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Journal of Gastroenterology and Hepatology

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https://www.readbyqxmd.com/read/28921677/clinical-profile-of-hepatitis-c-virus-infection-in-a-developing-country-india
#1
Ramit Mahajan, Vandana Midha, Omesh Goyal, Varun Mehta, Vikram Narang, Kirandeep Kaur, Arshdeep Singh, Dharmatma Singh, Rishu Bhanot, Ajit Sood
BACKGROUND: The epidemiology and clinical profile of hepatitis C virus (HCV) varies worldwide and data from developing countries is sparse. AIMS: To study the clinical profile of HCV infection in a developing country in South East Asia (India). METHODS: This observational study assessed patient demographics, viral characteristics, risk factors for virus acquisition and disease characteristics in HCV patients diagnosed between January 2004 and December 2015...
September 18, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28921629/validation-of-prognostic-scores-to-predict-short-term-mortality-in-patients-with-acute-on-chronic-liver-failure
#2
Do Seon Song, Tae Yeob Kim, Dong Joon Kim, Hee Yeon Kim, Dong Hyun Sinn, Eileen L Yoon, Chang Wook Kim, Young Kul Jung, Ki Tae Suk, Sang Soo Lee, Chang Hyeong Lee, Tae Hun Kim, Won Hyeok Choe, Hyung Joon Yim, Sung Eun Kim, Soon Koo Baik, Jae Young Jang, Hyoung Su Kim, Sang Gyune Kim, Jin Mo Yang, Joo Hyun Sohn, Eun Hee Choi, Hyun Chin Cho, Soung Won Jeong, Moon Young Kim
BACKGROUND AND AIM: The aim of this study was to validate the Chronic Liver Failure-Sequential Organ Failure Assessment score (CLIF-SOFAs), CLIF consortium organ failure score (CLIF-C OFs), CLIF-C acute-on-chronic liver failure score (CLIF-C ACLFs), and CLIF-C acute decompensation score (CLIF-C ADs) in Korean chronic liver disease patients with acute deterioration. METHODS: ACLF was defined by either the Asian Pacific Association for the Study of the Liver ACLF Research Consortium (AARC) or CLIF-C criteria...
September 16, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28914957/hepatitis-b-virus-core-related-antigen-levels-predict-progression-to-liver-cirrhosis-in-hepatitis-b-carriers
#3
Toshifumi Tada, Takashi Kumada, Hidenori Toyoda, Natsuko Kobayashi, Tomoyuki Akita, Junko Tanaka
BACKGROUND AND AIM: Several hepatitis B virus (HBV) markers have been identified as risk factors for progression to liver cirrhosis in patients with chronic HBV infection. We clarified the predictive impact of HBV markers on progression to cirrhosis in HBV carriers. METHODS: A total of 529 hepatitis B e antigen seroconverters with FIB-4 index ≤3.6 not on nucleos(t)ide analogue therapy were included. We performed univariate and multivariate analysis of associations between HBV markers and progression to cirrhosis...
September 15, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28910851/efficacy-of-hemostatic-powder-in-preventing-bleeding-after-gastric-endoscopic-submucosal-dissection-in-high-risk-patients
#4
Kyu Yeon Hahn, Jun Chul Park, Yong Kang Lee, Sung Kwan Shin, Sang Kil Lee, Yong Chan Lee
BACKGROUND AND STUDY AIM: The prevention of post-endoscopic submucosal dissection (ESD) bleeding in high-risk patients is an important problem. This study evaluated the efficacy of polysaccharide hemostatic powder in preventing post-ESD bleeding in high-risk patients. METHODS: Patients at high risk for post-ESD bleeding were prospectively enrolled between December 2015 and July 2016. A high risk of post-ESD bleeding was considered if the patients were taking antithrombotic agents or had undergone a large resection (specimen size ≥ 40mm)...
September 14, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28910501/serum-cystatin-c-level-is-an-excellent-predictor-of-mortality-in-patients-with-cirrhotic-ascites
#5
Yeon Seok Seo, Soo Young Park, Moon Young Kim, Sang Gyune Kim, Jun Yong Park, Hyung Joon Yim, Byoung Kuk Jang, Seung Ha Park, Ji Hoon Kim, Ki Tae Suk, Jin Dong Kim, Tae Yeob Kim, Eun Young Cho, Jun Sung Lee, Soung Won Jung, Jae Young Jang, Hyonggin An, Won Young Tak, Soon Koo Baik, Jae Seok Hwang, Young Seok Kim, Joo Hyun Sohn, Soon Ho Um
BACKGROUND/AIMS: Although serum cystatin C level is considered a more accurate marker of renal function in patients with liver cirrhosis, its prognostic efficacy remains uncertain. This study aimed to evaluate the prognostic efficacy of serum cystatin C level in patients with cirrhotic ascites. METHODS: Patients with cirrhotic ascites from 15 hospitals were prospectively enrolled between September 2009 and March 2013. Cox regression analyses were performed to identify independent predictive factors of mortality and development of type 1 hepatorenal syndrome (HRS-1)...
September 14, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28902972/covered-duodenal-self-expandable-metal-stents-prolong-biliary-stent-patency-in-double-stenting-the-largest-series-of-bilioduodenal-obstruction
#6
Yasuki Hori, Itaru Naitoh, Kazuki Hayashi, Hiromu Kondo, Michihiro Yoshida, Shuya Shimizu, Atsuyuki Hirano, Fumihiro Okumura, Tomoaki Ando, Naruomi Jinno, Hiroki Takada, Shozo Togawa, Takashi Joh
BACKGROUND: Endoscopic biliary and duodenal stenting (DS; double stenting) is widely accepted as a palliation therapy for malignant bilioduodenal obstruction. The aim of the current study was to investigate the patency and adverse events of duodenal and biliary stents in patients with DS. METHODS: Patients who underwent DS from April 2004 to March 2017 were analyzed retrospectively with regard to clinical outcomes and predictive factors of recurrent biliary and duodenal obstruction (recurrent biliary obstruction [RBO] and recurrent duodenal obstruction [RDO])...
September 13, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28901578/irritable-bowel-syndrome-in-asia-pathogenesis-natural-history-epidemiology-and-management
#7
REVIEW
Kok-Ann Gwee, Uday Chand Ghoshal, Minhu Chen
Historically, the epidemiology of gastrointestinal diseases in Asia was different from that in Western countries. Early studies suggested a low prevalence of irritable bowel syndrome (IBS) in Asia. As the diagnosis of IBS is symptom-based, and as symptom perception, expression and interpretation, are influenced by sociocultural perspectives including language, the presentation of IBS is expected to vary in different communities. Furthermore, the pathogenesis is multifactorial with psychosocial (stress, illness, behavior, diet) and biological (infection, gut microbiota, immune activation) variables interacting, and so we can anticipate that the development of IBS will vary in different environments...
September 13, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28898473/influence-of-prucalopride-on-esophageal-secondary-peristalsis-in-reflux-patients-with-ineffective-motility
#8
Wei-Yi Lei, Jui-Sheng Hung, Tso-Tsai Liu, Chih-Hsun Yi, Chien-Lin Chen
BACKGROUNDS/AIM: Ineffective esophageal motility (IEM) is associated with gastroesophageal reflux disease (GERD). Secondary peristalsis contributes to esophageal clearance. Prucalopride promotes secondary peristalsis by stimulating 5-hydroxytrypatamine 4 receptors in the esophagus. We aimed to determine whether prucalopride would augment secondary peristalsis in GERD patients with IEM. METHODS: After a baseline recording of primary peristalsis, secondary peristalsis was stimulated by slow and rapid mid-esophageal injections of air in 15 patients with IEM...
September 12, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28892839/impact-of-feedback-on-adenoma-detection-rates-outcomes-of-quality-improvement-program
#9
Suryakanth R Gurudu, Erika S Boroff, Michael D Crowell, Mary Atia, Sarah B Umar, Jonathan A Leighton, Douglas O Faigel, Francisco C Ramirez
BACKGROUND AND AIMS: Feedback has been shown to improve performance in colonoscopy including adenoma detection rate (ADR). The frequency at which feedback should be given is unknown. As part of a quality improvement program we sought to measure the outcome of providing quarterly and monthly feedback on colonoscopy quality measures. METHODS: All screening colonoscopies performed at endoscopy unit at Mayo Clinic Arizona by gastroenterologists between October 2010 and December 2012 were reviewed...
September 11, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28884481/estrogen-receptor-%C3%AE-selective-agonist-ameliorates-liver-cirrhosis-in-rats-by-inhibiting-the-activation-and-proliferation-of-hepatic-stellate-cells
#10
Bin Zhang, Cheng-Gang Zhang, Lin-Hua Ji, Gang Zhao, Zhi-Yong Wu
AIM: To explore the roles of ER subtypes and corresponding agonists/antagonists on the development of cirrhosis and activation and proliferation of HSCs. METHODS: Carbon tetrachloride (CCl4 ) -induced cirrhotic ovariectomized rats were administered non-selective ER agonist (β-estradiol, E2), ER selective agonists (ERα agonist, PPT; ERβ agonist, DPN; GPER agonist, G1) or E2 + ER selective antagonists (ERα antagonist, MPP; ERβ antagonist, PHTPP; GPER antagonist, G15) for 12 weeks...
September 7, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28873259/increased-enteric-glial-cells-in-proximal-margin-of-resection-is-associated-with-postoperative-recurrence-of-crohn-s-disease
#11
Yi Li, Yuanyuan Ge, Weiming Zhu, Jianfeng Gong, Lei Cao, Zhen Guo, Lili Gu, Jieshou Li
BACKGROUND AND AIM: The enteric nervous system can amplify or modulate intestinal inflammation through secretion of neuropeptides, and enteric glial cells has been implicated in the pathophysiology of Crohn's disease. The goal of the study was to search for an association between the density of neurons, neuropeptides, as well as enteric glial cells and postoperative recurrence. METHODS: The ileal proximal uninflamed section from ileocolonic sample was studied using immunohistochemistry with antibodies directed against vasoactive intestinal polypeptide (VIP), substance P (SP), neuron-specific enolase (NES), and the glial marker protein S100...
September 5, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28872701/natural-history-of-pancreatic-cystic-lesions-a-multicenter-prospective-observational-study-for-evaluating-the-risk-of-pancreatic-cancer
#12
Eizaburo Ohno, Yoshiki Hirooka, Hiroki Kawashima, Takuya Ishikawa, Akira Kanamori, Hideki Ishikawa, Yoji Sasaki, Koji Nonogaki, Kazuo Hara, Senju Hashimoto, Hiroshi Matsubara, Takanori Hirai, Hajime Sumi, Hiroyuki Sugimoto, Hidemi Goto
BACKGROUD AND AIM: To elucidate the natural history of pancreatic cystic lesions (PCLs), including branch-duct intraductal papillary mucinous neoplasm (BD-IPMN), via mid-term follow-up analysis of a multicenter prospective observational study (NSPINAL study). METHODS: From July 2011 to October 2016, 881 patients with PCLs were enrolled in NSPINAL study, and 664 patients with >12 months of follow-up were analysed. Every patient was asymptomatic, and endoscopic ultrasound (EUS) was performed at the initial diagnosis to exclude high-risk individuals...
September 5, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28872700/optimal-procedural-sequence-for-same-day-bidirectional-endoscopy-with-moderate-sedation-a-prospective-randomized-study
#13
Shuo-Wei Chen, Chi-Liang Cheng, Nai-Jen Liu, Jui-Hsiang Tang, Yen-Lin Kuo, Cheng-Hui Lin, Yi-Ning Tsui, Bai-Ping Lee, Hsiang-Ling Hung
BACKGROUND AND AIM: Same-day bidirectional endoscopy (BDE) is a commonly performed procedure, but the optimal sequence for the procedure with moderate conscious sedation is not well-established. We investigated the optimal sequence for same-day BDE under moderate conscious sedation and carbon dioxide insufflation in terms of sedation doses, patient discomfort, and colonoscopy performance. METHODS: We performed a prospective randomized controlled study of 120 patients who were scheduled for BDE examination...
September 5, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28865098/therapy-of-gerd-and-fd-overlap-with-symptoms-after-usual-dose-ppi-acotiamide-plus-usual-dose-ppi-vs-double-dose-ppi
#14
Toshihisa Takeuchi, Yoshiaki Takahashi, Shinpei Kawaguchi, Kazuhiro Ota, Satoshi Harada, Yuichi Kojima, Hiroki Sakamoto, Takanori Kuramoto, Keishi Kojima, Makoto Sanomura, Masahiro Hoshimoto, Takeshi Higashino, Tsukasa Itabashi, Ko Takada, Masahiro Sakaguchi, Kazunari Tominaga, Motoyasu Kusano, Kazuhide Higuchi
BACKGROUND AND AIM: Gastroesophageal reflux disease (GERD) and functional dyspepsia (FD) often coexist or overlap. In this study, the efficacy of acotiamide in combination with a standard dose of rabeprazole for GERD and FD was compared with that of a double dose of rabeprazole. METHODS: Patients with overlap between GERD and FD experiencing heartburn and epigastric fullness symptoms after standard-dose proton pump inhibitor (PPI) for ≥8 weeks were randomized into two groups, and received either acotiamide 300 mg/day + rabeprazole 10 mg/day or rabeprazole 20 mg/day for 4 weeks...
September 1, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28857324/physical-activity-levels-and-hepatic-steatosis-a-longitudinal-follow-up-study-in-adults
#15
Aline Mendes Gerage, Raphael Mendes Ritti-Dias, Babu Balagopal, Raquel Dilguerian de Oliveira Conceição, Daniel Umpierre, Raul Dias Dos Santos Filho, Gabriel Grizzo Cucato, Márcio Sommer Bittencourt
BACKGROUND AND AIM: This study aimed to evaluate the impact of physical activity (PA) on the course of hepatic steatosis (HS) in adults. METHODS: HS status (ultrasonography) and PA levels were evaluated in 5860 subjects at baseline and after approximately 2.5 years (range: 19-50 months). At follow-up possible exposures to different PA levels were: those who remained inactive, became inactive, became active, remained active. After follow-up, subjects were then classified according to the four possible states (outcomes): "remained without HS", "developed HS" (subjects without HS at baseline), "remained with HS", or "reverted HS"...
August 30, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28857255/efficacy-of-a-concomitant-elemental-diet-to-reduce-the-loss-of-response-to-adalimumab-in-patients-with-intractable-crohn-s-disease
#16
Naoko Sugita, Kenji Watanabe, Noriko Kamata, Tomomi Yukawa, Koji Otani, Shuhei Hosomi, Yasuaki Nagami, Fumio Tanaka, Koichi Taira, Hirokazu Yamagami, Tetsuya Tanigawa, Masatsugu Shiba, Toshio Watanabe, Kazunari Tominaga, Daijiro Kabata, Ayumi Shintani, Tetsuo Arakawa, Yasuhiro Fujiwara
BACKGROUND AND AIM: Secondary loss of response to adalimumab (ADA-LOR) commonly occurs in patients with Crohn's disease (CD) treated with ADA. We evaluated the efficacy of concomitant elemental diet (ED) therapy to reduce ADA-LOR in adult CD patients. METHODS: Patients were divided into either an ED (≥900 kcal/day) or a non-ED group (<900 kcal/day). Cumulative non-ADA-LOR rates were compared between groups. The effects of ED intake to reduce ADA-LOR was also assessed in anti-tumor necrosis factor-alpha (TNFα) naïve and infliximab (IFX)-intolerant or refractory CD patients...
August 30, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28843035/risk-prediction-of-post-hepatectomy-liver-failure-in-patients-with-perihilar-cholangiocarcinoma
#17
Eung Chang Lee, Sang-Jae Park, Sung-Sik Han, Jae Ryong Shim, Hyeong Min Park, Seung Duk Lee, Seong Hoon Kim
BACKGROUND AND AIM: In most patients with perihilar cholangiocarcinoma (PHCC), major hepatectomy and extrahepatic bile duct resection are needed for surgical radicality, and a high risk of hepatic insufficiency exists. This study aims to develop a prediction model for post-hepatectomy liver failure (PHLF) in patients with PHCC. METHODS: A total of 143 patients who underwent major liver resection and extrahepatic bile duct resection for PHCC between October 2001 and December 2013 were included...
August 26, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28840619/adding-c-reactive-protein-and-procalcitonin-to-the-meld-score-improves-mortality-prediction-in-patients-with-complications-of-cirrhosis
#18
Sakkarin Chirapongsathorn, Worawan Bunraksa, Amnart Chaiprasert, Dollapas Punpanich, Ouppatham Supasyndh, Patrick S Kamath
OBJECTIVE: To determine the performance of models adding C-reactive protein (CRP) and procalcitonin (PCT) to the MELD score for mortality prediction in patients hospitalized with complications of cirrhosis. PATIENTS AND METHODS: A prospective cohort study was carried out in consecutive cirrhotic patients admitted with complications of cirrhosis between September 2012 to December 2013 at Phramongkutklao Hospital, Bangkok, Thailand. All patients had venous CRP, PCT and laboratory values for MELD score calculation measured at emergency room or admission...
August 25, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28834565/utility-of-magnetic-resonance-elastography-for-predicting-ascites-in-patients-with-chronic-liver-disease
#19
Kazumichi Abe, Atsushi Takahashi, Hiromichi Imaizumi, Manabu Hayashi, Ken Okai, Yukiko Kanno, Naoya Sato, Akira Kenjo, Shigeru Marubashi, Hiromasa Ohira
OBJECTIVE: This study aimed to evaluate the utility of magnetic resonance elastography (MRE) as a non-invasive method for predicting ascites in patients with chronic liver disease (CLD). METHODS: A total of 208 CLD patients underwent MRE to measure liver stiffness (LS) at our institution from March 2013 to June 2015. We evaluated the diagnostic performance of MRE for predicting the presence of ascites using receiver-operating characteristic (ROC) curve analysis and compared the performance with that of serum fibrosis markers...
August 23, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28833619/cost-effective-options-for-the-prevention-and-management-of-gastrointestinal-and-liver-disease-in-the-asia-pacific-region
#20
REVIEW
Ian C Roberts-Thomson, Thomas Lung
The Asia-Pacific region contains more than half of the world's population and is markedly heterogeneous in relation to income levels and the provision of public and private health services. For low-income countries, the major health priorities are child and maternal health. In contrast, priorities for high-income countries include vascular disease, cancer, diabetes, dementia and mental health disorders as well as chronic inflammatory disorders such as hepatitis B and hepatitis C. Cost-effectiveness analyses are methods for assessing the gains in health relative to the costs of different health interventions...
August 17, 2017: Journal of Gastroenterology and Hepatology
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