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Journal of Controlled Release: Official Journal of the Controlled Release Society

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https://www.readbyqxmd.com/read/30005907/modular-approach-for-theranostic-polymer-conjugates-with-activatable-fluorescence-impact-of-linker-design-on-the-stimuli-induced-release-of-doxorubicin
#1
REVIEW
Gregor Nagel, Harald R Tschiche, Stefanie Wedepohl, Marcelo Calderón
The introduction of cleavable motifs by dynamic covalent chemistry is widely applied in the design of drug delivery systems (DDS) to introduce controlled release properties. Since the cleavable moieties can be triggered by various exogenous or endogenous stimuli, the choice of the linker has substantial implications on the performance of the DDS. Here, we present a pair of theranostic polymer conjugates (TPC) to study the influence of the cleavable bond on the cell-mediated drug release by a facile in vitro fluorescence assay...
July 10, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/30005906/non-invasive-tri-modal-visualisation-via-pet-spect-%C3%AE-ct-of-recombinant-human-bone-morphogenetic-protein-2-retention-and-associated-bone-regeneration-a-proof-of-concept
#2
Gry Hulsart-Billström, Ram Kumar Selvaraju, Sergio Estrada, Mark Lubberink, Veronika Asplund, Kristoffer Bergman, Richard Marsell, Sune Larsson, Gunnar Antoni
Bone morphogenetic proteins (BMP's) are vital for bone and cartilage formation, where bone morphogenetic protein-2 (BMP-2) is acknowledged as a growth factor in osteoblast differentiation. However, uncontrolled delivery may result in adverse clinical effects. In this study we investigated the possibility for longitudinal and non-invasive monitoring of implanted [125 I]BMP-2 retention and its relation to ossification at the site of implantation. A unilateral critically sized femoral defect was produced in the left limb of rats while the right femur was retained intact as a paired reference control...
July 10, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/30005905/monocultures-of-primary-porcine-brain-capillary-endothelial-cells-still-a-functional-in-vitro-model-for-the-blood-brain-barrier
#3
REVIEW
Hans-Joachim Galla
The main obstacle for the treatment of brain diseases is the restriction of the passage of pharmaceuticals across the blood-brain barrier. Endothelial cells line up the cerebral micro vessels and prevent the uncontrolled transfer of polar substances by intercellular tight junctions. In addition to this physical barrier, active transporters of the multi-drug-resistance prevent the passage of hydrophobic substances by refluxing them back to the blood stream. This paper reviews the development and selected applications of an in vitro porcine brain derived primary cell culture system established in the authors lab that closely resembles the BBB in vivo and could thus be used to study beyond other applications drug delivery to the brain...
July 10, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29990526/hydrogel-forming-microneedles-enhance-transdermal-delivery-of-metformin-hydrochloride
#4
Eman M Migdadi, Aaron J Courtenay, Ismaiel A Tekko, Maelíosa T C McCrudden, Mary-Carmel Kearney, Emma McAlister, Helen O McCarthy, Ryan F Donnelly
We investigated, for the first time, the potential for a hydrogel-forming microneedle (MN) patch to deliver the high-dose drug metformin HCl transdermally in a sustained manner. This may minimize some gastrointestinal side effects and small intestine absorption variations associated with oral delivery. Patches (two layers) were assembled from a lyophilised drug reservoir layer, with the MN layer made from aqueous blend of 20% w/w poly (methylvinylether-co-maleic acid) crosslinked by esterification with 7.5% w/w poly (ethylene glycol) 10,000 Da...
July 7, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29990525/a-preclinical-evaluation-of-a-programmable-cnt-membrane-device-for-transdermal-nicotine-delivery-in-hairless-guinea-pigs
#5
Gaurav Kumar Gulati, Lily Rachel Berger, Bruce Jackson Hinds
Nicotine replacement therapy in the form of transdermal nicotine patches and nicotine gums combined with behavioral counseling still has a low smoking cessation rate of 25%. A promising approach to smoking cessation is to remotely program variable transdermal nicotine delivery rates, with inputs from counselor and patient through a smartphone counseling application. A switchable carbon nanotube (CNT) membrane device has been developed for transdermal nicotine delivery that can be programmed to deliver variable doses matching those of nicotine patches (7, 14 and 21 mg/24 h) and nicotine gums (2 mg /4 mg)...
July 7, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29981357/injectable-and-protease-degradable-hydrogel-for-sirna-sequestration-and-triggered-delivery-to-the-heart
#6
Leo L Wang, Jennifer J Chung, Elizabeth C Li, Selen Uman, Pavan Atluri, Jason A Burdick
Injectable hydrogels have significant therapeutic potential for treatment of myocardial infarction (MI) through tissue bulking and local drug delivery, particularly for small interfering RNAs (siRNAs). As siRNA targets are identified as potential treatments for MI, hydrogels may bolster efficacy through local and sustained release. Here, we designed an injectable hydrogel to respond to local upregulation in proteolytic activity after MI to erode and release siRNA against MMP2 (siMMP2), a target implicated in deleterious remodeling...
July 4, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/30004000/pegylated-enhanced-cell-penetrating-peptide-nanoparticles-for-lung-gene-therapy
#7
Gizem Osman, Jason Rodriguez, Sze Yan Chan, Jane Chisholm, Gregg Duncan, Namho Kim, Amanda L Tatler, Kevin M Shakesheff, Justin Hanes, Jung Soo Suk, James E Dixon
The lung remains an attractive target for the gene therapy of monogenetic diseases such as cystic fibrosis (CF). Despite over 27 clinical trials, there are still very few gene therapy vectors that have shown any improvement in lung function; highlighting the need to develop formulations with improved gene transfer potency and the desirable physiochemical characteristics for efficacious therapy. Herein, we introduce a novel cell penetrating peptide (CPP)-based non-viral vector that utilises glycosaminoglycan (GAG)-binding enhanced transduction (GET) for highly efficient gene transfer...
July 3, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29980110/corrigendum-to-design-and-optimization-of-plga-microparticles-for-controlled-and-local-delivery-of-neuregulin-1-in-traumatic-spinal-cord-injury-journal-of-controlled-release-261-2017-147-162
#8
Kallivalappil T Santhosh, Arsalan Alizadeh, Soheila Karimi-Abdolrezaee
No abstract text is available yet for this article.
July 3, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29966689/prolonged-engraftment-of-transplanted-hepatocytes-in-the-liver-by-transient-pro-survival-factor-supplementation-using-ex-vivo-mrna-transfection
#9
Akitsugu Matsui, Satoshi Uchida, Akimasa Hayashi, Kazunori Kataoka, Keiji Itaka
Cell transplantation therapy needs engraftment efficiency improvement of transplanted cells to the host tissues. Ex vivo transfection of a pro-survival gene to transplanted cells is a possible solution; however prolonged expression and/or genomic integration of the gene can be cancer promoting. To supply pro-survival protein only when it is needed, we used mRNA transfection, which exhibits transient protein expression profiles without the risk of genomic integration. Ex vivo transfection of mRNA encoding Bcl-2, a pro-survival factor, led to enhanced hepatocyte engraftment in both of normal and diseased mouse liver, effectively supporting liver function in a model of chronic hepatitis...
June 29, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29964135/polymer-based-carriers-for-ophthalmic-drug-delivery
#10
REVIEW
Julieta C Imperiale, Gabriela B Acosta, Alejandro Sosnik
Despite the wide range of diseases affecting the eye, ocular bioavailability remains a challenge in ophthalmic drug delivery. Nowadays an extensive variety of polymers are being explored to develop colloidal drug carriers which show better performance than the more popular solutions. For instance, regardless of the type of polymer used, these systems prolong the residence time of the drug in the absorption site with respect to conventional aqueous eye drops which are rapidly cleared from eye surface. Furthermore, colloidal drug carriers can be internalized by cells...
June 29, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29964137/on-the-way-to-precision-formulation-additives-2d-screening-to-select-solubilizers-with-tailored-host-and-release-capabilities
#11
REVIEW
D Remmler, T Schwaar, M Pickhardt, C Donth, E Mandelkow, M G Weller, H G Börner
A 2-dimensional high-throughput screening method is presented to select peptide sequences from large peptide libraries for precision formulation additives, having a high capacity to specifically host a drug of interest and provide tailored drug release properties. The identified sequences are conjugated with poly(ethylene glycol) (PEG) to obtain peptide-PEG conjugates that proved to be valuable as solubilizers for small organic molecule drugs to overcome limitations of poor water-solubility and low bio-availability...
June 28, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29964136/an-inhibitor-screen-identifies-histone-modifying-enzymes-as-mediators-of-polymer-mediated-transgene-expression-from-plasmid-dna
#12
Matthew D Christensen, Rajeshwar Nitiyanandan, Seyedehmelika Meraji, René Davis, Sudhakar Godeshala, Sheba Goklany, Karmella Haynes, Kaushal Rege
Effective transgene expression in mammalian cells relies on successful delivery, cytoplasmic trafficking, and nuclear translocation of the delivered vector, but delivery is impeded by several formidable physicochemical barriers on the surface of and within the target cell. Although methods to overcome cellular exclusion and endosomal entrapment have been studied extensively, strategies to overcome inefficient nuclear entry and subsequent intranuclear barriers to effective transient gene expression have only been sparsely explored...
June 28, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29964134/immune-responses-induced-by-nano-self-assembled-lipid-adjuvants-based-on-a-monomycoloyl-glycerol-analogue-after-vaccination-with-the-chlamydia-trachomatis-major-outer-membrane-protein
#13
Letícia Rodrigues, Konstantinos N Raftopoulos, Signe Tandrup Schmidt, Fabian Schneider, Hendrik Dietz, Thomas Rades, Henrik Franzyk, Anders Elm Pedersen, Christine M Papadakis, Dennis Christensen, Gerhard Winter, Camilla Foged, Madlen Hubert
Nanocarriers based on inverse hexagonal liquid crystalline phases (hexosomes) show promising potential as vaccine delivery systems. Their unique internal structure, composed of both lipophilic domains and water-containing channels, renders them capable of accommodating immunopotentiating compounds and antigens. However, their adjuvant properties are poorly understood. We hypothesized that the supramolecular structure of the lyotropic liquid crystalline phase influences the immunostimulatory activity of lipid-based nanocarriers...
June 28, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29964133/the-effect-of-light-sensitizer-localization-on-the-stability-of-indocyanine-green-liposomes
#14
Tatu Lajunen, Riikka Nurmi, Danny Wilbie, Teemu Ruoslahti, Niklas G Johansson, Ossi Korhonen, Tomasz Rog, Alex Bunker, Marika Ruponen, Arto Urtti
Light triggered drug delivery systems offer attractive possibilities for sophisticated therapy, providing both temporal and spatial control of drug release. We have developed light triggered liposomes with clinically approved indocyanine green (ICG) as the light sensitizing compound. Amphiphilic ICG can be localized in different compartments of the liposomes, but the effect of its presence, on both triggered release and long term stability, has not been studied. In this work, we report that ICG localization has a significant effect on the properties of the liposomes...
June 28, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29958912/selective-self-induced-stimulus-amplification-prodrug-platform-for-inhibiting-multidrug-resistance-and-lung-metastasis
#15
Chenfeng Xu, Yu Sun, Yan Qi, Yulin Yu, Yangzhou He, Mei Hu, Qian Hu, Tingting Wu, Dan Zhang, Lihuan Shang, Huan Deng, Zhiping Zhang
Tumor heterogeneity is considered as one of main obstacles to limit the clinical application of stimuli-responsive nanocarriers. Multidrug resistance (MDR) is also a major challenge in cancer chemotherapy. Here, we developed a tumor redox heterogeneity-responsive prodrug with self-induced reactive oxygen species (ROS) amplification property for facilitating rapid drug release and overcoming MDR and lung metastasis. The prodrug can self-assemble into polymer micelles (PMs) with high drug loading content (~30%), good physiological stability, prolonged systemic circulation and enhanced tumor distribution...
June 26, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29940204/saccharides-oligosaccharides-and-polysaccharides-nanoparticles-for-biomedical-applications
#16
REVIEW
Farzad Seidi, Ratchapol Jenjob, Treethip Phakkeeree, Daniel Crespy
Modern requirements for designing efficient nanocarriers against diseases such as cancer are very complex. A suitable nanocarrier should indeed remain colloidally stable in the body, be biodegradable, target specific tumor cells, and release efficiently drugs. These challenging tasks can be overcome by using the chemistry of saccharides and polysaccharides. We discuss here recent applications of carbohydrates-based materials for providing biodegradability, enhancing contrast in bioimaging, a stealth effect for controlling the composition of protein corona, and targeting ability...
June 22, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29936118/neutralization-of-negative-charges-of-sirna-results-in-improved-safety-and-efficient-gene-silencing-activity-of-lipid-nanoparticles-loaded-with-high-levels-of-sirna
#17
Yusuke Sato, Hideki Matsui, Risa Sato, Hideyoshi Harashima
Lipid nanoparticles (LNPs) are one of the leading technologies for the in vivo delivery of short interfering RNA (siRNA). Cationic lipids are an important component for efficient endosomal escape via membrane fusion followed by release of siRNAs in cytosol where the site of action is located. A high cationic lipid/siRNA charge ratio is usually necessary for maximizing the gene silencing activity of the siRNA-loaded LNPs. However, high levels of cationic lipids are known to cause cytotoxicity through interactions with negatively charged biocomponents...
June 21, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29932959/synergy-between-chemical-permeation-enhancers-and-drug-permeation-across-the-tympanic-membrane
#18
Rong Yang, Obiajulu S Okonkwo, David Zurakowski, Daniel S Kohane
Chemical permeation enhancers (CPEs) can enable antibiotic flux across the tympanic membrane. Here we study whether combinations of CPEs (sodium dodecyl sulfate, limonene, and bupivacaine hydrochloride) are synergistic and whether they could increase the peak drug flux. Synergy is studied by isobolographic analysis and combination indices. CPE concentration-response (i.e. trans-tympanic flux of ciprofloxacin) curves are constructed for each CPE, isobolograms constructed for pairs of CPEs, and synergy demonstrated for all three pairs...
June 19, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29913222/a-multifunctional-multimaterial-system-for-on-demand-protein-release
#19
REVIEW
Deniz Ceylan Tuncaboylu, Fabian Friess, Christian Wischke, Andreas Lendlein
In order to provide best control of the regeneration process for each individual patient, the release of protein drugs administered during surgery may need to be timely adapted and/or delayed according to the progress of healing/regeneration. This study aims to establish a multifunctional implant system for a local on-demand release, which is applicable for various types of proteins. It was hypothesized that a tubular multimaterial container kit, which hosts the protein of interest as a solution or gel formulation, would enable on-demand release if equipped with the capacity of diameter reduction upon external stimulation...
June 15, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29913221/cell-penetrating-peptides-in-ocular-drug-delivery-state-of-the-art
#20
REVIEW
S Pescina, C Ostacolo, I M Gomez-Monterrey, M Sala, A Bertamino, F Sonvico, C Padula, P Santi, A Bianchera, S Nicoli
Despite the increasing number of effective therapeutics for eye diseases, their treatment is still challenging due to the presence of effective barriers protecting eye tissues. Cell Penetrating Peptides (CPPs), synthetic and natural short amino acid sequences able to cross cellular membrane thanks to a transduction domain, have been proposed as possible enhancing strategies for ophthalmic delivery. In this review, a general description of CPPs classes, design approaches and proposed cellular uptake mechanisms will be provided to the reader as an introduction to ocular CPPs application, together with an overview of the main problems related to ocular administration...
June 15, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
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