Dianhui Chen, Feng Mo, Meiling Liu, Lin Liu, Junmin Xing, Wei Xiao, Yumei Gong, Shanni Tang, Zhengrong Tan, Guikuan Liang, Hongyan Xie, Jun Huang, Juan Shen, Xingfei Pan
Although the functions of programmed death-1 (PD-1) on αβ T cells have been extensively reported, a role for PD-1 in regulating γδT cell function is only beginning to emerge. Here, we investigated the phenotypic and functional characteristics of PD-1-expressing γδT cells, and the molecular mechanism was also explored in the Plasmodium yoelii nigeriensis (P. yoelii NSM)-infected mice. Flow cytometry and single-cell RNA sequencing (scRNA-seq) were performed. An inverse agonist of RORα, SR3335, was used to investigate the role of RORα in regulating PD-1+ γδT cells...
January 24, 2024: Immunologic Research