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Pediatric Hematology and Oncology

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https://www.readbyqxmd.com/read/29870301/impact-of-zinc-on-sexual-maturation-of-female-sickle-cell-anemia-sca-children-in-enugu-southeast-nigeria
#1
Vivian Ozoemena Onukwuli, Josephat Chinawa, Christopher Bismarck Eke, Ada Rosemary Nwokocha, Ifeoma Josephine Emodi, Anthony Nnaemeka Ikefuna
Adolescence is an important developmental period of childhood. Good health and adequate nutrition consisting major food constituents and trace elements like zinc are fundamental for optimal sexual maturation. To determine the relationship between zinc levels and pattern of breast and pubic hair development, as well as menarcheal age of female SCA children aged 6-18 years and their matched controls with hemoglobin genotype AA. Cross sectional, case-control study. Information on biodata, age at menarche, medical and drug history as well as 24-hour dietary recall was documented using interviewer administered questionnaire...
June 5, 2018: Pediatric Hematology and Oncology
https://www.readbyqxmd.com/read/29737912/an-overview-of-disparities-in-childhood-cancer-report-on-the-inaugural-symposium-on-childhood-cancer-health-disparities-houston-texas-2016
#2
Michael E Scheurer, Philip J Lupo, Joachim Schüz, Logan G Spector, Joseph L Wiemels, Richard Aplenc, M Monica Gramatges, Joshua D Schiffman, Maria S Pombo-de-Oliveira, Jun J Yang, Julia E Heck, Catherine Metayer, Manuela A Orjuela-Grimm, Kira Bona, Paula Aristizabal, Mary T Austin, Karen R Rabin, Heidi V Russell, David G Poplack
The Inaugural Symposium on Childhood Cancer Health Disparities was held in Houston, Texas, on November 2, 2016. The symposium was attended by 109 scientists and clinicians from diverse disciplinary backgrounds with interests in pediatric cancer disparities and focused on reviewing our current knowledge of disparities in cancer risk and outcomes for select childhood cancers. Following a full day of topical sessions, everyone participated in a brainstorming session to develop a working strategy for the continued expansion of research in this area...
May 8, 2018: Pediatric Hematology and Oncology
https://www.readbyqxmd.com/read/29737901/chromogranin-a-and-neuron-specific-enolase-in-neuroblastoma-correlation-to-stage-and-prognostic-factors
#3
Kleopatra Georgantzi, Erik G Sköldenberg, Mats Stridsberg, Per Kogner, Åke Jakobson, Eva Tiensuu Janson, Rolf H B Christofferson
Chromogranin A (CgA) and neuron specific enolase (NSE) are important markers in adult neuroendocrine tumors (NET). Neuroblastoma (NB) has certain neuroendocrine properties. The aim of this study was to correlate blood concentrations of CgA, chromogranin B (CgB), and NSE to prognostic factors and outcome in children with NB. Blood samples from 92 patients with NB, 12 patients with benign ganglioneuroma (GN), 21 patients with non-NB solid tumors, 10 patients with acute leukemias, and 69 healthy children, were analyzed...
May 8, 2018: Pediatric Hematology and Oncology
https://www.readbyqxmd.com/read/29648917/successful-treatment-of-systemic-ebv-positive-t-cell-lymphoma-of-childhood-using-the-smile-regimen
#4
Masanori Yoshida, Tomoo Osumi, Ken-Ichi Imadome, Daisuke Tomizawa, Motohiro Kato, Noritaka Miyazawa, Reiko Ito, Atsuko Nakazawa, Kimikazu Matsumoto
No abstract text is available yet for this article.
April 12, 2018: Pediatric Hematology and Oncology
https://www.readbyqxmd.com/read/29648910/usefulness-of-positron-emission-tomography-ct-for-diagnosis-of-primary-bone-marrow-lymphoma-in-children
#5
Kyoko Moritani, Naoko Nakano, Sachiko Yonezawa, Fumihiro Ochi, Hisamichi Tauchi, Minenori Eguchi-Ishimae, Mariko Eguchi, Eiichi Ishii, Kozo Nagai
Primary bone marrow lymphoma (PBML) is hard to diagnose in children, due to the difficult identification of malignant cells in bone marrow. The first case, a 5-year-old boy, showed knee swelling with an intermittent fever. The second case, a 12-year-old girl, showed fever of unknown origin without lymphadenopathy or hepatosplenomegaly. In both cases, the diagnosis was not confirmed despite the repeated bone marrow aspirations. Finally, bone marrow aspiration and biopsy at the positive site by positron emission tomography (PET)-CT contributed to definitive diagnosis of PBML...
April 12, 2018: Pediatric Hematology and Oncology
https://www.readbyqxmd.com/read/29648903/cardiotoxicity-of-anthracycline-ant-treatment-in-children-with-malignant-tumors
#6
Huimin Hu, Weiling Zhang, Dongsheng Huang, Qingmiao Yang, Jing Li, Yanan Gao
OBJECTIVE: To investigate the cardiotoxicity indexes in children with malignant tumors after the administration of anthracycline (ANT) chemotherapy. MATERIALS AND METHODS: Data from 131 children with malignant tumors who were treated using ANT chemotherapy at our hospital from January 2011 to December 2015 were collected to analyze the serologic indexes (such as N-terminal pro-brain natriuretic peptide [NT-proBNP] and isoenzyme of creatine kinase [CK-MB]) and changes in corrected QT interval(QT-c) and left ventricular ejection fraction (LVEF) before and after treatment with different ANT cumulative doses...
April 12, 2018: Pediatric Hematology and Oncology
https://www.readbyqxmd.com/read/29652561/treatment-of-metastatic-hepatocellular-carcinoma-in-pediatric-patients-two-case-reports
#7
Helen Pearson, A S Knisely, Maesha Deheragoda, Stergios Zacharoulis, Fernando Carceller
No abstract text is available yet for this article.
February 2018: Pediatric Hematology and Oncology
https://www.readbyqxmd.com/read/29652554/impact-of-attention-on-social-functioning-in-pediatric-medulloblastoma-survivors
#8
Alice Ann Holland, Beth Colaluca, Laurie Bailey, Peter L Stavinoha
BACKGROUND: Parent-reported attention problems have been associated with social functioning in a broad sample of pediatric cancer survivors. OBJECTIVE: The present study focused on a more homogeneous sample (pediatric medulloblastoma survivors), with the novel inclusion of self-reported attention ratings. PARTICIPANTS/METHODS: Thirty-three pediatric medulloblastoma survivors, ages 7-18 years, completed a brief IQ measure and self-report of attentional and social functioning...
February 2018: Pediatric Hematology and Oncology
https://www.readbyqxmd.com/read/29652549/prolonged-granulocyte-colony-stimulating-factor-use-in-glycogen-storage-disease-type-1b-associated-with-acute-myeloid-leukemia-and-with-shortened-telomere-length
#9
Amanda M Li, Santhosh Thyagu, Dawn Maze, Richard Schreiber, Sandra Sirrs, Sylvia Stockler-Ipsiroglu, Heather Sutherland, Suzanne Vercauteren, Kirk R Schultz
Glycogen storage disease (GSD) type 1 is a rare autosomal recessive inherited condition. The 1b subtype comprises the minority of cases, with an estimated prevalence of 1 in 500,000 children. Patients with glycogen storage disease type 1b are often treated with granulocyte colony stimulating factor (G-CSF) for prolonged periods to improve symptoms of inflammatory bowel disease (IBD) and in the face of severe neutropenia to decrease risk of infection. Long-term G-CSF treatment may result in an increased risk of myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML) possibly due to increased marrow stress resulting in telomere shortening...
February 2018: Pediatric Hematology and Oncology
https://www.readbyqxmd.com/read/29648904/inflammatory-cytokines-and-depression-in-children-with-cancer-a-review-of-the-literature
#10
Gaya Narendran, Lianne Tomfohr, Fiona Schulte
Compared to the general pediatric population, pediatric cancer patients are at increased risk of experiencing depressive symptoms during and after their treatment. Clinically, there exist few resources to guide health care professionals in the care of children with cancer who report depressive symptomatology. Pediatric cancer patients experience unique inflammatory changes secondary to their disease and accompanying treatments. It has been reported that inflammatory changes in the context of illness are related to cytokine dysregulation which in turn may influence the expression of depressive symptoms...
February 2018: Pediatric Hematology and Oncology
https://www.readbyqxmd.com/read/29565756/treatment-challenges-and-outcomes-for-pediatric-intracranial-ependymoma-at-a-single-institution-in-iran
#11
Maryam Tashvighi, Azim Mehrvar, Amir Abbas Hedayati Asl, Narjes Mehrvar, Raheb Ghorbani, Ali Naderi, Mardawig Alebouyeh, Erfan Sattary, Naghmeh Niktoreh Mofrad, Ibrahim Qaddoumi, Mohammad Faranoush
BACKGROUND: The scarcity of information on pediatric ependymoma in Iran motivated this study. Our main objectives were to determine outcomes, identify clinical management challenges at a nongovernment hospital in Iran, and devise guidelines for improving care. PROCEDURE: A retrospective chart review was performed for pediatric patients with ependymoma who were younger than 15 years and treated at MPCTRC between 2007 and 2015. Records included patient demographics, treatment regimens used, duration of follow-up, and outcomes...
February 2018: Pediatric Hematology and Oncology
https://www.readbyqxmd.com/read/29528261/influence-of-il15-gene-variations-on-the-clinical-features-treatment-response-and-risk-of-developing-childhood-acute-lymphoblastic-leukemia-in-latvian-population
#12
Dmitrijs Rots, Madara Kreile, Sergejs Nikulshin, Zhanna Kovalova, Linda Gailite
Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy. Modern treatment protocols allow achievement of long-term event-free survival rates in up to 85% of cases, although the treatment response varies among different patient groups. It is hypothesized that treatment response is influenced by the IL15 gene variations, although research results are conflicting. To analyze IL15 gene variations influence treatment response, clinical course and the risk of developing ALL we performed a case-control and family-based study...
February 2018: Pediatric Hematology and Oncology
https://www.readbyqxmd.com/read/29528260/prevalence-of-hypertension-determined-by-ambulatory-blood-pressure-monitoring-abpm-and-body-composition-in-long-term-survivors-of-childhood-cancer
#13
Elif Guler, Nilgun Col, Mithat Buyukcelik, Ayse Balat
AIM: In recent years, survival rates of childhood cancers have significantly increased, and occurrence of long-term adverse late effects (eg, insulin resistance, diabetes mellitus, metabolic syndrome, hypertension) has become increasingly important. Early diagnosis of obesity/hypertension in childhood is essential to avoid morbidity in the adulthood. Therefore, this study was aimed to determine the blood pressure (BP) profile by ambulatory BP monitoring (ABPM) method, and prevalence of hypertension, obesity, abdominal obesity among childhood cancer survivors...
February 2018: Pediatric Hematology and Oncology
https://www.readbyqxmd.com/read/29432071/neurocysticercosis-an-unusual-seizure-etiology-in-a-hematopoietic-stem-cell-transplanted-patient
#14
Laura Illade, Blanca Molina Angulo, Ines Solís, Miguel Ángel Diaz, Marta Gonzalez-Vicent
No abstract text is available yet for this article.
February 2018: Pediatric Hematology and Oncology
https://www.readbyqxmd.com/read/29420106/syncytial-variant-of-nodular-sclerosing-hodgkin-lymphoma-in-children-a-prognostic-factor
#15
Noa Granot, Ayelet Ben-Barak, Yael Fisher, Hana Golan, Myriam Weyl Ben-Arush
Nodular sclerosing Hodgkin lymphoma (HL) has an excellent prognosis in children. The syncytial variant (SV) of HL in adults represents a clinic pathologic entity with a worse outcome. We report the clinical features and the course of the disease of three children with refractory HL. The three patients with SV were analyzed in a retrospective multi-institutional study conducted in Israel in 51 children diagnosed with refractory or recurrent HL between 1997 and 2014. All the three children developed multiple recurrences soon after diagnosis...
February 2018: Pediatric Hematology and Oncology
https://www.readbyqxmd.com/read/29388861/poor-performance-status-urban-residence-and-female-sex-predict-inferior-survival-in-pediatric-advanced-stage-mature-b-nhl-in-an-indian-tertiary-care-center
#16
Amol Patel, Meher Chand Sharma, Saumyaranjan Mallick, Manali Patel, Sameer Bakhshi
BACKGROUND: Advanced stage is a known prognostic factor in B-Non-Hodgkin Lymphoma (NHL); however, factors within advanced stage and overall data on pediatric B-NHL from India are lacking. METHODS: This is a retrospective study wherein all consecutive pediatric (≤18 years) patients of advanced stage B-NHL (St. Jude stage 3 and 4) treated at our center from Jan 2003 to June 2016 with BFM-90 protocol were evaluated for outcome and pathology review. RESULTS: Total 140 patients were analyzed with median age 8 years; M:F ratio was 5...
February 2018: Pediatric Hematology and Oncology
https://www.readbyqxmd.com/read/29359982/vitamin-d-deficiency-and-its-relationship-with-cardiac-iron-and-function-in-patients-with-transfusion-dependent-thalassemia-at-chiang-mai-university-hospital
#17
Prapai Dejkhamron, Karn Wejaphikul, Tuanjit Mahatumarat, Suchaya Silvilairat, Pimlak Charoenkwan, Suwit Saekho, Kevalee Unachak
BACKGROUND: Vitamin D deficiency is common in patients with thalassemia. Vitamin D deficiency could be related to cardiac dysfunction. Increased parathyroid hormone (PTH) is also known to be associated with heart failure. OBJECTIVES: To determine the prevalence of Vitamin D deficiency and to explore the impact of Vitamin D deficiency on cardiac iron and function in patients with transfusion-dependent thalassemia. METHOD: A cross-sectional study in patients with Transfusion-dependent thalassemia was conducted...
February 2018: Pediatric Hematology and Oncology
https://www.readbyqxmd.com/read/29337597/hydroxyurea-for-lifelong-transfusion-dependent-%C3%AE-thalassemia-a-meta-analysis
#18
Ali H Algiraigri, Nicola A M Wright, Elizabeth Oddone Paolucci, Aliya Kassam
OBJECTIVE: Chronic blood transfusion remains the most feasible therapeutic option for lifelong transfusion-dependent β-thalassemia (lifelong TDβT). However, it is associated with serious risks and complications. Hydroxyurea (HU), an oral chemotherapeutic drug, is expected to increase hemoglobin levels, thereby minimizing the burden of blood transfusion and its complications. Growing literature over the last twenty years suggests promising results of the use HU in lifelong TDβT; however, its role and safety remain unanswered questions...
November 2017: Pediatric Hematology and Oncology
https://www.readbyqxmd.com/read/29337595/outcome-of-extraocular-retinoblastoma-in-a-resource-limited-center-from-low-middle-income-country
#19
Gitika Pant, Nishant Verma, Archana Kumar, Vishal Pooniya, Sanjiv Kumar Gupta
Retinoblastoma (RB) is the most common ocular malignancy in children, and is managed by multimodal treatment. There is a paucity of data regarding the clinical profile and outcome of children with extraocular retinoblastoma from Low Middle Income Countries (LMIC) including India. Case records of children with newly diagnosed extraocular RB from January 2013 to August 2016 treated at our unit were analysed for clinical profile, treatment, and outcome. Over the 44 month study period, 91 children were diagnosed with RB, out of which 41 had extraocular disease...
November 2017: Pediatric Hematology and Oncology
https://www.readbyqxmd.com/read/29303660/acute-megakaryoblastic-leukemia-excluding-down-syndrome-remains-an-acute-myeloid-subgroup-with-inferior-outcome-in-the-french-elam02-trial
#20
Anne-Charlotte Teyssier, Hélène Lapillonne, Marlene Pasquet, Paola Ballerini, André Baruchel, Stephane Ducassou, Odile Fenneteau, Arnaud Petit, Wendy Cuccuini, Christine Ragu, Claude Preudhomme, Thomas Mercher, Nicolas Sirvent, Guy Leverger
We report the outcome of 27 children with de novo acute megakaryoblastic leukemia (AMKL) (excluding Down syndrome) enrolled in the French multicenter prospective study ELAM02 (2005-2011). There was no difference in gender, initial leukocyte count, CNS involvement, and complete remission rate (88.9%), as compared to other acute myeloid leukemia (AML) subtypes. AMKL patients had a significantly poorer outcome (5-year overall survival 54% [CI 95% 33%-71%] than children with other AML subtypes (5-year overall survival 73% [CI 95% 68%-77%] p = 0...
November 2017: Pediatric Hematology and Oncology
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