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Journal of Gastroenterology and Hepatology

Keiichi Akahoshi, Daisuke Ban, Ryo Kuboki, Atsushi Oba, Hiroaki Ono, Yusuke Mitsunori, Atsushi Kudo, Shinji Tanaka, Minoru Tanabe
BACKGROUND AND AIM: To improve the prognosis of cholangiocarcinoma, we investigated potential biomarkers that may enable the selection of patients for whom postoperative adjuvant chemotherapy is likely effective. METHODS: The cohort of this retrospective study included 170 surgically-resected cholangiocarcinoma patients, 26 with gemcitabine adjuvant chemotherapy (GEM group), 36 with S-1 adjuvant chemotherapy (S-1 group), and 103 receiving no adjuvant chemotherapy (NC group)...
September 22, 2018: Journal of Gastroenterology and Hepatology
Shin Ju Oh, Min-Goo Lee, Jung Rock Moon, Chang Kyun Lee, Sung-Gil Chi, Hyo Jong Kim
BACKGROUND AND AIM: Despite the frequent loss of Ras association domain family 1 isoform A (RASSF1A) expression in various cancers, the precise mechanism underlying its tumor suppressive effect is not fully understood. To elucidate the growth-inhibitory role for RASSF1A in colorectal tumorigenesis, this study investigated the RASSF1A regulation of the p53-p21WAF1 pathway. METHODS: RASSF1A effect on cellular growth was tested in three human colon cancer cell lines by flow cytometry, cell counting, and [3 H]-thymidine incorporation assay...
September 18, 2018: Journal of Gastroenterology and Hepatology
Rintaro Hashimoto, Tomoki Matsuda
No abstract text is available yet for this article.
September 17, 2018: Journal of Gastroenterology and Hepatology
Masashi Hirooka, Atsushi Hiraoka, Hironori Ochi, Yohei Koizumi, Kojiro Michitaka, Kouji Joko, Masanori Abe, Yoichi Hiasa
BACKGROUND & AIM: The aim of the present prospective study was to evaluate tumor recurrence (intrasubsegmental recurrence-free survival and local tumor recurrence-free survival) and hepatic functional reserve following no-touch ablation. METHODS: The prospective cohort study protocols were approved by the institutional ethics committee. All patients provided written, informed consent. Between January 2014 and September 2016, 231 patients with 277 hepatocellular carcinoma nodules were prospectively enrolled...
September 17, 2018: Journal of Gastroenterology and Hepatology
Yuki Ohta, Makoto Arai, Tomoo Nakagawa, Naoki Akizue, Kentaro Ishikawa, Shinsaku Hamanaka, Hirotaka Koseki, Takashi Taida, Kenichiro Okimoto, Keiko Saito, Sayuri Yoshihama, Daisuke Maruoka, Tomoaki Matsumura, Tatsuro Katsuno, Naoya Kato
BACKGROUND AND AIM: Venous thromboembolism (VTE) is a common complication of inflammatory bowel disease (IBD). The aim of the present study was to identify predictors of VTE in hospitalised patients with IBD. METHODS: Patients with IBD who were hospitalised from February 2015 to March 2016 at the Chiba University Hospital were included. VTE was detected using enhanced computed tomography and VTE onset within 2 months after admission was assessed. Predictors of VTE onset were investigated with clinical factors during hospitalisation...
September 17, 2018: Journal of Gastroenterology and Hepatology
Chan Hyuk Park, Hyunki Kim, Jeong Hyeon Jo, Kyu Yeon Hahn, Jung-Ho Yoon, Soon Young Kim, Yong Chan Lee, Sung Hoon Noh, Hyun Cheol Chung, Sang Kil Lee
BACKGROUND: A high yield of biopsy is mandatory to perform molecular genetic research with endoscopically obtained gastric cancer tissues. We evaluated whether probe-based confocal laser endomicroscopy (pCLE) can increase the yield of endoscopic biopsy for gastric cancer compared with white light endoscopy (WLE). METHODS: All lesions in the pCLE and WLE groups were initially evaluated through WLE. In the pCLE group, lesions were further examined through pCLE. In the pilot study, five and three biopsy specimens were obtained for histopathological examination and tumor marker analysis, respectively...
September 17, 2018: Journal of Gastroenterology and Hepatology
Søren Møller, Else La Cour Sibbesen, Jan Lysgård Madsen, Flemming Bendtsen
BACKGROUND & AIMS: Patients with cirrhosis and portal hypertension often develop complications relating to hepatic excretory dysfunction. The standard measurement of the hepatic excretion is the constant infusion indocyanine green clearance (ICGCI ) technique. The ICG 15-minutes retention test (ICG-r15) is faster, more patient friendly and cheaper. The aims were to compare the ICG-r15 test with the standard method, to assess relations to patient characteristics and survival, and to assess the ICG-r15 level in healthy control subjects...
September 17, 2018: Journal of Gastroenterology and Hepatology
Dan-Qing Liu, Hang Zhang, Le Xiao, Bing-Yin Zhang, Wei-Hui Liu
OBJECTIVES: To assess the clinical validity and safety of single-operator cholangioscopy system (SOCS) for the treatment of concomitant gallbladder stones and secondary common bile duct (CBD) stones. METHODS: This retrospective study included 10 consecutive patients who had small-sized stones (<1 cm) in both the gallbladder and CBD; the patients underwent SOCS treatment from June 2016 to December 2016. The clinical validity of this minimally invasive surgery was determined by the operation success rate, stone removal rate, postoperative hospital stay, hospitalization cost, and contrast images before and after the operation...
September 14, 2018: Journal of Gastroenterology and Hepatology
J Lu, X-Z Xiong, N-S Cheng
No abstract text is available yet for this article.
September 14, 2018: Journal of Gastroenterology and Hepatology
Yinglian Xiao, Yuwen Li, Jianchang Shu, Yan Li, Jianming Xu, Jianlin Ren, Deliang Liu, Jiangbin Wang, Liya Zhou, Yanqing Li, Guodou Tang, De'an Tian, Shutian Zhang, Xiaohua Hou, Huahong Wang, Zhaoshen Li, Nonghua Lv, Minhu Chen
BACKGROUND AND AIMS: The treatment of patients with functional dyspepsia (FD) remains unsatisfactory. We assessed the efficacy of Zhizhu Kuanzhong (ZZKZ) Capsule, a traditional Chinese medicine formula, in patients with postprandial distress syndrome (PDS) of FD. METHODS: The study was designed as a multicenter, randomized, double-blinded, controlled clinical trial. 392 patients with PDS defined by Rome III criteria from 16 centers in China were randomly assigned to receive either ZZKZ or placebo...
September 11, 2018: Journal of Gastroenterology and Hepatology
X Xu, L Cong, Y Zhao
No abstract text is available yet for this article.
September 6, 2018: Journal of Gastroenterology and Hepatology
Yoshihide Matsumoto, Kazuyo Ota, Hajime Yamada
No abstract text is available yet for this article.
September 3, 2018: Journal of Gastroenterology and Hepatology
Amit Goel, Nicole Seguy, Rakesh Aggarwal
INTRODUCTION: Burden of hepatitis C in India is not known. We therefore conducted a systematic review of the available data on anti-HCV seroprevalence in the Indian population. METHODS: We searched several publication databases for English language papers that reported data on anti-HCV seroprevalence from India, and also identified other unpublished sources of such data. Data on groups likely to represent seroprevalence in general population and in selected high-risk groups were extracted and subjected to meta-analysis...
September 3, 2018: Journal of Gastroenterology and Hepatology
Junyan Qu, Haixu Jian, Lixiang Li, Yan Zhang, Bingcheng Feng, Zhen Li, Xiuli Zuo
BACKGROUND AND AIM: Removal of neoplastic polyps is important for colorectal cancer prevention. The primary aim was to compare the complete resection rate of diminutive (≤5 mm) or small colorectal polyps (6-10 mm) using cold snare polypectomy (CSP) versus hot snare polypectomy (HSP). METHODS: To April 2018, databases of Medline, EMBASE, Cochrane Central Register of Controlled Trials, and Web of Science were searched for randomized controlled trials comparing CSP and HSP for diminutive or small colorectal polypectomy...
September 3, 2018: Journal of Gastroenterology and Hepatology
Rui Feng, Jing Guo, Sheng-Hong Zhang, Yun Qiu, Bai-Li Chen, Yao He, Zhi-Rong Zeng, Shomron Ben-Horin, Min-Hu Chen, Ren Mao
BACKGROUND AND AIMS: Measuring 6- thioguanine nucleotide (6-TGN) level is useful in optimizing dose of azathioprine (AZA) and monitoring for toxicity. Lower dose of AZA was suggested for maintenance of clinical remission in Asian patients than Caucasian patients with Crohn's disease (CD). However, the optimal 6-TGN threshold required in Asian patients is undetermined. Therefore, the aim of the current study is to explore the optimal 6-TGN threshold required in Asian patients with CD for maintenance of clinical remission...
September 3, 2018: Journal of Gastroenterology and Hepatology
Masao Kobayakawa, Shin Ohnishi, Hidekazu Suzuki
Gastric varices (GVs) are a major complication of portal hypertension in patients with liver cirrhosis. The mortality rate associated with the bleeding from GVs is not low. Balloon-occluded retrograde transvenous obliteration (BRTO) was first introduced by Kanagawa et al. as a treatment for isolated GVs in 1994. It has been performed most frequently in Asia, especially in Japan. Ethanolamine oleate was the original sclerosant used in the therapy. Since the late 2000s, BRTO using sodium tetradecyl sulfate foam or polidocanol foam as a sclerosant has been performed in many countries other than Japan...
August 31, 2018: Journal of Gastroenterology and Hepatology
Yee Hui Yeo, Chia-Chen Hsu, Chiao-Chin Lee, Hsiu J Ho, Jaw-Town Lin, Ming-Shiang Wu, Jyh-Ming Liou, Chun-Ying Wu
BACKGROUND AND AIM: The eradication rate of Helicobacter pylori has been declining over the past decades. A rescue plan is needed for increasing populations with treatment failure. However, the optimum second-line eradication regimen remains inconclusive. We conducted a network meta-analysis to assess the comparative effectiveness of second-line Helicobacter pylori (H. pylori) eradication therapies and determine the optimum regimen. METHODS: We searched electronic databases from January 2005 to Feb 2018 for randomized controlled trials assessing the effectiveness of second-line regimens in patients with persistent H...
August 31, 2018: Journal of Gastroenterology and Hepatology
Keisuke Kakisaka, Yuji Suzuki, Yudai Fujiwara, Akiko Suzuki, Jo Kanazawa, Yasuhiro Takikawa
BACKGROUND & AIMS: Lipotoxicity causes liver inflammation, which leads to non-alcoholic steatohepatitis (NASH). Lysophosphatidylcholine (LPC) is a causal agent of lipotoxicity. Recently, lysophosphatidylcholine acyltransferase (LPCAT) was identified as an enzyme that catalyzes the esterification of LPC, which potentially decreases LPC levels. However, the effect of LPCAT in lipotoxicity of the liver is not fully understood. Our aim was to determine whether LPCAT attenuates lipotoxicity in the liver...
August 30, 2018: Journal of Gastroenterology and Hepatology
Ritsuzo Kozuka, Masaru Enomoto, Misako Sato-Matsubara, Kanako Yoshida, Hiroyuki Motoyama, Atsushi Hagihara, Hideki Fujii, Sawako Uchida-Kobayashi, Hiroyasu Morikawa, Akihiro Tamori, Norifumi Kawada, Yoshiki Murakami
BACKGROUND & AIMS: It remains unclear whether there is an association between single nucleotide polymorphisms (SNPs) and development of hepatocellular carcinoma (HCC) during entecavir (ETV) treatment in nucleos (t) ide analog (NA)-naïve patients with chronic hepatitis B virus infection. We investigated the risk factors for HCC, especially host factors, during ETV treatment. METHODS: A total of 127 Japanese patients undergoing ETV treatment were enrolled in this study...
August 30, 2018: Journal of Gastroenterology and Hepatology
Daniel de la Iglesia, Nicolau Vallejo-Senra, Andrea López-López, Julio Iglesias-Garcia, Jose Lariño-Noia, Laura Nieto-García, J Enrique Domínguez-Muñoz
BACKGROUND: Previous studies have suggested that chronic pancreatitis (CP) is associated with increased risk of cardiovascular (CV) disease independently of other major risk factors. We evaluated the risk of CV events in a well-phenotyped cohort of patients with CP and its association with pancreatic exocrine insufficiency (PEI) among other CV risk factors. METHODS: Prospective, longitudinal cohort study of patients with CP, followed-up at the Pancreas Unit of the University Hospital of Santiago de Compostela, Spain...
August 29, 2018: Journal of Gastroenterology and Hepatology
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