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Animal Genetics

S Cirera, A Clop, M J Jacobsen, M Guerin, P Lesnik, C B Jørgensen, M Fredholm, P Karlskov-Mortensen
Taste receptors (TASRs) and appetite and reward (AR) mechanisms influence eating behaviour, which in turn affects food intake and risk of obesity. In a previous study, we used next generation sequencing to identify potentially functional mutations in TASR and AR genes and found indications for genetic associations between identified variants and growth and fat deposition in a subgroup of animals (n = 38) from the UNIK resource pig population. This population was created for studying obesity and obesity-related diseases...
February 14, 2018: Animal Genetics
Xiaohong He, Shen Song, Xiaofei Chen, Tianzeng Song, Tenzin Lobsang, Weijun Guan, Yabin Pu, Qianjun Zhao, Lin Jiang, Yuehui Ma
No abstract text is available yet for this article.
February 14, 2018: Animal Genetics
A Bauer, J Nimmo, R Newman, M Brunner, M M Welle, V Jagannathan, T Leeb
Hereditary nasal parakeratosis (HNPK), described in the Labrador Retriever breed, is a monogenic autosomal recessive disorder that causes crusts and fissures on the nasal planum of otherwise healthy dogs. Our group previously showed that this genodermatosis may be caused by a missense variant located in the SUV39H2 gene encoding a histone 3 lysine 9 methyltransferase, a chromatin modifying enzyme with a potential role in keratinocyte differentiation. In the present study, we investigated a litter of Greyhounds in which six out of eight puppies were affected with parakeratotic lesions restricted to the nasal planum...
February 9, 2018: Animal Genetics
Y Wang, X Ding, Z Tan, K Xing, T Yang, Y Wang, D Sun, C Wang
Using the PorcineSNP80 BeadChip, we performed a genome-wide association study for seven reproductive traits, including total number born, number born alive, litter birth weight, average birth weight, gestation length, age at first service and age at first farrowing, in a population of 1207 Large White pigs. In total, we detected 12 genome-wide significant and 41 suggestive significant SNPs associated with six reproductive traits. The proportion of phenotypic variance explained by all significant SNPs for each trait ranged from 4...
February 7, 2018: Animal Genetics
Z Zhang, Y Jia, Y Chen, L Wang, X Lv, F Yang, Y He, Z Ning, L Qu
It is well known that both British and American Pekin ducks originated from China. However, the populations differ substantially in production performance, but the genetic changes involved are still poorly understood. Herein, we sequenced 24 individual Pekin ducks (eight from each population) with an average sequencing depth of more than 45× for each population (mean coverage of 6.29 per individual). Among these populations from three different countries, we identified a large number of SNPs and indels as well as many unique population variants, which can be used as population-specific molecular markers...
February 1, 2018: Animal Genetics
S Tsairidou, A R Allen, R Pong-Wong, S H McBride, D M Wright, O Matika, C M Pooley, S W J McDowell, E J Glass, R A Skuce, S C Bishop, J A Woolliams
Genetic selection of cattle more resistant to bovine tuberculosis (bTB) may offer a complementary control strategy. Hypothesising underlying non-additive genetic variation, we present an approach using genome-wide high density markers to identify genomic loci with dominance effects on bTB resistance and to test previously published regions with heterozygote advantage in bTB. Our data comprised 1151 Holstein-Friesian cows from Northern Ireland, confirmed bTB cases and controls, genotyped with the 700K Illumina BeadChip...
January 24, 2018: Animal Genetics
Isabelle Schmutz, Vidhya Jagannathan, Sabina Diez Bernal, Simone Lanz, Ted Kalbfleisch, Tosso Leeb, Claudia Spadavecchia
No abstract text is available yet for this article.
January 23, 2018: Animal Genetics
A Bauer, A Kehl, V Jagannathan, T Leeb
Coat colour dilution may be the result of altered melanosome transport in melanocytes. Loss-of-function variants in the melanophilin gene (MLPH) cause a recessively inherited form of coat colour dilution in many mammalian and avian species including the dog. MLPH corresponds to the D locus in many domestic animals, and recessive alleles at this locus are frequently denoted with d. In this study, we investigated dilute coloured Chow Chows whose coat colour could not be explained by their genotype at the previously known MLPH:c...
January 19, 2018: Animal Genetics
R B Onzima, M R Upadhyay, R Mukiibi, E Kanis, M A M Groenen, R P M A Crooijmans
Uganda has a large population of goats, predominantly from indigenous breeds reared in diverse production systems, whose existence is threatened by crossbreeding with exotic Boer goats. Knowledge about the genetic characteristics and relationships among these Ugandan goat breeds and the potential admixture with Boer goats is still limited. Using a medium-density single nucleotide polymorphism (SNP) panel, we assessed the genetic diversity, population structure and admixture in six goat breeds in Uganda: Boer, Karamojong, Kigezi, Mubende, Small East African and Sebei...
January 17, 2018: Animal Genetics
Rhiarn Hoban, Kao Castle, Natasha Hamilton, Bianca Haase
No abstract text is available yet for this article.
January 15, 2018: Animal Genetics
S Felkel, C Vogl, D Rigler, V Jagannathan, T Leeb, R Fries, M Neuditschko, S Rieder, B Velie, G Lindgren, C-J Rubin, C Schlötterer, T Rattei, G Brem, B Wallner
Humans have shaped the population history of the horse ever since domestication about 5500 years ago. Comparative analyses of the Y chromosome can illuminate the paternal origin of modern horse breeds. This may also reveal different breeding strategies that led to the formation of extant breeds. Recently, a horse Y-chromosomal phylogeny of modern horses based on 1.46 Mb of the male-specific Y (MSY) was generated. We extended this dataset with 52 samples from five European, two American and seven Asian breeds...
January 15, 2018: Animal Genetics
S Mastrangelo, E Ciani, M T Sardina, G Sottile, F Pilla, B Portolano
The availability of dense single nucleotide polymorphism (SNP) assays allows for the determination of autozygous segments based on runs of consecutive homozygous genotypes (ROH). The aim of the present study was to investigate the occurrence and distribution of ROH in 21 Italian sheep breeds using medium-density SNP genotypes in order to characterize autozygosity and identify genomic regions that frequently appeared in ROH within individuals, namely ROH islands. After filtering, the final number of animals and SNPs retained for analyses were 502 and 46 277 respectively...
January 15, 2018: Animal Genetics
S Ishihara, A Arakawa, M Taniguchi, Q M Luu, D L Pham, B V Nguyen, S Mikawa, K Kikuchi
Vietnam is one of the most important countries for pig domestication, and a total of 26 local breeds have been reported. In the present study, genetic relationships among the various pig breeds were investigated using 90 samples collected from local pigs (15 breeds) in 15 distantly separated, distinct areas of the country and six samples from Landrace pigs in Hanoi as an out-group of a common Western breed. All samples were genotyped using the Illumina Porcine SNP60 v2 Genotyping BeadChip. We used 15 160-15 217 SNPs that showed a high degree of polymorphism in the Vietnamese breeds for identifying genetic relationships among the Vietnamese breeds...
January 15, 2018: Animal Genetics
Zhihua Ju, Qiang Jiang, Gang Liu, Xiuge Wang, Guojing Luo, Yan Zhang, Jibin Zhang, Jifeng Zhong, Jinming Huang
Identification of microRNAs (miRNAs), target genes and regulatory networks associated with innate immune and inflammatory responses and tissue damage is essential to elucidate the molecular and genetic mechanisms for resistance to mastitis. In this study, a combination of Solexa sequencing and custom miRNA chip approaches was used to profile the expression of miRNAs in bovine mammary gland at the late stage of natural infection with Staphylococcus aureus, a widespread mastitis pathogen. We found 383 loci corresponding to 277 known and 49 putative novel miRNAs, two potential mitrons and 266 differentially expressed miRNAs in the healthy and mastitic cows' mammary glands...
January 8, 2018: Animal Genetics
H Abdel-Shafy, R H Bortfeldt, M Reissmann, G A Brockmann
A validation study for six genomic regions previously identified by a genome-wide association study for somatic cell score was conducted with data of clinical mastitis in German Holstein cattle. Out of 10 tested SNPs, five on chromosomes 6, 13 and 19 were significantly associated with clinical mastitis (P < 0.05). Three SNPs on chromosomes 6 and 19 had the same direction of effect as those previously reported in the initial genome-wide association study for somatic cell score. The other two SNPs on chromosome 13 had opposite effects...
January 4, 2018: Animal Genetics
Byeonghwi Lim, Amina Khatun, Sang-Wook Kim, Salik Nazki, Chang-Gi Jeong, Suna Gu, Jungjae Lee, Kyung-Tai Lee, Choi-Kyu Park, Sang-Myeong Lee, Won-Il Kim, Kwan-Suk Kim
No abstract text is available yet for this article.
December 28, 2017: Animal Genetics
G Farries, P A McGettigan, K F Gough, B A McGivney, D E MacHugh, L M Katz, E W Hill
Adaptation to early training and racing (i.e. precocity), which is highly variable in racing Thoroughbreds, has implications for the selection and training of horses. We hypothesised that precocity in Thoroughbred racehorses is heritable. Age at first sprint training session (work day), age at first race and age at best race were used as phenotypes to quantify precocity. Using high-density SNP array data, additive SNP heritability (hSNP2) was estimated to be 0.17, 0.14 and 0.17 for the three traits respectively...
December 12, 2017: Animal Genetics
J Chen, J Peng, Q Xiao, Y Pan, X Zhang, L J Lo, N Xu
Chinese indigenous pigs in Zhejiang Province are well known for their high fecundity. In order to verify breed subdivision at the genomic level, we investigated genetic diversity and population structure of seven breeds and made comparisons with three Western pig breeds using next-generation sequencing data. Parameters obtained from allelic richness and proportion of polymorphic markers indicated that the genetic diversity of the Chinese indigenous pigs was higher than that of the Western pigs, with the highest and lowest values found in the Chaluand and the Landrace pigs respectively...
December 1, 2017: Animal Genetics
W S Xin, F Zhang, G R Yan, W W Xu, S J Xiao, Z Y Zhang, L S Huang
A large proportion of gilts and sows are culled from reproduction populations because of anestrus and pubertal reproductive failure. Selecting early onset of puberty gilts has a favorable effect on sows' reproductivity. However, age at puberty is hard to be routinely measured in commercial herds. With molecular genetic predictors, identifying individuals that have a propensity for early onset of puberty can be simplified. We previously performed genome scanning and a genome-wide association study for puberty in an F2 resource population using 183 microsatellites and 62 125 SNPs respectively...
December 1, 2017: Animal Genetics
D He, Z Jiang, Y Tian, H Han, M Xia, W Wei, L Zhang, J Chen
Intramuscular fat (IMF) content is a key aspect of pork quality. Elucidation of intramuscular adipocyte regulation mechanisms is important for improving IMF content. Intramuscular adipocytes are dispersed among muscle fibers, so they are inclined to be affected by muscle-derived factors. Interleukin-15 is a major muscle-secreted factor. In this study, the genetic and physiological impacts of IL15 on adipogenesis is investigated. The promoter region of IL15 was scanned by comparative sequencing using two DNA pools of high- and low-IMF individuals...
November 22, 2017: Animal Genetics
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