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Journal of Gastroenterology and Hepatology

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https://www.readbyqxmd.com/read/28431454/da-9701-improves-colonic-transit-time-and-symptoms-in-patients-with-functional-constipation-a-prospective-study
#1
Su Young Kim, Hyun Sun Woo, Sung Han Choi, Dong Kyun Park, Kwang An Kwon, Jun-Won Chung, Yoon Jae Kim, Jung Ho Kim, Su Ji Kim, Kyoung Oh Kim
BACKGROUND AND AIM: DA-9701, a newly developed prokinetic agent formulated with Pharbitis Semen and Corydalis Tuber, has been shown to effectively treat functional dyspepsia. Recently, it has also been suspected to improve gastrointestinal motor function. The aims of this study were to assess the effect of DA-9701 on colonic transit time (CTT) and symptoms of functional constipation. METHODS: We prospectively enrolled 33 patients with functional constipation based on the Rome III criteria...
April 21, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28425144/association-between-endoscopic-findings-related-to-colonic-diverticula-and-bowel-habits-a-multicenter-study-in-japan
#2
Eiji Yamada, Hitoshi Kuriyama, Eri Uchida, Yoriko Murata, Yasuo Hata, Masataka Tagri, Yutaka Isozaki, Hirokazu Oyamada, Yukihiro Ozawa, Takafumi Ito, Akira Mizuki, Masahiko Inamori, Noriaki Manabe, Ken Haruma, Atsushi Nakajima
BACKGROUND: Few studies have shown the associations between colonic diverticula and endoscopic findings such as location, inflammation, number of diverticula, sigmoid colon rigidity and bowel habits. METHODS: We analyzed Japanese subjects who underwent total colonoscopies at six centers in Japan from November 2015 to October 2016. Bowel habits were evaluated using the Gastrointestinal Symptom Rating Scale. Location and number of diverticula, inflammation, and sigmoid colon rigidity were evaluated from endoscopy results...
April 19, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28425133/fecal-microbiota-signatures-of-adult-patients-with-different-types-of-short-bowel-syndrome
#3
Yuhua Huang, Feilong Guo, Yousheng Li, Jian Wang, Jieshou Li
BACKGROUND AND AIM: Short bowel syndrome (SBS) is a common cause of intestinal failure and can be divided into three types depending on intestinal anatomy. Gut dysbiosis has been observed in pediatric SBS patients and is associated with impaired outcome. Little is known about the changes in gut microbiota of adult SBS patients. Therefore, we aim to characterize the fecal microbiota of adult patients with different types of SBS. METHODS: Fifteen fecal samples from healthy controls and adult patients with type II or type III SBS were collected (five in each group)...
April 19, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28422327/association-between-the-ulcer-status-and-the-risk-of-delayed-bleeding-after-the-endoscopic-mucosal-resection-of-colon
#4
Gwang-Un Kim, Myeongsook Seo, Eun Mi Song, Sung Wook Hwang, Sang Hyoung Park, Dong-Hoon Yang, Jeong-Sik Byeon
BACKGROUND AND AIM: Bleeding is the most common adverse event following colonoscopic endoscopic mucosal resection (EMR). We aimed to assess the clinical outcomes of a colon EMR according to the post-EMR ulcer status, and determine the risk factors of delayed postpolypectomy bleeding (DPPB) based on the post-EMR ulcer status. METHODS: We retrospectively reviewed the medical records and endoscopic images of patients who underwent EMR of colon polyps with diameters of ≥5 mm...
April 19, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28419583/a-comparison-of-multi-factor-scoring-systems-and-single-serum-markers-for-the-early-prediction-of-the-severity-of-acute-pancreatitis
#5
Wen-Hua He, Yin Zhu, Yong Zhu, Qi Jin, Hong-Rong Xu, Zhi-Juan Xion, Min Yu, Liang Xia, Pi Liu, Nong-Hua Lu
BACKGROUND: The purpose of this study was to clarify whether the current scoring systems and single serum markers used in pancreatitis remain applicable for the early prediction of infected pancreatic necrosis (IPN), the severity and mortality of acute pancreatitis (AP) in accordance with the revised Atlanta and determinant-based classifications. METHODS: Demographic, clinical, and laboratory data from 708 consecutive patients with AP were prospectively collected between January 2011 and December 2012...
April 17, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28406534/serum-wfa-m2bp-levels-predict-liver-fibrosis-development-of-hepatocellular-carcinoma-and-overall-survival-a-meta-analysis
#6
Kiyoaki Ito, Kenta Murotani, Yukiomi Nakade, Tadahisa Inoue, Haruhisa Nakao, Yoshio Sumida, Yoshihiro Kamada, Masashi Yoneda
BACKGROUND AND AIM: A reliable, non-invasive biomarker for diagnosis of liver fibrosis in chronic liver disease patients is needed. The aim of this study was to assess by meta-analysis the efficacy of measuring serum levels of Wisteria floribunda agglutinin-positive Mac-2-binding protein (WFA(+) -M2BP), a novel and promising biomarker, for staging liver fibrosis and predicting the development of hepatocellular carcinoma and overall survival. METHODS: We performed a meta-analysis using online journal database searches...
April 12, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28387454/coeliac-disease-and-gastrointestinal-symptom-screening-in-adult-first-degree-relatives
#7
Luis Vaquero, Laura Rodríguez-Martín, Begoña Alvarez-Cuenllas, Mercedes Hernando, Cristina Iglesias-Blazquez, Cristina Menéndez-Arias, Santiago Vivas
BACKGROUND AND AIM: The first-degree relatives (FDRs) of patients with coeliac disease are the main risk group for disease development. To evaluate the screening strategy in FDRs with negative coeliac serology based on human leukocyte antigen (HLA) genotyping, followed by duodenal biopsy, and to analyze the prevalence of gastrointestinal symptoms and the influence of gluten intake. METHODS: Adult FDRs with negative coeliac serology were invited to participate (n = 205), and a total of 139 completed the study protocol...
April 7, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28387430/esophageal-mucosa-in-hiv-infection-a-deeper-look-at-this-little-spoken-organ
#8
Ana Luiza Werneck-Silva, Carla Pagliari, Roseli A Patzina, Cleusa Fumica Hirata Takakura, Maria Irma Duarte
BACKGROUND: Although the esophagus is a common site of opportunistic infection in AIDS patients little is known about the impact of HIV as well as opportunistic infection in the esophageal mucosa. Our aim is to analyze the esophageal immune profile in HIV+ patients with different immunological status with and without the opportunistic Candida infection. METHODS: Immunohistochemistry to CD4+ and CD8+ T-cells, IFN-γ, TGF-β, IL-4, IL-6, IL-13 and IL-17 was performed in esophageal samples of 40 chronically HIV+ patients under HAART (16 with Candida esophagitis, 12 virologicaly non-supressed with blood CD4 count <500, and 12 virologicaly suppressed with blood CD4 count >500; the latter two groups without esophageal candidiasis)...
April 7, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28374414/systemic-inflammatory-response-syndrome-in-acute-on-chronic-liver-failure-relevance-of-golden-window-a-prospective-study
#9
A Choudhury, M Kumar, B C Sharma, R Maiwall, V Pamecha, R Moreau, Y K Chawla, A Duseja, M Mahtab, S Rahman, S S Hamid, A S Butt, W Jafri, S S Tan, H Devarbhavi, D Amarapurkar, Q Ning, C E Eapen, Ashish Goel, D J Kim, H Ghazinian, G Shiha, G H Lee, Z Abbas, D A Payawal, A K Dokmeci, M F Yuen, L A Lesmana, Ajit Sood, A Chan, G K Lau, J I Dong Jia, Z Duan, Yu Chen, O Yokosuka, P Jain, A S Bhadoria, G Kumar, S K Sarin
BACKGROUND: SIRS is an early marker of sepsis and ongoing inflammationand has been reported in large proportion of ACLF patients. Whether sepsis is the cause or the result of liver failure is unclear and is vital to know. To address this, we investigated the course and outcome of ACLF patients without SIRS/sepsis. METHODS: Consecutive ACLF patients were monitored for the development of SIRS/sepsis and associated complications and followed till 90 days, liver transplant or death...
April 3, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28370350/daclatasvir-asunaprevir-beclabuvir-dcv-trio-all-oral-fixed-dose-combination-for-patients-with-chronic-hcv-genotype-1
#10
Jia-Horng Kao, Ming-Lung Yu, Cheng-Yuan Peng, Jeong Heo, Chi-Jen Chu, Ting-Tsung Chang, Youn-Jae Lee, Tsung-Hui Hu, Ki Tae Yoon, Seung Woon Paik, Young Suk Lim, Sang Hoon Ahn, Vasily Isakov, Fiona McPhee, Wenhua Hu, E Scott Swenson, Philip D Yin, Michelle Treitel
BACKGROUND AND AIM: This multinational (Taiwan, South Korea, Russia) phase 3 study evaluated the all-oral, ribavirin-free, fixed-dose combination (DCV-TRIO) of daclatasvir (NS5A inhibitor) 30 mg, asunaprevir (NS3 inhibitor) 200 mg, and beclabuvir (NS5B inhibitor) 75 mg, in patients with chronic HCV genotype-1 infection, with or without compensated cirrhosis. METHODS: UNITY-4 (NCT02170727) was an open-label, two-cohort study in which 169 treatment-naive (N = 138) or treatment-experienced (N = 31) patients received twice-daily DCV-TRIO for 12 weeks with 24 weeks of post-treatment follow-up...
March 31, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28370348/microvesicles-shuttled-mir-200b-attenuate-experimental-colitis-associated-intestinal-fibrosis-by-inhibiting-the-development-of-emt
#11
Jia Yang, Cheng-Zhi Zhou, Rui Zhu, Heng Fan, Xing-Xing Liu, Xue-Yun Duan, Qing Tang, Zhe-Xing Shou, Dong-Mei Zuo
BACKGROUND: Epithelial-mesenchymal transition (EMT), characterized by the decrease of E-Cad and increase of vimentin and α-SMA, was demonstrated to participate in inflammatory bowel disease (IBD) related fibrosis. MiR-200b plays an anti-fibrosis role in inhibiting EMT by targeting ZEB1 and ZEB2. But the stability of exogenous miR-200b in blood limits its application. Microvesicles (MVs), which can transfer miRNAs among cells and prevent them from degradation, may provide an excellent transport system for the delivery of miR-200b in the treatment of fibrosis...
March 31, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28370235/the-risks-of-colorectal-advanced-neoplasia-in-young-adults-versus-those-of-screening-colonoscopy-in-patients-aged-50-to-54%C3%A2-years
#12
Kyeong Ok Kim, Hyo-Joon Yang, Jae Myung Cha, Jeong Eun Shin, Hyun Gun Kim, Young-Seok Cho, Sun-Jin Boo, Jun Lee, Yunho Jung, Hyun Jung Lee, Kyu Chan Huh, Young-Eun Joo, Jongha Park, Chang Mo Moon
BACKGROUND AND AIM: The role of screening or diagnostic colonoscopy to detect advanced neoplasia in young cohorts of age < 50 is unclear. This study compared the risk of colorectal neoplasia in a young age cohort against that in 50-54 s screening cohort. METHODS: We conducted a multi-center retrospective study at 14 university hospitals to compare the detection rates of neoplasia and advanced neoplasia in screening or diagnostic colonoscopy in the young cohort of < 50s against those in screening colonoscopy in the 50-54 s cohort...
March 31, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28370253/association-between-disease-activity-and-quality-of-life-in-ulcerative-colitis-results-from-the-cronica-uc-study
#13
Julián Panés, Eugeni Domènech, Marian Aguas Peris, Pilar Nos, Sabino Riestra, Berta Juliá, Luis Cea-Calvo, Cristina Romero, Ignacio Marín-Jiménez
BACKGROUND AND AIM: In ulcerative colitis (UC), main goals of treatment are to control disease activity and normalize health-related quality of life (HRQoL). In this study, we explored the relationship between disease activity (measured using the Simple Clinical Colitis Activity Index [SCCAI]) and patient HRQoL (measured using the EuroQoL [EQ]-5D-5 L). METHODS: A total of 199 patients with UC were followed for 6 months. At Months 3 and 6, patients completed an online SCCAI...
March 29, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28332731/undiagnosed-pancreatic-exocrine-insufficiency-and-chronic-pancreatitis-in-functional-gi-disorder-patients-with-diarrhea-or-abdominal-pain
#14
N J Talley, G Holtmann, N Q Nguyen, P R Gibson, P Bampton, M Veysey, J Wong, S Philcox, N Koloski, L Bunby, M Jones
BACKGROUND & AIMS: A previous UK study showed that 6.1% of patients with diarrhea-predominant IBS (IBS-D) had evidence of severe pancreatic exocrine insufficiency (PEI), but these findings need replication. We aimed to identify the prevalence of PEl based on faecal elastase stool testing in consecutive outpatients presenting with chronic unexplained abdominal pain and/or diarrhea and/or IBS-D. METHODS: Patients aged over 40 years presenting to hospital outpatient clinics from 6 sites within Australia with unexplained abdominal pain and/or diarrhea for at least 3 months and/or IBS-D were studied...
March 23, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28321907/systematical-analyses-of-variants-in%C3%A2-dnase-i-hypersensitive-sites-identified-two-novel-hepatocellular-carcinoma-susceptibility-loci-among-chinese-population
#15
Tao Jiang, Fangzhi Du, Na Qin, Qun Lu, Juncheng Dai, Hongbing Shen, Zhibin Hu
BACKGROUND AND AIM: Although several variants located at coding and non-coding regions were evaluated by previous studies, the evidence for associations between variants located in DNase I-hypersensitive sites (DHSs) and hepatocellular carcinoma (HCC) risk was still limited. Recent advances using ENCODE data indicated that genetic variants in DHSs played an important role in carcinogenesis. Therefore, systematically investigate the associations between regulatory variants in DHSs and HCC risk should be put on the agenda...
March 20, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28303605/performance-of-scoring-systems-to-predict-mortality-of-patients-with-acute-on-chronic-liver-failure-a-systematic-review-and-meta-analysis
#16
Yi-Xiang Zheng, Xiao Zhong, Ya-Jun Li, Xue-Gong Fan
BACKGROUND: Acute-on-chronic liver failure (ACLF) has characteristic feature of multisystem organ failure, rapid progression and low early transplant-free survival. AIM: We performed a meta-analysis to determine the accuracy of five scoring systems in predicting mortality of ACLF patients. METHODS: A systematic database search was performed and retrieved articles were graded according to methodological quality. Collated data was meta-analyzed by hierarchical summarized receiver operating characteristic (HSROC) model and bivariate model to evaluate the diagnostic accuracy of scoring systems RESULT: Of 4223 studies identified, 26 studies involving 4732 ACLF patients were included...
March 16, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28299830/repeated-water-avoidance-stress-induces-visceral-hypersensitivity-role-of-il-1-il-6-and-peripheral-corticotropin-releasing-factor
#17
Tsukasa Nozu, Saori Miyagishi, Rintaro Nozu, Kaoru Takakusaki, Toshikatsu Okumura
BACKGROUND AND AIM: Repeated water avoidance stress (WAS) induces visceral hypersensitivity. Additionally, it is also known to activate corticotropin-releasing factor (CRF), mast cells and pro-inflammatory cytokines systems, but their precise roles on visceral sensation have not been determined definitely. The aim of the study was to explore this issue. METHODS: Abdominal muscle contractions induced by colonic balloon distention, i.e. visceromotor response (VMR) was detected electrophysiologically in conscious rats...
March 15, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28299819/arsenic-trioxide-combined-with-transarterial-chemoembolization-for-primary-liver-cancer-a-meta-analysis
#18
Xiu-He Lv, Chun-Hui Wang, Yan Xie
BACKGROUND: The benefit of combination therapy of arsenic trioxide (As2 O3 ) and transarterial chemoembolization (TACE) is debated. This meta-analysis was conducted to determine whether As2 O3 & TACE therapy achieves better therapeutic effects compared with TACE alone for primary liver cancer. METHODS: A systematic search of both English and Chinese databases was conducted for randomised controlled trials (RCTs). The main outcomes were therapeutic responses, survival rates, improvement in quality of life, and adverse events...
March 15, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28299813/improvement-of-liver-stiffness-in-patients-with-hepatitis-c-virus-infection-who-received-direct-acting-antiviral-therapy-and-achieved-sustained-virological-response
#19
Toshifumi Tada, Takashi Kumada, Hidenori Toyoda, Kazuyuki Mizuno, Yasuhiro Sone, Saki Kataoka, Shinichi Hashinokuchi
BACKGROUND AND AIM: There is insufficient research on whether direct-acting antiviral (DAA) therapy can improve liver fibrosis in patients with chronic hepatitis C virus (HCV). We evaluated sequential changes in liver stiffness using shear wave elastography (SWE) in patients with HCV who received DAA therapy. METHODS: A total of 210 patients with HCV who received daclatasvir and asunaprevir therapy and achieved sustained virological response (SVR) were analyzed...
March 15, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28295549/uric-acid-ameliorates-indomethacin-induced-enteropathy-in-mice-through-its-antioxidant-activity
#20
Yuichi Yasutake, Kengo Tomita, Masaaki Higashiyama, Hirotaka Furuhashi, Kazuhiko Shirakabe, Takeshi Takajo, Koji Maruta, Hirokazu Sato, Kazuyuki Narimatsu, Kenichi Yoshikawa, Yoshikiyo Okada, Chie Kurihara, Chikako Watanabe, Shunsuke Komoto, Shigeaki Nagao, Hirotaka Matsuo, Soichiro Miura, Ryota Hokari
BACKGROUND AND AIM: Uric acid is excreted from blood into the intestinal lumen, yet the roles of uric acid in intestinal diseases remain to be elucidated. In this study, we aimed to determine whether uric acid could reduce endpoints associated with nonsteroidal anti-inflammatory drug (NSAID)-induced enteropathy. METHODS: A mouse model of NSAID-induced enteropathy was generated by administering indomethacin intraperitoneally to 8-week-old male C57BL/6 mice, and then vehicle or uric acid was administered orally...
March 14, 2017: Journal of Gastroenterology and Hepatology
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