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Movement Disorders: Official Journal of the Movement Disorder Society

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https://www.readbyqxmd.com/read/28737237/subcortical-shape-analysis-of-progressive-mild-cognitive-impairment-in-parkinson-s-disease
#1
Su Jin Chung, Jeong-Hyeon Shin, Kyoo Ho Cho, Yoonju Lee, Young H Sohn, Joon-Kyung Seong, Phil Hyu Lee
BACKGROUND: Cortical neural correlates of ongoing cognitive decline in Parkinson's disease (PD) have been suggested; however, the role of subcortical structures in longitudinal change of cognitive dysfunction in PD has not been fully investigated. Here, we used automatic analysis to explore subcortical brain structures in patients with PD with mild cognitive impairment that converts into PD with dementia. METHODS: One hundred eighty-two patients with PD with mild cognitive impairment were classified as PD with mild cognitive impairment converters (n = 74) or nonconverters (n = 108), depending on whether they were subsequently diagnosed with dementia in PD...
July 24, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28737225/psychostimulant-effect-of-dopaminergic-treatment-and-addictions-in-parkinson-s-disease
#2
Benoit Delpont, Eugénie Lhommée, Hélène Klinger, Emmanuelle Schmitt, Amélie Bichon, Valérie Fraix, Anna Castrioto, Jean-Louis Quesada, Pierre Pélissier, Andrea Kistner, Sébastien Carnicella, Christian Lüscher, Emmanuel Broussolle, Pierre Pollak, Stéphane Thobois, Paul Krack
BACKGROUND: Dopamine replacement therapy in PD has been associated with both behavioral addictions and dopamine addiction. OBJECTIVES: To investigate potential association between l-dopa induced neuropsychiatric fluctuations and addictions in PD. METHODS: A cohort of 102 patients with PD suffering from motor complications of l-dopa treatment was prospectively analyzed. We evaluated dopamine addiction, behavioral addictions, and neuropsychiatric fluctuations using the Ardouin scale of behavior in PD...
July 24, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28736850/progressive-ataxia-and-palatal-tremor-two-autopsy-cases-of-a-novel-tauopathy
#3
Andrew F Gao, Achinoam Faust-Socher, Maryam Al-Murshed, Marc R Del Bigio, Anthony E Lang, David G Munoz
BACKGROUND: Sporadic progressive ataxia and palatal tremor is a rare syndrome characterized by mid- to late-adult-onset symptomatic palatal tremor and slowly progressive cerebellar ataxia. To date, there has been only one autopsy report, which described a novel 4-repeat tauopathy with hypertrophic olivary degeneration and tau-positive inclusions in olivary neurons and dystrophic neuritic processes termed glomeruloid bodies. We report on 2 additional autopsy cases. METHODS: Sections from selected paraffin-embedded brain regions were stained with hematoxylin and eosin/Luxol fast blue and processed for phosphorylated tau, 3-repeat tau, 4-repeat tau, neurofilament, glial fibrillary acid protein, phosphorylated α-synuclein, phosphorylated TAR DNA-binding protein 43, beta-amyloid, and p62 immunohistochemistry...
July 24, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28734065/fdg-pet-dopamine-transporter-spect-and-olfaction-combining-biomarkers-in-rem-sleep-behavior-disorder
#4
Sanne K Meles, David Vadasz, Remco J Renken, Elisabeth Sittig-Wiegand, Geert Mayer, Candan Depboylu, Kathrin Reetz, Sebastiaan Overeem, Angelique Pijpers, Fransje E Reesink, Teus van Laar, Lisette Heinen, Laura K Teune, Helmut Höffken, Marcus Luster, Karl Kesper, Sofie M Adriaanse, Jan Booij, Klaus L Leenders, Wolfgang H Oertel
BACKGROUND: Idiopathic REM sleep behavior disorder is a prodromal stage of Parkinson's disease and dementia with Lewy bodies. Hyposmia, reduced dopamine transporter binding, and expression of the brain metabolic PD-related pattern were each associated with increased risk of conversion to PD. The objective of this study was to study the relationship between the PD-related pattern, dopamine transporter binding, and olfaction in idiopathic REM sleep behavior disorder. METHODS: In this cross-sectional study, 21 idiopathic REM sleep behavior disorder subjects underwent (18) F-fluorodeoxyglucose PET, dopamine transporter imaging, and olfactory testing...
July 22, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28734055/comment-on-shaking-palsy-article
#5
EDITORIAL
Oscar S Gershanik
No abstract text is available yet for this article.
July 22, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28734052/a-deeply-superficial-brain-stimulation
#6
Walid Bouthour, Paul Krack, Christian Lüscher
No abstract text is available yet for this article.
July 22, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28734051/a-user-s-guide-for-%C3%AE-synuclein-biomarker-studies-in-biological-fluids-perianalytical-considerations
#7
REVIEW
Brit Mollenhauer, Richard Batrla, Omar El-Agnaf, Douglas R Galasko, Hilal A Lashuel, Kalpana M Merchant, Lesley M Shaw, Dennis J Selkoe, Robert Umek, Hugo Vanderstichele, Henrik Zetterberg, Jing Zhang, Chelsea Caspell-Garcia, Chris Coffey, Samantha J Hutten, Mark Frasier, Peggy Taylor
Parkinson's disease biomarkers are needed to increase diagnostic accuracy, to objectively monitor disease progression and to assess therapeutic efficacy as well as target engagement when evaluating novel drug and therapeutic strategies. This article summarizes perianalytical considerations for biomarker studies (based on immunoassays) in Parkinson's disease, with emphasis on quantifying total α-synuclein protein in biological fluids. Current knowledge and pitfalls are discussed, and selected perianalytical variables are presented systematically, including different temperature of sample collection and types of collection tubes, gradient sampling, the addition of detergent, aliquot volume, the freezing time, and the different thawing methods...
July 22, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28714593/free-water-improves-detection-of-changes-in-the-substantia-nigra-in-parkinsonism-a-multisite-study
#8
Edward Ofori, Florian Krismer, Roxana G Burciu, Ofer Pasternak, Johanna L McCracken, Mechelle M Lewis, Guangwei Du, Nikolaus R McFarland, Michael S Okun, Werner Poewe, Christoph Mueller, Elke R Gizewski, Michael Schocke, Christian Kremser, Hong Li, Xuemei Huang, Klaus Seppi, David E Vaillancourt
BACKGROUND: Imaging markers that are sensitive to parkinsonism across multiple sites are critically needed for clinical trials. The objective of this study was to evaluate changes in the substantia nigra using single- and bi-tensor models of diffusion magnetic resonance imaging in PD, MSA, and PSP. METHODS: The study cohort (n = 425) included 107 healthy controls and 184 PD, 63 MSA, and 71 PSP patients from 3 movement disorder centers. Bi-tensor free water, free-water-corrected fractional anisotropy, free-water-corrected mean diffusivity, single-tensor fractional anisotropy, and single-tensor mean diffusivity were computed for the anterior and posterior substantia nigra...
July 17, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28714579/history-of-the-foundation-looking-after-patient-needs-and-promoting-research-how-can-patients-charities-and-researchers-move-together-toward-resolving-pd
#9
John L Lehr
No abstract text is available yet for this article.
July 17, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28686320/the-emerging-science-of-precision-medicine-and-pharmacogenomics-for-parkinson-s-disease
#10
Haydeh Payami
Current therapies for Parkinson's disease are problematic because they are symptomatic and have adverse effects. New drugs have failed in clinical trials because of inadequate efficacy. At the core of the problem is trying to make one drug work for all Parkinson's disease patients, when we know this premise is wrong because (1) Parkinson's disease is not a single disease, and (2) no two individuals have the same biological makeup. Precision medicine is the goal to strive for, but we are only at the beginning stages of building the infrastructure for one of the most complex projects in the history of science, and it will be a long time before Parkinson's disease reaps the benefits...
July 7, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28686318/pathophysiological-heterogeneity-in-parkinson-s-disease-neurophysiological-insights-from-lrrk2-mutations
#11
LETTER
Maja Kojovic, Pangiotis Kassavetis, Isabel Pareés, Dejan Georgiev, Lorenzo Rocchi, Betina Balint, Tom Foltynie, John Rothwell, Kailash Bhatia
No abstract text is available yet for this article.
July 7, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28686310/neuromelanin-magnetic-resonance-imaging-of-the-substantia-nigra-in-lrrk2-related-parkinson-s-disease
#12
LETTER
Leonor Correia Guedes, Sofia Reimão, Patrícia Paulino, Rita G Nunes, Raquel Bouça-Machado, Daisy Abreu, Nilza Gonçalves, Tiago Soares, Margherita Fabbri, Catarina Godinho, Patrícia Pita Lobo, Dulce Neutel, Marialuisa Quadri, Miguel Coelho, Mario M Rosa, Jorge Campos, Tiago F Outeiro, Cristina Sampaio, Vincenzo Bonifati, Joaquim J Ferreira
No abstract text is available yet for this article.
July 7, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28681985/progression-markers-of-motor-deficits-in-parkinson-s-disease-a-biannual-4-year-prospective-study
#13
LETTER
Sebastian Heinzel, Felix P Bernhard, Benjamin Roeben, Susanne Nussbaum, Tanja Heger, Peter Martus, Markus A Hobert, Walter Maetzler, Daniela Berg
No abstract text is available yet for this article.
July 6, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28681957/parkinson-disease-and-clathrin-coat-dynamics-at-synapses-why-not
#14
Sara Saez-Atienzar, Andrew B Singleton
No abstract text is available yet for this article.
July 6, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28681931/assessments-of-plasma-ghrelin-levels-in-the-early-stages-of-parkinson-s-disease
#15
Ning Song, Weiwei Wang, Fengjv Jia, Xixun Du, Anmu Xie, Qing He, Xiaoli Shen, Jing Zhang, Jack T Rogers, Junxia Xie, Hong Jiang
BACKGROUND: Gastrointestinal symptoms are early events in Parkinson's disease (PD). The gastrointestinal hormone ghrelin was neuroprotective in the nigrostriatal dopamine system. The objective of this study was to assess ghrelin levels in the early stages of PD. METHODS: Plasma was collected in the fasting state in 291 PD patients in stages 1-3 and 303 age- and sex-matched healthy controls. Additional samples were taken in the glucose response test to assess nutrition-related ghrelin levels in 20 PD patients and 20 healthy controls...
July 6, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28681922/spinal-cord-stimulation-in-primary-progressive-freezing-of-gait
#16
REVIEW
Mohammad Rohani, Sukhvinder Kalsi-Ryan, Andres M Lozano, Alfonso Fasano
No abstract text is available yet for this article.
July 6, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28671311/cognitive-impairment-in-multiple-system-atrophy
#17
REVIEW
Eleonora Fiorenzato, Angelo Antonini, Gregor Wenning, Roberta Biundo
No abstract text is available yet for this article.
July 3, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28671292/reply-re-profile-of-cognitive-impairment-and-underlying-pathology-in-multiple-system-atrophy
#18
REVIEW
Shunsuke Koga, Adam Parks, Dennis W Dickson
No abstract text is available yet for this article.
July 3, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28657124/large-pd-examining-the-genetics-of-parkinson-s-disease-in-latin-america
#19
LETTER
Cyrus P Zabetian, Ignacio F Mata
No abstract text is available yet for this article.
June 28, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28646494/topiramate-as-an-adjunct-to-amantadine-in-the-treatment-of-dyskinesia-in-parkinson-s-disease-a-randomized-double-blind-placebo-controlled-multicenter-study
#20
Christopher G Goetz, Glenn T Stebbins, Kathryn A Chung, Anthony P Nicholas, Robert A Hauser, Douglas Merkitch, Mark A Stacy
No abstract text is available yet for this article.
June 24, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
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