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Immunologic Research

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https://www.readbyqxmd.com/read/28508945/clinical-efficacy-of-percutaneous-cryoablation-combined-with-allogenic-nk-cell-immunotherapy-for-advanced-non-small-cell-lung-cancer
#1
Mao Lin, Shu-Zhen Liang, Xiao-Hua Wang, Ying-Qing Liang, Ming-Jie Zhang, Li-Zhi Niu, Ji-Bing Chen, Hai-Bo Li, Ke-Cheng Xu
In this study, the safety and clinical efficacy of cryosurgery combined with allogenic NK cell immunotherapy for the treatment of advanced non-small cell lung cancer (NSCLC) were evaluated. From July 2016 to March 2017, we enrolled 60 patients who met the enrollment criteria and divided them into two groups: (1) the simple cryoablation group (n = 30) and (2) the cryoablation combined with allogenic NK cell group (n = 30). The changes in immune function, quality of life, and clinical response were evaluated...
May 16, 2017: Immunologic Research
https://www.readbyqxmd.com/read/28488090/pathogenesis-of-systemic-sclerosis-current-concept-and-emerging-treatments
#2
REVIEW
Masutaka Furue, Chikage Mitoma, Hiroki Mitoma, Gaku Tsuji, Takahito Chiba, Takeshi Nakahara, Hiroshi Uchi, Takafumi Kadono
Systemic sclerosis (SSc) is an intractable multifaceted disease with high mortality. Although its pathogenesis is not fully understood, recent studies have advanced our knowledge on SSc. The cardinal pathological features of SSc are autoimmunity, vasculopathy, and fibrosis. The B cells in SSc are constitutively activated and lead to the production of a plethora of autoantibodies, such as anti-topoisomerase I and anti-centromere antibodies. In addition to these autoantibodies, which are valuable for diagnostic criteria or biomarkers, many other autoantibodies targeting endothelial cells, including endothelin type A receptor and angiotensin II type I receptor, are known to be functional and induce activation or apoptosis of endothelial cells...
May 9, 2017: Immunologic Research
https://www.readbyqxmd.com/read/28478499/the-levels-of-dngr-1-and-its-ligand-bearing-cells-were-altered-after-human-and-simian-immunodeficiency-virus-infection
#3
Wen-Rong Yao, Dong Li, Lei Yu, Feng-Jie Wang, Hui Xing, Gui-Bo Yang
Dendritic cell NK lectin Group Receptor-1 (DNGR-1), also known as C-type lectin domain family 9, member A (CLEC9A), is a member of C-type lectin receptor superfamily expressed primarily on dendritic cells (DC) that excel in cross-presentation of exogenous antigens. To find out whether and how it is affected in human immunodeficiency virus infections or acquired immunodeficiency syndromes (HIV/AIDS), DNGR-1 expression and DNGR-1-binding cells in simian/human immunodeficiency virus (SHIV) and simian immunodeficiency virus (SIV)-infected rhesus macaques and antiretroviral therapy (ART)-treated AIDS patients were examined by real-time RT-PCR, flow cytometry, and confocal microscopy...
May 6, 2017: Immunologic Research
https://www.readbyqxmd.com/read/28456882/the-nlrp3-and-casp1-gene-polymorphisms-are-associated-with-developing-of-acute-coronary-syndrome-a-case-control-study
#4
Hector Gonzalez-Pacheco, Gilberto Vargas-Alarcon, Javier Angeles-Martinez, Carlos Martinez-Sanchez, Oscar Perez-Mendez, Gabriel Herrera-Maya, Marco Antonio Martinez-Rios, Marco Antonio Peña-Duque, Carlos Posadas-Romero, Jose Manuel Fragoso
The protein products of NLRP3 and CASP1 genes are involved in the cleavage of pro-IL-1B and pro-IL-18 leading to the active cytokines, which play an important role in the development of the acute coronary syndrome (ACS). The aim of the present study was to evaluate whether NLRP3 and CASP1 gene polymorphisms are biomarkers of ACS susceptibility in Mexican population. Two polymorphisms of the CASP1 gene [G+7/in6A (rs501192) and A10370-G Exon-6 (rs580253)] and one of the NLRP3 gene [UTR'3 G37562-C (rs10754558)] were genotyped by 5' exonuclease TaqMan assays in a group of 617 patients with ACS and 609 control individuals...
April 30, 2017: Immunologic Research
https://www.readbyqxmd.com/read/28456881/haplotype-analysis-of-il-10-gene-polymorphism-in-couples-with-spontaneous-abortions-and-aborted-fetuses
#5
M Vidyadhari, M Sujatha, P Krupa, Pratibha Nallari, A Venkateshwari
Spontaneous abortion is the loss of pregnancy during an early gestational period. Interleukin-10 is an anti-inflammatory cytokine which plays an important role in successful pregnancy outcome. The aim of the study is to elucidate an association of IL-10 gene promoter polymorphisms (-1082G/A, -819 C/T, -592C/A) in spontaneous abortions from Telangana state of South India. The present population-based retrospective case-control triad study includes a total of 80 case families with spontaneous abortions and 100 control families with medically terminated pregnancies...
April 29, 2017: Immunologic Research
https://www.readbyqxmd.com/read/28432603/immunoprophylaxis-of-multi-antigen-peptide-map-vaccine-for-human-lymphatic-filariasis
#6
Christiana Immanuel, Aparnaa Ramanathan, Malathi Balasubramaniyan, Vishal Kishor Khatri, Nitin Purushottam Amdare, Donthamsetty Nageswara Rao, Maryada Venkata Rami Reddy, Kaliraj Perumal
Human lymphatic filariasis, the parasitic disease caused by the filarial nematodes Wuchereria bancrofti, Brugia malayi, and Brugia timori, is ranked as the second most complex clinical condition leading to permanent and long-term disability. The multiple antigen peptide (MAP) approach is an effective method to chemically synthesize and deliver multiple T and B cell epitopes as the constituents of a single immunogen. Here, we report on the design, chemical synthesis, and immunoprophylaxis of three epitopes that have been identified from promising vaccine candidates reported in our previous studies, constructed as MAP on an inert lysine core for human lymphatic filariasis in Jird model...
April 21, 2017: Immunologic Research
https://www.readbyqxmd.com/read/28405920/effector-functions-of-memory-ctls-can-be-affected-by-signals-received-during-reactivation
#7
Yingjun Lv, Elliot Mattson, Anjuli Bhadurihauck, Karla Garcia, Lei Li, Zhengguo Xiao
Memory cytotoxic T lymphocytes (CTLs) are able to provide protections to the host against repeated insults from intracellular pathogens. However, it has not been completely understood how the effector functions of memory CTLs are induced upon antigen challenge, which is directly related to the efficacy of their protection. Third signal cytokines, such as IL-12 and type I interferon, have been suggested to be involved in the protective function of memory CTLs, but direct evidence is warranted. In this report, we found that memory CTLs need to be reactivated to exert effector functions...
April 12, 2017: Immunologic Research
https://www.readbyqxmd.com/read/28391374/resolution-of-inflammation-pathways-in-preeclampsia-a-narrative-review
#8
REVIEW
Luiza Oliveira Perucci, Mário Dias Corrêa, Luci Maria Dusse, Karina Braga Gomes, Lirlândia Pires Sousa
Preeclampsia (PE) is one of the leading causes of maternal morbidity and mortality worldwide. This disease is believed to occur in two stages with placental dysfunction in early pregnancy leading to maternal clinical findings after 20 weeks of gestation, as consequence of systemic inflammation, oxidative stress, and endothelial dysfunction. Much evidence suggests that PE women display an overshooting inflammatory response throughout pregnancy due to an unbalanced regulation of innate and adaptive immune responses...
April 8, 2017: Immunologic Research
https://www.readbyqxmd.com/read/28378118/mir-451-limits-cd4-t-cell-proliferative-responses-to-infection-in-mice
#9
Lesley M Chapman, Sara K Ture, David J Field, Craig N Morrell
MicroRNAs (miRNAs) are major regulators of cell responses, particularly in stressed cell states and host immune responses. Some miRNAs have a role in pathogen defense, including regulation of immune responses to Plasmodium parasite infection. Using a nonlethal mouse model of blood stage malaria infection, we have found that miR-451(-/-) mice infected with Plasmodium yoelii XNL cleared infection at a faster rate than did wild-type (WT) mice. MiR-451(-/-) mice had an increased leukocyte response to infection, with the protective phenotype primarily driven by CD4(+) T cells...
April 4, 2017: Immunologic Research
https://www.readbyqxmd.com/read/28367602/myeloid-cells-expressing-high-level-of-cd45-are-associated-with-a-distinct-activated-phenotype-in-glioma
#10
Susan Brandenburg, Kati Turkowski, Annett Mueller, Yordan T Radev, Sabine Seidlitz, Peter Vajkoczy
Glioblastoma multiforme is characterized by high accumulation of microglia/macrophages. The function of these tumor-infiltrating myeloid cells is not sufficiently elucidated. Therefore, a better understanding of the precise immune cell composition and function in brain tumors is required. In rodent glioma models, two different myeloid cell populations exist, determined by the expression level of CD45, namely CD11b(+)CD45(low) and CD11b(+)CD45(high). Previous analyses of cytokine and marker expression profiles were almost exclusively performed on the entire myeloid cell fraction...
April 3, 2017: Immunologic Research
https://www.readbyqxmd.com/read/28357565/anti-glomerular-basement-membrane-glomerulonephritis-with-thrombotic-microangiopathy-a-case-report
#11
Xiao-Juan Yu, Sha-Sha Han, Su-Xia Wang, Xiao-Yu Jia, Wei-Yi Guo, Zhao Cui, Feng Yu, Fu-de Zhou, Ming-Hui Zhao
No abstract text is available yet for this article.
March 29, 2017: Immunologic Research
https://www.readbyqxmd.com/read/28349250/curcumin-improves-treatment-outcome-of-takayasu-arteritis-patients-by-reducing-tnf-%C3%AE-a-randomized-placebo-controlled-double-blind-clinical-trial
#12
Nan Shao, Huixin Jia, Yiwen Li, Jingying Li
Tumor necrosis factor (TNF) inhibitors have been found to exhibit certain efficacy in treating refractory Takayasu arteritis (TA) in clinic despite severe adverse effects. The aim of this study is to investigate a natural anti-TNF compound, curcumin, its function, and its potential as treatment against TA. In total, 246 patients who were diagnosed of acute TA participated have completed this clinical trial. They were randomly assigned in either treatment group or control group, in which they were daily administered with curcumin or placebo accordingly for 4 weeks with weekly revisits for data collection...
March 27, 2017: Immunologic Research
https://www.readbyqxmd.com/read/28332072/are-the-autoimmune-inflammatory-syndrome-induced-by-adjuvants-asia-and-the-undifferentiated-connective-tissue-disease-uctd-related-to-each-other-a-case-control-study-of-environmental-exposures
#13
F Scanzi, L Andreoli, M Martinelli, M Taraborelli, I Cavazzana, N Carabellese, R Ottaviani, F Allegri, F Franceschini, N Agmon-Levin, Y Shoenfeld, Angela Tincani
The autoimmune/inflammatory syndrome induced by adjuvants (ASIA) is an entity that includes different autoimmune conditions observed after exposure to an adjuvant. Patients with undifferentiated connective tissue disease (UCTD) present many signs and symptoms of ASIA, alluding to the idea that an exposure to adjuvants can be a trigger also for UCTD. The aim of this case-control study was to investigate exposure to adjuvants prior to disease onset in patients affected by UCTD. Ninety-two UCTD patients and 92 age- and sex-matched controls with no malignancy, chronic infections, autoimmune disease nor family history of autoimmune diseases were investigated for exposure to adjuvants...
March 22, 2017: Immunologic Research
https://www.readbyqxmd.com/read/28324219/prolactin-and-systemic-lupus-erythematosus
#14
LETTER
Beuy Joob, Viroj Wiwanitkit
No abstract text is available yet for this article.
March 21, 2017: Immunologic Research
https://www.readbyqxmd.com/read/28303447/editorial-cutting-edge-in-systemic-lupus-erythematosus
#15
David P D'Cruz, Annegret Kuhn
No abstract text is available yet for this article.
March 16, 2017: Immunologic Research
https://www.readbyqxmd.com/read/28286920/blockade-of-notch-signaling-promotes-acetaminophen-induced-liver-injury
#16
Longfeng Jiang, Michael Ke, Shi Yue, Wen Xiao, Youde Yan, Xiaozhao Deng, Qi-Long Ying, Jun Li, Bibo Ke
Liver injury after experimental acetaminophen treatment is mediated both by direct hepatocyte injury through a P450-generated toxic metabolite and indirectly by activated liver Kupffer cells and neutrophils. This study was designed to investigate the role of Notch signaling in the regulation of innate immune responses in acetaminophen (APAP)-induced liver injury. Using a mouse model of APAP-induced liver injury, wild-type (WT) and toll-like receptor 4 knockout (TLR4 KO) mice were injected intraperitoneally with APAP or PBS...
March 13, 2017: Immunologic Research
https://www.readbyqxmd.com/read/28285414/a-population-association-study-of-vitamin-d-receptor-gene-polymorphisms-and-haplotypes-with-the-risk-of-systemic-lupus-erythematosus-in-a-chinese-population
#17
Xu-E Chen, Pu Chen, Shan-Shan Chen, Jin Lu, Ting Ma, Guang Shi, Ya Zhou, Ji Li, Liang Sheng
The aim of the study is to investigate the association of vitamin D receptor (VDR) gene polymorphism, additional gene-gene interaction, and haplotype combination with systemic lupus erythematosus (SLE) risk. Pairwise linkage disequilibrium (LD) analysis was conducted using SNPstats. The association between four SNPs within VDR gene and SLE risk was investigated by logistic regression. Generalized multifactor dimensionality reduction (GMDR) was used to analyze the interaction among four SNPs. Four SNPs within VDR gene were selected for genotyping in this study, including rs2228570, rs1544410, rs7975232, and rs731236...
March 11, 2017: Immunologic Research
https://www.readbyqxmd.com/read/28258348/neutralization-of-nerve-growth-factor-ngf-inhibits-the-th2-response-and-protects-against-the-respiratory-syncytial-virus-rsv-infection
#18
Xiaorong Wu, Xiong Zhou, Yuxiang Hu, Chao Liu, Jun Wang
Increasing evidence suggests that respiratory syncytial virus (RSV) infection during the early life is an important risk factor for the development of asthma. RSV infection is associated with neurogenic inflammation in the airways along with the increased expression of nerve growth factor (NGF). However, the role of NGF in RSV infection is not clear. In this study, we infected the rat with RSV and treated these animals with anti-NGF neutralization antibody. We found that anti-NGF treatment significantly alleviated the lung inflammation as evidenced by decreased inflammatory infiltration and decreased airway resistance...
March 3, 2017: Immunologic Research
https://www.readbyqxmd.com/read/28233089/the-microbiome-and-systemic-lupus-erythematosus
#19
Nurit Katz-Agranov, Gisele Zandman-Goddard
The microbiota, which is comprised of the collective of all microbes inhabiting the gut and its effect on the human host in which it resides, has become a growing field of interest. Various parameters of health and disease have been found to be associated with the variation in the human gut microbiome. In recent years, many studies have demonstrated an important role of gut microbes in the development of various illnesses including autoimmune diseases, such as type 1 diabetes, rheumatoid arthritis, and multiple sclerosis...
February 23, 2017: Immunologic Research
https://www.readbyqxmd.com/read/28229285/topics-on-vitamin-d-in-systemic-lupus-erythematosus-analysis-of-evidence-and-critical-literature-review
#20
António Marinho, Mariana Taveira, Carlos Vasconcelos
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with multiorgan inflammation, linked to the loss of immune tolerance to self-antigens and the production of a diversity of autoantibodies. The phenotype and progression of SLE have been linked to a combination of environmental, genetic, and hormonal factors. One such environmental factor is vitamin D, a vital hormone with well-established effects on mineral metabolism, skeletal health, and effects on cardiovascular system. The purpose of this article is to make the analysis of evidence and literature review of the pleomorphic effects of Vitamin D in SLE...
February 22, 2017: Immunologic Research
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