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Journal of Gastroenterology and Hepatology

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https://www.readbyqxmd.com/read/30022516/gastrointestinal-ghost-gland-in-probe-based-confocal-laser-endomicroscopy-for-diagnosing-ischemic-colitis-a-novel-approach
#1
M Zheng, M Zhang, C Li, X Wang, N Zhong, X Zuo, Y Li
No abstract text is available yet for this article.
July 19, 2018: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/30011083/cost-effectiveness-of-a-tailored-helicobacter-pylori-eradication-strategy-based-on-the-presence-of-a-23s-ribosomal-rna-point-mutation-that-causes-clarithromycin-resistance-in-korean-patients
#2
Jun-Hyung Cho, Seong Ran Jeon, Hyun Gun Kim, So-Young Jin, Suyeon Park
BACKGROUND AND AIMS: The Helicobacter pylori eradication rate using conventional triple therapy has decreased due to clarithromycin (CAM) resistance in H. pylori. Recently, dual priming oligonucleotide (DPO)-based multiplex polymerase chain reaction (PCR) can be used to detect H. pylori and point mutations in the 23S ribosomal RNA gene causing CAM resistance. This study aimed to evaluate the success rate and cost-effectiveness of tailored H. pylori eradication using DPO-PCR. METHODS: The H...
July 16, 2018: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29996177/proposed-after-direct-acting-antivirals-recommendation-for-surveillance-adres-score-for-scheduled-ultrasonography-surveillance-for-hepatocellular-carcinoma-multicenter-analysis
#3
Atsushi Hiraoka, Takashi Kumada, Chikara Ogawa, Kazuya Kariyama, Masahiro Morita, Kazuhiro Nouso, Hidenori Toyoda, Toshifumi Tada, Marie Ochi, Taisei Murakami, Hirofumi Izumoto, Hidetaro Ueki, Shogo Kitahata, Toshihiko Aibiki, Tomonari Okudaira, Hiroka Yamago, Ryuichiro Iwasaki, Hideomi Tomida, Yuji Miyamoto, Kenichiro Mori, Hideki Miyata, Eiji Tsubouchi, Masato Kishida, Tomoyuki Ninomiya, Kojiro Michitaka
BACKGROUND/AIM: To develop a scoring method using with common clinical data for predicting hepatocellular carcinoma (HCC) development after SVR 24 weeks (SVR24) after treatment with direct acting antivirals (DAAs), we retrospectively evaluated clinical features of patients who obtained SVR24. METHODS: From October 2014 to December 2017, 1069 HCV patients without a past history of HCC, who obtained SVR24 by DAAs at 2 different areas, were enrolled [the training (n=484, ChuShikoku-group) and validation (n=585, Chubu-group) sets]...
July 11, 2018: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29995979/gastrointestinal-disease-burden-and-mortality-a-public-hospital-based-study-from-2005-to-2014
#4
Jacky Shui Ho Chan, Amelia Chien Wei Chao, Vincent Chi Ho Cheung, Sophia Sau Kuen Wong, Whitney Tang, Justin Che Yuen Wu, Henry Lik Yuen Chan, Francis Ka Leung Chan, Joseph Jao Yiu Sung, Siew Chien Ng
BACKGROUND AND AIM: Gastrointestinal (GI) diseases account for substantial morbidity, mortality and health care utilization. This public hospital based study assessed the incidence and time trend of hospitalization and mortality of major GI diseases over one decade. METHODS: We conducted an observational study using population-wide database managed by the Hong Kong Hospital Authority with a principal diagnosis of GI diseases defined by ICD-9-CM coding. We measured age-standardized incidence of hospitalization, emergency admissions, multiple admissions and in-hospital mortality from 2005 to 2014 using Poisson regression...
July 11, 2018: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29992650/gastrointestinal-afatinib-induced-acute-esophageal-necrosis
#5
Y Matsumoto, S Kuroki, H Yamada
No abstract text is available yet for this article.
July 11, 2018: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29992621/biliary-transporter-gene-mutations-in-severe-intrahepatic-cholestasis-of-pregnancy-diagnostic-and-management-implications
#6
Sze Pheh Yeap, Hugh Harley, Richard Thompson, Kate Diana Williamson, John Bate, Farah Sethna, Geoffrey Farrell, William Bill Hague
BACKGROUND/AIMS: Clinical syndromes associated with biallelic mutations of bile acid (BA) transporters usually present in childhood. Subtle mutations may underlie intrahepatic cholestasis of pregnancy (ICP) and oral contraceptive steroid(OCS)-induced cholestasis. In 5 women with identified genetic mutations of such transporters, with 8 observed pregnancies complicated by ICP, we examined relationships between transporter mutations, clinical phenotypes and treatment outcomes. METHODS: Gene mutation analysis for BA transporter deficiencies was performed using Next Generation/Sanger sequencing, with analysis for gene deletions/duplications...
July 10, 2018: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29989251/gastrointestinal-a-case-of-hypereosinophilic-syndrome-with-esophageal-involvement
#7
K Takahashi, H Sato, K Tominaga, J Kohisa, S Ikarashi, K Hayashi, K Miuzno, S Hashimoto, J Yokoyama, S Terai
No abstract text is available yet for this article.
July 10, 2018: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29971822/the-complex-interplay-between-gastrointestinal-and-psychiatric-symptoms-in-ibs-a-longitudinal-assessment
#8
Cristina Stasi, Anna Caserta, Cristiana Nisita, Sonia Cortopassi, Bernardo Fani, Stefano Salvadori, Pancetti Andrea, Lorenzo Bertani, Dario Gambaccini, Nicola de Bortoli, Liliana Dell'Osso, Corrado Blandizzi, Santino Marchi, Massimo Bellini
AIMS: To better define the relationship between IBS and psychiatric disorders and to examine the efficacy of paroxetine in the treatment of IBS patients. METHODS: 150 subjects with diagnosis of IBS (Roma III criteria) and relative sub-classification (constipated, diarrhea and mixed) were assessed for psychopathological features and gastrointestinal symptoms using IBS Symptom Severity Score and were consecutively enrolled. Fifty patients assumed paroxetine for 16 weeks and were longitudinally evaluated...
July 3, 2018: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29969515/capability-of-four-sigmoidoscopy-based-screening-strategies-to-predict-proximal-neoplasia-in-an-asymptomatic-chinese-population
#9
Ping Chen, Jason Liwen Huang, Xiaoqin Yuan, Junjie Huang, Harry Haoxiang Wang, Gary Tse, Martin C S Wong, Yunlin Wu
BACKGROUND AND AIM: A proper colonoscopy referral criterion is essential for flexible sigmoidoscopy (FS) based colorectal cancer (CRC) screening. We aimed to compare the predictive capability of four existing criteria to detect proximal neoplasia (PN) and advanced proximal neoplasia (APN) in a Chinese population. METHODS: Asymptomatic Chinese participants aged 50-75 years, who received screening colonoscopy, were consecutively recruited. The four criteria, included: (1) UK FS; (2) Italian Screening for COlon REctum; (3) NORwegian Colorectal Cancer Prevention trial; (4) US clinical index...
July 3, 2018: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29968937/fecal-immunochemical-test-fit-in-colorectal-cancer-screening-colonoscopy-findings-by-different-cut-off-levels
#10
Hanna Ribbing Wilén, Johannes Blom, Jonas Höijer, Rolf Hultcrantz
BACKGROUND AND AIM: Fecal immunochemical test (FIT) is used in colorectal cancer (CRC) screening, but number of tests and cut-off level differ by program. The aim was to evaluate CRC-screening with two FIT samples in average-risk 60-year-old men and women, and to investigate Hemoglobin (Hb) level in correlation to adenoma characteristics. METHODS: We analyzed a cohort from SCREESCO (Screening of Swedish Colons) trial where participants with at least one of two FIT samples ≥10μgHb/g are offered colonoscopy...
July 3, 2018: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29968933/modified-fib-4-index-stratifies-hepatocellular-carcinoma-risk-in-chronic-hepatitis-b-patients-on-entecavir-therapy
#11
Hung-Wei Wang, Hsueh-Chou Lai, Tsung-Hui Hu, Wen-Pang Su, Sheng-Nan Lu, Chia-Hsin Lin, Chao-Hung Hung, Po-Heng Chuang, Jing-Houng Wang, Mei-Hsuan Lee, Chien-Hung Chen, Cheng-Yuan Peng
BACKGROUND & AIMS: Noninvasive fibrosis indices can predict the risk of hepatocellular carcinoma (HCC) in patients with chronic hepatitis B (CHB). Modified FIB-4 (mFIB-4) is a promising noninvasive index for predicting liver fibrosis. To investigate the predictive accuracy of several extant noninvasive fibrosis indices, including mFIB-4, for HCC incidence in CHB patients receiving long-term entecavir therapy. METHODS: We enrolled 1325 nucleos (t)ide-analogue-naïve CHB patients (noncirrhotic 844; cirrhotic 481) treated with entecavir...
July 3, 2018: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29968385/efficacy-and-safety-of-fixed-dose-combination-of-drotaverine-hydrochloride-80-mg-and-paracetamol-500-mg-in-amelioration-of-abdominal-pain-in-acute-infectious-gastroenteritis-a-randomized-controlled-trial
#12
Shiva Narang, Jitender Koli
OBJECTIVES: This randomized control trial was undertaken to assess efficacy and safety of fixed dose combination of drotaverine hydrochloride (80mg) and paracetamol (PCM) (500mg). This was done by comparison of mean pain intensity difference (mPID), total pain relief at 2 hours (TOTPAR2), onset of pain relief, decrease in number of pain episodes, global improvement and adverse effects. METHODS: A randomized double blind controlled trial for adults between 18-59 years of either gender with acute infectious diarrhea (≥3 unformed, watery or soft, stools with symptoms at-least within last 24 hours preceding randomization with duration of illness not more than 72 hours) with moderate to severe abdominal pain...
July 3, 2018: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29968320/high-mobility-group-box-1-protein-modulated-proliferation-and-radioresistance-in-esophageal-squamous-cell-carcinoma
#13
Xiaoke Di, Guofeng He, Hui Chen, Caiqiang Zhu, Qin Qin, Jingjing Yan, Xiaowen Zhang, Xinchen Sun
BACKGROUND AND AIM: The high-mobility group box 1 (HMGB1) protein plays an important role in a lot of biological behaviors, including DNA damage repair, gene transcription, cell replication and cell death and its expression is higher in many solid tumors tissues than in their adjacent normal tissues, and it is always involved in tumor proliferation, metastasis, therapeutic tolerance, and poor prognosis. However, HMGB1 in proliferation and radioresistance of esophageal squamous cell carcinoma (ESCC) remains poorly understood...
July 3, 2018: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29972865/celiac-disease-gene-expression-data-can-be-used-to-classify-biopsies-along-the-marsh-score-severity-scale
#14
Richard P G Charlesworth, Linda L Agnew, David R Scott, Nicholas M Andronicos
BACKGROUND/AIM: The diagnosis of celiac disease autoimmune pathology relies on the subjective histological assignment of biopsies into Marsh score categories. It is hypothesized that Marsh score categories have unique gene expression signatures. The aims were first, to develop a CD quantitative RT-PCR array; second define gene expression signatures associated with Marsh score categories and third, develop equations that classify biopsies into Marsh score categories and to monitor the efficacy of patient treatment...
July 2, 2018: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29968297/gastrointestinal-olmesartan-induced-enteropathy
#15
M A Shahzad, D Harding, A Ruszkiewicz, E Tran, G England, H Philpott
No abstract text is available yet for this article.
July 2, 2018: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29966173/metformin-inhibits-visceral-allodynia-and-increased-gut-permeability-induced-by-stress-in-rats
#16
Tsukasa Nozu, Saori Miyagishi, Shima Kumei, Rintaro Nozu, Kaoru Takakusaki, Toshikatsu Okumura
BACKGROUND AND AIM: Metformin has been shown to have anti-cytokine property. Lipopolysaccharide (LPS)- or repeated water avoidance stress (WAS)-induced visceral allodynia and increased gut permeability were proinflammatory cytokine-dependent responses, which were considered to be animal models of irritable bowel syndrome (IBS). We hypothesized that metformin improves symptoms in the patients with IBS by attenuating these visceral changes and tested the hypothesis in rats. METHODS: The threshold of the visceromotor response (VMR) induced by colonic balloon distention was measured...
July 2, 2018: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29966170/the-effect-of-extracorporeal-low-energy-shockwave-on-diabetic-gastroparesis-in-a-rat-model
#17
Keng-Liang Wu, Yi-Chun Chiu, Chih-Chien Yao, Cheng-En Tsai, Ming-Luen Hu, Chung-Mou Kuo, Wei-Chen Tai, Seng-Kee Chuah, Chang-Chun Hsiao
BACKGROUND AND AIM: Delayed gastric emptying occurs in more than 50% of chronic diabetic patients and this is associated with significant impairments in quality of life. Traditional therapy for delayed gastric emptying has focused on supportive treatment and there is no significant effective therapy. The effect of low-energy shockwave on gastric motility is never studied. We investigated low-energy shockwave on gastric motility in a diabetic rat model. METHODS: Twenty-eight male Wistar rats were studied and separated in three groups in randomized order as: control, diabetic rats received shockwave, and diabetic rats received the sham procedure...
July 2, 2018: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29961947/gastrointestinal-huge-submucosal-hematoma-of-the-stomach-arising-in-a-patient-with-vascular-type-ehlers-danlos-syndrome
#18
M Kato, S Shinzaki, Y Tsujii, Y Hayashi, H Iijima, Y Maegawa, T Yakushijin, T Takehara
No abstract text is available yet for this article.
July 1, 2018: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29952142/gastrointestinal-wrong-connection-an-infected-mediastinal-pseudocyst-complicating-disconnected-duct-syndrome
#19
V Zimmer
No abstract text is available yet for this article.
June 27, 2018: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29952025/gastrointestinal-multiple-venous-malformations-and-polyps-of-the-small-intestine-in-cowden-syndrome
#20
A Harada, J Umeno, M Esaki
No abstract text is available yet for this article.
June 27, 2018: Journal of Gastroenterology and Hepatology
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