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Pancreas

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https://www.readbyqxmd.com/read/29135679/characterization-of-the-human-pancreas-side-population-as-a-potential-reservoir-of-adult-stem-cells
#1
Petra Augstein, Thomas Loudovaris, Esther Bandala-Sanchez, Peter Heinke, Gaetano Naselli, Lily Lee, Wayne J Hawthorne, L Jorge Góñez, Alana M Neale, François Vaillant, Helen E Thomas, Thomas W Kay, Ilia Banakh, Leonard C Harrison
OBJECTIVES: The side population (SP) contains cells with stem cell/progenitor properties. Previously, we observed that the mouse pancreas SP expanded after pancreatic injury. We aimed to characterize the SP in human pancreas as a potential source of stem cells. METHODS: Human organ donor pancreata were fractionated into islets and exocrine tissue, enriched by tissue culture and dispersed into single cells. Cells were phenotyped by flow cytometry, and the SP was defined by efflux of fluorescent dye Hoechst 33342 visualized by ultraviolet excitation...
November 10, 2017: Pancreas
https://www.readbyqxmd.com/read/29040198/pancreatitis-in-patients-with-pancreas-divisum
#2
Abimbola Adike, Bara I El Kurdi, Sathvika Gaddam, Heidi E Kosiorek, Norio Fukami, Douglas O Faigel, Joseph M Collins, Francisco C Ramirez
No abstract text is available yet for this article.
November 2017: Pancreas
https://www.readbyqxmd.com/read/29040196/carcinoid-syndrome-complicating-a-pancreatic-neuroendocrine-tumor-a-case-report
#3
James N Gerson, Ronald M Witteles, Daniel T Chang, Ramin E Beygui, Andrei H Iagaru, Pamela L Kunz
Neuroendocrine tumors (NETs) comprise a heterogeneous group of neoplasms. These tumors can produce a wide variety of hormones that can lead to syndromes of hormone excess, such as carcinoid syndrome. We present the case of a 47-year-old man who presented with right upper quadrant abdominal pain and emesis. He was found to have metastatic pancreatic NET and was treated with systemic chemotherapy. He subsequently developed dyspnea on exertion and was found to have severe right-sided heart disease secondary to elevated levels of serum serotonin...
November 2017: Pancreas
https://www.readbyqxmd.com/read/29040195/grade-assignment-by-ki-67-proliferative-index-mitotic-count-and-phosphohistone-h3-count-in-surgically-resected-gastrointestinal-and-pancreatic-neuroendocrine-tumors
#4
Claire E Murphy, Kinsey A McCormick, Veena Shankaran, Deepti M Reddi, Paul E Swanson, Melissa P Upton, Antonios Papanicolau-Sengos, Sara Khor, Maria Westerhoff
OBJECTIVES: The aim of this study was to evaluate the concordance in grade assignment for gastroenteropancreatic neuroendocrine tumors using mitotic count (MC), Ki-67 proliferative index (KPI), and phosphohistone H3 count (PHH3C). METHODS: Resected gastroenteropancreatic neuroendocrine tumors were graded based on MC, KPI, and PHH3C. Concordance was determined using a weighted κ statistic. Median survival across each grade category was determined using Kaplan-Meier methods...
November 2017: Pancreas
https://www.readbyqxmd.com/read/29040194/fatty-pancreas-should-we-be-concerned
#5
Shounak Majumder, Nissy A Philip, Naoki Takahashi, Michael J Levy, Vijay P Singh, Suresh T Chari
The metabolic consequences of visceral fat deposition are well known, and the presence of intrapancreatic fat (IPF) has been recognized for decades. However, our knowledge about the distribution of fat in the pancreas and its clinical implications is in a nascent stage. Various terms have been proposed to describe IPF; for the purpose of this narrative review, we chose the general term fatty pancreas. Herein, we describe the radiologic, endoscopic, and histopathologic aspects of diagnosing fatty pancreas and provide an overview of the diseases associated with this condition...
November 2017: Pancreas
https://www.readbyqxmd.com/read/29040192/2017-american-pancreatic-association-presidential-address-revitalizing-pancreatitis-research
#6
(no author information available yet)
No abstract text is available yet for this article.
November 2017: Pancreas
https://www.readbyqxmd.com/read/28991878/fatty-acid-mediated-stromal-reprogramming-of-pancreatic-stellate-cells-induces-inflammation-and-fibrosis-that-fuels-pancreatic-cancer
#7
Tomoki Hata, Koichi Kawamoto, Hidetoshi Eguchi, Yoshihiro Kamada, Shinji Takamatsu, Tomohiro Maekawa, Satoshi Nagaoka, Daisaku Yamada, Yoshifumi Iwagami, Tadafumi Asaoka, Takehiro Noda, Hiroshi Wada, Kunihito Gotoh, Atsushi Masamune, Eiji Miyoshi, Masaki Mori, Yuichiro Doki
OBJECTIVES: Pancreatic ductal adenocarcinoma is one of the deadliest diseases worldwide. Fatty acids (FAs) have properties that affect both cancer cells and tumor environment. We assessed the effects of FAs on malignant characteristics in a pancreatic cancer and pancreatic stellate cell (PSC) coculture model. This study aimed to clarify the FA signature of PSC-derived inflammation and fibrosis in vitro and in a clinicopathological analysis. METHODS: The in vitro model involved coculture of the human pancreatic cancer cell lines PANC-1 and MIA PaCa-2 with human PSCs...
November 2017: Pancreas
https://www.readbyqxmd.com/read/28991877/cell-cycle-protein-expression-in-neuroendocrine-tumors-association-of-cdk4-cdk6-ccnd1-and-phosphorylated-retinoblastoma-protein-with-proliferative-index
#8
Yan Shi, Zhi Rong Qian, Sui Zhang, Wanwan Li, Yohei Masugi, Tingting Li, Jennifer A Chan, Juhong Yang, Annacarolina Da Silva, Mancang Gu, Li Liu, Tsuyoshi Hamada, Keisuke Kosumi, Trevor Dutton, Lauren K Brais, Reiko Nishihara, Charles S Fuchs, Shuji Ogino, Matthew H Kulke
OBJECTIVES: Dysregulation of the cell cycle has been observed and implicated as an etiologic factor in a range of human malignancies, but remains relatively unstudied in neuroendocrine tumors (NETs). We evaluated expression of key proteins involved in cell cycle regulation in a large cohort of NETs. METHODS: We evaluated immunohistochemical expression of CDKN1B, CDKN1A, CDKN2A, CDK2, CDK4, CDK6, cyclin D1, cyclin E1, and phosphorylated retinoblastoma protein (phospho-RB1) in a cohort of 267 patients with NETs...
November 2017: Pancreas
https://www.readbyqxmd.com/read/28984793/spink1-gene-is-significantly-associated-with-pancreatitis-a-comprehensive-meta-analysis
#9
Jie Liu, Shun-Yuan Lu, Yan-Gui Wang, Zhi-Yun Wei, Hong-Xin Zhang
OBJECTIVES: This research was applied to case-control studies of the association between pancreatitis and SPINK1 gene to assess the joint evidence for the association, the influence of individual studies, and evidence for publication bias. METHODS: MEDLINE and Embase were searched to identify longitudinal studies evaluating pancreatitis and SPINK1. Odds ratios (ORs) and 95% confidence interval (CI) were pooled using random-effect models and calculated using Carlin method...
November 2017: Pancreas
https://www.readbyqxmd.com/read/28984792/effects-of-ghrelin-mirna-on-inflammation-and-calcium-pathway-in-pancreatic-acinar-cells-of-acute-pancreatitis
#10
Xiping Tang, Guodu Tang, Zhihai Liang, Mengbin Qin, Chunyun Fang, Luyi Zhang
OBJECTIVES: The study investigated the effects of endogenous targeted inhibition of ghrelin gene on inflammation and calcium pathway in an in vitro pancreatic acinar cell model of acute pancreatitis. METHODS: Lentiviral expression vector against ghrelin gene was constructed and transfected into AR42J cells. The mRNA and protein expression of each gene were detected by reverse transcription polymerase chain reaction, Western blotting, or enzyme-linked immunosorbent assay...
November 2017: Pancreas
https://www.readbyqxmd.com/read/28984791/sex-determining-region-y-box-9-induces-chemoresistance-in-pancreatic-cancer-cells-by-induction-of-putative-cancer-stem-cell-characteristics-and-its-high-expression-predicts-poor-prognosis
#11
Taku Higashihara, Hideyuki Yoshitomi, Yasuyuki Nakata, Shingo Kagawa, Shigetsugu Takano, Hiroaki Shimizu, Atsushi Kato, Katsunori Furukawa, Masayuki Ohtsuka, Masaru Miyazaki
OBJECTIVES: Pancreatic cancer is a highly chemoresistant tumor and underlying mechanisms are not well understood. Sex determining region Y box 9 (Sox9) is a transcription factor playing important roles on maintenance of pluripotent cells during pancreatic organogenesis. The purpose of this study is to evaluate the roles of Sox9 in pancreatic cancer. METHODS: The Sox9 expression was evaluated by immunohistochemical analysis. Effects of Sox9 inhibition by siRNA or shRNA on chemosensitivity, sphere formation, stem cell markers expression, and in vivo tumor formation rate were examined using pancreatic cancer cell lines...
November 2017: Pancreas
https://www.readbyqxmd.com/read/28984790/different-clinical-characteristics-between-distal-cholangiocarcinoma-and-pancreatic-head-carcinoma-with-biliary-obstruction
#12
Yukihiro Yokoyama, Tomoki Ebata, Tsuyoshi Igami, Gen Sugawara, Takashi Mizuno, Junpei Yamaguchi, Masato Nagino
OBJECTIVES: The aim of this study was to compare the perioperative clinical characteristics between patients with distal cholangiocarcinoma (DCC) and pancreatic head carcinoma (PHC) with biliary obstruction. METHODS: This study included patients who underwent pancreatoduodenectomy and were diagnosed with DCC (n = 85) or PHC (n = 90) by final pathological examination. Perioperative clinical characteristics were compared for patients with DCC versus PHC with biliary obstruction...
November 2017: Pancreas
https://www.readbyqxmd.com/read/28984789/s100p-in-duodenal-fluid-is-a-useful-diagnostic-marker-for-pancreatic-ductal-adenocarcinoma
#13
Taketo Matsunaga, Takao Ohtsuka, Koichi Asano, Hideyo Kimura, Kenoki Ohuchida, Hidehisa Kitada, Noboru Ideno, Yasuhisa Mori, Shoji Tokunaga, Yoshinao Oda, Sushovan Guha, Massimo Raimondo, Masafumi Nakamura, Masao Tanaka
OBJECTIVES: The development of an effective screening method for pancreatic ductal adenocarcinoma (PDAC) is of paramount importance. This study assessed the diagnostic utility in pancreatic diseases of duodenal markers during upper gastrointestinal endoscopy (GIE) or endoscopic ultrasonography. METHODS: This study prospectively enrolled 299 consecutive participants, including 94 patients with PDACs, 144 patients with other pancreatic diseases, and 61 normal individuals as control subjects...
November 2017: Pancreas
https://www.readbyqxmd.com/read/28984788/concurrent-diabetic-ketoacidosis-in-hypertriglyceridemia-induced-pancreatitis-how-does-it-affect-the-clinical-course-and-severity-scores
#14
Yuchen Wang, Bashar M Attar, Keiki Hinami, Palashkumar Jaiswal, John Erikson Yap, Radhika Jaiswal, Kalpit Devani, Carlos Roberto Simons-Linares, Melchor V Demetria
OBJECTIVES: Concurrent diabetic ketoacidosis (DKA) is highly prevalent in patients with hypertriglyceridemia-induced pancreatitis (HP). Diabetic ketoacidosis could potentially complicate the diagnosis, management, and prognosis of HP. This study aimed to directly compare the clinical course of HP with and without DKA and assess the outcomes of frequently used severity-prediction scores in such population. METHODS: We retrospectively analyzed 140 patients with HP; 37 patients (26...
November 2017: Pancreas
https://www.readbyqxmd.com/read/28984787/effects-of-%C3%AF-3-fatty-acids-on-toll-like-receptor-4-and-nuclear-factor-%C3%AE%C2%BAb-p56-in-the-pancreas-of-rats-with-severe-acute-pancreatitis
#15
Bin Wang, Xiao-Bing Xu, Xin-Xin Jin, Xiao-Wei Wu, Min-Li Li, Mei-Xia Guo, Xiao-Hua Zhang
OBJECTIVES: The aims of this study were to determine the effects of ω-3 fatty acids (ω-3FAs) on the Toll-like receptor 4 (TLR4)/nuclear factor κB p56 (NF-κBp56) signaling pathway in the pancreas of rats with severe acute pancreatitis (SAP). METHODS: Sixty-four Sprague-Dawley rats were randomly divided into 4 groups: the control, SAP-saline, SAP-soybean oil, and SAP-ω-FA groups. Severe acute pancreatitis was induced by the retrograde infusion of sodium taurocholate into the pancreatic duct...
November 2017: Pancreas
https://www.readbyqxmd.com/read/28984786/clinically-significant-differences-in-ki-67-proliferation-index-between-primary-and-metastases-in-resected-pancreatic-neuroendocrine-tumors
#16
Sebastian Richards-Taylor, Charles Tilley, Eleanor Jaynes, Haixiao Hu, Thomas Armstrong, Neil W Pearce, Rachel Plant, Judith Cave
OBJECTIVE: Pancreatic neuroendocrine tumors (NETs) (pNETs) have a varied prognosis according to their grade. The European Neuroendocrine Tumor Society grading system uses assessment of the proliferation index via Ki-67 immunohistochemistry to aid prognosis. There is evidence that the proliferation index can vary significantly within a single tumor, but it is not fully understood to what extent heterogeneity occurs between the primary and metastatic sites and how this may affect the grade...
November 2017: Pancreas
https://www.readbyqxmd.com/read/28984785/intestinal-fatty-acid-binding-protein-and-citrulline-as-markers-of-gut-injury-and-prognosis-in-patients-with-acute-pancreatitis
#17
Pooja Goswami, Ujjwal Sonika, Praneeth Moka, Vishnubhatla Sreenivas, Anoop Saraya
OBJECTIVES: Severe acute pancreatitis (AP) is associated with high mortality due to systemic inflammatory response syndrome in the early phase and secondary infection in the later phase. Concomitant intestinal ischemia often results in gut injury. We studied intestinal fatty acid binding protein (IFABP) and citrulline levels as markers of gut injury to predict prognosis in AP. METHODS: Acute pancreatitis patients at admission and controls were studied. Serum IFABP was measured by enzyme-linked immunosorbent assay and plasma citrulline by high-performance liquid chromatography technique...
November 2017: Pancreas
https://www.readbyqxmd.com/read/28953187/early-detection-of-pancreatic-cancer-the-role-of-industry-in-the-development-of-biomarkers
#18
Barbara J Kenner, Vay Liang W Go, Suresh T Chari, Ann E Goldberg, Laura J Rothschild
A diagnosis of pancreatic cancer is devastating owing to its poor prognosis, with a 5-year survival rate of only 9%. Currently, most individuals are diagnosed at a late stage when treatment options are limited. Early detection of pancreatic cancer provides the greatest hope for making substantial improvements in survival. The Kenner Family Research Fund in partnership with the American Pancreatic Association has sponsored a series of fora to stimulate discussion and collaboration on early detection of pancreatic cancer...
November 2017: Pancreas
https://www.readbyqxmd.com/read/28930868/next-generation-sequencing-revealed-tp53-mutations-to-be-malignant-marker-for-intraductal-papillary-mucinous-neoplasms-that-could-be-detected-using-pancreatic-juice
#19
Shinichi Takano, Mitsuharu Fukasawa, Makoto Kadokura, Hiroko Shindo, Ei Takahashi, Sumio Hirose, Shinya Maekawa, Kunio Mochizuki, Hiromichi Kawaida, Jun Itakura, Ryohei Katoh, Hideki Fujii, Tadashi Sato, Nobuyuki Enomoto
OBJECTIVES: The aims of this study were to identify the genetic mutations associated with malignant intraductal papillary mucinous neoplasms (IPMNs) and evaluate the possibility of detecting mutations in pure pancreatic juice by next-generation sequencing. METHODS: Resected tissues were collected from 50 patients with IPMN, and pure pancreatic juice samples were collected from 19 patients who had a resection. The extracted DNA was amplified by multiplex polymerase chain reaction targeting 52 cancer-related genes, including KRAS, GNAS, RNF43, and TP53; the mutations were then detected by next-generation sequencing and then analyzed for correlations with the clinicopathological characteristics...
November 2017: Pancreas
https://www.readbyqxmd.com/read/28930867/pancreatic-neuroendocrine-tumors-computed-tomography-enhancement-but-not-histological-grade-correlates-with-tumor-aggression
#20
Motoyo Yano, Sunil Misra, Danielle H Carpenter, Amber Salter, Charles F Hildebolt
OBJECTIVES: The aims of this study were to assess computed tomography enhancement of pancreatic neuroendocrine tumors (NETs), determine correlation with histological vascularity and fibrosis, and identify a biomarker for tumor aggression. METHODS: The arterial and venous enhancement of NET was calculated on computed tomography for 56 patients. Tumor size and vascularity/fibrosis were assessed. Tumor aggression was grouped by World Health Organization and Hochwald grade and the presence of metastases...
November 2017: Pancreas
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