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Disease Markers

Rama Jayaraj, Chellan Kumarasamy, Madurantakam Royam Madhav, Venkatesh Pandey, Shanthi Sabarimurugan, N Ramesh, K M Gothandam, Siddhartha Baxi
No abstract text is available yet for this article.
2018: Disease Markers
Ting-Ting Tian, Hui Li, Sheng-Jie Chen, Qing Wang, Qing-Wu Tian, Bei-Bei Zhang, Jie Zhu, Guo-Wei He, Li-Min Lun, Chao Xuan
Serum uric acid (UA) is the final product of purine metabolism in humans. The present study is aimed at identifying the potential association between serum UA and early-onset coronary artery disease (EOCAD). The study population consisted of 1093 EOCAD patients aged ≤50 years, and 1117 age- and sex-matched apparently healthy people served as controls. The concentrations of UA were measured by uricase method. The severity of CAD was evaluated by Gensini score. The mean serum level of UA was 5.843 ± 1...
2018: Disease Markers
Liyan Hou, Yingbo Li, Ying Wang, Dongqiang Xu, Hailing Cui, Xiaoyan Xu, Ying Cong, Chengyong Yu
In this study, we investigated the potential prognostic value of ubiquitin-conjugating enzyme E2D1 ( UBE2D1 ) RNA expression in different histological subtypes of non-small-cell lung cancer (NSCLC). A retrospective study was performed by using molecular, clinicopathological, and survival data in the Cancer Genome Atlas (TCGA)-Lung Cancer. Results showed that both lung adenocarcinoma (LUAD) ( N = 514) and lung squamous cell carcinoma (LUSC) ( N = 502) tissues had significantly elevated UBE2D1 RNA expression compared to the normal tissues ( p < 0...
2018: Disease Markers
Kadir Harmanci, Ozden Yildirim Akan, Timur Pirildar, Pinar Ortan, Cevval Ulman
Background: There is no specific marker that shows the disease activity in Behçet's disease. Aim: In this study, we aimed to investigate VEGF-B and VEGF gene expressions and sTREM-1 levels in association with the activation of Behçet's disease. Study Design: Case-control study. Methods: Clinical features of patients who applied in the rheumatology clinic and were diagnosed with BD according to the international working group's criteria were investigated...
2018: Disease Markers
Meng-Jun Qiu, Yao-Bing Chen, Ning-Rui Bi, Sheng-Li Yang, Xiao-Xiao He, Zhi-Fan Xiong
Purpose: The objective of this study was to analyze the clinical features and prognosis of gastroenteropancreatic (GEP) neuroendocrine carcinomas (NECs) with liver metastasis and primary hepatic neuroendocrine carcinomas (PHNECs), as these rare hepatic neuroendocrine carcinomas have not been exhaustively studied. Methods: The clinical data of 47 patients with hepatic NECs were retrospectively reviewed and categorized to analyze features and prognosis. Results: The 47 studied cases comprised 13 cases of primary hepatic NECs (primary group) and 34 cases of metastatic hepatic NECs (metastatic group)...
2018: Disease Markers
Pan-Pan Liu, Yi Xia, Xi-Wen Bi, Yu Wang, Peng Sun, Hang Yang, Zhi-Ming Li, Wen-Qi Jiang
Treatment modalities for primary gastric diffuse large B-cell lymphoma (PG-DLBCL) have changed significantly during the past decades. However, limited information on the trends of clinical outcome of PG-DLBCL patients has been reported. Here, we conducted a retrospective analysis using the Surveillance, Epidemiology, and End Results (SEER) database to compare the survival trends of PG-DLBCL patients from 1973 to 2014. Patients were divided into 2 eras based on the year of diagnosis in relation to immunotherapy with the anti-CD20 antibody rituximab that was approved in 1997 and became a widely used drug in 2000...
2018: Disease Markers
Raymundo Cassani, Mar Estarellas, Rodrigo San-Martin, Francisco J Fraga, Tiago H Falk
Alzheimer's disease (AD) is a neurodegenerative disorder that accounts for nearly 70% of the more than 46 million dementia cases estimated worldwide. Although there is no cure for AD, early diagnosis and an accurate characterization of the disease progression can improve the quality of life of AD patients and their caregivers. Currently, AD diagnosis is carried out using standardized mental status examinations, which are commonly assisted by expensive neuroimaging scans and invasive laboratory tests, thus rendering the diagnosis time consuming and costly...
2018: Disease Markers
Yanping Chen, Yanping Li, Na Li, Xiude Fan, Chunyan Li, Pingping Zhang, Qunying Han, Zhengwen Liu
Noninvasive fibrosis tests are highly needed but have not been well studied in chronic hepatitis B patients with normal or minimally elevated alanine aminotransferase (ALT) levels. This study is aimed at developing a noninvasive score system to predict liver fibrosis in these patients. HBeAg-positive chronic hepatitis B patients with ALT levels of <80 IU/l and liver histology ( n = 290) were assigned to training ( n = 203) or validation ( n = 87) groups. Training group patients were divided into nonsignificant (F0-1) and significant fibrosis (F2-4) according to METAVIR stages...
2018: Disease Markers
Chao-Hung Wang, Mei-Ling Cheng, Min-Hui Liu
Metabolic disturbances represent functional perturbation in peripheral tissues and predict outcomes in patients with heart failure (HF). This study developed an amino acid-based metabolic panel and sought to see whether this panel could add diagnostic and prognostic value to currently used B-type natriuretic peptide (BNP) measurements. Mass spectrometry and ultra-performance liquid chromatography were performed on 1288 participants, including 129 normal controls and 712 patients at HF stages A to D in the initial cohort and 447 stage C patients in the validation cohort...
2018: Disease Markers
Larisa-Diana Mocan Hognogi, Cerasela-Mihaela Goidescu, Anca-Daniela Farcaş
Cardiovascular disease is the leading cause of death among both women and men, but there is still a great percentage of misdiagnosis and lack of clearly defined criteria. Advances in biomolecular science have proven the crucial role of inflammation and, more importantly, the role of adipokines in mediating all stages of coronary artery disease. It has also been suggested that regional fat deposits, more precisely from thoracic region, have a major influence on the development of coronary artery disease by creating a local proatherogenic environment...
2018: Disease Markers
Rong-Xin Geng, Ning Li, Yang Xu, Jun-Hui Liu, Fan-En Yuan, Qian Sun, Bao-Hui Liu, Qian-Xue Chen
Glioma is the most common neoplasm of the central nervous system (CNS); the progression and outcomes of which are affected by a complicated network of genes and pathways. We chose a gene expression profile of GSE66354 from GEO database to search core biomarkers during the occurrence and development of glioma. A total of 149 samples, involving 136 glioma and 13 normal brain tissues, were enrolled in this article. 1980 differentially expressed genes (DEGs) including 697 upregulated genes and 1283 downregulated genes between glioma patients and healthy individuals were selected using GeoDiver and GEO2R tool...
2018: Disease Markers
Maria Teresa Gonzalez-Garza, Hector Ramon Martinez, Delia E Cruz-Vega, Martin Hernandez-Torre, Jorge E Moreno-Cuevas
Amyotrophic lateral sclerosis (ALS) is an aggressive neurodegenerative disorder that selectively attacks motor neurons in the brain and spinal cord. Despite important advances in the knowledge of the etiology and progression of the disease, there are still no solid grounds in which a clinician could make an early objective and reliable diagnosis from which patients could benefit. Diagnosis is difficult and basically made by clinical rating scales (ALSRs and El Escorial). The possible finding of biomarkers to aid in the early diagnosis and rate of disease progression could serve for future innovative therapeutic approaches...
2018: Disease Markers
Ding Li, Yan Sun, Xiaochao Kong, Changxing Luan, Youjia Yu, Feng Chen, Peng Chen
ARHGEF18 has been identified as upregulated in the lung tissues of rat models of pulmonary artery hypertension introduced by hypoxia or monocrotaline (MCT). We used online SNP function prediction tools to screen the candidate SNPs that might be associated with the regulation of the ARHGEF18 expression. The result suggested that rs3745357 located in the 3'-untranslated region of ARHGEF18 is probably a genetic modifier in the process. In the present study, we aimed to investigate the association between ARHGEF18 rs3745357 polymorphism and nonidiopathic pulmonary arterial hypertension susceptibility (niPAH)...
2018: Disease Markers
Hao Sun, Donghui Huang, Hailong Wang, Bo Zhou, Xiaomei Wu, Bing Ma, Jingpu Shi
Background: Copeptin has been implicated as an effective prognostic biomarker of stroke outcome; however, few studies have investigated whether copeptin could be used as an etiological factor for stroke or not. The aim of our study was to evaluate the association of serum copeptin with stroke. Methods: In total, 238 participants including 119 cases (87 ischemic stroke and 32 hemorrhagic stroke) and 119 controls were included in this 1 : 1 matched case-control study...
2018: Disease Markers
Jiu Chen, Guolin Wu, Youdi Li
Aim: To explore the diagnostic efficacy of des-gamma-carboxy prothrombin (DCP) in hepatitis B virus- (HBV-) related hepatocellular carcinoma (HCC). Methods: A retrospective study of 459 cases from June 2016 to March 2018 was undertaken, and records of the DCP levels were extracted. The sensitivity, specificity, and cutoff points were calculated using SPSS 17.0 software. A systematic search in PubMed, Web of Science, and the Cochrane Central Register of Controlled Trials was performed for articles published in English from 1997 to 2017, focusing on serum DCP for HBV-related HCC...
2018: Disease Markers
Julie Bienertova-Vasku, Manlio Vinciguerra, Marek Buzga, Francesc Villaroya
No abstract text is available yet for this article.
2018: Disease Markers
Maria Luisa Tataranno, Serafina Perrone, Mariangela Longini, Caterina Coviello, Maria Tassini, Antonio Vivi, Marco Calderisi, Linda S deVries, Floris Groenendaal, Giuseppe Buonocore, Manon J N L Benders
Background and Objective: Early identification of neonates at risk for brain injury is important to start appropriate intervention. Urinary metabolomics is a source of potential, noninvasive biomarkers of brain disease. We studied the urinary metabolic profile at 2 and 10 days in preterm neonates with normal/mild and moderate/severe MRI abnormalities at term equivalent age. Methods: Urine samples were collected at two and 10 days after birth in 30 extremely preterm infants and analyzed using proton magnetic resonance spectroscopy...
2018: Disease Markers
Qixian Yang, Ping Zhang, Rongqiang Wu, Kefeng Lu, Hongxing Zhou
The detection of serum biomarkers can aid in the diagnosis of lung cancer. In recent years, an increasing number of lung cancer markers have been identified, and these markers have been reported to have varying diagnostic values. A method to compare the diagnostic value of different combinations of biomarkers needs to be established to identify the best combination. In this study, automatic chemiluminescence analyzers were employed to detect the serum concentrations of carcinoembryonic antigen (CEA), carbohydrate antigen 125 (CA125), cytokeratin 19 fragment (CY211), neuron-specific enolase (NSE), and squamous cell carcinoma antigen (SCC) in 780 healthy subjects, 650 patients with pneumonia, and 633 patients with lung cancer...
2018: Disease Markers
Di Che, Lei Pi, Zhenzhen Fang, Yufen Xu, Minmin Cai, Lanyan Fu, Huazhong Zhou, Li Zhang, Xiaoqiong Gu
A previous family-based linkage study revealed that Kawasaki disease (KD) was associated with variations of the ATP-binding cassette subfamily C member 4 (ABCC4) gene in most European populations. However, significant differences exist among ethnic populations in European and Chinese subjects; therefore, whether ABCC4 variants indicate susceptibility to KD in Chinese children is unclear. The purpose of this research was to evaluate correlations between ABCC4 gene polymorphisms and susceptibility to KD in a Southern Chinese population...
2018: Disease Markers
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