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Movement Disorders: Official Journal of the Movement Disorder Society

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https://www.readbyqxmd.com/read/30403835/abnormal-sensory-gating-in-patients-with-different-types-of-focal-dystonias
#1
Antonella Conte, Daniele Belvisi, Maria Ilenia De Bartolo, Nicoletta Manzo, Francesca Natalia Cortese, Matteo Tartaglia, Gina Ferrazzano, Giovanni Fabbrini, Alfredo Berardelli
BACKGROUND: Movement execution in healthy individuals increases the somatosensory temporal discrimination threshold. These changes are a result of mechanisms of sensory gating at the subcortical level. Although the somatosensory temporal discrimination threshold is abnormally increased in patients with focal dystonias, the effect of movement execution on somatosensory temporal discrimination in dystonic patients is unknown. OBJECTIVES: The objective of this study was to determine whether somatosensory temporal discrimination threshold modulation induced by voluntary movement is normal in different forms of focal dystonia...
November 7, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/30398676/familial-ataxia-tremor-and-dementia-in-a-polish-family-with-a-novel-mutation-in-the-ccdc88c-gene
#2
LETTER
Marta Leńska-Mieciek, Agnieszka Charzewska, Leszek Królicki, Dorota Hoffman-Zacharska, Zhefan Stephen Chen, Kwok-Fai Lau, Ho Yin Edwin Chan, Tomasz Gambin, Urszula Fiszer
No abstract text is available yet for this article.
November 6, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/30398675/ptrhd1-loss-of-function-mutation-in-an-african-family-with-juvenile-onset-parkinsonism-and-intellectual-disability
#3
Demy J S Kuipers, Jonathan Carr, Soraya Bardien, Pearl Thomas, Boiketlo Sebate, Guido J Breedveld, Rick van Minkelen, Rutger W W Brouwer, Wilfred F J van Ijcken, Marjon A van Slegtenhorst, Vincenzo Bonifati, Marialuisa Quadri
BACKGROUND: The genetic bases of PD in sub-Saharan African (SSA) populations remain poorly characterized, and analysis of SSA families with PD might lead to the discovery of novel disease-related genes. OBJECTIVES: To investigate the clinical features and identify the disease-causing gene in a black South African family with 3 members affected by juvenile-onset parkinsonism and intellectual disability. METHODS: Clinical evaluation, neuroimaging studies, whole-exome sequencing, homozygosity mapping, two-point linkage analysis, and Sanger sequencing of candidate variants...
November 6, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/30398674/mediterranean-diets-and-prodromal-parkinson-s-disease-a-causal-line-or-a-confound-circle
#4
Ronald B Postuma
No abstract text is available yet for this article.
November 6, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/30398673/targeting-the-pedunculopontine-nucleus-in-parkinson-s-disease-time-to-go-back-to-the-drawing-board
#5
Roger L Albin, D James Surmeier, Cecilia Tubert, Martin Sarter, Martijn L T M Müller, Nicolaas I Bohnen, William T Dauer
No abstract text is available yet for this article.
November 6, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/30397942/diet-to-beat-the-odds-of-prodromal-parkinson-s-disease
#6
Christy C Tangney
No abstract text is available yet for this article.
November 5, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/30387904/pimavanserin-for-parkinson-s-disease-psychosis-effects-stratified-by-baseline-cognition-and-use-of-cognitive-enhancing-medications
#7
Alberto J Espay, Michael T Guskey, James C Norton, Bruce Coate, Joaquin A Vizcarra, Clive Ballard, Stewart A Factor, Joseph H Friedman, Anthony E Lang, Niccole J Larsen, Candace Andersson, Doral Fredericks, Daniel Weintraub
BACKGROUND: PD psychosis is often associated with cognitive impairment, including dementia, and involves dopaminergic, serotonergic, and cholinergic mechanisms. OBJECTIVE: To evaluate the differential effect of the antipsychotic pimavanserin, a selective serotonin 2A receptor inverse agonist, in PD psychosis patients with versus without cognitive impairment and in those receiving versus not receiving cognitive-enhancing medications. METHODS: Data from the pivotal randomized clinical trial of pimavanserin for PD psychosis were stratified by (1) screening MMSE score as cognitively impaired (21-24) versus unimpaired (≥25) and (2) concomitant use versus nonuse of cognitive-enhancing medications...
November 2, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/30383315/adverse-event-reporting-in-clinical-trials-in-parkinson-s-disease-time-for-change
#8
C Warren Olanow, Christopher Kenney, Stephen Bandak, Karl D Kieburtz
No abstract text is available yet for this article.
November 1, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/30379360/motor-cortical-excitability-during-voluntary-inhibition-of-involuntary-tic-movements
#9
Christos Ganos, Lorenzo Rocchi, Anna Latorre, Leanne Hockey, Clare Palmer, Eileen M Joyce, Kailash P Bhatia, Patrick Haggard, John Rothwell
BACKGROUND: Tics can be voluntarily inhibited. However, the neurophysiology of voluntary tic inhibition remains underexplored. The objective of this study was to explore state-dependent effects of voluntary tic inhibition on M1 excitability. METHODS: Neurophysiological assessments (single motor-evoked potentials, corticospinal recruitment curves, short-interval intracortical inhibition, H-reflex) were performed in 14 adults with Tourette syndrome during voluntary tic inhibition and free ticcing...
October 31, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/30376603/high-frequency-somatosensory-stimulation-in-dystonia-evidence-fordefective-inhibitory-plasticity
#10
Roberto Erro, Lorenzo Rocchi, Elena Antelmi, Rocco Liguori, Michele Tinazzi, Alfredo Berardelli, John Rothwell, Kailash P Bhatia
BACKGROUND: Apart from motor symptoms, multiple deficits of sensory processing have been demonstrated in dystonia. The most consistent behavioural measure of this is abnormal somatosensory temporal discrimination threshold, which has recently been associated with physiological measures of reduced inhibition within the primary somatosensory area. High-frequency repetitive sensory stimulation is a patterned electric stimulation applied to the skin through surface electrodes that has been recently reported to shorten somatosensory temporal discrimination in healthy subjects and to increase the resting level of excitability in several different types of inhibitory interaction in the somatosensory and even motor areas...
October 30, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/30376184/habitual-exercisers-versus-sedentary-subjects-with-parkinson-s-disease-multimodal-pet-and-fmri-study
#11
Matthew A Sacheli, Danielle K Murray, Nasim Vafai, Mariya V Cherkasova, Katie Dinelle, Elham Shahinfard, Nicole Neilson, Jessamyn McKenzie, Michael Schulzer, Silke Appel-Cresswell, Martin J McKeown, Vesna Sossi, A Jon Stoessl
BACKGROUND: The benefits of exercise in PD have been linked to enhanced dopamine (DA) transmission in the striatum. OBJECTIVE: To examine differences in DA release, reward signaling, and clinical features between habitual exercisers and sedentary subjects with PD. METHODS: Eight habitual exercisers and 9 sedentary subjects completed [11 C]raclopride PET scans before and after stationary cycling to determine exercise-induced release of endogenous DA in the dorsal striatum...
October 30, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/30357936/genotype-phenotype-relations-for-the-parkinson-s-disease-genes-snca-lrrk2-vps35-mdsgene-systematic-review
#12
REVIEW
Joanne Trinh, Florentine M J Zeldenrust, Jana Huang, Meike Kasten, Susen Schaake, Sonja Petkovic, Harutyun Madoev, Anne Grünewald, Shahad Almuammar, Inke R König, Christina M Lill, Katja Lohmann, Christine Klein, Connie Marras
This comprehensive MDSGene review is devoted to the three autosomal-dominant PD forms: PARK-SNCA, PARK-LRRK2, and PARK-VPS35. It follows MDSGene's standardized data extraction protocol, screened a total of 2,972 citations, and is based on fully curated phenotypic and genotypic data on 937 patients with dominantly inherited PD attributed to 44 different mutations in SNCA, LRRK2, or VPS35. All of these data are also available in an easily searchable online database (www.mdsgene.org), which additionally provides descriptive summary statistics on phenotypic and genetic data...
October 24, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/30357911/an-update-on-adaptive-deep-brain-stimulation-in-parkinson-s-disease
#13
REVIEW
Jeroen G V Habets, Margot Heijmans, Mark L Kuijf, Marcus L F Janssen, Yasin Temel, Pieter L Kubben
Advancing conventional open-loop DBS as a therapy for PD is crucial for overcoming important issues such as the delicate balance between beneficial and adverse effects and limited battery longevity that are currently associated with treatment. Closed-loop or adaptive DBS aims to overcome these limitations by real-time adjustment of stimulation parameters based on continuous feedback input signals that are representative of the patient's clinical state. The focus of this update is to discuss the most recent developments regarding potential input signals and possible stimulation parameter modulation for adaptive DBS in PD...
October 24, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/30345712/cortical-dynamics-within-and-between-parietal-and-motor-cortex-in-essential-tremor
#14
Arnab Roy, Stephen A Coombes, Jae Woo Chung, Derek B Archer, Michael S Okun, Christopher W Hess, Aparna Wagle Shukla, David E Vaillancourt
BACKGROUND: Evidence from functional imaging in essential tremor suggests that activity within parietal and motor cortices may be associated with worsening of tremor at increased visual feedback. OBJECTIVES: Examine how cortical oscillations within these regions and the connectivity between these regions is associated with worsening of tremor in essential tremor in response to high visual feedback. METHOD: The study included 24 essential tremor participants and 17 controls...
October 21, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/30345602/electroencephalography-based-machine-learning-for-cognitive-profiling-in-parkinson-s-disease-preliminary-results
#15
Nacim Betrouni, Arnaud Delval, Laurence Chaton, Luc Defebvre, Annelien Duits, Anja Moonen, Albert F G Leentjens, Kathy Dujardin
BACKGROUND: Cognitive symptoms are common in patients with Parkinson's disease. Characterization of a patient's cognitive profile is an essential step toward the identification of predictors of cognitive worsening. OBJECTIVE: The aim of this study was to investigate the use of the combination of resting-state EEG and data-mining techniques to build characterization models. METHODS: Dense EEG data from 118 patients with Parkinson's disease, classified into 5 different groups according to the severity of their cognitive impairments, were considered...
October 21, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/30345542/higher-serum-triglyceride-levels-are-associated-with-parkinson-s-disease-mild-cognitive-impairment
#16
LETTER
Xinxin Huang, Samuel Yong-Ern Ng, Nicole Shuang-Yu Chia, Sanchalika Acharyya, Fiona Setiawan, Zhonghao Lu, Yi Jayne Tan, Ebonne Ng, Ming-Ching Wen, Adeline S L Ng, Kay-Yaw Tay, Wing-Lok Au, Eng-King Tan, Louis Chew-Seng Tan
No abstract text is available yet for this article.
October 21, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/30345538/pde10a-and-adcy5-mutations-linked-to-molecular-and-microstructural-basal-ganglia-pathology
#17
Flavia Niccolini, Niccolo E Mencacci, Tayyabah Yousaf, Eugenii A Rabiner, Vincenzo Salpietro, Gennaro Pagano, Bettina Balint, Stephanie Efthymiou, Henry Houlden, Roger N Gunn, Nicholas Wood, Kailash P Bhatia, Marios Politis
BACKGROUND: Striatal cyclic adenosine monophosphate activity modulates movement and is determined from the balance between its synthesis by adenylate cyclase 5 (ADCY5) and its degradation by phosphodiesterase 10A (PDE10A). OBJECTIVE: We assessed the integrity of striatocortical pathways, in vivo, in 2 genetic hyperkinetic disorders caused by ADCY5 and PDE10A mutations. METHODS: We studied 6 subjects with PDE10A and ADCY5 mutations using [11 C]IMA107 PET, [123 I]FP-CIT Single-photon emission computed tomography (SPECT) and multimodal MRI to investigate PDE10A and dopamine transporter availability, neuromelanin-containing neurons, and microstructural white and gray matter changes, respectively...
October 21, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/30338868/systematic-review-of-movement-disorders-and-oculomotor-abnormalities-in-whipple-s-disease
#18
Julien F Bally, Aurélie Méneret, Emmanuel Roze, Melanie Anderson, David Grabli, Anthony E Lang
Whipple's disease, affecting the CNS, can cause a wide variety of symptoms. Movement disorders are very prevalent, and some are pathognomonic of the disease. This systematic review analyzed all published cases of movement disorders because of CNS Whipple's disease, providing detailed information on clinical and associated features. We have also attempted to address sources of confusion in the literature, particularly related to differing uses of the terminology of movement disorder. This comprehensive overview of Whipple's disease-induced movement disorders aims to aid neurologists in recognizing this very rare disorder and successfully reaching a laboratory-confirmed diagnosis in order to initiate appropriate therapy...
October 19, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/30334277/delineating-cerebellar-mechanisms-in-dyt11-myoclonus-dystonia
#19
Anna Sadnicka, Joseph M Galea, Jui-Cheng Chen, Thomas T Warner, Kailash P Bhatia, John C Rothwell, Mark J Edwards
BACKGROUND: Recent research has highlighted the role of the cerebellum in the pathophysiology of myoclonus-dystonia syndrome as a result of mutations in the ɛ-sarcoglycan gene (DYT11). Specifically, a cerebellar-dependent saccadic adaptation task is dramatically impaired in this patient group. OBJECTIVES: The objective of this study was to investigate whether saccadic deficits coexist with impairments of limb adaptation to provide a potential mechanism linking cerebellar dysfunction to the movement disorder within symptomatic body regions...
October 17, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/30329183/interrater-and-intrarater-agreement-on-the-2018-consensus-statement-on-classification-of-tremors
#20
LETTER
Roopa Rajan, Sanjay Pandey, Reghu Anandapadmanabhan, Achal K Srivastava
No abstract text is available yet for this article.
October 17, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
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