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Pediatric Hematology and Oncology

Megan N Perez, Christina M Sharkey, Alayna P Tackett, Alexandria M Delozier, Dana M Bakula, Kaitlyn L Gamwell, Sunnye Mayes, Rene McNall, John M Chaney, Ashley H Clawson, Larry L Mullins
OBJECTIVE: Caregivers of pediatric cancer patients are at risk for posttraumatic stress symptoms (PTSS). Previous literature has identified caregiver illness uncertainty as a predictor of PTSS, yet little is known about the mechanism by which illness uncertainty may affect PTSS. Rumination, or perseverations about the cause and consequences of an event, has been related to posttraumtic stress disorder in other populations. However, limited research of this relationship exists for pediatric cancer caregivers...
November 5, 2018: Pediatric Hematology and Oncology
Christen B Samaan, Monica N Valentin, Megan O'Brien Jamison, Kathleen Ellison, Kalyani S Marathe, Scott A Norton, A Yasmine Kirkorian
Erythema ab igne (EAI) is an asymptomatic dermatosis caused by prolonged exposure to localized heat. Affected areas have net-like hyperpigmentation that may resemble more serious conditions such as livedo racemosa or vasculitis. We report three cases of EAI in pediatric sickle cell disease (SCD) patients who were initially suspected of having a more severe, life-threatening disorder before Dermatology was consulted. Clinicians caring for pediatric SCD patients who regularly use heating pads/devices for pain relief should consider EAI in the differential diagnosis of large areas of net-like hyperpigmentation...
October 25, 2018: Pediatric Hematology and Oncology
Sherifa A Hamed, Eman Fathalla Gad, Tahra Kamel Sherif
AIM: Frequent cyanotic breath holding spells cause fear and severe anxiety to parents. This study aimed to evaluate clinical, laboratory and treatment characteristics of children with cyanotic breath holding spells. METHODS: Included were 180 children (mean age: 1.82 ± 0.53 years) with cyanotic breath holding spells. They were divided into three groups: with iron deficiency, with iron deficiency anemia and without iron deficiency. Blood hemoglobin (HB), ferritin and iron concentrations were measured at baseline and after 3 and 6 months of iron treatment...
October 23, 2018: Pediatric Hematology and Oncology
Nicholas S Whipple, Laura L Marion, David M Dansie, Andrea T Murina, Gail C Megason, Vani Vijayakumar, Betty L Herrington
No abstract text is available yet for this article.
October 22, 2018: Pediatric Hematology and Oncology
Funda Erol Cipe, Mehmet Halil Celiksoy, Biray Erturk, Çiğdem Aydogmus
INTRODUCTION: Severe congenital neutropenia (SCN) includes a group of genetic disorders which cause to arrest of neutrophil maturation. SCN can be associated with heterogenous group of genetic defects in ELANE, GFI1, HAX1, G6PC3, JAGN1, VPS45 or activating mutations in the Wiskott-Aldrich syndrome (WAS) gene. AIM: Here we report a patient who has a HAX1 mutation presented with cyclic manner. CASE REPORT: A 6 year old female patients was admitted with recurrent apthous stomatitis...
October 22, 2018: Pediatric Hematology and Oncology
Salih Güler, Metin Demirkaya, Emin Balkan, İrfan Kırıştıoğlu, Nizamettin Kılıç, Betül Sevinir
INTRODUCTION: The aim of this study is to evaluate late side effects that affect quality of life in children with sacrococcygeal teratoma (SCT). PATIENTS AND METHODS: The patients with SCT were evaluated retrospectively. The data were expressed by percentage and the subgroups were compared statistically. RESULTS: A total of 40 children with SCT were identified with median age 12 days (range: 1 day-14.6 years), 27 of whom were analyzed in this study with urodynamic data available for 24 and anal manometric evaluations for 20...
October 22, 2018: Pediatric Hematology and Oncology
Waltraud Friesenbichler, Wolfgang Krizmanich, Karoly Lakatos, Andishe Attarbaschi, Michael Dworzak, Gabriele Amann, Rhoikos Furtwängler, Norbert Graf, Leo Kager
Although the fate of nephrogenic rests varies, they are known to be precursors of Wilms tumour. Thus, nephrogenic rests require adequate treatment to prevent malignant transformation. We added 13-cis retinoic acid to the standard chemotherapy with vincristine and actinomycin-D in two patients with bilateral nephrogenic rests/nephroblastomatosis. Patient 1 also had a history of Wilms tumour. 46 (patient 1) and 81 (patient 2) months after end of treatment, both patients show stable conditions with no signs of relapse or progressive disease...
September 27, 2018: Pediatric Hematology and Oncology
Meagan R Doyle, J Martin Johnston
Li-Fraumeni syndrome is an autosomal dominant cancer syndrome characterized by pathogenic variants in the TP53 gene on chromosome 17. The most common cancers in Li-Fraumeni kindreds include sarcomas, breast cancer, brain tumors, and adrenocortical carcinoma. We report a 9-month-old male who was diagnosed with an adrenocortical tumor and later found to harbor a novel TP53 c.559 G > C germline variant, resulting in p.Gly187Arg. Family history included early-onset breast cancer in his paternal grandmother and paternal great-grandfather, as well as colon cancer at age 31 in a paternal cousin...
September 21, 2018: Pediatric Hematology and Oncology
Trijn Israels, Dalida Pidini, Eric Borgstein, Simon Bailey, Clara Tump, George Chagaluka, Steve Kamiza, Elizabeth Molyneux
Wilms tumor (WT) has a survival rate above 90% in high income countries. Reported survival rates in sub-Saharan Africa are much lower and long-term outcome is not well known as follow-up is challenging. In Blantyre, Malawi, an adapted WT treatment guideline with preoperative chemotherapy, supportive care, and strategies to enable children and parents to complete treatment was introduced in 2006. Between 2006 and 2011, 73 children with a unilateral WT were treated. Follow-up, including home visits when needed, was done...
September 21, 2018: Pediatric Hematology and Oncology
Amalia Schiavetti, Valeria Pedetti, Giulia Varrasso, Oriana Marrucci, Camilla Celani, Gianmarco Andreoli, Enea Bonci
AIM: Little data is available on long-term renal impairment in survivors from childhood sarcoma. We investigated the prevalence of renal impairment and hypertension after very long-term follow-up in survivors who reached adulthood after treatment for childhood sarcoma. METHODS: A cross-sectional single center study was performed. Outcomes included estimating glomerular filtration rate (eGFR), albuminuria, glycosuria, serum phosphate and magnesium, tubular reabsorption phosphate (TRP), chronic kidney disease (CKD) according to the "Kidney Disease: Improving Global Outcomes" (KDIGO) guidelines and blood pressure (BP)...
September 19, 2018: Pediatric Hematology and Oncology
İhsan Özdemir, Faruk Güçlü Pınarlı, Ferda Alpaslan Pınarlı, F Nur Baran Aksakal, Arzu Okur, Pınar Uyar Göçün, Ceyda Karadeniz
The aim of the study was to investigate the expression and methylation status of seven distinctive genes with tumor suppressing properties in childhood and adolescent lymphomas. A total of 96 patients with Hodgkin Lymphoma (HL, n = 41), Non-Hodgkin Lymphoma (NHL, n = 15), and reactive lymphoid hyperplasia (RLH, n = 40, as controls) are included in the research. The expression status of CDKN2A, SPI1, PRDX2, DLEC1, FOXO1, KLF4 and DAPK1 genes were measured with QPCR method after the RNA isolation from paraffin blocks of tumor tissue and cDNA conversion...
March 2018: Pediatric Hematology and Oncology
Vivian Ozoemena Onukwuli, Josephat Chinawa, Christopher Bismarck Eke, Ada Rosemary Nwokocha, Ifeoma Josephine Emodi, Anthony Nnaemeka Ikefuna
Adolescence is an important developmental period of childhood. Good health and adequate nutrition consisting major food constituents and trace elements like zinc are fundamental for optimal sexual maturation. To determine the relationship between zinc levels and pattern of breast and pubic hair development, as well as menarcheal age of female SCA children aged 6-18 years and their matched controls with hemoglobin genotype AA. Cross sectional, case-control study. Information on biodata, age at menarche, medical and drug history as well as 24-hour dietary recall was documented using interviewer administered questionnaire...
March 2018: Pediatric Hematology and Oncology
Michael E Scheurer, Philip J Lupo, Joachim Schüz, Logan G Spector, Joseph L Wiemels, Richard Aplenc, M Monica Gramatges, Joshua D Schiffman, Maria S Pombo-de-Oliveira, Jun J Yang, Julia E Heck, Catherine Metayer, Manuela A Orjuela-Grimm, Kira Bona, Paula Aristizabal, Mary T Austin, Karen R Rabin, Heidi V Russell, David G Poplack
The Inaugural Symposium on Childhood Cancer Health Disparities was held in Houston, Texas, on November 2, 2016. The symposium was attended by 109 scientists and clinicians from diverse disciplinary backgrounds with interests in pediatric cancer disparities and focused on reviewing our current knowledge of disparities in cancer risk and outcomes for select childhood cancers. Following a full day of topical sessions, everyone participated in a brainstorming session to develop a working strategy for the continued expansion of research in this area...
March 2018: Pediatric Hematology and Oncology
Kleopatra Georgantzi, Erik G Sköldenberg, Mats Stridsberg, Per Kogner, Åke Jakobson, Eva Tiensuu Janson, Rolf H B Christofferson
Chromogranin A (CgA) and neuron specific enolase (NSE) are important markers in adult neuroendocrine tumors (NET). Neuroblastoma (NB) has certain neuroendocrine properties. The aim of this study was to correlate blood concentrations of CgA, chromogranin B (CgB), and NSE to prognostic factors and outcome in children with NB. Blood samples from 92 patients with NB, 12 patients with benign ganglioneuroma (GN), 21 patients with non-NB solid tumors, 10 patients with acute leukemias, and 69 healthy children, were analyzed...
March 2018: Pediatric Hematology and Oncology
Masanori Yoshida, Tomoo Osumi, Ken-Ichi Imadome, Daisuke Tomizawa, Motohiro Kato, Noritaka Miyazawa, Reiko Ito, Atsuko Nakazawa, Kimikazu Matsumoto
No abstract text is available yet for this article.
March 2018: Pediatric Hematology and Oncology
Kyoko Moritani, Naoko Nakano, Sachiko Yonezawa, Fumihiro Ochi, Hisamichi Tauchi, Minenori Eguchi-Ishimae, Mariko Eguchi, Eiichi Ishii, Kozo Nagai
Primary bone marrow lymphoma (PBML) is hard to diagnose in children, due to the difficult identification of malignant cells in bone marrow. The first case, a 5-year-old boy, showed knee swelling with an intermittent fever. The second case, a 12-year-old girl, showed fever of unknown origin without lymphadenopathy or hepatosplenomegaly. In both cases, the diagnosis was not confirmed despite the repeated bone marrow aspirations. Finally, bone marrow aspiration and biopsy at the positive site by positron emission tomography (PET)-CT contributed to definitive diagnosis of PBML...
March 2018: Pediatric Hematology and Oncology
Huimin Hu, Weiling Zhang, Dongsheng Huang, Qingmiao Yang, Jing Li, Yanan Gao
OBJECTIVE: To investigate the cardiotoxicity indexes in children with malignant tumors after the administration of anthracycline (ANT) chemotherapy. MATERIALS AND METHODS: Data from 131 children with malignant tumors who were treated using ANT chemotherapy at our hospital from January 2011 to December 2015 were collected to analyze the serologic indexes (such as N-terminal pro-brain natriuretic peptide [NT-proBNP] and isoenzyme of creatine kinase [CK-MB]) and changes in corrected QT interval(QT-c) and left ventricular ejection fraction (LVEF) before and after treatment with different ANT cumulative doses...
March 2018: Pediatric Hematology and Oncology
Helen Pearson, A S Knisely, Maesha Deheragoda, Stergios Zacharoulis, Fernando Carceller
No abstract text is available yet for this article.
February 2018: Pediatric Hematology and Oncology
Alice Ann Holland, Beth Colaluca, Laurie Bailey, Peter L Stavinoha
BACKGROUND: Parent-reported attention problems have been associated with social functioning in a broad sample of pediatric cancer survivors. OBJECTIVE: The present study focused on a more homogeneous sample (pediatric medulloblastoma survivors), with the novel inclusion of self-reported attention ratings. PARTICIPANTS/METHODS: Thirty-three pediatric medulloblastoma survivors, ages 7-18 years, completed a brief IQ measure and self-report of attentional and social functioning...
February 2018: Pediatric Hematology and Oncology
Amanda M Li, Santhosh Thyagu, Dawn Maze, Richard Schreiber, Sandra Sirrs, Sylvia Stockler-Ipsiroglu, Heather Sutherland, Suzanne Vercauteren, Kirk R Schultz
Glycogen storage disease (GSD) type 1 is a rare autosomal recessive inherited condition. The 1b subtype comprises the minority of cases, with an estimated prevalence of 1 in 500,000 children. Patients with glycogen storage disease type 1b are often treated with granulocyte colony stimulating factor (G-CSF) for prolonged periods to improve symptoms of inflammatory bowel disease (IBD) and in the face of severe neutropenia to decrease risk of infection. Long-term G-CSF treatment may result in an increased risk of myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML) possibly due to increased marrow stress resulting in telomere shortening...
February 2018: Pediatric Hematology and Oncology
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