognition and physical capabilities. Inflammation scores have been determined based on the levels of cytokines and C-reactive protein, however, serum antioxidants and lipid profiles have not been carefully examined...
September 2018: Journal of Clinical Biochemistry and Nutrition
Shoji Yamada, Masaki Kimura, Yoshimasa Saito, Hidetsugu Saito
The exact mechanisms of hepatocellular carcinoma development in non-alcoholic steatohepatitis remain unclear. In this study, we used a new class of high-fat diet, which could induce hepatocellular carcinoma development without the use of general chemical carcinogens or knockout mice. We investigated the correlation between hepatocellular carcinoma and oxidative stress/anti-oxidant effects after depletion of the gut microbiota by treatment with antibiotics. Mice fed with the steatohepatitis-inducing high-fat diet (STHD-01) for 41 weeks developed hepatocellular carcinoma...
September 2018: Journal of Clinical Biochemistry and Nutrition
Keiichi Koshinaka, Rie Ando, Akiko Sato
Dietary intervention for preventing postprandial increases in glucose level by replacing high-glycemic index (GI) carbohydrates with lower-GI carbohydrate has been proposed as a strategy for treating insulin-resistant metabolic disorders such as type II diabetes. In this study, we examined the effect of short-term replacement of starch with a low-GI disaccharide, isomaltulose, on insulin action in skeletal muscle. Male Wistar rats were fed isomaltulose for 12 h during their dark cycle. In isolated epitrochlearis muscle, insulin-induced glucose uptake was greater in tissue from rats treated with isomaltulose than from those treated with starch...
September 2018: Journal of Clinical Biochemistry and Nutrition
Noriyuki Kitagawa, Masahide Hamaguchi, Saori Majima, Takuya Fukuda, Toshihiro Kimura, Yoshitaka Hashimoto, Muhei Tanaka, Masahiro Yamazaki, Naoto Nakamura, Michiaki Fukui
Dipeptidyl peptidase-4 (DPP-4) is a critical molecule for the metabolism of incretins. In addition, DPP-4 is known as CD26, the receptor of T cells, and plays important role in activation of T cells. Recently, DPP-4 inhibitors (DPP4i) are reported to have several immunologic effects beyond glycemic control. DPP4i seem to have anti-inflammatory effects in patients with type 2 diabetes. This might be direct effects on T cells. However, the close mechanism is not clear. To evaluate the possibility, we performed ex vivo assays by using primarily human CD4+ T cells (CD4) and CD8+ T cells (CD8)...
September 2018: Journal of Clinical Biochemistry and Nutrition
Takanari Nakano, Ikuo Inoue, Yasuhiro Takenaka, Yuichi Ikegami, Norihiro Kotani, Akira Shimada, Mitsuhiko Noda, Takayuki Murakoshi
Plant sterols are used as food additives to reduce intestinal cholesterol absorption. They also increase fecal neutral sterol (FNS) excretion irrespective of the absorption inhibition. Intestine-mediated reverse cholesterol transport, or trans-intestinal cholesterol efflux (TICE), provides the major part of the increase of FNS excretion. However, it is unknown whether plant sterols stimulate TICE or not. We have shown previously that TICE can be evaluated by brush border membrane (BBM)-to-lumen cholesterol efflux...
September 2018: Journal of Clinical Biochemistry and Nutrition
Yukihiro Ogawa, Emiko Sekine-Suzuki, Megumi Ueno, Ikuo Nakanishi, Ken-Ichiro Matsumoto
The generation of localized hydroxyl radical (• OH) in aqueous samples by low linear energy transfer irradiation was investigated. Several concentrations of 5,5-dimethyl-1-pyrroline- N -oxid solution (from 0.5 to 1,680 mmol/L) were prepared and irradiated with an identical dose of X-ray or γ-ray. The density of • OH generation in aqueous solution was evaluated by the electron paramagnetic resonance spin-trapping technique using 5,5-dimethyl-1-pyrroline- N -oxid as an electron paramagnetic resonance spin-trapping agent...
September 2018: Journal of Clinical Biochemistry and Nutrition
Yuji Matsui, Hideo Iwahashi
This study examines oxidizability in individual aqueous solutions of oleic acid, linoleic acid, α-linolenic acid, γ-linolenic acid and arachidonic acid, and in their mixtures. We used electron spin resonance (ESR), high performance liquid chromatography-electron spin resonance (HPLC-ESR) and high performance liquid chromatography-electron spin resonance-mass spectrometries (HPLC-ESR-MS). We detected 4-carboxybutyl radical derived from γ-linolenic acid, ethyl and 7-carboxyheptyl radicals derived from α-linolenic acid, and pentyl and 7-carboxyheptyl radicals derived from linoleic acid...
September 2018: Journal of Clinical Biochemistry and Nutrition
Sayaka Iida, Yorihiro Yamamoto, Chisato Susa, Kana Tsukui, Akio Fujisawa
Although uric acid is known to react with many reactive oxygen species, its specific oxidation products have not been fully characterized. We now report that 5- N -carboxyimino-6- N -chloroaminopyrimidine-2,4(3 H )-dione (CCPD) is a hypochlorite (ClO- )-specific oxidation product of uric acid. The yield of CCPD was 40-70% regardless of the rate of mixing of ClO- with uric acid. A previously reported product, allantoin (AL), was a minor product. Its yield (0-20%) decreased with decreasing rate of mixing of ClO- with uric acid, indicating that allantoin is less important in vivo ...
September 2018: Journal of Clinical Biochemistry and Nutrition
Kanji Ohkuma, Hiroshi Iida, Yumi Inoh, Kenji Kanoshima, Hidenori Ohkubo, Takashi Nonaka, Koji Fujita, Akihiko Kusakabe, Masahiko Inamori, Atsushi Nakajima
To promote symptom relief from acid-related diseases, a medicine with a rapid-onset effect is ideal. The aim of this study was to investigate the early inhibitory effect on gastric acid secretion after a single oral administration of vonoprazan, which represents a new class of proton pump inhibitors, and to compare this effect with those of lansoprazole and famotidine. Ten Helicobacter pylori ( HP )-negative male subjects participated in this randomized, three-way crossover study. A single oral administration of vonoprazan (20 mg), lansoprazole (30 mg) or famotidine (20 mg) was performed, and the intragastric pH was continuously monitored for 6 h...
July 2018: Journal of Clinical Biochemistry and Nutrition
Shinichi Goto, Takayuki Morikawa, Akiko Kubo, Keiyo Takubo, Keiichi Fukuda, Mayumi Kajimura, Makoto Suematsu
Carbon monoxide-generating heme oxygenase-2 is expressed in neurons and plays a crucial role for regulating hypoxic vasodilation through mechanisms unlocking carbon monoxide-dependent inhibition of H2 S-generating cystathionine β-synthase expressed in astrocytes. This study aims to examine whether heme oxygenase-2 plays a protective role in mice against stroke. Focal ischemia was induced by middle cerebral artery occlusion. Regional differences in metabolites among ipsilateral and contralateral hemispheres were analysed by quantitative imaging mass spectrometry equipped with an image-processing platform to optimize comparison of local metabolite contents among different animals...
July 2018: Journal of Clinical Biochemistry and Nutrition
Sayuri Nonaka, Susumu Fujii, Megumi Hara, Shigeki Morita, Eisaburo Sueoka, Koichi Node, Kazuma Fujimoto
This study aimed i) to investigate about items with high relevance for aspiration pneumonia during hospitalization among cases evaluated using Diagnosis Procedure Combination data, and ii) to determine whether the concern factors for aspiration pneumonia during hospitalization were exacerbated with the trend of the time. The Diagnosis Procedure Combination data were gathered from 2010 through to 2015 with 63,390 cases at Saga University Hospital. The occurrence of concern factors of aspiration pneumonia during hospitalization were compared in the two time periods set (2010-2012 and 2013-2015)...
July 2018: Journal of Clinical Biochemistry and Nutrition
Michihito Toda, Shinjiro Mizuguchi, Yukiko Minamiyama, Hiroko Yamamoto-Oka, Takanori Aota, Shoji Kubo, Noritoshi Nishiyama, Toshihiko Shibata, Shigekazu Takemura
Pirfenidone is a representative medication to treat interstitial pulmonary fibrosis. Researchers reported pirfenidone (>100 µg/ml) significantly suppressed fibroblast growth in vitro . However, clinically, the maximum concentration of pirfenidone in the blood is approximately 10 µg/ml. We hypothesized there might be an additional mechanism of pirfenidone to fibroblasts indirectly. Macrophages are known to control the activation of fibroblasts via the regulation of inflammatory M1 and suppressive M2 polarization...
July 2018: Journal of Clinical Biochemistry and Nutrition
Yurika Okamura, Akira Omori, Norihiko Asada, Akifumi Ono
The purpose of this study was to investigate the influence of vitamins C and E on the toxic action of alcohol in rat liver regeneration. Male Sprague-Dawley rats subjected to 70% partial hepatectomy were divided into five groups (Groups 1 to 5). Rats in Groups 2 to 5 were only provided alcohol for drinking. Additionally, vitamin C, vitamin E, and vitamin C in combination with vitamin E were administered to Groups 3, 4, and 5, respectively. Alcohol inhibits liver regeneration, resulting in an increase in free radicals produced by alcohol metabolism and thus causing cellular damage and altering liver function...
July 2018: Journal of Clinical Biochemistry and Nutrition
Yu Matsumoto, Yuko Tousen, Yoshiko Ishimi
β-Carotene has been reported to be useful to maintain a positive balance of bone turnover. However, the effects of β-carotene on bone loss remain to be elucidated in mice with hind limb unloading. Therefore, we investigated whether β-carotene prevented bone loss induced by skeletal hind limb unloading in mice. Female 8-week-old ddY mice were divided into six groups ( n  = 6-8 each) and subjected to: (1) normal housing, (2) sham unloading fed a control diet, (3) hind limb unloading fed a control diet, (4) hind limb unloading fed a 0...
July 2018: Journal of Clinical Biochemistry and Nutrition
Masahiko Terasaki, Hiromu Ito, Hiromi Kurokawa, Masato Tamura, Susumu Okabe, Hirofumi Matsui, Ichinosuke Hyodo
Acetic acid can cause cellular injury. We previously reported that acetic acid induces cancer cell-selective death in rat gastric cells. However, the mechanism is unclear. Generally, cancer cells are more sensitive to reactive oxygen species than normal cells. Accordingly, in this study, we investigated the involvement of oxidative stress in cancer cell-selective death by acetic acid using normal gastric mucosal cells and cancerous gastric mucosal cells. The cancer cell-selective death was induced at the concentration of 2-5 µM acetic acid...
July 2018: Journal of Clinical Biochemistry and Nutrition
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