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Melena D Bellin, Polina Prokhoda, James S Hodges, Sarah J Schwarzenberg, Martin L Freeman, Ty B Dunn, Joshua J Wilhelm, Timothy L Pruett, Varvara A Kirchner, Gregory J Beilman, Srinath Chinnakotla
OBJECTIVES: We investigated the impact of patient age and disease duration on islet isolation results, diabetes outcomes, and pain outcomes after total pancreatectomy with islet autotransplant (TPIAT) performed in 64 patients with hereditary pancreatitis due to PRSS1 gene mutation. METHODS: We evaluated the association of patient age and disease duration on islet isolation results and opioid use at 1 year using logistic regression and on graft function using 1-way analysis of variance...
March 6, 2018: Pancreas
Aoi Hayasaki, Yasuhiro Murata, Masanobu Usui, Taemi Hibi, Takahiro Ito, Yusuke Iizawa, Hiroyuki Kato, Akihiro Tanemura, Yoshinori Azumi, Naohisa Kuriyama, Masashi Kishiwada, Shugo Mizuno, Hiroyuki Sakurai, Toshimichi Yoshida, Shuji Isaji
OBJECTIVES: Tenascin-C (TN-C) is an extracellular matrix protein that is up-regulated in pancreatic ductal adenocarcinoma (PDAC) stroma and associated with tumor invasion. We examined intratumor stromal expression of TN-C in resected specimens and the histologic effect of chemoradiotherapy (CRT) as prognostic indicators in initially locally advanced unresectable (UR-LA) PDAC. METHODS: Among 110 UR-LA PDAC patients enrolled in the CRT protocol from February 2005 to December 2015, 46 who underwent curative-intent resection were classified as high (tumor destruction >50%) and low (≤50%) responders according to the Evans grading system...
March 6, 2018: Pancreas
Barbara J Kenner
No abstract text is available yet for this article.
March 1, 2018: Pancreas
Tetsuya Nakazato, Yutaka Suzuki, Ryota Tanaka, Nobutsugu Abe, Tadahiko Masaki, Toshiyuki Mori, Yasuo Ohkura, Masanori Sugiyama
OBJECTIVES: Reprimo gene is a cytoplasmic protein belonging to a family of molecules controlled by p53 that inhibits cell cycle progression. Ectopic expression of Reprimo results in cell cycle arrest at the G2 phase. The aim of this study was to investigate the impact of Reprimo expression on tumorigenesis of intraductal papillary mucinous neoplasm (IPMN). METHODS: Thirty-seven surgical cases of IPMN were collected retrospectively. Twenty-eight patients had benign IPMNs (low-grade dysplasia, n = 18; intermediate-grade dysplasia, n = 10), and the remaining 9 had malignant IPMNs (high-grade dysplasia, n = 4; invasive carcinoma, n = 5)...
February 2, 2018: Pancreas
Matthieu Faron, Hélène Vuarnesson, Jean-Marie Boher, Philippe Bachellier, Alain Sauvanet, Antonio Sa Cunha, Yves-Patrice Le Treut, Jean-Yves Mabrut, Jean-Robert Delpero, François Paye
OBJECTIVES: The optimal number of lymph nodes that need to be analyzed to reliably assess nodal status in distal pancreatectomy for adenocarcinoma is still unknown. METHODS: Two hundred seventy-eight patients who underwent distal pancreatectomy for adenocarcinoma were retrieved from a retrospective French nationwide database. The relations between the number of analyzed lymph nodes and the nodal status of the tumor were studied. The beta-binomial law was used to estimate the probability of being truly node negative depending on the number of analyzed lymph nodes...
January 18, 2018: Pancreas
Prejesh Philips, David A Kooby, Shishir Maithel, Nipun B Merchant, Sharon M Weber, Emily R Winslow, Syed Ahmad, Hong J Kim, Charles R Scoggins, Kelly M McMasters, Robert C G Martin
OBJECTIVES: To measure the usefulness of Ki-67 proliferative index (Ki-67 index) as a prognostic variable for grading pancreatic neuroendocrine tumors. METHODS: A multi-institutional prospective database comprising 350 patients. Grading based on mitotic activity (<2 mitoses/10 high-power fields, 2-20 and >20) and Ki-67 index (<3% per 10 high-power fields, 3%-20% and >20%). Final grade selected based on higher grade of either variable. RESULTS: Most patients were in the less than 3% (n = 158) and 3% to 20% Ki-67 category (n = 107), with a minority being high-grade (Ki-67 > 20%, n = 27)...
January 18, 2018: Pancreas
Xianbin Zhang, Lili Lu, Peng Liu, Fei Cao, Yushan Wei, Li Ma, Peng Gong
OBJECTIVES: We aim to examine the predictive effect of the total number of examined lymph nodes on N stage and survival in pancreatic neuroendocrine neoplasms (pNENs) and to determine the optimal threshold. METHODS: A pNENs data set from 2004 to 2013 was extracted from the Surveillance, Epidemiology, and End Result database. Multivariate logistic regression and Cox proportional hazards model were used to identify predictive factors associated with N stage and survival, respectively...
January 12, 2018: Pancreas
Ozkan Balcin, Secil Ak Aksoy, Berrin Tunca, Ekrem Kaya, Unal Egeli, Gulcin Tezcan, Nesrin Ugras, Gulsah Cecener, Ozgen Isik, Halit Ziya Dundar, Omer Yerci
OBJECTIVES: Periampullary region tumors (PRTs) are the fifth highest cause of cancer-related deaths worldwide. Although recent studies have highlighted the prognostic value of the long noncoding RNA HomeboxA transcript at the distal tip (HOTTIP) in patients with pancreatic ductal adenocarcinoma, the relationship between HOTTIP and clinical outcome of all PRTs remains obscure. The aim of this study was to clarify the prognostic significance of HOTTIP in patients with all PRTs related to KRAS mutational status...
January 12, 2018: Pancreas
Dawood Khan, Srividya Vasu, R Charlotte Moffett, Nigel Irwin, Peter R Flatt
OBJECTIVES: Modulation of cholecystokinin (CCK) receptors has been shown to influence pancreatic endocrine function. METHODS: We assessed the impact of the CCKA and CCKB receptor modulators, (pGlu-Gln)-CCK-8 and gastrin-17, respectively, on β-cell secretory function, proliferation and apoptosis and glucose tolerance, and investigating alterations of CCK and gastrin islet expression in diabetes. RESULTS: Initially, the presence of CCK and gastrin, and expression of their receptors were evidenced in β-cell lines and mouse islets...
January 12, 2018: Pancreas
Joseph M Herman, Salma K Jabbour, Steven H Lin, Matthew P Deek, Charles C Hsu, Elliot K Fishman, Sinae Kim, John L Cameron, Marina Chekmareva, Daniel A Laheru, Amol K Narang, Timothy M Pawlik, Ralph H Hruban, Christopher L Wolfgang, Christine A Iacobuzio-Donahue
OBJECTIVES: The tumor suppressor gene SMAD4 (DPC4) is genetically inactivated in approximately half of pancreatic ductal adenocarcinomas (PDAs). We examined whether Smad4 tumor status was associated with outcomes after adjuvant chemoradiation (CRT) for resected PDAs. METHODS: Patients treated with adjuvant CRT were identified (N = 145). Smad4 status was determined by immunolabeling and graded as intact or lost. Kaplan-Meier method and multivariable competing risk analyses were performed...
January 12, 2018: Pancreas
Jonathan I Chang, Brian Z Huang, Bechien U Wu
OBJECTIVES: The objective of this study was to evaluate whether disparities in pancreatic cancer diagnosis, treatment, and survival are reduced in an integrated health system. METHODS: We conducted a retrospective study (2006-2014) among patients with pancreatic cancer from Kaiser Permanente Southern California. Racial ethnic groups included non-Hispanic whites (NHW), non-Hispanic blacks (NHB), Hispanics, and Asians. We used multivariable and Cox regression analyses to evaluate disparities in diagnosis and treatment utilization (oncology care, surgery, time to surgery, chemotherapy) and overall survival, respectively...
January 12, 2018: Pancreas
Peter Yu, Ka Liu, Xuxia Gao, Harry Karmouty-Quintana, Jennifer M Bailey, Yanna Cao, Tien C Ko
OBJECTIVES: To investigate regulation of microRNA (miR)-200 family (a, b, c, 141, and 429) in chronic pancreatitis (CP). This was accomplished by examining miR-200 family levels in a mouse model in vivo and their regulation in pancreatic cells in vitro. METHODS: Chronic pancreatitis was induced by cerulein for 4 weeks (50 μg/kg, 5 hourly intraperitoneal injections/day, and 3 days/week). Control mice received normal saline. The pancreata were harvested for fibrosis assessment by Sirius red staining and for miRNA, collagen, and fibronectin levels by quantitative PCR...
January 5, 2018: Pancreas
Céline Tiffon
OBJECTIVES: N-myc downstream-regulated gene-1 (NDRG1) is a hypoxia-inducible and differentiation-related protein and candidate biomarker in pancreatic cancer. As NDRG1 expression is lost in high-grade tumors, the effects of the differentiating histone deacetylase inhibitor trichostatin A (TSA) were examined in human pancreatic cancer cell lines representing different tumor grades. METHODS: PANC-1 (poorly differentiated) and Capan-1 (moderately to well differentiated) cells were treated with TSA...
January 5, 2018: Pancreas
Xiaoyue Jia, Peiling Du, Kusheng Wu, Zhenxi Xu, Jiaying Fang, Xiaoling Xu, Kun Lin
OBJECTIVES: During the last decade, the mortality rate of pancreatic cancer in China has significantly increased. We analyzed data for the period 1991-2014 to investigate the distribution of mortality rates and predict trends for the next 5 years. METHODS: We obtained the pancreatic mortality data from the Chinese cancer annual report. Trend surface analysis was applied to study the geographical distribution. We used curve estimation, time series, gray modeling, and joinpoint regression to predict the mortality rate...
January 5, 2018: Pancreas
Sumaira Rashid, Nidhi Singh, Surabhi Gupta, Safoora Rashid, Nandini Nalika, Vikas Sachdev, Chandra Sekhar Bal, Siddhartha Datta Gupta, Shyam S Chauhan, Anoop Saraya
OBJECTIVES: Early detection of pancreatic ductal adenocarcinoma still remains a challenge. Patients with chronic pancreatitis (CP) have a markedly increased risk of pancreatic cancer. Mutations in oncogenes and/or tumor suppressor genes play a role in development of pancreatic ductal adenocarcinoma. This study assessed mutations in KRAS and p53 gene in blood as a screening tool for malignant transformation in CP patients. METHODS: This was a cohort, single-center study including 294 CP patients...
January 5, 2018: Pancreas
Tina Boortalary, Niloofar Y Jalaly, Robert A Moran, Martin A Makary, Christi Walsh, Anne Marie Lennon, Atif Zaheer, Vikesh K Singh
No abstract text is available yet for this article.
April 2018: Pancreas
Ziad Kanaan, Allison Zhang, Kirthi Lilley, Milton Mutchnick
No abstract text is available yet for this article.
April 2018: Pancreas
Margherita Lorusso, Frediano Inzani, Paola Castaldi, Roberta Menghi, Giovanni Schinzari, Guido Rindi, Vittoria Rufini
No abstract text is available yet for this article.
April 2018: Pancreas
Ragini Kilambi, Anand Narayan Singh, Prasenjit Das, Kumble Seetharama Madhusudhan, Sujoy Pal
No abstract text is available yet for this article.
April 2018: Pancreas
Hari K V S Kumar, Saroj K Patnaik
No abstract text is available yet for this article.
April 2018: Pancreas
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