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Animal Genetics

M R S Fortes, L F Zacchi, L T Nguyen, F Raidan, M M D C A Weller, J J Y Choo, A Reverter, J P A Rego, G B Boe-Hansen, L R Porto-Neto, S A Lehnert, A Cánovas, B L Schulz, A Islas-Trejo, J F Medrano, M G Thomas, S S Moore
Progesterone signaling and uterine function are crucial in terms of pregnancy establishment. To investigate how the uterine tissue and its secretion changes in relation to puberty, we sampled tissue and uterine fluid from six pre- and six post-pubertal Brahman heifers. Post-pubertal heifers were sampled in the luteal phase. Gene expression of the uterine tissue was investigated with RNA-sequencing, whereas the uterine fluid was used for protein profiling with mass spectrometry. A total of 4034 genes were differentially expressed (DE) at a nominal P-value of 0...
September 7, 2018: Animal Genetics
Lulan Zeng, Bizhi Huang, Fangyu Li, Ningbo Chen, Zhijie Ma, Kaixing Qu, Hong Chen, Chuzhao Lei
No abstract text is available yet for this article.
September 3, 2018: Animal Genetics
S Mastrangelo, G Sottile, A M Sutera, R Di Gerlando, M Tolone, A Moscarelli, M T Sardina, B Portolano
Microtia is a congenital deformity of the outer ear with phenotypes varying from a small auricle to total absence (anotia). The genetic basis is still poorly understood, and very few studies have been performed in sheep. Valle del Belice sheep is a breed showing microtia. The aim of this study was to identify the potential genomic regions involved in microtia in sheep. A total of 40 individuals, 20 with microtia and 20 normal, were genotyped with the Illumina OvineSNP50 BeadChip. The comparison among the results from a genome-wide association study, Fisher's exact test and FST analysis revealed a single strong association signal: rs419889303 on chromosome 1, located within intron 3 of the CLRN1 gene...
August 30, 2018: Animal Genetics
M Wypchło, A Korwin-Kossakowska, A Bereznowski, M Hecold, D Lewczuk
The aim of this research was to evaluate the polymorphisms of selected genes and to find their potential effect on the occurrence of osteochondrosis in Polish Warmbloods (sport horse breeds). The study was conducted on a group of 198 horses subjected to official performance tests. Investigated joints-fetlock, hock and stifle-were X-rayed twice, once before and again at the end of the tests (first and second examination), and on this basis the degree of disease was evaluated. Based on the results of previous research, 13 candidate genes potentially associated with the occurrence of osteochondrosis were selected and, among them, 32 polymorphisms were tested...
August 28, 2018: Animal Genetics
K E Wurtz, J M Siegford, C W Ernst, N E Raney, R O Bates, J P Steibel
Aggression in group-housed pigs is a welfare concern and can negatively affect production. Skin lesions are reliable indicators of aggression and are moderately heritable, suggesting that selective breeding may reduce aggression. To further understand the genetic control of behavioral traits, such as the aggressive response to regrouping, associated single nucleotide polymorphisms (SNPs) can be identified within the genome, and the region in which these SNPs are located can be related to known genes. To investigate SNPs associated with aggression, 1093 purebred Yorkshire pigs were strategically remixed into new groups of familiar and unfamiliar animals at three life stages and lesion counts were recorded...
August 22, 2018: Animal Genetics
D Aiello, K Patel, E Lasagna
Myostatin, also known as growth differentiation factor 8, a member of the transforming growth factor-beta super-family, is a negative regulator of muscle development. Myostatin acts at key points during pre- and post-natal life of amniotes that ultimately determine the overall muscle mass of an animal. Mutations have already demonstrated the impact of attenuating myostatin activity on muscle development. A number of large animals, including cattle, sheep, dogs and humans, display the 'double muscled' phenotype due to mutations in the myostatin gene...
August 20, 2018: Animal Genetics
T J Kun, E J Wictum, M C T Penedo
Degraded biological samples are a challenge for testing laboratories. Genotyping success can be improved through the use of mini-STRs, by which primers are placed adjacent to the repeat motifs to reduce amplicon size. Here, we present a genetic profiling system comprising 13 autosomal and one X-linked dinucleotide-repeat markers and the SRY gene based on the internationally accepted equine parentage panel. The markers are divided into two panels with all alleles falling at or below 182 bp. The application of this method significantly increases the ability to profile difficult samples and to provide discriminating results to clients...
August 16, 2018: Animal Genetics
F M Rezende, G O Dietsch, F Peñagaricano
The service sire has been recognized as an important factor affecting herd fertility in dairy cattle. Recent studies suggest that genetic factors explain part of the difference in fertility among Holstein sires. The main objective of this study was to dissect the genetic architecture of sire fertility in US Jersey cattle. The dataset included 1.5 K Jersey bulls with sire conception rate (SCR) records and 96 K single nucleotide polymorphism (SNP) markers spanning the whole genome. The analysis included whole-genome scans for both additive and non-additive effects and subsequent functional enrichment analyses using KEGG Pathway, Gene Ontology (GO) and Medical Subject Headings (MeSH) databases...
August 14, 2018: Animal Genetics
T Amano, A Onogi, F Yamada, M Kawai, K Shirai, J Ueda
Previously, a single nucleotide polymorphism (SNP) related to gait type was identified at position 22 999 655 of chromosome 23 in the coding region of DMRT3 (DMRT3:Ser301Ter) by showing that a cytosine (C) to adenine (A) mutation of this SNP induced pace in the Icelandic horse. We investigated the effect of DMRT3:Ser301Ter on the gait of Hokkaido Native Horses, a Japanese native breed, and examined genetic factors other than DMRT3 by exploring genome-wide SNPs related to gait determination. All animals exhibiting pace were AA for DMRT3:Ser301Ter, confirming the association of DMRT3:Ser301Ter with gait determination; however, 14...
August 14, 2018: Animal Genetics
Tereza Jancuskova, Mary Langevin, Sona Pekova
No abstract text is available yet for this article.
August 14, 2018: Animal Genetics
Oriol Vidal
No abstract text is available yet for this article.
August 12, 2018: Animal Genetics
Maura Carrai, Claire M Wade
No abstract text is available yet for this article.
August 5, 2018: Animal Genetics
R Abdoli, S Z Mirhoseini, N Ghavi Hossein-Zadeh, P Zamani, C Gondro
Several causative mutations in candidate genes affecting prolificacy have been detected in various sheep breeds. A genome-wide association study was performed on estimated breeding values for litter size in Lori-Bakhtiari sheep. Prolific ewes with twinning records and others with only singleton records were genotyped using the medium-density Illumina Ovine SNP50 array. Four single nucleotide polymorphisms (SNPs) associated with litter size were identified on chromosomes 3, 6 and 22. The region on sheep chromosome 3 between 75 739 167 and 75 745 152 bp included two significant SNPs (s52383...
August 5, 2018: Animal Genetics
L Zeng, N Chen, Q Ning, Y Yao, H Chen, R Dang, H Zhang, C Lei
With the proposed global climate change, heat tolerance is becoming increasingly important to the sustainability of livestock production systems. Results from previous studies showed that variants in the prolactin releasing hormone (PRLH) (AC_000160.1:g.11764610G>A) and superoxide dismutase 1 (SOD1) (AC_000158.1:g.3116044T>A) genes play an important role in heat tolerance in African indicine cattle. However, it is unknown whether or not the mutations are associated with heat tolerance in Chinese cattle...
August 5, 2018: Animal Genetics
A Cesarani, S Sorbolini, A Criscione, S Bordonaro, G Pulina, G Battacone, D Marletta, G Gaspa, N P P Macciotta
In the present study, a sample of 88 animals belonging to four local (Modicana, Sarda, Sardo-Bruna and Sardo-Modicana) and one cosmopolitan (Italian Brown Swiss) cattle breeds were genotyped with a medium density SNP beadchip and compared to investigate their genetic diversity and the existence of selection signatures. A total of 43 012 SNPs distributed across all 29 autosomal chromosomes were retained after data quality control. Basic population statistics, Wright fixation index and runs of homozygosity (ROH) analyses confirmed that the Italian Brown Swiss genome was shaped mainly by selection, as underlined by the low values of heterozygosity and minor allele frequency...
August 1, 2018: Animal Genetics
L Ma, Z Li, Y Cai, H Xu, R Yang, X Lan
The identification of genetic variations underlying desired phenotypes is one of the main challenges of current livestock genetic research. High-throughput transcriptome sequencing has been recognized as an efficient way to unravel the rich genetic variants across various species. The Lanzhou Fat-Tail sheep is an endangered sheep breed in China with a notable feature of an exaggerated fat tail that also independently occurs in other sheep breeds. However, the genetic mechanism underlying this particular trait has not been fully elucidated yet...
August 1, 2018: Animal Genetics
B Zhao, Y Chen, Y Hao, N Yang, M Wang, M Mei, J Wang, X Qiu, X Wu
Rabbit fur characteristics are primarily genetically determined traits. We used Illumina high-throughput sequencing technology to assess gene expression in the skin tissues of rabbits derived from a cross between Wanxi Angora rabbits and Rex rabbits, which exhibit differential characteristics of short and long wool respectively, to investigate molecular mechanisms related to wool length determination. To identify key regulatory genes involved in rabbit wool length, genes that were differentially expressed between the long- and short-wool rabbits based on a P-value < 0...
August 1, 2018: Animal Genetics
C M Nolan, R E Shiel, J G Buchan, F M O'Sullivan, J J Callanan
Imprinted genes are epigenetically modified in a parent-of-origin dependent manner and as a consequence are differentially expressed, with one allele typically expressed while the other is repressed. In canine, the insulin like growth factor 2 receptor gene (IGF2R) is imprinted with predominant expression of the maternally inherited allele. Because imprinted genes usually occur in clusters, we examined the allelic expression pattern of the gene encoding the canine Mas receptor (MAS1), which is located upstream of IGF2R on canine chromosome 1 and is highly conserved in mammals...
July 30, 2018: Animal Genetics
Shailendra K Mishra, Saket K Niranjan, Bhaswati Banerjee, Ravinder Singh, Prem Kumar, Ranjit S Kataria
No abstract text is available yet for this article.
July 30, 2018: Animal Genetics
S A Rahmatalla, D Arends, M Reissmann, K Wimmers, H Reyer, G A Brockmann
Long-term selection of goats for a certain production system and/or different environmental conditions will be reflected in the body morphology of the animals under selection. To investigate the variation contributing to different morphological traits and to identify genomic regions that are associated with body morphological traits in Sudanese goats, we genotyped 96 females belonging to four Sudanese goat breeds with the SNP52 BeadChip. After quality control of the data, the genome-wide association study was performed using 95 goats and 24 027 informative single nucleotide polymorphisms (SNPs)...
July 30, 2018: Animal Genetics
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