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Current Opinion in Cardiology

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https://www.readbyqxmd.com/read/29771736/the-role-of-diet-for-prevention-and-management-of-hypertension
#1
Cemal Ozemek, Deepika R Laddu, Ross Arena, Carl J Lavie
PURPOSE OF REVIEW: Regular consumption of a diet high in sodium, energy dense foods, fat content, refined carbohydrates, added sugar and low in fruits and vegetables contributes to an increased risk of developing hypertension (HTN) and cardiovascular disease. This review aims to provide a synopsis of evidence-based dietary approaches that have been effective in lowering blood pressure (BP) in pre-HTN and individuals with HTN. RECENT FINDINGS: Recent dietary recommendations have emphasized overall dietary patterns and its relation between food and BP...
May 15, 2018: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/29762150/physical-activity-and-fitness-for-the-prevention-of-hypertension
#2
Esmée A Bakker, Xuemei Sui, Angelique G Brellenthin, Duck-Chul Lee
PURPOSE OF REVIEW: The aim of this review is to evaluate the most recent literature about the role of physical activity, exercise, and fitness in hypertension prevention. RECENT FINDINGS: Strong evidence indicates that performing moderate-to-vigorous physical activity, particularly aerobic exercise, and improving cardiorespiratory fitness (CRF) reduce blood pressure (BP) levels and lower hypertension incidence. Although evidence is limited, performing resistance exercise or improving muscular strength appears to be associated with a lower incidence of hypertension...
May 11, 2018: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/29738343/hypertension-management-and-measurements
#3
Hector O Ventura, Carl J Lavie
No abstract text is available yet for this article.
May 5, 2018: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/29708890/antithrombotic-drugs-in-cardiovascular-medicine-a-year-in-review
#4
Homam Ibrahim, Matthew Rondina, Frederick G P Welt
PURPOSE OF REVIEW: To provide an up to date review of the most recent randomized clinical trials in the field of antithrombotic drugs for cardiovascular diseases. RECENT FINDINGS: In 2017, low-dose anti-Xa treatment added to aspirin proved to be more efficacious than either treatment alone in patients with stable atherosclerotic disease despite the increase in nonfatal bleeding events. Furthermore, anticoagulation strategy during coronary interventions was again tested in a registry-based trial and showed comparable efficacy and safety between heparin alone and bivalirudin...
April 27, 2018: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/29702500/future-pharmacological-therapy-in-hypertension
#5
Merrill H Stewart, Carl J Lavie, Hector O Ventura
PURPOSE OF REVIEW: Hypertension (HTN) is a widespread and growing disease, with medication intolerance and side-effect present among many. To address these obstacles novel pharmacotherapy is an active area of drug development. This review seeks to explore future drug therapy for HTN in the preclinical and clinical arenas. RECENT FINDINGS: The future of pharmacological therapy in HTN consists of revisiting old pathways to find new targets and exploring wholly new approaches to provide additional avenues of treatment...
April 26, 2018: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/29702499/new-antihyperglycaemic-agents-and-cardiovascular-disease-let-s-be-optimistic
#6
Kalliopi Pafili, Manfredi Rizzo, Nikolaos Papanas
PURPOSE OF REVIEW: Cardiovascular disease (CVD) substantially increases mortality in diabetes mellitus. This narrative review highlights recent research on the putative associations between dipeptyl peptidase 4 inhibitors, glucagon-like peptide-1 receptor agonists (GLP-1RAs) and sodium glucose co-transporter 2 inhibitors (SGLT-2is) and several cardiovascular risk factors. RECENT FINDINGS: New antihyperglycaemic agents favourably modulate several CVD risk factors, including fasting and postprandial plasma glucose levels, body weight, blood pressure, lipids, microalbuminuria, nonalcoholic fatty liver disease, serum uric acid, and arterial stiffness...
April 26, 2018: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/29697545/transcatheter-valvular-interventions-in-2017-some-things-old-some-things-new
#7
Hasan Rehman, Neal S Kleiman, Ankur Kalra
PURPOSE OF REVIEW: Transcatheter valvular interventions have changed the landscape of valvular therapies. We examine some studies on transcatheter valvular interventions published in the year 2017 to better understand their implications on clinical practice and future research. RECENT FINDINGS: Findings from the SURTAVI study suggest TAVR to be a reasonable option in intermediate risk patients with aortic stenosis. Recent studies indicate that valve leaflet thrombosis is associated with poor outcomes...
April 24, 2018: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/29697544/the-role-of-the-pharmacist-in-hypertension-management
#8
Katherine E Di Palo, Troy Kish
PURPOSE OF REVIEW: Hypertension remains a vital, modifiable risk factor in the prevention of cardiovascular disease. However, many patients do not achieve their therapeutic goals for numerous reasons which can include poor disease insight and nonadherence. Pharmacists can be key players in controlling hypertension, given their medication knowledge and patient counseling skills, yet they remain an underutilized resource in the management of chronic disease states. Various models exist that allow pharmacists to provide direct patient-centered care but practices differ from state to state since pharmacists are not recognized nationally as healthcare providers...
April 24, 2018: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/29697543/new-diet-trials-and-cardiovascular-risk
#9
Antonio Garcia-Rios, Jose M Ordovas, Jose Lopez-Miranda, Pablo Perez-Martinez
PURPOSE OF REVIEW: The prevalence of cardiovascular disease (CVD) is increasing to epidemic proportions and current management centred on treatment with drugs is not enough to stop this pandemic. CVD prevention is of paramount importance. In this context, diet and behavioural intervention programs are the first step and have the advantage of lesser cost and side effects than pharmacological approaches. In this review, we will examine the most recent evidence related to dietary prevention of CVD risk...
April 24, 2018: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/29697542/salt-and-hypertension-what-do-we-know
#10
James J DiNicolantonio, James H O'Keefe
PURPOSE OF REVIEW: To evaluate the evidence for population-wide sodium restriction. RECENT FINDINGS: The recommendations for population-wide sodium restriction largely rely on one surrogate marker (blood pressure). However, recent evidence suggests that when looking beyond blood pressure (e.g. heart rate, aldosterone, renin, cholesterol, triglycerides, noradrenaline and adrenaline), the net effect of sodium restriction is likely harmful. Prospective studies support the notion that those consuming the lowest amounts of salt are at the highest risk of cardiovascular events and premature death...
April 24, 2018: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/29601329/hiv-infection-and-lipids
#11
Anjly Jain, Trupti Kolvekar, Devaki R Nair
PURPOSE OF REVIEW: We comment on the role of dyslipidaemia in cardiovascular disease (CVD) in HIV-infected patients. We have discussed various risk factors, including traditional CVD risk factors, HIV-related risk factors and antiretroviral therapy (ART)-induced dyslipidaemia. RECENT FINDINGS: HIV-infected individuals are prone to lipid and lipoprotein abnormalities as a result of the infection itself and the effect of ART. The older drugs used for the treatment of HIV were associated with an increased risk of these abnormalities...
March 29, 2018: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/29601328/statin-loading-in-cardiovascular-surgery-never-too-early-to-treat
#12
Niki Katsiki, Filippos Triposkiadis, Athanasios D Giannoukas, Dimitri P Mikhailidis
PURPOSE OF REVIEW: The effects of statin loading before, during or after vascular interventions on cardiovascular and renal outcomes are discussed. Furthermore, the selection of optimal statin type and dose, according to current evidence or guidelines, is considered. The importance of treating statin intolerance and avoiding statin discontinuation is also discussed. RECENT FINDINGS: Statin loading has been shown to beneficially affect cardiovascular outcomes, total mortality and/or contrast-induced acute kidney injury, in patients undergoing vascular procedures such as percutaneous coronary intervention (PCI), coronary artery bypass grafting (CABG), carotid endarterectomy (CEA), carotid artery stenting, endovascular aneurysm repair, open abdominal aortic aneurysms (AAA) repair and lower extremities vascular interventions...
March 29, 2018: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/29561319/proprotein-convertase-subtilisin-kexin-type-9-from-genetics-to-clinical-trials
#13
Robert M Stoekenbroek, John J P Kastelein
PURPOSE OF REVIEW: This review describes the pivotal role of genetic insights and technologies in the discovery of proprotein convertase subtilisin/kexin type 9 (PCSK9) and the rapid development of PCSK9 inhibitors - a revolutionary new class of lipid-lowering agents. RECENT FINDINGS: PCSK9 was discovered as a the third gene implicated in familial hypercholesterolemia. Population genetics studies, enabled by technological advances, were instrumental in validating PCSK9 as a therapeutic target...
March 20, 2018: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/29561321/an-update-on-trials-of-novel-lipid-lowering-drugs
#14
Anthony S Wierzbicki, Timothy M Reynolds, Adie Viljoen
PURPOSE OF REVIEW: A number of novel trials have assessed the efficacy of new lipid-lowering therapies in cardiovascular disease (CVD). RECENT FINDINGS: Proprotein convertase subtilisin kexin-9 inhibitors reduce low-density lipoprotein cholesterol (LDL-C) by 50-55%. A CVD outcome trial in patients with acute coronary syndromes with evolocumab achieved a LDL-C of 0.8 mmol/l (31 mg/dl) and a 20% relative risk reduction in CVD events in 2.2 years. Cholesterol ester transfer protein inhibitors raise high-density lipoprotein cholesterol and can lower LDL-C...
March 19, 2018: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/29561320/genetic-cardiomyopathies
#15
Jane E Wilcox, Ray E Hershberger
PURPOSE OF REVIEW: To describe recent advancements in cardiovascular genetics made possible by leveraging next-generation sequencing (NGS), and to provide a framework for practical applications of genetic testing for hypertrophic (HCM), dilated (DCM), and arrhythmogenic right ventricular cardiomyopathies (ARVC). RECENT FINDINGS: The availability of NGS has made possible extensive reference databases. These, combined with recent initiatives to compile previously siloed commercial and research cardiomyopathy data sets, provide a more powerful and precise approach to cardiovascular genetic medicine...
March 19, 2018: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/29543672/heart-health-in-the-age-of-highly-active-antiretroviral-therapy-a-review-of-hiv-cardiomyopathy
#16
Mark N Belkin, Nir Uriel
PURPOSE OF REVIEW: Advancements in highly active antiretroviral therapy (HAART) for human immunodeficiency virus (HIV) has led to increased survival, approaching that of the general population. These patients are at an increased risk for heart disease, specifically HIV-associated cardiomyopathy. RECENT FINDINGS: Initially, HIV-associated cardiomyopathy was predominantly noted as systolic dysfunction, but diastolic dysfunction has become more common with increased use of HAART...
March 14, 2018: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/29543671/iron-overload-cardiomyopathy-from-diagnosis-to-management
#17
Carles Díez-López, Josep Comín-Colet, José González-Costello
PURPOSE OF REVIEW: Iron overload cardiomyopathy (IOC) is an important predictor of prognosis in a significant number of patients with hereditary hemochromatosis and hematologic diseases. Its prevalence is increasing because of improved treatment strategies, which significantly improve life expectancy. We will review diagnosis, treatment, and recent findings in the field. RECENT FINDINGS: The development of preclinical translational disease models during the last years have helped our understanding of specific disease pathophysiological pathways that might eventually change the outcomes of these patients...
March 14, 2018: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/29543670/genetic-basis-of-arrhythmogenic-cardiomyopathy
#18
Jennifer Karmouch, Alexandros Protonotarios, Petros Syrris
PURPOSE OF REVIEW: To date 16 genes have been associated with arrhythmogenic cardiomyopathy (ACM). Mutations in these genes can lead to a broad spectrum of phenotypic expression ranging from disease affecting predominantly the right or left ventricle, to biventricular subtypes. Understanding the genetic causes of ACM is important in diagnosis and management of the disorder. This review summarizes recent advances in molecular genetics and discusses the application of next-generation sequencing technology in genetic testing in ACM...
March 14, 2018: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/29543669/the-long-noncoding-rna-landscape-in-cardiovascular-disease-a-brief-update
#19
Irene Salamon, Gloria Saccani Jotti, Gianluigi Condorelli
PURPOSE OF REVIEW: In this review, we summarize new knowledge on long noncoding RNAs (lncRNAs) linked to cardiovascular disease, in particular to heart failure. RECENT FINDINGS: LncRNAs are dysregulated in specific developmental and pathological conditions and regulate critical responses to stress. LncRNAs are being recognized as molecules regulating myocardial remodeling during disease, participating for instance in the regulation of cardiomyocyte hypertrophy and function and fibroblast proliferation...
March 14, 2018: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/29624510/genetic-risk-stratification-in-cardiac-arrhythmias
#20
Carlo Napolitano, Andrea Mazzanti, Silvia G Priori
PURPOSE OF REVIEW: The current article provides a concise summary of the possibilities and limitations of genotype-based risk stratification of cardiac arrhythmias. We will outline the most important findings of the recent years in the light of their chronological and conceptual development. RECENT FINDINGS: Genotype-phenotype association studies in families with single-gene disorders as well as in the general population led to the discovery of several DNA variants significantly associated with the risk of sudden death or life-threatening arrhythmias...
May 2018: Current Opinion in Cardiology
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