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Disease Markers

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https://www.readbyqxmd.com/read/27890964/association-of-the-mdm2-snp285-polymorphism-with-cancer-susceptibility-a-meta-analysis
#1
REVIEW
Ping Wang, Meilin Wang, Sanqiang Li, Lingjun Ma, Shoumin Xi, Jing He
The mouse double minute 2 (MDM2) gene encodes a negative regulator for p53, and the polymorphism SNP285 in the promoter region of MDM2 gene has been implicated in cancer risk, but individual published studies had inconclusive results. Therefore, we performed this meta-analysis to obtain a more precise estimation between MDM2 SNP285 polymorphism and risk of cancer. A systematic literature search was performed using the PubMed, Embase, and Chinese Biomedical (CBM) databases. Ultimately, 16 published studies comprising 14,573 cases and 9,115 controls were included...
2016: Disease Markers
https://www.readbyqxmd.com/read/27881889/expression-of-caf-related-proteins-is-associated-with-histologic-grade-of-breast-phyllodes-tumor
#2
Hye Min Kim, Yu Kyung Lee, Ja Seung Koo
Purpose. The purpose of this study was to investigate the expression of cancer-associated fibroblast- (CAF-) related proteins and the implications in breast phyllodes tumor (PT). Methods. Tissue microarrays of 194 PT cases (151 benign PT, 27 borderline PT, and 16 malignant PT) were constructed. We performed immunohistochemical staining for CAF-related proteins (podoplanin, prolyl 4-hydroxylase, FAPα, S100A4, PDGFR α/β, and NG2) and analyzed the results according to clinicopathologic parameters. Results. Expression of PDGFRα and PDGFRβ in the stromal component increased with increasing histologic grade of PT (p = 0...
2016: Disease Markers
https://www.readbyqxmd.com/read/27881888/effects-of-ramipril-and-telmisartan-on-plasma-concentrations-of-low-molecular-weight-and-protein-thiols-and-carotid-intima-media-thickness-in-patients-with-chronic-kidney-disease
#3
Angelo Zinellu, Salvatore Sotgia, Arduino A Mangoni, Elisabetta Sotgiu, Sara Ena, Dionigia Arru, Stefano Assaretti, Angela Baralla, Andrea E Satta, Ciriaco Carru
Hypertension, a common feature in chronic kidney disease (CKD), is an independent risk factor for CKD progression and cardiovascular disease. Although inhibitors of the renin-angiotensin system (RAS) exert salutary effects on blood pressure control and proteinuria in CKD patients, their activity towards traditional and novel oxidative markers is largely unknown. We studied the effects of 6-month treatment with telmisartan versus a combination of telmisartan and ramipril on plasma concentrations of low molecular mass (LMW, including homocysteine and cysteine) and protein thiols (PSH) plasma concentration and their relationships with carotid intima media thickness (IMT), in 24 hypertensive CKD patients (age 60 ± 12 years, 8 females and 16 males)...
2016: Disease Markers
https://www.readbyqxmd.com/read/27872510/association-of-the-aspartate-aminotransferase-to-alanine-aminotransferase-ratio-with-bnp-level-and-cardiovascular-mortality-in-the-general-population-the-yamagata-study-10-year-follow-up
#4
Miyuki Yokoyama, Tetsu Watanabe, Yoichiro Otaki, Hiroki Takahashi, Takanori Arimoto, Tetsuro Shishido, Takuya Miyamoto, Tsuneo Konta, Yoko Shibata, Makoto Daimon, Yoshiyuki Ueno, Takeo Kato, Takamasa Kayama, Isao Kubota
Background. Early identification of high risk subjects for cardiovascular disease in health check-up is still unmet medical need. Cardiovascular disease is characterized by the superior increase in aspartate aminotransferase (AST) to alanine aminotransferase (ALT). However, the association of AST/ALT ratio with brain natriuretic peptide (BNP) levels and cardiovascular mortality remains unclear in the general population. Methods and Results. This longitudinal cohort study included 3,494 Japanese subjects who participated in a community-based health check-up, with a 10-year follow-up...
2016: Disease Markers
https://www.readbyqxmd.com/read/27872509/diagnostic-utility-of-ang-in-coronary-heart-disease-complicating-chronic-heart-failure-a-cross-sectional-study
#5
Peng Yu, Ming Liu, Xue Yang, Ying Yu, Ji Zhao, Lei Zhang, Rui Tong, Hong Jiang, Yunzeng Zou, Junbo Ge
Angiogenin (ANG) has been shown to be elevated in several cardiovascular diseases. To detect its levels and diagnostic capacity in coronary heart disease (CHD) patients complicating chronic heart failure (CHF), we performed this cross-sectional study and enrolled 616 CHD patients and 53 healthy controls. According to complicating CHF or not, the patients were divided into CHF group (n = 203) and CHD disease controls (n = 413), in which the CHF group was subdivided as heart failure with reduced ejection fraction (HFrEF) group or heart failure with preserved ejection fraction (HFpEF) group on the basis of left ventricular ejection fraction (LVEF), or as different NYHA class group...
2016: Disease Markers
https://www.readbyqxmd.com/read/27867249/elevated-omentin-serum-levels-predict-long-term-survival-in-critically-ill-patients
#6
Mark Luedde, Fabian Benz, Jennifer Niedeggen, Mihael Vucur, Hans-Joerg Hippe, Martina E Spehlmann, Florian Schueller, Sven Loosen, Norbert Frey, Christian Trautwein, Alexander Koch, Tom Luedde, Frank Tacke, Christoph Roderburg
Introduction. Omentin, a recently described adipokine, was shown to be involved in the pathophysiology of inflammatory and infectious diseases. However, its role in critical illness and sepsis is currently unknown. Materials and Methods. Omentin serum concentrations were measured in 117 ICU-patients (84 with septic and 33 with nonseptic disease etiology) admitted to the medical ICU. Results were compared with 50 healthy controls. Results. Omentin serum levels of critically ill patients at admission to the ICU or after 72 hours of ICU treatment were similar compared to healthy controls...
2016: Disease Markers
https://www.readbyqxmd.com/read/27847402/autoantibody-response-to-zrf1-and-krr1-serex-antigens-in-patients-with-breast-tumors-of-different-histological-types-and-grades
#7
Lada Dyachenko, Kristina Havrysh, Anita Lytovchenko, Irina Dosenko, Stepan Antoniuk, Valeriy Filonenko, Ramziya Kiyamova
Purpose. To investigate a frequency of antibody response to SEREX-identified medullary breast carcinoma autoantigens ZRF1 and KRR1 in sera of breast cancer patients taking into account clinical and molecular characteristics of tumors for opening of new perspectives in creation of minimally invasive immunological tests for cancer diagnostics. Methods. Enzyme-linked immunosorbent assay and bioinformatics analysis. Results. Increased frequency of antibody response was found in sera of breast cancer patients to ZRF and KRR1 antigens...
2016: Disease Markers
https://www.readbyqxmd.com/read/27843174/omics-landscape-in-disease-biomarkers-discovery
#8
EDITORIAL
Monica Neagu, Caterina Longo, Simone Ribero
No abstract text is available yet for this article.
2016: Disease Markers
https://www.readbyqxmd.com/read/27843173/pilot-study-on-mage-c2-as-a-potential-biomarker-for-triple-negative-breast-cancer
#9
Qian Zhao, Wen-Ting Xu, Tuluhong Shalieer
Objective. In the current study, we measured the expression status of melanoma antigen gene c2 (MAGE-C2) in triple-negative breast cancer (TNBC) and analyzed its prognostic with the clinical pathological features of patients with TNBC. Methods. The expressions statuses of MAGE-C2 were detected in TNBC tissues and paracarcinoma tissues by immunohistochemistry, reverse transcription-polymerase chain reaction (RT-PCR), and western blotting. Then, we investigated the relationship of MAGE-C2 expression status and clinicopathological parameters of TNBC patients by the chi-squared test...
2016: Disease Markers
https://www.readbyqxmd.com/read/27829696/plasma-levels-of-pentosidine-carboxymethyl-lysine-soluble-receptor-for-advanced-glycation-end-products-and-metabolic-syndrome-the-metformin-effect
#10
Mohamed Haddad, Ines Knani, Hsan Bouzidi, Olfa Berriche, Mohamed Hammami, Mohsen Kerkeni
Metabolic syndrome (MetS) is considered one of the most important public health problems. Several and controversial studies showed that the role of advanced glycation end products (AGEs) and their receptor in the development of metabolic syndrome and therapeutic pathways is still unsolved. We have investigated whether plasma pentosidine, carboxymethyl-lysine (CML), and soluble receptor for advanced glycation end products (sRAGE) levels were increased in patients with MetS and the effect of metformin in plasma levels of pentosidine, CML, and sRAGE...
2016: Disease Markers
https://www.readbyqxmd.com/read/27821903/proteomic-approaches-to-biomarker-discovery-in-cutaneous-t-cell-lymphoma
#11
REVIEW
Alexandra Ion, Iris Maria Popa, Laura Maria Lucia Papagheorghe, Cristina Lisievici, Mihai Lupu, Vlad Voiculescu, Constantin Caruntu, Daniel Boda
Cutaneous T-cell lymphoma (CTCL) is the most frequently encountered type of skin lymphoma in humans. CTCL encompasses multiple variants, but the most common types are mycosis fungoides (MF) and Sezary syndrome (SS). While most cases of MF run a mild course over a period of many years, other subtypes of CTCL are very aggressive. The rapidly expanding fields of proteomics and genomics have not only helped increase knowledge concerning the carcinogenesis and tumor biology of CTCL but also led to the discovery of novel markers for targeted therapy...
2016: Disease Markers
https://www.readbyqxmd.com/read/27821902/rantes-gene-polymorphisms-associated-with-hiv-1-infections-in-kenyan-population
#12
Shem P M Mutuiri, Helen L Kutima, Lamech M Mwapagha, James K Munyao, Anthony Kebira Nyamache, Irene Wanjiru, Samoel A Khamadi
Previous studies have reported that two single nucleotide polymorphisms (SNPs) in the RANTES gene promoter region, -403G/A and -28C/G, are associated with a slower rate of decline in CD4+ T cell count. In addition, as a ligand of the major HIV coreceptor CCR5, it is known to block HIV-CCR5 interactions in the course of the HIV infection cycle. This study was carried out with the aim of determining the occurrence of single nucleotide polymorphisms (SNPs) -403G > A and -28C > G in the promoter region of RANTES, in a subset of the Kenyan population...
2016: Disease Markers
https://www.readbyqxmd.com/read/27818568/redox-status-of-%C3%AE-2gpi-in-different-stages-of-diabetic-angiopathy
#13
Jun Ma, Jing-Yun Zhang, Yan Liu, De-Min Yu, Pei Yu
We explored the redox status of beta 2 glycoprotein I (β2GPI) in different stages of diabetic angiopathy. Type 2 diabetes mellitus (T2DM) had a significantly lower proportion of reduced β2GPI as compared to healthy controls (p < 0.05). There was a trend that the mild coronal atherosclerosis heart disease (CAD) had higher proportion of reduced β2GPI than non-CAD and severe-CAD groups, however without significances (p > 0.05). The mild-A-stenosis group and mild-diabetic retinopathy (DR) groups had higher proportion of reduced β2GPI than their severely affected counterparts...
2016: Disease Markers
https://www.readbyqxmd.com/read/27818567/the-hasford-score-may-predict-molecular-response-in-chronic-myeloid-leukemia-patients-a-single-institution-experience
#14
Jarosław Dybko, Bożena Jaźwiec, Olga Haus, Donata Urbaniak-Kujda, Katarzyna Kapelko-Słowik, Tomasz Wróbel, Tomasz Lonc, Mateusz Sawicki, Ewa Mędraś, Agnieszka Kaczmar-Dybko, Kazimierz Kuliczkowski
The Sokal, Hasford, and EUTOS scores were established in different treatment eras of chronic myeloid leukemia (CML). None of them was reported to predict molecular response. In this single center study we tried to reevaluate the usefulness of three main scores in TKI era. The study group included 88 CML patients in first chronic phase treated initially with standard imatinib dose. All of them achieved major molecular response (MMR) in time points defined by European LeukemiaNet (ELN). 42 patients lost MMR in a median time of 47 months and we found a significant difference in MMR maintenance between intermediate-risk (IR) and low-risk (LR) patients assessed by Hasford score...
2016: Disease Markers
https://www.readbyqxmd.com/read/27818566/overexpression-of-prolyl-4-hydroxylase-%C3%AE-1-stabilizes-but-increases-shear-stress-induced-atherosclerotic-plaque-in-apolipoprotein-e-deficient-mice
#15
Xiao-Qing Cao, Xin-Xin Liu, Meng-Meng Li, Yu Zhang, Liang Chen, Lin Wang, Ming-Xue Di, Mei Zhang
The rupture and erosion of atherosclerotic plaque can induce coronary thrombosis. Prolyl-4-hydroxylase (P4H) plays a central role in the synthesis of all known types of collagens, which are the most abundant constituent of the extracellular matrix in atherosclerotic plaque. The pathogenesis of atherosclerosis is thought to be in part caused by shear stress. In this study, we aimed to investigate a relationship between P4Hα1 and shear stress-induced atherosclerotic plaque. Carotid arteries of ApoE-/- mice were exposed to low and oscillatory shear stress conditions by the placement of a shear stress cast for 2 weeks; we divided 60 male ApoE-/- mice into three groups for treatments with saline (mock) (n = 20), empty lentivirus (lenti-EGFP) (n = 20), and lentivirus-P4Hα1 (lenti-P4Hα1) (n = 20)...
2016: Disease Markers
https://www.readbyqxmd.com/read/27803511/survivin-as-a-novel-biomarker-in-the-pathogenesis-of-acne-vulgaris-and-its-correlation-to-insulin-like-growth-factor-i
#16
Hanan A Assaf, Wafaa M Abdel-Maged, Bakheet E M Elsadek, Mohammed H Hassan, Mohamed A Adly, Soher A Ali
Survivin, a member of the inhibitor of apoptosis protein family, has an important role in cell cycle regulation. Insulin-like growth factor-I (IGF-I) is a polypeptide hormone with wide range of biologic effects including stimulation of lipogenesis in sebaceous glands. Their overexpression in some fibrotic disorders suggests a possible implication of both IGF-I and survivin in the pathogenesis of acne and/or acne scars. The current study aimed to assess and correlate serum levels of IGF-I and survivin in patients with active acne vulgaris and postinflammatory acne scars and to evaluate their lesional expressions in comparison to healthy controls...
2016: Disease Markers
https://www.readbyqxmd.com/read/27799660/toward-noninvasive-diagnosis-of-iga-nephropathy-a-pilot-urinary-metabolomic-and-proteomic-study
#17
Michaela Neprasova, Dita Maixnerova, Jan Novak, Colin Reily, Bruce A Julian, Jan Boron, Petr Novotny, Miloslav Suchanek, Vladimir Tesar, Petr Kacer
IgA nephropathy is diagnosed by renal biopsy, an invasive procedure with a risk of significant complications. Noninvasive approaches are needed for possible diagnostic purposes and especially for monitoring disease activity or responses to treatment. In this pilot project, we assessed the utility of urine samples as source of biomarkers of IgA nephropathy. We used spot urine specimens from 19 healthy controls, 11 patients with IgA nephropathy, and 8 renal-disease controls collected on day of renal biopsy. Urine samples were analyzed using untargeted metabolomic and targeted proteomic analyses by several experimental techniques: liquid chromatography coupled with mass spectrometry, immunomagnetic isolation of target proteins coupled with quantitation by mass spectrometry, and protein arrays...
2016: Disease Markers
https://www.readbyqxmd.com/read/27795608/cytokine-profile-in-chronic-periodontitis-patients-with-and-without-obesity-a-systematic-review-and-meta-analysis
#18
REVIEW
Zohaib Akram, Tariq Abduljabbar, Mohamed Ibrahim Abu Hassan, Fawad Javed, Fahim Vohra
To investigate the cytokine profile as biomarkers in the gingival crevicular fluid (GCF) of chronic periodontitis (CP) patients with and without obesity, MEDLINE/PubMed, EMBASE, ScienceDirect, and SCOPUS databases were combined with handsearching of articles published from 1977 up to May 2016 using relevant MeSH terms. Meta-analyses were conducted separately for each of the cytokines: resistin, adiponectin, TNF-α, leptin, IL-6, IL-8, and IL-1β. Forest plots were produced reporting standardized mean difference of outcomes and 95% confidence intervals...
2016: Disease Markers
https://www.readbyqxmd.com/read/27795607/diagnostic-and-prognostic-markers-in-bladder-cancer
#19
EDITORIAL
Ja Hyeon Ku, Wun-Jae Kim, Seth P Lerner, Felix Chun, Luis Alex Kluth
No abstract text is available yet for this article.
2016: Disease Markers
https://www.readbyqxmd.com/read/27777493/mir-1-inhibits-cell-growth-migration-and-invasion-by-targeting-vegfa-in-osteosarcoma-cells
#20
Junjie Niu, Yibao Sun, Qiaoge Guo, Dongju Niu, Bo Liu
microRNAs (miRNAs) are small noncoding RNAs and have been shown to play a crucial role in the osteosarcoma (OS) tumorigenesis and progression. VEGFA is a key regulator of angiogenesis and plays an important role in regulation of tumor metastasis. The objective of this study was to determine whether VEGFA was involved in miR-1-mediated suppression of proliferation, migration, and invasion of OS cells. The expression levels of miR-1 were significantly lower in OS tumor tissues than those in adjacent normal tissues and in SAOS-2 and U2OS cell lines compared to a normal osteoblast (NHOst) cell line...
2016: Disease Markers
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