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Histology and Histopathology

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https://www.readbyqxmd.com/read/28211035/resveratrol-decreases-foxo-protein-expression-through-pi3k-akt-dependent-pathway-inhibition-in-h2o2-treated-synoviocytes
#1
Bin Xu, Gaoyuan Wang, Junqiang Zhang, Wei Cao, Xiaoyu Chen
The aim of this study was to investigate the effects of resveratrol (Res) on hydrogen peroxide (H2O2)-treated fibroblast-like synoviocytes (FLSs) in vitro. We studied the phosphoinositide 3-kinase (PI3K)-Akt pathway inhibition-mediated effects of Res on forkhead box O (FoXO) mRNA expression levels. FLS viability was determined by Cell Counting Kit-8 (CCK-8) assay, and FLS apoptosis was measured by terminal deoxyribo nucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL) staining and flow cytometry...
February 17, 2017: Histology and Histopathology
https://www.readbyqxmd.com/read/28197987/effects-of-frutalin-on-early-follicle-morphology-ultrastructure-and-gene-expression-in-cultured-goat-ovarian-cortical-tissue
#2
Maria A A Soares, José J N Costa, Gisvani L Vasconcelos, Regislane P Ribeiro, José C Souza, André L C Silva, Robert Van den Hurk, José R V Silva
Frutalin is a galactose-binding lectin that has an irreversible cytotoxic effect on HeLa cervical cancer cells, by inducing apoptosis and inhibiting cell proliferation. It was previously shown that after in vitro incubation, frutalin is internalized into HeLa cells nucleus, which indicates that frutalin apoptosis-inducing activity might be linked with its nuclear localization. Considering that drugs commonly used for cancer treatment have a deleterious effect on germ cells, the aim of this study was to evaluate the effect of frutalin on the activation, survival, ultrastructure and gene expression in follicles cultured within ovarian tissue...
February 15, 2017: Histology and Histopathology
https://www.readbyqxmd.com/read/28177105/the-circumventricular-organs
#3
REVIEW
Charanjit Kaur, Eng-Ang Ling
The circumventricular organs (CVOs) are midline structures located around the third and fourth ventricles and are characterized by a lack of blood-brain barrier. The pineal gland, median eminence, neurohypophysis and the subcommisural organ are classified as secretory, whereas the subfornical organ, area postrema and the organum vasculosum of the lamina terminalis are the sensory CVOs. Specialised ependymal cells known as tanycytes form the ependymal of these organs. Glial cells consisting of astrocytes and microglia/macrophages are present in all these organs...
February 8, 2017: Histology and Histopathology
https://www.readbyqxmd.com/read/28155218/expression-profiles-of-angiogenesis-in-two-high-grade-chondrosarcomas-a-xenotransplant-experience-in-nude-mice
#4
Francisco Giner, José Antonio López-Guerrero, Isidro Machado, Zaida García-Casado, Antonio Fernández-Serra, Amando Peydró-Olaya, Antonio Llombart-Bosch
BACKGROUND: Chondrosarcomas (Chs) are malignant cartilage-forming tumors that represent the third most common malignant solid tumor of bone in adults. Angiogenesis is a major factor for tumor growth and metastasis. Our aim was to make a histological, immunohistochemical, ultrastructural and molecular characterization of the neovascularization established between xenotransplanted Chs and the host during the initial phases of growth in nude transfer, in order to find potential markers for distinguishing between high grades II and III Chs...
February 3, 2017: Histology and Histopathology
https://www.readbyqxmd.com/read/28145559/myoepithelial-tumor-of-soft-tissue-and-bone-current-perspective
#5
REVIEW
Anuj Verma, Bharat Rekhi
Myoepithelial tumor (MET) of soft tissue and bone is an unusual tumor of uncertain differentiation and histogenesis, but lately has been recognized as a distinct tumor entity. This tumor forms a morphologic continuum with a mixed tumor and a parachordoma, but is different from an extra-axial chordoma or chordoma periphericium. METs display a range of histopathologic features, including architectural arrangements/growth patterns, cell types and intervening stroma, leading to their several differential diagnoses...
February 1, 2017: Histology and Histopathology
https://www.readbyqxmd.com/read/28134413/the-function-and-significance-of-sera2a-in-congestive-heart-failure-an-analysis-of-gene-therapy-trials
#6
REVIEW
Pei Wu, Yuting Zhai, Dongye Li
Congestive heart failure (CHF) is a widespread disease that has a negative impact on health, worldwide. Despite advances in therapies, morbidity, mortality and hospital discharges due to CHF remain high. Advances in the understanding of the pathophysiological mechanisms of CHF and the development of gene transfer technology have made gene therapy a realistic potential therapeutic method for CHF. Among the various potential targets, sarco-endoplasmic reticulum Ca2+-ATPase 2a (SERCA2a), which is an important protein in the regulation of Ca2+ cycling, has piqued the interest of many researchers...
January 30, 2017: Histology and Histopathology
https://www.readbyqxmd.com/read/28127725/ovarian-leydig-cells-olc-a-histomorphological-and-immunohistochemical-study
#7
J L Carrasco-Juan, H Álvarez-Argüelles Cabrera, M C Martín Corriente, M González-Gómez, R Valladares Parrilla, R Gutiérrez García, L Díaz-Flores
Testicular Leydig cells (LC) regulate the proper development of male individuals, both during fetal life (fetal LC) and puberty (adult LC). In the ovaries of adult women, there are cells that are very similar to Leydig cells, the ovarian hilus cells (OHC), which also produce testosterone. The origin of these cells, in both sexes, remains unknown and is still a matter of debate. We have studied the location, characteristics and relationships of the OHC in 90 patients. The indications for oophorectomy were: metrorrhagia (n=9), prolapse (n=8), endometrial hyperplasia (n=14), cancer (endometrial, myometrial, or cervical) (n=35), uterine leiomyomata (n=14), and various ovarian tumors (cysts and benign tumors, borderline and malignant) (n=10)...
January 27, 2017: Histology and Histopathology
https://www.readbyqxmd.com/read/28124315/relevance-of-in-vitro-3-d-skin-models-in-dissecting-cytokine-contribution-to-psoriasis-pathogenesis
#8
REVIEW
A Chiricozzi, M Romanelli, S Panduri, E Donetti, F Prignano
Psoriasis is a chronic skin disease characterized by the activation of various T cell subsets secreting IFNγ, IL-17, and IL-22, dendritic cells producing TNFα and IFNα, and other immune cells including neutrophils and mast cells. Keratinocytes respond to different cytokine signals orchestrating innate and adaptive immune responses. In vitro studies sought to clarify the cytokine effects on keratinocytes in order to evaluate the centrality of these mediators in psoriasis pathogenesis. The aim of this review is to highlight the relevance of this peculiar in vitro approach in investigating cytokine effects on skin or multilayered epidermis...
January 26, 2017: Histology and Histopathology
https://www.readbyqxmd.com/read/28120327/assessment-of-immunologic-proangiogenic-and-neurogenic-properties-of-human-peripheral-nerve-epineurium-for-potential-clinical-application
#9
Aleksandra Klimczak, Maria Siemionow, Katarzyna Futoma, Arkadiusz Jundzill, Dariusz Patrzalek
The epineural sheath is a promising naturally occurring material for enhancement of peripheral nerve regeneration. Based on a literature search there is a limited number of reports on the biological and immunological properties of human epineurium. The goal of this study was to assess, using immunocytochemical methods, the immunological (HLA class I and II antigens, T lymphocytes, macrophages), proangiogenic (VEGF, CD31), and neurogenic (GFAP, S-100) properties of human epineurium isolated from ilioinguinal nerves (n=19) taken from deceased donors, and from sciatic nerves (n=12) taken from limbs amputated due to critical ischemia...
January 25, 2017: Histology and Histopathology
https://www.readbyqxmd.com/read/28116735/effect-of-estradiol-on-the-expression-of-angiogenic-factors-in-epithelial-ovarian-cancer
#10
Macarena Valladares, Francisca Plaza-Parrochia, Macarena Lépez, Daniela López, Fernando Gabler, Patricio Gayan, Alberto Selman, Margarita Vega, Carmen Romero
INTRODUCTION: Ovarian cancer presents a high angiogenesis (formation of new blood vessels) regulated by pro-angiogenic factors, mainly vascular endothelial growth factor (VEGF) and nerve growth factor (NGF). An association between endogenous levels of estrogen and increased risk of developing ovarian cancer has been reported. Estrogen action is mediated by the binding to its specific receptors (ERα and ERβ), altered ERα/ERβ ratio may constitute a marker of ovarian carcinogenesis progression...
January 24, 2017: Histology and Histopathology
https://www.readbyqxmd.com/read/28111737/expression-of-dna-methylation-related-proteins-in-invasive-lobular-carcinoma-of-breast-comparison-to-invasive-ductal-carcinoma
#11
Yoon Jin Cha, Hye Min Kim, Ja Seung Koo
PURPOSE: We aimed to compare the expression of DNA methylation-related proteins in invasive lobular carcinoma (ILC) of breast with those of invasive ductal carcinoma (IDC) of breast and to assess its potential clinical application. METHODS: Immunohistochemical staining of DNS methylation-related proteins (5-meC, DNMT1, DNMT3B and ISL-1) was applied to tissue microarrays generated from 108 ILCs and 203 IDCs. Protein expression and its correlation with clinicopatholgic variables were statistically analyzed...
January 23, 2017: Histology and Histopathology
https://www.readbyqxmd.com/read/28105630/histopathological-features-of-endometritis-eosinophilica-in-mares
#12
Anna Lena Grimm, Heinz-Adolf Schoon, Sandra Schöniger
Equine endometritis eosinophilica (EE) is rarely described and its diagnostic criteria are not defined. The aim of this study was to characterize histological features of EE. A data base (1995-2013) was searched for biopsies with increased eosinophils. This study included all biopsies with this diagnosis and representative biopsies without this record. The definition of equine EE was based on criteria for EE in women and the results of the determination of physiological numbers of eosinophils within the equine endometrium...
January 20, 2017: Histology and Histopathology
https://www.readbyqxmd.com/read/28101875/sustanon-induces-dose-independent-hypertrophy-and-satellite-cell-proliferation-in-slow-oxidative-fibers-of-avian-skeletal-muscle
#13
Mohammed Z Allouh, Ahmad A Jarrar, Hasan A Asfour, Raed S Said, Emad I Shaqoura
Sustanon is a well-known anabolic drug that is used to treat hypogonadism and restore muscle mass and bone density. As research to date has been limited to its effects in glycolytic fibers, this study aimed to investigate the dose-related effects of Sustanon on the oxidative fibers of avian skeletal muscle. Adult female chickens were randomly divided into 4 groups: control (C), received a dose of 100 μl normal saline per injection; and Sustanon-1, -2, and -3 (S1, S2, and S3), that received a dose of 12.5, 25, or 50 mg/kg Sustanon per injection, respectively...
January 19, 2017: Histology and Histopathology
https://www.readbyqxmd.com/read/28097642/adrenal-cyst-with-both-m%C3%A3-llerian-and-mesothelial-differentiation-a-clinicopathological-and-immunohistochemical-study-with-implications-for-histogenesis
#14
Łukasz Koperski, Benedykt Szczepankiewicz, Paweł Pihowicz, Łukasz Fus, Ewa Wolińska, Barbara Górnicka
True epithelial-lined cysts are rare forms of adrenal cystic lesions, the pathogenesis of which is still not fully understood. In this report we present a case of an adrenal cyst diagnosed incidentally on imaging in a 31-year-old, previously healthy, obese woman. Due to non-specific hormonal disorders and enlargement of the lesion, a right-sided laparoscopic adrenalectomy was performed. The cyst was lined predominantly by ciliated cuboidal-to-columnar, Müllerian-type epithelium, and focally by flat-to-cuboidal, mesothelium-like lining...
January 18, 2017: Histology and Histopathology
https://www.readbyqxmd.com/read/28090628/erk1-2-jnk-and-stat3-activation-and-correlation-with-tumor-differentiation-in-oral-scc
#15
I Gkouveris, N Nikitakis, D Avgoustidis, M Karanikou, G Rassidakis, A Sklavounou
Signal transducer and activator of transcription 3 (STAT3) and mitogen activated protein kinases (MAPKs), including ERK and JNK, have been implicated in oral squamous cell carcinoma (OSCC) development and progression. Our purpose was to evaluate the levels of activated STAT3, ERK1/2 and JNK by immunohistochemistry in OSCC and to investigate possible correlations of these molecules with each other as well as with the degree of tumor differentiation. Immunohistochemical assessment of the phosphorylated levels of STAT3(tyrosine/ serine), ERK1/2 and JNK was performed in 60 OSCC, including well, moderately and poorly differentiated tumors...
January 16, 2017: Histology and Histopathology
https://www.readbyqxmd.com/read/28083862/pathogenicity-assessment-of-wild-type-and-mouse-adapted-influenza-a-h1n1-pdm09-viruses-in-comparison-with-highly-pathogenic-influenza-a-h5n1-virus
#16
E A Prokopyeva, A A Romanovskaya, K A Sharshov, A V Zaykovskaya, A A Alekseev, A M Shestopalov
Here we compare the results of pathological and virological examinations of mice experimentally infected with either wild-type or mouse-adapted pandemic A(H1N1) pdm09 viruses and highly pathogenic avian influenza (HPAI) virus A(H5N1). Mice were sacrificed on days 1, 3, 6, and 10 post infection or whenever morbidity was severe enough to justify euthanasia. Morbidity rates were calculated on the basis of clinical signs (weight loss, poor hair coat, hunched posture and paresis); virus-induced disease was characterised by the histopathology of lung; virus dissemination was determined by virus isolation on organ samples of lung, brain, liver, kidney and spleen...
January 13, 2017: Histology and Histopathology
https://www.readbyqxmd.com/read/28078661/role-of-cytokines-in-host-defense-against-staphylococcus-aureus-skin-infection
#17
REVIEW
Guosheng Wu, Banghui Zhu, Xudong Hong, Pengfei Luo, Zhaofan Xia
Wound infection caused by Staphylococcus aureus (S. aureus) is a critical clinical problem due to long hospitalization times, significant morbidity and mortality, as well as considerable medical resource consumption. With the emergence of methicillin-resistant S. aureus (MRSA) strains, current antibiotic treatments are becoming ineffective in combatting S. aureus infection. Thus, a novel therapeutic strategy is required. Recent studies discovered that several cytokines in the infected wound area play protective roles against S...
January 12, 2017: Histology and Histopathology
https://www.readbyqxmd.com/read/28035654/seven-days-post-injury-fate-and-effects-of-genetically-labelled-adipose-derived-mesenchymal-cells-on-a-rat-traumatic-brain-injury-experimental-model
#18
Ioanna Dori, Spyros Petrakis, Aggeliki Giannakopoulou, Chryssa Bekiari, Ioannis Grivas, Evangelia K Siska, Georgios Koliakos, Georgios C Papadopoulos
Mesenchymal stromal cells (MSC) have been suggested to have beneficial effects on animal models of traumatic brain injury (TBI), owing to their neurotrophic and immunomodulatory properties. Adipose tissue-derived stromal cells (ASCs) are multipotent MSC that can be harvested with minimally invasive methods, show a high proliferative capacity, low immunogenicity if allogeneic, and can be used in autologous or heterologous settings. In the present study ASCs were genetically labelled using the Sleeping Beauty transposon to express the fluorescent protein Venus...
December 30, 2016: Histology and Histopathology
https://www.readbyqxmd.com/read/28032888/corrigendum-to-high-glucose-concentration-induced-expression-of-pentraxin-3-in-a-rat-model-of-continuous-peritoneal-dialysis
#19
Nana Ishimatsu, Tetsu Miyamoto, Hiromichi Ueno, Emi Hasegawa, Akihiro Kuma, Yoko Fujimoto, Kenichiro Bando, Junichi Nakamata, Yumi Furuno, Ryota Serino, Ryoko Baba, Hiroyuki Morimoto, Yoshiaki Doi, Masahito Tamura, Yutaka Otsuji
This correct the article DOI: 10.14670/HH-11-756.
December 29, 2016: Histology and Histopathology
https://www.readbyqxmd.com/read/28032328/targeting-exogenous-%C3%AE-defensin-to-the-endolysosomal-compartment-via-a-vehicle-guided-system
#20
Lorena Carvelli, Yuan Libin, Sherry Esfandnia, Yan Zhang, John F Presley, Carlos R Morales
A number of pathogens for which there are no effective treatments infect the cells via endocytosis. Once in the endosomes, the pathogens complete their life cycle by overriding normal lysosomal functions. Recently, our laboratory identified the lysosomal targeting signal of prosaposin, which is recognized by the sorting receptor "sortilin". Based on this evidence, we tested whether the antimicrobial peptide β-Defensin linked to the targeting sequence of prosaposin (βD-PSAP) could be redirected from its secretory pathway to the endolysosomal compartment...
December 29, 2016: Histology and Histopathology
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