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Animal Genetics

M Singer-Berk, K E Knickelbein, S Vig, J Liu, E Bentley, C Nunnery, C Reilly, A Dwyer, C Drögemüller, L Unger, V Gerber, M Lassaline, R R Bellone
Squamous cell carcinoma (SCC) is the most common cancer affecting the equine eye, with a higher incidence documented in Haflinger horses. Recently, a missense variant in the gene damage specific DNA binding protein 2 (DDB2, p.Thr338Met) on ECA12 was identified as a risk factor for the development of limbal SCC in Haflinger horses. SCC also occurs on the nictitating membrane; therefore, investigating the role of this missense variant in nictitating membrane SCC is warranted. In this study, a common ancestor was identified among Haflinger horses affected with limbal SCC or with nictitating membrane SCC, thus supporting a recessive risk factor for the development of cancer at both ocular locations...
July 12, 2018: Animal Genetics
Marco Iannaccone, Gianfranco Cosenza, Alfredo Pauciullo, Giuseppe Martino, Rosanna Capparelli
No abstract text is available yet for this article.
July 12, 2018: Animal Genetics
P Stratz, M Schmid, R Wellmann, S Preuß, I Blaj, J Tetens, G Thaller, J Bennewitz
In the present study, data from four F2 crosses were analysed and used to study the linkage disequilibrium (LD) structure within and across the crosses. Genome-wide association analyses (GWASes) for conductivity and dressing out meat traits were conducted using single-marker and Bayesian multi-marker models using the pooled data from all F2 crosses. Porcine F2 crosses generated from the distantly related founder breeds Wild Boar, Piétrain and Meishan, as well as from a porcine F2 cross from the closely related founder breed Piétrain and an F1 Large White × Landrace cross were pooled...
July 6, 2018: Animal Genetics
Y Chen, Y Wang, S Jiang, J Zhang, Z Lü, S Deng
The large yellow croaker, Larimichthys crocea, is a commercially important drum fish (Family: Sciaenidae) native to the East and South China Sea. Habitat deterioration and overfishing have led to significant population decline and the collapse of its fishery over the past decades. Today, the market supply of L. crocea depends solely on stocks produced in hatcheries and farms. Common issues that occur in the culture of L. crocea include germplasm degradation, precocious puberty, elevated disease susceptibility and growth retardation...
July 5, 2018: Animal Genetics
R M Araguas, N Sanz, J Viñas, O Vidal
The melanocortin 1 receptor (MC1R) gene was investigated as a candidate for plumage variations in Chinese painted quail, Coturnix chinensis. Four silent and two missense nucleotide polymorphisms were identified. The correspondent amino acid changes, p.Glu92Lys and p.Pro292Leu, were found in Blue Face and Red Breasted animals respectively. Blue Face is a melanic phenotype similar to the co-dominant Extended Brown of Japanese quail, and both share the p.Glu92Lys mutation. The association of p.Pro292Leu with the recessive Red Breasted was confirmed in 23 animals from an experimental F2 cross...
July 5, 2018: Animal Genetics
J Friedrich, R Antolín, S M Edwards, E Sánchez-Molano, M J Haskell, J M Hickey, P Wiener
The dog is a valuable model species for the genetic analysis of complex traits, and the use of genotype imputation in dogs will be an important tool for future studies. It is of particular interest to analyse the effect of factors like single nucleotide polymorphism (SNP) density of genotyping arrays and relatedness between dogs on imputation accuracy due to the acknowledged genetic and pedigree structure of dog breeds. In this study, we simulated different genotyping strategies based on data from 1179 Labrador Retriever dogs...
July 5, 2018: Animal Genetics
X Yang, H Zhang, J Shang, G Liu, T Xia, C Zhao, G Sun, H Dou
Dogs were domesticated by human and originated from wolves. Their evolutionary relationships have attracted much scientific interest due to their genetic affinity but different habitats. To identify the differences between dogs and wolves associated with domestication, we analysed the blood transcriptomes of wolves and dogs by RNA-Seq. We obtained a total of 30.87 Gb of raw reads from two dogs and three wolves using RNA-Seq technology. Comparisons of the wolf and dog transcriptomes revealed 524 genes differentially expressed genes between them...
June 28, 2018: Animal Genetics
Feng Yu, Shuyu Jiao, Weining Lai, Zhengxi Liu, Mingyuan Zhu, Wanju Zhu, Chunyan Bai, Yonghong Zhang, Jiabao Zhang, Shouqing Yan
No abstract text is available yet for this article.
June 27, 2018: Animal Genetics
N Dürig, A Letko, V Lepori, S Hadji Rasouliha, R Loechel, A Kehl, M K Hytönen, H Lohi, N Mauri, J Dietrich, M Wiedmer, M Drögemüller, V Jagannathan, S M Schmutz, T Leeb
Loss-of-function variants in the MC1R gene cause recessive red or yellow coat-colour phenotypes in many species. The canine MC1R:c.916C>T (p.Arg306Ter) variant is widespread and found in a homozygous state in many uniformly yellow- or red-coloured dogs. We investigated cream-coloured Australian Cattle Dogs whose coat colour could not be explained by this variant. A genome-wide association study with 10 cream and 123 red Australian Cattle Dogs confirmed that the cream locus indeed maps to MC1R. Whole-genome sequencing of cream dogs revealed a single nucleotide variant within the MITF binding site of the canine MC1R promoter...
June 22, 2018: Animal Genetics
D Luo, X Ma, J Bai, Z Zhou, F Wang, A Wang, J Wang
Timidity in dogs is a trait with high heritability. However, the relevant genetic factors and markers associated with this condition are largely unknown. The function of the catechol-O-methyl transferase (COMT) gene has been found to be associated with human fearful or anxious emotions, and the COMT:p.Val158Met polymorphism locus is significantly related to anxious behavior. In the present study, the correlation between timidity and four single nucleotide polymorphism (SNP) variations (C.-1666C>G c.39A>G, c...
June 22, 2018: Animal Genetics
T Chang, J Xia, L Xu, X Wang, B Zhu, L Zhang, X Gao, Y Chen, J Li, H Gao
A genome-wide association study (GWAS) was conducted for two carcass traits in Chinese Simmental beef cattle. The experimental population consisted of 1301 individuals genotyped with the Illumina BovineHD SNP BeadChip (770K). After quality control, 671 990 SNPs and 1217 individuals were retained for the GWAS. The phenotypic traits included carcass weight and bone weight, which were measured after the cattle were slaughtered at 16 to 18 months of age. Three statistical models-a fixed polygene model, a random polygene model and a composite interval mapping polygene model-were used for the GWAS...
June 22, 2018: Animal Genetics
Lingrong Bai, Hua Gong, Huitong Zhou, Jingzhong Tao, Jon G H Hickford
No abstract text is available yet for this article.
June 22, 2018: Animal Genetics
Marina Braun, Sina Reinartz, Maike Heppelmann, Jürgen Rehage, Christian Sürie, Ottmar Distl, Julia Metzger
No abstract text is available yet for this article.
June 22, 2018: Animal Genetics
M Tuiskula-Haavisto, M Honkatukia, I C Dunn, M M Bain, D J De Koning, R Preisinger, M Schmutz, J Arango, D Fischer, J Vilkki
Compromised eggshell quality causes considerable economic losses for the egg industry. Breeding for improved eggshell quality has been very challenging. Eggshell quality is a trait that would greatly benefit from marker-assisted selection, which would allow the selection of sires for their direct contribution to the trait and would also allow implementation of measurements integrating a number of shell parameters that are difficult to measure. In this study, we selected the most promising autosomal quantitative trait loci (QTL) affecting eggshell quality on chromosomes 2, 3, 6 and 14 from earlier experiments and we extended the F2 population to include 1599 F2 females...
May 24, 2018: Animal Genetics
L Gao, S-S Xu, J-Q Yang, M Shen, M-H Li
Variations in ear size can be observed in livestock such as sheep; however, the genetic basis of variable ear size in sheep is still poorly understood. To investigate causative genes associated with ear size in sheep, a genome-wide association study was performed in 115 adult Duolang sheep with different-sized floppy ears using the Ovine Infinium HD BeadChip. We found 38 significant SNPs at the genome-wide or chromosome-wise 5% significance level after Bonferroni correction. The most significant association (P = 1...
May 18, 2018: Animal Genetics
Sina Reinartz, Christine Weiß, Reinhard Mischke, Ottmar Distl
No abstract text is available yet for this article.
May 18, 2018: Animal Genetics
Yu Zhang, Meng Wang, Jiao Yuan, Xiang Zhou, Sanping Xu, Bang Liu
No abstract text is available yet for this article.
May 18, 2018: Animal Genetics
S Joller, P Ammann, C Flury, C Drögemüller
The crest in chicken consists of elongated and upraised feathers, as seen in various breeds such as the Silkie chicken. Recently, the still unknown causative mutation for the crest phenotype was assigned to chromosome 33 and an ectopic expression of HOXC8 was shown. The aim this study was to evaluate whether the crest phenotype in a local Swiss chicken breed, the Appenzeller Spitzhaubenhuhn, is associated with HOXC8. Three previously reported crest-associated flanking markers at the HOXC8 locus were genotyped in cohorts of this breed and two other local breeds without the crest phenotype...
May 18, 2018: Animal Genetics
Yu Ueda, Ronald Hak Long Li, Fern Tablin, Eric S Ontiveros, Joshua A Stern
No abstract text is available yet for this article.
May 18, 2018: Animal Genetics
Zonggang Luo, Yuhui Wu, Wen-Xiu Zhang, Ling Wang, Fuyuan Zuo, Gong-Wei Zhang
No abstract text is available yet for this article.
May 18, 2018: Animal Genetics
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