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Animal Genetics

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https://www.readbyqxmd.com/read/27917507/evidence-of-a-genomic-insertion-in-intron-2-of-sod1-causing-allelic-drop-out-during-routine-diagnostic-testing-for-canine-degenerative-myelopathy
#1
M E Turba, R Loechel, E Rombolà, G Gandini, F Gentilini
Degenerative myelopathy is a severe and progressive neurodegenerative disease and, in the majority of breeds, is associated with the c.118G>A substitution in exon 2 of the canine superoxide dismutase 1 (SOD1) gene. Our laboratories have been engaged in determining the cause of many discordant findings between the parental and the offspring genotypes found by different laboratories. In both cases, the discordant findings refer to actual heterozygous dogs that had been typed as homozygous for the variant allele...
December 4, 2016: Animal Genetics
https://www.readbyqxmd.com/read/27910110/runs-of-homozygosity-current-knowledge-and-applications-in-livestock
#2
REVIEW
E Peripolli, D P Munari, M V G B Silva, A L F Lima, R Irgang, F Baldi
This review presents a broader approach to the implementation and study of runs of homozygosity (ROH) in animal populations, focusing on identifying and characterizing ROH and their practical implications. ROH are continuous homozygous segments that are common in individuals and populations. The ability of these homozygous segments to give insight into a population's genetic events makes them a useful tool that can provide information about the demographic evolution of a population over time. Furthermore, ROH provide useful information about the genetic relatedness among individuals, helping to minimize the inbreeding rate and also helping to expose deleterious variants in the genome...
December 1, 2016: Animal Genetics
https://www.readbyqxmd.com/read/27885693/association-of-single-nucleotide-polymorphism-in-melatonin-receptor-1a-gene-with-egg-production-traits-in-yangzhou-geese
#3
M A Alsiddig, S G Yu, Z X Pan, H Widaa, T M Badri, J Chen, H L Liu
In the present study the melatonin receptor 1A gene (MTNR1A) was proposed to be a candidate gene for egg production in Yangzhou geese. A total of 210 goose blood samples were collected to investigate the association of the MTNR1A gene with the number of eggs produced. Using a direct sequencing method, a single nucleotide polymorphism (SNP; g.177G>C) was detected in the 5' regulatory region of the MTNR1A gene (Genbank ss1985399687). Two alleles (G and C) and three genotypes were identified. Association analysis results showed that the g...
November 24, 2016: Animal Genetics
https://www.readbyqxmd.com/read/27878834/characterization-of-mirnas-involved-in-response-to-poly-i-c-in-porcine-airway-epithelial-cells
#4
L Wang, J K Wang, L X Han, J S Zhuo, X Du, D Liu, X Q Yang
MicroRNAs (miRNA) have been implicated in a variety of pathological conditions including infectious diseases. Knowledge of the miRNAs affected by poly(I:C), a synthetic analog of viral double-stranded RNA, in porcine airway epithelial cells (PAECs) contributes to understanding the mechanisms of swine viral respiratory diseases, which bring enormous economic loss worldwide every year. In this study, we used high throughput sequencing to profile miRNA expression in PAECs treated with poly(I:C) as compared to the untreated control...
November 22, 2016: Animal Genetics
https://www.readbyqxmd.com/read/27878829/genetic-association-of-plag1-scd-cyp7b1-and-fasn-snps-and-their-effects-on-carcass-weight-intramuscular-fat-and-fatty-acid-composition-in-hanwoo-steers-korean-cattle
#5
Hyun Joo Kim, Aditi Sharma, Soo Hyun Lee, Doo Ho Lee, Da Jeong Lim, Yong Min Cho, Boh Suk Yang, Seung Hwan Lee
No abstract text is available yet for this article.
November 22, 2016: Animal Genetics
https://www.readbyqxmd.com/read/27862083/biallelic-%C3%AE-carotene-oxygenase-2-knockout-results-in-yellow-fat-in-sheep-via-crispr-cas9
#6
Y Niu, M Jin, Y Li, P Li, J Zhou, X Wang, B Petersen, X Huang, Q Kou, Y Chen
The recently emerged CRISPR/Cas9 approach represents an efficient and versatile genome editing tool for producing genetically modified animals. Β-carotene oxygenase 2 (BCO2) is a key enzyme in the progress of β-carotene metabolism and is associated with yellow adipose tissue color in sheep. We have recently demonstrated targeted multiplex mutagenesis in sheep and have generated a group of BCO2-disrupted sheep by zygote injection of the CRISPR/Cas9 components. Here, we show that biallelic modification of BCO2 resulted in yellow fat, compared with the fat color in monoallelic individuals and wild types (snow-flower white)...
November 16, 2016: Animal Genetics
https://www.readbyqxmd.com/read/27862128/regulation-of-crucial-lncrnas-in-differentiation-of-chicken-embryonic-stem-cells-to-spermatogonia-stem-cells
#7
D Li, Y Ji, F Wang, Y Wang, M Wang, C Zhang, W Zhang, Z Lu, C Sun, M F Ahmed, N He, K Jin, S Cheng, Y Wang, Y He, J Song, Y Zhang, B Li
Regulation of crucial lncRNAs involved in differentiation of chicken embryonic stem cells (ESCs) to spermatogonia stem cells (SSCs) was explored by sequencing the transcriptome of ESCs, primordial germ cells (PGCs) and SSCs with RNA-Seq; analytical bioinformatic methods were used to excavate candidate lncRNAs. We detected expression of candidate lncRNAs in ESCs, PGCs and SSCs and forecasted related target genes. Utilizing wego, david and string, function and protein-protein interactions of target genes were analyzed...
November 14, 2016: Animal Genetics
https://www.readbyqxmd.com/read/27807880/selection-signature-analysis-reveals-genes-associated-with-tail-type-in-chinese-indigenous-sheep
#8
Z Yuan, E Liu, Z Liu, J W Kijas, C Zhu, S Hu, X Ma, L Zhang, L Du, H Wang, C Wei
Fat-tailed sheep have commercial value because consumers prefer high-protein and low-fat food and producers care about feed conversion rate. However, fat-tailed sheep still have some scientific significance, as the fat tail is commonly regarded as a characteristic of environmental adaptability. Finding the candidate genes associated with fat tail formation is essential for breeding and conservation. To identify these candidate genes, we applied FST and hapFLK approaches in fat- and thin-tailed sheep with available 50K SNP genotype data...
November 3, 2016: Animal Genetics
https://www.readbyqxmd.com/read/27781291/expressed-microrna-associated-with-high-rate-of-egg-production-in-chicken-ovarian-follicles
#9
N Wu, U Gaur, Q Zhu, B Chen, Z Xu, X Zhao, M Yang, D Li
MicroRNA (miRNA) is a highly conserved class of small noncoding RNA about 19-24 nucleotides in length that function in a specific manner to post-transcriptionally regulate gene expression in organisms. Tissue miRNA expression studies have discovered a myriad of functions for miRNAs in various aspects, but a role for miRNAs in chicken ovarian tissue at 300 days of age has not hitherto been reported. In this study, we performed the first miRNA analysis of ovarian tissues in chickens with low and high rates of egg production using high-throughput sequencing...
October 26, 2016: Animal Genetics
https://www.readbyqxmd.com/read/27775171/discovery-of-porcine-mirna-196a-b-may-influence-porcine-adipogenesis-in-longissimus-dorsi-muscle-by-mirna-sequencing
#10
Linqing Liu, Kun Qian, Chonglong Wang
Intramuscular fat (IMF) is one of the fat traits that has economic importance in the pork industry. Longissimus dorsi muscle contains IMF and is suitable for studying adipogenesis. To discover further potential regulatory miRNAs that may influence adipogenesis, we analyzed miRNA in the longissimus dorsi muscle of Yorkshire (YY, lean-type) and Chinese Wannanhua (WH, fatty) pigs using miRNA sequencing (miRNA-seq). From this dataset, we identified 598 unique miRNAs comprising 325 pre-miRNAs and 273 novel pre-miRNAs through comparison with known miRNAs in miRBase version 21...
October 24, 2016: Animal Genetics
https://www.readbyqxmd.com/read/27775167/genetic-diversity-and-phylogeographic-structure-of-bactrian-camels-shown-by-mitochondrial-sequence-variations
#11
L Ming, L Yi, R Sa, Z X Wang, Z Wang, R Ji
The Bactrian camel includes various domestic (Camelus bactrianus) and wild (Camelus ferus) breeds that are important for transportation and for their nutritional value. However, there is a lack of extensive information on their genetic diversity and phylogeographic structure. Here, we studied these parameters by examining an 809-bp mtDNA fragment from 113 individuals, representing 11 domestic breeds, one wild breed and two hybrid individuals. We found 15 different haplotypes, and the phylogenetic analysis suggests that domestic and wild Bactrian camels have two distinct lineages...
October 24, 2016: Animal Genetics
https://www.readbyqxmd.com/read/27775157/genome-wide-copy-number-variation-in-the-bovine-genome-detected-using-low-coverage-sequence-of-popular-beef-breeds
#12
B N Keel, J W Keele, W M Snelling
Copy number variations (CNVs) are large insertions, deletions or duplications in the genome that vary between members of a species and are known to affect a wide variety of phenotypic traits. In this study, we identified CNVs in a population of bulls using low coverage next-generation sequence data. First, in order to determine a suitable strategy for CNV detection in our data, we compared the performance of three distinct CNV detection algorithms on benchmark CNV datasets and concluded that using the multiple sample read depth approach was the best method for identifying CNVs in our sequences...
October 24, 2016: Animal Genetics
https://www.readbyqxmd.com/read/27739092/the-tumor-necrosis-factor-g1022g-a-polymorphism-is-associated-with-resistance-to-tuberculosis-in-water-buffalo-bubalus-bubalis
#13
Marina Papaianni, Gianfranco Cosenza, Giorgia Borriello, Giorgio Galiero, Fernando Grasso, Bartolomeo Della Ventura, Marco Iannaccone, Rosanna Capparelli
No abstract text is available yet for this article.
October 14, 2016: Animal Genetics
https://www.readbyqxmd.com/read/27739082/hsfy-and-znf280by-show-copy-number-variations-within-17-water-buffalo-populations
#14
X Zhang, H Han, T Zhang, T Sun, Y Xi, N Chen, Y Huang, R Dang, X Lan, H Chen, C Lei
Recent transcriptomic analysis of the bovine Y chromosome revealed abundant presence of multi-copy protein coding gene families on the male-specific region of the Y chromosome (MSY). Copy number variations (CNVs) of several MSY genes are closely related to semen quality and male reproduction in cattle. However, the CNVs of MSY genes in water buffalo are largely unknown. Therefore, this study aimed to investigate the CNVs of HSFY and ZNF280BY of 298 buffaloes from 17 populations distributed in China, Vietnam and Laos using quantitative PCR...
October 14, 2016: Animal Genetics
https://www.readbyqxmd.com/read/27699807/diversity-and-linkage-disequilibrium-in-farmed-tasmanian-atlantic-salmon
#15
J Kijas, N Elliot, P Kube, B Evans, N Botwright, H King, C R Primmer, K Verbyla
Farmed Atlantic salmon (Salmo salar) is a globally important production species, including in Australia where breeding and selection has been in progress since the 1960s. The recent development of SNP genotyping platforms means genome-wide association and genomic prediction can now be implemented to speed genetic gain. As a precursor, this study collected genotypes at 218 132 SNPs in 777 fish from a Tasmanian breeding population to assess levels of genetic diversity, the strength of linkage disequilibrium (LD) and imputation accuracy...
October 4, 2016: Animal Genetics
https://www.readbyqxmd.com/read/27671997/not-another-type-of-potato-mc1r-and-the-russet-coloration-of-burmese-cats
#16
N A Gustafson, B Gandolfi, L A Lyons
The Burmese is a breed of domestic cat that originated in Southeast Asia and was further developed in the United States. Variants in melanocortin 1 receptor (MC1R) causes common coat colour phenotypes in a variety of mammalian species but only limited colour variation in the domestic cat. Known as the extension (E) locus, melanocortin 1 receptor (MC1R) interacts with the agouti locus to produce the eumelanin and pheomelanin pigments. Recently, a novel reddish coloration, which is termed russet, was identified in the Burmese cat breed...
September 27, 2016: Animal Genetics
https://www.readbyqxmd.com/read/27650416/bayesian-analysis-of-parent-specific-transmission-ratio-distortion-in-seven-spanish-beef-cattle-breeds
#17
J Casellas, J J Cañas-Álvarez, A González-Rodríguez, A Puig-Oliveras, M Fina, J Piedrafita, A Molina, C Díaz, J A Baró, L Varona
Transmission ratio distortion (TRD) is the departure from the expected Mendelian ratio in offspring, a poorly investigated biological phenomenon in livestock species. Given the current availability of specific parametric methods for the analysis of segregation data, this study focused on the screening of TRD in 602 402 single nucleotide polymorphisms covering all autosomal chromosomes in seven Spanish beef cattle breeds. On average, 0.13% (n = 786) and 0.01% (n = 29) of genetic markers evidenced sire- or dam-specific TRD respectively...
September 21, 2016: Animal Genetics
https://www.readbyqxmd.com/read/27650317/identification-of-molecular-markers-for-oocyte-competence-in-bovine-cumulus-cells
#18
E O Melo, D M Cordeiro, R Pellegrino, Z Wei, Z J Daye, R C Nishimura, M A N Dode
Cumulus cells (CCs) have an important role during oocyte growth, competence acquisition, maturation, ovulation and fertilization. In an attempt to isolate potential biomarkers for bovine in vitro fertilization, we identified genes differentially expressed in bovine CCs from oocytes with different competence statuses, through microarray analysis. The model of follicle size, in which competent cumulus-oocyte complexes (COCs) were recovered from bigger follicles (≥8.0 mm in diameter) and less competent ones from smaller follicles (1-3 mm), was used...
September 21, 2016: Animal Genetics
https://www.readbyqxmd.com/read/27646648/genome-wide-proteomics-analysis-on-longissimus-muscles-in-qinchuan-beef-cattle
#19
Hua He, Si Chen, Wei Liang, Xiaolin Liu
To gain further insight into the molecular mechanism of bovine muscle development, we combined mass spectrometry characterization of proteins with Illumina deep sequencing of RNAs obtained from bovine longissimus muscle (LD) at prenatal and postnatal stages. For the proteomic study, each group of LD proteins was extracted and labeled using isobaric tags for relative and absolute quantitation (iTRAQ) method. Among the 1321 proteins identified from six samples, 390 proteins were differentially expressed in embryos at day 135 post-fertilization (Emb135d) vs...
September 19, 2016: Animal Genetics
https://www.readbyqxmd.com/read/27646552/single-nucleotide-polymorphisms-in-exomes-of-high-and-low-marbled-meats-in-korean-cattle
#20
Sungchul Shin, Changpyo Hong, Sanghoon Song, Kung Ahn, Euiryong Chung
No abstract text is available yet for this article.
September 19, 2016: Animal Genetics
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