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Movement Disorders: Official Journal of the Movement Disorder Society

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https://www.readbyqxmd.com/read/28319282/stereotactic-radiosurgery-for-essential-tremor-retrospective-analysis-of-a-19-year-experience
#1
Ajay Niranjan, Sudesh S Raju, Ali Kooshkabadi, Edward Monaco, John C Flickinger, L Dade Lunsford
BACKGROUND: Essential Tremor (ET) is a common movement disorder that can be disabling. Initial treatment is in the form of medical therapies. Patients with medically refractory ET seek surgical intervention which include radiofrequency thalamotomy, deep brain stimulation, and radiosurgical thalamotomy. Radiosurgical thalamotomy is a minimally invasive surgical option which is especially valuable for elderly and high surgical risk patients. OBJECTIVE: The purpose of this study was to retrospectively analyze the outcomes of stereotactic radiosurgery for patients suffering from medically refractory essential tremor...
March 20, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28276091/ataxia-with-oculomotor-apraxia-is-associated-with-the-dna-damage-repair-pathway
#2
Christos Ganos, Jose Bras
No abstract text is available yet for this article.
March 9, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28256108/prodromal-spinocerebellar-ataxia-type-2-prospects-for-early-interventions-and-ethical-challenges
#3
REVIEW
Luis Velázquez-Pérez, Roberto Rodríguez-Labrada, José Miguel Laffita-Mesa
The characterization of prodromal stages in neurodegenerative disorders is becoming increasingly important because of the need for early neuroprotective therapies. Research during the past 3 decades in spinocerebellar ataxia type 2 has revealed a large body of evidence suggesting that many disease features precede the manifest cerebellar syndrome, which delineates the prodromal stage of this disorder. This stage is defined by clinical, imaging, and functional criteria, which are supported by early molecular events demonstrated in animal models...
March 3, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28256103/response-to-letter-by-saenz-farret-et-al-on-rating-scales-for-behavioral-symptoms-in-huntington-s-disease-critique-and-recommendations
#4
LETTER
Tiago A Mestre, Erik van Duijn, Aileen M Davis, Anne-Catherine Bachoud-Lévi, Monica Busse, Karen E Anderson, Cristina Sampaio, Christopher G Goetz, Esther Cubo, Glenn T Stebbins, Pablo Martinez-Martin
No abstract text is available yet for this article.
March 3, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28256098/neuropsychiatric-symptoms-and-premanifest-huntington-s-disease
#5
LETTER
Michel Saenz-Farret, Carlos Zúñiga-Ramirez, Carolina Candelaria Ramirez-Gomez, Veronica Montilla-Uzcategui, Federico Micheli
No abstract text is available yet for this article.
March 3, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28256092/prevalence-and-burden-of-dysautonomia-in-advanced-parkinson-s-disease
#6
LETTER
Aristide Merola, Alberto Romagnolo, Cristoforo Comi, Michela Rosso, Carlo Alberto Artusi, Maurizio Zibetti, Michele Lanotte, Andrew P Duker, Simona Maule, Leonardo Lopiano, Alberto J Espay
No abstract text is available yet for this article.
March 3, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28256089/striatal-activation-by-optogenetics-induces-dyskinesias-in-the-6-hydroxydopamine-rat-model-of-parkinson-disease
#7
Ledia F Hernández, Ivan Castela, Irene Ruiz-DeDiego, Jose A Obeso, Rosario Moratalla
BACKGROUND: Long-term levodopa (l-dopa) treatment is associated with the development of l-dopa-induced dyskinesias in the majority of patients with Parkinson disease (PD). The etiopathogonesis and mechanisms underlying l-dopa-induced dyskinesias are not well understood. METHODS: We used striatal optogenetic stimulation to induce dyskinesias in a hemiparkinsonian model of PD in rats. Striatal dopamine depletion was induced unilaterally by 6-hydroxydopamine injection into the medial forebrain bundle...
March 3, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28256044/striato-cortical-connections-in-parkinson-s-and-alzheimer-s-diseases-relation-to-cognition
#8
Lubomira Anderkova, Marek Barton, Irena Rektorova
BACKGROUND: Functional connectivity is abnormal in PD and in early Alzheimer's disease. OBJECTIVES: The objective of this study was to evaluate resting-state striato-cortical connectivity in PD and Alzheimer's disease and assess their relation to cognitive outcomes. Groups with mild cognitive impairment as a result of different pathologies (PD vs. Alzheimer's disease) were also compared. METHODS: Seed-based connectivity of the dorsal, middle, and ventral striatum was analyzed in 111 patients using functional MRI...
March 3, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28256013/urinary-dysfunction-in-early-de-novo-patients-with-parkinson-s-disease
#9
LETTER
Gennaro Pagano, Flavia Niccolini, Tayyabah Yousaf, Heather Wilson, Sotirios Polychronis, Kallol Ray Chaudhuri, Marios Politis
No abstract text is available yet for this article.
March 3, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28256010/striatal-d1-medium-spiny-neuron-activation-induces-dyskinesias-in-parkinsonian-mice
#10
Xiomara A Perez, Danhui Zhang, Tanuja Bordia, Maryka Quik
BACKGROUND: Dyskinesias are a disabling motor complication that arises with prolonged l-dopa treatment. Studies using D1 receptor drugs and genetically modified mice suggest that medium spiny neurons expressing D1 receptors play a primary role in l-dopa-induced dyskinesias. However, the specific role of these neurons in dyskinesias is not fully understood. METHODS: We used optogenetics, which allows for precise modulation of select neurons in vivo, to investigate whether striatal D1-expressing medium spiny neuron activity regulates abnormal involuntary movements or dyskinesia in parkinsonian mice...
March 3, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28256006/in-vivo-cortical-tau-in-parkinson-s-disease-using-18f-av-1451-positron-emission-tomography
#11
Allan K Hansen, Malene Flensborg Damholdt, Tatyana D Fedorova, Karoline Knudsen, Peter Parbo, Rola Ismail, Karen Østergaard, David J Brooks, Per Borghammer
BACKGROUND: Alzheimer's disease copathology is common in PD at autopsy. In non-PD subjects with mild cognitive impairment, tau depositions can be detected using 18F-AV-1451 PET. We hypothesized that 18F-AV-1451 PET would show tau aggregation in PD with mild cognitive impairment and correlate with cognitive dysfunction. OBJECTIVES: To describe tau aggregation in PD patients. METHODS: Twenty-six PD patients and 23 controls had 18F-AV-1451 PET and neuropsychological assessment to detect mild cognitive impairment...
March 3, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28251677/mitochondrial-dna-and-primary-mitochondrial-dysfunction-in-parkinson-s-disease
#12
REVIEW
Maria Pia Giannoccaro, Chiara La Morgia, Giovanni Rizzo, Valerio Carelli
In 1979, it was observed that parkinsonism could be induced by a toxin inhibiting mitochondrial respiratory complex I. This initiated the long-standing hypothesis that mitochondrial dysfunction may play a key role in the pathogenesis of Parkinson's disease (PD). This hypothesis evolved, with accumulating evidence pointing to complex I dysfunction, which could be caused by environmental or genetic factors. Attention was focused on the mitochondrial DNA, considering the occurrence of mutations, polymorphic haplogroup-specific variants, and defective mitochondrial DNA maintenance with the accumulation of multiple deletions and a reduction of copy number...
March 2, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28233933/gaps-and-controversies-in-movement-disorders-introduction-to-the-series
#13
EDITORIAL
Roberto Erro, Alberto J Espay
No abstract text is available yet for this article.
February 24, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28233916/iron-accumulation-and-dysregulation-in-the-putamen-in-fragile-x-associated-tremor-ataxia-syndrome
#14
Jeanelle Ariza, Hailee Rogers, Anna Hartvigsen, Melissa Snell, Michael Dill, Derek Judd, Paul Hagerman, Verónica Martínez-Cerdeño
BACKGROUND: Fragile X-associated tremor/ataxia syndrome is an adult-onset disorder associated with premutation alleles of the FMR1 gene. This disorder is characterized by progressive action tremor, gait ataxia, and cognitive decline. Fragile X-associated tremor/ataxia syndrome pathology includes dystrophic white matter and intranuclear inclusions in neurons and astrocytes. We previously demonstrated that the transport of iron into the brain is altered in fragile X-associated tremor/ataxia syndrome; therefore, we also expect an alteration of iron metabolism in brain areas related to motor control...
February 24, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28218419/alpha-synuclein-fibrils-propagate-through-tunneling-nanotubes
#15
Shinya Okuda, Norihito Uemura, Ryosuke Takahashi
No abstract text is available yet for this article.
February 20, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28218418/thalamic-deep-brain-stimulation-and-gait-in-orthostatic-tremor
#16
LETTER
Aristide Merola, Andrew P Duker, George Mandybur, Tamour Khan Tareen, Jasmine Tuazon, Alberto J Espay, Alfonso Fasano
No abstract text is available yet for this article.
February 20, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28218417/kmt2b-a-new-twist-in-dystonia-genetics-chronic-adbs
#17
Bettina Balint, Enza Maria Valente
No abstract text is available yet for this article.
February 20, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28218416/physiology-of-midbrain-head-movement-neurons-in-cervical-dystonia
#18
Alexey Sedov, Valentin Popov, Vladimir Shabalov, Svetlana Raeva, H A Jinnah, Aasef G Shaikh
BACKGROUND: Early theories for cervical dystonia, as promoted by Hassler, emphasized the role of the midbrain interstitial nucleus of Cajal. Focus then shifted to the basal ganglia, and it was further supported with the success of deep brain stimulation. Contemporary theories suggested the role of the cerebellum, but even more recent hypotheses renewed interest in the midbrain. Although the pretectum was visited on several occasions, we still do not know about the physiology of midbrain neurons in cervical dystonia...
February 20, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28218415/reduced-penetrance-of-leucine-rich-repeat-kinase-2-mutations-discovering-genetic-factors-of-endogenous-disease-protection
#19
Alexander Balck, Christine Klein
No abstract text is available yet for this article.
February 20, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28218413/minimal-clinically-important-differences-for-the-experiences-of-daily-living-parts-of-movement-disorder-society-sponsored-unified-parkinson-s-disease-rating-scale
#20
Krisztina Horváth, Zsuzsanna Aschermann, Márton Kovács, Attila Makkos, Márk Harmat, József Janszky, Sámuel Komoly, Kázmér Karádi, Norbert Kovács
BACKGROUND: The minimal clinically important difference is the smallest change of scores clinically meaningful to patients. OBJECTIVES: We aimed to calculate these threshold values in association with the International Parkinson and Movement Disorder Society UPDRS (MDS-UPDRS) Parts I and II and to evaluate the feasibility of the composite score of Part I and II (MDS-UPDRS I+II) as an outcome. METHODS: Nine hundred eighty-five paired investigations of 365 patients were reviewed, implementing three different techniques simultaneously...
February 20, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
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