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Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire

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https://www.readbyqxmd.com/read/30624963/fisetin-a-potential-caloric-restriction-mimetic-attenuates-senescence-biomarkers-in-rat-erythrocytes
#1
Sandeep Singh, Geetika Garg, Abhishek Kumar Singh, Akalabya Bissoyi, Syed Ibrahim Rizvi
An imbalanced redox status is a hallmark of the aging process. Caloric restriction mimetics (CRMs) are compounds that produce caloric restriction benefits at molecular, cellular and physiological levels translating into health-promoting effects. Fisetin is the least explored CRM and its role in modulation of oxidative stress during aging is not clearly known. The present study aims to investigate the anti-oxidative and protective potential of fisetin in D-galactose (D-gal)-induced accelerated senescence model rat and in naturally aged rat erythrocytes...
January 9, 2019: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/30620620/fkbp25-participates-in-dna-double-strand-break-repair
#2
David Dilworth, Fade Gong, Kyle M Miller, Christopher J Nelson
FK506-binding proteins (FKBPs) alter the conformation of proteins via cis-trans isomerization of prolyl peptide bonds. While this activity can be demonstrated in vitro, the intractability of detecting prolyl isomerization events in cells has limited our understanding of the biological processes regulated by FKBPs. Here we report that FKBP25 is an active participant in the repair of DNA double-strand breaks (DSBs). FKBP25 influences DSB repair pathway choice by promoting homologous recombination (HR) and suppressing single-strand annealing (SSA)...
January 8, 2019: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/30620618/knockdown-of-the-small-heat-shock-protein-p26-by-rna-interference-modifies-the-diapause-proteome-of-artemia-franciscana
#3
Hajer Malitan, Alejandro M Cohen, Thomas H MacRae
Embryos of the crustacean, Artemia franciscana may arrest as gastrulae, forming cysts that enter diapause, a state of reduced metabolism and enhanced stress tolerance. Diapausing cysts survive physiological stresses for years, due in part to molecular chaperones. p26, a small heat shock protein, is an abundant diapause-specific molecular chaperone in cysts and it affects embryo development and stress tolerance. p26 is therefore thought to influence many proteins in cysts and this study was undertaken to determine how the loss of p26 by RNA interference (RNAi) affects the diapause proteome of A...
January 8, 2019: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/30608867/cytoskeletal-control-of-nuclear-morphology-and-stiffness-are-required-for-opn-induced-bone-marrow-derived-mesenchymal-stem-cell-migration
#4
Lingling Liu, Qing Luo, Jinghui Sun, Guanbin Song
During cell migration, the movement of the nucleus must be coordinated with the cytoskeletal dynamics that influence the efficiency of cell migration. Our previous study demonstrated that osteopontin (OPN) significantly promotes the migration of bone marrow-derived mesenchymal stem cells (BMSCs). However, the mechanism of regulation of nuclear mechanics by the cytoskeleton during OPN-promoted BMSC migration remains unclear. In the present study, we investigated how the actin cytoskeleton influences nuclear mechanics in BMSCs...
January 4, 2019: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/30605366/ziziphus-spina-christi-leaves-methanolic-extract-alleviates-diethylnitrosamine-induced-hepatocellular-carcinoma-in-rats
#5
Manar Salah El-Din, AlShaimaa Mohamed Taha, Ahmed Abdel-Aziz Sayed, Ahmed Mohamed Salem
The present study aimed to evaluate the antitumor activity of Ziziphus spina-christi leaves extract (ZSCL) against diethylnitrosamine (DENA)-induced hepatocarcinogenesis in rats. The phytochemical constituents, in vitro antioxidant and cytotoxic activities of ZSCL extract were investigated. Male Wistar rats were divided into 6 groups: normal control, ZSCL1-administered rats (100 mg/ Kg body weight "b.w."), ZSCL2-administered rats (300 mg/ Kg b.w.), DENA-induced hepatocarcinogenesis, hepatocarcinogenesis-bearing rats treated either with ZSCL1 or ZSCL2...
January 3, 2019: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/30605356/fetal-alcohol-spectrum-disorder-fasd-affects-the-hippocampal-levels-of-histone-variant-h2a-z-2
#6
Taylor L Gretzinger, Monica Tyagi, Christine J Fontaine, Manjinder S Cheema, María González-Perez, Melissa E Freeman, Brian R Christie, Juan Ausio
Fetal Alcohol Spectrum disorder (FASD) is caused by the prenatal exposure to ethanol and has been linked to neurodevelopmental impairments. Alcohol has the potential to alter some of the epigenetic components which play a critical role during development. Previous studies have provided evidence that prenatal ethanol exposure results in abnormal epigenetic patterns (i.e. hypomethylation) of the genome. The aim of this study was to determine how prenatal exposure to ethanol in rats affects the hippocampal levels of expression of two important brain epigenetic transcriptional regulators involved in synaptic plasticity and memory consolidation: methyl CpG-binding protein 2 (MeCP2) and histone variant H2A...
January 3, 2019: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/30571142/microrna-34a-attenuates-vegf-mediated-retinal-angiogenesis-via-targeting-the-notch1
#7
Shaoyang Shi, Yong Jin, Haishan Song, Xiaolong Chen
Pathological angiogenesis in retina is main pathogenesis of ocular diseases closely associated with vision loss. Present work aimed to investigate effects of microRNA-34a (miR-34a) and its potential target Notch1 on retinal angiogenesis. For this objective, we employed oxygen-induced retinopathy (OIR) rats and human retinal microvascular endothelial cells (HRMECs) stimulated with vascular endothelial growth factors (VEGF). H&E staining, western blot for VEGF and immunofluorescence staining for CD31 were performed to verify establishment of OIR model...
December 20, 2018: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/30557035/gbp1-exerts-inhibitory-effects-on-acute-viral-myocarditis-through-the-inhibition-of-inflammatory-response-of-macrophage-in-mice
#8
Ya-Nan Zhao, Guang-Jun Xu, Ping Yang
Viral myocarditis (VMC) is a condition that could potentially progress to dilated cardiomyopathy or congestive heart failure, making it the leading cause of the untimely death in young adults. Interferon-induced GBP1 encodes much GTPase induced by interferon gamma in many eukaryotic cells. However, there is little known regarding the effect of GBP1 on acute VMC (AVMC). Hence, this study is aimed to assess the effect of GBP1 on AVMC. Once the AVMC mouse models were established, the functional role of GBP1 was determined in AVMC...
December 17, 2018: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/30532986/steroid-receptor-coactivator-1-regulates-glioma-angiogenesis-through-polyomavirus-enhancer-activator-3-signaling
#9
Yi Zhang, Wei Shi
Steroid receptor coactivator 1 (SRC-1) is a transcriptional coactivator for steroid receptors and other transcription factors. SRC-1 has been shown to play an important role in the progression of breast cancer and prostate cancer. However, its role in glioma progression remains unknown. Here, in this study, we reported that SRC-1 is upregulated in the vessels of human glioma and exerts important regulatory functions. Specifically, SRC-1 expression significantly enhanced bFGF-mediated angiogenesis in vivo. Downregulating of SRC-1 expression suppressed endothelial cell migration and tube formation in vitro and upregulated the expression of pro-angiogenic factors including VEGF and MMP-9 in glioma cells...
December 11, 2018: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/30508384/carboxypeptidase-e-%C3%AE-n-promotes-migration-invasion-and-epithelial-mesenchymal-transition-of-human-osteosarcoma-cell-lines-through-the-wnt-%C3%AE-catenin-pathway
#10
Shuli Fan, Xiang Gao, Peng Chen, Xu Li
Osteosarcoma (OS) is the most common malignant bone tumor in children and adolescents, and metastatic OS is the major cause of OS-related death. Carboxypeptidase E (CPE) is demonstrated to be highly expressed in some cancer types, and its N-terminal truncated form, CPE-ΔN, is implicated in tumor metastasis and poor prognosis. In this study, we investigated the effect of CPE-ΔN on cell migration, invasion and epithelial-mesenchymal transition (EMT) of OS cells, and illustrated the molecular mechanisms. We first constructed CPE-ΔN overexpressing human OS cell lines (143B and U2OS cells), and found that ectopic CPE-ΔN expression in OS cells enhanced cellular migratory and invasiveness abilities, and promoted EMT process...
December 3, 2018: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/30481061/vitamin-e-supplementation-and-caloric-restriction-promotes-regulation-of-insulin-secretion-and-glycemic-homeostasis-by-different-mechanisms-in-rats
#11
Paula R Venturini, Bruna Fontana Thomazini, Camila Andréa Oliveira, Armindo A Alves, Thaís Furtado Camargo, Caio E C Domingues, Helena C L Barbosa-Sampaio, Maria Esméria C do Amaral
Vitamin E and caloric restriction have antioxidant effects in mammals. The aim of this study was to evaluate effects of vitamin E supplementation and caloric restriction upon insulin secretion and glucose homeostasis in rats. Male Wistar rats were distributed among the following groups: C, control group fed ad libitum; R, food quantity reduction of 40%; CV, control group supplemented with vitamin E [30 mg·kg-1 ·day-1 ]; and RV, food-restricted group supplemented with vitamin E. The experiments ran for 21 days...
November 27, 2018: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/30481052/mir-3666-inhibits-lung-cancer-cell-proliferation-migration-and-invasion-by-targeting-bptf
#12
Linqing Pan, Zhipeng Tang, Lina Pan, Ranran Tang
Our previous study suggested that BPTF overexpression was observed in lung adenocarcinoma, and closely associated with advanced clinical stage, more metastatic lymph nodes, present distant metastasis, low histological grade and poor prognosis. Down-regulation of BPTF inhibited lung adenocarcinoma cells proliferation and promoted lung adenocarcinoma cells apoptosis. The purpose of this study is to identify valuable microRNAs (miRNAs), which target BPTF to modulate lung adenocarcinoma cells proliferation. In our results, we found that miR-3666 was notably reduced in lung adenocarcinoma tissues and cell lines...
November 27, 2018: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/30475650/ginsenoside-metabolite-compound-k-induces-apoptosis-and-autophagy-in-non-small-cell-lung-cancer-cells-via-ampk-mtor-and-jnk-pathways
#13
Chen Li, Yuchao Dong, Libo Wang, Gongbin Xu, Qing Yang, Xiaofei Tang, Yingying Qiao, Zhonghuang Cong
Compound K (C-K, 20-O-(β-D-glucopyranosyl)-20(S)-protopanaxadiol), as a metabolite of ginsenoside, has been verified to have antitumor effects in various cancers, including non-small cell lung cancer (NSCLC). However, the detailed mechanisms of C-K in NSCLC remain largely unknown. In this study, we aimed to evaluate the effect of C-K on apoptosis and autophagy in NSCLC cells as well as its related mechanisms. According to the results, C-K suppressed the proliferation, led to G1 phase arrest and apoptosis in A549 and H1975 cells...
November 26, 2018: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/30475643/shikonin-exerts-antitumor-activity-by-causing-mitochondrial-dysfunction-in-hepatocellular-carcinoma-through-pkm2-ampk-pgc1%C3%AE-signaling-pathway
#14
Bing Liu, Jiangbo Jin, Ziyu Zhang, Li Zuo, Meixiu Jiang, Caifeng Xie
Shikonin, a naphthoquinone derivative isolated from the root of Lithospermum erythrorhizon exhibited broad-spectrum antitumor activity via different molecular mechanisms. In the present study, we investigated the effect of shikonin on the mitochondrial dysfunction in hepatocellular carcinoma (HCC). Our results showed that shikonin inhibited the proliferation, migration, and invasion of HCCLM3 cells, and meanwhile, promoted cell apoptosis in a dose-dependent manner. More importantly, shikonin affected mitochondrial function by disrupting mitochondrial membrane potential and oxidative stress (OS) status...
November 26, 2018: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/30468624/corrigendum-ameliorating-effects-of-sporidiobolus-pararoseus-extract-on-dyslipidemia-in-mice-with-high-fat-diet-induced-obesity
#15
Chao Du, Danyu Ying, Yahui Guo, Yuliang Cheng, Mei Han, Weiguo Zhang, He Qian
No abstract text is available yet for this article.
November 23, 2018: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/30462520/role-of-n-glycosylation-in-the-expression-of-human-slc26a2-and-a3-anion-transport-membrane-glycoproteins
#16
Chloe L Rapp, Jing Li, Katherine E Badior, David B Williams, Joseph R Casey, Reinhart A F Reithmeier
The human solute carrier 26 (SLC26) gene family of anion transporters consists of 10 members (SLC26A1-A11, A10 being a pseudogene) that encode membrane glycoproteins with 14 transmembrane (TM) segments and a C-terminal cytoplasmic sulfate transporter anti-sigma antagonist (STAS) domain. Thus far, mutations in eight members of the SLC26 family (A1 - A6, A8 and A9) have been linked to diseases in humans. Our goal is to characterize the role of N-glycosylation and the effect of mutations in SLC26A2 and A3 proteins on their functional expression in transfected HEK-293 cells...
November 21, 2018: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/30444637/quantum-mechanical-tunnelling-through-the-catalytic-effects-of-a2451-ribosomal-residue-during-a-stepwise-peptide-bond-formation
#17
Hadieh Monajemi, Sharifuddin Mohd Zain, Toshimasa Ishida, Wan Ahmad Tajuddin Wan Abdullah
The search for the mechanism of ribosomal peptide bond formation is still ongoing. Even though the actual mechanism of peptide bod formation is still a dilemma, the dominance of proton transfer in this reaction is known for certain. Therefore, it is vital to take the quantum mechanical effects on proton transfer reaction into consideration, the effects of which were neglected in all previous studies. In this study, we have taken such effects into consideration using a semi-classical approach to the overall reaction mechanism...
November 16, 2018: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/30427707/glutathione-subcellular-distribution-and-membrane-transport
#18
Julian Oestreicher, Bruce Morgan
Glutathione (γ-glutamylcysteinylglycine) is a small tripeptide found at millimolar concentrations in nearly all eukaryotes as well as many prokaryotic cells. Glutathione synthesis is restricted to the cytosol in animals and fungi and to the cytosol and plastids in plants. Nonetheless, glutathione is found in virtually all subcellular compartments. This implies that transporters must exist, which facilitate glutathione transport into and out of the various subcellular compartments. Glutathione may also be exported and imported across the plasma membrane in many cells...
November 14, 2018: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/30427207/lrf-acts-as-an-activator-and-repressor-of-the-human-%C3%AE-like-globin-gene-transcription-in-a-developmental-stage-dependent-manner
#19
Jin Kang, Yujin Kang, Yea Woon Kim, Jaekyeong You, Jihong Kang, Aeri Kim
LRF, a hematopoietic transcription factor, has been suggested to repress fetal γ-globin genes in the human adult stage β-globin locus. Here, to study the role of LRF in the fetal stage β-globin locus we knocked out its expression in erythroid K562 cells, in which the γ-globin genes are mainly transcribed. The γ-globin transcription was reduced in LRF KO cells, and transcription factor binding to the β-globin locus control region hypersensitive sites (LCR HSs) and active histone organization in the LCR HSs were disrupted by the depletion of LRF...
November 14, 2018: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/30412425/how-alcohol-drinking-affects-our-genes-an-epigenetic-point-of-view
#20
Stefania Ciafre', Valentina Carito, Giampiero Ferraguti, Antonio Greco, George N Chaldakov, Marco Fiore, Mauro Ceccanti
This work highlights recent studies in epigenetic mechanisms that play a role in alcoholism, a complex multifactorial disorder. A large body of evidence has shown that alcohol can modify gene expression through epigenetic processes, namely DNA methylation and nucleosomal remodeling via histone modifications. In that vein, chronic ethanol exposure modifies DNA and histone methylation, histone acetylation, and microRNA expression. The alcohol-mediated chromatin remodeling in the brain promotes the transition from use to abuse and addiction...
November 9, 2018: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
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