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Robert H Wilson, Malavika Chandra, James M Scheiman, Seung Yup Lee, Oliver E Lee, Barbara J McKenna, Diane M Simeone, Jeremy M G Taylor, Mary-Ann Mycek
OBJECTIVES: Current pancreatic cancer diagnostics cannot reliably detect early disease or distinguish it from chronic pancreatitis. We test the hypothesis that optical spectroscopy can accurately differentiate cancer from chronic pancreatitis and normal pancreas. We developed and tested clinically compatible multimodal optical spectroscopy technology to measure reflectance and endogenous fluorescence from human pancreatic tissues. METHODS: Freshly excised pancreatic tissue specimens (39 normal, 34 chronic pancreatitis, 32 adenocarcinoma) from 18 patients were optically interrogated, with site-specific histopathology representing the criterion standard...
November 17, 2016: Pancreas
Hayato Nagase, Daisuke Kudo, Akiko Suto, Eri Yoshida, Shinichiro Suto, Mika Negishi, Ikuko Kakizaki, Kenichi Hakamada
OBJECTIVES: Pancreatic ductal adenocarcinoma contains large amounts of the glycosaminoglycan hyaluronan (HA), which is involved in various physiological processes. Here, we aimed to clarify the anticancer mechanisms of 4-methylumbelliferone (MU), a well-known HA synthesis inhibitor. METHODS: MIA Paca-2 human pancreatic cancer cells were used. We evaluated cellular proliferation, migration, and invasion in the presence of MU, exogenous HA, and an anti-CD44 antibody...
November 11, 2016: Pancreas
Song Han, Ella W Englander, Guillermo A Gomez, George H Greeley
OBJECTIVES: Inflammation plays a key role in pancreatitis. Earlier studies from our laboratory showed that experimental pancreatitis activated the pancreatic apelin-APJ axis robustly in mice. Apelin signaling reduced neutrophil invasion and the activation of pancreatic nuclear factor (NF)-κB in mice with experimental pancreatitis. METHODS: The aim of this study was to assess whether apelin-induced inhibition of pancreatic NF-κB activation was linked mechanistically to apelin's inhibition of pancreatic inflammatory mediator up-regulation in mice with cerulein-induced chronic pancreatitis (CP)...
November 11, 2016: Pancreas
Laura Kuhlmann, Wiebke M Nadler, Alexander Kerner, Sabrina A Hanke, Elisa M Noll, Christian Eisen, Elisa Espinet, Vanessa Vogel, Andreas Trumpp, Martin R Sprick, Christoph P Roesli
OBJECTIVES: Pancreatic ductal adenocarcinoma (PDAC) has been subclassified into 3 molecular subtypes: classical, quasi-mesenchymal, and exocrine-like. These subtypes exhibit differences in patient survival and drug resistance to conventional therapies. The aim of the current study is to identify novel subtype-specific protein biomarkers facilitating subtype stratification of patients with PDAC and novel therapy development. METHODS: A set of 12 human patient-derived primary cell lines was used as a starting material for an advanced label-free proteomics approach leading to the identification of novel cell surface and secreted biomarkers...
November 11, 2016: Pancreas
Lin Yuan, Mengdie Tang, Lin Huang, Yi Gao, Xueliang Li
OBJECTIVES: The aim of this study was to evaluate the risk factors for hyperglycemia development after a first episode of acute pancreatitis (AP). METHODS: Three hundred and ten patients treated for AP were retrospectively evaluated. Hyperglycemia was determined by fasting blood glucose. All data were collected from the medical records room database and a follow-up telephone call. RESULTS: The incidence rate of hyperglycemia was obviously increased 5 years after the event...
November 11, 2016: Pancreas
Milena Di Leo, Gioacchino Leandro, Satish K Singh, Alberto Mariani, Margherita Bianco, Raffaella Alessia Zuppardo, Elisabetta Goni, Teresa Marzia Rogger, Francesco Di Mario, Mario Guslandi, Francesco De Cobelli, Alessandro Del Maschio, Pier Alberto Testoni, Giulia Martina Cavestro
OBJECTIVES: The aim of this study was to investigate the contribution of smoking and alcohol intake and pancreas divisum on the risk of developing chronic pancreatitis (CP). METHODS: Consecutive patients with CP who underwent secretin-enhanced magnetic resonance cholangiopancreatography were compared with consecutive patients without pancreatic disease who underwent secretin-enhanced magnetic resonance cholangiopancreatography for irritable bowel syndrome. RESULTS: We enrolled 145 consecutive CP patients and 103 irritable bowel syndrome patients from 2010 to 2014...
November 11, 2016: Pancreas
Ujjal Poddar, Surender Kumar Yachha, Vibhor Borkar, Anshu Srivastava, Sheo Kumar
OBJECTIVES: Because there is paucity of data on natural history of pediatric pancreatitis, we studied prevalence, etiology, severity, and outcome of pancreatitis. METHODS: Over 12 years consecutive children with pancreatitis were included. Pancreatitis was classified as acute (AP), acute recurrent (ARP), and chronic pancreatitis (CP) as per standard definitions. RESULTS: The study group comprised of 320 children (age, 11.4 ± 3.5 years, 201 males); AP, 160 (50%); ARP, 67 (21%); and CP, 93 (29%)...
November 11, 2016: Pancreas
Ryan D Nipp, Andrea Zanconato, Hui Zheng, Cristina R Ferrone, Keith D Lillemoe, Jennifer Y Wo, Theodore S Hong, Jeffrey W Clark, David P Ryan, Carlos Fernandez-Del Castillo
OBJECTIVES: Neoadjuvant treatments are increasingly used for patients with pancreatic ductal adenocarcinoma (PDAC), yet some experience early mortality after resection. We sought to identify predictors of early mortality after PDAC resection and determine their interaction with neoadjuvant therapy. METHODS: We performed a retrospective study of patients with PDAC resection from March 2011 to March 2014. We compared those who died within one year after surgery to those living beyond 1 year, and those who received neoadjuvant therapy to those taken directly to surgery...
November 11, 2016: Pancreas
Douglas Grunwald, Joseph D Feuerstein, Irena Maria Maier, Sunil G Sheth
OBJECTIVES: Historically, less than half of peer-reviewed abstracts are published. We set out to determine how many pancreas-related abstracts are published within 5 years of presentation at gastroenterology conferences and to determine a model that predicts successful transition from abstract to journal publication. METHODS: We collected data on study design from all pancreas-related abstracts at the 2010 Digestive Disease Week (DDW), American College of Gastroenterology, and American Pancreatic Association conferences...
November 11, 2016: Pancreas
Matthew B Rogers, Victoria Aveson, Brian Firek, Andrew Yeh, Brandon Brooks, Rachel Brower-Sinning, Jennifer Steve, Jillian F Banfield, Amer Zureikat, Melissa Hogg, Brian A Boone, Herbert J Zeh, Michael J Morowitz
OBJECTIVE: The goals of this study were to characterize bacterial communities within fecal samples, pancreatic fluid, bile, and jejunal contents from patients undergoing pancreaticoduodenectomy (PD) and to identify associations between microbiome profiles and clinical variables. METHODS: Fluid was collected from the pancreas, common bile duct, and proximal jejunum from 50 PD patients. Postoperative fecal samples were also collected. The microbial burden within samples was quantified with droplet digital polymerase chain reaction...
November 11, 2016: Pancreas
Vittoria Rufini, Frediano Inzani, Antonella Stefanelli, Paola Castaldi, Germano Perotti, Annarita Cinquino, Luca Indovina, Guido Rindi
OBJECTIVE: The aim of the study was to assess the value and potential pitfalls of Ga-DOTANOC positron emission tomography/computed tomography (PET/CT) in patients with suspected pancreatic neuroendocrine neoplasms (pNEN). METHODS: Consecutive patients referred for Ga-DOTANOC PET/CT for suspected pNEN between May 1, 2011, and October 31, 2014, were retrospectively assessed. Scan data were compared with cytological/histological final diagnosis. Pancreatic neuroendocrine neoplasm detection rate was determined on per-patient and per-lesion basis...
November 11, 2016: Pancreas
Alexey V Polonikov, Tatyana A Samgina, Petr M Nazarenko, Olga Y Bushueva, Vladimir P Ivanov
OBJECTIVES: The present study was designed to investigate whether the susceptibility to acute pancreatitis (AP) attributable to polymorphism rs10273639 at the PRSS1-PRSS2 locus is dependent on alcohol consumption and cigarette smoking. METHODS: A total of 603 unrelated Russian individuals including 304 patients with physician-diagnosed AP and 299 sex- and age-matched healthy controls have been recruited for the study. A polymorphism rs10273639 (-408C>T) of PRSS1-PRSS2 was genotyped by TaqMan-based assay...
November 11, 2016: Pancreas
Ligia Alfaro Cruz, Andrea Parniczky, Allison Mayhew, Lindsey N Hornung, Tom K Lin, Joseph J Palermo, Kimberly Jackson, Maisam Abu-El-Haija
OBJECTIVES: Exocrine pancreatic insufficiency (EPI) can have a significant impact on a child's growth and nutrition. Our aim was to evaluate the utility of direct endoscopic pancreatic function testing (ePFT) in pediatrics. METHODS: A single-center retrospective chart review was performed of children who underwent ePFT from December 2007 through February 2015. Endoscopic pancreatic function testings were performed by 1 of 2 methods: (1) intravenous cholecystokinin, followed by the collection of a single duodenal aspirate at 10 minutes, or (2) intravenous cholecystokinin or secretin, followed by the collection of 3 duodenal aspirates at a 5, 10, and 15 minutes...
November 11, 2016: Pancreas
Ingrid C A W Konings, Femme Harinck, Jan-Werner Poley, Cora M Aalfs, Anja van Rens, Nanda C Krak, Anja Wagner, C Yung Nio, Rolf H Sijmons, Hendrik M van Dullemen, Frank P Vleggaar, Margreet G E M Ausems, Paul Fockens, Jeanin E van Hooft, Marco J Bruno
OBJECTIVES: The aim of this study was to compare the prevalence of cystic pancreatic lesions and their natural behavior in 2 distinct high-risk groups for developing pancreatic ductal adenocarcinoma (PDAC): (1) carriers of a mutation that predisposes to PDAC and (2) individuals without a known gene mutation but with a family history of PDAC (familial pancreatic cancer [FPC]). METHODS: Pancreatic surveillance by annual magnetic resonance imaging and endoscopic ultrasound was performed in individuals with an estimated lifetime risk of developing PDAC of 10% or greater...
November 11, 2016: Pancreas
Janusz Gorczyca, Krzysztof A Tomaszewski, Brandon Michael Henry, Przemysław Andrzej Pękala, Artur Pasternak, Ewa Mizia, Jerzy A Walocha
OBJECTIVES: Detailed knowledge on the development of the pancreas is required to understand the variability in its blood supply. The aim of our study was to use the corrosion casting method combined with scanning electron microscopy to study the organization of the pancreatic microcirculation in human fetuses. METHODS: The study was conducted on 28 human fetuses aged 18 to 25 gestational weeks. The fetal vasculature was appropriately prepared and then perfused with a low-viscosity Mercox CL-2R resin...
November 11, 2016: Pancreas
Kara L Raphael, Saurabh Chawla, Sungjin Kim, Christopher G Keith, David R Propp, Zhengjia N Chen, Kevin E Woods, Steven A Keilin, Qiang Cai, Field F Willingham
OBJECTIVES: Tobacco exposure is an established risk factor for pancreatic cancer and chronic pancreatitis; however, its role in pancreatic insufficiency is not clear. METHODS: This controlled, cross-sectional study examined smokers and nonsmokers with no history of pancreatic disease. Histories and validated inventories of alcohol and tobacco use were obtained, and pancreatic insufficiency was assessed using the fecal elastase-1 assay. RESULTS: Of 7854 patients approached, 226 were interviewed and 200 enrolled...
November 11, 2016: Pancreas
Volker Kunzmann, Ramesh K Ramanathan, David Goldstein, Helen Liu, Stefano Ferrara, Brian Lu, Markus F Renschler, Daniel D Von Hoff
OBJECTIVES: Results from the phase 3 Metastatic Pancreatic Adenocarcinoma Clinical Trial (MPACT) led to approval of nab-paclitaxel plus gemcitabine for first-line treatment of metastatic pancreatic cancer. The current analysis evaluated the effects of nab-paclitaxel plus gemcitabine versus gemcitabine on primary pancreatic and metastatic lesions. METHODS: In this analysis of the previously described MPACT trial, changes in pancreatic and metastatic tumor burden were assessed using independently measured diameters of lesions on computed tomography or magnetic resonance imaging scans...
November 10, 2016: Pancreas
Anssi Nikkola, Janne Aittoniemi, Reetta Huttunen, Linnea Rajala, Isto Nordback, Juhani Sand, Johanna Laukkarinen
OBJECTIVES: Systemic levels of soluble urokinase-type plasminogen activator receptor (suPAR) are increased in various inflammatory and infectious diseases. We investigated the activation and prognostic value of plasma suPAR (P-suPAR) in patients experiencing their first acute alcohol pancreatitis (AAP). METHODS: From prospectively collected data, we measured P-suPAR concentrations in 104 patients with AAP during hospitalization and again after discharge. RESULTS: According to the revised Atlanta classification, pancreatitis was moderately severe in 29 (28%) and severe in 6 (6%) patients and these severities were combined for further analysis (non-mild AAP, n = 35; 34%)...
November 10, 2016: Pancreas
Tetsuya Takikawa, Atsushi Masamune, Naoki Yoshida, Shin Hamada, Takayuki Kogure, Tooru Shimosegawa
OBJECTIVES: Pancreatic stellate cells (PSCs) interact with pancreatic cancer cells in the tumor microenvironment. Cell constituents including microRNAs may be exported from cells within membranous nanovesicles termed exosomes. Exosomes might play a pivotal role in intercellular communication. This study aimed to clarify the microRNA signature of PSC-derived exosomes and their effects on pancreatic cancer cells. METHODS: Exosomes were prepared from the conditioned medium of immortalized human PSCs...
November 10, 2016: Pancreas
Aurélien Dupré, David Melodelima, Hannah Pflieger, Yao Chen, Jérémy Vincenot, Anthony Kocot, Stéphan Langonnet, Michel Rivoire
OBJECTIVE: New focal destruction technologies such as high-intensity focused ultrasound (HIFU) may improve the prognosis of pancreatic ductal adenocarcinoma. Our objectives were to demonstrate the safety and efficacy of intraoperative pancreatic HIFU ablation in a porcine model. METHODS: In a porcine model (N = 12), a single HIFU ablation was performed in either the body or tail of the pancreas, distant to superior mesenteric vessels. All animals were sacrificed on the eighth day...
November 10, 2016: Pancreas
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