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Chisaki Ishibashi, Junji Kozawa, Yukari Fujita, Sho Yoneda, Sae Uno, Takekazu Kimura, Kenji Fukui, Satoshi Nojima, Eiichi Morii, Hidetoshi Eguchi, Hiromi Iwahashi, Akihisa Imagawa, Iichiro Shimomura
No abstract text is available yet for this article.
July 11, 2018: Pancreas
Daigoro Takahashi, Motohiro Kojima, Motokazu Sugimoto, Shin Kobayashi, Shinichiro Takahashi, Masaru Konishi, Naoto Gotohda, Masato Nagino
OBJECTIVES: Processing of pancreatoduodenectomy specimens is not standardized; the clinical impact of pathologic surgical margins remains controversial. We used the color-coding method using tissue-marking dyes to evaluate margin status of resected specimens to assess its association with postoperative recurrence. METHODS: We developed a unified processing approach to assess pancreatoduodenectomy specimens. Five surgical margins of resected pancreatic specimens were marked with 5 colors...
July 3, 2018: Pancreas
Yoshiyasu Kato, Suguru Yamada, Masaya Suenaga, Hideki Takami, Yukiko Niwa, Masamichi Hayashi, Naoki Iwata, Mitsuro Kanda, Chie Tanaka, Goro Nakayama, Masahiko Koike, Michitaka Fujiwara, Yasuhiro Kodera
OBJECTIVES: The controlling nutritional status (CONUT) score is a useful tool to evaluate immune-nutritional status. This study aimed to investigate the impact of the CONUT score on short- and long-term outcomes after curative resection of pancreatic ductal adenocarcinoma (PDAC). METHODS: Consecutive 344 PDAC patients receiving pancreatectomy without neoadjuvant therapy were examined retrospectively. After the best predictive value of the CONUT score for survival was identified, association between the CONUT score and long-term outcomes was evaluated using log-rank tests and a Cox regression model...
July 3, 2018: Pancreas
David X Jin, Ronilda Lacson, Laila R Cochon, Emily C Alper, Julia McNabb-Baltar, Peter A Banks, Ramin Khorasani
OBJECTIVE: This study aimed to develop a diagnostic model that predicts acute pancreatitis (AP) risk before imaging. METHODS: Emergency department patients with serum lipase elevated to 3 times the upper limit of normal or greater were identified retrospectively (September 1, 2013-August 31, 2015). An AP diagnosis was established by expert review of full hospitalization records. Candidate predictors included demographic and clinical characteristics at presentation...
July 3, 2018: Pancreas
Jeff Choi, Jing Wang, Gang Ren, Avnesh S Thakor
OBJECTIVES: Endovascular techniques can now access the arterial blood supply of the pancreas in humans to enable therapeutics to reach the gland in high concentrations while concurrently avoiding issues related to non-targeted delivery. However, there is no way to replicate this in small animals. In a rat model, we therefore developed a novel non-terminal technique to deliver therapeutics to different regions of the pancreas, via its arterial blood supply. METHODS: In female Wistar rats, selective branches of the celiac artery were temporarily ligated, depending on the region of the pancreas being targeted...
July 3, 2018: Pancreas
Seungho Lee, Ho Kyoung Hwang, Chang Moo Kang, Woo Jung Lee
OBJECTIVES: Diabetes mellitus (DM) is prevalent with pancreatic ductal adenocarcinoma (PDAC). Importantly, new-onset DM is characteristic of the disease and could be an early sign of PDAC. The clinical outcome of PDAC with new-onset DM may differ from that in patients without DM or long-standing DM. METHODS: We retrospectively reviewed medical records of PDAC patients who underwent curative resection between 2006 and 2014. New-onset DM was defined as a diagnosis of DM within 24 months before the diagnosis of PDAC...
July 3, 2018: Pancreas
Xiang-Peng Zeng, Xing-Yi Zhu, Bai-Rong Li, Chun-Shu Pan, Lu Hao, Jun Pan, Dan Wang, Ya-Wei Bi, Jun-Tao Ji, Lei Xin, Zhuan Liao, Ting-Ting Du, Jin-Huan Lin, Di Zhang, Bo Ye, Wen-Bin Zou, Hui Chen, Ting Xie, Zhao-Hong Zheng, Zhao-Shen Li, Liang-Hao Hu
OBJECTIVES: The aim of this study was to establish a standard to describe the spatial distribution of pancreatic stones in chronic pancreatitis (CP). METHODS: Two hundred forty-seven CP patients with pancreatic stones from June to December 2012 were enrolled. Two-dimensional images from coronal projection of 3-dimensional computed tomography images of pancreatic stones were gained. The number (n) of all stones and the geometric standard deviation (σ) of distances between the centroid of all stones and the centroids of every stone that represented the spatial distribution nonuniformity were calculated by Stone Reconstruction and Identification Programming System...
July 3, 2018: Pancreas
Jami L Saloman, Aatur D Singhi, Douglas J Hartman, Daniel P Normolle, Kathryn M Albers, Brian M Davis
OBJECTIVES: In patients with pancreatic ductal adenocarcinoma (PDAC), increased expression of proinflammatory neurotrophic growth factors (eg, nerve growth factor [NGF]) correlates with a poorer prognosis, perineural invasion, and, with regard to NGF, pain severity. We hypothesized that NGF sequestration would reduce inflammation and disease in the KPC mouse model of PDAC. METHODS: Following biweekly injections of NGF antibody or control immunoglobulin G, beginning at 4 or 8 weeks of age, inflammation and disease stage were assessed using histological, protein expression, and quantitative polymerase chain reaction analyses...
July 3, 2018: Pancreas
Alexandra M Mueller, Christoph R Meier, Susan S Jick, Cornelia Schneider
OBJECTIVES: The aim of this study was to characterize the role of glycemic control and weight change as markers for pancreatic cancer (PaC) in patients with long-standing diabetes. METHODS: We conducted case-control analyses in patients with long-standing diabetes (>2 years) in the United Kingdom-based Clinical Practice Research Datalink. Cases were patients with PaC matched to control subjects on variables including age, sex, and diabetes duration. We compared glycated hemoglobin (HbA1c) levels, blood glucose levels, and weight change before cancer detection (matched date) between cases and control subjects to assess associations between the potential markers and PaC...
July 3, 2018: Pancreas
Eugene A Woltering, Brianne A Voros, Ramcharan Thiagarajan, David T Beyer, Robert A Ramirez, Yi-Zarn Wang, Gregg Mamikunian, J Philip Boudreaux
OBJECTIVES: Elevated neurokinin A (NKA) levels are associated with poor prognosis in patients with small bowel neuroendocrine tumors. We hypothesized that patients with NKA levels that remain elevated despite treatment with surgical cytoreduction have a poor prognosis. METHODS: Patients diagnosed with small bowel neuroendocrine tumors who underwent surgical cytoreduction at our institution were identified. Demographics, histopathologic characteristics, and biochemical data were collected...
June 23, 2018: Pancreas
Rupak Desai, Upenkumar Patel, Shobhit Sharma, Sandeep Singh, Shreyans Doshi, Sana Shaheen, Sofia Shamim, Lakshmi Shirisha Korlapati, Shuba Balan, Christopher Bray, Renee Williams, Nihar Shah
OBJECTIVES: The aim of this study was to assess the role of hepatitis B (HepB) infection in the causation of pancreatic cancer and the predictors of pancreatic cancer and related mortality. METHODS: We identified pancreatic cancer patients 11 to 70 years of age from the 2013-2014 National Inpatient Sample. Pearson χ test and Student t test were used for categorical and continuous variables, respectively. We assessed the association of HepB and pancreatic cancer along with the independent mortality predictors by multivariate analyses...
June 23, 2018: Pancreas
Tak Kyu Oh, Sang-Hwan Do, Yoo-Suk Yoon, In-Ae Song
OBJECTIVES: Patients with pancreatic cancer generally experience increasing pain as their disease progresses, making the titration of opioids difficult. This study aimed to determine a correlation between prescribed opioid doses and survival time in patients with unresectable pancreatic cancer. METHODS: This retrospective observational cohort study in a tertiary care institution reviewed the medical records of patients diagnosed with unresectable pancreatic cancer and treated over a 10-year period...
June 23, 2018: Pancreas
Tomasz Konończuk, Bartłomiej Łukaszuk, Agnieszka Mikłosz, Adrian Chabowski, Małgorzata Żendzian-Piotrowska, Krzysztof Kurek
OBJECTIVES: Acute pancreatitis (AP) is a common and severe gastrointestinal inflammatory disease with poorly understood pathogenesis. We adopted cerulein-induced pancreatitis, a well-established rat model shearing similarities with human AP, to determine the disease background. Special interest was placed on sphingolipids, because their signaling pathways are involved in many pathological states including hepatic steatosis, heart infarction, or pancreatic origin type 1 diabetes. METHODS: Sphingolipid levels in the blood and pancreas were determined by the means of chromatography (thin-layer and high-performance liquid chromatography)...
June 23, 2018: Pancreas
Qian Zhao, Xinyue Tang, Junhua Huang, Jiajia Li, Qinfen Chen, Yangjie Sun, Jiansheng Wu
OBJECTIVES: The objective of this study is to explore the effect of melatonin on endoplasmic reticulum stress in acute pancreatitis (AP) and the molecular mechanism. METHODS: Acute pancreatitis was induced in vivo in Sprague-Dawley rats by the retrograde injection of 5% taurocholate into the biliopancreatic duct and in vitro by treating AR42J cells with cerulein (10 nmol/L) plus lipopolysaccharide (LPS) (10 mg/L). The rats and cells were treated with melatonin (50 mg/kg in rats and 0...
June 16, 2018: Pancreas
Jennifer Phung Woo, Leigh Christopher Reardon, Martin Cadeiras
No abstract text is available yet for this article.
June 16, 2018: Pancreas
Maciej Sassek, Pawel A Kolodziejski, Mathias Z Strowski, Leszek Nogowski, Krzysztof W Nowak, Pawel Mackowiak
OBJECTIVES: Spexin is a peptide whose action is poorly understood but which is expressed in many tissues. This encouraged us to investigate the potential role of spexin in the regulation of pancreatic secretion. METHODS: Cells/islets were incubated with different concentrations of glucose and spexin to measure insulin secretion. MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assays and BrdU (5-bromo-2'-deoxyuridine) tests were performed to assess the viability and proliferation of pancreatic islets after spexin treatment...
June 16, 2018: Pancreas
Darin L Dufault, B Joseph Elmunzer, Peter B Cotton, April Williams, Gregory A Cote
OBJECTIVES: Pancreatic endoscopic sphincterotomy (PES) is an independent risk factor for short- and long-term adverse events (AEs) of endoscopic retrograde cholangiopancreatography. We sought to measure PES-specific AEs and trends in the use of PES. METHODS: This was a retrospective cohort of consecutive patients who underwent first-time PES between June 2008 and June 2015. Indications for PES were dichotomized: (1) structural pathology (chronic pancreatitis and local complications of acute pancreatitis) and (2) suspected sphincter pathology (idiopathic recurrent acute pancreatitis and sphincter of Oddi dysfunction)...
June 16, 2018: Pancreas
Xiaozheng Yu, Chunyun Li, Hechao Song, Xueyan Wang, Yinan Guo, Lijian Cui, Xiaoya Liu, Cheng Chi, Ruixia Liu, Chenghong Yin
OBJECTIVES: The aim of this study was to investigate the effects of emodin on attenuating autophagy response in acute pancreatitis (AP) models. METHODS: Acute pancreatitis was induced in Wistar rats by injecting 3% sodium taurocholate into the biliopancreatic duct. Emodin (40 mg/kg per day) was then given intragastrically, administrated 2 hours after AP induction. Rats were killed 24 hours after AP induction. The pancreatic injury was assessed using biochemical and histological approaches...
June 16, 2018: Pancreas
Eri Hamada, Nana Ebi, Chika Miyagi-Shiohira, Yoshihito Tamaki, Yoshiki Nakashima, Naoya Kobayashi, Issei Saitoh, Masami Watanabe, Takao Kinjo, Hirofumi Noguchi
No abstract text is available yet for this article.
August 2018: Pancreas
Hidetatsu Outani, Hirofumi Akita, Takaaki Nakai, Ryoji Takada, Yoshinori Imura, Takaaki Tanaka, Hironari Tamiya, Kazuya Oshima, Hidenori Takahashi, Kazuyoshi Ohkawa, Kazuhiro Katayama, Nobuhito Araki, Norifumi Naka
No abstract text is available yet for this article.
August 2018: Pancreas
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