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Journal of Gastroenterology and Hepatology

T Kumei, Y Toya, T Shiohata, F Kakuta, S Yanai, K Kawasaki, S Nakamura, T Matsumoto
No abstract text is available yet for this article.
January 14, 2019: Journal of Gastroenterology and Hepatology
Michiko Wada, Toshihiro Nishizawa, Motohiko Kato, Yuichiro Hirai, Satoshi Kinoshita, Hideki Mori, Yoshihiro Nakazato, Ai Fujimoto, Masahiro Kikuchi, Toshio Uraoka, Takanori Kanai
BACKGROUND AND AIM: A significant percentage of patients with colonic diverticular bleeding (CDB) experience bleeding that is severe enough to necessitate prolonged hospitalization. Prolonged hospitalization causes deterioration in patients' quality of life, as well as difficulties with cost-effective utilization of medical resources and is a financial burden to the society. Therefore, we investigated the factors associated with the length of hospitalization for the optimal management of patients hospitalized with CDB...
January 12, 2019: Journal of Gastroenterology and Hepatology
Hyun Woo Lee, Jong Ho Moon, Yun Nah Lee, Tae Hoon Lee, Moon Han Choi, Sang-Woo Cha, Young Deok Cho, Sang-Heum Park
BACKGROUND: Fully covered self-expandable metal stents (FCSEMS) may be better than plastic stents (PS) for preoperative biliary drainage (PBD) to relieve cholangitis or jaundice for resectable malignant biliary obstruction (MBO). However, modification of current FCSEMS designed originally for nonresectable MBO is needed to be a proper stent for PBD. The aim of this study was to evaluate the possible superiority of non-flared modified FCSEMS (M-FCSEMS) with 12 mm diameter and waist of central portion over PS in patients with resectable MBO...
January 7, 2019: Journal of Gastroenterology and Hepatology
Salman Hussain, Ali Nasir Siddiqui, Harveen Baxi, Anwar Habib, Md Sarfaraj Hussain, Abul Kalam Najmi
AIM: Atrial fibrillation (AF) is one of the most common co-morbid conditions in hemodialysis patients and warfarin is widely prescribed anticoagulant to prevent thromboembolic complications in such patients. In the last decade, several epidemiological studies pointed out the risk of bleeding with the use of warfarin. So, this meta-analysis is aimed to assess the bleeding risk associated with the use of warfarin. METHODS: This meta-analysis was conducted in accordance with the PRISMA guidelines...
January 6, 2019: Journal of Gastroenterology and Hepatology
Imran M Paruk, Vasudevan G Naidoo, Fraser J Pirie, Sureka Maharaj, Ntombifikile M Nkwanyana, Hilary L Dinnematin, Yasmeen Ganie, Pratistadevi K Ramdial, Ayesha A Motala
AIMS: To assess the prevalence and characteristics of CD in all patients with Type 1 diabetes mellitus (T1DM) attending a tertiary adult diabetes clinic in Durban, South Africa. METHODS: This was a cross-sectional observational study which screened 202 patients; of these 56.4% were African (black), 31.7% Asian Indian, 4.5% White and 7.4% mixed race. Demographic data, symptoms and anthropometry were documented. Blood tests included anti-tissue transglutaminase antibody (tTG), anti-endomysial antibody (EMA), anti-gliadin antibody (AGA)...
January 1, 2019: Journal of Gastroenterology and Hepatology
Hideki Fujii, Kento Imajo, Masato Yoneda, Takashi Nakahara, Hideyuki Hyogo, Hirokazu Takahashi, Tasuku Hara, Saiyu Tanaka, Yoshio Sumida, Yuichiro Eguchi, Kazuaki Chayama, Atsushi Nakajima, Naoki Nishimoto, Norifumi Kawada
BACKGROUND AND AIM: Although nonalcoholic fatty liver disease (NAFLD) is common in the general population, identifying patients with advanced fibrosis remains a challenge. We investigated whether the homeostasis model assessment parameter of insulin resistance (HOMA-IR), an index of insulin resistance (IR) and one of the most important metabolic factors, is an independent predictive factor for advanced fibrosis in nondiabetic patients with NAFLD. METHODS: This was a retrospective, cross-sectional multicenter study...
January 1, 2019: Journal of Gastroenterology and Hepatology
Kenichi Nishie, Shuhei Yamamoto, Takayoshi Yamaga, Naoto Horigome, Masayuki Hanaoka
BACKGROUND AND AIM: Opioid-induced constipation (OIC) is a frequent adverse event (AE) that impairs patients' quality of life (QOL). Peripherally acting mu-opioid receptor antagonists (PAMORAs) have been recognized as a treatment option for OIC but the effect consistent across the studies has not been evaluated. METHODS: We conducted a quantitative meta-analysis to explore the efficacy of PAMORA for OIC (registered with PROSPERO: CRD42018085298). We systematically searched randomized controlled trials (RCTs) in Medline, Embase, and Central databases...
December 29, 2018: Journal of Gastroenterology and Hepatology
Chuan-Quan Lin, Li-Hui Wang, Long Yang, Xiang-Hong Qiu, Dong-Xu Wang, Xue-Dan Liang, Long-Hui Chen, Hai-Mei Xie, Shuang-Shuang Wang, Ru-Liu Li
BACKGROUND AND AIMS: Salivary characteristics are altered in gastrointestinal diseases and related to oral taste disorder. However, specific salivary biochemical characteristics and their relationships with oral taste disturbances in chronic non-atrophy gastritis (CNAG) remain uncertain. METHODS: 70 patients with CNAG and 70 subjects in healthy control group (HCG) were enrolled in our study. The levels of salivary flow rate (SFR), pH, salivary α-amylase (sAA) activity, total protein density (TPD), chloride concentration and calcium concentration were determined before and after citric acid stimulation, and compared between CNAG with and without oral taste disturbances...
December 29, 2018: Journal of Gastroenterology and Hepatology
Y M Park, C K Lee, H J Kim
No abstract text is available yet for this article.
December 27, 2018: Journal of Gastroenterology and Hepatology
Maki Tobari, Estuko Hashimoto, Makiko Taniai, Yuuichi Ikarashi, Kazuhisa Kodama, Tomomi Kogiso, Katsutoshi Tokushige, Nishino Takayoshi, Naotake Hashimoto
AIMS: To elucidate features of nonobese nonalcoholic fatty liver disease (NAFLD), we assessed Japanese patients with NAFLD stratified by body mass index (BMI) and by sex. METHODS: Biopsy-proven 762 NAFLD patients (404 men) were classified into three groups by the Japanese criteria: nonobese group (BMI <25 kg/m2 ), obese group (25 to 30), and severely obese group (≥30). Clinicopathological features and single nucleotide polymorphism of patatin-like phospholipase 3(PNPLA3) rs738409 were investigated, and body composition analysis was performed by bioelectrical impedance analysis and computed tomography...
December 27, 2018: Journal of Gastroenterology and Hepatology
Ying Cai, Wen Liu, Yixuan Lin, Shaobao Zhang, Baorong Zou, Dan Xiao, Lei Lin, Yuping Zhong, Haihui Zheng, Qiongfeng Liao, Zhiyong Xie
BACKGROUND AND AIM: Inflammatory bowel disease (IBD) results from a dysregulated immune response to intestinal microbial flora in individuals with genetic predisposition(s). This study aimed to determine the effects of compound polysaccharides (CP) containing yam polysaccharide and inulin on the rat model of colitis induced by 2,4,6-trinitrobenzenesulfonic acid (TNBS) and to explain the mechanism in terms of gut microbiota composition and function. METHODS: Male SD rats were divided into three groups: the control group, the model group and the CP group...
December 27, 2018: Journal of Gastroenterology and Hepatology
Nathalie Van den Berghe, Bram Verstockt, Sophie Tops, Marc Ferrante, Séverine Vermeire, Ann Gils
BACKGROUND AND AIM: The pivotal GEMINI trials reported low immunogenicity of vedolizumab. However, anti-vedolizumab antibodies (AVA) are frequently underestimated since most assays are not drug-tolerant and unable to detect anti-drug antibodies while there is drug in the circulation. This study aimed to explore which anti-drug antibody assay is best suited to detect AVA and investigated immunogenicity of vedolizumab in inflammatory bowel disease (IBD) patients discontinuing vedolizumab therapy...
December 27, 2018: Journal of Gastroenterology and Hepatology
Jing Zhou, Rongce Zhao, Tinghong Ye, Shuping Yang, Yali Li, Fangfang Yang, Gang Wang, Yongmei Xie, Qiu Li
BACKGROUND AND AIM: Colorectal cancer is one of the most common malignant disease worldwide with highly metastatic potential. Identification of effective therapeutic treatment overcoming such disease is urgent need. Our study focuses on hinokiflavone as an anti-tumor agent against colorectal cancer. METHODS: MTT assay, cell colony formation assay, Hoechst staining, flow cytometer, western blot analysis, real-time PCR, migration and invasion assay were performed to identify effects of hinokiflavone on cell proliferation, apoptosis and metastasis...
December 21, 2018: Journal of Gastroenterology and Hepatology
Jiahui Yang, Xin Wang, Yarui Li, Guifang Lu, Xinlan Lu, Dan Guo, Wancong Wang, Chuan Liu, Ye Xiao, Nini Han, Shuixiang He
OBJECTIVE: Even though Endoscopic submucosal dissection (ESD) is an important endoscopic resection technique for gastrointestinal neoplasms, there are chances that postoperative esophageal stricture might take place as a side effect. Steroid applications were reported to be effective for the prevention of stricture formation. Therefore, this study aims to evaluate the efficacy and safety of different steroid applications. METHODS: Eligible studies published on PubMed, the Cochrane Library, Embase, Web of Science and Chinese Biomedical Literature Database before Aug...
December 19, 2018: Journal of Gastroenterology and Hepatology
R N Lopez, Y Al Rawahi, M Stormon, M Chennapragada, Chee Y Ooi
No abstract text is available yet for this article.
December 18, 2018: Journal of Gastroenterology and Hepatology
R Hashimoto, T Matsuda
No abstract text is available yet for this article.
December 18, 2018: Journal of Gastroenterology and Hepatology
L Hillman, P Jeans, P Whiting
No abstract text is available yet for this article.
December 18, 2018: Journal of Gastroenterology and Hepatology
Johan Burisch, Stefania Chetcuti Zammit, Pierre Ellul, Svetlana Turcan, Dana Duricova, Martin Bortlik, Karina Winther Andersen, Vibeke Andersen, Ioannis P Kaimakliotis, Mathurin Fumery, Corinne Gower-Rousseau, Giulia Girardin, Daniela Valpiani, Adrian Goldis, Marko Brinar, Silvija Čuković-Čavka, Pia Oksanen, Pekka Collin, Luisa Barros, Fernando Magro, Ravi Misra, Naila Arebi, Carl Eriksson, Jonas Halfvarson, Hendrika Adriana Linda Kievit, Natalia Pedersen, Jens Kjeldsen, Sally Myers, Shaji Sebastian, Konstantinos H Katsanos, Dimitrios K Christodoulou, Jóngerð Midjord, Kári Rubek Nielsen, Gediminas Kiudelis, Limas Kupcinskas, Inna Nikulina, Elena Belousova, Doron Schwartz, Selwyn Odes, Riina Salupere, Amalia Carmona, Juan R Pineda, Zsuzsanna Vegh, Peter L Lakatos, Ebbe Langholz, Pia Munkholm
BACKGROUND: A definitive diagnosis of Crohn's disease (CD) or ulcerative colitis (UC) is not always possible and a proportion of patients will be diagnosed as inflammatory bowel disease unclassified (IBDU). The aim of the study was to investigate the prognosis of patients initially diagnosed with IBDU and the disease course during the following five years. METHODS: The Epi-IBD study is a prospective population-based cohort of 1,289 IBD patients diagnosed in centres across Europe...
December 18, 2018: Journal of Gastroenterology and Hepatology
Taro Iwatsubo, Ryu Ishihara, Kentaro Nakagawa, Masayasu Ohmori, Hiroyoshi Iwagami, Kenshi Matsuno, Shuntaro Inoue, Hiroko Nakahira, Noriko Matsuura, Satoki Shichijo, Akira Maekawa, Takashi Kanesaka, Sachiko Yamamoto, Yoji Takeuchi, Koji Higashino, Noriya Uedo, Kazuhide Higuchi
BACKGROUND AND AIM: Simultaneous and metachronous head and neck cancers are likely to develop in patients with current or previous esophageal cancer. The Valsalva maneuver facilitates the visualization of the hypopharyngeal area during endoscopic observation, but it requires transnasal endoscopy. We developed a novel Valsalva maneuver using transoral endoscopy with a lip cover-type mouthpiece. METHODS: Between March 2018 and July 2018, 107 patients with current or previous esophageal cancer who were scheduled to undergo upper gastrointestinal endoscopy were included in our pilot study...
December 18, 2018: Journal of Gastroenterology and Hepatology
Nam Hee Kim, Yoon Suk Jung, Jung Ho Park, Dong Il Park, Chong Il Sohn
BACKGROUND AND AIM: The relationship between a family history of colorectal cancer (CRC) and the risk of metachronous colorectal neoplasia (CRN) following polypectomy remains unknown. We aimed to compare the risk of metachronous CRN according to CRC family history in groups of patients aged <50 and ≥50 years. METHODS: We studied patients who underwent ≥1 adenoma removal between 2010 and 2014 and follow-up surveillance colonoscopic examinations until 2017...
December 16, 2018: Journal of Gastroenterology and Hepatology
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