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Movement Disorders: Official Journal of the Movement Disorder Society

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https://www.readbyqxmd.com/read/28429881/have-we-been-overestimating-fall-rates-in-parkinson-s-disease
#1
LETTER
Mélanie L Beaulieu, Martijn L T M Müller, Nicolaas I Bohnen
No abstract text is available yet for this article.
April 21, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28429864/have-we-been-overestimating-fall-rates-in-parkinson-s-disease
#2
LETTER
Sue Lord, Brook Galna, Alison J Yarnall, Shirley Coleman, David Burn, Lynn Rochester
No abstract text is available yet for this article.
April 21, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28429825/validation-of-the-mds-research-criteria-for-prodromal-parkinson-s-disease-longitudinal-assessment-in-a-rem-sleep-behavior-disorder-rbd-cohort
#3
Seyed-Mohammad Fereshtehnejad, Jacques Y Montplaisir, Amelie Pelletier, Jean-François Gagnon, Daniela Berg, Ronald B Postuma
BACKGROUND: Recently, the International Parkinson and Movement Disorder Society introduced the prodromal criteria for PD. Objectives Our study aimed to examine diagnostic accuracy of the criteria as well as the independence of prodromal markers to predict conversion to PD or dementia with Lewy bodies. METHODS: This prospective cohort study was performed on 121 individuals with rapid eye movement sleep behavior disorder who were followed annually for 1 to 12 years...
April 21, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28419651/reply-letter-to-does-motor-cortex-plasticity-depend-on-the-type-of-mutation-in-the-lrrk2-gene
#4
REVIEW
Francesco Di Lorenzo, Viviana Ponzo, Livia Brusa, Carlo Caltagirone, Giacomo Koch
No abstract text is available yet for this article.
April 17, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28419556/does-motor-cortex-plasticity-depend-on-the-type-of-mutation-in-the-leucine-rich-repeat-kinase-2-gene
#5
LETTER
Raffaele Dubbioso, Anna de Rosa, Marcello Esposito, Silvio Peluso, Rosa Iodice, Giuseppe de Michele, Lucio Santoro, Fiore Manganelli
No abstract text is available yet for this article.
April 17, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28394086/exophers-expel-toxic-aggregates-the-new-discovery-of-a-defense-mechanism-against-misfolded-or-toxic-proteins
#6
Amir Tayaranian Marvian, Dina Morshedi
No abstract text is available yet for this article.
April 10, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28394042/metabolic-profiling-of-parkinson-s-disease-and-mild-cognitive-impairment
#7
Florence Burté, David Houghton, Hannah Lowes, Angela Pyle, Sarah Nesbitt, Alison Yarnall, Patrick Yu-Wai-Man, David J Burn, Mauro Santibanez-Koref, Gavin Hudson
BACKGROUND: Early diagnosis of Parkinson's disease and mild cognitive impairment is important to enable prompt treatment and improve patient welfare, yet no standard diagnostic test is available. Metabolomics is a powerful tool used to elucidate disease mechanisms and identify potential biomarkers. OBJECTIVES: The objective of this study was to use metabolic profiling to understand the pathoetiology of Parkinson's disease and to identify potential disease biomarkers...
April 10, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28394032/brain-pet-imaging-of-phosphodiesterase-10a-in-progressive-supranuclear-palsy-and-parkinson-s-disease
#8
LETTER
Michel Koole, Koen Van Laere, Rawaha Ahmad, Jenny Ceccarini, Guy Bormans, Wim Vandenberghe
No abstract text is available yet for this article.
April 10, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28394031/degeneration-of-rapid-eye-movement-sleep-circuitry-underlies-rapid-eye-movement-sleep-behavior-disorder
#9
REVIEW
Dillon McKenna, John Peever
During healthy rapid eye movement sleep, skeletal muscles are actively forced into a state of motor paralysis. However, in rapid eye movement sleep behavior disorder-a relatively common neurological disorder-this natural process is lost. A lack of motor paralysis (atonia) in rapid eye movement sleep behavior disorder allows individuals to actively move, which at times can be excessive and violent. At first glance this may sound harmless, but it is not because rapid eye movement sleep behavior disorder patients frequently injure themselves or the person they sleep with...
April 10, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28394027/changes-in-the-cell-population-in-brain-white-matter-in-multiple-system-atrophy
#10
Charlotte Havelund Nykjaer, Tomasz Brudek, Lisette Salvesen, Bente Pakkenberg
BACKGROUND: Multiple system atrophy (MSA) is a sporadic progressive neurodegenerative disorder with adult onset and unknown etiology. Clinically it is characterized by autonomic failure, cerebellar ataxia, parkinsonism, and corticospinal dysfunction in any combination and with varying severity. OBJECTIVES AND METHODS: To establish the extent of involvement of the white matter in the disease, we have used stereology to quantify the total number of neurons and glial cells (oligodendrocytes, astrocytes, and microglia) in the brains from 10 MSA patients and 11 controls...
April 10, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28394013/intermittent-theta-burst-stimulation-rescues-dopamine-dependent-corticostriatal-synaptic-plasticity-and-motor-behavior-in-experimental-parkinsonism-possible-role-of-glial-activity
#11
Fabrizio Cacace, Desirèe Mineo, Maria Teresa Viscomi, Emanuele Claudio Latagliata, Maria Mancini, Valeria Sasso, Anna Vannelli, Tiziana Pascucci, Valentina Pendolino, Elena Marcello, Silvia Pelucchi, Stefano Puglisi-Allegra, Marco Molinari, Barbara Picconi, Paolo Calabresi, Veronica Ghiglieri
BACKGROUND: Recent studies support the therapeutic utility of repetitive transcranial magnetic stimulation in Parkinson's disease (PD), whose progression is correlated with loss of corticostriatal long-term potentiation and long-term depression. Glial cell activation is also a feature of PD that is gaining increasing attention in the field because astrocytes play a role in chronic neuroinflammatory responses but are also able to manage dopamine (DA) levels. METHODS: Intermittent theta-burst stimulation protocol was applied to study the effect of therapeutic neuromodulation on striatal DA levels measured by means of in vivo microdialysis in 6-hydroxydopamine-hemilesioned rats...
April 10, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28374536/hypothermia-a-serious-adverse-effect-of-piribedil-the-first-human-case-report
#12
LETTER
Anthony Vanjak, Sarah Lechtman, Jean-François Bergmann, Damien Sène, Célia Lloret-Linares
No abstract text is available yet for this article.
April 4, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28370613/sequencing-tmem230-in-chinese-patients-with-sporadic-or-familial-parkinson-s-disease
#13
LETTER
Xinglong Yang, Ran An, Jing Xi, Jinhua Zheng, Yalan Chen, Hongyan Huang, Sijia Tian, Quanzhen Zhao, Pingping Ning, Yanming Xu
No abstract text is available yet for this article.
April 3, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28370445/media-hype-patient-and-scientific-perspectives-on-misleading-medical-news
#14
Israel Robledo, Joseph Jankovic
In this age of digital technology, Internet, and social media we are increasingly subjected to an information and disinformation overload. This includes not only political and economic information but also medical news, which is often presented as a "new discovery", "miracle cure" or some other press hyperbole. In this viewpoint article we present patient and scientific perspectives some recent episodes of medical hype related to Parkinson's disease research, including proposed therapies such as nilotinib, marijuana, stem cells and other controversial therapies that have attracted the mainstream and social media...
April 3, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28370363/who-is-to-blame-medical-hype-in-the-media
#15
EDITORIAL
Julie M Robillard
No abstract text is available yet for this article.
April 3, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28370358/disparate-genes-come-together-spatial-and-genetic-screens-point-to-disruptions-in-vesicle-trafficking-and-mrna-metabolism-in-synucleinopathies
#16
Rachel Underwood, Talene A Yacoubian
No abstract text is available yet for this article.
April 3, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28370340/a-randomized-trial-of-a-low-dose-rasagiline-and-pramipexole-combination-p2b001-in-early-parkinson-s-disease
#17
C Warren Olanow, Karl Kieburtz, Mika Leinonen, Lawrence Elmer, Nir Giladi, Robert A Hauser, Olga S Klepiskaya, David L Kreitzman, Mark F Lew, David S Russell, Shaul Kadosh, Pninit Litman, Hadas Friedman, Nurit Linvah, For The P B Study Group
BACKGROUND: Rasagiline and pramipexole act to improve striatal dopaminergic transmission in PD via distinct and potentially synergistic mechanisms. We performed a placebo-controlled study to determine whether 2 doses of a novel slow-release, low-dose combination of rasagiline and pramipexole (P2B001) are effective and have a good safety profile in patients with early untreated PD. METHODS: Previously untreated patients with early PD were randomized (1:1:1) to once-daily treatment with P2B001 (0...
April 3, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28370314/statins-may-facilitate-parkinson-s-disease-insight-gained-from-a-large-national-claims-database
#18
Guodong Liu, Nicholas W Sterling, Lan Kong, Mechelle M Lewis, Richard B Mailman, Honglei Chen, Douglas Leslie, Xuemei Huang
OBJECTIVE: Using a large U.S. claims database (MarketScan), we investigated the controversy surrounding the role of statins in Parkinson's disease (PD). METHODS: We performed a retrospective case-control analysis. First, we identified 2322 incident PD cases having a minimum of 2.5 years of continuous enrollment prior to earliest diagnosis code or prescription of antiparkinson medication. A total of 2322 controls were then matched individually by age, gender, and a follow-up window to explore the relationship of statin use with incident PD...
April 3, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28370299/evidence-for-dopaminergic-denervation-in-classical-galactosemia
#19
LETTER
Alice Poisson, Emmanuel Roze, Caroline Demily, Stéphane Thobois
No abstract text is available yet for this article.
April 3, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28370272/cost-effectiveness-of-focused-ultrasound-radiosurgery-and-dbs-for-essential-tremor
#20
Vinod K Ravikumar, Jonathon J Parker, Traci S Hornbeck, Veronica E Santini, Kim Butts Pauly, Max Wintermark, Pejman Ghanouni, Sherman C Stein, Casey H Halpern
BACKGROUND: Essential tremor remains a very common yet medically refractory condition. A recent phase 3 study demonstrated that magnetic resonance-guided focused ultrasound thalamotomy significantly improved upper limb tremor. The objectives of this study were to assess this novel therapy's cost-effectiveness compared with existing procedural options. METHODS: Literature searches of magnetic resonance-guided focused ultrasound thalamotomy, DBS, and stereotactic radiosurgery for essential tremor were performed...
April 3, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
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