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Pancreas

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https://www.readbyqxmd.com/read/28328615/patient-reported-experience-of-diagnosis-management-and-burden-of-neuroendocrine-tumors-results-from-a-large-patient-survey-in-the-united-states
#1
Edward M Wolin, John Leyden, Grace Goldstein, Teodora Kolarova, Ron Hollander, Richard R P Warner
OBJECTIVES: The aim of this survey was to examine the experience of patients with neuroendocrine tumors (NETs) to raise awareness of the NET-related burden and identify unmet needs. Here, we report data from patients in the United States. METHODS: Patients with NETs participated in a 25-minute anonymous survey, conducted primarily online from February to May 2014. Survey questions captured information on sociodemographics, clinical characteristics, NET diagnostic experience, disease impact/management, interaction with medical teams, and NETs knowledge/awareness...
March 21, 2017: Pancreas
https://www.readbyqxmd.com/read/28196023/the-more-the-better-lower-rate-of-stage-migration-and-better-survival-in-patients-with-retrieval-of-20-or-more-regional-lymph-nodes-in-pancreatic-cancer-a-population-based-propensity-score-matched-and-trend-seer-analysis
#2
Rene Warschkow, Bernhard Widmann, Ulrich Beutner, Lukas Marti, Thomas Steffen, Marc Schiesser, Bruno M Schmied
OBJECTIVE: The aim of this study was to assess the influence of regional lymph node (RLN) retrieval on stage migration and survival in pancreatic cancer. METHODS: A total of 7,685 stage I and II pancreatic cancer patients were identified in the Surveillance, Epidemiology, and End Results database in 2004-2011. The impact of RLN was assessed using Cox regression, propensity score methods, and joinpoint regression. RESULTS: In 3,079 patients, 1 to 10 RLNs were retrieved; in 2,799 patients, 11 to 19 RLNs, and in 1,807 patients, 20+ RLNs...
February 14, 2017: Pancreas
https://www.readbyqxmd.com/read/28196020/the-prevalence-and-clinicopathological-characteristics-of-high-grade-pancreatic-intraepithelial-neoplasia-autopsy-study-evaluating-the-entire-pancreatic-parenchyma
#3
Yoko Matsuda, Toru Furukawa, Shinichi Yachida, Makoto Nishimura, Atsuko Seki, Keisuke Nonaka, Junko Aida, Kaiyo Takubo, Toshiyuki Ishiwata, Wataru Kimura, Tomio Arai, Mari Mino-Kenudson
OBJECTIVE: We sought to identify clinicopathological characteristics of high-grade pancreatic intraepithelial neoplasia (PanIN)/carcinoma in situ to facilitate screening for pancreatic ductal adenocarcinoma. METHODS: We evaluated PanIN lesions in 173 consecutive autopsy cases with no evidence of pancreatic ductal adenocarcinoma and/or intraductal papillary mucinous neoplasm (mean age, 80.5 years) by submitting the entire pancreas for microscopic examination. RESULTS: PanIN-3 was found in 4% of examined cases, whereas PanIN-1 and PanIN-2 were present in 77% and 28%, respectively...
February 14, 2017: Pancreas
https://www.readbyqxmd.com/read/28196018/pancreatic-cancer-incidence-and-lethality-rates-in-brazil-an-ecological-study
#4
Lucila M Perrotta de Souza, Jessica P L Moreira, Homero S Fogaça, Ronir R Luiz, Heitor S de Souza
OBJECTIVES: To describe incidence and lethality time trends rates of pancreatic cancer (PC) in Brazil. METHODS: Data from Brazilian Health National Public System (SUS) were retrospectively collected with regard to PC from January 2005 to December 2012. Pancreatic cancer incidence and lethality rates were estimated from SUS hospitalizations and in-hospital PC deaths and adjusted to total available hospital beds. RESULTS: From 2005 to 2012, a total of 36,332 admissions for PC were registered in Brazil...
February 14, 2017: Pancreas
https://www.readbyqxmd.com/read/28196015/genomic-characterization-of-low-and-high-grade-pancreatic-mucinous-cystic-neoplasms-reveals-recurrent-kras-alterations-in-high-risk-lesions
#5
James R Conner, Adrián Mariño-Enríquez, Mari Mino-Kenudson, Elizabeth Garcia, Martha B Pitman, Lynette M Sholl, Amitabh Srivastava, Leona A Doyle
OBJECTIVES: Pancreatic ductal adenocarcinoma arises from the following 3 distinct precursor lesions: pancreatic intraepithelial neoplasia, intraductal papillary mucinous neoplasm, and mucinous cystic neoplasm (MCN). Genetic abnormalities in the first 2 precursor lesions have been well characterized, but there are limited data on progression pathways in MCNs. This study aimed to characterize genomic differences between MCNs with low-grade (LG) and high-grade (HG) dysplasia or carcinoma...
February 14, 2017: Pancreas
https://www.readbyqxmd.com/read/28196014/methylation-of-tumor-suppressor-genes-in-autoimmune-pancreatitis
#6
Yasuhiro Kinugawa, Takeshi Uehara, Kenji Sano, Kazuyuki Matsuda, Yasuhiro Maruyama, Yukihiro Kobayashi, Tomoyuki Nakajima, Hideaki Hamano, Shigeyuki Kawa, Kayoko Higuchi, Noriko Hosaka, Satoshi Shiozawa, Hiroki Ishigame, Hiroyoshi Ota
OBJECTIVES: Autoimmune pancreatitis (AIP) is a representative IgG4-related and inflammatory disease of unknown etiology. To clarify mechanisms of carcinogenesis resulting from AIP, we focused on methylation abnormalities and KRAS mutations in AIP. METHODS: Six tumor suppressor genes (NPTX2, Cyclin D2, FOXE1, TFPI2, ppENK, and p16) that exhibited hypermethylation in pancreatic carcinoma were selected for quantitative SYBR green methylation-specific polymerase chain reaction in 10 AIP specimens, 10 pancreatic adenocarcinoma cases without history of AIP containing carcinoma areas (CAs) and noncarcinoma areas (NCAs), and 11 normal pancreas (NP) samples...
February 14, 2017: Pancreas
https://www.readbyqxmd.com/read/28196013/prognostic-implications-of-expression-profiling-for-gemcitabine-related-genes-hent1-dck-rrm1-rrm2-in-patients-with-resectable-pancreatic-adenocarcinoma-receiving-adjuvant-chemotherapy
#7
Marek Sierzega, Radosław Pach, Piotr Kulig, Janusz Legutko, Jan Kulig
OBJECTIVES: The aim of this study was to examine the relevance of expression profiling of 4 genes involved in the action of gemcitabine among patients with pancreatic ductal-cell adenocarcinoma (PDAC). METHODS: A group of 100 patients who underwent pancreatic resections for PDAC and received adjuvant chemotherapy with gemcitabine between 2007 and 2010 was identified. Expression of mRNAs for human equilibrative nucleoside transporter 1 (hENT1), ribonucleotide reductase subunits (RRM1, RRM2), and deoxycytidine kinase (dCK) was examined by quantitative real-time polymerase chain reaction, normalized to glyceraldehyde-3-phosphate dehydrogenase (GAPDH), and dichotomized into groups of low and moderate/high expression levels grouped by tertiles...
February 14, 2017: Pancreas
https://www.readbyqxmd.com/read/28099259/smad2-3-linker-phosphorylation-is-a-possible-marker-of-pancreatic-stem-progenitor-cells-in-the-regenerative-phase-of-acute-pancreatitis
#8
Masayuki Sakao, Yutaku Sakaguchi, Ryo Suzuki, Yu Takahashi, Masanobu Kishimoto, Toshiro Fukui, Kazushige Uchida, Akiyoshi Nishio, Koichi Matsuzaki, Kazuichi Okazaki
OBJECTIVES: The aims of this study are to characterize cell proliferation and differentiation during regeneration after pancreatitis and pancreatic buds during development to evaluate the role of Smad2/3, phosphorylated at the specific linker threonine residues (pSmad2/3L-Thr) in positive cells. METHODS: Male C57BL/6 mice received hourly intraperitoneal injections of cerulein and were analyzed after induced pancreatitis. Pancreatitis-affected tissue sections and pancreatic buds were immunostained for pSmad2/3L-Thr, with other markers thought to be stem/progenitor markers of the pancreas...
January 18, 2017: Pancreas
https://www.readbyqxmd.com/read/28291166/increased-calcium-ion-levels-following-systemic-circulation-after-the-selective-arterial-calcium-injection-test
#9
Gentarou Egusa, Kenji Oki, Yoko Yoshii, Mitsunobu Kubota, Hirofumi Okubo, Haruya Ohno, Kenji Kajiwara, Kazuo Awai, Masayasu Yoneda
No abstract text is available yet for this article.
April 2017: Pancreas
https://www.readbyqxmd.com/read/28291165/preoperative-treatment-with-folfirinox-and-successful-resection-for-a-patient-with-mixed-acinar-endocrine-carcinoma-of-the-pancreas
#10
Motokazu Sugimoto, O Joe Hines, David W Dawson, V Raman Muthusamy, Howard A Reber, Timothy R Donahue
No abstract text is available yet for this article.
April 2017: Pancreas
https://www.readbyqxmd.com/read/28291164/severe-case-of-tumor-lysis-syndrome-presenting-spontaneously-in-a-metastatic-pancreatic-adenocarcinoma-patient
#11
Jalaluddin Umar, Aditya Kalakonda, Lauren Panebianco, Gurveen Kaur, Savio John
No abstract text is available yet for this article.
April 2017: Pancreas
https://www.readbyqxmd.com/read/28291163/prognostic-value-of-molecular-subtypes-in-pancreatic-cancer
#12
François Bertucci, David J Birnbaum, Pascal Finetti, Marine Gilabert, Flora Poizat, Jean-Luc Raoul, Daniel Birnbaum, Emilie Mamessier
No abstract text is available yet for this article.
April 2017: Pancreas
https://www.readbyqxmd.com/read/28291162/acute-bilateral-retinal-vasculitis-revealing-a-serotonin-secreting-neuroendocrine-neoplasm
#13
Grégory Pugnet, Vincent Soler, Léonardo Astudillo, Vincent Gualino
No abstract text is available yet for this article.
April 2017: Pancreas
https://www.readbyqxmd.com/read/28291161/development-of-the-nonobese-diabetic-mouse-and-contribution-of-animal-models-for-understanding-type-1-diabetes
#14
Yoko Mullen
In 1974, the discovery of a mouse and a rat that spontaneously developed hyperglycemia led to the development of 2 autoimmune diabetes models: nonobese diabetic (NOD) mouse and Bio-Breeding rat. These models have contributed to our understanding of autoimmune diabetes, provided tools to dissect autoimmune islet damage, and facilitated development of early detection, prevention, and treatment of type 1 diabetes. The genetic characterization, monoclonal antibodies, and congenic strains have made NOD mice especially useful...
April 2017: Pancreas
https://www.readbyqxmd.com/read/28291160/american-pancreatic-association-and-japan-pancreas-society-sisterhood-memorandum-of-understanding
#15
Vay Liang W Go, Tooru Shimosegawa, Ashok K Saluja, Anna R Fuchs, Tadashi Takeuchi
No abstract text is available yet for this article.
April 2017: Pancreas
https://www.readbyqxmd.com/read/28230660/diagnostic-performance-of-48-hour-fasting-test-and-insulin-surrogates-in-patients-with-suspected-insulinoma
#16
Keijiro Ueda, Ken Kawabe, Lingaku Lee, Yuichi Tachibana, Nao Fujimori, Hisato Igarashi, Yoshinao Oda, Robert T Jensen, Ryoichi Takayanagi, Tetsuhide Ito
OBJECTIVES: This study aimed to evaluate the usefulness of the 48-hour fasting test and insulin surrogates followed by a glucagon stimulatory test (GST) for the diagnosis of insulinoma. METHODS: Thirty-five patients with suspected insulinoma who underwent 48-hour fasting test and GST were retrospectively included in our study: 15 patients with surgically proven insulinomas and 20 patients in whom insulinoma was clinically ruled out. We determined the duration of the fasting test, plasma glucose levels, serum levels of immunoreactive insulin and C-peptide, and insulin surrogates (serum levels of β-hydroxybutyrate, free fatty acid, and response of plasma glucose to intravenous glucagon [ΔPG]) at the end of the fast...
April 2017: Pancreas
https://www.readbyqxmd.com/read/28230659/sulfonylurea-blockade-of-katp-channels-unmasks-a-distinct-type-of-glucose-induced-ca2-decrease-in-pancreatic-%C3%AE-cells
#17
Bo Hellman, Heléne Dansk, Eva Grapengiesser
OBJECTIVES: This study aimed to explore how sulfonylurea blockade of KATP channels affects the early Ca signals for glucose generation of insulin release. METHODS: Cytoplasmic Ca was measured with ratiometric microfluorometry in isolated mouse islets loaded with Fura-PE3. RESULTS: After sulfonylurea blockade of the KATP channels (50 μM-1 mM tolbutamide or 1 μM-1 mM gliclazide), increase of glucose from 3 to 20 mM resulted in suppression of elevated Ca during a 3- to 5-minute period...
April 2017: Pancreas
https://www.readbyqxmd.com/read/28196028/evaluation-of-suppressive-effects-of-tranilast-on-the-invasion-metastasis-mechanism-in-a-murine-pancreatic-cancer-cell-line
#18
Munehisa Kaneda, Hideaki Obara, Keiichi Suzuki, Osamu Takeuchi, Asako Takizawa, Masayoshi Osaku, Hajime Matsubara, Yuko Kitagawa
OBJECTIVES: Numerous studies have investigated the mechanism of the antitumor effect of tranilast, well known as an antiallergic drug. Herein, we investigated the mechanism of the antitumor effects of tranilast using murine PAN 02 cell line. METHODS: In an allograft mouse model, the number of metastatic sites in the liver was counted. Wound healing and chemoinvasion assay were performed to evaluate migration and invasive ability of PAN 02, respectively. Activities of matrix metalloproteinases (MMPs) were evaluated by gelatin zymography...
April 2017: Pancreas
https://www.readbyqxmd.com/read/28196027/mk2461-a-multitargeted-kinase-inhibitor-suppresses-the-progression-of-pancreatic-cancer-by-disrupting-the-interaction-between-pancreatic-cancer-cells-and-stellate-cells
#19
Koetsu Inoue, Hideo Ohtsuka, Masanori Tachikawa, Fuyuhiko Motoi, Masahiro Shijo, Daisuke Douchi, Shuhei Kawasaki, Kei Kawaguchi, Kunihiro Masuda, Koji Fukase, Takeshi Naitoh, Yu Katayose, Shinichi Egawa, Michiaki Unno, Tetsuya Terasaki
OBJECTIVES: Platelet-derived growth factor receptor beta (PDGFRβ) and hepatocyte growth factor receptor (MET) expressed on pancreatic stellate cells (PSCs) are suggested as important components modulating the interactions between pancreatic cancer cells (PCCs) and PSCs. The objective of this study is to clarify the effect of MK2461, a multikinase inhibitor targeting MET and PDGFRβ, on the interaction between PCCs and PSCs. METHODS: In this study, we profiled the expression of receptor tyrosine kinases (including PDGFRβ and MET) in pancreatic cancer with quantitative targeted absolute proteomics using liquid chromatography tandem mass spectrometry...
April 2017: Pancreas
https://www.readbyqxmd.com/read/28196026/caffeine-inhibits-fluid-secretion-by-interlobular-ducts-from-guinea-pig-pancreas
#20
Yuka Mochimaru, Akiko Yamamoto, Miyuki Nakakuki, Makoto Yamaguchi, Ituka Taniguchi, Hiroshi Ishiguro
OBJECTIVES: Caffeine is contained in coffee, tea, and numerous beverages and foods. We examined the direct effects of caffeine on the physiological function of pancreatic duct cells by using interlobular duct segments isolated from guinea pig pancreas. METHODS: The rate of fluid secretion was continuously measured by monitoring the luminal volume of isolated duct segments. Changes in intracellular Ca concentration ([Ca]i) were estimated by microfluorometry in ducts loaded with Fura-2...
April 2017: Pancreas
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