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Pancreas

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https://www.readbyqxmd.com/read/30211807/analysis-of-a-step-up-approach-versus-primary-open-surgical-necrosectomy-in-the-management-of-necrotizing-pancreatitis-experience-in-a-cohort-of-patients-at-a-us-academic-medical-center
#1
Jason D Jones, Clancy J Clark, Raymond Dyer, Doug Case, Girish Mishra, Rishi Pawa
OBJECTIVES: An increasing number of providers have begun to use a minimally invasive step-up approach as opposed to traditional surgical necrosectomy in the management of acute necrotizing pancreatitis. Studies have shown mixed results, thus we hypothesized that the step-up approach is safer and associated with decreased mortality and length of stay (LOS). METHODS: This is a retrospective cohort study of patients admitted from January 2010 to March 2015 who underwent interventions for walled-off pancreatic necrosis (WOPN)...
September 11, 2018: Pancreas
https://www.readbyqxmd.com/read/30211806/free-thyroxine-determination-in-the-emergency-department-is-a-predictor-of-acute-pancreatitis-evolution
#2
Gonzalo Callejón, Emilia Redondo, Marilina Garcia-Aranda, José Antonio Castilla-Alcalá, Alexandra Prados-Torres, Maximino Redondo
OBJECTIVE: The aim of this study was to determine the prevalence and type of thyroid hormone levels alterations in patients with acute pancreatitis (AP) and analyze if variations are useful AP progression predictors. METHODS: Three groups of patients were analyzed: AP patients (n = 90), abdominal pain patients (n = 30), and healthy control subjects (n = 40). Usual blood parameters for AP diagnosis and prognosis, thyroid-stimulating hormone (or thyrotropin), FT4 (free thyroxine), FT3 (free triiodothyronine), and TT3 (total triiodothyronine) levels were analyzed...
September 11, 2018: Pancreas
https://www.readbyqxmd.com/read/30211805/grading-by-the-ki-67-labeling-index-of-endoscopic-ultrasound-guided-fine-needle-aspiration-biopsy-specimens-of-pancreatic-neuroendocrine-tumors-can-be-underestimated
#3
Hee Sang Hwang, YunJae Kim, Soyeon An, Sung Joo Kim, Joo Young Kim, Sang-Yeob Kim, Dae Wook Hwang, Do Hyun Park, Sang Soo Lee, Song Cheol Kim, Dong-Wan Seo, Seung-Mo Hong
OBJECTIVES: There is an increasing need for grading with small endoscopic ultrasound-guided fine needle aspiration biopsy (EUS-FNAB) specimens for the proper diagnosis and therapy selection of patients with unresectable pancreatic neuroendocrine tumors (PanNET). However, our understanding of EUS-FNAB specimen grading is limited compared with surgically resected specimens. METHODS: We retrospectively determined Ki-67 labeling index (LI) of 33 matched EUS-FNAB and surgically resected PanNETs with digital image analyzer...
September 11, 2018: Pancreas
https://www.readbyqxmd.com/read/30211804/progression-of-structural-brain-changes-in-patients-with-chronic-pancreatitis-and-its-association-to-chronic-pain-a-7-year-longitudinal-follow-up-study
#4
Janusiya Muthulingam, Søren Schou Olesen, Tine Maria Hansen, David A Seminowicz, Shana Burrowes, Asbjørn Mohr Drewes, Jens Brøndum Frøkjær
OBJECTIVES: Temporal information about the structural brain changes in chronic pancreatitis (CP) and its relation to the clinical manifestations is lacking. This study investigated changes in morphological brain parameters over 7 years in painful CP patients, compared with controls. METHODS: In this 7-year longitudinal magnetic resonance imaging study, we included 23 CP patients and 14 controls. Gray matter volume (GMV) and cortical thickness were examined using voxel-based and surface-based morphometry...
September 11, 2018: Pancreas
https://www.readbyqxmd.com/read/30199493/cohort-study-of-overutilization-of-preventive-screening-for-patients-with-pancreatic-cancer
#5
Alexander V Fisher, Daniel E Abbott, Sara Fernandes-Taylor, Jeffrey A Havlena, Xing Wang, Ying Shan, Elise H Lawson, Emily R Winslow, Sharon M Weber, Jessica R Schumacher
No abstract text is available yet for this article.
October 2018: Pancreas
https://www.readbyqxmd.com/read/30199492/islet-graft-function-is-preserved-after-pregnancy-in-patients-with-previous-total-pancreatectomy-with-islet-autotransplant
#6
Mariya E Skube, Pamela D Mills, James S Hodges, Greg J Beilman, Melena D Bellin
No abstract text is available yet for this article.
October 2018: Pancreas
https://www.readbyqxmd.com/read/30199491/pancreatic-panniculitis-a-series-of-4-cases-associated-with-pancreatic-and-ampullary-disease
#7
Paul Heitmann, Corinne Maiolo, Jan Ibbetson, Shireen Sidhu, Paul Dolan
No abstract text is available yet for this article.
October 2018: Pancreas
https://www.readbyqxmd.com/read/30199490/stabilized-incidence-of-pediatric-acute-pancreatitis
#8
Lindsey N Hornung, Flora K Szabo, Heidi J Kalkwarf, Maisam Abu-El-Haija
No abstract text is available yet for this article.
October 2018: Pancreas
https://www.readbyqxmd.com/read/30199489/patients-with-pancreatic-ductal-adenocarcinoma-have-high-serum-galectin-9-levels-a-sweet-molecule-to-keep-an-eye-on
#9
Lucas B Tavares, Antônio F Silva-Filho, Mario R Martins, Kamila M Vilar, Maira G R Pitta, Moacyr J B M Rêgo
No abstract text is available yet for this article.
October 2018: Pancreas
https://www.readbyqxmd.com/read/30199488/metformin-and-pancreatic-cancer-risk-in-patients-with-type-2-diabetes
#10
Chin-Hsiao Tseng
No abstract text is available yet for this article.
October 2018: Pancreas
https://www.readbyqxmd.com/read/30199487/pancreatic-cancer-associated-depression-a-case-report-and-review-of-the-literature
#11
Adam F Barnes, Theresa P Yeo, Benjamin Leiby, Abigail Kay, Jordan M Winter
The prevalence of major depressive disorder (MDD) in pancreatic cancer (PC) has been reported up to 7 times higher than the general population. Despite repeated studies that show worse quality of life, survival outcomes, and treatment compliance in cancer patients with depression, baseline antidepressant use ranges from 15% to 27%. A meta-analysis of 6 prospective trials specific to PC estimates that 43% of patients with PC experience depression after diagnosis. This is especially alarming in patients with PC, who may experience a prodrome of symptoms including depression and loss of drive...
October 2018: Pancreas
https://www.readbyqxmd.com/read/30199486/role-of-radiological-imaging-in-the-diagnosis-and-characterization-of-pancreatic-cystic-lesions-a-systematic-review
#12
Eyas Mohamed, Richard Jackson, Christopher M Halloran, Paula Ghaneh
The evidence on the ability of radiological tests to predict a specific diagnosis and also their aptitude in identifying pathological markers indicative of malignancy in cystic lesions of the pancreas remains inconclusive. We conducted a systematic review on MEDLINE for the use of computed tomography (CT), magnetic resonance imaging, and positron emission tomography/CT (PET/CT) in the diagnosis and characterization of these cysts. The accuracy of CT scan for reaching a specific diagnosis was 39% to 61.4%, whereas its accuracy for differentiating benign from malignant lesions was 61...
October 2018: Pancreas
https://www.readbyqxmd.com/read/30199485/harnessing-analytic-morphomics-for-early-detection-of-pancreatic-cancer
#13
Maxim S Petrov
No abstract text is available yet for this article.
October 2018: Pancreas
https://www.readbyqxmd.com/read/30192316/histidine-rich-glycoprotein-suppresses-hyperinflammatory-responses-of-lung-in-a-severe-acute-pancreatitis-mouse-model
#14
Kinya Terao, Hidenori Wake, Naoto Adachi, Keyue Liu, Kiyoshi Teshigawara, Hideo Takahashi, Shuji Mori, Masahiro Nishibori
OBJECTIVES: Severe acute pancreatitis is a highly lethal disease caused by systemic inflammatory response syndrome, leading to multiple organ failure. We recently showed that histidine-rich glycoprotein (HRG) supplemental therapy ameliorated septic acute respiratory distress syndrome due to unnecessary neutrophil activation and immunothrombosis formation. Here, we evaluated the effect of HRG on lung inflammation followed by pancreatitis in a severe acute pancreatitis mouse model. METHODS: Mice received intraperitoneal injections of cerulein 7 times (100 μg/kg each) at 1-hour intervals to induce acute pancreatitis...
October 2018: Pancreas
https://www.readbyqxmd.com/read/30192315/distinct-inflammatory-changes-of-the-pancreas-of-slowly-progressive-insulin-dependent-type-1-diabetes
#15
Kaoru Aida, Tomoyasu Fukui, Erika Jimbo, Soroku Yagihashi, Akira Shimada, Yoichi Oikawa, Yasumichi Mori, Takeshi Fujii, Yoriko Nishida, Rikako Koyama, Tetsuro Kobayashi
OBJECTIVE: The aim of this study was to identify the distinct pathological changes on the endocrine and exocrine pancreas of slowly progressive insulin-dependent diabetes mellitus (SPIDDM) or latent autoimmune diabetes in adults. METHODS: The pancreases from 12 islet autoantibody-positive SPIDDM patients and 19 age-matched subjects with no diabetes were examined histologically for islet inflammation/insulitis, expressions of cytokines, and enterovirus VP1 protein, exocrine pancreatic inflammation, pancreatic ductal changes, major histocompatibility complex class I hyperexpression, and amylin-positive amyloid in the islets...
October 2018: Pancreas
https://www.readbyqxmd.com/read/30161074/serum-marker-score-based-on-prognostic-nutrition-index-carcinoembryonic-antigen-and-carbohydrate-antigen-19-9-is-associated-with-recurrence-for-patients-undergoing-surgery-for-pancreatic-ductal-adenocarcinoma
#16
Shigeki Nakagawa, Yo-Ichi Yamashita, Naoki Umezaki, Takanobu Yamao, Hirohisa Okabe, Katsunori Imai, Hidetoshi Nitta, Daisuke Hashimoto, Akira Chikamoto, Hideo Baba
OBJECTIVES: The prognostic value of the prognostic nutrition index (PNI) in pancreatic ductal adenocarcinoma (PDAC) is still controversial. This study aimed to assess the correlation between PNI and the outcome for PDAC patients and to generate a new score from PNI and serum markers. METHODS: This study investigated 151 patients who underwent pancreatic resection for PDAC between April 2002 and June 2012. Disease-free survival (DFS), overall survival, and clinicopathological parameters were analyzed according to the PNI value...
October 2018: Pancreas
https://www.readbyqxmd.com/read/30153220/characterization-of-the-neuroendocrine-tumor-immune-microenvironment
#17
Annacarolina da Silva, Michaela Bowden, Sui Zhang, Yohei Masugi, Aaron R Thorner, Zachary T Herbert, Chensheng Willa Zhou, Lauren Brais, Jennifer A Chan, F Stephen Hodi, Scott Rodig, Shuji Ogino, Matthew H Kulke
OBJECTIVES: The immune environment and the potential for neuroendocrine tumors (NETs) to respond to immune checkpoint inhibitors remain largely unexplored. We assessed immune checkpoint marker expression, lymphocytic infiltrate, and associated mutational profiles in a cohort of small intestine and pancreatic NETs. METHODS: We assessed expression of PDCD1 (PD-1), CD274 (PD-L1), and PDCD1LG2 (PD-L2) in archival tissue from 64 small intestine (SINETs) and 31 pancreatic NETs (pNET)...
October 2018: Pancreas
https://www.readbyqxmd.com/read/30153219/in-reply-telotristat-ethyl-for-patients-with-carcinoid-syndrome-associated-with-chest-pain-and-hypertension
#18
Wenjun Jiang, Raul Perez-Olle, Pablo Lapuerta
No abstract text is available yet for this article.
October 2018: Pancreas
https://www.readbyqxmd.com/read/30142120/prediction-and-management-for-relapse-of-type-1-autoimmune-pancreatitis-after-initial-steroid-treatment-a-long-term-follow-up-from-china
#19
Lei Xin, Qian-Qian Meng, Liang-Hao Hu, Han Lin, Jun Pan, Lu Hao, Pei-Pei Liu, Wei Qian, Luo-Wei Wang, Zhao-Shen Li
OBJECTIVES: This study aimed to investigate the frequency, predictors, and management of relapse of type 1 autoimmune pancreatitis (AIP) after steroid treatment. METHODS: One hundred one patients with type 1 AIP receiving steroid as initial treatment were enrolled. Predictors were identified by multivariate analysis using Cox proportional hazards model. Hazard ratios (HRs) and 95% confidence intervals (95% CIs) were calculated. RESULTS: Thirty-nine (41...
October 2018: Pancreas
https://www.readbyqxmd.com/read/30142119/the-role-of-endoscopic-ultrasonography-and-magnetic-resonance-cholangiopancreatography-in-patients-with-acute-pancreatitis-after-negative-computed-tomography-findings-of-the-etiology
#20
Dae Bum Kim, Chang-Nyol Paik, Do Seon Song, Hyun A Kim, Yeon-Ji Kim, Ji Min Lee, Seong Su Hwang
OBJECTIVES: We aimed to investigate the roles of endoscopic ultrasonography (EUS) and magnetic resonance cholangiopancreatography (MRCP) in detecting the causes of acute pancreatitis after negative computed tomography (CT) findings. METHODS: Demographic characteristics, blood test results, the severity of pancreatitis, and definite or possible etiology of pancreatitis by EUS and MRCP were evaluated prospectively in 65 consecutively admitted patients after negative CT findings...
October 2018: Pancreas
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