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Journal of Gastroenterology and Hepatology

Gino L Sarri, Sam E Grigg, Neville D Yeomans
BACKGROUND AND AIM: Owing to wide-spread use, low-dose aspirin (LDA) produces a substantial amount of peptic ulcer disease. Current guidelines are ambivalent about the need for Helicobacter pylori eradication to protect against LDA ulcers. This study aimed to determine, through meta-analysis, if (and by how much) infection alters the baseline risk of peptic ulcers during LDA therapy. METHODS: Literature screening was performed in MEDLINE and EMBASE from inception to May 2018...
November 8, 2018: Journal of Gastroenterology and Hepatology
Yu-Qiang Cheng, Kang Wang, Xiu-Ping Zhang, Xu-Biao Wei, Ya-Bo Jiang, Yi-Ren Hu, Fei-Fei Mao, Wei-Xing Guo, Jie Shi, Shu-Qun Cheng
BACKGROUND: Portal vein tumor thrombus (PVTT) predicts a poor prognosis in hepatocellular carcinoma (HCC) patients. Platelets (PLTs) play an important role in HCC progression and metastasis. However, the relationship between PLTs and PVTT remains unclear. This study aimed to evaluate the value of PLT counts in the prognosis of HCC patients with PVTT after hepatectomy. METHODS: From January 2002 to December 2012, 694 HCC patients with PVTT after hepatectomy were evaluated...
November 7, 2018: Journal of Gastroenterology and Hepatology
Shunji Koya, Takumi Kawaguchi, Ryuki Hashida, Keisuke Hirota, Masafumi Bekki, Emiko Goto, Maiko Yamada, Masako Sugimoto, Saki Hayashi, Norihiro Goshima, Teruhito Yoshiyama, Takashi Otsuka, Ryosuke Nozoe, Ayu Nagamatsu, Dan Nakano, Tomotake Shirono, Shigeo Shimose, Hideki Iwamoto, Takashi Niizeki, Hiroo Matsuse, Hironori Koga, Hiroko Miura, Naoto Shiba, Takuji Torimura
BACKGROUND AND AIMS: Sarcopenia is a prognostic factor in hepatocellular carcinoma (HCC) patients. HCC patients who underwent transcatheter arterial chemoembolization (TACE) are at a risk of muscle atrophy. We aimed to investigate the effects of in-hospital exercise on muscle mass and factors associated with muscle hypertrophy in HCC patients who underwent TACE. METHODS: We enrolled 209 HCC patients who underwent TACE. Patients were classified into either an Exercise (n=102) or Control (n=107) group...
November 7, 2018: Journal of Gastroenterology and Hepatology
Henry Lik Yuen Chan
Nucleos(t) ide analogues (NA) are effective, safe, and convenient antiviral therapy to suppress replication of hepatitis B virus (HBV), which can be translated into improved long-term outcome of chronic hepatitis B patients. The current recommended first-line NA, namely entecavir and tenofovir, are largely free from problems of drug resistance. Nonetheless, there are still a few challenges in the era of NA. First, the risk of hepatocellular carcinoma (HCC) can only be reduced but not eliminated, particularly among cirrhotic patients...
November 6, 2018: Journal of Gastroenterology and Hepatology
Jindong Zhang, Lijin Song, Yujing Wang, Chang Liu, Lu Zhang, Shiwei Zhu, Shuangjiang Liu, Liping Duan
BACKGROUND AND AIM: Emerging evidence indicates that psychological stress is involved in the pathogenesis of irritable bowel syndrome (IBS), which is characterized by visceral hypersensitivity and may be accompanied by gut dysbiosis. However, how such stress contributes to the development of visceral hypersensitivity is incompletely understood. Here, we aimed to investigate the influence that stress-induced microbial changes exert on visceral sensitivity, as well as the possible underlying mechanisms associated with this effect...
November 6, 2018: Journal of Gastroenterology and Hepatology
Takuya Adachi, Kazuhiro Nouso, Koji Miyahara, Atsushi Oyama, Nozomu Wada, Chihiro Dohi, Yasuto Takeuchi, Tetsuya Yasunaka, Hideki Onishi, Fusao Ikeda, Shinichiro Nakamura, Hidenori Shiraha, Akinobu Takaki, Hiroyuki Takabatake, Shin-Ichi Fujioka, Haruhiko Kobashi, Yoshitaka Takuma, Shouta Iwadou, Shuji Uematsu, Koichi Takaguchi, Hiroaki Hagihara, Hiroyuki Okada
BACKGROUND: Several factors, including proangiogenic cytokines, have been reported as predictive markers for the treatment effect of sorafenib in patients with hepatocellular carcinoma (HCC); however, most of them were determined based on one-time measurements prior to treatment. METHODS: We consecutively recruited 80 advanced HCC patients who were treated with sorafenib prospectively. Serum levels of eight proangiogenic cytokines and the appearance of adverse events were monitored periodically, and their correlations with the prognoses of the patients were evaluated...
November 6, 2018: Journal of Gastroenterology and Hepatology
Kai Song, Wei Su, Yanlong Liu, Jiahui Zhang, Qirui Liang, Na Li, Qingzhou Guan, Jun He, Xuefeng Bai, Wenyuan Zhao, Zheng Guo
BACKGROUND AND AIM: Differentially expressed (DE) genes detected at the population-level through case-control comparison provide no information on the dysregulation frequencies of DE genes in a cancer. In this work, we aimed to identify the genes with universally up- or down-regulated expressions in colorectal cancer. METHODS: We firstly clarified that DE genes in an individual cancer tissue should be the disease-relevant genes which are dysregulated in the cancer tissue in comparison with its own previously normal state...
November 5, 2018: Journal of Gastroenterology and Hepatology
Yuki Toyokawa, Tomohisa Takagi, Kazuhiko Uchiyama, Katsura Mizushima, Ken Inoue, Chihiro Ushiroda, Saori Kashiwagi, Takahiro Nakano, Yuma Hotta, Makoto Tanaka, Osamu Dohi, Tetsuya Okayama, Naohisa Yoshida, Kazuhiro Katada, Kazuhiro Kamada, Takeshi Ishikawa, Osamu Handa, Hideyuki Konishi, Yuji Naito, Yoshito Itoh
BACKGROUND AND AIM: Daikenchuto, a traditional Japanese herbal medicine, has been reported to exhibit anti-inflammatory effects against intestinal inflammation. However, whether daikenchuto has a therapeutic effect against intestinal mucosal injuries remains unclear. Thus, the aim of this study was to determine the effect of daikenchuto on intestinal mucosal healing. METHODS: Colitis was induced in male Wistar rats by using trinitrobenzenesulfonic acid. Daikenchuto (900 mg/kg/day) was administered for 7 days after the induction of colitis...
November 5, 2018: Journal of Gastroenterology and Hepatology
Ankur A Dashputre, Branden D Nemecek, Khalid M Kamal, Jordan R Covvey
BACKGROUND/AIM: Patients with liver cirrhosis are impacted by comorbidities that affect healthcare utilization and survival. The study objective was to assess the relationship between a cirrhosis-specific comorbidity scoring system (CirCom) and healthcare utilization among patients with cirrhosis. METHODS: A retrospective cohort analysis was conducted using electronic medical records (EMR) from a large academic-based healthcare network. Patients aged 18-90 years with at least one ICD-9-CM diagnosis code for cirrhosis (571...
November 5, 2018: Journal of Gastroenterology and Hepatology
Ryo Nakagomi, Ryosuke Tateishi, Ryota Masuzaki, Yoko Soroida, Tomomi Iwai, Mayuko Kondo, Naoto Fujiwara, Masaya Sato, Tatsuya Minami, Koji Uchino, Kenichiro Enooku, Hayato Nakagawa, Yoshinari Asaoka, Yuji Kondo, Yasuo Tanaka, Motoyuki Otsuka, Naoya Kato, Kyoji Moriya, Hitoshi Ikeda, Kazuhiko Koike
BACKGROUND: Liver stiffness (LS), measured by transient elastography, has been validated as a non-invasive surrogate for liver fibrosis. METHODS: We investigated the long-term predictive ability of LS for hepatocellular carcinoma (HCC) development and overall survival in 1146 patients with chronic hepatitis C by using LS value at enrollment. We also investigated chronological changes in LS based on anti-viral therapy and its outcome in 752 patients. RESULTS: During the mean follow-up period of 6...
November 4, 2018: Journal of Gastroenterology and Hepatology
Shao-Zhuo Huang, Zhi-Cheng Liu, Wei-Xin Liao, Jun-Xiao Wei, Xiao-Wen Huang, Chen Yang, Yu-Han Xia, Lu Li, Chao Ye, Shi-Xue Dai
BACKGROUND AND AIM: The thiopurines are effective in the management of patients with inflammatory bowel disease (IBD), but the association between thiopurines use and the risk of skin cancer (including nonmelanoma skin cancer [NMSC] and melanoma skin cancer [MSC]) has already been sufficiently reported. However, the results of these studies are inconsistent and thus the objective of our analysis was to explore whether thiopurines can lead to an excess risk of skin cancer in IBD patients...
November 4, 2018: Journal of Gastroenterology and Hepatology
Yusuf Aydemir, Zuhal Akcoren, Hulya Demir, Inci Nur Saltik Temizel, Hasan Ozen, Aysel Yuce
BACKGROUND AND AIM: We aimed to examine the frequency and the characteristics of IgG4-associated autoimmune hepatitis among pediatric patients with autoimmune hepatitis. METHODS: Immunostaining for IgG and IgG4 were performed in liver biopsies of 40 pediatric patients with autoimmune hepatitis. The patients with more than 10 IgG4-positive plasma cells/HPF were defined as IgG4-associated autoimmune hepatitis. Clinic, laboratory and histopathological results were compared between groups...
October 30, 2018: Journal of Gastroenterology and Hepatology
Jung Hyun Jo, Chang Min Cho, Jae Hyuck Jun, Moon Jae Chung, Tae Hyeon Kim, Dong Wan Seo, Jaihwan Kim, Do Hyun Park
Background and Aims Few studies compared endoscopic ultrasound (EUS)-guided fine needle aspiration (EUS-FNA) with endoscopic retrograde cholangiopancreatography (ERCP)-based tissue sampling in terms of diagnostic accuracy in suspected malignant biliary obstruction. We evaluated and compared the diagnostic performance of EUS-FNA and ERCP-based tissue sampling. METHODS: This multicenter study included 263 patients with suspected malignant biliary obstruction who underwent same-session EUS and ERCP between 2012 and 2016...
October 30, 2018: Journal of Gastroenterology and Hepatology
Young Hoon Kim, Jee Hyun Kim, Byeong Gwan Kim, Kook Lae Lee, Ji Won Kim, Seong-Joon Koh
BACKGROUND AND AIM: Inflammatory bowel diseases (IBD) is associated with an increased risk for the development of colorectal cancer. However, the mechanism of immune signaling pathways linked to colitis-associated cancer (CAC) has not been fully elucidated. Tauroursodeoxycholic acid (TUDCA) exhibits anti-inflammatory and anti-cancer activities. The aim of this study is to investigate the role of TUDCA in the pathogenesis of CAC. METHODS: CAC was induced in mice using azoxymethane (AOM) and dextran sodium sulfate (DSS) administration, and TUDCA's effect on tumor development was evaluated...
October 30, 2018: Journal of Gastroenterology and Hepatology
Hee Kyong Na, Ji Yong Ahn, Gin Hyug Lee, Jeong Hoon Lee, Do Hoon Kim, Kee Wook Jung, Kee Don Choi, Ho June Song, Hwoon-Yong Jung
BACKGROUND AND AIMS: We developed a novel training simulator for percutaneous endoscopic gastrostomy (PEG), and determined its efficacy and realism in PEG insertion training. METHODS: The gastrostomy simulator was made using three-dimensional (3D) printing and silicone molding technology. The simulator is of two types: pull type and introducer type. We enrolled 20 participants, comprising 10 beginners with no experience of PEG insertion and 10 PEG-experienced endoscopists...
October 29, 2018: Journal of Gastroenterology and Hepatology
Takuya Iwamoto, Masaki Maeda, Issei Saeki, Isao Hidaka, Kunihiko Tajima, Tsuyoshi Ishikawa, Taro Takami, Isao Sakaida
AIM: The goals of the study were to identify an effective treatment for ascites and to examine the influence of tolvaptan on outcomes by investigating non-responders to tolvaptan and comparing outcomes of hepatic cirrhosis in patients treated with and without tolvaptan. METHODS: In Study 1, of 145 patients with hepatic cirrhosis who were treated with tolvaptan between September 2013 and March 2018, 45 who did not achieve weight loss of ‚Č•1.5 kg within one week were investigated...
October 29, 2018: Journal of Gastroenterology and Hepatology
Sha Chen, Weijia Duan, Min Li, Shuxiang Li, Tingting Lv, Qiuju Tian, Qianyi Wang, Xiaoning Wu, Xinyan Zhao, Xiaoming Wang, Yu Wang, Yuanyuan Kong, Hong Ma, Xiaojuan Ou, Hong You, Jidong Jia
BACKGROUND & AIMS: The impact of male sex and past hepatitis B virus (HBV) infection on survival of primary biliary cholangitis (PBC) are issues at discussion. The aim of the present study was to identify risk factors for transplant-free survival (TRS) in Chinese PBC patients who received ursodeoxycholic acid (UDCA), with special focus on the impact of male sex and past HBV infection. METHODS: We followed up PBC patients who received UDCA at our institute between January 2000 and December 2017 until their death, liver transplantation, or censored on April 1, 2018, by interview and review of medical records...
October 26, 2018: Journal of Gastroenterology and Hepatology
Takuji Kawamura, Shiho Nakamura, Daiki Sone, Hiroaki Sakai, Kana Amamiya, Naonori Inoue, Naokuni Sakiyama, Atsushi Shirakawa, Yusuke Okada, Kasumi Sanada, Kojiro Nakase, Koichiro Mandai, Azumi Suzuki, Atsuhiro Morita, Kiyohito Tanaka, Koji Uno, Kenjiro Yasuda
BACKGROUND & AIMS: Because the risk of colorectal cancer (CRC) has not been well examined in fecal immunochemistry test (FIT)-positive patients who previously underwent colonoscopy, this study aimed to investigate this topic. METHODS: This was a single-center, observational study of prospectively collected data in Japan. FIT-positive, average-risk patients who underwent colonoscopy were divided into groups as follows: (1) those who never underwent colonoscopy in the past (no colonoscopy group), (2) those with a history of colonoscopy between 6 months and 5 years (0...
October 24, 2018: Journal of Gastroenterology and Hepatology
Jingjing Rong, Shuzhan Liu, Chao Hu, Chen Liu
BACKGROUND AND AIM: Chronic inflammation is a major contributor to the initiation and progression of cancers. Lactobacillus helveticus NS8, which was originally separated from fermented koumiss, exhibited anti-inflammatory functions in our prior studies. In this study, NS8 was investigated for its potential to prevent colitis-associated colorectal cancer (CAC). METHODS: The protective effects of NS8 against CAC was explored by employing the azoxymethane (AOM) plus dextran sodium sulfate (DSS)-induced carcinogenesis mouse model...
October 24, 2018: Journal of Gastroenterology and Hepatology
Michael Frank, Salma Adham, Franck Zinzindohoué, Xavier Jeunemaitre
BACKGROUND AND AIM: Vascular Ehlers-Danlos syndrome (vEDS) is a rare connective tissue disorder due to heterozygous mutations in the COL3A1 gene with a dominant negative effect. Spontaneous bowel perforation and intra-abdominal organ rupture are common complications of vEDS. Other gastrointestinal (GI) manifestations may occur but have not been extensively characterized. We herein describe the natural history of GI events and surgery related complications in patients with vEDS. METHODS: A retrospective review of GI events in a large cohort of molecularly proven vEDS patients was conducted, after exclusion of mild forms of the disease...
October 24, 2018: Journal of Gastroenterology and Hepatology
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