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Animal Genetics

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https://www.readbyqxmd.com/read/28815638/new-insights-into-the-origin-and-the-genetic-status-of-the-balkan-donkey-from-serbia
#1
L J Stanisic, J M Aleksic, V Dimitrijevic, P Simeunovic, U Glavinic, J Stevanovic, Z Stanimirovic
The Balkan donkey (Equus asinus L.) is commonly regarded as a large-sized, unselected, unstructured and traditionally managed donkey breed. We assessed the current genetic status of the three largest E. asinus populations in the central Balkans (Serbia) by analysing the variability of nuclear microsatellites and the mitochondrial (mtDNA) control region of 77 and 49 individuals respectively. We further analysed our mtDNA dataset along with 209 published mtDNA sequences of ancient and modern individuals from 19 European and African populations to provide new insights into the origin and the history of the Balkan donkey...
August 16, 2017: Animal Genetics
https://www.readbyqxmd.com/read/28748545/underdominant-kcc3b-r31i-association-with-blood-sodium-concentration-in-domestic-sheep-suggests-role-in-oligomer-function
#2
Stephen N White, Ryan D Oliveira, Michelle R Mousel, Michael V Gonzalez, Margaret A Highland, Maria K Herndon, J Bret Taylor, Donald P Knowles
No abstract text is available yet for this article.
July 27, 2017: Animal Genetics
https://www.readbyqxmd.com/read/28748531/sri-lankan-pig-ancestry-revealed-by-mitochondrial-dna-y-chromosome-and-mc1r
#3
Nalini Yasoda Hirimuthugoda, Adeniyi C Adeola, Patthamesthrige Wimal Anthony Perera, Xing Chen, Weligalle Wedarallage Dewar Asoka Gunawardena, Humpita Gamaralalage Thilini Nisanka Gunawardana, Ting-Ting Yin, Ming-Shan Wang, Gui-Mei Li, Zhao-Li Ding, Wen-Zhi Wang, Hai-Bing Xie, Min-Sheng Peng, Ya-Ping Zhang
No abstract text is available yet for this article.
July 27, 2017: Animal Genetics
https://www.readbyqxmd.com/read/28741802/cytogenetic-tests-for-animal-production-state-of-the-art-and-perspectives
#4
REVIEW
I Udroiu, A Sgura
Cytogenetic tests are effective tools for monitoring the health status of livestock and improving their genetic value. Cytogenetic screening allows for the detection of animals carrying chromosomal aberrations and to avoid using them as breeders. Progress in karyotype monitoring, with new molecular probes and automation, has greatly increased the productivity of this procedure. Several genotoxicity tests are available to detect the possible presence and effects of pollutants or drugs. Among these, the micronucleus test and the Comet assay are the most convenient in terms of costs and benefits...
July 25, 2017: Animal Genetics
https://www.readbyqxmd.com/read/28741731/the-evolutionary-history-of-the-dmrt3-gait-keeper-haplotype
#5
E A Staiger, M S Almén, M Promerová, S Brooks, E G Cothran, F Imsland, K Jäderkvist Fegraeus, G Lindgren, H Mehrabani Yeganeh, S Mikko, J L Vega-Pla, T Tozaki, C J Rubin, L Andersson
A previous study revealed a strong association between the DMRT3:Ser301STOP mutation in horses and alternate gaits as well as performance in harness racing. Several follow-up studies have confirmed a high frequency of the mutation in gaited horse breeds and an effect on gait quality. The aim of this study was to determine when and where the mutation arose, to identify additional potential causal mutations and to determine the coalescence time for contemporary haplotypes carrying the stop mutation. We utilized sequences from 89 horses representing 26 breeds to identify 102 SNPs encompassing the DMRT3 gene that are in strong linkage disequilibrium with the stop mutation...
July 25, 2017: Animal Genetics
https://www.readbyqxmd.com/read/28737288/linkage-disequilibrium-among-commonly-genotyped-snp-variants-detected-from-bull-sequence
#6
W M Snelling, L A Kuehn, B N Keel, R M Thallman, G L Bennett
Genomic prediction utilizing causal variants could increase selection accuracy above that achieved with SNPs genotyped by currently available arrays used for genomic selection. A number of variants detected from sequencing influential sires are likely to be causal, but noticeable improvements in prediction accuracy using imputed sequence variant genotypes have not been reported. Improvement in accuracy of predicted breeding values may be limited by the accuracy of imputed sequence variants. Using genotypes of SNPs on a high-density array and non-synonymous SNPs detected in sequence from influential sires of a multibreed population, results of this examination suggest that linkage disequilibrium between non-synonymous and array SNPs may be insufficient for accurate imputation from the array to sequence...
July 24, 2017: Animal Genetics
https://www.readbyqxmd.com/read/28737247/a-single-base-deletion-in-the-slc45a2-gene-in-a-bullmastiff-with-oculocutaneous-albinism
#7
M Caduff, A Bauer, V Jagannathan, T Leeb
Oculocutaneous albinism type 4 (OCA4) in humans and similar phenotypes in many animal species are caused by variants in the SLC45A2 gene, encoding a putative sugar transporter. In dog, two independent SLC45A2 variants are known that cause oculocutaneous albinism in Doberman Pinschers and several small dog breeds respectively. For the present study, we investigated a Bullmastiff with oculocutaneous albinism. The affected dog was highly inbred and resulted from the mating of a sire to its own grandmother. We obtained whole genome sequence data from the affected dog and searched specifically for variants in candidate genes known to cause albinism...
July 24, 2017: Animal Genetics
https://www.readbyqxmd.com/read/28737243/investigating-the-genetic-regulation-of-the-expression-of-63-lipid-metabolism-genes-in-the-pig-skeletal-muscle
#8
R González-Prendes, R Quintanilla, M Amills
A comprehensive and systematic view of the genetic regulation of lipid metabolism genes is still lacking in pigs. Herewith, we have investigated the genetic regulation of 63 porcine genes with crucial roles in the uptake, transport, synthesis and catabolism of lipids. With this aim, we have performed an expression QTL (eQTL) scan in 104 pigs with available genotypes for the Illumina Porcine SNP60 chip and microarray measurements of gene expression in the gluteus medius muscle. Analysis of the data with gemma software revealed 13 cis- and 18 trans-eQTL modulating the expression of 19 loci...
July 24, 2017: Animal Genetics
https://www.readbyqxmd.com/read/28737212/a-genome-wide-association-study-for-equine-recurrent-airway-obstruction-in-european-warmblood-horses-reveals-a-suggestive-new-quantitative-trait-locus-on-chromosome-13
#9
D Schnider, S Rieder, T Leeb, V Gerber, M Neuditschko
Recurrent airway obstruction (RAO), also known as heaves, is an asthma-like respiratory disease. Its development is strongly influenced by environmental risk factors such as sensitization and exposure to moldy hay, straw bedding and stabling indoors. A hereditary component has been documented in previous studies; however, so far no causative genetic variant that influences the risk of developing RAO has been identified. In this study, we revised an existing dataset and selected 384 horses for genotyping on the Affymetrix high-density equine SNP array...
July 24, 2017: Animal Genetics
https://www.readbyqxmd.com/read/28736963/breeding-experiments-and-genome-wide-association-analysis-elucidate-two-genetically-different-forms-of-non-syndromic-congenital-cleft-lip-and-jaw-in-vorderwald%C3%A2-%C3%A3-%C3%A2-montb%C3%A3-liarde-cattle
#10
S Reinartz, O Distl
Non-syndromic congenital cleft lip and jaw (CLJ) is a condition reported in Vorderwald × Montbéliarde cattle. The objective of the present study was to perform a genome-wide association study (GWAS) for 10 CLJ-affected and 50 unaffected Vorderwald × Montbéliarde cattle using the bovine Illumina high density bead chip to identify loci for this condition. Phenotypic classification of CLJ was based on a detailed recording of orofacial structures using computed tomography. A breeding experiment among CLJ-affected Vorderwald × Montbéliarde cattle and CLJ-affected Vorderwald × Montbéliarde cattle with unaffected Holsteins confirmed recessive inheritance and different loci for bilateral or left-sided versus right-sided CLJ...
July 24, 2017: Animal Genetics
https://www.readbyqxmd.com/read/28736898/identification-of-positive-selection-signatures-in-pigs-by-comparing-linkage-disequilibrium-variances
#11
X Li, S Yang, K Dong, Z Tang, K Li, B Fan, Z Wang, B Liu
Selection affects the patterns of linkage disequilibrium (LD) around the site of a beneficial allele with an increase in LD among the hitchhiking alleles. Comparing the differences in regional LD between pig populations could help to identify putative genomic regions with potential adaptations for economic traits. In this study, using Illumina Porcine SNP60K BeadChip genotyping data from 207 Chinese indigenous, 117 South American village and 408 Large White pigs, we estimated the variation of genome-wide LD between populations using the varld program...
July 23, 2017: Animal Genetics
https://www.readbyqxmd.com/read/28703336/a-genome-wide-association-study-reveals-candidate-genes-for-the-supernumerary-nipple-phenotype-in-sheep-ovis-aries
#12
W-F Peng, S-S Xu, X Ren, F-H Lv, X-L Xie, Y-X Zhao, M Zhang, Z-Q Shen, Y-L Ren, L Gao, M Shen, J Kantanen, M-H Li
Genome-wide association studies (GWASs) have been widely applied in livestock to identify genes associated with traits of economic interest. Here, we conducted the first GWAS of the supernumerary nipple phenotype in Wadi sheep, a native Chinese sheep breed, based on Ovine Infinium HD SNP BeadChip genotypes in a total of 144 ewes (75 cases with four teats, including two normal and two supernumerary teats, and 69 control cases with two teats). We detected 63 significant SNPs at the chromosome-wise threshold. Additionally, one candidate region (chr1: 170...
July 12, 2017: Animal Genetics
https://www.readbyqxmd.com/read/28703288/a-comparative-proteomic-analysis-of-blood-serum-for-developmental-stages-in-pigs
#13
K Srikanth, E Lee, A Kwon, J Shin, H Chung
This study aimed to differentiate genes at developmental stages of pigs from 0 to 150 days of age, to build up a protein database and to find candidate genetic markers for growth traits. The analysis of two-dimensional electrophoresis and matrix-assisted laser-desorption/ionization mass spectrometry separated 252 protein segments. After successfully blasting the peptide sequences, the analysis confirmed 37 differentially expressed proteins that increased from birth to 150 days of age (type A), whereas the type B proteins presented the inverse pattern...
July 12, 2017: Animal Genetics
https://www.readbyqxmd.com/read/28699279/a-new-dominant-haplotype-of-mc1r-gene-in-chinese-black-plumage-chicken
#14
Gong-Wei Zhang, Yonglan Liao, Wen-Xiu Zhang, Yuhui Wu, Anfang Liu
No abstract text is available yet for this article.
July 11, 2017: Animal Genetics
https://www.readbyqxmd.com/read/28699276/y-chromosome-and-mtdna-variation-confirms-independent-domestications-and-directional-hybridization-in-south-american-camelids
#15
J C Marín, K Romero, R Rivera, W E Johnson, B A González
Investigations of genetic diversity and domestication in South American camelids (SAC) have relied on autosomal microsatellite and maternally-inherited mitochondrial data. We present the first integrated analysis of domestic and wild SAC combining male and female sex-specific markers (male specific Y-chromosome and female-specific mtDNA sequence variation) to assess: (i) hypotheses about the origin of domestic camelids, (ii) directionality of introgression among domestic and/or wild taxa as evidence of hybridization and (iii) currently recognized subspecies patterns...
July 11, 2017: Animal Genetics
https://www.readbyqxmd.com/read/28677334/genome-wide-association-analysis-identifies-the-genetic-basis-of-fat-deposition-in-the-tails-of-sheep-ovis-aries
#16
S-S Xu, X Ren, G-L Yang, X-L Xie, Y-X Zhao, M Zhang, Z-Q Shen, Y-L Ren, L Gao, M Shen, J Kantanen, M-H Li
Fat-tailed sheep (Ovis aries) can survive in harsh environments and satisfy human's intake of dietary fat. However, the animals require more feed, which increases the cost of farming. Thus, most farmers currently prefer thin-tailed, short-tailed or docked sheep. To date, the molecular mechanism of the formation of fat tails in sheep has not been completely elucidated. Here, we conducted a genome-wide association study using phenotypes and genotypes (the Ovine Infinium HD SNP BeadChip genotype data) of two breeds of contrasting tail types (78 Small-tailed and 78 Large-tailed Han sheep breeds) to identify functional genes and variants associated with fat deposition...
July 4, 2017: Animal Genetics
https://www.readbyqxmd.com/read/28639704/genome-wide-association-analysis-identifies-potential-regulatory-genes-for-eumelanin-pigmentation-in-chicken-plumage
#17
L Yang, X Du, S Wei, L Gu, N Li, Y Gong, S Li
Plumage color in chicken is determined by the proportion of eumelanin and pheomelanin pigmentation. As the main ingredient in plumage melanin, eumelanin plays a key role in the dark black, brown and grey coloration. However, very few studies have been performed to identify the related genes and mutations on a genome-wide scale. Herein, a resource family consisting of one backcross population and two F2 cross populations between a black roster and Yukou Brown I parent stockbreed was constructed for identification of genes related to eumelanin pigmentation...
June 22, 2017: Animal Genetics
https://www.readbyqxmd.com/read/28568904/mitochondrial-dna-analysis-of-ancient-sheep-from-altai
#18
M A Dymova, A V Zadorozhny, O V Mishukova, E A Khrapov, A S Druzhkova, V A Trifonov, I G Kichigin, A A Tishkin, S P Grushin, M L Filipenko
A comparative analysis of the genetic diversity of ancient and modern sheep can shed light on the origin of these animals and their distribution as well as help to evaluate the role of humans at each formation stage of different sheep breeds. Here we isolated ancient DNA and performed sequencing of the mitochondrial DNA D-loop from 17 sheep bone remains (~4000-1000 years old) found in the archaeological complexes in the south of Altai (Western Siberia). The length of the sequences obtained ranged between 318 and 586 bp...
May 31, 2017: Animal Genetics
https://www.readbyqxmd.com/read/28696026/a-genome-wide-association-study-for-a-proxy-of-intermuscular-fat-level-in-the-italian-large-white-breed-identifies-genomic-regions-affecting-an-important-quality-parameter-for-dry-cured-hams
#19
L Fontanesi, G Schiavo, G Galimberti, S Bovo, V Russo, M Gallo, L Buttazzoni
Intermuscular fat content in protected designations of origin dry-cured hams is a very important meat quality trait that affects the acceptability of the product by the consumers. An excess in intermuscular fat (defined as the level of fat deposition between leg muscles) is a defect that depreciates the final product. In this study we carried out a genome-wide association study for visible intermuscular fat (VIF) of hams in the Italian Large White pig breed. This trait was evaluated on the exposed muscles of green legs in 1122 performance-tested gilts by trained personnel, according to a classification scale useful for routine and cheap evaluation...
August 2017: Animal Genetics
https://www.readbyqxmd.com/read/28696025/a-novel-vwf-variant-associated-with-type-2-von-willebrand-disease-in-german-wirehaired-pointers-and-german-shorthaired-pointers
#20
M Vos-Loohuis, B A van Oost, C Dangel, I Langbein-Detsch, P A Leegwater
Von Willebrand disease (VWD), caused by deficiency of the von Willebrand factor (VWF), is the most common bleeding disorder in humans and dogs. The complete cDNA encoding VWF of a German Wirehaired Pointer with type 2 VWD was sequenced, and we found four variants that alter the amino acid sequence. These variants were: c.1657T>G corresponding to p.Trp553Gly; c.1777G>A (p.Glu593Lys); c.4937A>G (p.Asn1646Ser) and c.5544G>A (p.Met1848Ile). A haplotype of the c.1657G, c.1777A and c.4937G alleles co-segregated with the VWF antigen level in a four-generation pedigree with the disease...
August 2017: Animal Genetics
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