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Pancreas

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https://www.readbyqxmd.com/read/29351122/how-to-reliably-assess-nodal-status-in-distal-pancreatectomy-for-adenocarcinoma
#1
Matthieu Faron, Hélène Vuarnesson, Jean-Marie Boher, Philippe Bachellier, Alain Sauvanet, Antonio Sa Cunha, Yves-Patrice Le Treut, Jean-Yves Mabrut, Jean-Robert Delpero, François Paye
OBJECTIVES: The optimal number of lymph nodes that need to be analyzed to reliably assess nodal status in distal pancreatectomy for adenocarcinoma is still unknown. METHODS: Two hundred seventy-eight patients who underwent distal pancreatectomy for adenocarcinoma were retrieved from a retrospective French nationwide database. The relations between the number of analyzed lymph nodes and the nodal status of the tumor were studied. The beta-binomial law was used to estimate the probability of being truly node negative depending on the number of analyzed lymph nodes...
January 18, 2018: Pancreas
https://www.readbyqxmd.com/read/29351121/serum-immunoglobulin-g4-in-discriminating-autoimmune-pancreatitis-from-pancreatic-cancer-a-diagnostic-meta-analysis
#2
Cong Dai, Qin Cao, Min Jiang, Ming-Jun Sun
OBJECTIVE: Differentiation between autoimmune pancreatitis (AIP) and pancreatic cancer (PC) is a clinical challenge. Emerging published data on the accuracy of serum immunoglobulin G4 (IgG4) for the differential diagnosis between AIP and PC are inconsistent. The objective of our study was to perform a meta-analysis evaluating the clinical utility of serum IgG4 in the differential diagnosis between AIP and PC. METHODS: We performed a systematic literature search of multiple electronic databases...
January 18, 2018: Pancreas
https://www.readbyqxmd.com/read/29351120/grading-using-ki-67-index-and-mitotic-rate-increases-the-prognostic-accuracy-of-pancreatic-neuroendocrine-tumors
#3
Prejesh Philips, David A Kooby, Shishir Maithel, Nipun B Merchant, Sharon M Weber, Emily R Winslow, Syed Ahmad, Hong J Kim, Charles R Scoggins, Kelly M McMasters, Robert C G Martin
OBJECTIVES: To measure the usefulness of Ki-67 proliferative index (Ki-67 index) as a prognostic variable for grading pancreatic neuroendocrine tumors. METHODS: A multi-institutional prospective database comprising 350 patients. Grading based on mitotic activity (<2 mitoses/10 high-power fields, 2-20 and >20) and Ki-67 index (<3% per 10 high-power fields, 3%-20% and >20%). Final grade selected based on higher grade of either variable. RESULTS: Most patients were in the less than 3% (n = 158) and 3% to 20% Ki-67 category (n = 107), with a minority being high-grade (Ki-67 > 20%, n = 27)...
January 18, 2018: Pancreas
https://www.readbyqxmd.com/read/29329161/utility-of-endoscopic-ultrasonography-screening-for-small-pancreatic-cancer-and-proposal-for-a-new-scoring-system-for-screening
#4
Ryota Sagami, Hidefumi Nishikiori, Katsuhiro Anami, Shozo Fujiwara, Koichi Honda, Shoichiro Ikuyama, Masayuki Kitano, Kazunari Murakami
OBJECTIVES: This study aimed to evaluate the utility of endoscopic ultrasonography screening for small pancreatic cancer (PC) and propose a new simple scoring system for selecting individuals who should be screened. METHODS: Risk factors or symptoms related to PC were tentatively divided into high- and low-grade risk groups based mainly on reported relative risk values. Numbers of risk factors were designated as risk scores. Endoscopic ultrasonography screening was performed for 632 individuals...
January 12, 2018: Pancreas
https://www.readbyqxmd.com/read/29329160/predictive-effect-of-the-total-number-of-examined-lymph-nodes-on-n-staging-and-survival-in-pancreatic-neuroendocrine-neoplasms
#5
Xianbin Zhang, Lili Lu, Peng Liu, Fei Cao, Yushan Wei, Li Ma, Peng Gong
OBJECTIVES: We aim to examine the predictive effect of the total number of examined lymph nodes on N stage and survival in pancreatic neuroendocrine neoplasms (pNENs) and to determine the optimal threshold. METHODS: A pNENs data set from 2004 to 2013 was extracted from the Surveillance, Epidemiology, and End Result database. Multivariate logistic regression and Cox proportional hazards model were used to identify predictive factors associated with N stage and survival, respectively...
January 12, 2018: Pancreas
https://www.readbyqxmd.com/read/29329159/overexpression-of-the-long-noncoding-rna-homeboxa-transcript-at-the-distal-tip-predicts-poor-prognosis-in-a-kras-independent-manner-in-periampullary-region-tumors
#6
Ozkan Balcin, Secil Ak Aksoy, Berrin Tunca, Ekrem Kaya, Unal Egeli, Gulcin Tezcan, Nesrin Ugras, Gulsah Cecener, Ozgen Isik, Halit Ziya Dundar, Omer Yerci
OBJECTIVES: Periampullary region tumors (PRTs) are the fifth highest cause of cancer-related deaths worldwide. Although recent studies have highlighted the prognostic value of the long noncoding RNA HomeboxA transcript at the distal tip (HOTTIP) in patients with pancreatic ductal adenocarcinoma, the relationship between HOTTIP and clinical outcome of all PRTs remains obscure. The aim of this study was to clarify the prognostic significance of HOTTIP in patients with all PRTs related to KRAS mutational status...
January 12, 2018: Pancreas
https://www.readbyqxmd.com/read/29329158/expression-of-gastrin-family-peptides-in-pancreatic-islets-and-their-role-in-%C3%AE-cell-function-and-survival
#7
Dawood Khan, Srividya Vasu, R Charlotte Moffett, Nigel Irwin, Peter R Flatt
OBJECTIVES: Modulation of cholecystokinin (CCK) receptors has been shown to influence pancreatic endocrine function. METHODS: We assessed the impact of the CCKA and CCKB receptor modulators, (pGlu-Gln)-CCK-8 and gastrin-17, respectively, on β-cell secretory function, proliferation and apoptosis and glucose tolerance, and investigating alterations of CCK and gastrin islet expression in diabetes. RESULTS: Initially, the presence of CCK and gastrin, and expression of their receptors were evidenced in β-cell lines and mouse islets...
January 12, 2018: Pancreas
https://www.readbyqxmd.com/read/29329157/smad4-loss-correlates-with-higher-rates-of-local-and-distant-failure-in-pancreatic-adenocarcinoma-patients-receiving-adjuvant-chemoradiation
#8
Joseph M Herman, Salma K Jabbour, Steven H Lin, Matthew P Deek, Charles C Hsu, Elliot K Fishman, Sinae Kim, John L Cameron, Marina Chekmareva, Daniel A Laheru, Amol K Narang, Timothy M Pawlik, Ralph H Hruban, Christopher L Wolfgang, Christine A Iacobuzio-Donahue
OBJECTIVES: The tumor suppressor gene SMAD4 (DPC4) is genetically inactivated in approximately half of pancreatic ductal adenocarcinomas (PDAs). We examined whether Smad4 tumor status was associated with outcomes after adjuvant chemoradiation (CRT) for resected PDAs. METHODS: Patients treated with adjuvant CRT were identified (N = 145). Smad4 status was determined by immunolabeling and graded as intact or lost. Kaplan-Meier method and multivariable competing risk analyses were performed...
January 12, 2018: Pancreas
https://www.readbyqxmd.com/read/29329156/impact-of-integrated-health-care-delivery-on-racial-and-ethnic-disparities-in-pancreatic-cancer
#9
Jonathan I Chang, Brian Z Huang, Bechien U Wu
OBJECTIVES: The objective of this study was to evaluate whether disparities in pancreatic cancer diagnosis, treatment, and survival are reduced in an integrated health system. METHODS: We conducted a retrospective study (2006-2014) among patients with pancreatic cancer from Kaiser Permanente Southern California. Racial ethnic groups included non-Hispanic whites (NHW), non-Hispanic blacks (NHB), Hispanics, and Asians. We used multivariable and Cox regression analyses to evaluate disparities in diagnosis and treatment utilization (oncology care, surgery, time to surgery, chemotherapy) and overall survival, respectively...
January 12, 2018: Pancreas
https://www.readbyqxmd.com/read/29303912/transforming-growth-factor-%C3%AE-and-bone-morphogenetic-protein-2-regulation-of-microrna-200-family-in-chronic-pancreatitis
#10
Peter Yu, Ka Liu, Xuxia Gao, Harry Karmouty-Quintana, Jennifer M Bailey, Yanna Cao, Tien C Ko
OBJECTIVES: To investigate regulation of microRNA (miR)-200 family (a, b, c, 141, and 429) in chronic pancreatitis (CP). This was accomplished by examining miR-200 family levels in a mouse model in vivo and their regulation in pancreatic cells in vitro. METHODS: Chronic pancreatitis was induced by cerulein for 4 weeks (50 μg/kg, 5 hourly intraperitoneal injections/day, and 3 days/week). Control mice received normal saline. The pancreata were harvested for fibrosis assessment by Sirius red staining and for miRNA, collagen, and fibronectin levels by quantitative PCR...
January 5, 2018: Pancreas
https://www.readbyqxmd.com/read/29303911/histone-deacetylase-inhibition-restores-expression-of-hypoxia-inducible-protein-ndrg1-in-pancreatic-cancer
#11
Céline Tiffon
OBJECTIVES: N-myc downstream-regulated gene-1 (NDRG1) is a hypoxia-inducible and differentiation-related protein and candidate biomarker in pancreatic cancer. As NDRG1 expression is lost in high-grade tumors, the effects of the differentiating histone deacetylase inhibitor trichostatin A (TSA) were examined in human pancreatic cancer cell lines representing different tumor grades. METHODS: PANC-1 (poorly differentiated) and Capan-1 (moderately to well differentiated) cells were treated with TSA...
January 5, 2018: Pancreas
https://www.readbyqxmd.com/read/29303910/involvement-of-nucleotide-binding-and-oligomerization-domain-like-receptors-in-the-intestinal-injury-of-severe-acute-pancreatitis-in-rats
#12
Shan Xu, Shuqing Wei, Yu Guo, Donglai Cui, Jinfeng Yao
OBJECTIVES: The aim of the study was to observe the role of nucleotide-binding and oligomerization domain (NOD)-like receptors (NLR) in intestine injury of severe acute pancreatitis (SAP) in rats. METHODS: Severe acute pancreatitis was induced by retrograde infusion of sodium taurocholate into the biliopancreatic duct. Rats were divided into the following 6 groups: sham operation, SAP treated with saline, and SAP treated with interleukin 1β (IL-1β)-converting enzyme inhibitor, killed at 6 or 12 hours after operation...
January 5, 2018: Pancreas
https://www.readbyqxmd.com/read/29303909/pancreatic-cancer-mortality-in-china-characteristics-and-prediction
#13
Xiaoyue Jia, Peiling Du, Kusheng Wu, Zhenxi Xu, Jiaying Fang, Xiaoling Xu, Kun Lin
OBJECTIVES: During the last decade, the mortality rate of pancreatic cancer in China has significantly increased. We analyzed data for the period 1991-2014 to investigate the distribution of mortality rates and predict trends for the next 5 years. METHODS: We obtained the pancreatic mortality data from the Chinese cancer annual report. Trend surface analysis was applied to study the geographical distribution. We used curve estimation, time series, gray modeling, and joinpoint regression to predict the mortality rate...
January 5, 2018: Pancreas
https://www.readbyqxmd.com/read/29303908/progression-of-chronic-pancreatitis-to-pancreatic-cancer-is-there-a-role-of-gene-mutations-as-a-screening-tool
#14
Sumaira Rashid, Nidhi Singh, Surabhi Gupta, Safoora Rashid, Nandini Nalika, Vikas Sachdev, Chandra Sekhar Bal, Siddhartha Datta Gupta, Shyam S Chauhan, Anoop Saraya
OBJECTIVES: Early detection of pancreatic ductal adenocarcinoma still remains a challenge. Patients with chronic pancreatitis (CP) have a markedly increased risk of pancreatic cancer. Mutations in oncogenes and/or tumor suppressor genes play a role in development of pancreatic ductal adenocarcinoma. This study assessed mutations in KRAS and p53 gene in blood as a screening tool for malignant transformation in CP patients. METHODS: This was a cohort, single-center study including 294 CP patients...
January 5, 2018: Pancreas
https://www.readbyqxmd.com/read/29215541/pancreatic-insufficiency-in-cystic-fibrosis-influence-of-inflammatory-response-genes
#15
Fernando Augusto Lima Marson, Carmen Sílvia Bertuzzo, Tânia Kawasaki de Araujo, Taís Daiene Russo Hortencio, Antônio Fernando Ribeiro, José Dirceu Ribeiro
OBJECTIVE: Pancreatic insufficiency (PI) in cystic fibrosis (CF) patients is a crucial clinical marker for severity and disease progression. In our study, 125 modifier genes and their SNPs were associated between CF patients with PI or pancreatic sufficiency. METHODS: We prospectively evaluated 214 CF patients admitted at 1 hospital for a 2-year period. The PI status was associated with clinical variables and SNPs related with inflammatory response considering CFTR mutations...
December 5, 2017: Pancreas
https://www.readbyqxmd.com/read/29215536/comparison-of-various-scoring-systems-and-biochemical-markers-in-predicting-the-outcome-in-acute-pancreatitis
#16
Sreejith Vasudevan, Pooja Goswami, Ujjwal Sonika, Bhaskar Thakur, Vishnubhatla Sreenivas, Anoop Saraya
OBJECTIVE: Early risk assessment is important in acute pancreatitis (AP). The primary objective of this study was to compare various scores and biochemical markers done on the day of admission in predicting the outcome. METHODS: Demographic, clinical, and laboratory data of patients presenting within 2 weeks of onset were collected. Various scores were calculated and biochemical markers were measured on the day of admission. Optimum cutoffs were identified through receiver operating curve analysis...
December 5, 2017: Pancreas
https://www.readbyqxmd.com/read/29215535/the-clinicopathological-aspects-of-primary-presacral-neuroendocrine-neoplasms-one-center-experience
#17
Guoqing Yang, Deepti Dhall, Run Yu, Richard Tuli, Farin F Amersi, Marc L Friedman, Nicholas N Nissen, Andrew E Hendifar
OBJECTIVES: Presacral neuroendocrine neoplasms (NENs) are rare entities that are found at the presacral space. We report our experience in the diagnosis, management, and outcomes of primary presacral NENs. METHODS: This was an institutional review board-approved retrospective review of medical records and surgical pathology specimens of patients with a diagnosis of NENs at Cedars-Sinai Medical Center between January 2000 and April 2016. RESULTS: Ten patients were identified...
December 5, 2017: Pancreas
https://www.readbyqxmd.com/read/29206668/treatment-patterns-and-clinical-outcomes-in-patients-with-metastatic-gastroenteropancreatic-neuroendocrine-tumors-treated-in-the-community-practice-setting-in-the-united-states
#18
Xiaolong Jiao, Sonia Pulgar, Marley Boyd, Fadi Braiteh, Beloo Mirakhur, Susan Pitman Lowenthal, Patricia Fox, Jennifer Frytak, David Cox, Andrew Scott Paulson
OBJECTIVE: This study was conducted to understand treatment patterns and clinical outcomes in metastatic gastroenteropancreatic neuroendocrine tumor patients treated in a large community oncology network. METHODS: This retrospective study used the McKesson Specialty Health/US Oncology Network iKnowMed electronic health record database with supplemental chart review. Eligibility criteria included a metastatic neuroendocrine tumor diagnosis between January 1, 2008, and to December 31, 2012; at least 2 US Oncology Network visits; and age at least 18 years...
December 5, 2017: Pancreas
https://www.readbyqxmd.com/read/29206667/total-pancreatectomy-with-intraportal-islet-autotransplantation-as-a-treatment-of-chronic-pancreatitis-in-patients-with-cftr-mutations
#19
Kristin P Colling, Melena D Bellin, Sarah J Schwarzenberg, Louise Berry, Joshua J Wilhelm, Ty Dunn, Timothy L Pruett, David E R Sutherland, Srinath Chinnakotla, Jordan M Dunitz, Greg J Beilman
OBJECTIVES: Chronic pancreatitis (CP) is an infrequent but debilitating complication associated with CFTR mutations. Total pancreatectomy with islet autotransplantation (TPIAT) is a treatment option for CP that provides pain relief and preserves β-cell mass, thereby minimizing the complication of diabetes mellitus. We compared outcomes after TPIAT for CP associated with CFTR mutations to CP without CTFR mutations. METHODS: All TPIATs performed between 2002 and 2014 were retrospectively reviewed: identifying 20 CFTR homozygotes (cystic fibrosis [CF] patients), 19 CFTR heterozygotes, and 20 age-/sex-matched controls without CFTR mutations...
December 5, 2017: Pancreas
https://www.readbyqxmd.com/read/29200129/the-effect-of-pancreatic-juice-collection-time-on-the-detection-of-kras-mutations
#20
Masaya Suenaga, Beth Dudley, Eve Karloski, Michael Borges, Marcia Irene Canto, Randall E Brand, Michael Goggins
OBJECTIVE: Secretin-stimulated pancreatic juice is collected from the duodenum and analyzed to identify biomarkers of pancreatic neoplasia, but the optimal duration of pancreatic juice collection is not known. METHODS: We compared the yield of KRAS mutations detected in pancreatic juice samples aspirated from near the duodenal papilla at 1 to 5, 6 to 10, and 11 to 15 minutes after secretin infusion, and from the third part of the duodenum (at 15 minutes) from 45 patients undergoing endoscopic ultrasound pancreatic surveillance...
December 2, 2017: Pancreas
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