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Journal of Gastroenterology and Hepatology

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https://www.readbyqxmd.com/read/28548299/a-noninvasive-diagnosis-of-hepatic-fibrosis-by-biofibroscore%C3%A2-in-chronic-hepatitis-c-patients
#1
Chen-Hua Liu, Chun-Jen Liu, Chun-Ming Hong, Tung-Hung Su, Hung-Chih Yang, Kuei-Ming Chen, Yi-Ping Huang, Yu-Ming Yeh, Hui-Lan Tien, Yuan-Chih Liu, Jia-Horng Kao, Ding-Shinn Chen, Pei-Jer Chen
BACKGROUND & AIMS: The diagnostic accuracy of a novel serological panel (BioFibroScore®) to predict hepatic fibrosis in patients with chronic hepatitis C virus (HCV) infection is unknown. METHODS: Three markers of BioFibroScore®, including urokinase plasminogen activator (uPA), matrix metalloproteinase-9 (MMP-9), and beta-2 microglobulin (β2M), were retrospectively evaluated in 635 HCV-infected patients who received percutaneous liver biopsy and FibroScan®. The formula of BioFibroScore® to predict the severity of hepatic fibrosis was developed by Adaboost algorithm...
May 26, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28544091/a-new-predictive-model-for-acute-gastrointestinal-bleeding-in-patients-taking-oral-anticoagulants-a-cohort-study
#2
Akira Shimomura, Naoyoshi Nagata, Takuro Shimbo, Toshiyuki Sakurai, Shiori Moriyasu, Hidetaka Okubo, Kazuhiro Watanabe, Chizu Yokoi, Junichi Akiyama, Naomi Uemura
BACKGROUND: We developed a predictive model of long-term gastrointestinal (GI) bleeding risk in patients receiving oral anticoagulants and compared it with the HAS-BLED score. METHODS: We periodically followed a cohort of 508 patients taking oral anticoagulants (66 direct oral anticoagulants users and 442 warfarin users). Absence of GI bleeding at an initial examination, and any subsequent GI bleeding, were confirmed endoscopically. The bleeding model was developed by multivariate survival analysis and evaluated by Harrell's c-index...
May 19, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28543841/role-of-fluorescence-in-situ-hybridization-in-diagnosing-cholangiocarcinoma-in-indeterminate-biliary-strictures
#3
Z H Liew, T J Z Loh, T K H Lim, T H Lim, C J L Khor, S J Mesenas, C S C Kong, W C Ong, D M Y Tan
BACKGROUND: Brush cytology, the conventional method to diagnose cholangiocarcinoma, has been plagued by low diagnostic sensitivity and false-negative results. We aim to study the clinical utility of fluorescence in situ hybridization (FISH) in enhancing identification of malignant biliary strictures. METHODS: Brush cytologic specimens collected from endoscopic retrograde cholangiopancreatography (ERCP) for biliary strictures in a tertiary hospital in Singapore from March 2013 to July 2015 were examined by FISH technique using UroVysion probe set in this study...
May 19, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28543366/clinical-characteristics-and-long-term-prognosis-of-elderly-onset-ulcerative-colitis
#4
Eun Mi Song, Ho-Su Lee, Sang Hyoung Park, Gwang Un Kim, Myeong Sook Seo, Sung Wook Hwang, Dong-Hoon Yang, Kyung-Jo Kim, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Byong Duk Ye
BACKGROUND: The aim of this study was to investigate the clinical characteristics and prognosis of patients with elderly-onset ulcerative colitis (EOUC), a new growing subgroup of UC. METHODS: We retrospectively analyzed 3,060 South Korean UC patients diagnosed between 1977 and 2014. The clinical characteristics and prognosis of EOUC, defined as UC in those aged ≥ 60 years at diagnosis, were compared to those of non-elderly-onset UC (NEOUC). RESULTS: Among the 3,060 patients, 226 were diagnosed with EOUC (7...
May 19, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28497645/peptic-ulcer-bleeding-patients-with-rockall-scores-%C3%A2-6-are-at-risk-of-long-term-ulcer-rebleeding-a-3-5-year-prospective-longitudinal-study
#5
Er-Hsiang Yang, Hsiu-Chi Cheng, Chung-Tai Wu, Wei-Ying Chen, Meng-Ying Lin, Bor-Shyang Sheu
BACKGROUND: Patients with high Rockall scores have increased risk of rebleeding and mortality within 30 days after peptic ulcer bleeding, but long-term outcomes deserve follow-up after cessation of proton-pump inhibitors (PPIs). AIM: To validate whether patients with high Rockall scores have more recurrent ulcer bleeding in a 3.5-year longitudinal cohort. METHODS: Between August, 2011 and July, 2014, 368 patients with peptic ulcer bleeding were prospectively enrolled after endoscopic hemostasis to receive PPIs for at least 8 to 16 weeks...
May 11, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28497593/polymorphism-of-receptor-type-tyrosine-protein-phosphatase-delta-gene-in-the-development-of-non-alcoholic-fatty-liver-disease
#6
Shunsuke Nakajima, Hiroki Tanaka, Koji Sawada, Hidemi Hayashi, Takumu Hasebe, Masami Abe, Chitomi Hasebe, Mikihiro Fujiya, Toshikatsu Okumura
BACKGROUND AND AIM: Some single nucleotide polymorphisms (SNPs) are associated with the development of non-alcoholic fatty liver disease (NAFLD). As one of the genetic factors, PNPLA3 rs738409 (I148M) is important to associate with pathogenesis of NAFLD. Since other SNPs remain unclear in Japan, we performed high-throughput sequencing, which targeted more than 1,000 genes to identify a novel genetic variant in Japanese patients with NAFLD. METHODS: The present study in 36 NAFLD patients and 27 healthy volunteers (HVs) was performed...
May 11, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28497589/the-asia-pacific-colorectal-screening-score-is-useful-to-stratify-risk-for-colorectal-advanced-neoplasms-in-vietnamese-patients-with-irritable-bowel-syndrome
#7
Duc Trong Quach, Toru Hiyama, Thu Anh Nguyen, Hoa Quoc Ly, Shinji Tanaka
BACKGROUND: The Asia Pacific Colorectal Screening (APCS) score has been validated in several populations but not yet in patients with irritable bowel syndrome (IBS). AIM: To assess the performance of APCS score in stratifying risk of colorectal advanced neoplasms (CAN) in Vietnamese IBS patients. METHODS: Consecutive patients who fulfilled IBS diagnosis criteria according to the Rome III were prospectively enrolled and underwent colonoscopy...
May 11, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28488376/a-predictive-formula-of-coma-onset-and-prothrombin-time-to-distinguish-patients-who-recover-from-acute-liver-injury
#8
Keisuke Kakisaka, Yuji Suzuki, Kojiro Kataoka, Yohei Okada, Yasuhiro Miyamoto, Hidekatsu Kuroda, Yasuhiro Takikawa
BACKGROUND & AIM: Acute liver failure (ALF) is defined as acute liver injury (ALI) associated with coagulopathy. A follow-up strategy for ALI and characterization of ALI patients with a risk of progressing to ALF have never been established. To establish predictive markers for progression from ALI to ALF, we compared the clinical characteristics and laboratory data on the day of registration to data from a regional referral system of patients with ALI. METHODS: This prospective, observational study enrolled 365 consecutive patients with ALI/ALF between 2007 and 2016...
May 9, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28482378/high-expression-of-tumor-necrosis-factor-receptor-associated-factor-2-promotes-tumor-metastasis-and-is-associated-with-unfavorable-prognosis-in-gastric-cancer
#9
Junjie Zhao, Haojie Li, Lingqiang Min, Xu Han, Ping Shu, Yupeng Yang, Qiangjun Gan, Xuefei Wang, Hongshan Wang, Yuanyuan Ruan, Jing Qin, Yihong Sun, Xinyu Qin
BACKGROUND: Tumor necrosis factor receptor-associated factor 2 (TRAF2) is a key effector in the activation of nuclear factor kappa B (NF-κB). Nevertheless, the role of TRAF2 in gastric tumorigenesis remains little defined. METHODS: Immunohistochemistry (IHC) was used to find the relationship between TRAF2 expression and clinicopathological characteristics of gastric cancer (GC) patients, and nomogram was applied to predict the overall survival of patients. Besides, we performed transwell assays to detect the function of TRAF2 in promoting metastasis, and explored the correlations between TRAF2, NF-κB, and interleukin-8 (IL-8) in vitro...
May 8, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28475827/muscular-thickness-of-lower-esophageal-sphincter-and-therapeutic-outcomes-in-achalasia-a-prospective-study-using-high-frequency-endoscopic-ultrasound
#10
Shih-Wei Li, Ping-Huei Tseng, Chien-Chuan Chen, Wei-Chih Liao, Kao-Lang Liu, Jang-Ming Lee, Yi-Chia Lee, Seng-Kee Chuah, Ming-Shiang Wu, Hsiu-Po Wang
BACKGROUND AND AIM: Patients with achalasia typically have thicker lower esophageal sphincter muscles, which can affect the distensibility of the esophagogastric junction. We aimed to assess whether these muscular features, measured using high-frequency endoscopic ultrasound, affect treatment outcomes. METHODS: Consecutive adult patients with suspected achalasia were enrolled prospectively. They underwent a comprehensive diagnostic work-up, including endoscopic ultrasound...
May 5, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28475826/effect-of-oral-tobacco-use-and-smoking-on-outcomes-of-crohn-s-disease-in-india
#11
Umang Arora, Ashwin N Ananthakrishnan, Saurabh Kedia, Sawan Bopana, P V Mouli, Dawesh P Yadav, Govind K Makharia, Vijay Yajnik, Vineet Ahuja
INTRODUCTION: Smoking has been linked with adverse outcomes in Crohn's disease(CD), however it is not known whether oral tobacco use affects disease outcomes in these patients. The study aimed to assess the association between smoking or oral tobacco(OT) and outcomes in CD. METHODS: Retrospective analysis was performed on prospectively maintained records of CD patients from 2004-2016. The parameters assessed included disease characteristics at baseline(location, behavior, age at onset, perianal disease, extra-intestinal manifestations), course pattern and outcomes (surgery, hospitalizations, immunomodulator or biologics use, and steroid requirement)...
May 5, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28475813/direct-health-care-cost-utilization-in-hong-kong-inflammatory-bowel-disease-patients-in-the-initial-2-years-following-diagnosis
#12
Lung-Yi Mak, Siew C Ng, Irene O L Wong, Michael K K Li, F H Lo, Marc T L Wong, C M Leung, Steven W C Tsang, K H Chan, S F Sze, Edwin H S Shan, Belsy C Y Lam, Aric J Hui, Ivan F N Hung, Wai K Leung
BACKGROUND AND AIM: There is scanty data on the healthcare utilization from Asia where the incidence of inflammatory bowel disease (IBD) is rising rapidly. We aim to determine the direct healthcare costs in the first two-year of diagnosis in an IBD cohort from Hong Kong, and the factors associated with high cost-outliers. METHODS: This is a retrospective cohort study which included patients newly diagnosed with IBD in a territory-wide IBD registry. Patients' clinical information, hospitalization records, investigations and IBD treatments were retrieved for up to two years following diagnosis of IBD...
May 5, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28464337/fatty-liver-index-and-hepatic-steatosis-index-predict-non-alcoholic-fatty-liver-disease-in-type-1-diabetes
#13
Laura Sviklāne, Evija Olmane, Zane Dzērve, Kārlis Kupčs, Valdis Pīrāgs V, Jelizaveta Sokolovska
BACKGROUND AND AIM: Little is known about the diagnostic value of hepatic steatosis index (HSI) and fatty liver index (FLI), as well as their link to metabolic syndrome in type 1 diabetes mellitus. We have screened the effectiveness of FLI and HSI in an observational pilot study of 40 patients with type 1 diabetes. METHODS: FLI and HSI indices were calculated for 201 patients with type 1 diabetes. 40 patients with FLI/HSI values corresponding to different risk of liver steatosis were invited for liver magnetic resonance study...
May 2, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28452428/impact-of-gluten-consumption-in-patients-with-functional-dyspepsia-a-case-control-study
#14
Lijun Du, Jinhua Shen, John J Kim, Huiqin He, Binrui Chen, Ning Dai
BACKGROUND AND AIM: Dietary factors and immune dysfunction may induce symptoms in patients with functional dyspepsia (FD). Aim of the study was to evaluate whether gluten consumption impacts symptom onset in patients with FD and to evaluate for possible histologic alterations in the duodenum of patients with FD. METHODS: We prospectively enrolled 101 patients newly diagnosed with FD and 31 asymptomatic controls. Specific FD symptoms and gluten consumption patterns were evaluated by self-reported questionnaires...
April 28, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28452125/stepwise-application-of-fib-4-red-cell-distribution-width-platelet-ratio-and-apri-for-compensated-hepatitis-b-fibrosis-detection
#15
Yong-Peng Chen, Xiao-Min Hu, Xie-Er Liang, Li-Wen Huang, You-Fu Zhu, Jin-Lin Hou
AIM: FIB-4 and APRI were validated with unsatisfactory efficiency. Routine hematology in-dex red cell distribution width-platelet ratio (RPR) had been tried in Liver Fibrosis detection. This study tries to evaluate the stepwise application of FIB-4, RPR and APRI in detecting CHB fibrosis. METHODS: A total of 246 compensated CHB patients underwent liver biopsies, transient elas-tography and routine blood tests including complete blood count were included. Dual Cutoffs were determined to exclude or include cirrhosis diagnosis...
April 28, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28452067/zinc-monotherapy-for-young-children-with-presymptomatic-wilson-disease-a-multicenter-study-in-japan
#16
Keisuke Eda, Tatsuki Mizuochi, Itaru Iwama, Ayano Inui, Yuri Etani, Mariko Araki, Shinya Hara, Hideki Kumagai, Shin-Ichiro Hagiwara, Kei Murayama, Jun Murakami, Norikazu Shimizu, Hiroko Kodama, Ryosuke Yasuda, Yugo Takaki, Yushiro Yamashita
BACKGROUND AND AIM: Few studies of zinc monotherapy for presymptomatic Wilson disease have focused on young children. We therefore evaluated long-term efficacy and safety of zinc monotherapy for such children, and established benchmarks for maintenance therapy. METHODS: We retrospectively and prospectively examined children under 10 years old with presymptomatic Wilson disease who received zinc monotherapy from time of diagnosis at 12 participating pediatric centers in Japan...
April 28, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28444800/endoscopic-meatus-scoring-scale-versus-sniff-test-to-predict-insertability-before-transnasal-endoscopy-a-prospective-randomized-study
#17
Chi-Tan Hu, Wei-Yi Lei, Jen-Shung Lin, Jui-Sheng Hung
BACKGROUND AND AIM: Sniff test is a common method before unsedated transnasal EGD (UT-EGD) to select a nostril insertion site. Yet, there is no objective method to select a more specific meatus insertion tract for anesthesia and insertion. We devised a endoscopic meatus scoring scale by anterior meatuscopy to select the most optimal meatus insertion tract. We hypothesized that meatuscopy instead of sniff test might improve tolerance and reduce adverse events during nasal anesthesia and UT-EGD...
April 26, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28440889/a-glucagon-like-peptide-1-analog-liraglutide-improves-visceral-sensation-and-gut-permeability-in-rats
#18
Tsukasa Nozu, Saori Miyagishi, Shima Kumei, Rintaro Nozu, Kaoru Takakusaki, Toshikatsu Okumura
BACKGROUND AND AIM: A glucagon-like peptide-1 (GLP-1) analog, liraglutide, has been reported to block inflammatory somatic pain. We hypothesized that liraglutide attenuates lipopolysaccharide (LPS)- and repeated water avoidance stress (WAS)-induced visceral hypersensitivity and tested the hypothesis in rats. METHODS: The threshold of the visceromotor response (VMR) induced by colonic balloon distention was measured to assess visceral sensation. Colonic permeability was determined in vivo by quantifying the absorbed Evans blue spectrophotometrically, which was instilled in the proximal colon for 15 min...
April 25, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28440885/a-comparison-of-direct-sequencing-and-invader-assay-for-y93h-mutation-and-response-to-interferon-free-therapy-in-hepatitis-c-virus-genotype-1b
#19
Kazuhiko Hayashi, Masatoshi Ishigami, Yoji Ishizu, Teiji Kuzuya, Takashi Honda, Hiroki Kawashima, Tetsuya Ishikawa, Yoshihiko Tachi, Masashi Hattori, Yoshiaki Katano, Hidemi Goto, Yoshiki Hirooka
BACKGROUND AND AIM: Virologic failure of interferon (IFN)-free therapy has been associated with Y93H mutation in the NS5A region in hepatitis C virus (HCV) genotype 1b, and screening is recommended. A simple assay based on Q-Invader technology was developed for Y93H mutant screening to reduce cost and effort. The present study sought to compare two methods of detection of Y93H mutation and to evaluate the effect of Y93H mutation on response to IFN free therapy. METHODS: Y93H mutation was examined in 258 patients with HCV genotype 1b using both direct sequencing analysis and the PCR-Invader assay...
April 25, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28431454/da-9701-improves-colonic-transit-time-and-symptoms-in-patients-with-functional-constipation-a-prospective-study
#20
Su Young Kim, Hyun Sun Woo, Sung Han Choi, Dong Kyun Park, Kwang An Kwon, Jun-Won Chung, Yoon Jae Kim, Jung Ho Kim, Su Ji Kim, Kyoung Oh Kim
BACKGROUND AND AIM: DA-9701, a newly developed prokinetic agent formulated with Pharbitis Semen and Corydalis Tuber, has been shown to effectively treat functional dyspepsia. Recently, it has also been suspected to improve gastrointestinal motor function. The aims of this study were to assess the effect of DA-9701 on colonic transit time (CTT) and symptoms of functional constipation. METHODS: We prospectively enrolled 33 patients with functional constipation based on the Rome III criteria...
April 21, 2017: Journal of Gastroenterology and Hepatology
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