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Pancreas

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https://www.readbyqxmd.com/read/30383711/abstracts-of-papers-submitted-to-the-49th-annual-meeting-of-the-american-pancreatic-association-october-31-november-3-2018-miami-beach-florida
#1
(no author information available yet)
No abstract text is available yet for this article.
November 2018: Pancreas
https://www.readbyqxmd.com/read/30325868/author-index-for-american-pancreatic-association-abstracts
#2
(no author information available yet)
No abstract text is available yet for this article.
November 2018: Pancreas
https://www.readbyqxmd.com/read/30325867/minutes-of-the-business-meeting-of-the-american-pancreatic-association-friday-november-10-2017-san-diego-california
#3
(no author information available yet)
No abstract text is available yet for this article.
November 2018: Pancreas
https://www.readbyqxmd.com/read/30325866/solid-pseudopapillary-neoplasm-of-the-pancreas-in-a-young-pediatric-patient-a-case-report-and-systematic-review-of-the-literature
#4
Alexandra M Bender, Elizabeth D Thompson, David J Hackam, John L Cameron, Daniel S Rhee
Solid pseudopapillary neoplasms (SPNs) are the most common pediatric pancreatic tumor; however, most data in children are extrapolated from adults. This study describes a young presentation of SPN in a 5-year-old girl and presents a comprehensive systematic review of the literature regarding SPNs in children. A systematic review was performed using PubMed and Embase for all articles in English using predetermined search terms, including "solid pseudopapillary neoplasm" and "pediatric" and historical terms for SPN...
November 2018: Pancreas
https://www.readbyqxmd.com/read/30325865/chromogranin-a-in-the-follow-up-of-gastroenteropancreatic-neuroendocrine-neoplasms-is-it-really-game-over-a-systematic-review-and-meta-analysis
#5
Roberta Elisa Rossi, Clorinda Ciafardini, Valentina Sciola, Dario Conte, Sara Massironi
OBJECTIVES: Little is known about chromogranin A (CgA) during follow-up of gastroenteropancreatic neuroendocrine neoplasms. We hypothesized that serial CgA monitoring might be useful for the assessment of tumor progression, and we performed a systematic review of the literature and meta-analysis. METHODS: A bibliographical search was performed in PubMed using "chromogranin A" and "neuroendocrine tumors" and "follow-up" and "biomarker" to identify all pertinent articles published in the last 10 years...
November 2018: Pancreas
https://www.readbyqxmd.com/read/30325864/a-prospective-study-to-establish-a-new-onset-diabetes-cohort-from-the-consortium-for-the-study-of-chronic-pancreatitis-diabetes-and-pancreatic-cancer
#6
Anirban Maitra, Ayush Sharma, Randall E Brand, Stephen K Van Den Eeden, William E Fisher, Phil A Hart, Steven J Hughes, Kieren J Mather, Stephen J Pandol, Walter G Park, Ziding Feng, Jose Serrano, Jo Ann S Rinaudo, Sudhir Srivastava, Suresh T Chari
The National Cancer Institute and the National Institute for Diabetes and Digestive and Kidney Diseases initiated the Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC) in 2015 (the CPDPC's origin, structure, governance, and research objectives are described in another article in this journal). One of the key objectives of CPDPC is to assemble a cohort of 10,000 subjects 50 years or older with new-onset diabetes, called the NOD cohort. Using a define, enrich, and find early detection approach, the aims of the NOD study are to (a) estimate the 3-year probability of pancreatic ductal adenocarcinoma (PDAC) in NOD (define), (b) establish a biobank of clinically annotated biospecimens from presymptomatic PDAC and control new-onset type 2 diabetes mellitus subjects, (c) conduct phase 3 validation studies of promising biomarkers for identification of incident PDAC in NOD patients (enrich), and (d) provide a platform for development of a future interventional screening protocol for early detection of PDAC in patients with NOD that incorporates imaging studies and/or clinical algorithms (find)...
November 2018: Pancreas
https://www.readbyqxmd.com/read/30325863/evaluation-of-a-mixed-meal-test-for-diagnosis-and-characterization-of-pancreatogenic-diabetes-secondary-to-pancreatic-cancer-and-chronic-pancreatitis-rationale-and-methodology-for-the-detect-study-from-the-consortium-for-the-study-of-chronic-pancreatitis-diabetes
#7
Phil A Hart, Dana K Andersen, Kieren J Mather, Alicia C Castonguay, Mandeep Bajaj, Melena D Bellin, David Bradley, Noemy Contreras, Aida Habtezion, Murray Korc, Yogish Kudva, Maxim S Petrov, David C Whitcomb, Dhiraj Yadav, Ying Yuan, Jo Ann S Rinaudo, Sudhir Srivastava, Jose Serrano, Mark O Goodarzi
Pancreatogenic diabetes mellitus is most commonly the result of chronic pancreatitis but can also occur secondary to pancreatic cancer. The early identification of pancreatogenic diabetes and distinction from the more prevalent type 2 diabetes are clinically significant; however, currently, there is no validated method to differentiate these diabetes subtypes. We describe a study, "Evaluation of a Mixed Meal Test for Diagnosis and Characterization of PancrEaTogEniC DiabeTes Secondary to Pancreatic Cancer and Chronic Pancreatitis: the DETECT study," that seeks to address this knowledge gap...
November 2018: Pancreas
https://www.readbyqxmd.com/read/30325862/prospective-evaluation-of-chronic-pancreatitis-for-epidemiologic-and-translational-studies-rationale-and-study-design-for-proceed-from-the-consortium-for-the-study-of-chronic-pancreatitis-diabetes-and-pancreatic-cancer
#8
Dhiraj Yadav, Walter G Park, Evan L Fogel, Liang Li, Suresh T Chari, Ziding Feng, William E Fisher, Christopher E Forsmark, Christie Y Jeon, Aida Habtezion, Phil A Hart, Steven J Hughes, Mohamed O Othman, Jo Ann S Rinaudo, Stephen J Pandol, Temel Tirkes, Jose Serrano, Sudhir Srivastava, Stephen K Van Den Eeden, David C Whitcomb, Mark Topazian, Darwin L Conwell
Prospective Evaluation of Chronic Pancreatitis for Epidemiologic and Translational Studies (PROCEED) is the first prospective, observational cohort study of chronic pancreatitis (CP) in the United States. The primary goals of PROCEED are to define disease progression, test the predictive capability of candidate biomarkers, and develop a platform to conduct translational and mechanistic studies in CP. Using objective and consensus-driven criteria, PROCEED will enroll adults at different stages of CP-controls, suspected CP, and definite CP...
November 2018: Pancreas
https://www.readbyqxmd.com/read/30325861/international-study-group-of-pediatric-pancreatitis-in-search-for-a-cure-cohort-study-design-and-rationale-for-insppire-2-from-the-consortium-for-the-study-of-chronic-pancreatitis-diabetes-and-pancreatic-cancer
#9
Aliye Uc, Emily R Perito, John F Pohl, Uzma Shah, Maisam Abu-El-Haija, Bradley Barth, Melena D Bellin, Kate M Ellery, Douglas S Fishman, Cheryl E Gariepy, Matthew J Giefer, Tanja Gonska, Melvin B Heyman, Ryan W Himes, Sohail Z Husain, Asim Maqbool, Maria R Mascarenhas, Brian A McFerron, Veronique D Morinville, Tom K Lin, Quin Y Liu, Jaimie D Nathan, Sue J Rhee, Chee Y Ooi, Zachary M Sellers, Sarah Jane Schwarzenberg, Jose Serrano, David M Troendle, Steven L Werlin, Michael Wilschanski, Yuhua Zheng, Ying Yuan, Mark E Lowe
We created the INternational Study Group of Pediatric Pancreatitis: In Search for a CuRE (INSPPIRE 2) cohort to study the risk factors, natural history, and outcomes of pediatric acute recurrent pancreatitis and chronic pancreatitis (CP). Patient and physician questionnaires collect information on demographics, clinical history, family and social history, and disease outcomes. Health-related quality of life, depression, and anxiety are measured using validated questionnaires. Information entered on paper questionnaires is transferred into a database managed by Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer's Coordinating and Data Management Center...
November 2018: Pancreas
https://www.readbyqxmd.com/read/30325860/standard-operating-procedures-for-biospecimen-collection-processing-and-storage-from-the-consortium-for-the-study-of-chronic-pancreatitis-diabetes-and-pancreatic-cancer
#10
William E Fisher, Zobeida Cruz-Monserrate, Amy L McElhany, Gregory B Lesinski, Phil A Hart, Ria Ghosh, George Van Buren, Douglas S Fishman, Jo Ann S Rinaudo, Jose Serrano, Sudhir Srivastava, Thomas Mace, Mark Topazian, Ziding Feng, Dhiraj Yadav, Stephen J Pandol, Steven J Hughes, Robert Y Liu, Emily Lu, Robert Orr, David C Whitcomb, Amer S Abouhamze, Hanno Steen, Zachary M Sellers, David M Troendle, Aliye Uc, Mark E Lowe, Darwin L Conwell
High-quality and well-annotated biorepositories are needed to better understand the pathophysiology and biologic mechanisms of chronic pancreatitis (CP) and its consequences. We report a methodology for the development of a robust standard operating procedure (SOP) for a biorepository based on the experience of the clinical centers within the consortium to study Chronic Pancreatitis, Diabetes and Pancreas Cancer Clinical Centers (CPDPC), supported by the National Cancer Institute and the National Institute for Diabetes and Digestive and Kidney Diseases as a unique multidisciplinary model to study CP, diabetes, and pancreatic cancer in both children and adults...
November 2018: Pancreas
https://www.readbyqxmd.com/read/30325859/consortium-for-the-study-of-chronic-pancreatitis-diabetes-and-pancreatic-cancer-from-concept-to-reality
#11
Jose Serrano, Dana K Andersen, Christopher E Forsmark, Stephen J Pandol, Ziding Feng, Sudhir Srivastava, Jo Ann S Rinaudo
Research progress in diseases of the exocrine pancreas [chronic pancreatitis (CP), pancreatogenic diabetes mellitus, and pancreatic cancer] has been hampered by the disorders' heterogeneity, the limitations of previous small cross-sectional studies, the inability to safely obtain pancreatic tissue for study, and the lack of structured epidemiology tools, genetic testing, and biomarker development. Mechanism-based research of these diseases has suffered from the lack of systematically collected clinical measures in longitudinal cohort studies linked with biospecimens...
November 2018: Pancreas
https://www.readbyqxmd.com/read/30325858/accelerating-the-drug-delivery-pipeline-for-acute-and-chronic-pancreatitis-summary-of-the-working-group-on-drug-development-and-trials-in-chronic-pancreatitis-at-the-national-institute-of-diabetes-and-digestive-and-kidney-diseases-workshop
#12
Christopher E Forsmark, Dana K Andersen, John T Farrar, Megan Golden, Aida Habtezion, Sohail Z Husain, Liang Li, Julia Mayerle, Stephen J Pandol, Aliye Uc, Zixi Zhu, Dhiraj Yadav
The lack of effective therapeutic agents specifically tailored for chronic pancreatitis (CP) has hampered clinical care and negatively impacted patients' lives. New mechanistic insights now point to novel therapies, which involve both recently developed and/or repurposed agents. This working group focused on 2 main outcomes for CP: pain and progression of disease. The goal is to frame the essential aspects of trial design including patient-centered outcomes, proposed methods to measure the outcomes of pain and progression, and study design considerations for future trials to facilitate rapid drug development for patients with CP...
November 2018: Pancreas
https://www.readbyqxmd.com/read/30325857/accelerating-the-drug-delivery-pipeline-for-acute-and-chronic-pancreatitis-summary-of-the-working-group-on-drug-development-and-trials-in-recurrent-acute-pancreatitis-at-the-national-institute-of-diabetes-and-digestive-and-kidney-diseases-workshop
#13
Mark E Lowe, Marc T Goodman, Gregory A Coté, Marshall J Glesby, Mark Haupt, Nicholas J Schork, Vikesh K Singh, Dana K Andersen, Stephen J Pandol, Aliye Uc, David C Whitcomb
Recurrent acute pancreatitis (RAP) is a complex clinical syndrome with significant morbidity, unpredictable outcomes, and limited treatment options. The National Institute of Diabetes and Digestive and Kidney Disease sponsored a workshop on July 25, 2018, in Pittsburgh, Pennsylvania, to address research gaps impeding development of effective therapies for pancreatitis. The RAP working group identified challenges to clinical progress using existing definitions, risk assessment, diagnostic and severity criteria, disease trajectories, outcomes, and research methods...
November 2018: Pancreas
https://www.readbyqxmd.com/read/30325856/accelerating-the-drug-delivery-pipeline-for-acute-and-chronic-pancreatitis-summary-of-the-working-group-on-drug-development-and-trials-in-acute-pancreatitis-at-the-national-institute-of-diabetes-and-digestive-and-kidney-diseases-workshop
#14
Maisam Abu-El-Haija, Anna S Gukovskaya, Dana K Andersen, Timothy B Gardner, Peter Hegyi, Stephen J Pandol, Georgios I Papachristou, Ashok K Saluja, Vikesh K Singh, Aliye Uc, Bechien U Wu
A workshop was sponsored by the National Institute of Diabetes and Digestive and Kidney Diseases to focus on research gaps and opportunities on drug development for pancreatitis. This conference was held on July 25, 2018, and structured into 3 working groups (WG): acute pancreatitis (AP) WG, recurrent AP WG, and chronic pancreatitis WG. This article reports the outcome of the work accomplished by the AP WG to provide the natural history, epidemiology, and current management of AP; inform about the role of preclinical models in therapy selection; and discuss clinical trial designs with clinical and patient-reported outcomes to test new therapies...
November 2018: Pancreas
https://www.readbyqxmd.com/read/30325855/accelerating-the-drug-delivery-pipeline-for-acute-and-chronic-pancreatitis-knowledge-gaps-and-research-opportunities-overview-summary-of-a-national-institute-of-diabetes-and-digestive-and-kidney-diseases-workshop
#15
Aliye Uc, Dana K Andersen, Drucy Borowitz, Marshall J Glesby, Julia Mayerle, Robert Sutton, Stephen J Pandol
A workshop was sponsored by the Division of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, on July 25, 2018, in Pittsburgh, Penn. The workshop was designed to bring together a multidisciplinary group of experts to accelerate the development of therapeutics for clinical application in inflammatory diseases of the exocrine pancreas. Three separate working groups (acute pancreatitis, recurrent acute pancreatitis, and chronic pancreatitis) were formed to address the needs, gaps, and opportunities...
November 2018: Pancreas
https://www.readbyqxmd.com/read/30325854/the-agenda-for-accelerating-pancreatic-research
#16
Dana K Andersen, Christopher E Forsmark, Stephen J Pandol
No abstract text is available yet for this article.
November 2018: Pancreas
https://www.readbyqxmd.com/read/30325853/intercepting-pancreatic-cancer-our-dream-team-s-resolve-to-stop-pancreatic-cancer
#17
Michael G Goggins, Scott M Lippman, Pamela E Constantinou, Tyler Jacks, Gloria M Petersen, Sapna Syngal, Anirban Maitra
No abstract text is available yet for this article.
November 2018: Pancreas
https://www.readbyqxmd.com/read/30325852/2018-american-pancreatic-association-presidential-address-grateful-reflections
#18
Darwin L Conwell
No abstract text is available yet for this article.
November 2018: Pancreas
https://www.readbyqxmd.com/read/30308537/natural-history-of-small-pancreatic-lesions-suspected-to-be-nonfunctioning-pancreatic-neuroendocrine-tumors
#19
Jin Ho Choi, Young Hoon Choi, Jinwoo Kang, Woo Hyun Paik, Sang Hyub Lee, Ji Kon Ryu, Yong-Tae Kim
OBJECTIVES: Nonfunctioning pancreatic neuroendocrine tumors (NF-PNETs) are a rare disease but have been diagnosed more frequently than before. The aim of this study was to evaluate the natural course of small NF-PNETs. METHODS: We performed a retrospective analysis of patients with incidentally found small NF-PNETs (<20 mm) from 1999 to 2015. The patients who were recommended surveillance were included. RESULTS: There were 69 patients with small NF-PNETs with a mean size of 10...
November 2018: Pancreas
https://www.readbyqxmd.com/read/30308536/clinical-characteristics-and-genetic-causes-of-infantile-exocrine-pancreatic-insufficiency-in-chinese-patients-study-from-a-tertiary-care-center
#20
Ziqing Ye, Ying Zhou, Ying Huang, Hua Sun, Huijun Wang, Bingbing Wu
OBJECTIVE: Infantile exocrine pancreatic insufficiency is a rare disease. We examined phenotypes and performed genetic sequencing in children with this disorder. METHODS: We enrolled 4 infants with exocrine pancreatic insufficiency. Patients were characterized by phenotypes and radiologic findings. Genetic sequencing was performed. RESULTS: Average age of disease onset was 2 months. Average (standard deviation [SD]) age at diagnosis was 11...
November 2018: Pancreas
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