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Journal of Gastroenterology and Hepatology

Harun-Or Rashid, Hyun-Kyoung Kim, Raghupatil Junjappa, Hyung-Ryong Kim, Han-Jung Chae
Compromised protein folding capacity in the endoplasmic reticulum (ER) leads to a protein traffic jam that produces a toxic environment called ER stress. However, the ER smartly handles such a critical situation by activating a cascade of proteins responsible for sensing and responding to the noxious stimuli of accumulated proteins. The ER protein load is higher in secretory cells, such as liver hepatocytes, which are thus prone to stress-mediated toxicity and various diseases, including alcohol-induced liver injury, fatty liver disease, and viral hepatitis...
October 23, 2016: Journal of Gastroenterology and Hepatology
Jem Ma Ahn, Chang Ha Kim, Soon Ho Um, Kyung Mee Kim, Tae Hyung Kim, Sun Young Yim, Hyuk Soon Choi, Eun Sun Kim, Bora Keum, Yeon Seok Seo, Hyung Joon Yim, Yoon Tae Jeen, Hong Sik Lee, Hoon Jai Chun, Chang Duck Kim, Ho Sang Ryu
BACKGROUND AND AIM: In a recent study, microsatellite variations (GCA tandem repeats) in the promoter region of the (kidney-type) glutaminase gene were associated with the development of hepatic encephalopathy (HE) in Spanish patients with cirrhosis. The objective of this study was to validate the relation between microsatellite variations in the glutaminase promoter region and the development of overt HE in Korean patients with liver cirrhosis. METHODS: We performed a prospective cohort study of 154 cirrhotic patients who underwent a glutaminase microsatellite study without previous overt HE history at baseline...
October 17, 2016: Journal of Gastroenterology and Hepatology
Mohammad Minakari, Shervin Badihian, Pooyan Jalalpour, Vahid Sebghatollahi
BACKGROUND AND AIM: Upper gastrointestinal bleeding (UGIB) is a threatening condition leading to urgent hospitalization. This study aims to investigate etiology and outcome in UGIB patients in Iran. METHODS: Medical records of GIB patients admitted to Alzahra referral hospital (in Isfahan) during 2010-2015 were retrospectively reviewed for demographic data, comorbidities, history of smoking and taking non-steroidal anti-inflammatory drugs (NSAIDs), presenting symptoms, endoscopic findings, therapeutic endoscopy, blood products' infusion, surgical intervention and mortality...
October 17, 2016: Journal of Gastroenterology and Hepatology
Yundong Qu, Ying Guo, Tao Li, Qian Ye, Chao Sun, Lei Wang, Baohua Yang
BACKGROUND AND AIM: To assess the efficacy and safety of sofosbuvir-based interferon-free therapies in liver transplantation recipients with hepatitis C virus infection recurrence. METHODS: A systematic literature search was conducted in PubMed, EMBASE, Web of Science, and CENTRAL on the Cochrane Library without time or language limitation. The search strategy used was "sofosbuvir AND transplantation". Sustained virologic response at 12 weeks after the end of treatment (SVR12) rate, incidence of serious adverse events (SAEs) and/or adverse events (AEs), discontinuation rate with 95% confidence intervals (CI) were pooled with random-effects model...
October 17, 2016: Journal of Gastroenterology and Hepatology
Arnaud Del Bello, Marie Danjoux, Nicolas Congy-Jolivet, Laurence Lavayssière, Laure Esposito, Fabrice Muscari, Nassim Kamar
BACKGROUND AND AIM: Acute antibody-mediated rejection (aAMR) is an unusual complication after orthotopic ABO-compatible liver transplantation. To date, the clinical and histological long-term outcomes after aAMR are not well known. METHOD: Herein, we describe 9 cases of aAMR that occurred in our liver-transplant center between 2008 and 2016, with an initial and reevaluation liver biopsy available for reexamination. RESULTS: Two patients presented with aAMR at 10...
October 14, 2016: Journal of Gastroenterology and Hepatology
Jae Hee Cheon
Remarkable advances have been made in the treatment of inflammatory bowel disease (IBD) since the introduction of anti-tumor necrosis factor (TNF)-α agents, especially for patients who are refractory to or cannot tolerate conventional therapies. Currently, infliximab, adalimumab, and golimumab are available in the East Asian medical market, and these agents have been shown to be effective for inducing and maintaining long-term remission of IBD. Despite their clinical benefits, anti-TNF therapy can also lead to increased vulnerability to infections, development of autoimmune diseases and malignancy, and decreased immunogenicity of vaccinations...
October 10, 2016: Journal of Gastroenterology and Hepatology
Robert N Lopez, Steven T Leach, Daniel A Lemberg, Gilles Duvoisin, Richard B Gearry, Andrew S Day
Over the last two decades knowledge on faecal biomarkers has substantially increased. Nowadays these non-invasive markers of inflammation have significant clinical utility in the management of inflammatory bowel disease (IBD). Their use informs the decision to perform endoscopy before diagnosis is made right through to influencing therapeutic choices and the need for interval endoscopic assessment. In this review, the roles of two S100 proteins, calprotectin and S100A12 are described along with that of lactoferrin, in the context of IBD...
October 10, 2016: Journal of Gastroenterology and Hepatology
Jian Zeng, Lin Lv, Zhe-Chuan Mei
BACKGROUND AND AIM: Budesonide is a second-generation steroid with prominent topical effects and minimal systemic activity for patients with ulcerative colitis (UC). We perform a systematic review and meta-analysis of randomized placebo-controlled trials to assess the efficacy and safety of budesonide foam in mild to moderate distal UC. METHODS: Comprehensive searches were performed to identify all eligible studies. Outcome measures were clinical remission, endoscopic improvement, elimination of rectal bleeding and adverse events...
October 3, 2016: Journal of Gastroenterology and Hepatology
Po-Hong Liu, Chia-Yang Hsu, Cheng-Yuan Hsia, Yun-Hsuan Lee, Yi-You Chiou, Yi-Hsiang Huang, Fa-Yauh Lee, Han-Chieh Lin, Ming-Chih Hou, Teh-Ia Huo
BACKGROUND: The severity of liver dysfunction in hepatocellular carcinoma (HCC) is often estimated with Child-Turcotte-Pugh (CTP) classification or model for end-stage liver disease (MELD) score. We aim to investigate the performance of albumin-bilirubin (ALBI) and platelet-albumin-bilirubin (PALBI) grade, which are recently reported to be simple and objective measurements for liver reserve in HCC. METHODS: Between 2002 and 2014, consecutive 3,182 HCC patients were enrolled to follow up their survival...
October 3, 2016: Journal of Gastroenterology and Hepatology
Pengxiang Yang, Yue Yang, Weiwei An, Jianyu Xu, Gan Zhang, Jing Jie, Qingyuan Zhang
BACKGROUND AND AIM: LincRNAs have critical roles in elevating efficacy of anticancer therapy and tumor progression. Recent studies show that long intergenic noncoding RNA-ROR (lincRNA-ROR) is aberrantly expressed in several types of cancer, including colorectal cancer (CRC). Radiotherapy is considered as a standard preoperative treatment. However, a considerable number of CRCs are resistant to radiotherapy. In this study, we evaluated the role of lincRNA-ROR in radiotherapy for CRC and detected the underlying molecular mechanism...
October 3, 2016: Journal of Gastroenterology and Hepatology
Hui Zhao, Chuang Chen, Shen Gu, Xiaopeng Yan, Wenjun Jia, Liang Mao, Yudong Qiu
BACKGROUND AND AIM: The superiority of anatomical resection (AR) in patients with hepatocellular carcinoma compared with non-anatomical resection (NAR) remains controversial. We aimed to investigate the prognostic outcomes of AR and NAR for solitary HCC patients without macroscopic vascular invasion, using a propensity score matching (PSM) analysis. METHODS: A total of 305 consecutive HCC patients without macroscopic vascular invasion underwent curative hepatectomy were included in our study...
September 26, 2016: Journal of Gastroenterology and Hepatology
Sung Ill Jang, Jin-Hyeok Hwang, Kwang-Hun Lee, Jeong-Sik Yu, Hee Wook Kim, Chang Jin Yoon, Yoon Suk Lee, Kyu Hyun Paik, Sang Hyub Lee, Dong Ki Lee
BACKGROUND AND AIM: Palliative endoscopic or percutaneous biliary drainage is used for unresectable advanced hilar cancer (HC). The best option for drainage in Bismuth type III or IV HC has not been established. The aims of this study are to identify factors predictive of endoscopic stenting failure and evaluate the effectiveness of rescue percutaneous stenting in patients with advanced HC. METHODS: Data from 110 patients with inoperable advanced HC were retrospectively reviewed...
September 25, 2016: Journal of Gastroenterology and Hepatology
Shinwa Tanaka, Takashi Toyonaga, Yoshinori Morita, Tsukasa Ishida, Namiko Hoshi, Kevin L Grimes, Yoshiko Ohara, Tetsuya Yoshizaki, Fumiaki Kawara, Eiji Umegaki, Takeshi Azuma
BACKGROUND AND AIM: Currently, endoscopic submucosal dissection (ESD) is a widely accepted standard treatment for early gastric cancer, but one challenging aspect of ESD is hemostasis. We developed a new hemostatic forceps (FD-Y0007) with the aim of achieving more effective hemostasis and investigated the hemostatic ability of the FD-Y0007 during gastric ESD in humans. METHODS: This study was a prospective randomized controlled trial, which was conducted at a cancer referral center...
September 20, 2016: Journal of Gastroenterology and Hepatology
Silje Thorsvik, Jan Kristian Damås, Atle van Beelen Granlund, Trude Helen Flo, Kåre Bergh, Ann Elisabet Østvik, Arne Kristian Sandvik
BACKGROUND AND AIM: Accurate, non-invasive biomarkers are needed to diagnose and monitor inflammatory bowel disease (IBD). Neutrophil Gelatinase Associated Lipocalin (NGAL), also known as Lipocalin 2, is expressed in inflamed colonic epithelium and neutrophilic granulocytes. This study explores its properties as a biomarker in feces and plasma and, for the first time, compares fecal NGAL systematically with the existing fecal biomarker calprotectin. METHODS: NGAL was measured in feces from 73 patients with IBD, 21 patients with infectious enterocolitis, 21 patients with irritable bowel syndrome (IBS) and 23 healthy subjects using ELISA...
September 18, 2016: Journal of Gastroenterology and Hepatology
Chung-Feng Huang, Ching-I Huang, Ming-Lun Yeh, Chen Hou, Nai-Jen Hou, Ming-Yen Hsieh, Jee-Fu Huang, Shinn-Cherng Chen, Zu-Yau Lin, Chia-Yen Dai, Wan-Long Chuang, Ming-Lung Yu
BACKGROUND/AIMS: The erythropoiesis in hepatitis C virus infection is unclear. We aimed to evaluate the erythropoietic components in chronic hepatitis C (CHC) patients. METHODS: The red blood cell (RBC) components, serum erythropoietin levels as well as their relationship to clinical characteristics were evaluated between 124 age-, sex-matched healthy controls and 248 histology-proven CHC patients. RESULTS: CHC patients had significantly higher serum levels of erythropoietin (EPO) (1...
September 16, 2016: Journal of Gastroenterology and Hepatology
Sung Woo Jung, Seung Young Kim, Jung Wan Choe, Jong Jin Hyun, Yong Kul Jung, Ja Seol Koo, Hyung Joon Yim, Sang Woo Lee
BACKGROUND AND AIMS: Endoscopic resection is commonly used to remove gastric neoplasms. However, effective dosing or scheduling of proton pump inhibitors for the prevention of delayed bleeding after endoscopic resection remains unclear. PATIENTS AND METHODS: One hundred sixty-six patients with gastric adenoma or early gastric cancer were enrolled. After an endoscopic procedure, each subject was randomly assigned to 40 mg every 24 h (standard dose group) or 40 mg every 12 h (double dose group) of intravenous pantoprazole for 48 h...
September 16, 2016: Journal of Gastroenterology and Hepatology
Ho-Su Lee, Jaewon Choe, Seon-Ok Kim, Sun-Ho Lee, Hyo Jeong Lee, Hyungil Seo, Gwang-Un Kim, Myeongsook Seo, Eun Mi Song, Sung Wook Hwang, Sang Hyoung Park, Dong-Hoon Yang, Kyung-Jo Kim, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Yong Sik Yoon, Chang Sik Yu, Jin-Ho Kim, Suk-Kyun Yang
BACKGROUND AND AIM: Limited data are available regarding mortality from inflammatory bowel disease in non-Caucasian populations. Herein, we evaluated overall and cause-specific mortality in a hospital-based cohort of Korean inflammatory bowel disease patients. METHODS: We determined mortality in 2,414 Crohn's disease patients and 2,798 ulcerative colitis patients diagnosed between 1977 and 2013. Standardized mortality ratios were calculated in several demographic and phenotypic subgroups...
September 16, 2016: Journal of Gastroenterology and Hepatology
Shigeru Horiguchi, Hironari Kato, Hidenori Shiraha, Koichiro Tsutsumi, Naoki Yamamoto, Kazuyuki Matsumoto, Takeshi Tomoda, Daisuke Uchida, Yutaka Akimoto, Syou Mizukawa, Takehiro Tanaka, Koichi Ichimura, Akinobu Takaki, Takahito Yagi, Hiroyuki Okada
BACKGROUND AND AIM: Pathological grading is important in defining the therapeutic strategy in pancreatic neuroendocrine neoplasm (PNEN), but is difficult for unresectable cases. Endoscopic ultrasound (EUS)-guided fine needle aspiration (FNA) is useful in the diagnosis of PNEN, but its usefulness for pathological grading is not well established. No studies have examined the diagnostic ability of dynamic computed tomography (CT) for pathological grading of PNEN. We investigated the usefulness of EUS-FNA and dynamic CT in the diagnosis and pathological grading of PNEN...
September 16, 2016: Journal of Gastroenterology and Hepatology
Sandeep Satsangi, Manu Mehta, Ajay Duseja, Sunil Taneja, Radha K Dhiman, Yogesh Chawla
INTRODUCTION: Sofosbuvir (SOF) was the first directly acting antiviral (DAA) made available for chronic hepatitis C (CHC) in India. We describe our 'real life' experience of using SOF with ribavirin (RBV) with or without pegylated interferon (PegIFN) in predominant genotype 3 patients with CHC. METHODOLOGY: 158 patients [Males 99 (62.6%), mean age 40.3 ± 12.8 years) with CHC treated with dual therapy (SOF + RBV) for 24 weeks or triple therapy (PegIFN + SOF + RBV) for 12 weeks were included prospectively...
September 14, 2016: Journal of Gastroenterology and Hepatology
Basile Njei, Thomas R McCarty, Loren Laine
BACKGROUND AND AIM: Early transjugular intrahepatic portosystemic shunt (TIPS) used as preventive therapy prior to recurrent bleeding has been recommended in patients presenting with acute esophageal variceal bleeding (EVB) who are at high risk of further bleeding and death. We investigated the impact of early TIPS on outcomes of U.S. patients hospitalized with EVB from 2000 to 2010. METHODS: The Nationwide Inpatient Sample database was queried to identify patients with EVB and decompensated cirrhosis (because early TIPS is recommended only in high-risk patients)...
September 14, 2016: Journal of Gastroenterology and Hepatology
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