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Journal of Gastroenterology and Hepatology

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https://www.readbyqxmd.com/read/28332731/undiagnosed-pancreatic-exocrine-insufficiency-and-chronic-pancreatitis-in-functional-gi-disorder-patients-with-diarrhea-or-abdominal-pain
#1
N J Talley, G Holtmann, N Q Nguyen, P R Gibson, P Bampton, M Veysey, J Wong, S Philcox, N Koloski, L Bunby, M Jones
BACKGROUND & AIMS: A previous UK study showed that 6.1% of patients with diarrhea-predominant IBS (IBS-D) had evidence of severe pancreatic exocrine insufficiency (PEI), but these findings need replication. We aimed to identify the prevalence of PEl based on faecal elastase stool testing in consecutive outpatients presenting with chronic unexplained abdominal pain and/or diarrhea and/or IBS-D. METHODS: Patients aged over 40 years presenting to hospital outpatient clinics from 6 sites within Australia with unexplained abdominal pain and/or diarrhea for at least 3 months and/or IBS-D were studied...
March 23, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28321907/systematical-analyses-of-variants-in%C3%A2-dnase-i-hypersensitive-sites-identified-two-novel-hepatocellular-carcinoma-susceptibility-loci-among-chinese-population
#2
Tao Jiang, Fangzhi Du, Na Qin, Qun Lu, Juncheng Dai, Hongbing Shen, Zhibin Hu
BACKGROUND AND AIM: Although several variants located at coding and non-coding regions were evaluated by previous studies, the evidence for associations between variants located in DNase I-hypersensitive sites (DHSs) and hepatocellular carcinoma (HCC) risk was still limited. Recent advances using ENCODE data indicated that genetic variants in DHSs played an important role in carcinogenesis. Therefore, systematically investigate the associations between regulatory variants in DHSs and HCC risk should be put on the agenda...
March 20, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28303605/performance-of-scoring-systems-to-predict-mortality-of-patients-with-acute-on-chronic-liver-failure-a-systematic-review-and-meta-analysis
#3
Yi-Xiang Zheng, Xiao Zhong, Ya-Jun Li, Xue-Gong Fan
BACKGROUND: Acute-on-chronic liver failure (ACLF) has characteristic feature of multisystem organ failure, rapid progression and low early transplant-free survival. AIM: We performed a meta-analysis to determine the accuracy of five scoring systems in predicting mortality of ACLF patients. METHODS: A systematic database search was performed and retrieved articles were graded according to methodological quality. Collated data was meta-analyzed by hierarchical summarized receiver operating characteristic (HSROC) model and bivariate model to evaluate the diagnostic accuracy of scoring systems RESULT: Of 4223 studies identified, 26 studies involving 4732 ACLF patients were included...
March 16, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28299830/repeated-water-avoidance-stress-induces-visceral-hypersensitivity-role-of-il-1-il-6-and-peripheral-corticotropin-releasing-factor
#4
Tsukasa Nozu, Saori Miyagishi, Rintaro Nozu, Kaoru Takakusaki, Toshikatsu Okumura
BACKGROUND AND AIM: Repeated water avoidance stress (WAS) induces visceral hypersensitivity. Additionally, it is also known to activate corticotropin-releasing factor (CRF), mast cells and pro-inflammatory cytokines systems, but their precise roles on visceral sensation have not been determined definitely. The aim of the study was to explore this issue. METHODS: Abdominal muscle contractions induced by colonic balloon distention, i.e. visceromotor response (VMR) was detected electrophysiologically in conscious rats...
March 15, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28299819/arsenic-trioxide-combined-with-transarterial-chemoembolization-for-primary-liver-cancer-a-meta-analysis
#5
Xiu-He Lv, Chun-Hui Wang, Yan Xie
BACKGROUND: The benefit of combination therapy of arsenic trioxide (As2 O3 ) and transarterial chemoembolization (TACE) is debated. This meta-analysis was conducted to determine whether As2 O3 & TACE therapy achieves better therapeutic effects compared with TACE alone for primary liver cancer. METHODS: A systematic search of both English and Chinese databases was conducted for randomised controlled trials (RCTs). The main outcomes were therapeutic responses, survival rates, improvement in quality of life, and adverse events...
March 15, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28299813/improvement-of-liver-stiffness-in-patients-with-hepatitis-c-virus-infection-who-received-direct-acting-antiviral-therapy-and-achieved-sustained-virological-response
#6
Toshifumi Tada, Takashi Kumada, Hidenori Toyoda, Kazuyuki Mizuno, Yasuhiro Sone, Saki Kataoka, Shinichi Hashinokuchi
BACKGROUND AND AIM: There is insufficient research on whether direct-acting antiviral (DAA) therapy can improve liver fibrosis in patients with chronic hepatitis C virus (HCV). We evaluated sequential changes in liver stiffness using shear wave elastography (SWE) in patients with HCV who received DAA therapy. METHODS: A total of 210 patients with HCV who received daclatasvir and asunaprevir therapy and achieved sustained virological response (SVR) were analyzed...
March 15, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28295549/uric-acid-ameliorates-indomethacin-induced-enteropathy-in-mice-through-its-antioxidant-activity
#7
Yuichi Yasutake, Kengo Tomita, Masaaki Higashiyama, Hirotaka Furuhashi, Kazuhiko Shirakabe, Takeshi Takajo, Koji Maruta, Hirokazu Sato, Kazuyuki Narimatsu, Kenichi Yoshikawa, Yoshikiyo Okada, Chie Kurihara, Chikako Watanabe, Shunsuke Komoto, Shigeaki Nagao, Hirotaka Matsuo, Soichiro Miura, Ryota Hokari
BACKGROUND AND AIM: Uric acid is excreted from blood into the intestinal lumen, yet the roles of uric acid in intestinal diseases remain to be elucidated. In this study, we aimed to determine whether uric acid could reduce endpoints associated with nonsteroidal anti-inflammatory drug (NSAID)-induced enteropathy. METHODS: A mouse model of NSAID-induced enteropathy was generated by administering indomethacin intraperitoneally to 8-week-old male C57BL/6 mice, and then vehicle or uric acid was administered orally...
March 14, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28294403/novel-strategies-for-the-treatment-of-acute-pancreatitis-based-on-the-determinants-of-severity-okuda-state-of-the-art-lecture
#8
John A Windsor, Alistair Escott, Lisa Brown, Anthony R J Phillips
Acute pancreatitis (AP) is a common disease for which a specific treatment remains elusive. The key determinants of the outcome from AP are persistent organ failure and infected pancreatic necrosis. The prevention and treatment of these determinants provides a framework for the development of specific treatment strategies. The gut-lymph concept provides a common mechanism for systemic inflammation and organ dysfunction. Acute and critical illness, including AP, is associated with intestinal ischaemia and drastic changes in the composition of gut lymph, which bypasses the liver to drain into the systemic circulation immediately proximal to the major organ systems which fail...
March 14, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28295594/the-albi-grade-predicts-the-prognosis-of-patients-with-advanced-hepatocellular-carcinoma-received-sorafenib
#9
Yuan-Hung Kuo, Jing-Houng Wang, Chao-Hung Hung, Kun-Ming Rau, I-Pei Wu, Chien-Hung Chen, Kwong-Ming Kee, Tsung-Hui Hu, Sheng-Nan Lu
BACKGROUND: The Albumin-Bilirubin (ALBI) grade is a new index to assess objectively liver function and prognosis in patients with hepatocellular carcinoma (HCC). This study aimed to elucidate the application of ALBI grade in baseline and sorafenib-end in advanced HCC patients received sorafenib. PATIENTS AND METHODS: A total of 415 consecutive advanced HCC patients in Child-Pugh A received sorafenib in our hospital. Sorafenib was terminated when radiologic tumor progression, or clinical liver function deterioration (LD) occurred in the reassessment bi-monthly...
March 11, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28295587/validation-of-non-invasive-methods-to-predict-the-presence-of-gastroesophageal-varices-in-a-cohort-of-patients-with-compensated-advanced-chronic-liver-disease
#10
Elba Llop, Marta Lopez, Juan de la Revilla, Natalia Fernandez, Maria Trapero, Marta Hernandez, Carlos Fernandez, Fernando Pons, Jose Luis Martinez, Jose Luis Calleja
INTRODUCTION: The aim was to validate non-invasive methods to predict the presence of gastroesophageal varices (GEV) in patients with suspected compensated advanced chronic liver disease (cACLD). METHODS: We retrospectively reviewed clinical and radiological data collected prospectively between September 2013 and September 2015. We reviewed 442 consecutive patients with suspected cACLD measured by transient elastography (TE) and a gastroscopy. We evaluated platelets, spleen diameter, TE, LSPS (liver stiffness x spleen size /platelets), variceal risk index (VRI), Baveno VI strategy and Augustin algorithm...
March 11, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28294404/improved-classification-of-indeterminate-biliary-strictures-by-probe-based-confocal-laser-endomicroscopy-using-the-paris-criteria-following-biliary-stenting
#11
Pushpak Taunk, Satish Singh, David Lichtenstein, Virendra Joshi, Jason Gold, Ashish Sharma
BACKGROUND AND AIMS: Probe-based confocal laser endomicroscopy (pCLE) using the Miami Criteria has improved classification of indeterminate biliary strictures. However, previous biliary stenting may result in their misclassification as malignant strictures. Inflammatory criteria were added to form the Paris Classification to prevent this misclassification and reduce false positives. The aim of this study was to assess if the Paris Classification was more accurate than the Miami Classification in classifying indeterminate biliary strictures after biliary stenting...
March 11, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28271564/acute-kidney-injury-predicts-mortality-in-cirrhotic-patients-with-gastric-variceal-bleeding
#12
Yun-Cheng Hsieh, Kuei-Chuan Lee, Ping-Hsien Chen, Chien-Wei Su, Ming-Chih Hou, Han-Chieh Lin
BACKGROUND & AIM: The International Club of Ascites (ICA) recently proposed a new definition of AKI in cirrhotic patients. We evaluated the ICA-AKI criteria and their association with the prognosis of cirrhotic patients with gastric variceal bleeding (GVB). METHODS: A retrospective cohort study using prospective database of cirrhotic patients hospitalized with the first presentation of acute GVB at Taipei Veterans General Hospital from April 2007 to December 2010 was performed to evaluate the development of AKI...
March 8, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28266772/mortality-and-hemorrhagic-complications-associated-with-radiofrequency-ablation-for-treatment-of-hepatocellular-carcinoma-in-patients-on-hemodialysis-for-end-stage-renal-disease-a-nationwide-survey
#13
Masaya Sato, Ryosuke Tateishi, Hideo Yasunaga, Hiroki Matsui, Hiromasa Horiguchi, Kiyohide Fushimi, Kazuhiko Koike
BACKGROUND AND AIMS: Because of the rarity of invasive treatment for hepatocellular carcinoma (HCC) in patients on hemodialysis (HD) for end-stage renal disease (ESRD), the risks associated with radiofrequency ablation (RFA) in such patients remain uncertain. We used a nationwide database to investigate in-hospital mortality and hemorrhagic complications following RFA in patients on HD for ESRD. METHODS: Using the Japanese Diagnosis Procedure Combination database, we enrolled patients on HD for ESRD who underwent RFA for HCC...
March 7, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28261881/alterations-in-microrna-expression-profiles-in-inflamed-and-non-inflamed-ascending-colon-mucosae-of-patients-with-active-crohn-s-disease
#14
Lu Yi Wu, Xiao Peng Ma, Yin Shi, Chun Hui Bao, Xiao Ming Jin, Yuan Lu, Ji Meng Zhao, Ci Li Zhou, Dai Chen, Hui Rong Liu
BACKGROUND AND AIMS: The miRNA expression profiles of the terminal ileum, sigmoid colon, and rectal mucosa of adult patients with active Crohn';s disease (CD) have been previously reported. The purpose of this study was to identify dysregulated miRNAs in the mucosa of the ascending colon. METHODS: Biopsy tissue samples were taken from the mucosae of inflammatory (iCD) or non-inflammatory (niCD) areas of the ascending colons of adult patients with active CD. miRNA and mRNA expression profiles were detected using microarray analyses...
March 5, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28258705/daclatasvir-and-asunaprevir-treatment-in-patients-with-severe-liver-fibrosis-by-hcv-genotype-1b-infection-real-world-data
#15
Masatoshi Ishigami, Kazuhiko Hayashi, Takashi Honda, Teiji Kuzuya, Yoji Ishizu, Tetsuya Ishikawa, Isao Nakano, Fumihiro Urano, Takashi Kumada, Kentaro Yoshioka, Hidemi Goto, Yoshiki Hirooka
BACKGROUNDS AND AIMS: In this study, we investigated the real-world data of the first approved interferon free regimen in Japan; daclatasvir as asunaprevir in chronic hepatitis C patients with severe fibrosis. PATIENTS AND METHODS: Among 924 patients registered in our multicenter study, 535 patients were defined as having severe fibrosis with Fib-4 index≧3.25, and were included in this study. We investigated anti-viral effect and factors associated with SVR12, and the additional effects on serum AFP and albumin levels by eradicating virus in patients who attained SVR were investigated...
March 4, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28251689/germline-mutations-in-patients-with-multiple-colorectal-polyps-in-china
#16
Chen-Guang Li, Peng Jin, Lang Yang, Wan-Chun Zang, Qian Kang, Na Li, Yuqi He, Junfeng Xu, Chen Zhang, Xin Wang, Jian-Qiu Sheng
BACKGROUND AND AIM: Multiple colorectal polyps are relevant in hereditary colorectal cancer (CRC) syndromes, which are thought to be caused by multiple events including germline mutations. This study was aimed to characterize germline mutations in Chinese patients with multiple colorectal polyps. METHODS: Patients with >10 colorectal polyps at the Department of Gastroenterology of the PLA Army General Hospital were enrolled from January 2014 to December 2015...
March 2, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28251684/influence-of-age-at-diagnosis-on-the-clinical-characteristics-of-crohn-s-disease-in-korea-results-from-the-connect-study
#17
Sung Wook Hwang, Jee Hyun Kim, Jong Pil Im, Byong Duk Ye, Hoon Sup Koo, Kyu Chan Huh, Jae Hee Cheon, You Sun Kim, Young Ho Kim, Dong Soo Han, Won Ho Kim, Joo Sung Kim
BACKGROUND AND AIM: The present study evaluated the clinical characteristics of Korean patients with Crohn's disease (CD) according to their age at diagnosis in a nationwide multicenter cohort study. METHODS: A total of 1,224 patients diagnosed with CD between 1982 and 2008 in 32 hospitals were included, and age at diagnosis was categorized as ≤ 16 (G1), 17-40 (G2), 41-59 (G3) and ≥ 60 (G4) years old. The baseline characteristics, medication, and intestinal resection were compared according to the age at diagnosis...
March 2, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28245345/variations-in-primary-sclerosing-cholangitis-across-the-age-spectrum
#18
John E Eaton, Bryan M McCauley, Elizabeth J Atkinson, Brian D Juran, Erik M Schlicht, Mariza de Andrade, Konstantinos N Lazaridis
BACKGROUND & AIM: Primary sclerosing cholangitis (PSC) typically develops in middle-age adults. Little is known about phenotypic differences when PSC is diagnosed at various ages. Therefore, we sought to compare the clinical characteristics of a large PSC cohort based on the age when PSC was diagnosed. METHODS: We performed a multicenter retrospective review to compare the features of PSC among those diagnosed between 1-19 years (yrs) (n = 95), 20-59 yrs (n = 662), and 60-79 yrs (n = 102)...
February 28, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28244198/cross-cultural-and-psychological-issues-in-irritable-bowel-syndrome
#19
REVIEW
Swapnajeet Sahoo, Susanta Kumar Padhy
Irritable Bowel Syndrome (IBS) is one of the most common functional gastrointestinal disorders encountered by gastroenterologists worldwide. Of all the etiological factors which had been postulated to explain the pathophysiology of IBS, cultural and psychological factors are unique and difficult to understand. Culture plays an important role in coloring the presentation of IBS and many a times, it has a significant role in several treatment aspects too. Psychological aspects like personality profiles, family relationships, societal myths, abuse in any form etc...
February 27, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28240420/clinical-utility-of-multipolar-ablation-with-a-three-dimensional-simulator-system-for-patients-with-liver-cancer
#20
Masashi Hirooka, Yohei Koizumi, Yusuke Imai, Yoshiko Nakamura, Atsushi Yukimoto, Takao Watanabe, Osamu Yoshida, Yoshio Tokumoto, Masanori Abe, Yoichi Hiasa
BACKGROUND AND AIM: To confirm the efficacy of multipolar ablation with a new simulator system, 3D sim-Navigator, for patients with hepatocellular carcinoma by assessing relapse-free survival and shape of the ablation volume under clinical conditions. METHODS: All participants provided written, informed consent, and study protocols were approved by the institutional ethics committee. Twenty-seven patients with 27 nodules were treated by no-touch ablation using the new simulator system...
February 27, 2017: Journal of Gastroenterology and Hepatology
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