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Cancer Metastasis Reviews

Rakesh Bhatia, Shailendra K Gautam, Andrew Cannon, Christopher Thompson, Bradley R Hall, Abhijit Aithal, Kasturi Banerjee, Maneesh Jain, Joyce C Solheim, Sushil Kumar, Surinder K Batra
Mucins (MUC) protect epithelial barriers from environmental insult to maintain homeostasis. However, their aberrant overexpression and glycosylation in various malignancies facilitate oncogenic events from inception to metastasis. Mucin-associated sialyl-Tn (sTn) antigens bind to various receptors present on the dendritic cells (DCs), macrophages, and natural killer (NK) cells, resulting in overall immunosuppression by either receptor masking or inhibition of cytolytic activity. MUC1-mediated interaction of tumor cells with innate immune cells hampers cross-presentation of processed antigens on MHC class I molecules...
January 8, 2019: Cancer Metastasis Reviews
Oliver Thews, Anne Riemann
Tumors often show, compared to normal tissues, a markedly decreased extracellular pH resulting from anaerobic or aerobic glycolysis in combination with a reduced removal of acidic metabolites. Several studies indicate that acidosis induces (independently from hypoxia) hematogenous and lymphatic spread of tumor cells worsening the long-term prognosis of tumor patients. This review gives an overview on the impact of low pH on different steps of metastasis including (a) local tumor cell invasion and angiogenesis, (b) intravasation of tumor cells and detachment into the circulation, and (c) adherence of circulating tumor cells, transmigration and invasion in the new host tissue...
January 4, 2019: Cancer Metastasis Reviews
Stephanie Tucker
No abstract text is available yet for this article.
January 4, 2019: Cancer Metastasis Reviews
Harikrishnan Radhakrishnan, Wolfgang Walther, Fabian Zincke, Dennis Kobelt, Francesca Imbastari, Müge Erdem, Benedikt Kortüm, Mathias Dahlmann, Ulrike Stein
Deciphering the paths to metastasis and identifying key molecules driving this process is one important issue for understanding and treatment of cancer. Such a key driver molecule is Metastasis Associated in Colon Cancer 1 (MACC1). A decade long research on this evolutionarily conserved molecule with features of a transcription factor as well as an adapter protein for versatile protein-protein interactions has shown that it has manifold properties driving tumors to their metastatic stage. MACC1 transcriptionally regulates genes involved in epithelial-mesenchymal transition (EMT), including those which are able to directly induce metastasis like c-MET, impacts tumor cell migration and invasion, and induces metastasis in solid cancers...
January 3, 2019: Cancer Metastasis Reviews
Gregory W Auner, S Kiran Koya, Changhe Huang, Brandy Broadbent, Micaela Trexler, Zachary Auner, Angela Elias, Katlyn Curtin Mehne, Michelle A Brusatori
Novel approaches toward understanding the evolution of disease can lead to the discovery of biomarkers that will enable better management of disease progression and improve prognostic evaluation. Raman spectroscopy is a promising investigative and diagnostic tool that can assist in uncovering the molecular basis of disease and provide objective, quantifiable molecular information for diagnosis and treatment evaluation. This technique probes molecular vibrations/rotations associated with chemical bonds in a sample to obtain information on molecular structure, composition, and intermolecular interactions...
December 19, 2018: Cancer Metastasis Reviews
Carolyn J Vivian, Travis M Hagedorn, Roy A Jensen, Amanda E Brinker, Danny R Welch
Many inbred strains of mice develop spontaneous tumors as they age. Recent awareness of the impacts of mitochondrial DNA (mtDNA) on cancer and aging has inspired developing a mitochondrial-nuclear exchange (MNX) mouse model in which nuclear DNA is paired with mitochondrial genomes from other strains of mouse. MNX mice exhibit mtDNA influences on tumorigenicity and metastasis upon mating with transgenic mice. However, we also wanted to investigate spontaneous tumor phenotypes as MNX mice age. Utilizing FVB/NJ, C57BL/6J, C3H/HeN, and BALB/cJ wild-type inbred strains, previously documented phenotypes were observed as expected in MNX mice with the same nuclear background...
December 14, 2018: Cancer Metastasis Reviews
Thomas C Beadnell, Adam D Scheid, Carolyn J Vivian, Danny R Welch
Mitochondrial DNA (mtDNA) encodes for only a fraction of the proteins that are encoded within the nucleus, and therefore has typically been regarded as a lesser player in cancer biology and metastasis. Accumulating evidence, however, supports an increased role for mtDNA impacting tumor progression and metastatic susceptibility. Unfortunately, due to this delay, there is a dearth of data defining the relative contributions of specific mtDNA polymorphisms (SNP), which leads to an inability to effectively use these polymorphisms to guide and enhance therapeutic strategies and diagnosis...
December 12, 2018: Cancer Metastasis Reviews
Shijie Sheng, M Margarida Bernardo, Sijana H Dzinic, Kang Chen, Elisabeth I Heath, Wael A Sakr
The predominant cause of cancer mortality is metastasis. The major impediment to cancer cure is the intrinsic or acquired resistance to currently available therapies. Cancer is heterogeneous at the genetic, epigenetic, and metabolic levels. And, while a molecular-targeted drug may be pathway-precise, it can still fail to achieve wholesome cancer-precise toxicity. In the current review, we discuss the strategic differences between targeting the strengths of cancer cells in phenotypic plasticity and heterogeneity and targeting shared vulnerabilities of cancer cells such as the compromised integrity of membranous organelles...
November 27, 2018: Cancer Metastasis Reviews
J M Houthuijzen, J Jonkers
Tumor cells exist in close proximity with non-malignant cells. Extensive and multilayered crosstalk between tumor cells and stromal cells tailors the tumor microenvironment (TME) to support survival, growth, and metastasis. Fibroblasts are one of the largest populations of non-malignant host cells that can be found within the TME of breast, pancreatic, and prostate tumors. Substantial scientific evidence has shown that these cancer-associated fibroblasts (CAFs) are not only associated with tumors by proximity but are also actively recruited to developing tumors where they can influence other cells of the TME as well as influencing tumor cell survival and metastasis...
November 21, 2018: Cancer Metastasis Reviews
P M Herst, C Grasso, Michael V Berridge
Tumor initiation, progression, and metastasis are tissue context-dependent processes. Cellular and non-cellular factors provide the selective microenvironment that determines the fate of the evolving tumor through mechanisms that include metabolic reprogramming. Genetic and epigenetic changes contribute to this reprogramming process, which is orchestrated through ongoing communication between the mitochondrial and nuclear genomes. Metabolic flexibility, in particular the ability to rapidly adjust the balance between glycolytic and mitochondrial energy production, is a hallmark of aggressive, invasive, and metastatic cancers...
November 17, 2018: Cancer Metastasis Reviews
Masoom Raza, Peeyush Prasad, Pragya Gupta, Naveen Kumar, Taruna Sharma, Mandeep Rana, Aaron Goldman, Seema Sehrawat
Brain metastasis is one of the leading causes of death among cancer patients. Cancer cells migrate to various sites and harbor different niche in the body which help cancer cells in their survival. The brain is one of the safest place where cancer cells are protected from immune cells. Breast, lung, and melanoma cancer cells have high propensity to migrate towards the brain. To enter the brain, cancer cells have to cross the blood brain barrier. Survival and finding new niche in the brain are directed by several mechanisms in which different cellular players take part such as astrocytes, microglia, Schwann cells, satellite cells, oligodendrocytes, and ependymal cells...
October 4, 2018: Cancer Metastasis Reviews
Roberto A Leon-Ferre, Karthik V Giridhar, Tina J Hieken, Robert W Mutter, Fergus J Couch, Rafael E Jimenez, John R Hawse, Judy C Boughey, Kathryn J Ruddy
Male breast cancer is rare, accounting for 1% of all breast cancer diagnoses in the USA. Because of its rarity, most major breast cancer trials have included only female patients. This has resulted in limited prospective data to guide the clinical management of men with breast cancer. As a result, treatment decisions are typically extrapolated from data generated in female patients. This approach may be suboptimal, particularly considering the differing hormonal milieus between men and women with respect to both breast cancer development and treatment...
September 19, 2018: Cancer Metastasis Reviews
Michael A Sirover
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) may represent the quintessential example of a moonlighting protein. The latter are a new, intriguing class of cell proteins which exhibit multiple activities in different subcellular locales apart from their initially, well-characterized function. As such, apart from its classical role in energy production, membrane-bound GAPDH is required for membrane fusion, endocytosis and, intriguingly, for iron transport. Cytoplasmic GAPDH regulates mRNA stability and is required for ER to Golgi trafficking...
September 12, 2018: Cancer Metastasis Reviews
Abhilasha Maheshwari, Paul T Finger
Ocular cancers are unique among the diseases of the eye, threatening both vision and life. In most cases, the diagnosis can be made utilizing a careful clinical history and specialized ocular examination. Eye cancer diagnosis relies heavily on imaging techniques such as high-frequency ultrasound, fluorescein angiography, anterior and posterior segment optical coherence tomography, computed tomography (CT), and magnetic resonance imaging (MRI). Once the diagnosis is established, treatment decisions depend on the tumor's location, size, local extension, patterns of growth, and secondary complications...
September 10, 2018: Cancer Metastasis Reviews
Patrick O Azevedo, Ana E Paiva, Gabryella S P Santos, Luiza Lousado, Julia P Andreotti, Isadora F G Sena, Carlos A Tagliati, Akiva Mintz, Alexander Birbrair
Lung cancer is the leading cause of cancer mortality around the world. The lack of detailed understanding of the cellular and molecular mechanisms participating in the lung tumor progression restrains the development of efficient treatments. Recently, by using state-of-the-art technologies, including in vivo sophisticated Cre/loxP technologies in combination with lung tumor models, it was revealed that osteoblasts activate neutrophils that promote tumor growth in the lung. Strikingly, genetic ablation of osteoblasts abolished lung tumor progression via interruption of SiglecFhigh -expressing neutrophils supply to the tumor microenvironment...
September 10, 2018: Cancer Metastasis Reviews
Zhiyong Wang, Juan Callejas Valera, Xuefeng Zhao, Qianming Chen, J Silvio Gutkind
The author's name was tagged incorrectly in XML. "Silvio Gutkind J" should be tagged as "J. Silvio Gutkind". Given name is "J. Silvio" and the Family name is "Gutkind".
September 5, 2018: Cancer Metastasis Reviews
(no author information available yet)
No abstract text is available yet for this article.
September 2018: Cancer Metastasis Reviews
Megan L Sulciner, Allison Gartung, Molly M Gilligan, Charles N Serhan, Dipak Panigrahy
Bioactive lipids are essential components of human cells and tissues. As discussed in this review, the cancer lipidome is diverse and malleable, with the ability to promote or inhibit cancer pathogenesis. Targeting lipids within the tumor and surrounding microenvironment may be a novel therapeutic approach for treating cancer patients. Additionally, the emergence of a novel super-family of lipid mediators termed specialized pro-resolving mediators (SPMs) has revealed a new role for bioactive lipid mediators in the resolution of inflammation in cancer biology...
September 2018: Cancer Metastasis Reviews
Allison Gartung, Dipak Panigrahy
No abstract text is available yet for this article.
September 2018: Cancer Metastasis Reviews
Preeti Kanikarla-Marie, Scott Kopetz, Ernest T Hawk, Steven W Millward, Anil K Sood, Paolo Gresele, Michael Overman, Kenneth Honn, David G Menter
Platelets can serve as "first responders" in cancer and metastasis. This is partly due to bioactive lipid metabolism that drives both platelet and cancer biology. The two primary eicosanoid metabolites that maintain platelet rapid response homeostasis are prostacyclin made by endothelial cells that inhibits platelet function, which is counterbalanced by thromboxane produced by platelets during activation, aggregation, and platelet recruitment. Both of these arachidonic acid metabolites are inherently unstable due to their chemical structure...
September 2018: Cancer Metastasis Reviews
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