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Journal of Gastroenterology and Hepatology

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https://www.readbyqxmd.com/read/28806471/limited-uptake-of-ulcerative-colitis-treat-to-target-recommendations-in-real-world-practice
#1
Robert V Bryant, Samuel P Costello, Scott Schoeman, Dharshan Sathananthan, Emma Knight, Su-Yin Lau, Mark N Schoeman, Reme Mountifield, Derrick Tee, Simon P L Travis, Jane M Andrews
BACKGROUND & AIMS: A 'Treat to Target' (T2T) approach has been proposed for ulcerative colitis (UC), with a target of combined clinical and endoscopic remission. The aim of the study was evaluate the extent to which proposed targets are achieved in real-world care, along with clinician perceptions and potential challenges. METHODS: A multicentre, retrospective, cross-sectional review of patients with UC attending outpatient services in South Australia was conducted...
August 14, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28804920/thiopurines-prevented-surgical-recurrence-in-patients-with-crohn-s-disease-after-intestinal-resection-strategy-based-on-risk-stratification
#2
Jing Guo, Bai-Li Chen, Zhi-Hui Chen, Xia-Peng Luo, Yun Qiu, Sheng-Hong Zhang, Rui Feng, Yao He, Zhi-Rong Zeng, Xin-Ming Song, Shomron Ben-Horin, Ren Mao, Min-Hu Chen
BACKGROUND: Thiopurines (TPs) are effective in reducing risk of clinical and endoscopic recurrence in postoperative patients with Crohn's disease (CD). However, whether TPs could prevent surgical recurrence (SR) remains unknown. AIM: To explore whether TPs could prevent SR and identify risk factors associated with SR in postoperative CD patients. METHODS: This was a retrospective cohort study of 246 postoperative patients with CD. Cox proportional hazard model was used to identify risk factors for SR...
August 14, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28801987/predictors-of-long-term-outcomes-in-patients-with-acute-severe-colitis-a-northern-indian-cohort-study
#3
Saransh Jain, Saurabh Kedia, Tavpritesh Sethi, Sawan Bopanna, Dawesh Prakash Yadav, Sandeep Goyal, Rajesh Padhan, Pratap Mouli Venigalla, Peush Sahni, Nihar Ranjan Dash, Sujoy Pal, Govind Makharia, Simon P L Travis, Vineet Ahuja
BACKGROUND AND AIM: Knowledge of long-term outcomes following an index episode of acute severe colitis (ASC) can help informed decision-making at a time of acute exacerbation especially when colectomy is an option. We aimed to identify long-term outcomes and their predictors after a first episode of ASC in a large North Indian cohort. METHODS: Hospitalized patients satisfying Truelove and Witts' criteria under follow-up at a single centre from January 2003-December 2013 were included...
August 12, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28800384/exploring-conditions-for-redistribution-of-anti-tnfs-to-reduce-spillage-a-study-on-the-quality-of-anti-tnf-home-storage
#4
Marin J de Jong, Marieke J Pierik, Andy Peters, Mark Roemers, Veronique Hilhorst, Astrid van Tubergen
BACKGROUND AND AIM: Biologicals are potent drugs for immune mediated inflammatory diseases (IMIDs). After discontinuation or switch of therapy, many patients have unused biological injectors left. We aimed to evaluate potential redistribution of unused injectors to prevent spillage of these costly drugs by assessing 1) the quality of transport and home storage through the proportion of injectors stored within the recommended temperature range (2°C-8°C) and 2) acceptance of redistribution by patients...
August 11, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28786128/a-case-of-bile-duct-obstruction
#5
Teruyuki Kobayashi, Taro Aoki, Kimimasa Ikeda, Eiji Kurokawa
A 71-year-old female was admitted for the treatment of jaundice to our hospital. Her computed tomography revealed stenosis of the central bile duct accompanied with an irregular nodule shadow. Her bile cytodiagnosis and bile duct biopsy results were negative. Patient had a history of radiation treatment for a MALT lymphoma. It seemed that this radiation therapy might be the cause of bile duct stricture. But, we did not deny the presence of a malignancy because the bile duct stricture had caused jaundice and radiologic presence of a nodule shadow...
August 7, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28776769/a-rare-cause-of-hematemesis-initially-presenting-as-a-bleeding-gastric-dieulafoy-s-lesion
#6
Pieter J F de Jonge, Robert A de Man, Henk R van Buuren
No abstract text is available yet for this article.
August 3, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28771829/a-rare-vascular-tumour-following-treatment-for-hepatitis-c-with-direct-acting-antivirals
#7
K Britto, W Cheung, R Cameron, S K Roberts, W Kemp
No abstract text is available yet for this article.
August 3, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28770579/dietary-behaviors-in-relation-to-prevalence-of-irritable-bowel-syndrome-in-adolescent-girls
#8
Sayyed Saeid Khayyatzadeh, Seyyed Mohammad Reza Kazemi-Bajestani, Seyed Jamal Mirmousavi, Masoud Heshmati, Somaieh Khoshmohabbat, Gordon A Ferns, Majid Ghayour-Mobarhan
BACKGROUNDS AND AIMS: There is limited evidence regarding the relationship between dietary behaviors and irritable bowel syndrome (IBS). This study aimed to explore the association between diet-related practices and prevalence of IBS. METHODS: The study was conducted among 988 adolescent girls living in Iran. Dietary behaviors were pre-defined and assessed in nine domains using a pre-tested questionnaire. To investigate the association between diet-related practices and the presence of IBS, we used logistic regression analysis in crude and adjusted models...
August 2, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28770555/efficacy-of-liquid-nitrogen-cryotherapy-for-barrett-s-esophagus-after-endoscopic-resection-of-intramucosal-cancer-a-multicenter-study
#9
Arvind J Trindade, Douglas K Pleskow, Neil Sengupta, Shivangi Kothari, Sumant Inamdar, Joshua Berkowitz, Vivek Kaul
BACKGROUND AND AIM: Liquid nitrogen cryotherapy (LNC) allows increased depth of ablation compared to radiofrequency ablation (RFA) in Barrett's esophagus (BE). Expert centers may use LNC over RFA to ablate Barrett's esophagus after endoscopic resection of intramucosal cancer (IMCA). The aim of our study was to: 1) evaluate the safety and efficacy of LNC ablation in patients with BE and IMCA and 2) to evaluate the progression to invasive disease despite therapy. METHODS: This was a multicenter, retrospective study of consecutive patients with BE who received LNC following endoscopic mucosal resection (EMR) of IMCA...
August 2, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28768372/gastric-inflammatory-fibroid-polyp-that-was-resected-after-a-10-year-follow-up
#10
Kyosuke Tanaka, Takashi Sakuno, Reiko Yamada, Yasuhiko Hamada, Masaki Katsurahara, Noriyuki Horiki, Yoshiyuki Takei
No abstract text is available yet for this article.
August 2, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28768371/minimal-hepatic-encephalopathy-identifies-patients-at-risk-of-faster-cirrhosis-progression
#11
Javier Ampuero, Carmina Montoliú, Macarena Simón-Talero, Virginia Aguilera, Raquel Millán, Celina Márquez, Rodrigo Jover, María Carmen Rico, Carmen Sendra, Miguel Ángel Serra, Manuel Romero-Gómez
BACKGROUND &AIM: Minimal hepatic encephalopathy (MHE) predicts poor prognosis and could reflect an advanced liver disease. We aimed to assess whether MHE could be a surrogate marker of a further liver disease. METHODS: Prospective multicenter study including 320 cirrhotic patients, followed for up to 5 years, which were classified at baseline in: compensated cirrhosis without (stage 1) and with varices (stage 2), one decompensating event (stage 3), any second decompensating event (stage 4)...
August 2, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28768370/efficacy-and-safety-of-nortriptyline-in-functional-dyspepsia-in-asians-a-randomized-double-blind-placebo-controlled-trial
#12
Uayporn Kaosombatwattana, Supot Pongprasobchai, Julajak Limsrivilai, Monthira Maneerattanaporn, Somchai Leelakusolvong, Tawesak Tanwandee
AIMS: Current treatments of functional dyspepsia (FD) are unsatisfied. Tricyclic antidepressants alter visceral hypersensitivity and brain-gut interaction. We assessed the efficacy and safety of nortriptyline in patients with FD. METHODS: Patients diagnosed functional dyspepsia according to Rome III criteria who failed to respond to proton pump inhibitor and prokinetic treatment were randomly assigned to either once daily 10-mg nortriptyline or placebo. The primary endpoint was the rate of responders defined as a > 50% reduction in dyspepsia symptom score(DSS) after 8 weeks of treatment...
August 2, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28768367/mirizzi-syndrome-masquerading-as-primary-cholangiocarcinoma
#13
Adam B Gluskin, Srinadh Komanduri
A 72-year-old man presented with neutropenic fever secondary to cholangitis and was discovered to have Mirizzi Syndrome on ERCP and cholangioscopy which initially appeared to be cholangiocarcinoma.
August 2, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28762541/real-world-effectiveness-and-safety-of-paritaprevir-ritonavir-ombitasvir-and-dasabuvir-with-or-without-ribavirin-for-patients-with-chronic-hepatitis-c-virus-genotype-1b-infection-in-taiwan
#14
Chen-Hua Liu, Chun-Jen Liu, Tung-Hung Su, Hung-Chih Yang, Chun-Ming Hong, Tai-Chung Tseng, Pei-Jer Chen, Ding-Shinn Chen, Jia-Horng Kao
BACKGROUND AND AIM: The real-world effectiveness and safety of paritaprevir/ritonavir, ombitasvir, and dasabuvir (PrOD) remain limited for East Asian hepatitis C virus genotype 1b (HCV-1b) patients. We aimed to evaluate the anti-viral responses of PrOD-based regimens for HCV-1b patients in Taiwan. METHODS: We performed a retrospective analysis of 103 HCV-1b patients receiving PrOD with or without ribavirin (RBV) for 12 weeks. Data were analyzed to assess the on-treatment and off-therapy HCV viral load, and on-treatment adverse events (AEs)...
August 1, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28762251/h-pylori-management-in-asean-the-bangkok-consensus-report
#15
REVIEW
Varocha Mahachai, Ratha-Korn Vilaichone, Rapat Pittayanon, Jarin Rojborwonwitaya, Somchai Leelakusolvong, Monthira Maneerattanaporn, Peranart Chotivitayatarakorn, Sombat Treeprasertsuk, Chomsri Kositchaiwat, Pises Pisespongsa, Pisaln Mairiang, Aziz Rani, Alex Leow, Swe Mon Mya, Yi-Chia Lee, Sengdao Vannarath, Bouachanh Rasachak, Oung Chakravuth, Moe Myint Aung, Tiing-Leong Ang, Jose D Sollano, Duc Quach Trong, Inchaya Sansak, Olarn Wiwattanachang, Piyathida Harnsomburana, Ari Fahrial Syam, Yoshio Yamaoka, Kwong-Ming Fock, Khean-Lee Goh, Kentaro Sugano, David Graham
Helicobacter pylori (H. pylori) infection remains to be the major cause of important upper gastrointestinal diseases such as chronic gastritis, peptic ulcer, gastric adenocarcinoma and mucosa-associated lymphoid tissue (MALT) lymphoma. H. pylori management in ASEAN: the Bangkok consensus report gathered key opinion leaders for the region to review and evaluate clinical aspects of H. pylori infection and to develop consensus statements, rationales and grades of recommendation for the management of H. pylori infection in clinical practice in ASEAN countries...
July 31, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28759709/reconstruction-method-as-an-independent-risk-factor-for-postoperative-bone-mineral-density-loss-in-gastric-cancer
#16
Taisuke Imamura, Shuhei Komatsu, Daisuke Ichikawa, Toshiyuki Kosuga, Takeshi Kubota, Kazuma Okamoto, Hirotaka Konishi, Atsushi Shiozaki, Hitoshi Fujiwara, Eigo Otsuji
BACKGROUND AND AIM: No study has compared the incidence of postoperative bone metabolic disorders between Billroth-I (B-I) and Roux-en-Y (R-Y) reconstructions after distal gastrectomy (DG) for gastric cancer (GC). In this study, we wished to examine the impact of reconstruction method on postoperative bone mineral density (BMD) loss. METHOD: We investigated a total of 148 consecutive patients who underwent DG with B-I or R-Y reconstruction for stage I GC between 2008 and 2012...
July 31, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28753738/the-modification-of-splenic-stiffness-on-acoustic-radiation-force-impulse-parallels-the-variation-of-portal-pressure-induced-by-transjugular-intrahepatic-portosystemic-shunt
#17
Adriano De Santis, Silvia Nardelli, Chiara Bassanelli, Marinella Lupo, Claudia Iegri, Carmela Anna Di Ciesco, Mariana Forlino, Alessio Farcomeni, Oliviero Riggio
BACKGROUND: Spleen and liver stiffness measured by Acoustic radiation force impulse (ARFI) imaging has been showed to be useful in identifying patients with portal hypertension. AIM: to establish if the modification of portal pressure induced by a TIPS parallels the modification of spleen or liver stiffness measured by ARFI in order to understand if ARFI may be used to monitor the modification of portal pressure in patients with cirrhosis. PATIENTS AND METHODS: 38 patients with severe portal hypertension underwent liver stiffness (LS) and spleen stiffness (SS) before TIPS and one week after TIPS...
July 28, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28748532/rdxa-frxa-and-efflux-pump-in-metronidazole-resistant-helicobacter-pylori-their-relation-to-clinical-outcomes
#18
Sun Min, Nayoung Kim, Yong Hwan Kwon, Ryoung Hee, Jung Mogg Kim, Jong Youn, Yeon Suk Lee, Dong Ho Lee
BACKGROUND AND AIM: rdxA and frxA mutations and enhancement of efflux pump have been suggested as the cause of metronidazole resistance in Helicobacter pylori. This study was performed to investigate the resistance mechanisms related to clinical eradication outcome, and to examine direct involvement of hefA in metronidazole-resistant isolates with intact rdxA and frxA. METHODS: A total of 53 H. pylori-positive patients who were treated with metronidazole-containing sequential or quadruple therapy from 2011 to 2015 were enrolled...
July 27, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28736848/the-risk-of-colorectal-neoplasia-can-be-different-according-to-the-types-of-family-members-affected-by-colorectal-cancer
#19
Nam Hee Kim, Hyo-Joon Yang, Soo-Kyung Park, Jung Ho Park, Dong Il Park, Chong Il Sohn, Yoon Suk Jung
BACKGROUND: A family history of colorectal cancer (CRC) is an important risk factor for CRC, but more detailed data are needed to prepare effective screening guidelines. We aimed to evaluate the risk of colorectal neoplasia (CRN) among individuals with different relatives affected by CRC (the first-degree relatives [FDRs] or the second-degree relatives [SDRs] or the first cousins) and to assess the effects of family histories according to age groups (30-39, 40-49, and ≥50 years). METHODS: A cross-sectional study was performed on 98,562 asymptomatic examinees aged ≥ 30 years who underwent colonoscopy as part of a health check-up...
July 24, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28730699/elevated-cardiac-troponin-t-in-cirrhotic-patients-with-emergency-care-admissions-is-associated-with-mortality
#20
Mayada Elnegouly, Katrin Umgelter, Wajima Safi, Alexander Hapfelmeier, Roland M Schmid, Andreas Umgelter
BACKGROUND & AIMS: Mortality of cirrhotic patients after emergency care admission is high and prognostic factors can help in prioritizing patients. The aim of our study was to assess the association between levels of cardiac Troponin T (cTnT) and one-year mortality in patients with liver cirrhosis without known cardiac disease, who were admitted to the emergency department (ED). METHODS: All patients with cirrhosis presented to the ED from October 2009 until August 2015 who had an initial cTnT value measured with the first lab-panel were retrospectively analyzed with a follow-up of 365 days...
July 20, 2017: Journal of Gastroenterology and Hepatology
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