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Movement Disorders: Official Journal of the Movement Disorder Society

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https://www.readbyqxmd.com/read/28631864/ceftriaxone-reduces-l-dopa-induced-dyskinesia-severity-in-6-hydroxydopamine-parkinson-s-disease-model
#1
Tanya Chotibut, Samantha Meadows, Ella A Kasanga, Tamara McInnis, Mark A Cantu, Christopher Bishop, Michael F Salvatore
BACKGROUND: Increased extracellular glutamate may contribute to l-dopa induced dyskinesia, a debilitating side effect faced by Parkinson's disease patients 5 to 10 years after l-dopa treatment. Therapeutic strategies targeting postsynaptic glutamate receptors to mitigate dyskinesia may have limited success because of significant side effects. Increasing glutamate uptake may be another approach to attenuate excess glutamatergic neurotransmission to mitigate dyskinesia severity or prolong the time prior to onset...
June 20, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28631862/thalamic-deep-brain-stimulation-for-orthostatic-tremor-a-multicenter-international-registry
#2
Aristide Merola, Alfonso Fasano, Anhar Hassan, Jill L Ostrem, Maria Fiorella Contarino, Mark Lyons, Joachim K Krauss, Marc E Wolf, Bryan T Klassen, Anne-Fleur van Rootselaar, Ignacio Regidor, Andrew P Duker, William Ondo, Jorge Guridi, Jens Volkmann, Aparna Wagle Shukla, George T Mandybur, Michael S Okun, Karsten Witt, Philip A Starr, Günther Deuschl, Alberto J Espay
BACKGROUND: We report the accumulated experience with ventral intermediate nucleus deep brain stimulation for medically refractory orthostatic tremor. METHODS: Data from 17 patients were reviewed, comparing presurgical, short-term (0-48 months), and long-term (≥48 months) follow-up. The primary end point was the composite activities of daily living/instrumental activities of daily living score. Secondary end points included latency of symptoms on standing and treatment-related complications...
June 20, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28631854/make-dopamine-neurons-great-again-an-exciting-new-therapeutic-option-in-parkinson-s-disease
#3
REVIEW
Luis Bonet-Ponce, Andrew B Singleton
No abstract text is available yet for this article.
June 20, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28627133/mesocorticolimbic-hemodynamic-response-in-parkinson-s-disease-patients-with-compulsive-behaviors
#4
Daniel O Claassen, Adam J Stark, Charis A Spears, Kalen J Petersen, Nelleke C van Wouwe, Robert M Kessler, David H Zald, Manus J Donahue
BACKGROUND: PD patients treated with dopamine therapy can develop maladaptive impulsive and compulsive behaviors, manifesting as repetitive participation in reward-driven activities. This behavioral phenotype implicates aberrant mesocorticolimbic network function, a concept supported by past literature. However, no study has investigated the acute hemodynamic response to dopamine agonists in this subpopulation. OBJECTIVES: We tested the hypothesis that dopamine agonists differentially alter mesocortical and mesolimbic network activity in patients with impulsive-compulsive behaviors...
June 19, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28627117/the-cognitive-features-of-idiopathic-and-dyt1-dystonia
#5
REVIEW
Marjan Jahanshahi, Mariam Torkamani
Dystonia is a common movement disorder. In this paper, we review the literature on cognitive function in idiopathic and DYT1 dystonia. In idiopathic or DYT1 dystonia, cognition is largely intact with only isolated executive dysfunction. Dystonia patients also have increased temporal and spatial discrimination thresholds, considered endophenotypes of the disorder because deficits are also shown by unaffected relatives and nonmanifesting carriers of the DYT1 mutation. Anticholinergic medication in high doses can be associated with memory impairment in dystonia...
June 19, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28621014/cell-specific-%C3%AE-amino-3-hydroxy-5-methyl-4-isoxazolepropionic-acid-receptor-antagonism-reveals-new-insights-in-the-development-of-parkinson-s-disease
#6
REVIEW
Assunta Pelosi
No abstract text is available yet for this article.
June 16, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28620963/skeletal-muscle-characteristics-and-mitochondrial-function-in-huntington-s-disease-patients
#7
LETTER
Saskia Maria Gehrig, Jens A Petersen, Sebastian Frese, Sandro Manuel Mueller, Violeta Mihaylova, Maria Ligon-Auer, Carsten Lundby, Marco Toigo, Hans H Jung
No abstract text is available yet for this article.
June 16, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28620961/normal-atxn2-alleles-influences-on-the-age-at-onset-in-spinocerebellar-ataxia-type-2
#8
REVIEW
Luis E Almaguer-Mederos, Raúl Aguilera-Rodríguez, Dany Cuello-Almarales, Dennis Almaguer-Gotay, Yanetza González-Zaldívar, Yaimé Vázquez-Mojena, Nieves Santos-Falcón, Gilberto Sánchez-Cruz, Luis Velázquez-Pérez
No abstract text is available yet for this article.
June 16, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28612949/drug-induced-parkinsonism
#9
LETTER
Joseph H Friedman
No abstract text is available yet for this article.
June 14, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28612948/to-lesion-or-not-to-lesion-that-was-the-question-reply-to-mds-17-0217
#10
Jose A Obeso, Raul Martinez-Fernandez, Marta Del Álamo, Paul Krack
No abstract text is available yet for this article.
June 14, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28612947/stereotactic-ablative-surgery-does-not-just-mean-adding-another-lesion
#11
Marwan Hariz
No abstract text is available yet for this article.
June 14, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28612941/response-to-letter-by-friedman-on-incidence-and-time-trends-of-drug-induced-parkinsonism-a-30-year-population-based-study
#12
LETTER
Walter A Rocca, Rodolfo Savica, Brandon R Grossardt
No abstract text is available yet for this article.
June 14, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28605056/mild-cognitive-impairment-as-a-risk-factor-for-parkinson-s-disease-dementia
#13
Jeroen Hoogland, Judith A Boel, Rob M A de Bie, Ronald B Geskus, Ben A Schmand, John C Dalrymple-Alford, Connie Marras, Charles H Adler, Jennifer G Goldman, Alexander I Tröster, David J Burn, Irene Litvan, Gert J Geurtsen
BACKGROUND: The International Parkinson and Movement Disorder Society criteria for mild cognitive impairment in PD were recently formulated. OBJECTIVES: The aim of this international study was to evaluate the predictive validity of the comprehensive (level II) version of these criteria by assessment of their contribution to the hazard of PD dementia. METHODS: Individual patient data were selected from four separate studies on cognition in PD that provided information on demographics, motor examination, depression, neuropsychological examination suitable for application of level II criteria, and longitudinal follow-up for conversion to dementia...
June 12, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28605054/personalized-medicine-in-parkinson-s-disease-time-to-be-precise
#14
Nataliya Titova, K Ray Chaudhuri
No abstract text is available yet for this article.
June 12, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28594134/many-genes-involved-in-tourette-syndrome-pathogenesis
#15
Roger L Albin
No abstract text is available yet for this article.
June 8, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28594127/no-clear-support-for-a-role-for-vitamin-d-in-parkinson-s-disease-a-mendelian-randomization-study
#16
Susanna C Larsson, Andrew B Singleton, Mike A Nalls, J Brent Richards
BACKGROUND: Observational studies have found that relative to healthy controls, patients with Parkinson's disease have lower circulating concentrations of 25-hydroxyvitamin D, a clinical biomarker of vitamin D status. However, the causality of this association is uncertain. We undertook a Mendelian randomization study to investigate whether genetically decreased 25-hydroxyvitamin D concentrations are associated with PD to minimize confounding and prevent bias because of reverse causation...
June 8, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28590580/projection-of-the-prevalence-of-parkinson-s-disease-in-the-coming-decades-revisited
#17
Alexander Rossi, Kristin Berger, Honglei Chen, Douglas Leslie, Richard B Mailman, Xuemei Huang
OBJECTIVE: Previous studies have estimated future PD prevalence based on population aging. This study revisits that projection by accounting for the potential impact of declining rates of smoking. METHODS: The age- and gender-stratified smoking prevalence in the United States from 2000 to 2040 were obtained from the U.S. Census Bureau and the U.S. Surgeon General's Smoking Report. PD prevalence was estimated based on population aging with and without an account of the impact of declining smoking rates...
June 7, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28590575/reply-to-mri-measures-of-brainstem-in-parkinsonian-syndromes-where-we-stand-and-where-we-need-to-go
#18
LETTER
Jan Kassubek, Hans-Jürgen Huppertz, Günter U Höglinger
No abstract text is available yet for this article.
June 7, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28590561/reprogramming-the-striatal-stars-a-new-treatment-option-for-parkinson-s-disease
#19
Arvind Kumar
No abstract text is available yet for this article.
June 7, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28590521/seventy-years-with-the-globus-pallidus-pallidal-surgery-for-movement-disorders-between-1947-and-2017
#20
REVIEW
Laura Cif, Marwan Hariz
The year 2017 marks the 70th anniversary of the birth of human stereotactic neurosurgery. The first procedure was a pallidotomy for Huntington's disease. However, it was for Parkinson's disease that pallidotomy was soon adopted worldwide. Pallidotomy was abandoned in the late 1950s in favor of thalamotomy because of the latter's more striking effect on tremor. The advent of levodopa put a halt to all surgery for PD. In the mid-1980s, Laitinen reintroduced the posteroventral pallidotomy of Leksell, and this procedure spread worldwide thanks to its efficacy on most parkinsonian symptoms including levodopa-induced dyskinesias and thanks to basic scientific work confirming the role of the globus pallidus internus in the pathophysiology of PD...
June 7, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
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