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Journal of Controlled Release: Official Journal of the Controlled Release Society

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https://www.readbyqxmd.com/read/28232226/nanodrug-delivery-systems-for-targeting-the-endogenous-tumor-microenvironment-and-simultaneously-overcoming-multidrug-resistance-properties
#1
REVIEW
Rui Li, Yan Xie
Multidrug resistance (MDR) is a major obstacle to successful cancer therapy, especially for chemotherapy. Endogenous stimulus-responsive nanosystems (ESRNs), which were developed on the basis of the pathophysiological characteristics of the endogenous tumor microenvironment, have emerged as an efficient cancer therapy and have played an increasingly important role particularly in combating MDR cancers. These nanosystems can control the drug-releasing pattern temporally and spatially and can improve the accumulation of chemotherapeutic agents in MDR tumors or cells...
February 20, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28232225/design-of-calcium-phosphate-ceramics-for-drug-delivery-applications-in-bone-diseases-a-review-of-the-parameters-affecting-the-loading-and-release-of-the-therapeutic-substance
#2
REVIEW
Marianne Parent, Hiva Baradari, Eric Champion, Chantal Damia, Marylène Viana-Trecant
Effective treatment of critical-size defects is a key challenge in restorative surgery of bone. The strategy covers the implantation of biocompatible, osteoconductive, bioactive and biodegradable devices which (1) well interact with native tissue, mimic multi-dimensional and hierarchical structure of bone and (2) are able to enhance bone repair, treating post implantation pathologies or bone diseases by local delivery of therapeutic agents. Among different options, calcium phosphate biomaterials are found to be attractive choices, due to their excellent biocompatibility, customisable bioactivity and biodegradability...
February 20, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28232224/silk-elastinlike-protein-polymers-enhance-the-efficacy-of-a-therapeutic-glycosaminoglycan-for-prophylactic-treatment-of-radiation-induced-proctitis
#3
Mark Martin Jensen, Wanjian Jia, Kyle J Isaacson, Austin Schults, Joseph Cappello, Glenn D Prestwich, Siam Oottamasathien, Hamidreza Ghandehari
Radiation-induced proctitis (RIP) is the most common clinical adverse effect for patients receiving radiotherapy as part of the standard course of treatment for ovarian, prostate, colon, and bladder cancers. RIP limits radiation dosage, interrupts treatment, and lowers patients' quality of life. A prophylactic treatment that protects the gastrointestinal tract from deleterious effects of radiotherapy will significantly improve patient quality of life and may allow for higher and more regular doses of radiation therapy...
February 20, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28232223/engineered-polymeric-nanoparticles-to-guide-the-cellular-internalization-and-trafficking-of-small-interfering-ribonucleic-acids
#4
REVIEW
Amy E Arnold, Petro Czupiel, Molly Shoichet
Ribonucleic acid interference therapy is a promising cancer treatment, which uses small interfering RNAs (siRNAs) to target and degrade messenger RNAs. Due to endogenous nuclease activity, siRNA is degraded rapidly, resulting in poor cell uptake and hence specificity. Moreover, it will not readily cross the cell membrane by passive diffusion. In order to take advantage of the therapeutic power of siRNA for the treatment of cancer, specialized delivery vehicles have been designed. In this review, we highlight advances in optimizing nanoparticle functionalization for guided siRNA delivery at the cellular level - that is, promoting cell uptake, escaping the endosome, and releasing siRNA from the delivery vehicle...
February 20, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28215671/dual-ligand-%C3%AE-5%C3%AE-1-and-%C3%AE-6%C3%AE-4-integrin-targeting-enhances-gene-delivery-and-selectivity-to-cancer-cells
#5
Rachel M Levine, Efrosini Kokkoli
Nanoparticles functionalized with cancer-targeting ligands have shown promise but are still limited by off-tumor binding to healthy tissues that express low levels of the molecular target. Targeting two cancer biomarkers using dual-targeted heteromultivalent nanoparticles presents a possible solution to this challenge by requiring overexpression of two separate ligands for localization. In order to guide experimental design, a kinetic model was built to explore how the affinity and valency of dual-ligand liposomes affect the binding and selectivity of delivery to cells with various receptor expression...
February 16, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28215670/therapeutic-efficacy-of-combined-pegylated-liposomal-doxorubicin-and-radiofrequency-ablation-comparing-single-and-combined-therapy-in-young-and-old-mice
#6
Alexander V Andriyanov, Emma Portnoy, Erez Koren, Sara Eyal, S Nahum Goldberg, Yechezkel Barenholz
Antitumor therapy in the elderly is particularly challenging due to multiple, often chronic diseases, poly-therapy, and age-related physiological changes that affect drug efficacy and safety. Furthermore, tumors may become more aggressive and drug-resistant with advanced age, leading to poor patient prognosis. In this study, we evaluated in mice bearing medulloblastoma xenografts the effect of age on tumor progression and tumor therapy. We focused on therapeutic efficacy of two treatment modalities alone radiofrequency ablation therapy (RFA), PEGylated liposomal doxorubicin (PLD) equivalent to Doxil, and their combination...
February 16, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28215669/new-drug-candidates-for-liposomal-delivery-identified-by-computer-modeling-of-liposomes-remote-loading-and-leakage
#7
Ahuva Cern, David Marcus, Alexander Tropsha, Yechezkel Barenholz, Amiram Goldblum
Remote drug loading into nano-liposomes is in most cases the best method for achieving high concentrations of active pharmaceutical ingredients (API) per nano-liposome that enable therapeutically viable API-loaded nano-liposomes, referred to as nano-drugs. This approach also enables controlled drug release. Recently, we constructed computational models to identify APIs that can achieve the desired high concentrations in nano-liposomes by remote loading. While those previous models included a broad spectrum of experimental conditions and dealt only with loading, here we reduced the scope to the molecular characteristics alone...
February 16, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28215668/potential-of-surfactant-coated-nanoparticles-to-improve-brain-delivery-of-arylsulfatase-a
#8
Tilman Schuster, Astrid Mühlstein, Claudia Yaghootfam, Olga Maksimenko, Elena Shipulo, Svetlana Gelperina, Jörg Kreuter, Volkmar Gieselmann, Ulrich Matzner
The lysosomal storage disorder (LSD) metachromatic leukodystrophy (MLD) is caused by a deficiency of the soluble, lysosomal hydrolase arylsulfatase A (ASA). The disease is characterized by accumulation of 3-O-sulfogalactosylceramide (sulfatide), progressive demyelination of the nervous system and premature death. Enzyme replacement therapy (ERT), based on regular intravenous injections of recombinant functional enzyme, is in clinical use for several LSDs. For MLD and other LSDs with central nervous system (CNS) involvement, however, ERT is limited by the blood-brain barrier (BBB) restricting transport of therapeutic enzymes from the blood to the brain...
February 16, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28215667/microneedle-bio-microneedle-and-bio-inspired-microneedle-a-review
#9
REVIEW
Guojun Ma, Chengwei Wu
Microneedles (MNs) are micro-scale needles used for drug delivery and other targets. Micro-scale size endows them with many advantages over hypodermic needles, including painlessness, minimal invasiveness and convenient operation, but it may also lead to risk of mechanical failures, which should be prevented in the clinical applications of MNs. The objective of this review is mainly to introduce studies on the mechanics problems with respect to MNs. Firstly, the basic knowledge of MNs is introduced in brief, so that readers can understand the basic characteristics of MNs...
February 16, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28213274/differentially-cleaving-peptides-as-a-strategy-for-controlled-drug-release-in-human-retinal-pigment-epithelial-cells
#10
Madhushree Bhattacharya, Sanjay Sarkhel, Jonne Peltoniemi, Robert Broadbridge, Marjo Tuomainen, Seppo Auriola, Arto Urtti
Currently, drug delivery to the posterior eye segment relies on intravitreal injections of therapeutics. This approach requires frequent injections and does not guarantee drug delivery to intracellular targets. Controlled release systems and nanoparticles are being investigated to mitigate these challenges but most of these approaches lack translational success to the clinics. In our present study, we report a peptide based delivery system that utilizes enzyme assisted cleavable linkers to release conjugated cargo within the retinal pigment epithelial (RPE) cells...
February 14, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28196624/corrigendum-to-diffusion-of-water-soluble-sorptive-drugs-in-hema-maa-hydrogels-j-control-release-239-october-10-2016-242-248
#11
D E Liu, T J Dursch, N O Taylor, S Y Chan, D T Bregante, C J Radke
No abstract text is available yet for this article.
February 10, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28192155/modality-of-tumor-endothelial-vegfr2-silencing-mediated-improvement-in-intratumoral-distribution-of-lipid-nanoparticles
#12
Shoshiro Yamamoto, Akari Kato, Yu Sakurai, Tomoya Hada, Hideyoshi Harashima
The vascular endothelial growth factor (VEGF)-mediated enhancement in vascular permeability is considered to be a major factor in tumor-targeting delivery via the enhanced permeability and retention (EPR) effect. We previously reported that the silencing of the endothelial VEGF receptor (VEGFR2) by a liposomal siRNA system (RGD-MEND) resulted in an enhanced intratumoral distribution of polyethylene glycol (PEG)-modified liposomes (LPs) in a renal cell carcinoma, a type of hypervascularized cancer, although the inhibition of VEGF signaling would be expected to decrease the permeability of the tumor vasculature...
February 10, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28192154/electrospun-polyurethane-nanofiber-scaffolds-with-ciprofloxacin-oligomer-effect-on-drug-release-and-cell-attachment-versus-free-drug
#13
Meghan Ee Wright, Ian C Parrag, Meilin Yang, J Paul Santerre
An electrospun degradable polycarbonate urethane (PCNU) nanofiber scaffold loaded with antibiotic was investigated in terms of antibacterial efficacy and cell compatibility for potential use in gingival tissue engineering. Antimicrobial oligomer (AO), a compound which consists of two molecules of ciprofloxacin (CF) covalently bound via hydrolysable linkages to triethylene glycol (TEG), was incorporated via a one-step blend electrospinning process using a single solvent system at 7 and 15% w/w equivalent CF with respect to the PCNU...
February 10, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28189628/perlecan-and-vascular-endothelial-growth-factor-encoding-dna-loaded-chitosan-scaffolds-promote-angiogenesis-and-wound-healing
#14
Megan S Lord, April L Ellis, Brooke L Farrugia, John M Whitelock, Hernan Grenett, Chuanyu Li, Robert L O'Grady, Arthur A DeCarlo
The repair of dermal wounds, particularly in the diabetic population, poses a significant healthcare burden. The impaired wound healing of diabetic wounds is attributed to low levels of endogenous growth factors, including vascular endothelial growth factor (VEGF), that normally stimulate multiple phases of wound healing. In this study, chitosan scaffolds were prepared via freeze drying and loaded with plasmid DNA encoding perlecan domain I and VEGF189 and analyzed in vivo for their ability to promote dermal wound healing...
February 9, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28189629/cell-mediated-delivery-of-synthetic-nano-and-microparticles
#15
Maxime Ayer, Harm-Anton Klok
Cell mediated delivery of synthetic nano- and microparticle based drug carriers is a very promising strategy to enhance control over the distribution of drugs and improve targeting. This article will present an overview of work, which has been done to explore cell surface modification strategies for the cellular hitchhiking of synthetic nano- and microparticles. The first part of this article will present and discuss the different types of cells that have been explored for cell mediated drug delivery. The second part of this review will discuss the various chemical strategies that have been elaborated for the conjugation or immobilization of nano- and microparticles on the surface of these cells...
February 8, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28188808/characterization-of-a-novel-intrinsically-radiopaque-drug-eluting-bead-for-image-guided-therapy-dc-bead-lumi%C3%A2
#16
Koorosh Ashrafi, Yiqing Tang, Hugh Britton, Orianne Domenge, Delphine Blino, Andrew J Bushby, Kseniya Shuturminska, Mark den Hartog, Alessandro Radaelli, Ayele H Negussie, Andrew S Mikhail, David L Woods, Venkatesh Krishnasamy, Elliot B Levy, Bradford J Wood, Sean L Willis, Matthew R Dreher, Andrew L Lewis
We have developed a straightforward and efficient method of introducing radiopacity into Polyvinyl alcohol (PVA)-2-Acrylamido-2-methylpropane sulfonic acid (AMPS) hydrogel beads (DC Bead™) that are currently used in the clinic to treat liver malignancies. Coupling of 2,3,5-triiodobenzaldehyde to the PVA backbone of pre-formed beads yields a uniformly distributed level of iodine attached throughout the bead structure (~150mg/mL) which is sufficient to be imaged under standard fluoroscopy and computed tomography (CT) imaging modalities used in treatment procedures (DC Bead LUMI™)...
February 8, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28185800/inhaled-sildenafil-as-an-alternative-to-oral-sildenafil-in-the-treatment-of-pulmonary-arterial-hypertension-pah
#17
Jahidur Rashid, Brijeshkumar Patel, Eva Nozik-Grayck, Ivan F McMurtry, Kurt R Stenmark, Fakhrul Ahsan
The practice of treating PAH patients with oral or intravenous sildenafil suffers from the limitations of short dosing intervals, peripheral vasodilation, unwanted side effects, and restricted use in pediatric patients. In this study, we sought to test the hypothesis that inhalable poly(lactic-co-glycolic acid) (PLGA) particles of sildenafil prolong the release of the drug,produce pulmonary specific vasodilation, reduce the systemic exposure of the drug, and may be used as an alternative to oral sildenafil in the treatment of PAH...
February 6, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28179196/ganglioside-inserted-into-pegylated-liposome-attenuates-anti-peg-immunity
#18
Yu Mima, Amr S Abu Lila, Taro Shimizu, Masami Ukawa, Hidenori Ando, Yasuko Kurata, Tatsuhiro Ishida
Despite the clinical introduction of a vast number of polyethylene glycol (PEG)-conjugated therapeutics, conjugated PEG is also known for an unfortunate inclination toward immunogenicity. Immunogenicity of PEG, manifested by the robust production of anti-PEG IgM, is known to compromise the therapeutic efficacy and/or reduce the tolerance of PEGylated therapeutics. In the present study, we inserted ganglioside into the membrane of PEGylated liposome (PL) to prepare ganglioside-modified PEGylated liposomes (G-PL), and investigated its efficacy in attenuating the anti-PEG IgM response against PL...
February 6, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28174100/a-traceless-reversible-polymeric-colistin-prodrug-to-combat-multidrug-resistant-mdr-gram-negative-bacteria
#19
Chongyu Zhu, Elena K Schneider, Jiping Wang, Kristian Kempe, Paul Wilson, Tony Velkov, Jian Li, Thomas P Davis, Michael R Whittaker, David M Haddleton
Colistin methanesulfonate (CMS) is the only prodrug of colistin available for clinical use for the treatment of infections caused by multidrug-resistant (MDR) Gram-negative bacteria. Owing to its slow and variable release, an alternative is urgently required to improve effectiveness. Herein we describe a PEGylated colistin prodrug whereby the PEG is attached via a cleavable linker (col-aaPEG) introducing an acetic acid terminated poly (ethylene glycol) methyl ether (aaPEG) onto the Thr residue of colistin. Due to the labile ester containing link, this prodrug is converted back into active colistin in vitro within 24h...
February 5, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28167287/poly-sgrna-sirna-ribonucleoprotein-nanoparticles-for-targeted-gene-disruption
#20
Jong Seong Ha, Jae Sung Lee, Jaepil Jeong, Hejin Kim, Juyoung Byun, Sang Ah Kim, Hee Jae Lee, Hak Suk Chung, Jong Bum Lee, Dae-Ro Ahn
Clustered regularly interspaced short palindromic repeats (CRISPR)-associated protein-9 nuclease (Cas9) can be used for the specific disruption of a target gene to permanently suppress the expression of the protein encoded by the target gene. Efficient delivery of the system to an intracellular target site should be achieved to utilize the tremendous potential of the genome-editing tool in biomedical applications such as the knock-out of disease-related genes and the correction of defect genes. Here, we devise polymeric CRISPR/Cas9 system based on poly-ribonucleoprotein (RNP) nanoparticles consisting of polymeric sgRNA, siRNA, and Cas9 endonuclease in order to improve the delivery efficiency...
February 4, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
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