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International Clinical Psychopharmacology

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https://www.readbyqxmd.com/read/29738425/a-pilot-open-label-8-week-study-evaluating-desvenlafaxine-for-treatment-of-major-depression-in-methadone-maintained-individuals-with-opioid-use-disorder
#1
Cynthia El Hage, Maykel F Ghabrash, Simon Dubreucq, Suzanne Brissette, François Lespérance, Paul Lespérance, Clairélaine Ouellet-Plamondon, Julie Bruneau, Didier Jutras-Aswad
Depression is one of the most prevalent psychiatric disorders among opioid-dependent individuals. Clinical trials testing selective serotonin reuptake inhibitors among depressed patients on methadone maintenance therapy (MMT) failed to show efficacy, whereas those on tricyclic antidepressants produced mixed results with potential for cardiotoxicity. Desvenlafaxine (DESV) is a SNRI with minimal cardiotoxicity and drug interactions. This study sought to assess feasibility and tolerability of using DESV in depressed patients on MMT...
May 7, 2018: International Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29738426/pharmacological-treatment-of-sexual-offenders-in-german-outpatient-treatment-centers
#2
Daniel Turner, Priscilla Gregório Hertz, Julia Sauter, Peer Briken, Martin Rettenberger
In Germany, depending on a sexual offender's culpability and the severity of the offence, he/she can be placed either in the forensic-psychiatric or the correctional system. Numbers related to the pharmacological treatment of sexual offenders for the correctional system are missing so far. In sexual offenders, the pharmacological treatment of paraphilic disorders is of special importance. The present study aimed at assessing the prevalence of pharmacological sexual offender treatment in German outpatient treatment centers supervising mainly clients from the correctional sector...
May 4, 2018: International Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29688914/antipsychotic-drug-exposure-and-risk-of-fracture-a-systematic-review-and-meta-analysis-of-observational-studies
#3
Davide Papola, Giovanni Ostuzzi, Lehana Thabane, Gordon Guyatt, Corrado Barbui
To investigate the extent to which exposure to first-generation and second-generation antipsychotics (APs) is associated with an increased risk of fractures, with a particular focus on hip fractures, and to ascertain the risk associated with exposure to individual drugs. We included observational studies that reported data on fractures in individuals exposed to APs compared with unexposed individuals or individuals with previous exposure. We extracted information on study design, source of data, population characteristics, outcomes of interest, matching and confounding factors, and used a modified version of the Newcastle-Ottawa Scale to judge study risk of bias...
April 23, 2018: International Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29664808/trends-in-pharmacological-emergency-treatment-of-patients-suffering-from-schizophrenia-over-a-16-year-observation-period
#4
Monika Edlinger, Anna-Sophia Welte, Nursen Yalcin-Siedentopf, Georg Kemmler, Felix Neymeyer, W Wolfgang Fleischhacker, Alex Hofer
Patients suffering from schizophrenia are often treated in locked psychiatric units because of psychomotor agitation, hostility and aggressive behavior, or suicidality. Because of legal conditions, investigations on these acutely ill patients are difficult, and many studies do not represent 'real-life psychiatry'. This retrospective survey was conducted at the Department of Psychiatry, Psychotherapy and Psychosomatics of the Medical University, Innsbruck, Austria. Data were collected from the records of all adult inpatients suffering from a schizophrenia spectrum disorder according to the International Classification of Diseases, 10th ed...
April 16, 2018: International Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29608461/vilazodone-efficacy-in-subgroups-of-patients-with-major-depressive-disorder-a-post-hoc-analysis-of-four-randomized-double-blind-placebo-controlled-trials
#5
Susan Kornstein, Cheng-Tao Chang, Carl P Gommoll, John Edwards
The efficacy of antidepressants to treat major depressive disorder (MDD) varies by patient characteristics. This post-hoc analysis evaluated the effects of vilazodone across patient subgroups in adults with MDD. Data were pooled from four trials of vilazodone (NCT00285376, NCT00683592, NCT01473394, and NCT01473381). Mean change from baseline to week 8 in Montgomery-Åsberg Depression Rating Scale (MADRS) total score, MADRS response (≥50% total score improvement), and MADRS remission (total score≤10) were analyzed in the pooled intent-to-treat population (vilazodone=1254, placebo=964) and in subgroups of patients categorized by sex, age, MDD duration, recurrent episodes, baseline MADRS total score, and current episode duration...
March 30, 2018: International Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29608460/effectiveness-of-parental-training-methylphenidate-treatment-and-their-combination-on-academic-achievements-and-behavior-at-school-of-children-with-attention-deficit-hyperactivity-disorder
#6
Pavel Golubchik, Hagar Hamerman, Iris Manor, Miriam Peskin, Abraham Weizman
This study aimed to compare the effectiveness of parental training (PT), methylphenidate treatment (MPH), and the combination of PT and MPH treatment (PT/MPH) on school achievements in children with attention-deficit hyperactivity disorder (ADHD). Twenty eight ADHD patients (age: 10.1±1.11 years) were divided into three groups: (a) PT (N=10), (b) PT/MPH (N=8), and (c) MPH alone (N=10). Their grades in academics and conduct, from their school reports before and after treatment (6 months), were coded as achievement scores...
March 30, 2018: International Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29494348/methodological-challenges-in-indirect-treatment-comparisons-spotlight-on-a-recent-comparison-of-long-acting-injectable-aripiprazole-versus-paliperidone-palmitate-in-the-treatment-of-schizophrenia
#7
Arun Singh, Srihari Gopal, Edward Kim, Maju Mathews, Jennifer Kern-Sliwa, Ibrahim Turkoz, Annette Wooller, Jesse Berlin
In a recent study, an indirect treatment comparison was performed to examine the relative efficacy and tolerability of aripiprazole once monthly and paliperidone palmitate once monthly. The authors concluded that the results may suggest relative advantages for aripiprazole once monthly over paliperidone palmitate once monthly in the short-term treatment of schizophrenia. However, the validity of the study is compromised as an indirect treatment comparison using extant data may violate important assumptions...
March 1, 2018: International Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29489495/health-service-utilization-and-medical-costs-among-patients-with-schizophrenia-receiving-long-acting-injectable-risperidone-versus-oral-risperidone-a-nationwide-retrospective-matched-cohort-study-in-taiwan
#8
Szu-Jui Fan, Ning Lu, Hui-Chih Chang, Chao-Hsiun Tang, Kuo-Cherh Huang
The aim of the nationwide retrospective matched cohort study was to evaluate health service utilization and medical costs between patients with schizophrenia who received long-acting injectable (LAI) risperidone and those who took risperidone orally. Data were sourced from the 2008 to 2013 Psychiatric Inpatient Medical Claim Dataset in Taiwan. The sample selection process was performed by propensity score matching. Finally, there were 691 patients in the exposed cohort and 1382 patients in the unexposed cohort...
February 27, 2018: International Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29489494/mineralocorticoid-receptor-related-markers-and-outcome-of-major-depression-focus-on-blood-pressure-and-electrolytes
#9
Harald Murck, Michael Ploch, Stuart Montgomery
A close association between vegetative regulation and affect is common knowledge. Recently, the role of aldosterone and the activity of its receptor [mineralocorticoid receptor (MR)] in the clinical outcome for treatment with standard antidepressants has been shown including low systolic blood pressure and a low concentration of plasma sodium (Na), both of which appear to be related to therapy resistance to standard antidepressants. We carried out a retrospective analysis of a double-blind placebo-controlled trial of St John's wort extract LI160 in 247 outpatients with major depression...
February 27, 2018: International Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29505485/off-label-antidepressant-prescription-in-pediatric-outpatients-based-on-china-food-and-drug-administration-and-food-and-drug-administration-regulations-a-chinese-retrospective-study
#10
Shuhua Deng, Xiuqing Zhu, Bin Sun, Jinqing Hu, Dewei Shang, Weijia Chen, Haoyang Lu, Xiaojia Ni, Ming Zhang, Zhanzhang Wang, Yuguan Wen, Chang Qiu
The objective of this study was to evaluate the prevalence and relative risk of off-label prescription of antidepressants in Chinese pediatric outpatients according to China Food and Drug Administration (C-FDA) and USFDA regulations. Medical records of 18 459 pediatric outpatients were identified between 2013 and 2015. Patient characteristics, prevalence of off-label antidepressant prescriptions, and relative risk factors associated with off-label prescribing were analyzed. The results indicate that patients aged from 12 to 17 years account for 88...
May 2018: International Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29489493/effects-on-the-diagnosis-change-and-on-the-disability-level-for-individuals-with-disorder-of-consciousness-which-predictors
#11
Davide Sattin, Matilde Leonardi, Davide Guido
Prediction of the functional recovery in patients with disorders of consciousness (DOC) is still complex because of the different numbers of variables that influence the possibility of observing changes in clinical outcome. The aim of the present study is to identify the best set of predictors of the change in DOC diagnosis among different pharmacotherapy and nonpharmacotherapy indicators. This study analyzed data collected in a longitudinal, two-evaluation, multicenter project conducted in 90 centers. We analyzed the predictor effects of physical and cognitive treatments, duration of disease, etiology, age, and sex (nonpharmacological treatments) as well as the use of antiparkinson, psycholeptic, psychoanaleptic, and muscle-relaxant drugs (pharmacological variables)...
May 2018: International Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29465467/outcome-and-predictors-of-remission-in-bipolar-i-patients-experiencing-manic-episode-and-treated-with-oral-antipsychotics-and-or-mood-stabilizers-a-prospective-observational-study-in-italy
#12
Giulio Perugi, Giulia Vannucchi, Margherita Barbuti, Giuseppe Maccariello, Andrea De Bartolomeis, Andrea Fagiolini, Giuseppe Maina
This observational study aimed to identify internal (clinical-demographic, temperamental characteristics) and external (childhood trauma, psychosocial characteristics) factors potentially predicting remission at 12 weeks in bipolar-I patients experiencing manic episode and requiring to start or switch treatment with oral antipsychotics and/or mood stabilizers. The following scales were administered: the Young Mania Rating Scale (YMRS), the Montgomery-Asberg Depression Rating Scale (MADRS), the Functioning Assessment Short Test (FAST), and the Clinical Global Impression for Bipolar Disorders (CGI-BP)...
May 2018: International Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29461302/does-initial-use-of-benzodiazepines-delay-an-adequate-pharmacological-treatment-a-multicentre-analysis-in-patients-with-psychotic-and-affective-disorders
#13
Benedetta Grancini, Vera De Carlo, Mariacarlotta Palazzo, Matteo Vismara, Chiara Arici, Laura Cremaschi, Beatrice Benatti, A Carlo Altamura, Bernardo Dell'Osso
It is established that delayed effective pharmacotherapy plays a significant role in the overall burden of psychiatric disorders, which are often treated with symptomatic drugs, that is benzodiazepines (BZDs), in relation to their rapid onset of action and safety, despite long-term side effects. We aimed to assess the influence of initial treatment with BZDs on the duration of untreated illness (DUI) and whether specific sociodemographic and clinical factors could influence the choice of BZDs as first treatment in 545 patients affected by schizophrenia, mood and anxiety spectrum disorders...
May 2018: International Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29406406/two-year-effectiveness-of-risperidone-and-aripiprazole-in-the-maintenance-treatment-of-patients-with-recent-onset-or-chronic-schizophrenia-and-related-psychotic-disorders-a-retrospective-multicenter-study
#14
Yusaku Yoshimura, Toshihiko Takeda, Yoshiki Kishi, Toshiki Harada, Akira Nomura, Kenji Washida, Bunta Yoshimura, Kojiro Sato, Yuji Yada, Shozo Aoki
This study aimed to assess the comparative effectiveness of risperidone (RIS) versus aripiprazole (ARP) in patients with recent-onset or chronic schizophrenia during maintenance treatment and to examine the interaction between illness duration and the effectiveness of the treatment. All adult patients with schizophrenia and related disorders discharged from four psychiatric hospitals between 2006 and 2012 were screened and the 2-year continuation rates of monotherapy using RIS or ARP after discharge were examined retrospectively...
May 2018: International Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29324468/switching-antipsychotic-treatment-to-aripiprazole-in-psychotic-patients-with-neuroleptic-induced-tardive-dyskinesia-a-24-week-follow-up-study
#15
Chia-Hsiang Chan, Hung-Yu Chan, Yen-Ching Chen
Aripiprazole is a second-generation antipsychotics, acting as a partial dopamine D2 receptor agonist. Previous studies on aripiprazole for tardive dyskinesia (TD) treatment were limited and inconclusive. This study was aimed to examine the effectiveness of aripiprazole in psychotic patients with a pre-existing TD. This was an open-label 24-week prospective cohort study conducted in a public mental hospital in Northern Taiwan from January 2009 to February 2010. Psychotic patients were cross-titrated of prior antipsychotics with aripiprazole, and the severity of TD was assessed at baseline and at weeks 2, 4, 8, 12, 16, 20, and 24...
May 2018: International Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29389697/pharmacotherapy-for-primary-delusional-jealousy-a-retrospective-observational-study-of-32-cases-with-othello-syndrome
#16
Chen-Chung Liu, Yen-Chin Wang, Tzung-Jeng Hwang
To determine whether primary delusional jealousy can be treated effectively with antipsychotics or antidepressants, and whether any clinical variables are associated with response to pharmacotherapy, we carried out a retrospective case series observational study by reviewing clinical records of patients with an International Classification of Disease, 9th ed., diagnostic code of 297 (delusional disorders) who were treated at the Department of Psychiatry of a university affiliated hospital from January 2010 to December 2015...
March 2018: International Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29112517/use-of-antidementia-drugs-in-german-patients-with-alzheimer-s-disease
#17
Philipp Hessmann, Richard Dodel, Erika Baum, Matthias J Müller, Greta Paschke, Bernhard Kis, Jan Zeidler, Mike Klora, Jens-Peter Reese, Monika Balzer-Geldsetzer
The objective of this study was to evaluate the use of antidementia drugs (ADDs) in patients with Alzheimer's disease (AD) regarding German guideline recommendations and to assess correlations between the use of ADDs and the patients' characteristics. A total of 395 community-dwelling and institutionalized patients with AD across all severity stages of dementia were recruited in this cross-sectional study. Associations between the prescription of ADDs and patients' sociodemographic and clinical parameters (neuropsychiatric symptoms, cognitive capacity, daily activities, and health-related quality of life) were analyzed in multiple logistic regression analyses...
March 2018: International Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29112001/a-phase-ii-study-to-evaluate-the-pharmacokinetics-safety-and-tolerability-of-risperidone-ism-multiple-intramuscular-injections-once-every-4-weeks-in-patients-with-schizophrenia
#18
Lourdes Anta, Jordi Llaudó, Ignacio Ayani, Javier Martínez, Robert E Litman, Ibón Gutierro
This study characterized the pharmacokinetics, safety, and tolerability of Risperidone ISM, a new long-acting intramuscular formulation, for monthly administration without oral supplementation. Patients with schizophrenia received multiple intramuscular injections of 75 mg in the gluteal or deltoid muscle at 28-day intervals. Of the 70 randomized patients, 67 received at least one dose of study medication. The mean Cmax of the active moiety was achieved 24-48 h (tmax) after each administration, regardless of injection site...
March 2018: International Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29084087/salsalate-as-an-adjunctive-treatment-for-psychopathology-and-cognition-in-patients-with-schizophrenia-a-pilot-study
#19
Yanli Luo, Fang Liu, Radhika Natarajan, Nawras Shukair, Paul Copeland, Xiaoduo Fan
This pilot study examined the effect of adjunctive salsalate on psychopathology and cognition in patients with schizophrenia. This was a 12-week, open-label trial of salsalate (1.5 g, twice per day) in patients with schizophrenia. Psychopathology, cognition, and daily function were assessed at baseline and week 12 using various rating scales. Blood levels of inflammatory markers including white blood cell count, high-sensitivity C-reactive protein, and interleukin-6 levels were also measured. Eight patients completed the study...
March 2018: International Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29068794/results-from-a-drug-utilization-study-of-extended-release-quetiapine-fumarate-prescribed-by-psychiatrists-as-treatment-for-major-depressive-disorder-in-selected-countries-in-the-european-union
#20
Robert S Brody, Charles L Liss, Heather Wray, Kari Kastango, Allison Bryant, Alban Fabre, Anneli Thuresson
This multicenter, observational drug utilization (DU) study (NCT01594996) investigated the profile of patients and specialist providers who prescribed extended release quetiapine fumarate (quetiapine XR) for treatment of major depressive disorder (MDD) across five European countries (Germany, Italy, Romania, Spain, and Sweden). A DU data abstraction form captured information on the characteristics of physicians, patients, and drugs utilized in the medical management of depressive episodes in MDD, where the therapeutic regimen included quetiapine XR...
March 2018: International Clinical Psychopharmacology
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