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Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire

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https://www.readbyqxmd.com/read/28915362/improved-efficacy-of-hyperthermia-by-auraptene-in-human-colon-adenocarcinoma-cells
#1
Mahdi Moussavi, Farhang Haddad, Matin Matin, Mehrdad Iranshahi, Fatemeh Rassouli
Colon adenocarcinoma is one of the most common cancers worldwide, and resistance to current therapeutic modalities is a serious drawback in its treatment. Auraptene is a natural coumarin with considerable anticancer effects. The goal of present study was to introduce a novel combinatorial approach against colon adenocarcinoma cells. To do so, HT29 cells were pretreated with non-toxic auraptene and then hyperthermia was applied. Afterwards, viability of cells was assessed, changes induced in the cell cycle were analyzed, and expression pattern of candidate genes was studied...
September 15, 2017: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/28915355/thiamin-deficiency-on-fetal-brain-development-with-and-without-prenatal-alcohol-exposure
#2
Olena Kloss, Michael Eskin, Miyoung Suh
Adequate thiamin levels are crucial for optimal health, through maintenance of homeostasis and viability of metabolic enzymes, which require thiamine as a co-factor. Thiamin deficiency occurs during pregnancy when dietary intake is inadequate or excessive alcohol is consumed. Thiamin deficiency leads to brain dysfunction due to its involvement in synthesis of myelin and neurotransmitters (eg. acetylcholine, γ-aminobutyric acid, glutamate), and increases oxidative stress by decreasing the production of reducing agents...
September 15, 2017: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/28892647/mir-96-targets-sox6-and-promotes-proliferation-migration-and-invasion-of-hepatocellular-carcinoma
#3
Zhengwei Li, Ying Wang
OBJECTIVE: Recent research suggested that microRNA 96 (miR-96) might function as an oncogene in several types of cancers. Therefore, this study determined to probe into the mechanism of miR-96 in hepatocellular carcinoma (HCC) cells. METHODS: HCC tissues and non-tumorous tissues, HCC cell lines and healthy cell lines were all involved in this study. Quantitative real-time PCR (qRT-PCR) and western blot were used to detect MiR-96 and SOX6 mRNA and protein expressions...
September 11, 2017: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/28837779/portal-vein-ligation-alters-coding-and-non-coding-gene-expression-in-rat-livers
#4
Bin Li, Yan Zhu, Lei Xie, Shuyang Hu, Shupeng Liu, Xiaoqing Jiang
Portal vein occlusion increases the resectability of initially unresectable HCC by inducing the hypertrophy of non-occluded liver lobes. However, the mechanisms of how portal vein occlusion induces hepatic hypertrophy remains unclear. cDNA microarray was used to identify gene expression signatures of ligated and non-ligated lobes at different time after PVL. Bioinformatics analysis found that ligated liver lobes (LLL) and non-ligated liver lobes (NLLL) displayed different gene expression profiles. And expression of both coding and non-coding RNA were also different at the different time in LLL or NLLL after PVL...
August 24, 2017: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/28834683/global-prevalence-of-alcohol-use-and-binge-drinking-during-pregnancy-and-fetal-alcohol-spectrum-disorder
#5
Svetlana Popova, Shannon Lange, Charlotte Probst, Gerrit Gmel, Jürgen Rehm
Alcohol use during pregnancy is an established cause of Fetal Alcohol Spectrum Disorder (FASD), with heavy drinking during pregnancy being explicitly linked to Fetal Alcohol Syndrome (FAS). The current paper presents recent estimates of the prevalence of: i) any amount of alcohol use during pregnancy, ii) one or more binge drinking episode(s) (four or more standard drinks on a single occasion) during pregnancy, iii) FAS, and iv) FASD among the general population globally and by World Health Organization region...
August 23, 2017: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/28817785/diving-into-the-world-of-alcohol-teratogenesis-a-review-of-zebrafish-models-of-fetal-alcohol-spectrum-disorders
#6
Yohaan Fernandes, Desirè M Buckley, Johann K Eberhart
Fetal alcohol spectrum disorders (FASD) refer to the entire suite of deleterious outcomes resulting from embryonic alcohol exposure. Along with other reviews in this edition, we provide insight into how animal models, specifically the zebrafish; have informed our understanding of FASD. We first provide a brief introduction to FASD. We discuss the zebrafish as a model organism and its strengths for alcohol research. We detail how zebrafish has been used to model some of the major defects present in FASD. These include behavioral defects, such as social behavior as well as learning and memory, and structural defects, disrupting organs such as the brain, sensory organs, heart and craniofacial skeleton...
August 17, 2017: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/28817784/hydrogen-peroxide-regulates-angiogenesis-related-factors-in-tumor-cells
#7
Ana Jerónimo, Gonçalo Rodrigues, Filipe Vilas-Boas, Gabriel G Martins, Ana Bagulho, Carla Real
Tumor angiogenesis is required for tumor development and growth and is regulated by several factors including reactive oxygen species (ROS). Hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) is a ROS with an important role in cell signaling but how H<sub>2</sub>O<sub>2</sub> regulates tumor angiogenesis is still poorly understood. We have xenografted tumor cells with altered levels of H<sub>2</sub>O<sub>2</sub> by catalase overexpression into zebrafish embryos to study redox-induced tumor neovascularization...
August 17, 2017: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/28806534/knockdown-of-snail-inhibits-epithelial-mesenchymal-transition-of-human-laryngeal-squamous-cell-carcinoma-hep-2-cells-through-vdr-signaling-pathway
#8
Xue Zhao, Dan Yu, Jingpu Yang, Kai Xue, Yan Liu, Chunshun Jin
It has been well-documented that Snail plays a decisive role in various tumors. However, the direct effect of Snail on laryngeal squamous cell carcinoma (LSCC) has not been elaborated. In this study, we firstly detected the expression of Snail in 14 samples of patients with LSCC and found that its content was high in cancer tissues compared with adjacent tissues. Then we established LSCC Hep-2 cells with Snail silencing and validated the knockdown efficiency by western blotting and real-time PCR. Results showed that silencing of Snail significantly inhibited the ability of adhesion, migration, and invasion of Hep-2 cells...
August 14, 2017: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/28796950/age-related-differences-in-neuropsychological-assessment-of-fetal-alcohol-spectrum-disorder-a-cross-sectional-study
#9
Nicole Taylor, Leah Enns
This cross-sectional study examined six key areas of neuropsychological functioning (cognitive, academic, attention, executive function, adaptive skills) comparing adolescents and school-age children with prenatal alcohol exposure (PAE). The aims were: (1) to examine which neuropsychological measures were predictive of an FASD diagnosis in adolescents and school-age children with PAE, and (2) to compare the neuropsychological performance of adolescents and children diagnosed with FASD. Hierarchical logistic regressions determined that the Full-Scale IQ, Verbal Comprehension and Perceptual Reasoning indices, basic reading and math skills, adaptive functioning at school, and components of executive functioning (dependent on age) improved the probability of an accurate FASD diagnosis in both groups: 9...
August 10, 2017: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/28796949/mecp2-and-ctcf-enhancing-the-cross-talk-of-silencers
#10
Juan Ausio, Philippe T Georgel
This paper provides a brief introductory review of the most recent advances in our knowledge about structural and functional aspects of two transcriptional regulators: the methyl-CpG protein binding 2 (MeCP2), a protein whose mutated forms are involved in Rett syndrome and CCCTC-binding factor (CTCF), a constitutive transcriptional insulator. This is followed by a description of the post-translational modifications (PTMs) affecting these two proteins and an analysis of their known interacting partners. A special emphasis is placed on the recent studies connecting these two proteins focusing on the still poorly understood potential structural and functional interactions between the two of them on the chromatin substrate...
August 10, 2017: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/28793200/fasd-folic-acid-and-formic-acid-an-unholy-alliance-in-the-alcohol-abusing-mother
#11
Bhushan M Kapur, Marta Baber
Alcohol consumption during pregnancy remains a significant cause of preventable birth defects and developmental disabilities, however, the mechanism of toxicity remains unclear. Methanol is present as a congener in many alcoholic beverages and is formed endogenously. Since ethanol is preferentially metabolized over methanol, it has been found in the sera and CSF of alcoholics. Toxicity resulting from methanol has been attributed to formic acid. Formic acid is present in significantly higher quantities in biofluids of alcoholic patients...
August 9, 2017: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/28763625/microrna-1-3p-inhibits-proliferation-and-migration-of-oral-squamous-cell-carcinoma-cells-by-targeting-dkk1
#12
Zhenshi Wang, Jiaolong Wang, Zhihua Chen, Kun Wang, Lianshui Shi
We aimed to investigate the functional role and mechanism of miR-1-3p and DKK1 in oral squamous cell carcinoma (OSCC) cells. The level of miR-1-3p and DKK1 expression were detected in OSCC tissues and cells using RT-qPCR and Western blot. Dual luciferase reporter gene assay was applied to confirm the targeting relationship between miR-1-3p and DKK1. Functional assays, including MTT, Transwell, colony formation and flow cytometric analysis, were conducted to verify their effect on cell progressions. MTT, colony formation and Transwell assay indicated that proliferation, migration and invasion of SCC-4 cells was impaired with high miR-1-3p expression but promoted with high DKK1 expression...
August 1, 2017: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/28746817/human-bone-marrow-mesenchymal-stem-cells-bmscs-suppress-hepatic-stellate-cells-hscs-proliferation-by-inhibiting-the-ubiquitylation-of-p27
#13
Liang Wang, Guang Bai, Fei Chen
Bone marrow mesenchymal stem cells (BMSCs) have considerable therapeutic potential for the treatment of end-stage liver disease. Previous studies have demonstrated that BMSCs secreted growth factors and cytokines to inactivate hepatic stellate cells (HSCs), which inhibited the progression of hepatic fibrosis. The aim of this study was to determine the mechanism by which BMSCs suppress the function of HSCs in fibrosis. Our results showed that co-culture of BMSCs and HSCs induced cell cycle arrest at the G10/G1 phase and cell apoptosis of HSCs, which finally inhibited the cell proliferation of HSCs...
July 26, 2017: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/28746809/fetal-alcohol-spectrum-disorder-diagnosis-current-practices-and-future-considerations
#14
Albert Chudley
This paper discusses the current state of knowledge and practice of Fetal Alcohol Spectrum Disorder (FASD) diagnosis. The strengths and challenges of different models of diagnosis are compared. Some models require a team approach for evaluation, while other approaches assume that a clinician in his or her office provide a diagnosis based on a review of the patient's medical and social history, behaviour and physical examination. The author reviews the emergence of new information from recent advances in genetics, imaging and electrophysiology that have potential to lead to changes in practice and improved reliability of an FASD diagnosis...
July 26, 2017: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/28708947/kv10-1-potassium-channel-from-the-brain-to-the-tumors
#15
Verna Cázares-Ordoñez, Luis A Pardo
<i>KCNH1</i> gene encodes the Kv10.1 (Eag1) ion channel, a member of the EAG (ether-à-go-go) family of voltage-gated potassium channels. Recent studies have demonstrated that <i>KCHN1</i> mutations are implicated in Temple-Baraitser and Zimmermann-Laband syndromes and other forms of developmental deficits that all present with mental retardation and epilepsy, suggesting that Kv10.1 might be important for cognitive development in human. Although Kv10.1 channel is mainly expressed in the mammalian brain, its ectopic expression occurs in 70% of human cancers...
July 14, 2017: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/28708941/regulation-of-the-insulin-akt-signaling-pathway-and-glycolysis-during-dehydration-stress-in-the-african-clawed-frog-xenopus-laevis
#16
Cheng-Wei Wu, Shannon N Tessier, Kenneth B Storey
Estivation is an adaptive stress response utilized by some amphibians during periods of drought in the summer season. In this study, we examine the regulation of the insulin signaling cascade and glycolysis pathway in the African clawed frog Xenopus laevis during dehydration stress induced state of estivation. We show that in the brain and heart of X. laevis, dehydration reduces the phosphorylation of the insulin growth factor-1 receptor (IGF-1R), and this is followed by similar reductions in the phosphorylation of the Akt and mechanistic target of rapamycin (mTOR) kinase...
July 14, 2017: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/28700834/petroleum-ether-extract-of-njavara-rice-bran-upregulates-jak2-stat3-mediated-anti-inflammatory-profile-in-macrophages-and-aortic-endothelial-cells-promoting-regression-of-atherosclerosis
#17
Chithra K Pushpan, Jayalekshmy Ananthasankaran, Helen Antony
"Njavara"(Oryza sativa Linn) is a unique rice variety grown in Kerala that is reported to have significantly higher antioxidant, anti-inflammatory, chemical indices, and bioactive components compared with staple rice varieties. However, the role of NBE in reversing the atherosclerosis development remains unclear. The present study aimed to elucidate the role of Njavara rice bran petroleum ether extract (NBE) in promoting atherosclerotic regression. Male New Zealand white breed rabbits were divided into three groups...
July 12, 2017: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/28686845/metabolomics-and-fetal-alcohol-spectrum-disorder-a-mini-review
#18
Erin Goldberg, Michel Aliani
Fetal alcohol spectrum disorder (FASD) is a major public health issue that encompasses an array of physical, neurological and behavioral effects due to alcohol consumption during pregnancy. Classical biomarkers of FASD that are currently used lack sensitivity and specificity, and as such there is an opportunity through the use of novel metabolomics analysis to identify novel biomarkers to identify those at risk for FASD, which could more effectively aid in early intervention. The focus of this mini-review is to identify current work that has been done in the field of metabolomics in FASD in utero, and to highlight promising metabolites that could act as biomarkers in the future...
July 7, 2017: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/28662337/danshen-attenuates-osteoarthritis-related-cartilage-degeneration-through-inhibition-of-nf-%C3%AE%C2%BAb-signaling-pathway-in-vivo-and-in-vitro
#19
Xilin Xu, Hang Lv, Xiaodong Li, Hui Su, Xiaofeng Zhang, Jun Yang
Danshen is a traditional Chinese medicine herb that can alleviate osteoarthritis (Soder et al.) symptoms in animals. However, the underlying mechanisms remain poorly understood and require further investigation. In this study, rabbits with experimental OA were given intra-articular injection of Danshen (0.7 mL/day) for five weeks. In addition to attenuating the cartilage degeneration of OA rabbits, Danshen decreased the expression and activity of matrix metalloproteinase 9 (MMP-9) and MMP-13, whereas increased that of their natural inhibitors, tissue inhibitor of matrix metalloproteinase 1 (TIMP-1) and TIMP-2...
June 29, 2017: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/28658581/modulation-of-procaspase-7-self-activation-by-pest-amino-acid-residues-of-the-n-terminal-prodomain-and-intersubunit-linker
#20
Juliano Alves, Humberto Miguel Garay-Malpartida, João Marcelo Occhiucci, Jose Belizario
Procaspase-7 zymogen polypeptide is formed by a short prodomain, a large subunit (p20) and a small subunit (p10) connected to an intersubunit linker. Caspase-7 is activated by an initiator caspase -8 and -9 or by autocatalysis after specific cleavage at IQAD198↓S located at intersubunit linker. Previously, we identified that PEST regions made of amino acid residues Pro (P), Glu (E), Asp (D), Ser (S), Thr (T), Asn (N) and Gln (Q) are conserved flanking amino acid residues in the cleavage sites within at prodomain and intersubunit linker of all caspase family members...
June 28, 2017: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
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