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Animal Genetics

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https://www.readbyqxmd.com/read/28444912/whole-genome-sequencing-reveals-a-novel-deletion-variant-in-the-kit-gene-in-horses-with-white-spotted-coat-colour-phenotypes
#1
N Dürig, R Jude, H Holl, S A Brooks, C Lafayette, V Jagannathan, T Leeb
White spotting phenotypes in horses can range in severity from the common white markings up to completely white horses. EDNRB, KIT, MITF, PAX3 and TRPM1 represent known candidate genes for such phenotypes in horses. For the present study, we re-investigated a large horse family segregating a variable white spotting phenotype, for which conventional Sanger sequencing of the candidate genes' individual exons had failed to reveal the causative variant. We obtained whole genome sequence data from an affected horse and specifically searched for structural variants in the known candidate genes...
April 26, 2017: Animal Genetics
https://www.readbyqxmd.com/read/28378952/haplotype-structure-and-copy-number-polymorphism-of-the-beta-defensin-7-genes-in-diverse-chicken-breeds
#2
M O Lee, M N Romanov, K V Plemyashov, N V Dementieva, O V Mitrofanova, O Y Barkova, J E Womack
Beta-defensins is a family of avian peptides related to the innate immune system. Copy number variation was recently reported for the avian beta-defensin 7 gene (AvBD7) between the highly inbred Leghorn and Fayoumi lines. Here, we examined copy number variants in 35 different chicken breeds and found that 31 of them have at least the same representation of the duplicated AvBD7 allele. We also found haplotypes upstream of the AvBD6 regions that are strongly linked to the AvBD7 duplication. We observed a strong linkage disequilibrium spanning of the upstream region of the AvBD6 gene, with two SNPs being flanking markers to detect duplication of the AvBD7...
April 5, 2017: Animal Genetics
https://www.readbyqxmd.com/read/28378943/exclusion-of-known-progressive-retinal-atrophy-genes-for-blindness-in-the-hungarian-puli
#3
Tracy Chew, Bianca Haase, Cali E Willet, Claire M Wade
No abstract text is available yet for this article.
April 5, 2017: Animal Genetics
https://www.readbyqxmd.com/read/28378922/a-novel-splice-mutation-within-equine-kit-and-the-w15-allele-in-the-homozygous-state-lead-to-all-white-coat-color-phenotypes
#4
Heather M Holl, Samantha A Brooks, Meredith L Carpenter, Carlos D Bustamante, Christa Lafayette
No abstract text is available yet for this article.
April 5, 2017: Animal Genetics
https://www.readbyqxmd.com/read/28370091/genotyping-by-sequencing-reveals-a-new-locus-for-pig-teat-number
#5
L Wang, Y Zhang, T Zhang, L Zhang, H Yan, X Liu, L Wang
Teat number is an extremely valuable trait for sow reproduction performance and piglet survival. Here, we used genotyping-by-sequencing and a general liner model to carry out genome-wide analysis of sow total teat number in an Erhualian population. The results indicated that eight SNPs on chromosomes 4, 5, 9 and 10 were significant genome wide (Bonferroni method, P < 2.85E-7) for sow total teat number. Validation analyses were performed in 298 Erhualian and 904 Large White sows using these significant SNPs and the general liner model procedure in sas...
April 3, 2017: Animal Genetics
https://www.readbyqxmd.com/read/28295460/a-novel-14-bp-duplicated-deletion-within-goat-ghr-gene-is-significantly-associated-with-growth-traits-and-litter-size
#6
Qing Yang, Hailong Yan, Jie Li, Han Xu, Ke Wang, Haijing Zhu, Hong Chen, Lei Qu, Xianyong Lan
No abstract text is available yet for this article.
March 10, 2017: Animal Genetics
https://www.readbyqxmd.com/read/28294375/identification-of-the-interaction-between-bta-mir-370-and-olr1-gene-in-bovine-adipocyte
#7
H F Li, S H Wang, Y Guo, H B Zhao, X Y Li, X Wang
It has been shown that the oxidized low density lipoprotein receptor 1 (OLR1) gene plays an important role in the degradation of oxidized low density lipoprotein. Previous studies found a SNP in the 3'-untranslated region (3'-UTR) of the OLR1 gene associated with milk production traits in different dairy cattle populations and with loin eye area and marbling depth in beef cattle. MicroRNAs can regulate gene expression by binding the 3'-UTR of target genes to degrade or to repress the translation of target genes...
March 10, 2017: Animal Genetics
https://www.readbyqxmd.com/read/28244125/identification-of-a-new-y-chromosome-haplogroup-in-spanish-native-cattle
#8
R Pelayo, M C T Penedo, M Valera, A Molina, L Millon, C Ginja, L J Royo
The aim of this work was to perform a thorough analysis of the diversity of Y-haplotypes in Spanish cattle. A total of 207 Bos taurus males were sampled across 25 European breeds, with a special focus on rare, local Spanish populations. Animals were genotyped with five Y-specific microsatellites (INRA189, UMN0103, UMN0307, BM861 and BYM1), two indels (ZFY10 and USP9Y) and one SNP (UTY19). A new haplogroup, distinct from those described by Götherström et al. (2005), was identified and named Y1.2. Samples representing the three B...
February 27, 2017: Animal Genetics
https://www.readbyqxmd.com/read/28224649/sex-chromosomal-abnormalities-associated-with-equine-infertility-validation-of-a-simple-molecular-screening-tool-in-the-purebred-spanish-horse
#9
G Anaya, A Molina, M Valera, M Moreno-Millán, P Azor, P Peral-García, S Demyda-Peyrás
Chromosomal abnormalities in the sex chromosome pair (ECAX and ECAY) are widely associated with reproductive problems in horses. However, a large proportion of these abnormalities remains undiagnosed due to the lack of an affordable diagnostic tool that allows for avoiding karyotyping tests. Hereby, we developed an STR (single-tandem-repeat)-based molecular method to determine the presence of the main sex chromosomal abnormalities in horses in a fast, cheap and reliable way. The frequency of five ECAX-linked (LEX026, LEX003, TKY38, TKY270 and UCDEQ502) and two ECAY-linked (EcaYH12 and SRY) markers was characterized in 261 Purebred Spanish Horses to determine the efficiency of the methodology developed to be used as a chromosomal diagnostic tool...
February 22, 2017: Animal Genetics
https://www.readbyqxmd.com/read/28220507/relationships-between-inflammation-and-immunity-related-transcript-abundance-in-the-rumen-and-jejunum-of-beef-steers-with-divergent-average-daily-gain
#10
J G Reynolds, A P Foote, H C Freetly, W T Oliver, A K Lindholm-Perry
The bovine rumen papillae are in contact with a wide array of microorganisms and the metabolites they produce, which may activate an inflammatory and/or immune response. Cytokines, chemokines and their receptor genes were tested for differential expression in the rumen and jejunum of beef steers with greater and lesser average daily body weight gain (ADG) near the average daily dry matter intake (DMI) for the population. Angus-sired steers (n = 16) were used to represent the greater (ADG = 2.2 ± 0.07 kg/day; DMI = 10...
February 21, 2017: Animal Genetics
https://www.readbyqxmd.com/read/28262958/an-atlas-and-analysis-of-bovine-skeletal-muscle-long-noncoding-rnas
#11
X F Liu, X B Ding, X Li, C F Jin, Y W Yue, G P Li, H Guo
Long noncoding RNAs (lncRNAs) have various biological functions and have been extensively studied in recent years. However, the identification and characterization of bovine lncRNAs in skeletal muscle has been very limited compared with that of lncRNAs in other model organisms. In this study, 7188 bovine skeletal muscle lncRNAs were identified by RNA-Seq and a stringent screening procedure in four different muscle tissues. These lncRNAs shared many characteristics with other mammalian lncRNAs, such as a shorter open reading frame and lower expression level than for mRNAs...
June 2017: Animal Genetics
https://www.readbyqxmd.com/read/28211150/genomic-prediction-of-reproduction-traits-for-merino-sheep
#12
S Bolormaa, D J Brown, A A Swan, J H J van der Werf, B J Hayes, H D Daetwyler
Economically important reproduction traits in sheep, such as number of lambs weaned and litter size, are expressed only in females and later in life after most selection decisions are made, which makes them ideal candidates for genomic selection. Accurate genomic predictions would lead to greater genetic gain for these traits by enabling accurate selection of young rams with high genetic merit. The aim of this study was to design and evaluate the accuracy of a genomic prediction method for female reproduction in sheep using daughter trait deviations (DTD) for sires and ewe phenotypes (when individual ewes were genotyped) for three reproduction traits: number of lambs born (NLB), litter size (LSIZE) and number of lambs weaned...
June 2017: Animal Genetics
https://www.readbyqxmd.com/read/28198082/pck1-expression-is-correlated-with-the-plasma-glucose-level-in-the-duck
#13
L Chen, T Zeng, G Q Li, R Liu, Y Tian, Q H Li, L Z Lu
Phosphoenolpyruvate carboxykinase 1 (soluble) (PCK1) is a key gene in gluconeogenesis and glyceroneogenesis. Although its functions have been extensively studied in mice, bats and humans, little is known in ducks. Here, PCK1 functions were studied using a duck domestication model and a 48-h fasting experiment. We found PCK1 expression significantly decreased in two breeds of domestic ducks (Jinyun Pockmark ducks and Cherry Valley ducks) as compared with wild ducks (Anas platyrhynchos). Simultaneously, plasma levels of glucose, triglycerides and free fatty acid in domestic ducks were lower than in wild ducks...
June 2017: Animal Genetics
https://www.readbyqxmd.com/read/28198029/asip-gene-variation-in-chinese-donkeys
#14
Ting Sun, Shiying Li, Xiaoting Xia, Chuanliang Ji, Shanyi Shen, Guoliang Zhang, Jie Yu, Guimiao Jiang, Ruihua Dang, Chuzhao Lei
No abstract text is available yet for this article.
June 2017: Animal Genetics
https://www.readbyqxmd.com/read/28176342/identification-of-the-crucial-genes-in-the-elimination-and-survival-process-of-salmonella-enterica-ser-pullorum-in-the-chicken-spleen
#15
T Ma, L Xu, H Wang, X Guo, Z Li, F Wan, J Chen, L Liu, X Liu, G Chang, G Chen
Salmonella enterica ser. Pullorum is one of the most easily re-infecting pathogens in poultry production because of its mechanism of escaping from immune elimination. We used the transcriptome method to investigate the variation in gene expression in chicken spleen resulting from the interaction between hosts and S. Pullorum in the survival process. The expression of various genes related to the maturation and activation of B cells was activated before S. Pullorum was eliminated, which might help S. Pullorum escape from the elimination process...
June 2017: Animal Genetics
https://www.readbyqxmd.com/read/28124378/fine-mapping-of-a-distal-chromosome-4-qtl-affecting-growth-and-muscle-mass-in-a-chicken-advanced-intercross-line
#16
S Lyu, D Arends, M K Nassar, G A Brockmann
In our previous research, QTL analysis in an F2 cross between the inbred New Hampshire (NHI) and White Leghorn (WL77) lines revealed a growth QTL in the distal part of chromosome 4. To physically reduce the chromosomal interval and the number of potential candidate genes, we performed fine mapping using individuals of generations F10 , F11 and F12 in an advanced intercross line that had been established from the initial F2 mapping population. Using nine single nucleotide polymorphism (SNP) markers within the QTL region for an association analysis with several growth traits from hatch to 20 weeks and body composition traits at 20 weeks, we could reduce the confidence interval from 26...
June 2017: Animal Genetics
https://www.readbyqxmd.com/read/28116806/novel-class-ii-alpha-mhc-variability-in-a-small-peripheral-atlantic-salmon-population
#17
Kate L Ciborowski, William C Jordan, Carlos García de Leániz, Sofia Consuegra
No abstract text is available yet for this article.
June 2017: Animal Genetics
https://www.readbyqxmd.com/read/28116762/limited-representation-of-omia-causative-mutations-for-cattle-in-snp-databases
#18
Aditi Sharma, Yongmin Cho, Bong-Hwan Choi, Han-Ha Chai, Jong-Eun Park, Dajeong Lim
No abstract text is available yet for this article.
June 2017: Animal Genetics
https://www.readbyqxmd.com/read/28111759/deletion-of-2-7%C3%A2-kb-near-hoxd3-in-an-arabian-horse-with-occipitoatlantoaxial-malformation
#19
M H Bordbari, M C T Penedo, M Aleman, S J Valberg, J Mickelson, C J Finno
In the horse, the term occipitoatlantoaxial malformation (OAAM) is used to describe a developmental defect in which the first cervical vertebra (atlas) resembles the base of the skull (occiput) and the second cervical vertebra (axis) resembles the atlas. Affected individuals demonstrate an abnormal posture and varying degrees of ataxia. The homeobox (HOX) gene cluster is involved in the development of both the axial and appendicular skeleton. Hoxd3-null mice demonstrate a strikingly similar phenotype to Arabian foals with OAAM...
June 2017: Animal Genetics
https://www.readbyqxmd.com/read/28094451/development-of-diversity-arrays-technology-markers-as-a-tool-for-rapid-genomic-assessment-in-nile-tilapia-oreochromis-niloticus
#20
C E Lind, A Kilian, J A H Benzie
The development of genomic markers is described for Nile tilapia, Oreochromis niloticus, using the Diversity Arrays Technology (DArT) genotype-by-sequencing platform. A total of 13 215 single nucleotide polymorphism (SNP) markers and 12 490 silicoDArT (dominant) markers were identified from broodstock of two selective breeding programs [Genetically Improved Farmed Tilapia (GIFT) strain from Malaysia and the Abbassa strain from Egypt]. Over 10 000 SNPs were polymorphic in either strain, and 2985 and 3087 showed strain-specific polymorphisms for the GIFT and Abbassa strains respectively...
June 2017: Animal Genetics
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