Read by QxMD icon Read

Journal of Gastroenterology and Hepatology

Guolin Li, Chad N Brocker, Cen Xie, Tingting Yan, Audrey Noguchi, Kristopher W Krausz, Rong Xiang, Frank J Gonzalez
BACKGROUND AND AIM: Peroxisome proliferator-activated receptor alpha (PPARα) is a molecular target of various fibrate drugs clinically used to lower serum lipids. However, the tissue-specific functions of PPARα remain to be elucidated. This study aimed to explore the tissue-specific functions of PPARα in response to Wy-14643. METHODS: A hepatocyte-specific Ppara knockout mouse line was used to explore the impact of hepatic PPARα activity on the systemic response to treatment with the potent PPARα agonist Wy-14643...
November 15, 2017: Journal of Gastroenterology and Hepatology
Jong Min Park, Sang Hwan Lee, Kwang Il Kim, Won Hee Kim, Joo Young Cho, Ki Baik Hahm, Sung Pyo Hong
BACKGROUND/AIMS: Diabetic gastropathy is associated with loss of Interstitial cells of Cajal (ICCs) and autonomic neuropathy. Effective management for diabetic gastropathy is still unavailable. This study was aimed to confirm the pathogenetic changes in diabetic gastropathy and to examine the effect of treatment with placental derived mesenchymal stem cells (PDMSCs) in stomachs of animal models. METHODS: Fourteen NOD/ShiLtJ mice of 8 weeks were bled until week 30...
November 15, 2017: Journal of Gastroenterology and Hepatology
Michaela Müller, Christina Keck, Alexander J Eckardt, Sarah Werling, Till Wehrmann, Jochem König, Ines Gockel
BACKGROUND AND AIMS: Pneumatic dilation (PD) is the most popular non-surgical treatment for achalasia. This study investigated predicting factors, including manometric subtypes for symptom recurrence in the long-term, in patients with achalasia treated with a single PD. PATIENTS AND METHODS: Between 1983 and 2013, a total of 107 patients were treated initially with a single PD and included in this longitudinal cohort study. Outcomes were correlated with demographics, symptoms (Eckardt Score), esophagographic and manometric features...
November 15, 2017: Journal of Gastroenterology and Hepatology
Yang Won Min, Youngha Kim, Geum-Youn Gwak, Seonhye Gu, Danbee Kang, Soo Jin Cho, Eliseo Guallar, Juhee Cho, Dong Hyun Sinn
BACKGROUNDS/AIMS: Nonalcoholic fatty liver disease (NAFLD), a hepatic manifestation of the metabolic syndrome, is associated with gastroesophageal reflux disease in cross-sectional studies, but a prospective association has not been evaluated. The current study aimed to determine whether NAFLD increases the risk of incident reflux esophagitis in a large cohort study. METHODS: We conducted a cohort study of 34,063 men and women without reflux esophagitis or other upper gastrointestinal disease at baseline who underwent health check-up examinations between January 2003 and December 2013...
November 12, 2017: Journal of Gastroenterology and Hepatology
Tsuyoshi Mishiro, Kentaro Oka, Yasutoshi Kuroki, Motomichi Takahashi, Kasumi Tatsumi, Tsukasa Saitoh, Hiroshi Tobita, Norihisa Ishimura, Shuichi Sato, Shunji Ishihara, Joji Sekine, Koichiro Wada, Yoshikazu Kinoshita
BACKGROUND AND AIM: Acid suppressive agents including proton pump inhibitors (PPIs) are used as first-line treatment for various acid-related gastrointestinal disorders. Although known to profoundly reduce gastric acid production, their influence on inhibition of acid secretion as part of the function of the gastrointestinal tract microbiome remains to be elucidated. The aim of the present study was to examine the effects of PPI usage on oral and gut microbiota in healthy volunteers. METHODS: Ten healthy adult volunteers receiving no medications were enrolled...
November 4, 2017: Journal of Gastroenterology and Hepatology
M D E Potter, S C Brienesse, M M Walker, A Boyle, N J Talley
INTRODUCTION: A gluten free diet (GFD), the mainstay of treatment for celiac disease, is being increasingly adopted by people without this condition. The long-term health effects of this diet, apart from its beneficial effect on enteropathy in celiac disease, are unclear. Concerns exist that the GFD may result in micronutrient deficiencies, increased exposure to toxins such as arsenic, and an increased cardiovascular risk. This systematic review addresses the effect of the GFD on several modifiable cardiovascular risk factors...
November 4, 2017: Journal of Gastroenterology and Hepatology
Morwan Bahi, Russell S Walmsley, Andrew R Gray, David Young, Catherine E Hobbs, Kristina Aluzaite, Michael Schultz
BACKGROUND AND AIM: New Zealand (NZ) has one of the highest rates of non-melanoma skin cancers (NMSC) in the world. Thiopurine use in Inflammatory Bowel Disease (IBD) patients has been shown to increase NMSC risk. This study aimed to investigate the possible increase of NMSC risk in thiopurine-treated IBD patients in NZ despite the high background rate. METHODS: IBD patients treated with thiopurines and healthy controls were recruited across two different latitude centers in NZ...
November 4, 2017: Journal of Gastroenterology and Hepatology
Jeung Hui Pyo, Sang Yun Ha, Sung Noh Hong, Dong Kyung Chang, Hee Jung Son, Kyoung-Mee Kim, Hyeseung Kim, Kyunga Kim, Jee Eun Kim, Yoon-Ho Choi, Young-Ho Kim
BACKGROUND AND AIM: Little is known about the risk factors associated with serrated polyps, because the early studies, which occurred before the new World Health Organization classification was introduced, included mixtures of serrated polyps. This study aimed to evaluate the risk factors associated with the presence of sessile serrated adenomas (SSAs) and traditional serrated adenomas (TSAs) using big data analytics. METHODS: Using a case-control design, we evaluated the risk factors associated with the presence of SSAs and TSAs...
October 31, 2017: Journal of Gastroenterology and Hepatology
Hiroki Tanaka, Noriko Kamata, Akihiro Yamada, Katsuya Endo, Toshimitsu Fujii, Takuya Yoshino, Takeshi Sugaya, Yoko Yokoyama, Shigeki Bamba, Junji Umeno, Yuka Yanai, Manabu Ishii, Takaaki Kawaguchi, Shinichiro Shinzaki, Yosuke Toya, Taku Kobayashi, Masanori Nojima, Toshifumi Hibi
BACKGROUND AND AIM: There are few studies on the long-term efficacy of adalimumab treatment for patients with Crohn's disease. We have conducted a large, multicenter, retrospective cohort study to evaluate the long-term retention rate and prognostic factors associated with the discontinuation of adalimumab treatment in patients with Crohn's disease. METHODS: Data were collected from all patients with Crohn's disease who had received at least one induction dose of 160 mg of adalimumab between October 2010 and December 2013 at 41 institutions...
October 31, 2017: Journal of Gastroenterology and Hepatology
Zheng-Kun Hou, Hong Mi, Feng-Bin Liu, Zhuo-Qun Chen, Xin-Lin Chen, Yu-Hang Wu, Xiao-Lu Che
BACKGROUND AND AIM: The Chinese version Quality of Life Questionnaire for Functional Digestive Disorders (Chin-FDDQL) is a useful health assessment instrument for functional dyspepsia. This study aims to identify its score interpretation for clinical practice. METHODS: Data of Chin-FDDQL from the FD patients (≥18yrs) between Nov. 2009 and Apr. 2013 were enrolled in the 1st and 14th day. After baseline and responsiveness analysis, the single score interpretation and percentile ranks were established...
October 26, 2017: Journal of Gastroenterology and Hepatology
Yang Yang, Jing Gao, Yu-Ting Tan, Hong-Lan Li, Jing Wang, Xiao Ma, Wei Zheng, Xiao-Ou Shu, Yong-Bing Xiang
BACKGROUND: Hepatitis B surface antigen (HBsAg) and viral load are both hallmarks of hepatitis B virus (HBV) infection and have potential to stratify liver cancer risk. METHODS: We carried out a nested case-control study including 211 liver cancer cases and 221 controls who were sero-positive for HBsAg within two population-based cohorts in Shanghai. Logistic regression was performed to estimate the odds ratios (ORs) and 95% confidence intervals (CIs). RESULTS: Risk of liver cancer was positively related to increasing levels of HBV DNA and HBsAg in dose-response manners...
October 24, 2017: Journal of Gastroenterology and Hepatology
Ho-Su Lee, Soo Bin Lee, Byoung Mok Kim, Myunghee Hong, Seulgi Jung, Jeonghoon Hong, Jiwon Baek, Buhm Han, Seak Hee Oh, Kyung Mo Kim, Sang Hyoung Park, Suk-Kyun Yang, Byong Duk Ye, Kyuyoung Song
BACKGROUND AND AIM: CDKN2A/B locus on 9p21 is reported to be associated with various diseases, including cancer, cardiovascular and inflammatory diseases. Significant down-regulation of CDKN2B-AS1 in inflamed colon tissue of IBD cases was reported in Europeans. This study aimed to confirm the suggestive association of CDKN2A/B with inflammatory bowel disease (IBD) identified in our recent genome-wide association study (GWAS). METHODS: We examined the association of CDKN2A/B locus with IBD in an additional sample of 574 IBD cases and 542 controls, totaling 4068 cases and 8074 controls...
October 24, 2017: Journal of Gastroenterology and Hepatology
Jun Arai, Kaku Goto, Anthony Stephanou, Yasushi Tanoue, Sayaka Ito, Ryosuke Muroyama, Yasuo Matsubara, Ryo Nakagawa, Sayuri Morimoto, Yoshimi Kaise, Lay Ahyoung Lim, Hitoshi Yoshida, Naoya Kato
BACKGROUND AND AIM: The multi-kinase inhibitor regorafenib (REG) was recently demonstrated to be effective in patients with sorafenib (SOR)-resistant hepatocellular carcinoma (HCC). Interestingly, SOR is known to enhance the accumulation of membrane-bound MHC class I polypeptide-related sequence A (mMICA) in HCC cells, and to block production of soluble MICA (sMICA), an immunological decoy. In addition, MICA is associated with HCC in patients with chronic hepatitis C. We have now compared the impact of REG and SOR on MICA in HCC cells, as well as the immunotherapeutic implications thereof...
October 21, 2017: Journal of Gastroenterology and Hepatology
Jung-Wook Kim, Chang Kyun Lee, Sang Youl Rhee, Chi Hyuck Oh, Jae-Jun Shim, Hyo Jong Kim
BACKGROUND AND AIMS: Data regarding healthcare costs and utilization for IBD at the population level are limited in Asia. We aimed to investigate the nationwide prevalence, and healthcare cost and utilization of IBD in Korea. METHODS: We tracked the IBD-attributable healthcare costs and utilization from 2010 to 2014 using the public dataset obtained from Korean National Health Insurance Service claims. We estimated the nationwide prevalence of IBD using population census data from Statistics Korea during the same period...
October 21, 2017: Journal of Gastroenterology and Hepatology
Yoon Suk Jung, Min-Jung Kwon, Dong Il Park, Chong Il Sohn, Jung Ho Park
BACKGROUND: Low activity of natural killer (NK) cells is known to be associated with higher risk of cancer, especially with poor prognosis and the presence of colorectal cancer (CRC). We investigated whether NK cells activity differs between subjects with and without colorectal neoplasia (CRN). METHODS: A cross-sectional study was performed on 1818 asymptomatic examinees aged ≥30 years who underwent NK cell activity test (which quantitates the amount of interferon-γ secreted into the plasma by NK cells) and a colonoscopy as part of a health check-up...
October 21, 2017: Journal of Gastroenterology and Hepatology
Fengze Sun, Huanhuan Sun, Xiangqiong Mo, Jianjun Tang, Yifeng Liao, Shuncong Wang, Yonghui Su, Haiqing Ma
BACKGROUND: Gastric cancer (GC) has the fifth highest incidence rate of all cancers and has a poor prognosis. However, no recent large-scale and long-term studies have evaluated the incidence and survival rates of individuals with GC. METHODS: In order to explore the change of GC incidence and survival rates by age, gender, race, socioeconomic status (SES), incidence data and survival status of patients with GC between 1984 and 2013 were abstracted from the Surveillance, Epidemiology and End Results (SEER) database...
October 19, 2017: Journal of Gastroenterology and Hepatology
Eiji Yamada, Yulia Namiki, Yuya Takano, Hikaru Takamine, Koji Inazumi, Hiroto Sasaki, Masayo Yamada, Satoshi Ito, Tomoyuki Iwasaki, Naoki Mantani, Taichi Minami, Uru Nezu Osada, Yasuo Terauchi, Atsushi Nakajima
BACKGROUND AND AIM: Changes in treatment protocols for patients with diabetes mellitus (DM) may influence the functions of the digestive tract. This study examined possible clinical factors associated with the symptoms of constipation in patients with DM. METHODS: This was a multicenter study. Participants were consecutive Japanese patients undergoing treatment for type 1 or type 2 DM. Constipation was evaluated using the gastrointestinal symptom rating scale. Diabetic neuropathy was evaluated by the presence or absence of peripheral neuropathy of the lower limbs...
October 19, 2017: Journal of Gastroenterology and Hepatology
Eun Hye Kim, Jun Chul Park, Sung Kwan Shin, Yong Chan Lee, Sang Kil Lee
BACKGROUND: Although propofol has been widely used for sedation during esophagogastroduodenoscopy (EGD), adverse events including hypoxia and hypotension may be a concern in the propofol-based sedation. We aimed to analyze whether administration of midazolam would improve safety and efficacy of propofol-based sedation in EGD. METHODS: One hundred twenty patients who were scheduled to undergo diagnostic EGD were randomly assigned to either midazolam plus propofol (MP) or propofol alone groups...
October 19, 2017: Journal of Gastroenterology and Hepatology
Yoon Suk Jung, Nam Hee Kim, Hyo-Joon Yang, Soo-Kyung Park, Jung Ho Park, Dong Il Park, Chong Il Sohn
BACKGROUND: Active smoking is well known to be a risk factor for colorectal neoplasia (CRN). However, it remains unclear whether passive smoking is also related to the risk of CRN. We investigated the effect of passive smoking on the risk of CRN in never, former, and current smokers. METHODS: A cross-sectional study was performed on asymptomatic examinees who underwent colonoscopy as part of a health check-up. RESULTS: Of 136,707 participants, 33,052 (24...
October 19, 2017: Journal of Gastroenterology and Hepatology
Hyosun Jang, Sunhoo Park, Janet Lee, Jae Kyung Myung, Won-Suk Jang, Sun-Joo Lee, Hyunwook Myung, Changsun Lee, Hyewon Kim, Seung-Sook Lee, Young-Woo Jin, Sehwan Shim
BACKGROUND AND AIM: Radiation-induced colitis is a common clinical problem associated with radiotherapy and accidental exposure to ionizing radiation. Goblet cells play a pivotal role in the intestinal barrier against pathogenic bacteria. Rebamipide, anti-gastric ulcer drug, has the effects to promote goblet cell proliferation. The aim of this study was to investigate whether radiation-induced colonic injury could be alleviated by rebamipide. METHODS: We orally administered rebamipide for 6 days to mice, which were subjected to 13 Gy abdominal irradiation, to evaluate the therapeutic effects of rebamipide against radiation-induced colitis...
October 19, 2017: Journal of Gastroenterology and Hepatology
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"