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Journal of Child Neurology

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https://www.readbyqxmd.com/read/29877131/onabotulinumtoxin-a-botox%C3%A2-for-prophylactic-treatment-of-pediatric-migraine-a-retrospective-longitudinal-analysis
#1
Shalini Shah, Michael-David Calderon, Wei Der Wu, Jihan Grant, Joseph Rinehart
BACKGROUND: The use of onabotulinumtoxin A in the pediatric population has not been evaluated for chronic migraine in a longitudinal study. This retrospective study sought to determine the efficacy and safety of onabotulinumtoxin A in prophylactic treatment of chronic migraine in the pediatric population. METHODS: The authors retrospectively evaluated pediatric patients who had been treated with onabotulinumtoxin A in the outpatient pain clinic for chronic migraine...
August 2018: Journal of Child Neurology
https://www.readbyqxmd.com/read/29862897/incidence-of-childhood-epilepsy-in-estonia
#2
Kadi Veri, Inga Talvik, Ulvi Vaher, Aita Napa, Pilvi Ilves, Oivi Uibo, Eve Õiglane-Shlik, Rael Laugesaar, Reet Rein, Anneli Kolk, Klari Noormets, Tiia Reimand, Katrin Õunap, Tiina Talvik
The aim of this prospective epidemiological study was to establish the incidence rate of childhood epilepsy in Estonia, to describe the clinical spectrum and to identify etiology of childhood epilepsy. The overall incidence rate was 86.3/100 000. The incidence rate was the highest (141.9/100 000) in the age group from 5 to 9 years. Specific electroclinical syndromes were identified in 22.8% of cases. Structural or metabolic etiology was identified in 20.0% of cases, presumed genetic origin was identified in 33...
August 2018: Journal of Child Neurology
https://www.readbyqxmd.com/read/29886817/it-s-time-to-remember-hippocrates
#3
Jay Desai, Kiarash Sadrieh
No abstract text is available yet for this article.
July 2018: Journal of Child Neurology
https://www.readbyqxmd.com/read/29759004/is-there-a-delay-in-diagnosis-of-duchenne-muscular-dystrophy-among-preterm-born-males
#4
Aida Soim, Michael G Smith, Jennifer M Kwon, Joshua R Mann, Shiny Thomas, Emma Ciafaloni
The objective of this study was to investigate whether males who were born preterm took longer to receive a Duchenne muscular dystrophy diagnosis than term males. Data for males with Duchenne muscular dystrophy identified through a population-based surveillance system were analyzed using a Kaplan-Meier estimator. The first signs and symptoms were noted at a median age of 2 years in both groups. Median age when first signs and symptoms prompted medical evaluation was 2.59 years among preterm and 4.01 years among term males...
July 2018: Journal of Child Neurology
https://www.readbyqxmd.com/read/29756499/machine-learning-for-outcome-prediction-in-electroencephalograph-eeg-monitored-children-in-the-intensive-care-unit
#5
Iván Sánchez Fernández, Arnold J Sansevere, Marina Gaínza-Lein, Kush Kapur, Tobias Loddenkemper
The aim of this study was to evaluate the performance of models predicting in-hospital mortality in critically ill children undergoing continuous electroencephalography (cEEG) in the intensive care unit (ICU). We evaluated the performance of machine learning algorithms for predicting mortality in a database of 414 critically ill children undergoing cEEG in the ICU. The area under the receiver operating characteristic curve (AUC) in the test subset was highest for stepwise selection/elimination models (AUC = 0...
July 2018: Journal of Child Neurology
https://www.readbyqxmd.com/read/29724126/serial-analysis-of-multiple-serum-cytokine-responses-to-adrenocorticotropic-hormone-therapy-in-patients-with-west-syndrome
#6
Gaku Yamanaka, Natsumi Morishita, Shinichiro Morichi, Mika Takeshita, Urabe Tomomi, Yu Ishida, Takamatsu Tomoko, Shingo Oana, Yusuke Watanabe, Soken Go, Yasuyo Kashiwagi, Hisashi Kawashima
Adrenocorticotropic hormone (ACTH) therapy is effective for West syndrome; however, the underlying mechanism of action remains unknown. This study explored this mechanism in 5 Japanese patients with West syndrome, injected with ACTH for 28 days. Serum samples were obtained before and 30, 120, and 720 minutes after ACTH injection divided into an "early" (1-4 days) and a "late" (10-28 days) group. Responses to ACTH over time were analyzed by measuring the levels of 27 cytokines. In the early group, serum levels of interleukins-5, -9, and -17, basic fibroblast growth factor, interferon (IFN-γ), IFN-γ-inducible protein 10, chemokine ligand (CCL) 3 and 4, and platelet-derived growth factor were higher in all patients before ACTH administration than in the 720-minute time point...
July 2018: Journal of Child Neurology
https://www.readbyqxmd.com/read/29724124/how-do-biological-characteristics-of-primary-intracranial-tumors-affect-their-clinical-presentation-in-children-and-young-adults
#7
Thomas P C Chu, Anjali Shah, David Walker, Michel P Coleman
We demonstrated the pattern in presentation of primary intracranial tumors in a population-based cohort of patients aged 0-24 years identified from the National Cancer Registry for England, using linked medical records from primary care and hospitals. We used generalized additive models to estimate temporal changes in presentation rates. Borderline and malignant tumors presented at a similar rate in primary care (6.4 and 6.6 consultations per 100 patients each month) and in hospital (3.4 and 3.6). Benign tumors presented earlier but less frequently (rate = 4...
July 2018: Journal of Child Neurology
https://www.readbyqxmd.com/read/29714107/intermittent-esotropia-in-4-patients-with-allan-herndon-dudley-syndrome
#8
Cole J Swiston, David L Nash
Allan-Herndon-Dudley syndrome is a rare X-linked neurologic condition caused by mutations in monocarboxylate transporter 8 ( MCT8), which leads to deficient thyroid hormone transport. Typical features include severe cognitive impairment, truncal hypotonia, spastic paraplegia, weakness, and speech difficulties. Minimal literature exists describing the ocular findings in patients with Allan-Herndon-Dudley syndrome. We describe 4 male siblings affected with Allan-Herndon-Dudley syndrome with a novel nonsense mutation (Q90X) in the MCT8 protein...
July 2018: Journal of Child Neurology
https://www.readbyqxmd.com/read/29714095/impact-of-obesity-on-fosphenytoin-volume-of-distribution-in-pediatric-patients
#9
Ashley B Prusakov, Anup D Patel, Justin W Cole
The impact of body habitus on fosphenytoin pharmacokinetics is poorly understood in pediatric patients. This retrospective, single-center review examined differences in fosphenytoin volume of distribution (VD ) between children with normal and obese body habitus. From 2013 to 2015, patients 2 to 18 years of age who received a loading dose of fosphenytoin were identified. Thirty-seven patients met inclusion criteria. Mean total serum phenytoin concentration was 25.3 ± 6.5 μg/mL in the nonobese group and 29...
July 2018: Journal of Child Neurology
https://www.readbyqxmd.com/read/29714093/reply-to-letter-on-stroke-after-minor-head-trauma-in-infants-and-young-children-with-basal-ganglia-calcification-a-lenticulostriate-vasculopathy
#10
Jatinder Singh Goraya, Shivankshi Berry
No abstract text is available yet for this article.
July 2018: Journal of Child Neurology
https://www.readbyqxmd.com/read/29714087/letter-to-the-editor-regarding-stroke-after-minor-head-trauma-in-infants-and-young-children-with-basal-ganglia-calcification-a-lenticulostriate-vasculopathy
#11
Chaw-Liang Chang, Nan-Chang Chiu
No abstract text is available yet for this article.
July 2018: Journal of Child Neurology
https://www.readbyqxmd.com/read/29697019/frontal-lobe-cavernous-malformations-in-pediatric-patients-clinical-features-and-surgical-outcomes
#12
Chengjun Wang, Meng Zhao, Jia Wang, Shuo Wang, Zhongli Jiang, Jizong Zhao
The purpose of this study is to investigate the clinical manifestations, surgical treatment, and neurologic outcomes of frontal lobe cavernous malformations in children. A retrospective analysis of 23 pediatric frontal lobe cavernous malformation patients who underwent surgical treatment in Beijing Tiantan Hospital was performed. The case series included 16 boys and 7 girls. Gross total removal without surgical mortality was achieved in all patients. The mean follow-up period after surgery was 33.1 months. Two patients who left hospital with motor deficits gradually recovered after rehabilitative treatment, and other patients were considered to be in excellent clinical condition...
July 2018: Journal of Child Neurology
https://www.readbyqxmd.com/read/29687739/vigabatrin-for-epileptic-spasms-and-tonic-seizures-in-tuberous-sclerosis-complex
#13
Emma A van der Poest Clement, Mustafa Sahin, Jurriaan M Peters
Vigabatrin is recommended as first-line treatment for infantile spasms in tuberous sclerosis complex (TSC), but other indications in children with tuberous sclerosis complex are less known. We retrospectively reviewed 201 children with tuberous sclerosis complex, and identified 21 children older than 1 year started on vigabatrin for any indication and with sufficient follow-up data. The indication for vigabatrin was epileptic spasms (n = 13), tonic seizures (n = 5), both (n = 2), and status epilepticus (n = 1)...
July 2018: Journal of Child Neurology
https://www.readbyqxmd.com/read/29687752/electrocardiographic-evaluation-in-patients-with-spinal-muscular-atrophy-a-case-control-study
#14
Raffaele Falsaperla, Giovanna Vitaliti, Ausilia Desiree Collotta, Chiara Fiorillo, Alfredo Pulvirenti, Salvatore Alaimo, Catia Romano, Martino Ruggieri
BACKGROUND: This study aimed to show the impairment of autonomic cardiac conduction causing bradycardia and/or electrocardiographic alterations in children affected by spinal muscular atrophy type 1 and 2 (SMA 1 and 2). METHODS: We included 25 spinal muscular atrophy patients, admitted from November 2016 to May 2017. All patients underwent an electrocardiographic examination and we studied PR and QRS intervals, P-waves and QRS amplitudes, and heart rate in spinal muscular atrophy patients compared to a control group...
June 2018: Journal of Child Neurology
https://www.readbyqxmd.com/read/29687740/long-term-cognitive-outcome-of-children-with-parenchymal-neurocysticercosis-a-prospective-observation-study
#15
Pratibha Singhi, Prabhjot Malhi, Renu Suthar, Brijendra Deo, N K Khandelwal
To study the cognitive profile and scholastic performance of children with parenchymal neurocysticercosis. A total of 500 children with a diagnosis of neurocysticercosis and epilepsy registered in our pediatric neurocysticercosis clinic between January 1996 and December 2002 were enrolled. Patients were evaluated for their scholastic performance using their school grades. Cognitive assessment was done using Parental interview and the "Draw-a-Man" test. Poor scholastic performance was seen in 22.2% (111) children...
June 2018: Journal of Child Neurology
https://www.readbyqxmd.com/read/29687738/ganglioglioma-epilepsy-and-intellectual-impairment-due-to-familial-tsc1-deletion
#16
Tal Gilboa, Reeval Segel, Sharon Zeligson, Gheona Alterescu, Hilla Ben-Pazi
BACKGROUND: Tuberous sclerosis complex (TSC) is a multisystem disorder diagnosed by clinical criteria and/or genetic testing. Genetic testing reveals atypical phenotypes that have not met clinical criteria, with practical implications. METHODS: We describe 4 family members with pathogenic partial deletion in TSC1 who individually did not meet tuberous sclerosis complex clinical criteria. RESULTS: Family members had different and atypical findings of tuberous sclerosis complex...
June 2018: Journal of Child Neurology
https://www.readbyqxmd.com/read/29683017/retrospective-evaluation-of-changes-in-gait-patterns-in-children-and-adolescents-with-cerebral-palsy-after-multilevel-surgery
#17
Ramona Steppacher, David North, Christoph Künzle, Harald Lengnick, Harry Klima, Annegret Mündermann, Regina Wegener
The purpose of this study was to retrospectively investigate changes in gait patterns after single-event multilevel surgery in children and adolescents with bilateral cerebral palsy. Three-dimensional instrumented pre- and postoperative gait data of 12 patients were compared to data of 12 healthy control subjects using principal component analysis to reduce the dimensionality of kinematic and kinetic gait data and detect gait differences. The differences between pre- and postoperative data and between postoperative data and data of control subjects were calculated using a linear mixed model...
June 2018: Journal of Child Neurology
https://www.readbyqxmd.com/read/29673287/pediatric-stroke-rates-over-17-years-report-from-a-population-based-study
#18
Laura L Lehman, Jane C Khoury, J Michael Taylor, Samrat Yeramaneni, Heidi Sucharew, Kathleen Alwell, Charles J Moomaw, Katrina Peariso, Matthew Flaherty, Pooja Khatri, Joseph P Broderick, Brett M Kissela, Dawn O Kleindorfer
We previously published rates of pediatric stroke using our population-based Greater Cincinnati Northern Kentucky Stroke Study (GCNK) for periods July 1993-June 1994 and 1999. We report population-based rates from 2 additional study periods: 2005 and 2010. We identified all pediatric strokes for residents of the GCNK region that occurred in July 1, 1993-June 30, 1994, and calendar years 1999, 2005, and 2010. Stroke cases were ascertained by screening discharge ICD-9 codes, and verified by a physician. Pediatric stroke was defined as stroke in those <20 years of age...
June 2018: Journal of Child Neurology
https://www.readbyqxmd.com/read/29667530/effects-of-developmental-age-on-symptom-reporting-and-neurocognitive-performance-in-youth-after-sports-related-concussion-compared-to-control-athletes
#19
Donna L Murdaugh, Kim E Ono, Sarah O Morris, Thomas G Burns
There is increased necessity to focus research on school-aged athletes with sports-related concussion (SRC). This study assessed differences in symptom reporting and neurocognitive performance in youth athletes who sustained a sports-related concussion. A total of 1345 concussed and 3529 nonconcussed athletes (ages 8-21) completed the Immediate Post-concussive Assessment and Cognitive Testing (ImPACT). Analyses of covariance were conducted in order to assess differences in neurocognitive performance and symptom reporting between the sports-related concussion and control groups across age ranges...
June 2018: Journal of Child Neurology
https://www.readbyqxmd.com/read/29651891/use-of-vagus-nerve-stimulator-on-children-with-primary-generalized-epilepsy
#20
William P Welch, Bilal Sitwat, Yoshimi Sogawa
OBJECTIVE: To describe the response to vagus nerve stimulator (VNS) in otherwise neurotypical children with medically intractable primary generalized epilepsy. METHODS: Retrospective chart review of patients who underwent vagus nerve stimulator surgery between January 2011 and December 2015. RESULTS: Eleven patients were identified. Median follow-up duration was 2.5 years (1.2-8.4 years). Prior to vagus nerve stimulator surgery, all patients had at least 1 seizure per week, and 7/11 (64%) had daily seizures...
June 2018: Journal of Child Neurology
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