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Journal of Gastroenterology and Hepatology

Zhaohua Shen, Changxin Zhu, Yongsheng Quan, Jinming Yang, Wei Yuan, Zhenyu Yang, Shuai Wu, Weiwei Luo, Bei Tan, Xiaoyan Wang
BACKGROUND AND AIM: To elucidate the anti-inflammatory effect and mechanism of Roseburia intestinalis (R.intestinalis) in Crohn's disease (CD). METHODS: 16S-rRNA genome sequencing technique is used to detect the characteristics of intestinal microbiota in untreated CD patients and healthy controls. Then we investigate the effects of R.intestinalis on disease activity index (DAI) score, intestinal pathology, the differentiation of Treg cells and the expressions of TSLP, TGF-β, IL-10 by using TNBS colitis models...
March 12, 2018: Journal of Gastroenterology and Hepatology
Ming-Te Kuo, Po-Lin Tseng, Yeh-Pin Chou, Kuo-Chin Chang, Ming-Chao Tsai, Yuan-Hung Kuo, Tsung-Hui Hu, Chao-Hung Hung, Jing-Houng Wang, Sheng-Nan Lu, Chien-Hung Chen
BACKGROUND AND AIM: This study investigated whether hepatitis B surface antigen (HBsAg) could predict HBV relapse after cessation of entecavir or tenofovir disoproxil fumarate (TDF) prophylaxis for chronic hepatitis B (CHB) cancer patients who are undergoing chemotherapy. METHODS: The study enrolled 122 hepatitis B e antigen (HBeAg)-negative cancer patients who underwent chemotherapy with entecavir or TDF for anti-viral prophylaxis and post-treatment follow-up for at least 6 months...
March 7, 2018: Journal of Gastroenterology and Hepatology
Monica Chowdhry, Kuldeep Shah, Suzanne Kemper, David Zekan, William Carter, Brittain McJunkin
BACKGROUND: Proton pump inhibitors are among the most commonly prescribed medications worldwide, with dramatic efficacy for upper GI acid related disorders. In recent years, however, the safety of long-term PPI use has been questioned. One issue based on scant and conflicting literature is the possibility of PPI related hypomagnesemia. Our purpose was to assess for any clinically significant alteration in serum magnesium levels in large groups of patients taking different PPIs in varying doses, with or without diuretics...
March 7, 2018: Journal of Gastroenterology and Hepatology
Hidetoshi Takedatsu, Keiichi Mitsuyama, Shuhei Fukunaga, Shinichiro Yoshioka, Ryosuke Yamauchi, Atsushi Mori, Hiroshi Yamasaki, Kotaro Kuwaki, Hideto Sakisaka, Shotaro Sakisaka, Takuji Torimura
BACKGROUND AND AIM: Proteinase 3 antineutrophil cytoplasmic antibodies (PR3-ANCAs) are well-known serological markers for granulomatosis with polyangiitis, but their role as serological markers for inflammatory bowel disease (IBD) remains uncertain. The present study aimed to evaluate the diagnostic and clinical role of PR3-ANCAs as markers for IBD. METHODS: Using a new methodology with chemiluminescence enzyme immunoassay, serum PR3-ANCA titres were assessed in 102 patients with ulcerative colitis (UC), 67 patients with Crohn's disease (CD), 44 controls with other intestinal diseases and 66 healthy controls...
March 7, 2018: Journal of Gastroenterology and Hepatology
Jinwoo Kang, Ji Kon Ryu, Jun Hyuk Son, Jae-Woo Lee, Jin Ho Choi, Sang Hyub Lee, Yong-Tae Kim
BACKGROUND: Pancreatic neuroendocrine neoplasms (PanNENs) are rare diseases but gradually increasing in prevalence with different prognosis. Multiphase contrast-enhanced computed tomography (CT) is known as widely used imaging modality for the diagnosis of pancreatic tumors. We aimed to investigate whether CT enhancement pattern is associated with the pathologic tumor grade and can predict that of pancreatic neuroendocrine neoplasm. METHODS: Ninety PanNEN patients who underwent multi-phase enhanced CT before pathologic diagnosis were retrospectively reviewed...
March 7, 2018: Journal of Gastroenterology and Hepatology
Khean-Lee Goh
The study of Helicobacter pylori in Malaysia has given several important insights into the epidemiology of the infection and pathogenesis of disease. Malaysia has a multiracial Asian population with three major Asian races living together- Malay, Chinese and Indian. Races remain fairly distinct because of a paucity of inter-racial marriages. The "Racial Cohort Hypothesis" proposes that the infection occurs within racial groups rather than between. As such the high prevalence amongst Indians (>50%) and Chinese (40-50%) reflects the high prevalence in their countries of origin even though migration had taken place more than two generations before...
March 2, 2018: Journal of Gastroenterology and Hepatology
Yoshihiko Tachi, Akihiro Kozuka, Takanori Hirai, Yoji Ishizu, Takashi Honda, Teiji Kuzuya, Kazuhiko Hayashi, Masatoshi Ishigami, Hidemi Goto
BACKGROUND AND AIMS: Severe muscle volume loss is a recognized negative prognostic factor in patients with chronic liver disease. However, the effect of skeletal muscle fat deposition, referred to as myosteatosis on muscle volume loss remains unclear. The aim of this study was to investigate the relationships between myosteatosis and skeletal muscle volume loss. METHODS: We enrolled 362 patients with chronic liver disease (186 men, 176 women; mean age 68.4 ± 10...
February 27, 2018: Journal of Gastroenterology and Hepatology
Sharon Carey, Michelle Kalachov, Lynn Jones, Cherry Koh
BACKGROUND AND AIM: To establish consensus on service delivery models for management of Type III intestinal failure (IF) and home parenteral nutrition (HPN) within the Australian health care system and to identify barriers and enablers in moving towards this ideal model. METHODS: A modified Delphi methodology was utilised to survey experts working in Type III IF HPN. The panel comprised physicians, dietitians, nurses and pharmacists from 18 of the 20 adult Type III IF HPN centres across Australia...
February 27, 2018: Journal of Gastroenterology and Hepatology
Yuji Eso, Atsushi Takai, Kojiro Taura, Ken Takahashi, Yoshihide Ueda, Hiroyuki Marusawa, Hiroshi Seno
BACKGROUND AND AIM: Mac-2-binding protein glycosylation isomer (M2BPGi) was recently identified as a serum glycobiomarker for liver fibrosis. However, the relationship between M2BPGi and malnutrition in patients with chronic liver disease (CLD) is unknown. We aimed to evaluate whether M2BPGi could be a surrogate marker for malnutrition in patients with CLD. METHODS: In total, 338 outpatients with CLD were enrolled (median age: 67 years). We evaluated the associations among liver fibrosis markers (M2BPGi, FIB-4 index, and aspartate aminotransferase to platelet count ratio index), Child-Pugh stages, and nutritional status markers...
February 22, 2018: Journal of Gastroenterology and Hepatology
Atsushi Hirano, Junji Umeno, Yasuharu Okamoto, Hiroki Shibata, Yoshitoshi Ogura, Tomohiko Moriyama, Takehiro Torisu, Shin Fujioka, Yuta Fuyuno, Yutaka Kawarabayasi, Takayuki Matsumoto, Takanari Kitazono, Motohiro Esaki
BACKGROUND AND AIM: The gut microbiota is suggested to play an important role in the pathogenesis of ulcerative colitis (UC). However, inter-individual and spatial variations hamper the identification of UC-related changes. We thus investigated paired mucosa-associated microbiota obtained from both inflamed and non-inflamed sites of UC patients and corresponding sites of non-IBD controls. METHODS: Mucosal biopsies of both inflamed and non-inflamed sites were obtained from 14 patients with active UC of the left-sided or proctitis type...
February 20, 2018: Journal of Gastroenterology and Hepatology
Tae Hyung Kim, Dae Hoe Ku, Soon Ho Um, Han Ah Lee, Seung Woon Park, Jung Mi Chang, Sun Young Yim, Sang Jun Suh, Young Kul Jung, Yeon Seok Seo, Ji Hoon Kim, Hyung Joon Yim, Jong Eun Yeon, Kwan Soo Byun, Hyonggin Ahn
BACKGROUND AND AIM: We aimed to develop a more efficient prognostic model to predict 1-year mortality in patients with hepatitis B virus (HBV)-related decompensated cirrhosis beginning antiviral treatment. METHODS: Using Cox regression analysis, survival analyses were performed on 554 patients with decompensated cirrhosis who were followed up from the start of nucleos(t)ide analogue antiviral treatment. RESULTS: At baseline, ascites and hepatic encephalopathy were found in 78...
February 20, 2018: Journal of Gastroenterology and Hepatology
Alan J Wigg, Jong K Chin, Kate R Muller, Jeyamani Ramachandran, Richard J Woodman, Billingsley Kaambwa
Background and Aims In this follow-up study to a RCT of chronic a chronic disease management (CDM) model in cirrhosis, our aim was to assess the relative cost effectiveness of this model compared to usual care during the 12-month study period, using incremental costs per death avoided as the primary outcome. METHODS: Mean differences in hospitalization costs, deaths avoided and change in Chronic Liver Disease Questionnaire (CLDQ) total scores were presented with 95% non-parametric bootstrapped confidence intervals...
February 20, 2018: Journal of Gastroenterology and Hepatology
Toru Yamada, Yoshitsugu Nakanishi, Keisuke Okamura, Takahiro Tsuchikawa, Toru Nakamura, Takehiro Noji, Toshimichi Asano, Kimitaka Tanaka, Yo Kurashima, Yuma Ebihara, Soichi Murakami, Toshiaki Shichinohe, Tomoko Mitsuhashi, Satoshi Hirano
BACKGROUND AND AIM: Lymph node metastasis is an important prognostic factor for intrahepatic cholangiocarcinoma (ICC), but accurate preoperative diagnosis is difficult. The aim of this study was to measure the concentration of serum carbohydrate antigen 19-9 (s-CA19-9) as a preoperative predictor of lymph node metastasis. METHODS: In our department, curative-intent hepatectomy for ICC has been performed only once the absence of metastases in para-aortic lymph nodes (PALN) has been confirmed from intraoperative frozen-section pathological examinations...
February 10, 2018: Journal of Gastroenterology and Hepatology
Hiroyoshi Doi, Eiichi Hayashi, Jun Arai, Masayuki Tojo, Kenichi Morikawa, Junichi Eguchi, Takayoshi Ito, Tatsuya Kanto, David E Kaplan, Hitoshi Yoshida
BACKGROUND AND AIM: The mechanism underlying hyperglobulinemia in cirrhosis, a long appreciated phenomenon, has never been clearly understood. The aim of this study is to investigate the basis for changes in humoral immunity observed in cirrhosis. METHODS: We retrospectively reviewed our medical record to analyze serum immunoglobulin levels in patients with liver disease. We also prospectively analyzed peripheral blood mononuclear cells (PBMC) and sera from liver disease patients...
February 10, 2018: Journal of Gastroenterology and Hepatology
Webber Chan Pak Wo, Fadi Mourad, Rupert W L Leong
Crohn's disease (CD) is a chronic relapsing and remitting disease that can affect any segments of the gastrointestinal (GI) tract. More than 50% of patients with CD develop stricturing or penetrating complications within the first 10 years after diagnosis. Strictures can lead to intestinal obstruction, which is a common indication for surgery. Despite significant advances in the understanding of the pathogenesis of intestinal fibrostenosis, imaging and therapeutic armamentarium of CD, the risk of intestinal surgery remained significantly high...
February 10, 2018: Journal of Gastroenterology and Hepatology
Cong Dai, Min Jiang, Ming-Jun Sun, Qin Cao
OBJECTIVE: Fecal immunochemical test (FIT) is a promising marker for assessment of inflammatory bowel disease (IBD) activity. However, the utility of FIT for predicting mucosal healing (MH) of Ulcerative Colitis (UC) patients has yet to be clearly demonstrated. The objective of our study was to perform a diagnostic test accuracy test meta-analysis evaluating the diagnostic accuracy of FIT in predicting MH of UC patients. METHODS: We systematically searched the databases from inception to November 2017 that evaluated MH in UC...
February 10, 2018: Journal of Gastroenterology and Hepatology
Fahrettin Haczeyni, Matthew M Yeh, George N Ioannou, Isabelle A Leclercq, Robert Goldin, Yock Young Dan, Jun Yu, Narcissus C Teoh, Geoffrey C Farrell
Nonalcoholic steatohepatitis (NASH) is strongly associated with overnutrition, insulin resistance, and predisposition to type 2 diabetes. To critically analyze the translational significance of currently-used animal models of NASH, we reviewed articles published during the last three years that studied NASH pathogenesis using mouse models. Among 146 articles, 34 (23%) used models in which overnutrition was reported, and 36 (25%) demonstrated insulin resistance, with or without glucose intolerance. Half the articles contained no information on whether mice exhibited overnutrition or insulin resistance...
February 9, 2018: Journal of Gastroenterology and Hepatology
Nozomi Okuno, Kazuo Hara, Nobumasa Mizuno, Takamichi Kuwahara, Hiromichi Iwaya, Ayako Ito, Naosuke Kuraoka, Shinpei Matsumoto, Petcharee Polmanee, Yasumasa Niwa
BACKGROUND AND AIM: EUS-guided hepaticogastrostomy (EUS-HGS) is performed as an alternative to the percutaneous or surgical approach. Despite high success rates, the adverse events rate is high. Recently, we used 6-mm fully-covered self-expandable metal stents (FCSEMS) to prevent adverse events and allow easy re-intervention. The purposes were to evaluate the safety, feasibility and clinical efficacy. METHODS: A prospective study to confirm the safety of EUS-HGS was carried out in six patients, followed by a trial to evaluate the feasibility and efficacy of EUS-HGS in approximately 12 additional patients...
February 9, 2018: Journal of Gastroenterology and Hepatology
Christopher Sung-Huan Yeh, Chao-Wei Hsu, Kung-Hao Liang, Yi-Cheng Chen, Chih-Lang Lin, Rong-Nan Chien, Tsung-Hui Hu, Wey-Ran Lin, Ming-Wei Lai, Yu-De Chu, Chau-Ting Yeh
BACKGROUND AND AIM: Commonly used non-invasive fibrosis scores usually included serum transaminase levels in the equations, including aspartate-to-platelet-ratio-index (APRI) and fibrosis-4 (FIB-4). Transaminases fluctuated significantly in chronic hepatitis B (CHB) patients with exacerbations, leading to unsteady score values. As such, here, we aim to develop a transaminase-free score suitable for pretherapeutic evaluation of fibrosis stages. METHODS: Firstly, 1082 treatment-naïve CHB patients were enrolled and divided into modeling (n = 541) and verification (n = 541) cohorts...
February 8, 2018: Journal of Gastroenterology and Hepatology
Jun Chul Park, Yeong Jin Kim, Eun Hye Kim, Jinae Lee, Hyun Su Yang, Eun Hwa Kim, Kyu Yeon Hahn, Sung Kwan Shin, Sang Kil Lee, Yong Chan Lee
BACKGROUND AND AIM: Recently, the application of hemostatic powder to the bleeding site has been used to treat active upper gastrointestinal bleeding (UGIB). We aimed to assess the effectiveness of the polysaccharide hemostatic powder (PHP) in patients with non-variceal UGIB. METHODS: We reviewed prospectively collected 40 patients with UGIB treated with PHP therapy between April 2016 and January 2017 (PHP group) and 303 patients with UGIB treated with conventional therapy between April 2012 and October 2014 (conventional therapy group)...
February 7, 2018: Journal of Gastroenterology and Hepatology
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