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Pancreas

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https://www.readbyqxmd.com/read/29771767/risk-of-postendoscopic-retrograde-cholangiopancreatography-pancreatitis-after-double-guidewire-biliary-cannulation-in-an-average-risk-population
#1
Joseph T Krill, Tomas DaVee, Jade S Edwards, J Chris Slaughter, Patrick S Yachimski
OBJECTIVES: Double-guidewire cannulation (DGC) for selective biliary access has been associated with increased risk of post-ERCP pancreatitis (PEP) in patients who have had pancreatic duct (PD) contrast injection. The objective of this study was to determine whether DGC increases PEP risk in standard risk individuals when controlling for procedural aspects such as PD contrast injection. METHODS: Consecutive adults with native papillae who underwent endoscopic retrograde cholangiopancreatography from 2009 to 2014 were retrospectively identified, and clinical data were collected...
May 17, 2018: Pancreas
https://www.readbyqxmd.com/read/29771766/prevalence-of-extrapancreatic-malignancies-among-patients-with-intraductal-papillary-mucinous-neoplasms-of-the-pancreas
#2
Nikola Panic, Federico Macchini, Sonia Solito, Stefania Boccia, Emanuele Leoncini, Alberto Larghi, Debora Berretti, Sara Pevere, Salvatore Vadala, Marco Marino, Maurizio Zilli, Milutin Bulajic
OBJECTIVES: We conducted a study in order to assess the prevalence of extrapancreatic malignancies (EPMs) in a cohort of patients with intraductal papillary mucinous neoplasms (IPMNs) from northeast of Italy. METHODS: A study was conducted in hospital Santa Maria della Misericordia, Udine, Italy. Hospital records were screened in order to identify newly diagnosed IPMN cases in the period from January 1, 2009, to December 31, 2015. We searched for EPMs diagnosed previous to, synchronous to, or after the IPMN...
May 17, 2018: Pancreas
https://www.readbyqxmd.com/read/29771765/comparison-of-fasting-human-pancreatic-polypeptide-levels-among-patients-with-pancreatic-ductal-adenocarcinoma-chronic-pancreatitis-and-type-2-diabetes-mellitus
#3
Sajan Jiv Singh Nagpal, William R Bamlet, Yogish C Kudva, Suresh T Chari
OBJECTIVES: Human pancreatic polypeptide (HPP) is a hormone secreted by the ventral pancreas. While postprandial HPP levels have been studied in chronic pancreatitis (CP) and pancreatic ductal adenocarcinoma (PDAC), there are limited data on fasting HPP in these diseases. METHODS: Fasting serum HPP was measured in the following groups of patients: CP with diabetes mellitus (DM) (n = 16), CP without DM (n = 34), PDAC with new-onset DM (n = 50), PDAC without DM (n = 49), new-onset type 2 DM (n = 50), and controls without DM (n = 49)...
May 17, 2018: Pancreas
https://www.readbyqxmd.com/read/29771764/intestinal-fatty-acid-binding-protein-as-a-marker-of-necrosis-and-severity-in-acute-pancreatitis
#4
Juozas Kupčinskas, Rolandas Gedgaudas, Hannes Hartman, Tomi Sippola, Outi Lindström, Colin Johnson, Sara Regnér
OBJECTIVES: The aim of this study was to study intestinal fatty acid binding protein (i-FABP) as a potential biomarker in predicting severity of acute pancreatitis (AP). METHODS: In a prospective multicenter cohort study plasma levels of i-FABP were measured in 402 patients with AP. Severity of AP was determined based on the 1992 Atlanta Classification. RESULTS: Admission levels of plasma i-FABP were significantly higher in patients with pancreatic necrosis, in patients having systemic complications, in patients treated invasively, in patients treated in the intensive care unit, in patients with severe AP, and in deceased patients...
May 17, 2018: Pancreas
https://www.readbyqxmd.com/read/29771771/a-therapeutic-strategy-for-resectable-pancreatic-cancer-based-on-risk-factors-of-early-recurrence
#5
Hiroshi Kurahara, Kosei Maemura, Yuko Mataki, Masahiko Sakoda, Satoshi Iino, Yota Kawasaki, Takaaki Arigami, Shinichiro Mori, Yuko Kijima, Shinichi Ueno, Hiroyuki Shinchi, Shoji Natsugoe
OBJECTIVES: The aim of this study was to identify risk factors for early recurrence and assess the prognostic benefit of neoadjuvant therapy (NAT) for resectable pancreatic cancer. METHODS: Patients with radiographically resectable pancreatic cancer according to the National Comprehensive Cancer Network guidelines were enrolled. We regarded recurrence within 6 months after surgery as early recurrence. RESULTS: This study involved 115 patients (80 who underwent upfront surgery and 35 who received NAT)...
May 15, 2018: Pancreas
https://www.readbyqxmd.com/read/29771770/biliary-stenosis-and-gastric-outlet-obstruction-late-complications-after-acute-pancreatitis-with-pancreatic-duct-disruption
#6
Motokazu Sugimoto, David P Sonntag, Greggory S Flint, Cody J Boyce, John C Kirkham, Tyler J Harris, Sean M Carr, Brent D Nelson, Don A Bell, Joshua G Barton, L William Traverso
OBJECTIVES: Pancreatic duct disruption (PDD) after acute pancreatitis can cause pancreatic collections in the early phase and biliary stenosis (BS) or gastric outlet obstruction (GOO) in the late phase. We aimed to document those late complications after moderate or severe acute pancreatitis. METHODS: Between September 2010 and August 2014, 141 patients showed pancreatic collections on computed tomography. Percutaneous drainage was primarily performed for patients with signs or symptoms of uncontrolled pancreatic juice leakage...
May 15, 2018: Pancreas
https://www.readbyqxmd.com/read/29771769/systemic-chemotherapy-for-advanced-rare-pancreatic-histotype-tumors-a-retrospective-multicenter-analysis
#7
Oronzo Brunetti, Giuseppe Aprile, Paolo Marchetti, Enrico Vasile, Andrea Casadei Gardini, Mario Scartozzi, Sandro Barni, Sara Delfanti, Fernando De Vita, Francesco Di Costanzo, Michele Milella, Chiara Alessandra Cella, Rossana Berardi, Ivana Cataldo, Aldo Scarpa, Debora Basile, Federica Mazzuca, Giusi Graziano, Antonella Argentiero, Daniele Santini, Michele Reni, Stefano Cascinu, Nicola Silvestris
OBJECTIVES: Two issues were put forth by clinicians in the management of the advanced stages of rare variants of pancreatic ductal adenocarcinoma and other exocrine histotypes with peculiar clinical and pathological features: Do chemotherapy regimens recommended in pancreatic ductal adenocarcinoma patients have a clinical activity in rare pancreatic tumors? Or should other chemotherapy combinations be considered in this subset of patients? METHODS: We conducted a multicenter retrospective study that collected data from 2005 to 2016 at 14 Italian cancer centers with the aim to evaluate tumor response and time to progression for first- and second-line and overall survival...
May 15, 2018: Pancreas
https://www.readbyqxmd.com/read/29771768/high-density-infiltration-of-v-domain-immunoglobulin-suppressor-of-t-cell-activation-up-regulated-immune-cells-in-human-pancreatic-cancer
#8
Jinʼe Liu, Xiaoxue Xie, Chunxiao Xuan, Tingting Li, Lanlan Wang, Lianghong Teng, Jun Liu
V-domain immunoglobulin suppressor of T-cell activation (VISTA) is constitutively expressed in hematopoietic lineage and is highly up-regulated in tumor infiltrated myeloid cells and regulatory T cells in animal models. However, its expression in human pancreatic tumor microenvironment remains unknown. In this research, we aimed at the expression of VISTA in human pancreatic cancer samples. METHODS: We performed immunohistochemistry to determine VISTA expression in human pancreatic cancer samples...
May 15, 2018: Pancreas
https://www.readbyqxmd.com/read/29683978/antimicrobial-peptide-human-neutrophil-peptide-1-as-a-potential-link-between-chronic-inflammation-and-ductal-adenocarcinoma-of-the-pancreas
#9
Thomas Pausch, Sarah Adolph, Klaus Felix, Andrea S Bauer, Frank Bergmann, Jens Werner, Werner Hartwig
OBJECTIVES: Defensins are antimicrobial peptides playing a role in innate immunity, in epithelial cell regeneration, and in carcinogenesis of inflammation-triggered malignancies. We analyzed this role in pancreatic ductal adenocarcinoma (PDAC) in the context of its association with chronic pancreatitis (CP). METHODS: Human tissue of healthy pancreas, CP, and PDAC was screened for defensins by immunohistochemistry. Defensin α 1 (human neutrophil peptide 1 [HNP-1]) expression was validated using mass spectrometry and microarray analysis...
April 19, 2018: Pancreas
https://www.readbyqxmd.com/read/29683977/slco1b1-polymorphism-is-a-drug-response-predictive-marker-for-advanced-pancreatic-cancer-patients-treated-with-gemcitabine-s-1-or-gemcitabine-plus-s-1
#10
Yasunori Sato, Hideki Ueno, Tatsuya Ioka, Shinichi Ohkawa, Masafumi Ikeda, Tomotaka Shimamura, Akihito Tsuji, Yoshiaki Tsuchiya, Junji Furuse, Hiroshi Ishii, Ken Furuya, Haruo Iguchi, Yoshihiro Saito, Nahoko Kaniwa, Jun-Ichi Sawada, Hiromi Sakamoto, Akihiro Sekine, Takuji Okusaka, Teruhiko Yoshida
OBJECTIVES: The aim of this study was to evaluate the effects of single-nucleotide polymorphisms (SNPs) on advanced pancreatic cancer risk and overall survival (OS) in a candidate-gene approach. METHODS: Overall, 5438 SNPs in 219 candidate genes encoding several drug-metabolizing enzymes or transporters were analyzed. In the screening study, 3 SNPs were found associated with OS (P ≤ 0.0005). We validated these SNPs as part of the randomized phase 3 study (GEST study)...
April 19, 2018: Pancreas
https://www.readbyqxmd.com/read/29683976/activating-p2x7-receptors-increases-proliferation-of-human-pancreatic-cancer-cells-via-erk1-2-and-jnk
#11
Ji Hun Choi, Young Geon Ji, Jung Jae Ko, Han Jun Cho, Dong Hyeon Lee
OBJECTIVES: The aim of this study was to investigate the effects of the activated P2X7 receptors on the proliferation and growth of human pancreatic cancer cells. METHODS: Proliferation was measured by incorporating bromodeoxyuridine into pancreatic cancer cells, MIA PaCa-2 and HPAC. Expression of P2 receptors and signal molecules was examined using quantitative reverse transcription/polymerase chain reaction and/or Western blot. Proliferative effects of the P2X7 receptors in vivo were examined using a xenotransplant model of pancreatic cancer cell lines...
April 19, 2018: Pancreas
https://www.readbyqxmd.com/read/29683971/extracorporeal-shock-wave-lithotripsy-for-chronic-pancreatitis-patients-with-stones-after-pancreatic-surgery
#12
Dan Wang, Jun-Tao Ji, Lei Xin, Ya-Wei Bi, Jun Pan, Zhuan Liao, Ting-Ting Du, Jin-Huan Lin, Di Zhang, Xiang-Peng Zeng, Bo Ye, Wen-Bin Zou, Hui Chen, Ting Xie, Bai-Rong Li, Zhao-Hong Zheng, Zhao-Shen Li, Liang-Hao Hu
OBJECTIVES: The objective of this study was to evaluate the safety and efficacy of pancreatic extracorporeal shock wave lithotripsy (P-ESWL) in chronic pancreatitis (CP) patients with pancreatic stones after previous pancreatic surgery. METHODS: This is a single-center study prospectively conducted in pained CP patients undergoing P-ESWL. Patients with a pancreatic surgery history (PSH) were included in the PSH group, and patients without a PSH during the same period were assigned to the control group...
April 19, 2018: Pancreas
https://www.readbyqxmd.com/read/29683970/endoscopic-ultrasound-based-pancreatic-cancer-screening-of-high-risk-individuals-a-prospective-observational-trial
#13
Alexandra Gangi, Mokenge Malafa, Jason Klapman
OBJECTIVES: Pancreatic cancer (PC), a common cause of cancer death, is rarely diagnosed at an early stage. Early detection of PC may improve outcomes in affected patients. This study evaluated the utility of screening of high-risk individuals (HRIs) using an endoscopic ultrasound (EUS)-only approach to detect early malignant changes. METHODS: A prospective PC screening program for HRIs was opened in 2007. Fifty-eight patients have enrolled to date. Patients with normal EUS examinations underwent repeat EUS annually for 5 years...
April 19, 2018: Pancreas
https://www.readbyqxmd.com/read/29683968/functional-correlation-between-the-pancreas-and-the-small-intestine-in-humans-the-first-evaluation-using-a-newly-developed-enteroscopy
#14
Daijuro Hayashi, Yoshiki Hirooka, Hiroki Kawashima, Eizaburo Ohno, Takuya Ishikawa, Takamichi Kuwahara, Manabu Kawai, Takeshi Yamamura, Kazuhiro Furukawa, Kohei Funasaka, Masanao Nakamura, Ryoji Miyahara, Osamu Watanabe, Masatoshi Ishigami, Senju Hashimoto, Hidemi Goto
OBJECTIVES: The aim of this study is to evaluate a functional correlation between the pancreas and the small intestine and the association of this relationship with nutritional status, using magnifying enteroscopy. METHODS: The subjects were adults aged 20 years or older who underwent upper gastrointestinal endoscopy. An endoscope was inserted into the jejunum, and 10% glucose was sprayed under magnifying observation to evaluate changes in blood flow in the villous capillary network...
April 19, 2018: Pancreas
https://www.readbyqxmd.com/read/29683967/comparison-of-totally-3-dimensional-laparoscopic-pancreaticoduodenectomy-and-open-pancreaticoduodenectomy
#15
Hang Zhang, Xingjun Guo, Jia Xia, Feng Zhu, Ming Shen, Xin Wang, Min Wang, Renyi Qin
OBJECTIVE: The aim of this study was to evaluate the safety, feasibility, and oncologic outcomes of 3-dimensional total laparoscopic pancreaticoduodenectomy (3D-TLPD). METHODS: Data of all patients who underwent 3D-TLPD (n = 202) or open pancreaticoduodenectomy (OPD) (n = 213) at a single institution between October 2014 and December 2016 were reviewed. We evaluated the safety, feasibility, and oncologic outcomes of 3D-TLPD compared with OPD. RESULTS: The mean operative times in the 3D-TLPD and OPD groups were comparable (P = 0...
April 19, 2018: Pancreas
https://www.readbyqxmd.com/read/29621044/impact-of-oxygen-on-pancreatic-islet-survival
#16
Hirotake Komatsu, Fouad Kandeel, Yoko Mullen
Pancreatic islet transplantation is a promising treatment option for individuals with type 1 diabetes; however, maintaining islet function after transplantation remains a large challenge. Multiple factors, including hypoxia associated events, trigger pretransplant and posttransplant loss of islet function. In fact, islets are easily damaged in hypoxic conditions before transplantation including the preparation steps of pancreas procurement, islet isolation, and culture. Furthermore, after transplantation, islets are also exposed to the hypoxic environment of the transplant site until they are vascularized and engrafted...
April 4, 2018: Pancreas
https://www.readbyqxmd.com/read/29595544/luteolin-ameliorates-experimental-chronic-pancreatitis-induced-by-trinitrobenzenesulfonic-acid-in-rats
#17
Qiang Yu, Jianhong Zhu, Xiaolei Sheng, Limin Xu, Kewei Hu, Guilian Chen, Wei Wu, Wei Cai, Weichang Chen, Guojian Yin
OBJECTIVES: The purpose of this study is to assess the effect and possible mechanism of luteolin on chronic pancreatitis (CP). METHODS: Trinitrobenzenesulfonic acid-induced CP was used as CP models in vivo. After the intervention of luteolin for 28 days, chronic pancreatic injury was assessed by serum hydroxyproline and pancreatic histology. α-Smooth muscle actin (α-SMA) expression was performed to detect the activation of pancreatic stellate cells (PSCs). Pancreatic stellate cells were also isolated and cultured in vitro, and the effect of luteolin on PSCs was evaluated...
March 27, 2018: Pancreas
https://www.readbyqxmd.com/read/29595543/protective-effect-of-scopoletin-against-cerulein-induced-acute-pancreatitis-and-associated-lung-injury-in-mice
#18
George Leema, Ramasamy Tamizhselvi
OBJECTIVE: The present study aimed to evaluate the protective effects of scopoletin (SC) on cerulein-induced acute pancreatitis (AP) and associated lung injury in mice. METHODS: Acute pancreatitis was induced in male Swiss mice by 6 consecutive hourly intraperitoneal injections of cerulein (50 μg/kg). Scopoletin was administered 1 hour (intraperitoneal, 10 mg/kg) after the first cerulein injection. RESULTS: Administration of SC attenuated the severity of AP and associated lung injury as shown by histology, reduced myeloperoxidase, and serum amylase activity...
March 27, 2018: Pancreas
https://www.readbyqxmd.com/read/29702534/dakin-solution-for-irrigation-of-pancreatic-fluid-collections
#19
David H Ballard, Taylor M Morris, Horacio B DʼAgostino
No abstract text is available yet for this article.
May 2018: Pancreas
https://www.readbyqxmd.com/read/29702533/mouse-pancreatic-tumor-model-independent-of-tumor-suppressor-gene-inactivation
#20
Mayumi Naramura, Amarnath Natarajan
No abstract text is available yet for this article.
May 2018: Pancreas
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