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Disease Markers

J Banach, Ł Wołowiec, D Rogowicz, L Gackowska, I Kubiszewska, W Gilewski, J Michałkiewicz, W Sinkiewicz
Introduction: Procalcitonin (PCT) is an excellent marker of sepsis but was not extensively studied in cardiology. The present study investigated PCT plasma concentration in patients with chronic heart failure with reduced ejection fraction (HFrEF) and its prognostic value during 24-month follow-up. Material and Methods: Study group consisted of 130 patients with HFrEF (LVEF ≤ 45%) and 32 controls. PCT level was assessed on admission in all patients. Telephone follow-up was performed every three months over a period of 2 years...
2018: Disease Markers
Xuemei Liu, Xianglan Jin, Baoxin Chen, Xiaohan Liu, Xiao Liang, Xiaolei Fang, Hongyun Wu, Xiaoyu Fu, Hong Zheng, Xiao Ding, Na Duan, Yunling Zhang
Background: Kudiezi injection is a traditional Chinese medicine for acute cerebral infarction, but the exact mechanisms are poorly understood. Objective: To investigate the mechanisms of Kudiezi injection on the inflammatory response in the treatment of acute cerebral infarction. Methods: This was a prospective study of patients with acute cerebral infarction within 48 h of onset and treated between July 2012 and July 2016 at three hospitals in China...
2018: Disease Markers
Sonia Mirabet, Alvaro García-Osuna, Pablo Garcia de Frutos, Andreu Ferrero-Gregori, Vicens Brossa, Laura Lopez, Ruben Leta, Joan Garcia-Picart, Josep M Padro, José Luis Sánchez-Quesada, Juan Cinca, Jordi Ordonez-Llanos, Eulalia Roig
Antecedents: Cardiac allograft vasculopathy (CAV) is a frequent complication limiting the long-term (>1 year) survival after heart transplantation (HTx). CAV is initiated by endothelial dysfunction and can lead to severe cardiovascular (CV) complications. Since CAV is often clinically silent, biomarkers could help identifying HTx patients at risk of CAV and their severe complications. Aim: Evaluate the clinical yield of high-sensitivity cardiac troponin T (hs-cTnT), marker of cardiomyocyte damage, and the soluble form of AXL (sAXL), biomarker of endothelial dysfunction, to assess the prognosis of long-term cardiovascular (CV) events occurring after HTx...
2018: Disease Markers
Tielong Tang, Chao Yang, Ham Ebo Brown, Jing Huang
Heat shock protein 70 (HSP70) was a highly conserved protein which was significantly induced in response to cellular stresses. HSP70 played an important role in the pathogenesis of cancer which stabilized the production of large amount of oncogenic proteins and finally supported growth and survival of tumor. However, there was no report about the diagnosis of circulating HSP70 in lung cancer patients. In this study, a total of 297 participants (lung cancer: 197, healthy control: 100) were enrolled in the detection of circulating HSP70 level in plasma by ELISA assay...
2018: Disease Markers
Ping Wang, Yanfeng Zhu, Shoumin Xi, Sanqiang Li, Yanle Zhang
Manganese superoxide dismutase (MnSOD) plays a critical role in the defense against reactive oxygen species. The association between MnSOD Val16Ala polymorphism and cancer risk has been widely studied, but the results are contradictory. To obtain more precision on the association, we performed the current meta-analysis with 33,098 cases and 37,831 controls from 88 studies retrieved from PubMed, Embase, Chinese National Knowledge Infrastructure (CNKI), and Wanfang databases. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of association...
2018: Disease Markers
Yuli Huang, Jianjin Luo, Xinyue Liu, Yu Wu, You Yang, Wensheng Li, Weibiao Lv, Yunzhao Hu
Background: Serum gamma-glutamyltransferase (GGT) is a biomarker of hepatic disease. Recent studies have shown that GGT may also associate with the risk of coronary artery disease. However, the underlying mechanisms of this association are still unclear. Methods: This study included 216 young patients with acute coronary syndrome (aged ≤55years) and 227 age-matched controls with normal findings by coronary angiography or coronary computed tomography angiography...
2018: Disease Markers
Alexander Koch, Ralf Weiskirchen, Alexander Krusch, Jan Bruensing, Lukas Buendgens, Ulf Herbers, Eray Yagmur, Ger H Koek, Christian Trautwein, Frank Tacke
The adipokine visfatin, also termed pre-B-cell colony-enhancing factor (PBEF), is mainly derived from adipose tissue but has been implicated in the regulation of innate immune responses. We hypothesized that visfatin could be a potential circulating biomarker in critical illness and sepsis. We therefore measured serum levels of visfatin in a cohort of 229 critically ill medical patients upon admission to the intensive care unit (ICU). In comparison to 53 healthy controls, visfatin levels were significantly elevated in medical ICU patients, especially in patients with sepsis...
2018: Disease Markers
Vadivel Masilamani, Sandanasamy Devanesan, Fatma AlQathani, Mashael AlShebly, Hebatullah Hassan Daban, Duran Canatan, Karim Farhat, Mansour Jabry, Mohamad S AlSalhi
Sickle cell anemia (SCA) is an inherited blood disorder with worldwide incidence of 15%; out of this, it is found in up to 20% in countries like Kingdom of Saudi Arabia and Bahrain. The standard conventional method of detection is complete blood count (CBC) followed by hemoglobin electrophoresis or high-performance liquid chromatography (HPLC) or both. In this context, spectral detection of variants of sickle cell anemia (SCA) is an innovative technique, which when made accurate and reliable could be an effective alternative, since the instrumentation is compact (5 kg) and hence portable...
2018: Disease Markers
Siyuan Tan, Ping Chen, Jiafu Ji, Shanshan Guo, Dapeng Yu, Tetsuya Asakawa, Yu Zhou, Masanobu Abe, Liang Zong
Objectives: Sunitinib (a second-line chemotherapeutic agent that inhibits multiple kinases, including KIT and PDGFR) is widely used in imatinib-resistant patients with gastrointestinal stromal tumors (GISTs). However, diverse responses to sunitinib have been observed in the clinic. We aimed to evaluate whether the different GIST genotypes could be used to stratify patient response to sunitinib. Methods: We searched the PubMed, Embase, and Cochrane databases and included English-language literature published up to August 31, 2017...
2018: Disease Markers
Radomír Hyšpler, Alena Tichá, Roman Šafránek, Petr Moučka, Zora Nývltová, Karolína Štochlová, Sylvie Dusilová-Sulková, Zdeněk Zadák
Indoxyl sulfate has been identified as a major factor in the dysregulation of several genes. It is classified as a poorly dialyzable uremic toxin and thus a leading cause in the poor survival rate of dialysis patients. A monocentric, prospective, open cohort study was performed in 43 male patients undergoing chronic renal replacement therapy in a single hemodialysis center. The aim of the study was to determine the influence of acetate- versus citrate-buffered dialysis fluids in hemodialysis (HD) and postdilution hemodiafiltration (HDF) settings on the elimination of indoxyl sulfate...
2018: Disease Markers
M Fryczkowski, R J Bułdak, T Hejmo, M Kukla, K Żwirska-Korczala
Background: Prostate cancer (PCa) is the first in terms of occurrence in Europe and second in Poland. The PCa risk factors include: genetic load, obesity, diet rich in fat, hypertriglyceridemia, and exposure to androgens. The prostate-specific antigen (PSA) level may be elevated in prostate cancer or other prostate disorders. Fat tissue secretes adipocytokines, which increase the risk of cancer development and metastasis. Objectives: The aims of the study were to investigate the relationship between circulating levels of PSA, adipocytokines: omentin, leptin, hepatocyte growth factor (HGF), and vascular endothelial growth factor (VEGF) in serum obtained from patients with benign prostate hyperplasia (BPH) and prostate cancer (PCa)...
2018: Disease Markers
Fabián Aldunate, Natalia Echeverría, Daniela Chiodi, Pablo López, Adriana Sánchez-Cicerón, Alvaro Fajardo, Martín Soñora, Juan Cristina, Nelia Hernández, Pilar Moreno
Hepatitis C Virus (HCV) infection treatment has dramatically changed with the advent of direct-acting antiviral agents (DAAs). However, the efficacy of DAAs can be attenuated by the presence of resistance-associated substitutions (RASs) before and after treatment. Indeed, RASs detected in DAA treatment-naïve HCV-infected patients could be useful for clinical management and outcome prediction. Although the frequency of naturally occurring HCV NS5A and NS5B RASs has been addressed in many countries, there are only a few reports on their prevalence in the South American region...
2018: Disease Markers
Yoshimi Kishimoto, Susumu Ibe, Emi Saita, Kenji Sasaki, Hanako Niki, Kotaro Miura, Yukinori Ikegami, Reiko Ohmori, Kazuo Kondo, Yukihiko Momiyama
Aims: Heme oxygenase-1 (HO-1) is an intracellular enzyme that catalyzes the oxidation of heme to generate CO, biliverdin, and iron. Since these products have antiatherogenic properties, HO-1 may play a protective role against the progression of atherosclerosis. However, plasma HO-1 levels in patients with atherosclerotic diseases, such as coronary artery disease (CAD) and peripheral artery disease (PAD), have not been clarified yet. Methods: We investigated plasma HO-1 levels by ELISA in 410 consecutive patients undergoing elective coronary angiography who also had an ankle-brachial index (ABI) test for PAD screening...
2018: Disease Markers
Shuang-Lei Wang, Rui Zhang, Kong-Zu Hu, Mao-Qiang Li, Zhan-Chun Li
Background: Inflammation might play a crucial role in the pathogenesis of osteoarthritis (OA). Interleukin-34 (IL-34) is a well-known proinflammatory cytokine. Objective: The objective of this study was to detect IL-34 levels in serum and synovial fluid (SF) of patients with OA and to investigate their correlation with radiographic and symptomatic severity. Methods: One hundred and eighty-two OA patients and 69 controls were recruited. IL-34 levels were measured by enzyme-linked immunosorbent assay (ELISA)...
2018: Disease Markers
Zengxiang Dong, Zhaoguang Liang, Meihua Guo, Shuang Hu, Zhaoqian Shen, Xin Hai
Aim: Trimethylamine N-oxide (TMAO) has been demonstrated as an independent risk factor for cardiovascular disease. Our objective was to determine the plasma levels of TMAO in Chinese coronary heart disease (CHD) patients with or without type 2 diabetes mellitus (T2DM). Methods: A total of 132 control participants, 243 CHD patients, and 175 CHD patients with T2DM were enrolled. Plasma levels of TMAO in all patients were measured and analyzed. Results: The plasma levels of TMAO were significantly higher in CHD patients than in control subjects (3...
2018: Disease Markers
Rodrigo Mota de Oliveira, Camylla Vilas Boas Figueiredo, Rayra Pereira Santiago, Sètondji Cocou Modeste Alexandre Yahouédéhou, Suéllen Pinheiro Carvalho, Silvana Souza da Paz, Luciana Magalhães Fiuza, Fernando Nunes de Miranda, Caroline Conceição da Guarda, Cleverson Alves Fonseca, Milena Magalhães Aleluia, Cynara Gomes Barbosa, Elisângela Vitória Adorno, Marilda de Souza Gonçalves
Background: The nonracial leukopenia may be a result of exposure to polycyclic derivatives (benzene-toluene-xylene (BTX)) and may arise from a possible change in the bone marrow microenvironment. The present study sought to evaluate the association of genetic polymorphisms in xenobiotic-metabolizing enzymes with hematological and biochemical profiles. Methods: We evaluated 89 African descendant children, exposed indirectly to benzene derivatives. Laboratory parameters were investigated by automated methods and genetic polymorphisms by PCR-RFLP and PCR multiplex...
2018: Disease Markers
Liang Liu, Jianjiao Ni, Xinhong He
Lung cancer is the leading cause of cancer-associated mortalities worldwide. Non-small-cell lung cancer (NSCLC) is the main reason for cancer-relevant death and constitutes 80% of lung cancer cases. Long noncoding RNAs (lncRNAs) have been found to be related to different kinds of cancer. Long noncoding RNAs played important roles in regulating the pathological and physiological processes of numerous cancers. To explore novel lung adenocarcinoma-associated lncRNAs, we analyzed the TCGA database and found that the lncRNA SNHG3 was significantly upregulated in lung adenocarcinoma...
2018: Disease Markers
Lesley Maurice Bilung, Chai Fung Pui, Lela Su'ut, Kasing Apun
In the last decades, leptospirosis had gained public health concern due to morbidity and mortality rates caused by pathogenic Leptospira . The need for rapid and robust molecular typing methods to differentiate this zoonotic pathogen is of utmost importance. Various studies had been conducted to determine the genetic relatedness of Leptospira isolates using molecular typing methods. In this study, 29 pathogenic Leptospira isolates from rat, soil, and water samples in Sarawak, Malaysia, were characterized using BOX-PCR and ERIC-PCR...
2018: Disease Markers
Saeed Alassiri, Pirjo Parnanen, Nilminie Rathnayake, Gunnar Johannsen, Anna-Maria Heikkinen, Richard Lazzara, Peter van der Schoor, Jan Gerrit van der Schoor, Taina Tervahartiala, Dirk Gieselmann, Timo Sorsa
The analysis of the disease-specific oral and systemic biomarkers in saliva and oral fluids (i.e., mouth rinse, gingival crevicular fluid (GCF), and peri-implantitis fluid (PISF)) is demanding. Several hosts and microbial factors may influence their expression, release, and levels. The type of saliva/oral fluids utilized for the diagnostics affects the analysis. High sensitivity and specificities together with sophisticated methods and techniques are essential for valuable outcome. We describe here recently developed practical, convenient, inexpensive, noninvasive, and quantitative mouth rinse and PISF/GCF/chair-side/point-of-care (PoC) lateral-flow aMMP-8 immunoassays (PerioSafe and ImplantSafe/ORALyser) to detect, predict, and monitor successfully the course, treatment, and prevention of periodontitis and peri-implantitis, respectively...
2018: Disease Markers
Luisana Brito-Mendoza, Ronell Bologna-Molina, María Esther Irigoyen-Camacho, Guillermo Martinez, Celeste Sánchez-Romero, Adalberto Mosqueda-Taylor
Background and Objective: Reduced expression of syndecan-1 (CD138), increased proliferation index, and modifications in the expression of the molecular RANK/RANKL/OPG triad are related to an intensified potential of aggressiveness and invasion of diverse tumors and cysts. The aim was to compare the expression of Ki-67, CD138, and the molecular triad RANK, RANKL, and OPG in odontogenic keratocysts (OKC), unicystic ameloblastomas (UA), and dentigerous cysts (DC). Methods: Immunohistochemistry for Ki-67, CD138, RANK, RANKL, and OPG was performed in 58 odontogenic cystic lesions (22 OKC, 17 DC, and 19 UA)...
2018: Disease Markers
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