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Movement Disorders: Official Journal of the Movement Disorder Society

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https://www.readbyqxmd.com/read/29322595/identification-of-new-%C3%AE-synuclein-regulator-by-nontraditional-drug-development-pipeline
#1
Xi Chen, Sonja W Scholz
No abstract text is available yet for this article.
January 11, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29322556/relationships-between-lewy-and-tau-pathologies-in-375-consecutive-non-alzheimer-s-olfactory-bulbs
#2
Koji Kasanuki, Owen A Ross, Michael A DeTure, Ronald L Walton, Monica Sanchez-Contreras, Shunsuke Koga, Melissa E Murray, Rosa Rademakers, Dennis W Dickson
No abstract text is available yet for this article.
January 11, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29322548/validation-study-of-the-hoehn-and-yahr-scale-included-in-the-mds-updrs
#3
Pablo Martinez-Martin, Matej Skorvanek, Jose Manuel Rojo-Abuin, Zuzana Gregova, Glenn T Stebbins, Christopher G Goetz
No abstract text is available yet for this article.
January 11, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29318639/interaction-between-caffeine-and-polymorphisms-of-glutamate-ionotropic-receptor-nmda-type-subunit-2a-grin2a-and-cytochrome-p450-1a2-cyp1a2-on-parkinson-s-disease-risk
#4
Iris Y Kim, Éilis J O'Reilly, Katherine C Hughes, Xiang Gao, Michael A Schwarzschild, Marjorie L McCullough, Marian T Hannan, Rebecca A Betensky, Alberto Ascherio
BACKGROUND: Caffeine intake has been inversely associated with Parkinson's disease (PD) risk. This relationship may be modified by polymorphisms of glutamate ionotropic receptor NMDA type subunit 2A (GRIN2A) and cytochrome P450 1A2 (CYP1A2), but the results of previous studies have been inconsistent. METHOD: We examined the interaction of caffeine intake with GRIN2A-rs4998386 and CYP1A2-rs762551 polymorphisms in influencing PD risk among 829 incident cases of PD and 2,754 matched controls selected among participants in the following 3 large prospective ongoing cohorts: the Nurses' Health Study, the Health Professionals' Follow-up Study, and the Cancer Prevention Study II Nutrition Cohort...
January 10, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29315826/the-importance-of-cholesterol-in-parkinson-s-disease
#5
LETTER
Patricia García-Sanz, Rosario Moratalla
No abstract text is available yet for this article.
January 9, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29315801/the-emerging-role-of-rab-gtpases-in-the-pathogenesis-of-parkinson-s-disease
#6
REVIEW
Yujing Gao, Gabrielle R Wilson, Sarah E M Stephenson, Kiymet Bozaoglu, Matthew J Farrer, Paul J Lockhart
The identification of pathogenic mutations in Ras analog in brain 39B (RAB39B) and Ras analog in brain 32 (RAB32) that cause Parkinson's disease (PD) has highlighted the emerging role of protein trafficking in disease pathogenesis. Ras analog in brain (Rab) Guanosine triphosphatase (GTPase) function as master regulators of membrane trafficking, including vesicle formation, movement along cytoskeletal networks, and membrane fusion. Recent studies have linked Rab GTPases with α-synuclein, Leucine-rich repeat kinase 2, and Vacuolar protein sorting 35, 3 key proteins in PD pathogenesis...
January 9, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29297596/neuropathology-of-autonomic-dysfunction-in-synucleinopathies
#7
REVIEW
Elizabeth A Coon, Jeremy K Cutsforth-Gregory, Eduardo E Benarroch
The synucleinopathies-Parkinson's disease, dementia with Lewy bodies, multiple system atrophy, and pure autonomic failure-result from distinct patterns of abnormal α-synuclein aggregation throughout the nervous system. Autonomic dysfunction in these disorders results from variable involvement of the central and peripheral autonomic networks. The major pathologic hallmark of Parkinson's disease and dementia with Lewy bodies is Lewy bodies and Lewy neurites; of multiple system atrophy, oligodendroglial cytoplasmic inclusions; and of pure autonomic failure, peripheral neuronal cytoplasmic inclusions...
January 3, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29297592/selected-health-and-lifestyle-factors-cytosine-adenine-guanine-status-and-phenoconversion-in-huntington-s-disease
#8
Caroline Tanner, Karen Marder, Shirley Eberly, Kevin Biglan, David Oakes, Ira Shoulson
BACKGROUND: In Huntington's disease, 60% of the variance in onset age is not explained by the huntingtin gene mutation. Huntington's disease onset was earlier in caffeine users. OBJECTIVE: The objective of this study was to assess the relationship of lifestyle factors with motor phenoconversion among persons at risk for Huntington's disease. METHODS: The associations of motor phenoconversion and exposure to selected lifestyle and health factors were examined using Cox proportional hazards analyses adjusted for age, gender, and repeat length...
January 3, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29278291/rating-scales-for-cognition-in-huntington-s-disease-critique-and-recommendations
#9
REVIEW
Tiago A Mestre, Anne-Catherine Bachoud-Lévi, Johan Marinus, Julie C Stout, Jane S Paulsen, Peter Como, Kevin Duff, Cristina Sampaio, Christopher G Goetz, Esther Cubo, Glenn T Stebbins, Pablo Martinez-Martin
Cognitive impairment is one of the main features of Huntington's disease and is present across the disease spectrum. As part of the International Parkinson's Disease and Movement Disorder Society-sponsored project to review all clinical rating scales used in Huntington's disease, a systematic review of the literature was performed to identify cognitive scales used in Huntington's disease and make recommendations for their use. A total of 17 cognitive scales were identified and evaluated. None of the scales met criteria for a "recommended" status...
December 26, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29278288/tics-and-tourette-syndrome-surplus-of-actions-rather-than-disorder
#10
Christian Beste, Alexander Münchau
No abstract text is available yet for this article.
December 26, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29278286/autonomic-dysfunction-in-parkinson-s-disease-a-prospective-cohort-study
#11
Aristide Merola, Alberto Romagnolo, Michela Rosso, Ritika Suri, Zoe Berndt, Simona Maule, Leonardo Lopiano, Alberto J Espay
BACKGROUND: Dysautonomia is a frequent and disabling complication of PD, with an estimated prevalence of 30-40% and a significant impact on the quality of life. OBJECTIVES: To evaluate the rate of progression of dysautonomia and, in particular, orthostatic hypotension, in a cohort of unselected PD patients, and assess the extent to which the progression of dysautonomia affects activities of daily living, health-related quality of life, and health care utilization in PD...
December 26, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29278279/a-randomized-double-blind-placebo-controlled-trial-of-camicinal-in-parkinson-s-disease
#12
Sarah L Marrinan, Tal Otiker, Lakshmi S Vasist, Rachel A Gibson, Bhopinder K Sarai, Matthew E Barton, Duncan B Richards, Per M Hellström, Dag Nyholm, George E Dukes, David J Burn
BACKGROUND: Delayed gastric emptying may impair l-dopa absorption, contributing to motor fluctuations. We evaluated the effect of camicinal (GSK962040), a gastroprokinetic, on the absorption of l-dopa and symptoms of PD. METHODS: Phase II, double-blind, placebo-controlled trial. Participants were randomized to receive camicinal 50 mg once-daily (n = 38) or placebo (n = 20) for 7 to 9 days. RESULTS: l-dopa exposure was similar with coadministration of camicinal compared to placebo...
December 26, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29278275/prevalence-of-and-indications-for-antipsychotic-use-in-parkinson-s-disease
#13
James H Bower, Brandon R Grossardt, Walter A Rocca, Rodolfo Savica
BACKGROUND: The prevalence of patients with PD taking antipsychotics is unknown. OBJECTIVE: To measure the prevalence of patients with PD taking antipsychotics. METHODS: We used the medical records-linkage system of the Rochester Epidemiology Project to study the use of antipsychotic medication in all persons with Parkinson disease in Olmsted County, Minnesota on 1 January 2006. RESULTS: There were 296 patients with PD in Olmsted County on 1 January 2006...
December 26, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29278274/the-tau-positron-emission-tomography-tracer-av-1451-binds-with-similar-affinities-to-tau-fibrils-and-monoamine-oxidases
#14
Céline Vermeiren, Philippe Motte, Delphine Viot, Georges Mairet-Coello, Jean-Philippe Courade, Martin Citron, Joël Mercier, Jonas Hannestad, Michel Gillard
BACKGROUND: Lilly/Avid's AV-1451 is one of the most advanced tau PET tracers in the clinic. Although results obtained in Alzheimer's disease patients are compelling, discrimination of tracer uptake in healthy individuals and patients with supranuclear palsy (PSP) is less clear as there is substantial overlap of signal in multiple brain regions. Moreover, accurate quantification of [18 F]AV-1451 uptake in Alzheimer's disease may not be possible. OBJECTIVES: The aim of the present study was to characterize the in vitro binding of AV-1451 to understand and identify potential off-target binding that could explain the poor discrimination observed in PSP patients...
December 26, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29272067/what-is-essential-about-essential-tremor-a-diagnostic-placeholder
#15
Alfonso Fasano, Anthony E Lang, Alberto J Espay
No abstract text is available yet for this article.
December 22, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29266403/new-twist-defines-a-spectrum-of-tor1a-neurological-disease
#16
Ana Cascalho, Rose E Goodchild
No abstract text is available yet for this article.
December 21, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29266392/short-pulse-width-in-subthalamic-stimulation-in-parkinson-s-disease-a-randomized-double-blind-study
#17
Walid Bouthour, Jennifer Wegrzyk, Shahan Momjian, Julie Péron, Vanessa Fleury, Emilie Tomkova Chaoui, Judit Horvath, Colette Boëx, Christian Lüscher, Pierre R Burkhard, Paul Krack, André Zacharia
BACKGROUND: We investigated the acute effect of short pulse widths on the therapeutic window in subthalamic nucleus deep brain stimulation in Parkinson's disease. METHODS: We assessed 10 PD patients with STN-DBS at a 60-µs pulse width. We randomly and double-blindedly applied 10- to 50-µs pulse widths. The principal outcome was the therapeutic window (difference between the amplitude thresholds for visible muscle contraction and for best rigidity control). The secondary outcome was the charge per pulse (which reflects the efficiency of the stimulation) needed to control rigidity...
December 21, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29265552/leucine-rich-repeat-kinase-knockout-lrrk-ko-mouse-model-linking-pathological-hallmarks-of-inherited-and-sporadic-parkinson-s-disease
#18
Dorien A Roosen, Andrew B Singleton
No abstract text is available yet for this article.
December 19, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29239027/reply-the-iron-deficient-rat-as-a-model-of-restless-legs-syndrome-was-anything-lost-in-translation
#19
LETTER
Yuan-Yang Lai, Yu-Hsuan Cheng, Kung-Chiao Hsieh, Darian Nguyen, Keng-Tee Chew, Lalini Ramanathan, Jerome M Siegel
No abstract text is available yet for this article.
December 14, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29239020/successful-treatment-of-task-specific-lower-extremity-dystonia-by-ventro-oral-thalamotomy
#20
Shiro Horisawa, Kotaro Kohara, Takakazu Kawamata, Takaomi Taira
No abstract text is available yet for this article.
December 14, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
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