journal
MENU ▼
Read by QxMD icon Read
search

Journal of Controlled Release: Official Journal of the Controlled Release Society

journal
https://www.readbyqxmd.com/read/30428307/modular-core-shell-polymeric-nanoparticles-mimicking-viral-structures-for-vaccination
#1
Bo Lou, Ans De Beucklaer, Eger Boonstra, Dandan Li, Bruno G De Geest, Stefaan De Koker, Enrico Mastrobattista, Wim E Hennink
Recent advances in the development of protein-based vaccines have expanded the opportunities for preventing and treating both infectious diseases as well as cancer. However, the development of readily and efficient antigen delivery systems capable of stimulating strong cytotoxic T-lymphocyte (CTL) responses remains a challenge. With the attempt to closely mimic the properties of viruses in terms of their size and molecular organization, we constructed RNA (which is a ligand for Toll-like receptor 7 (TLR7) and TLR8) and antigen-loaded nanoparticles resembling the structural organization of viruses...
November 11, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/30419268/single-bead-investigation-of-a-clinical-drug-delivery-system-a-novel-release-mechanism
#2
E Ahnfelt, J Gernandt, Y Al-Tikriti, E Sjögren, H Lennernäs, P Hansson
Microgels, such as polymeric hydrogels, are currently used as drug delivery devices (DDSs) for chemotherapeutics and/or unstable drugs. The clinical DDS DC bead® was studied with respect to loading and release, measured as relative bead-volume, of six amphiphilic molecules in a micropipette-assisted microscopy method. Theoretical models for loading and release was used to increase the mechanistic understanding of the DDS. It was shown that equilibrium loading was independent of amphiphile concentration. The loading model showed that the rate-determining step was diffusion of the molecule from the bulk to the bead surface ('film control')...
November 9, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/30419267/controlled-release-strategy-designed-for-intravitreal-protein-delivery-to-the-retina
#3
Vianney Delplace, Arturo Ortin-Martinez, En Leh S Tsai, Alan N Amin, Valerie Wallace, Molly S Shoichet
Therapeutic protein delivery directly to the eye is a promising strategy to treat retinal degeneration; yet, the high risks of local drug overdose and cataracts associated with bolus injection have limited progress, requiring the development of sustained protein delivery strategies. Since the vitreous humor itself is a gel, hydrogel-based release systems are a sensible solution for sustained intravitreal protein delivery. Using ciliary neurotrophic factor (CNTF) as a model protein for ocular treatment, we investigated the use of an intravitreal, affinity-based release system for protein delivery...
November 9, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/30415016/predicting-drug-delivery-efficiency-into-tumor-tissues-through-molecular-simulation-of-transport-in-complex-vascular-networks
#4
Evan P Troendle, Ayesha Khan, Peter C Searson, Martin B Ulmschneider
Efficient delivery of anticancer drugs into tumor tissues at maximally effective and minimally toxic concentrations is vital for therapeutic success. At present, no method exists that can predict the spatial and temporal distribution of drugs into a target tissue after administration of a specific dose. This prevents accurate estimation of optimal dosage regimens for cancer therapy. Here we present a new method that predicts quantitatively the time-dependent spatial distribution of drugs in tumor tissues at sub-micrometer resolution...
November 8, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/30415015/physical-blood-brain-barrier-disruption-induced-by-focused-ultrasound-does-not-overcome-the-transporter-mediated-efflux-of-erlotinib
#5
Sébastien Goutal, Matthieu Gerstenmayer, Sylvain Auvity, Fabien Caillé, Sébastien Mériaux, Irène Buvat, Benoit Larrat, Nicolas Tournier
Overcoming the efflux mediated by ATP-binding cassette (ABC) transporters at the blood-brain barrier (BBB) remainsss a challenge for the delivery of small molecule tyrosine kinase inhibitors (TKIs) such as erlotinib to the brain. Inhibition of ABCB1 and ABCG2 at the mouse BBB improved the BBB permeation of erlotinib but could not be achieved in humans. BBB disruption induced by focused ultrasound (FUS) was investigated as a strategy to overcome the efflux transport of erlotinib in vivo. In rats, FUS combined with microbubbles allowed for a large and spatially controlled disruption of the BBB in the left hemisphere...
November 8, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/30414464/clay-nanoparticles-co-deliver-three-antigens-to-promote-potent-immune-responses-against-pathogenic-escherichia-coli
#6
Weiyu Chen, Huali Zuo, Barbara Rolfe, Mark A Schembri, Rowland N Cobbold, Bing Zhang, Timothy J Mahony, Zhi Ping Xu
Currently, there are few strategies for controlling pathogenic bacteria, especially the pathotypes of Escherichia coli which are an emerging threat to public health worldwide. Here, multivalent vaccine formulations are reported for control of pathogenic E. coli. The formulations utilised clay nanoparticles, either layered double hydroxides (LDH) or hectorite (HEC), to complex with a cocktail of three recombinant antigens, intimin β (IB), proprietary antigen 1 (PAg1) and proprietary antigen 2 (PAg2). Acting as nano-adjuvants, LDH and HEC were able to stimulate strong, durable and balanced immune responses in mice...
November 7, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/30414463/glatiramer-acetate-persists-at-the-injection-site-and-draining-lymph-nodes-via-electrostatically-induced-aggregation
#7
Jimmy Y Song, Nicholas R Larson, Sharadvi Thati, Irma Torres-Vazquez, Noraida Martinez-Rivera, Natalia J Subelzu-Aispuru, Martin A Leon, Eduardo Rosa-Molinar, Christian Schöneich, C Russell Middaugh, Cory J Berkland
Glatiramer acetate (GA) is widely prescribed for the treatment of relapsing-remitting multiple sclerosis, however, the mechanism of action is still not fully understood. We investigated the structural properties of GA and examined alterations to the drug upon injection into the subcutaneous space. First, a variety of biophysical characterization techniques were employed to characterize GA in solution. GA was found to exist as alpha helices in solution with a hydrodynamic radius of ~3 nm in size. To simulate GA behavior at the site of injection, GA was injected into a solution of 1...
November 7, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/30408555/boosting-rnai-therapy-for-orthotopic-glioblastoma-with-nontoxic-brain-targeting-chimaeric-polymersomes
#8
Yanan Shi, Yu Jiang, Jinsong Cao, Weijing Yang, Jian Zhang, Fenghua Meng, Zhiyuan Zhong
Glioblastoma with intracranial infiltrative growth remains an incurable disease mainly owing to existence of blood brain barrier (BBB) and off-target drug toxicity. RNA interference (RNAi) with a high specificity and low toxicity emerges as a new treatment modality for glioblastoma. The clinical application of RNAi technology is, however, hampered by the absence of safe and brain-targeting transfection agents. Here, we report on angiopep-2 peptide-decorated chimaeric polymersomes (ANG-CP) as a nontoxic and brain-targeting non-viral vector to boost the RNAi therapy for human glioblastoma in vivo...
November 5, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/30408554/peptide-based-targeted-therapeutics-focus-on-cancer-treatment
#9
REVIEW
Fatemeh Araste, Khalil Abnous, Maryam Hashemi, Seyed Mohmmad Taghdisi, Mohammad Ramezani, Mona Alibolandi
Therapeutic peptides are attracting increasing attention for biomedical applications. Peptides present promising opportunities in targeted drug delivery due to their high specificity, selectivity, small dimensions, ease of modification, and high biocompatibility. During the last decade, the potential of peptides as therapeutics or targeting ligands has been boomed in nanotechnology and cancer research. This review summarizes various peptides as therapeutics and targeting ligands in cancer therapy. At first, two categories of tumor homing and cell penetrating peptides (CPPs) are introduced and then we will discuss the modification of CPPs...
November 5, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/30408553/relationship-between-amorphous-solid-dispersion-in-vivo-absorption-and-in-vitro-dissolution-phase-behavior-during-dissolution-speciation-and-membrane-mass-transport
#10
Venecia Wilson, Xiaochun Lou, Donald J Osterling, Deanne F Stolarik, Gary Jenkins, Wenqing Gao, Geoff G Z Zhang, Lynne S Taylor
Enzalutamide is a fast crystallizing, hydrophobic compound that has solubility limited absorption in vivo. Given the low aqueous solubility of this compound, it was of interest to evaluate amorphous formulations in vitro and in vivo. Amorphous solid dispersions (ASD) of enzalutamide were prepared with the hydrophilic polymers, hydroxypropyl methylcellulose acetate succinate (HPMCAS) and copovidone (PVPVA). A side-by-side diffusion cell was developed as an in vitro characterization tool to discriminate enzalutamide ASDs based upon the solute thermodynamic activity achieved during dissolution and its impact on the subsequent membrane transport rates, phase behavior, and drug speciation...
November 5, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/30408552/the-origin-of-neural-stem-cells-impacts-their-interactions-with-targeted-lipid-nanocapsules-potential-role-of-plasma-membrane-lipid-composition-and-fluidity
#11
Dario Carradori, Andreia G Dos Santos, Julien Masquelier, Adrien Paquot, Patrick Saulnier, Joël Eyer, Véronique Préat, Giulio G Muccioli, Marie-Paule Mingeot-Leclercq, Anne des Rieux
The adsorption of a peptide (NFL-TBS.40-63 peptide (NFL)) known to induce neuronal stem cells (NSC) differentiation in vitro, at the surface of lipid nanocapsules (LNC) provides a targeting drug delivery system that penetrates subventricular zone-neural stem cells (SVZ-NSC) but not central canal-NSC (CC-NSC). We hypothesized preferential interactions could explaine, at least partially, the different properties of SVZ- and CC-NSC plasma membranes. The objective of this work was to compare SVZ- and CC-NSC plasma membrane lipid composition, fluidity and permeability...
November 5, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/30395897/design-formulation-and-evaluation-of-novel-dissolving-microarray-patches-containing-a-long-acting-rilpivirine-nanosuspension
#12
Maelíosa T C Mc Crudden, Eneko Larrañeta, Annie Clark, Courtney Jarrahian, Annie Rein-Weston, Sophie Lachau-Durand, Nico Niemeijer, Peter Williams, Clement Haeck, Helen O McCarthy, Darin Zehrung, Ryan F Donnelly
One means of combating the spread of human immunodeficiency virus (HIV) is through the delivery of long-acting, antiretroviral (ARV) drugs for prevention and treatment. The development of a discreet, self-administered and self-disabling delivery vehicle to deliver such ARV drugs could obviate compliance issues with daily oral regimens. Alternatives in development, such as long-acting intramuscular (IM) injections, require regular access to health care facilities and disposal facilities for sharps. Consequently, this proof of concept study was developed to evaluate the use of dissolving microarray patches (MAPs) containing a long-acting (LA) nanosuspension of the candidate ARV drug, rilpivirine (RPV)...
November 2, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/30391405/epirubicin-loaded-polymeric-micelles-effectively-treat-axillary-lymph-nodes-metastasis-of-breast-cancer-through-selective-accumulation-and-ph-triggered-drug-release
#13
Tsukasa Chida, Yutaka Miura, Horacio Cabral, Takahiro Nomoto, Kazunori Kataoka, Nobuhiro Nishiyama
Suppression of axillary lymph node metastasis (ALNM) is an important goal in the treatment of breast cancer. While several therapies directed to ALNM have been evaluated, effective and safe treatments for ALNM in triple negative breast cancer (TNBC) have not been established yet, especially against initial/small metastases. Here, we demonstrated the therapeutic effect of an anthracycline drug, epirubicin (EPI)-loaded polymeric micelles equipped with pH-triggered drug release property (EPI/m) against ALNM of TNBC...
November 2, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/30391316/ph-sensitive-morphological-transitions-in-polymeric-tadpole-assemblies-for-programmed-tumor-therapy
#14
Cunfeng Song, Tongtong Lin, Qiang Zhang, S Thayumanavan, Lei Ren
Ultrafine single-chain tadpole polymers (SCTPs), containing an intrachain crosslinked globule and a pH-sensitive linear polymer chain, have been synthesized. Self-assembly of these polymers depends on the linear block length and the pH, at which the polymer is assembled. Although the SCTPs themselves exhibit a size that is consistent with a single-chain species, the self-assembled SCTPs were found to be substantially larger. Since the transition between these two structures is reversibly dependent on pH, we explored the possibility of utilizing these assemblies to achieve deep tissue penetration in tumors...
October 31, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/30393183/co-delivery-of-sialox15-and-sunitinib-for-reversing-the-new-onset-of-type-1-diabetes-in-non-obese-diabetic-mice
#15
Yang Peng, Di Wen, Feng Lin, Ram I Mahato
Type 1 diabetes (T1D) is a chronic autoimmune disease caused by proinflammatory T cell infiltration associated cytokine secretion and reactive oxygen species (ROS) production. In this study, our objective was to determine whether co-delivery of sunitinib, a member of tyrosine kinase inhibitor (TKI) family, and siRNA against Alox15 (siAlox15) could reverse the new-onset of T1D in non-obese diabetic (NOD)/ShiLtJ female mice which spontaneously develop diabetes. A cationic copolymer methoxy poly(ethylene glycol)-block-poly(2-methyl-2-carboxyl-propylene carbonate-graft-dodecanol-graft-tetraethylenepentamine) (mPEG-b-PCC-g-DC-g-TEPA) was used to encapsulate sunitinib with 8...
October 26, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/30367922/synthetic-cannabinoids-nano-micelles-for-the-management-of-triple-negative-breast-cancer
#16
Khaled Greish, Aanchal Mathur, Reem Al Zahrani, Sara Elkaissi, Muna Al Jishi, Osama Nazzal, Safa Taha, Valeria Pittalà, Sebastien Taurin
Triple-negative breast cancer (TNBC) is a highly heterogeneous disease with poor prognosis and inadequate therapeutic outcome. This contribution reports the use of a cannabinoid derivative, WIN55,212-2 (WIN) on the growth of TNBC in a 4T1 syngeneic mouse model. To reduce the well-known psychoactive side effects of cannabinoids, we prepared a nanomicellar formulation of WIN (SMA-WIN). In vivo biodistribution, in silico ADME predictions, anticancer activity, and psychoactive effect of WIN and SMA-WIN studies suggest that SMA-WIN formulation can reduce to greater extent tumor growth with milder psychoactive side effects when compared to free drug...
October 25, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/30367921/bifunctional-peptide-hybrids-targeting-the-matrix-of-mitochondria
#17
Annika Klimpel, Ines Neundorf
The mitochondrial organelle is associated with many diseases, including diabetes, age-related neuro-degenerative diseases and cancer. Therefore, the effective delivery of drug molecules to mitochondria became increasingly important during the past years. Within this work, we designed and analyzed bifunctional hybrid peptides comprised of a mitochondrial targeting sequence (MTS) attached to a cell-penetrating peptide (CPP). Our results demonstrate that choice of the MTS must be carefully undertaken, since not every MTS that was selected was comparably capable to target mitochondria...
October 24, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/30365993/anionic-1-2-distearoyl-sn-glycero-3-phosphoglycerol-dspg-liposomes-induce-antigen-specific-regulatory-t-cells-and-prevent-atherosclerosis-in-mice
#18
Naomi Benne, Janine van Duijn, Fernando Lozano Vigario, Romain J T Leboux, Peter van Veelen, Johan Kuiper, Wim Jiskoot, Bram Slütter
Atherosclerosis is the predominant underlying pathology of many types of cardiovascular disease and is one of the leading causes of death worldwide. It is characterized by the retention of oxidized low-density lipoprotein (ox-LDL) in lipid-rich macrophages (foam cells) in the intima of arteries. Autoantigens derived from oxLDL can be used to vaccinate against atherosclerosis. However, a major challenge is the induction of antigen-specific Tregs in a safe and effective way. Here we report that liposomes containing the anionic phospholipid 1,2-distearoyl-sn-glycero-3-phosphoglycerol (DSPG) induce Tregs that are specific for the liposomes' cargo...
October 23, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/30359667/the-impact-of-digestion-is-essential-to-the-understanding-of-milk-as-a-drug-delivery-system-for-poorly-water-soluble-drugs
#19
Ben J Boyd, Malinda Salim, Andrew J Clulow, Gisela Ramirez, Anna C Pham, Adrian Hawley
Milk has previously been considered as a potential lipid-based drug delivery system for poorly water soluble drugs but it has never gained significant attention. This is in part because relying on solubility in lipid-based formulations (in this case milk) does not provide a complete picture of the behavior of such systems upon digestion. Herein, we demonstrate using time resolved X-ray scattering that the digestion of milk is actually crucial to the solubilisation of a poorly water-soluble drug, halofantrine...
October 23, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/30359668/a-novel-elastin-like-polypeptide-drug-carrier-for-cyclosporine-a-improves-tear-flow-in-a-mouse-model-of-sj%C3%A3-gren-s-syndrome
#20
Hao Guo, Changrim Lee, Mihir Shah, Srikanth R Janga, Maria C Edman, Wannita Klinngam, Sarah F Hamm-Alvarez, J Andrew Mackay
As a potent macrolide immunosuppressant, cyclosporine A (CsA) is used to treat multiple autoimmune diseases, including non-autoimmune and autoimmune-mediated dry eye disease, rheumatoid arthritis and psoriasis. Despite its potency, CsA has poor solubility, poor bioavailability, and can cause serious adverse reactions such as nephrotoxicity and neurotoxicity. To overcome these limitations, we invented a new strategy to carry CsA by fusing its cognate human receptor, cyclophilin A (CypA), to a 73 kDa elastin-like polypeptide (ELP) termed A192 using recombinant protein expression...
October 22, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
journal
journal
29304
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"