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Journal of Gastroenterology and Hepatology

Jia-Horng Kao, Min-Lung Yu, Chi-Yi Chen, Cheng-Yuan Peng, Ming-Yao Chen, Huoling Tang, Qiaoqiao Chen, Jinzi J Wu
BACKGROUND AND AIM: The need for all-oral HCV treatments with higher response rates, improved tolerability and lower pill burden compared to interferon-inclusive regimen has led to the development of new direct-acting antiviral agents (DAAs). Ravidasvir (RDV) is a second-generation, pan-genotypic NS5A inhibitor with high barrier to resistance. The aim of this phase 2 study (EVERST study) was to assess the efficacy and safety of interferon-free, 12-week RDV plus ritonavir-boosted danoprevir (DNVr) and ribavirin (RBV) regimen for treatment-naïve Asian HCV genotype 1 (GT1) patients without cirrhosis...
January 18, 2018: Journal of Gastroenterology and Hepatology
Kazuhiko Shirakabe, Masaaki Higashiyama, Hirotaka Furuhashi, Takeshi Takajo, Koji Maruta, Yoshikiyo Okada, Chie Kurihara, Chikako Watanabe, Shunsuke Komoto, Kengo Tomita, Shigeaki Nagao, Soichiro Miura, Masayuki Saruta, Ryota Hokari
BACKGROUND AND AIM: Sphingosine-1-phosphate (S1P) receptor 1, a therapeutic target of the S1P1 agonist FTY720, plays a crucial role in lymphocyte migration and is expressed in several cells including naïve T lymphocytes and endothelial cells. 2-acetyl-4-tetrahydroxybutyl imidazole (THI), an inhibitor of S1P lyase (SPL), exhibits immunomodulatory activity through increasing the S1P concentration in the secondary lymphoid organs, but its effects on colitis remain unclear. We aimed to clarify how THI affects colitis and migration of naïve T lymphocytes in Peyer's patches (PPs)...
January 15, 2018: Journal of Gastroenterology and Hepatology
Ian C Roberts-Thomson
Humans and Helicobacter pylori have evolved and adapted over tens of thousands of years. Yet peptic ulcer disease appeared to be rare prior to the 19th century. The prevalence of peptic ulcer disease increased between 1850 and 1900 and culminated in a cohort at high risk that was born at the end of the 19th century. This coincided with the provision of safe water and improvements in sanitation and personal hygiene. One hypothesis for the emergence of peptic ulcer disease focuses on the rate of development of atrophic gastritis induced by Helicobacter pylori...
January 10, 2018: Journal of Gastroenterology and Hepatology
Yunsheng Yang, Jingyuan Fang, Xiaozhong Guo, Ning Dai, Xizhong Shen, Youlin Yang, Jing Sun, Bal Raj Bhandari, David S Reasner, Jacquelyn A Cronin, Mark G Currie, Jeffrey M Johnston, Peter Zeng, Niwat Montreewasuwat, George Zhijian Chen, Sam Lim
BACKGROUND AND AIM: Linaclotide is a guanylate cyclase-C agonist approved in multiple countries to treat irritable bowel syndrome with constipation (IBS-C). China has unmet need for well-tolerated therapy that is effective in treating both bowel and abdominal symptoms of IBS-C. This trial evaluated linaclotide's efficacy and safety in IBS-C patients in China and other regions. METHODS: This Phase 3, double-blind trial randomized IBS-C patients to once-daily oral 290-μg linaclotide or placebo at centers in China, North America, and Oceania...
January 10, 2018: Journal of Gastroenterology and Hepatology
Nam Hee Kim, Taeheon Lee, Yong Kyun Cho, Byung Ik Kim, Hong Joo Kim
BACKGROUND AND AIM: To determine the impact of clinically evident portal hypertension (CEPH) on prognosis of hepatocellular carcinoma (HCC) patients with Child-Pugh A cirrhosis who underwent transarterial chemoembolization (TACE). METHODS: A retrospective data analysis was performed for a total of 388 treatment-naïve HCC patients with Child-Pugh A cirrhosis who underwent TACE as first-line treatment from January 2000 to June 2014. Cumulative occurrence rate of complete response (CR), progression free survival (PFS), and overall survival (OS) were compared between patients with CEPH and those without CEPH [esophageal/gastric varices or low platelet count (<100,000/mm3 ) associated with splenomegaly]...
January 3, 2018: Journal of Gastroenterology and Hepatology
Xueqing Fang, Li Wei Liu, Jing Dong, Junfei Zhang, Haiyan Song, Youliang Song, Yizhe Huang, Xiaoling Cui, Jian Lin, Congxin Chen, Bo Liu, Zhaolin Chen, Jingjing Pan, Xi Chen
BACKGROUND: Our study was to investigate the immunomodulatory effect and short-term efficacy and long-term prognosis of decompensated liver cirrhosis patients caused by hepatitia B after a double transplantation with hUCMSCs. METHODS: 50 inpatients were recruited and given the same medical treatments, receiving hUCMSCs injection intravenously. 53 patients (group B) matched for age, sex, and baseline ALT, AST, albumin, TBIL, PT, and MELD score and Child-Pugh classification, acted as the control group...
January 2, 2018: Journal of Gastroenterology and Hepatology
Guang Qiu Yu, Xiao Mei Huang, Hai Yan Li, Wen Tang, Duan Min Hu, Mu Han Lü, Kuang-I Fu
BACKGROUND AND STUDY AIMS: Various methods have been reported as aids to cecal intubation. This study aimed to prospectively investigate whether an abdominal obstetric binder (AOB) used during pregnancy and attached to the patients' abdomen during colonoscopy could facilitate effective colonoscopic insertion. PATIENTS AND METHODS: This was a prospective study of 451 consecutive outpatient colonoscopies performed by a single experienced endoscopist. The recruited patients were randomly separated into two groups that received colonoscopy either with (Group A) or without an AOB attached (Group B)...
January 2, 2018: Journal of Gastroenterology and Hepatology
Werner Dammermann, Valentin Mihajlov, Barbara Middendorf, Alexander Mellmann, Helge Karch, Stefan Lüth, Sebastian Ullrich
BACKGROUND AND AIM: An outbreak of Shigatoxin 2 (Stx2) producing enterohemorrhagic and enteroaggregative E.coli (EHEC) O104:H4 infection in May 2011 in Germany caused enterocolitis and an unprecedented high 22% rate of hemolytic uremic syndrome (HUS). We hypothesized that anti-Stx2 IgM or IgG titers might predict HUS development. METHODS: 32 patients infected with EHEC O104:H4 (HUS: n=23;non-HUS: n=9) were retrospectively screened for anti-Stx2 IgM/IgG and matched with clinical data regarding HUS development, fever, superinfection, dialysis, neurological symptoms, intensive care, antibiotic treatment, and plasmapheresis...
December 27, 2017: Journal of Gastroenterology and Hepatology
Xue-Song Liu, Tao Chen, Li-Hong Gu, Yi-Fen Guo, Chun-Yang Li, Feng-Hua Li, Jian Wang
BACKGROUND AND AIM: Polypoid lesions of the gallbladder may be neoplastic or non-neoplastic. Correct diagnosis would help reduce unnecessary cholecystectomies. This study aimed to determine the predictive value of individual ultrasound characteristics for diagnosis of neoplastic polyps and to build a scoring system based on these characteristics. METHODS: A total of 109 patients with gallbladder polyps ≥ 6mm underwent conventional ultrasound examination and received finally diagnosis by pathological examination...
December 27, 2017: Journal of Gastroenterology and Hepatology
Norihisa Ishimura, Yoshikazu Kinoshita
Eosinophilic esophagitis (EoE) is a chronic inflammatory condition characterized by esophageal dysfunction and dense eosinophilic infiltration of esophageal epithelium. According to clinical consensus and guidelines published in 2011, esophageal eosinophilia was classified into 2 entities based on response to proton pump inhibitor (PPI) administration; EoE and PPI-responsive esophageal eosinophilia (PPI-REE). We have performed a series of investigations to determine whether EoE is actually different from PPI-REE...
December 26, 2017: Journal of Gastroenterology and Hepatology
Yoichiro Kawashita, Yuji Morine, Yu Saito, Chie Takasu, Tetsuya Ikemoto, Shuichi Iwahashi, Hiroki Teraoku, Masato Yoshikawa, Satoru Imura, Toshiyuki Yagi, Mitsuo Shimada
BACKGROUND: Heat shock factor 1 (HSF1), a master regulator of heat shock response, has been shown to play a multifaceted role in cancer progression. However, the clinical significance and biological effect of HSF1 expression in intrahepatic cholangiocarcinoma (IHCC) remain unknown. METHODS: Forty-nine patients with IHCC who underwent hepatic resection were enrolled in this study. HSF1 expression in tumor tissue was determined by immunohistochemistry, and patients were divided into two groups, those with high (n=20) and low (n=29) HSF1 expression...
December 26, 2017: Journal of Gastroenterology and Hepatology
Toru Setsu, Satoshi Yamagiwa, Kentaro Tominaga, Naruhiro Kimura, Hiroki Honda, Hiroteru Kamimura, Atsunori Tsuchiya, Masaaki Takamura, Shuji Terai
BACKGROUND & AIM: Mucosal-associated invariant T (MAIT) cells constitute a novel subset of innate-like T-lymphocytes characterized by a semi-invariant T-cell receptor repertoire capable of recognizing bacterial products. Considering the abundance of MAIT cells in the liver and the possible association between bacterial infections and primary biliary cholangitis (PBC), we aimed to analyze the involvement of MAIT cells in the immunopathogenesis of PBC. METHODS: Peripheral blood and liver biopsy specimens were collected from 25 patients with PBC and 19 patients with chronic viral hepatitis...
December 21, 2017: Journal of Gastroenterology and Hepatology
Matthew C Choy, Dean Seah, Alexandra Gorelik, Yoon-Kyo An, Cheng-Yu Chen, Finlay A Macrae, Miles P Sparrow, William R Connell, Gregory T Moore, Graham Radford-Smith, Daniel R Van Langenberg, Peter De Cruz
OBJECTIVES: Acute severe ulcerative colitis (ASUC) is a medical emergency requiring prompt therapeutic intervention. Although Infliximab has been used as salvage therapy for over 15 years, clinical predictors of treatment success are lacking. We performed a retrospective analysis to identify factors that predict colectomy and may guide dose intensification. METHODS: 54 hospitalized patients received infliximab for ASUC at 7 Australian centres (April 2014-May 2015)...
December 21, 2017: Journal of Gastroenterology and Hepatology
Bobin Hu, Rongming Wang, Jiaxin Fu, Minghua Su, Man Du, Yu Liu, Huijiao Li, Huiwen Wang, Fengmin Lu, Jianning Jiang
BACKGROUND & AIMS: To investigate the impact of hepatitis B virus (HBV) S gene integration on serum hepatitis B surface antigen (HBsAg) levels in chronic hepatitis B (CHB) with long-term nucleos(t)ide analogue (NUCs) therapy. METHODS: CHB patients who performed liver biopsy at baseline and treated with long-term NUCs therapy were recruited. The integration of HBV S gene in baseline liver biopsy specimen was detected by Alu-PCR method. Serum HBsAg levels were measured at baseline, the second year and the fourth year after NUCs therapy by Roche reagent respectively...
December 20, 2017: Journal of Gastroenterology and Hepatology
Yoshiaki Takahashi, Toshihisa Takeuchi, Yuichi Kojima, Yasuaki Nagami, Masaki Ominami, Noriya Uedo, Kenta Hamada, Haruhisa Suzuki, Ichiro Oda, Youichi Miyaoka, Satoshi Yamanouchi, Satoshi Tokioka, Naoya Tomatsuri, Norimasa Yoshida, Yuji Naito, Takashi Nonaka, Shinya Kodashima, Shinichi Ogata, Yasushi Hongo, Tadayuki Oshima, Zhaoliang Li, Kotaro Shibagaki, Tomoyuki Oikawa, Kazunari Tominaga, Kazuhide Higuchi
BACKGROUND & AIMS: In the treatment of patients after endoscopic submucosal dissection (ESD), there is no consensus on the optimum time to start Helicobacter pylori (H. pylori) eradication therapy or on whether eradication therapy improves ulcer healing rate after ESD. The aim of this study was to examine the effect of immediate eradication of H. pylori on ulcer healing after ESD in patients with early gastric neoplasms. METHODS: A total of 330 patients who underwent ESD for early gastric neoplasms were enrolled...
December 19, 2017: Journal of Gastroenterology and Hepatology
Surachate Siripongsakun, Sirachat Vidhyarkorn, Sirivipa Charuswattanakul, Poemlarp Mekraksakit, Prakongboon Sungkasubun, Nuphat Yodkhunnathum, Sutthirak Tangruangkiat, Napat Ritlumlert, Thaniya Sricharunrat, Sirima Jaroenpatarapesaj, Kamonwan Soonklang, Anond Kulthanmanusorn, Chirayu U Auewarakul, Chulabhorn Mahidol
BACKGROUND AND OBJECTIVE: Cholangiocarcinoma (CCA) is an aggressive malignancy with rapid progression and poor prognosis. Abdominal ultrasound surveillance may detect early-stage malignancy and improve surgical outcome. However, little data exists on the benefits of abdominal ultrasound surveillance in populations at high risk for CCA development in an endemic area. This study compared survival outcomes of CCA patients recruited through abdominal ultrasound surveillance program and those presented to the hospital independent of surveillance...
December 16, 2017: Journal of Gastroenterology and Hepatology
Wen-Lun Wang, Sherry Yueh-Hsia Chiu, Ching-Tai Lee, Cheng-Hao Tseng, Chien-Chuan Chen, Ming-Lun Han, Chen-Shuan Chung, Ping-Hsin Hsieh, Wei-Lun Chang, Ping-Hsiu Wu, Wen-Hung Hsu, Hsu-Heng Yen, Hsiu-Po Wang, Chi-Yang Chang
BACKGROUND: Optimal staging of the invasion depth of superficial esophageal squamous cell carcinoma (SESCC) is vital prior to endoscopic treatment. A new simplified magnified narrow-band imaging (M-NBI) classification system based on vascular architecture has recently been developed by the Japan Esophageal Society, however its validity remains uncertain. METHODS: A total of 11 experienced and 11 inexperienced endoscopists were invited to join an endoscopic training program, which was composed of pre-test, educational section, and post-test...
December 16, 2017: Journal of Gastroenterology and Hepatology
Won Hyeok Choe, Hong Kim, So-Young Lee, Yu-Min Choi, So Young Kwon, Hee Won Moon, Mina Hur, Bum-Joon Kim
BACKGROUND & AIMS: Naturally occurring hepatitis B virus variants carrying a deletion in the preS1 start codon region may evolve during long-lasting virus-host interactions in chronic hepatitis B (CHB). The aim of this study was to determine the immune phase-specific prevalent patterns of preS1 start codon deletion variants and related factors during the natural course of CHB. METHODS: A total of 399 CHB patients were enrolled. Genotypic analysis of three different preS1 start codon deletion variants (classified by deletion size: 15-bp, 18-bp, and 21-bp deletion variants) was performed...
December 12, 2017: Journal of Gastroenterology and Hepatology
Kuan-Chih Chen, Chen-Shuan Chung, Wei-Fan Hsu, Tien-Yu Huang, Cheng-Kuan Lin, Tzong-Hsi Lee, Meng-Tzu Weng, Cheng-Ming Chiu, Li-Chun Chang, Han-Mo Chiu
BACKGROUND AND AIMS: The incidence and disease burden of colorectal cancer (CRC) in young adults were increasing. However, there was a dearth of advice on how to identify young population at risk for neoplastic colonic polyps (NCPs) and CRC. We aimed to indentify risk factors for NCPs and CRC in young adults presenting with bloody stool. METHODS: 1,496 subjects younger than 40-year-old who underwent colonoscopy due to bloody stool from 2005 to 2014 were enrolled in this retrospective study as the study group, and 1481 age and gender matched asymptomatic subjects who underwent colonoscopy for health checkup from 2011 to 2016 were enrolled as the control group at a tertiary center hospital...
December 12, 2017: Journal of Gastroenterology and Hepatology
Tomonori Aoki, Atsuo Yamada, Yoshihiro Hirata, Hirohumi Suzuki, Ayako Nakada, Ryota Niikura, Motoko Seto, Makoto Okamoto, Kazuhiko Koike
BACKGROUND: Among patients with obscure gastrointestinal bleeding (OGIB), endoscopic ulcerative lesions in the small bowel have diverse etiologies and often cause rebleeding. Certain characteristics of patients or ulcerations may be reasonable indications for diagnostic balloon-assisted endoscopy (BAE) to assess etiology and may be risks of rebleeding; however, these characteristics are unclear. We aimed to elucidate appropriate indications for diagnostic BAE and predictors of long-term rebleeding in patients with small-bowel ulcerative lesions...
December 12, 2017: Journal of Gastroenterology and Hepatology
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