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Immunologic Research

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https://www.readbyqxmd.com/read/29019081/modification-of-nk-cell-subset-repartition-and-functions-in-granulocyte-colony-stimulating-factor-mobilized-leukapheresis-after-expansion-with-il-15
#1
Yu Xiong, Manon Mouginot, Loic Reppel, Chongsheng Qian, Jean-Francois Stoltz, Danièle Bensoussan, Véronique Decot
The ability of natural killer (NK) cells to kill tumor cells without antigen recognition makes them appealing as an adoptive immunotherapy. However, NK cells are not routinely used in the context of leukemic relapse after hematopoietic stem cell transplantation. Patients who experience relapse can be treated with donor lymphocyte infusions (DLI) based on small-cell fractions frozen at the time of transplantation. Since peripheral blood stem cells (PBSCs) are increasingly used as a stem cell source and as a source of cells for DLI, we aimed to evaluate the impact of G-SCF mobilization on NK cell phenotype, subset repartition, and functionality...
October 10, 2017: Immunologic Research
https://www.readbyqxmd.com/read/28983871/human-amylin-induces-cd4-foxp3-regulatory-t-cells-in-the-protection-from-autoimmune-diabetes
#2
Xiao-Xi Zhang, Yong-Chao Qiao, Wan Li, Xia Zou, Yin-Ling Chen, Jian Shen, Qin-Yuan Liao, Qiu-Jin Zhang, Lan He, Hai-Lu Zhao
Autoimmune diabetes is a disorder of immune homeostasis that leads to targeted insulin-secreting islet β cell destruction characterized by insulitis. Human amylin (hA) is an important neuroendocrine hormone co-secreted with insulin by pancreatic β cells. Here, we report hA immune-modulatory action through inducing regulatory T cells. We ex vivo-treated human peripheral blood mononuclear cells (hPBMCs) with hA for 24 h and counted CD4+Foxp3+ regulatory T cells (Treg) using flow cytometry. Diabetic status was monitored and splenic Treg were measured in non-obese diabetic (NOD) male mice...
October 5, 2017: Immunologic Research
https://www.readbyqxmd.com/read/28940167/th2-biased-immune-response-and-agglutinating-antibodies-generation-by-a-chimeric-protein-comprising-ompc-epitope-323-336-of-aeromonas-hydrophila-and-ltb
#3
Mahima Sharma, Pujarini Dash, Pramod K Sahoo, Aparna Dixit
Aeromonas hydrophila is responsible for causing fatal infections in freshwater fishes. Besides chemical/antibiotic treatment and whole-cell vaccine, no subunit vaccine is currently available for A. hydrophila. Outer membrane proteins of gram-negative bacteria have been reported as effective vaccine candidates. Peptide antigens elicit focused immune responses against immunodominant stretches of the antigen. We have attempted to characterize the immunogenicity of linear B-cell epitopes of outer membrane protein (OmpC) of A...
September 22, 2017: Immunologic Research
https://www.readbyqxmd.com/read/28929313/an-anti-propionibacterium-acnes-antibody-shows-heterologous-resistance-to-an-actinobacillus-pleuropneumoniae-infection-independent-of-neutrophils-in-mice
#4
Jian-Fang Liu, Qiu-Yue Ma, Ri-Ning Zhu, Meng-Jun Cheng, Chun-Tong Bao, Jing-Min Gu, Chang-Jiang Sun, Paul Richard Langford, Wen-Yu Han, Lian-Cheng Lei
Porcine contagious pleuropneumonia is a highly fatal respiratory disease that is caused by Actinobacillus pleuropneumoniae (APP) and results in tremendous economic losses for the pig breeding industry worldwide. Previous studies have demonstrated that Propionibacterium acnes (PA) could effectively prevent APP infection in mice and pigs. The humoral immune response played a primary role during this process and anti-PA antibody could mediate macrophages to kill the bacteria. However, the role of neutrophils in this process is currently unknown...
September 20, 2017: Immunologic Research
https://www.readbyqxmd.com/read/28929317/risk-alleles-for-iga-nephropathy-associated-snps-conferred-completely-opposite-effects-to-idiopathic-membranous-nephropathy-in-chinese-han
#5
Xiaosong Qin, Chen Wang, Guanting Lu, Mengle Peng, Guixue Cheng, Hongquan Zhu, Yun Cao, Jianhua Liu, Yuzhong Li, Hong Cai, Funing Yang, Yanhong Liu, Xiaoyu Chen, Liubing Li, Nan Wan, Xiaoting Wen, Shijun Li, Ruili Nie, Dongchun Qin, Yongzhe Li, Yong Liu
The coexistence of immunoglobulin A nephropathy (IgAN) and idiopathic membranous nephropathy (IMN) in a few cases suggested that there could be existed a similar mechanism in pathogenesis of these two types of primary glomerulonephritis. In order to verify this hypothesis, a total of 23 reported IgAN-associated SNPs were genotyped in a cohort of 485 IMN patients and 569 healthy controls with Chinese Han origin. After Cochran-Armitage test for trend analysis, seven IgAN-associated SNPs located in the major histocompatibility complex (MHC) region were found to be significantly associated with the susceptibility of IMN, with rs9275596 as the top one (p = 1...
September 19, 2017: Immunologic Research
https://www.readbyqxmd.com/read/28914425/platelet-factor-4-increases-bone-marrow-b-cell-development-and-differentiation
#6
David J Field, Angela A Aggrey-Amable, Sara K Blick, Sara K Ture, Andrew Johanson, Scott J Cameron, Sukanya Roy, Craig N Morrell
Platelet factor 4 (PF4) is a megakaryocyte-/platelet-derived chemokine with diverse functions as a regulator of vascular and immune biology. PF4 has a central role in vessel injury responses, innate immune cell responses, and T-helper cell differentiation. We have now discovered that PF4 has a direct role in B cell differentiation in the bone marrow. Mice lacking PF4 (PF4(-/-) mice) had fewer developing B cells in the bone marrow beginning after the pre-pro-B cell stage of differentiation. In vitro, PF4 increased the differentiation of hematopoietic progenitors to B cell lineage cells, indicating that PF4 has a direct effect on B cell differentiation...
September 15, 2017: Immunologic Research
https://www.readbyqxmd.com/read/28913776/interactions-of-antisera-to-different-chlamydia-and-chlamydophila-species-with-the-ribosomal-protein-rps27a-correlate-with-impaired-protein-synthesis-in-a-human-choroid-plexus-papilloma-cell-line
#7
Abdullah Almamy, Christian Schwerk, Horst Schroten, Hiroshi Ishikawa, Abdul Rahman Asif, Bernhard Reuss
Chlamydia trachomatis (CT) and the Chlamydophila species (CS) Chlamydophila pneumoniae (CPn), and Chlamydophila psittaci (CPs) are suggested to induce autoantibodies causative of several human autoimmune disorders like rheumatoid arthritis and systemic lupus erythematosus (SLE). The aim of the present study was therefore to identify cellular protein interaction partners with antisera to CT (α-CT) or CS (α-CS) and to identify functional consequences of such interaction in vitro. As detected with a commercial first trimester human prenatal brain multiprotein array (hEXselect, Engine, Germany), the most frequent interaction partner with both α-CT and α-CS was the ribosomal small subunit protein RPS27a...
September 14, 2017: Immunologic Research
https://www.readbyqxmd.com/read/28905195/experimental-evidences-for-mir-30b-as-a-negative-regulator-of-foxo3-upregulated-by-kynurenine
#8
Zhi-Qing Duan, Yan Li, Lu Li
Molecular constituents regulated by the microenvironment components profoundly influence the propensity of cancer metastasis, a key event of estimating therapeutic actions of anticancer drugs. On one hand, kynurenine (Kyn), one of the microenvironment components, plays key roles in the metastasis of cancer cells in vivo; on the other hand, forkhead box O3 (FOXO3) can serve as a therapeutic target of various anticancer drugs. However, the effect of Kyn on FOXO3 is still not clear. The current study demonstrated that the selected dose of Kyn significantly upregulated the FOXO3 protein rather than FOXO3 messenger RNA (mRNA) in the lung cancer 95D cells...
September 13, 2017: Immunologic Research
https://www.readbyqxmd.com/read/28905194/is-there-an-association-between-pemphigus-and-hepatitis-viruses-a-population-based-large-scale-study
#9
Khalaf Kridin, Shira Zelber-Sagi, Doron Comaneshter, Arnon D Cohen
The association between pemphigus and hepatitis viruses has not been investigated sufficiently and remains unclear. Our objective was to assess the association between pemphigus and chronic hepatitis B (HBV) and hepatitis C (HCV) infections using a large-scale real-life computerized database. This study was conducted as a cross-sectional study utilizing the database of Clalit Health Services. The proportion of chronic HBV and HCV infections was compared between patients diagnosed with pemphigus and age-, sex-, and ethnicity-matched controls...
September 13, 2017: Immunologic Research
https://www.readbyqxmd.com/read/28895026/growth-arrest-specific-protein-7-regulates-the-murine-m1-alveolar-macrophage-polarization
#10
Qian Xu, Xiaofan Liu, Xinyuan Wang, Yuanqi Hua, Xiaoying Wang, Junli Chen, Jingyu Li, Yi Wang, Tobias Stoeger, Shanze Chen, Ning Huang
Growth arrest-specific gene 7 (Gas7) is preferentially expressed in terminally differentiated brain cells and plays a crucial role during neuronal development and neurite outgrowth. Apart from that, Gas7 was found to be abundantly expressed in immune cells like murine macrophage without knowing the actual roles in immune reaction. By using the Illumina microarray analysis, we observed a clear induction of Gas7 but no other Gas family members in murine M1-polarized alveolar macrophage, which was further confirmed by RT-qPCR, Western blotting, and immunostaining analysis, suggesting a likelihood that Gas7 may participate in murine alveolar macrophage polarization...
September 11, 2017: Immunologic Research
https://www.readbyqxmd.com/read/28868583/von-willebrand-factor-protects-against-acute-ccl4-induced-hepatotoxicity-through-phospho-p38-mapk-signaling-pathway-inhibition
#11
Hai-Jian Sun, Jian Chen, Hao Zhang, Bing Ni, Jennifer C van Velkinburgh, Yao Liu, Yu-Zhang Wu, Xia Yang
The blood glycoprotein von Willebrand factor (vWF) is involved in coagulopathy and inflammation; however, its role in the pathogenesis of acute liver failure, as suggested by its higher expression levels in such patients, remains unknown. In this study, vWF-knockout (KO) mice showed more severe carbon tetrachloride (CCl4)-induced liver injury than wild-type mice. Patients with acute liver injury also showed elevated vWF protein activity and expression in liver tissues, as compared to healthy individuals. Using the mouse model and cultured human umbilical vein endothelial cells (HUVECs), CCl4 was found to directly increase vWF protein expression through interaction with the highly expressed vWF receptor, GPIbα...
September 3, 2017: Immunologic Research
https://www.readbyqxmd.com/read/28845509/the-role-of-tgf-beta-signaling-in-dendritic-cell-tolerance
#12
REVIEW
Grace E Esebanmen, William H R Langridge
Transforming growth factor beta (TGF-β) is a pleiotropic cytokine present in vertebrate and invertebrate organisms that functions in numerous physiological and pathological processes. TGF-β impacts all the cells of the immune system, and of the three known TGF-β isoforms, TGF-β1 is the predominant isoform expressed in immune cells. TGF-β1 is known to play a pivotal role in the function of all immune cells especially in the regulation of T cell development and in the induction of immunological tolerance in dendritic cells (DCs)...
August 28, 2017: Immunologic Research
https://www.readbyqxmd.com/read/28822075/recycling-endosomes-in-human-cytotoxic-t-lymphocytes-constitute-an-auxiliary-intracellular-trafficking-pathway-for-newly-synthesized-perforin
#13
Kelsey Lesteberg, Jordan Orange, George Makedonas
Although cytotoxic T lymphocytes (CTLs) store perforin within cytoplasmic secretory granules for immediate use, perforin is synthesized anew within hours of TCR stimulation. Previously, we observed new perforin protein at an immunologic synapse independent of secretory lysosomes; herein, we aimed to determine how new perforin transits to the synapse if not via lytic granules. We analyzed antigen-specific human CTLs via imaging flow cytometry and high-resolution confocal microscopy, with attention to intracellular trafficking components and new perforin...
August 18, 2017: Immunologic Research
https://www.readbyqxmd.com/read/28808940/plasma-alpha-l-fucosidase-activity-in-chronic-inflammation-and-autoimmune-disorders-in-a-pediatric-cohort-of-hospitalized-patients
#14
Ildikó Endreffy, Geir Bjørklund, László Szerafin, Salvatore Chirumbolo, Mauricio A Urbina, Emőke Endreffy
Human α-fucosidase (EC 3.2.1.51) is an enzyme (hydrolase) of particular biological and medical interest, as the inherited deficiency in its activity leads to fucosidosis, a pathology belonging to severe glycoprotein lysosomal storage disorders. Although its importance has increased in latest years, data about its plasma level in children with inflammatory disorders are still lacking. In the present study, plasma activity of α-L-fucosidase-1 (FUCA-1) and its potential association with chronic inflammatory pathologies was evaluated in hospitalized individuals, both pediatric and adult ones...
August 14, 2017: Immunologic Research
https://www.readbyqxmd.com/read/28786023/siglec-7-expression-is-reduced-on-a-natural-killer-nk-cell-subset-of-obese-humans
#15
Philip Rosenstock, Rüdiger Horstkorte, Vinayaga Srinivasan Gnanapragassam, Jörg Harth, Heike Kielstein
Obesity leads to an altered adipocytokine production negatively effecting the function of natural killer cells (NK cells), which are important effector cells of the innate immune system. NK cells provide a defence against tumour cells or virus infected cells and have different activating and inhibitory surface receptors to distinguish between normal and transformed cells. One group of the inhibitory receptors are the sialic acid-binding immunoglobulin-like lectins (Siglecs). The aim of this study was to compare the expression of Siglecs-7, -9 and -10 on NK cells from normal weight and obese subjects...
August 7, 2017: Immunologic Research
https://www.readbyqxmd.com/read/28766095/signaling-interactions-predicted-by-the-tritope-model-of-the-tcr
#16
REVIEW
Melvin Cohn
As the data accumulates, it becomes obvious that the Standard Model of TCR structure-function relationships is in jeopardy. The proposed Tritope model has become more meaningful and, in any case, is richer in prediction and explanation. This is illustrated here by using the signaling interactions of the TCR as examples. An unsuspected signaling pathway for positive selection, and for alloreactivity, is predicted. Further, crucial data needed to elucidate the structural elements that distinguish signaling for restrictive- versus allo-reactivity are identified...
August 1, 2017: Immunologic Research
https://www.readbyqxmd.com/read/28762199/age-dependent-alterations-in-serum-cytokines-peripheral-blood-mononuclear-cell-cytokine-production-natural-killer-cell-activity-and-prostaglandin-f2%C3%AE
#17
Dong Hee Lee, Minkyung Kim, Minjoo Kim, Young Ju Lee, Hye Jin Yoo, Sang-Hyun Lee, Jong Ho Lee
This study aimed to determine age-dependent alterations in serum cytokines, peripheral blood mononuclear cell (PBMC) cytokine production, natural killer (NK) cell activity, and urinary 8-epi-prostaglandin F2α (PGF2α). Nine hundred eighty-seven healthy and nonobese subjects were divided into five age groups: 20-34 (group 1), 35-44 (group 2), 45-54 (group 3), 55-64 (group 4), and 65-80 (group 5) years of age. After adjusting for BMI, sex, and smoking and drinking status, serum interferon (IFN)-γ levels decreased in groups 3, 4, and 5 compared with those in groups 1 and 2...
July 31, 2017: Immunologic Research
https://www.readbyqxmd.com/read/28748328/potential-therapeutic-use-of-il-37-a-key-suppressor-of-innate-immunity-and-allergic-immune-responses-mediated-by-mast-cells
#18
REVIEW
Pio Conti, Francesco Carinci, Gianfranco Lessiani, Enrico Spinas, Spyridon K Kritas, Gianpaolo Ronconi, Alessandro Caraffa, Theoharis C Theoharides
The host response to either exogenous or endogenous insults produces a series of changes, characterized by alterations in immunological functions and generation of mediators called cytokines which include the interleukin-1 (IL-1) family members. IL-1 acts as a hormone mediating the host responses to infection and inflammation. Blocking inflammatory IL-1 family members can be effective against inflammatory disorders, including allergies. IL-37, (formerly IL-1 family member 7), emerges as an inhibitor of innate and adaptive immunity by reducing circulating and organ cytokine levels...
July 26, 2017: Immunologic Research
https://www.readbyqxmd.com/read/28744806/interleukin-10-production-and-t-cell-suppressive-capacity-in-b-cell-subsets-from-atherosclerotic-apoe-mice
#19
Héctor Rincón-Arévalo, Janny Villa-Pulgarín, Jorge Tabares, Mauricio Rojas, Gloria Vásquez, José R Ramírez-Pineda, Diana Castaño, Lina M Yassin
The evidence regarding the role of regulatory B cells (Breg) in atherosclerosis are scarce, and there are contradictory data about their atheroprotective properties. Due to the demonstrated protective function of Breg in different inflammatory diseases mainly through interleukin-10 (IL-10) production, the knowledge of their participation in atherosclerosis immunopathology would be very valuable. To further study which B cell subsets participate in IL-10 production and their regulatory role, splenocytes from apolipoprotein-E-deficient mice were evaluated by ex vivo and in vitro cultures...
July 25, 2017: Immunologic Research
https://www.readbyqxmd.com/read/28752199/thymus-vulgaris-l-and-thymol-assist-murine-macrophages-raw-264-7-in-the-control-of-in-vitro-infections-by-staphylococcus-aureus-pseudomonas-aeruginosa-and-candida-albicans
#20
Jonatas Rafael de Oliveira, Leandro Wagner Figueira, Fábia Lugli Sper, Vanessa Marques Meccatti, Samira Esteves Afonso Camargo, Luciane Dias de Oliveira
Microorganisms are capable to combat defense cells by means of strategies that contribute to their stabilization and proliferation in invaded tissues. Frequently antimicrobial-resistant strains appear; therefore, alternative methods to control them must be investigated, for example, the use of plant products. The capacity of the thyme extract (Thymus vulgaris L.) and phytocompound thymol in the control of in vitro infections by Staphylococcus aureus, Pseudomonas aeruginosa, and Candida albicans in murine macrophages (RAW 264...
August 2017: Immunologic Research
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