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Disease Markers

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https://www.readbyqxmd.com/read/29332987/elevated-serum-mir-7-mir-9-mir-122-and-mir-141-are-noninvasive-biomarkers-of-acute-pancreatitis
#1
Pan Lu, Feng Wang, Jia Wu, Cheng Wang, Jing Yan, Zhuo-Ling Li, Jia-Xi Song, Jun-Jun Wang
Background: It has been reported that several microRNAs (miRNAs), such as miR-141, miR-9, and miR-122, are involved in the regulation of pancreatitis-related proteins or that their levels change in acute pancreatitis (AP) animal models. However, the serum levels, as well as the clinical diagnostic and prognostic values, of these miRNAs in AP patients remain unclear. Furthermore, as a pancreas- (islet) enriched miRNA, miR-7 was reported to be downregulated in AP patients, which requires further verification...
2017: Disease Markers
https://www.readbyqxmd.com/read/29317791/purple-urine-bag-syndrome-a-rare-spot-diagnosis
#2
REVIEW
Dilraj S Kalsi, Joel Ward, Regent Lee, Ashok Handa
Purple urine bag syndrome (PUBS) is a complication of urinary tract infections (UTIs) where catheter bags and tubing turn purple. It is alarming for patients, families, and clinicians; however, it is in itself a benign phenomenon. PUBS is the result of UTIs with specific bacteria that produce sulphatases and phosphatases which lead tryptophan metabolism to produce indigo (blue) and indirubin (red) pigments, a mixture of which becomes purple. Risk factors include female gender, immobility, constipation, chronic catheterisation, and renal disease...
2017: Disease Markers
https://www.readbyqxmd.com/read/29317790/role-of-mmp-1-519a-g-1607-1g-2g-mmp-3-lys45glu-mmp-7-181a-g-and-mmp-12-82a-g-variants-and-plasma-mmp-levels-on-obesity-related-phenotypes-and-microvascular-reactivity-in-a-tunisian-population
#3
Soumaya Boumiza, Sarra Bchir, Hela Ben Nasr, Ammar Abbassi, Marie-Paule Jacob, Xavier Norel, Zouhair Tabka, Karim Chahed
Aims: The impact of MMP-1 (-519A/G, -1607 1G/2G), MMP-3 Lys45Glu (A/G), MMP-7 -181A/G, and MMP-12 -82A/G variants and plasma MMP levels on obesity and microvascular reactivity in Tunisians. Methods: Our population included 202 nonobese and 168 obese subjects. Anthropometric, biochemical, and microvascular parameters were determined according to standard protocols. PCR-RFLP and ELISA were used to determine the genetic variants and levels of MMPs, respectively. Results: The MMP-3 45Glu (G) allele associates with higher anthropometric values and MMP-3 levels compared to AA genotype carriers (BMI (kg/m2): 30 ± 0...
2017: Disease Markers
https://www.readbyqxmd.com/read/29311755/expression-of-adipor1-and-adipor2-receptors-as-leptin-breast-cancer-regulation-mechanisms
#4
Martha Daniela Mociño-Rodríguez, Jonnathan Guadalupe Santillán-Benítez, David Salomón Dozal-Domínguez, María Dolores Hernández-Navarro, Miriam Veronica Flores-Merino, Antonio Sandoval-Cabrera, Francisco Javier García Vázquez
The development of breast cancer is influenced by the adipose tissue through the proteins leptin and adiponectin. However, there is little research concerning AdipoR1 and AdipoR2 receptors and the influence of leptin over them. The objective of this work was to analyze the expression of AdipoR1 and AdipoR2, modulated by differential concentrations of leptin in an obesity model (10 ng/mL, 100 ng/mL, and 1000 ng/mL) associated with breast cancer in MCF-7 and HCC1937 cell lines. Each cell line was characterized through immunohistochemistry, and the expression of AdipoR1 and AdipoR2 was analyzed by PCR in real time using TaqMan® probes...
2017: Disease Markers
https://www.readbyqxmd.com/read/29269980/within-subject-reliability-and-between-subject-variability-of-oxidative-stress-markers-in-saliva-of-healthy-subjects-a-longitudinal-pilot-study
#5
Iva Z Alajbeg, Ivana Lapić, Dunja Rogić, Lea Vuletić, Ana Andabak Rogulj, Davor Illeš, Dubravka Knezović Zlatarić, Tomislav Badel, Ema Vrbanović, Ivan Alajbeg
The present study evaluated diurnal variations and day-to-day fluctuations of salivary oxidative stress (OS) markers in healthy adult individuals. Whole unstimulated saliva was collected at 2 time intervals over 3 consecutive days. Glutathione peroxidase (GPX), superoxide dismutase (SOD), total antioxidant capacity (TAC), and uric acid (UA) were analyzed using spectrophotometric methods, while 8-hydroxydeoxyguanosine (8-OHdG) and malondialdehyde (MDA) were determined using immunoassays. No significant differences for salivary OS markers between men and women were observed...
2017: Disease Markers
https://www.readbyqxmd.com/read/29259350/decreased-helios-expression-in-regulatory-t-cells-in-acute-coronary-syndrome
#6
Lili Jiang, Feng Chen, Xiaofan Hu, Yingying Hu, Yange Wang, Wenyong Zhang, Yudong Peng, Longxian Cheng
Regulatory T cells (Tregs) play an essential role in acute coronary syndrome (ACS). However, there is debate about which Treg subsets are truly critical to ACS. Helios, a transcription factor, was recently reported to be a bona fide marker for natural Tregs or activated Tregs with a suppression function, but little is known about its role in ACS. We therefore examined Helios+ Tregs in patients with ACS, patients with stable angina, and control subjects. 73 patients with ACS, 30 patients with stable angina, and 48 control subjects were enrolled...
2017: Disease Markers
https://www.readbyqxmd.com/read/29259349/are-fusion-transcripts-in-relapsed-metastatic-head-and-neck-cancer-patients-predictive-of-response-to-anti-egfr-therapies
#7
Paolo Bossi, Marco Siano, Cristiana Bergamini, Maria Cossu Rocca, Andrea P Sponghini, Marco Giannoccaro, Luca Tonella, Alessandro Paoli, Edoardo Marchesi, Federica Perrone, Silvana Pilotti, Laura D Locati, Silvana Canevari, Lisa Licitra, Loris De Cecco
Prediction of benefit from combined chemotherapy and the antiepidermal growth factor receptor cetuximab is a not yet solved question in head and neck squamous cell carcinoma (HNSCC). In a selected series of 14 long progression-free survival (PFS) and 26 short PFS patients by whole gene and microRNA expression analysis, we developed a model potentially predictive of cetuximab sensitivity. To better decipher the "omics" profile of our patients, we detected transcript fusions by RNA-seq through a Pan-Cancer panel targeting 1385 cancer genes...
2017: Disease Markers
https://www.readbyqxmd.com/read/29238120/biomarkers-of-cardiovascular-disease
#8
EDITORIAL
Ying Huang, Kailash Gulshan, Truc Nguyen, Yuping Wu
No abstract text is available yet for this article.
2017: Disease Markers
https://www.readbyqxmd.com/read/29209100/corrigendum-to-rantes-gene-polymorphisms-associated-with-hiv-1-infections-in-kenyan-population
#9
Shem P M Mutuiri, Helen L Kutima, Lamech M Mwapagha, James K Munyao, Anthony Nyamache Kebira, Irene Wanjiru, Samoel A Khamadi
[This corrects the article DOI: 10.1155/2016/4703854.].
2017: Disease Markers
https://www.readbyqxmd.com/read/29209099/polymorphisms-in-ccr5%C3%AE-32-and-risk-of-hiv-1-infection-in-the-southeast-of-caspian-sea-iran
#10
Zahra Heydarifard, Alijan Tabarraei, Abdolvahab Moradi
Prevalence of CCR5Δ32 among blood samples of more than 400 healthy and HIV-1-infected people was investigated in Iran. Polymerase chain reaction (PCR) following DNA extraction was used. Desired frequency was analyzed by Hardy-Weinberg equilibrium (HWE) analysis and SPSS 16.0 software to harvest the results. The prevalence of CCRΔ32 heterozygote genotype was 3% in healthy people and 0.7% in HIV-1-infected individuals. There was no homozygote CCR5Δ32 in both groups, and the allele Δ32 was only observed in 1...
2017: Disease Markers
https://www.readbyqxmd.com/read/29209098/the-distribution-frequency-of-interferon-gamma-receptor-1-gene-polymorphisms-in-interferon-%C3%AE-release-assay-positive-patients
#11
Changguo Chen, Lei Chen, Changwei Chen, Qiuyuan Chen, Qiangyuan Zhao, Youyou Dong
Tuberculosis is caused by mycobacterium, a potentially fatal infectious bacterium. In recent years, TB cases increased in the whole world. WHO statistics data shows that the world's annual tuberculosis incidence was 8~10 million with about 3 million deaths. Several studies have shown that susceptibility to tuberculosis may be associated with IFNGR1 gene polymorphisms. Here, we report the distribution frequency of IFNGR1 gene polymorphisms in 103 cases of IGA-negative patients and 100 cases of IGA-positive patients from China by sequencing the IFNGR1 proximal ~750 bp promoter region...
2017: Disease Markers
https://www.readbyqxmd.com/read/29200599/expression-levels-and-localizations-of-dvl3-and-sfrp3-in-glioblastoma
#12
Anja Kafka, Davor Tomas, Mirna Lechpammer, Tea Gabud, Leo Pažanin, Nives Pećina-Šlaus
The expression patterns of critical molecular components of Wnt signaling, sFRP3 and DVL3, were investigated in glioblastoma, the most aggressive form of primary brain tumors, with the aim to offer potential biomarkers. The protein expression levels and localizations in tumor tissue were revealed by immunohistochemistry and evaluated by the semiquantitative method and immunoreactivity score. Majority of glioblastomas had moderate expression levels for both DVL3 (52.4%) and sFRP3 (52.3%). Strong expression levels were observed in 23...
2017: Disease Markers
https://www.readbyqxmd.com/read/29200598/vitamin-d-status-disease-activity-and-endothelial-dysfunction-in-early-rheumatoid-arthritis-patients
#13
Alexandru Caraba, Viorica Crişan, Ioan Romoşan, Ioana Mozoş, Marius Murariu
Cardiovascular diseases represent important complications in rheumatoid arthritis (RA) patients, generated by an accelerated atherosclerosis. The aim of this study is represented by the assessment of the correlations between serum levels of vitamin D, disease activity, and endothelial dysfunction in patients with early RA. Material and Methods. The study was performed on a group of 35 patients with early RA and 35 healthy subjects matched for age and gender, as controls. In all studied subjects, the following were determined: inflammatory markers, insulin resistance, vitamin D levels, and endothelial dysfunction...
2017: Disease Markers
https://www.readbyqxmd.com/read/29200597/plasma-fibulin-3-as-a-potential-biomarker-for-patients-with-asbestos-related-diseases-in-the-han-population
#14
Zhaoqiang Jiang, Shibo Ying, Wei Shen, Xianglei He, Junqiang Chen, Hailing Xia, Min Yu, Yun Xiao, Lingfang Feng, Lijin Zhu, Li Ju, Xinnian Guo, Yixiao Zhang, Jia-Wei Shen, Yan Tong, Xing Zhang, Jianlin Lou
Fibulin-3 has been reported as a potential biomarker for mesothelioma. However, little is known about the diagnostic efficacies of fibulin-3 for asbestos-related diseases (ARDs) in China. This study was to investigate the utility of fibulin-3 for asbestos exposure and ARDs. A total of 430 subjects were recruited from Southeast China, including healthy individuals, asbestos-exposed (AE) individuals, and patients with pleural plaques (PP), asbestosis, and malignant pleural mesothelioma (MPM). Plasma fibulin-3 was measured using the enzyme-linked immunosorbent assay...
2017: Disease Markers
https://www.readbyqxmd.com/read/29180834/increased-levels-of-s100a8-a9-in-patients-with-peritonsillar-abscess-a-new-promising-diagnostic-marker-to-differentiate-between-peritonsillar-abscess-and-peritonsillitis
#15
Christoph Spiekermann, Antonella Russo, Markus Stenner, Claudia Rudack, Johannes Roth, Thomas Vogl
Peritonsillar abscess (PTA) is a very frequent reason for urgent outpatient consultation and otolaryngological hospital admission. Early, correct diagnosis and therapy of peritonsillar abscess are important to prevent possible life-threatening complications. Based on physical examinations, a reliable differentiation between peritonsillar cellulitis and peritonsillar abscess is restricted. A heterodimeric complex called calprotectin consists of the S100 proteins A8 and A9 (S100A8/A9) and is predominantly expressed not only in monocytes and neutrophils but also in epithelial cells...
2017: Disease Markers
https://www.readbyqxmd.com/read/29180833/growth-differentiation-factor-15-is-a-predictor-of-mortality-in-critically-ill-patients-with-sepsis
#16
Lukas Buendgens, Eray Yagmur, Jan Bruensing, Ulf Herbers, Christer Baeck, Christian Trautwein, Alexander Koch, Frank Tacke
Growth differentiation factor-15 (GDF-15) is a member of the transforming growth factor-β superfamily related to inflammation and macrophage activation. Serum concentrations of GDF-15 can predict poor survival in chronic diseases, but its role in sepsis is obscure. Therefore, we investigated GDF-15 as a prognostic biomarker in critically ill patients. We measured GDF-15 levels in 219 critically ill patients (146 with sepsis, 73 without sepsis) upon admission to the intensive care unit (ICU), in comparison to 66 healthy controls...
2017: Disease Markers
https://www.readbyqxmd.com/read/29162948/association-between-recipient-il-15-genetic-variant-and-the-prognosis-of-hbv-related-hepatocellular-carcinoma-after-liver-transplantation
#17
Tao Zhang, Yuan Liu, Xu Peng, Junwei Fan, Zhihai Peng
Objective: To investigate the association of donor and recipient IL-15 genetic variants with HCC recurrence and prognosis after LT. Methods: A total of 112 liver transplant patients with HBV-related HCC were enrolled. IL-15 rs10519613 and rs13122930 were genotyped in donors and recipients. Results: Recipient IL-15 rs10519613 polymorphism was found to be significantly related to HCC recurrence after LT. In multivariate analysis, tumor thrombus, UCSF criteria, and recipient IL-15 rs10519613 genotypes were independent predictive factors of HCC recurrence after LT...
2017: Disease Markers
https://www.readbyqxmd.com/read/29158612/detection-of-pathological-changes-in-the-aorta-during-thoracic-aortic-aneurysm-progression-on-molecular-level
#18
Miroslava Rabajdová, Peter Urban, Ivana Špaková, Artemiou Panagiotis, Michaela Ferenčáková, Dušan Rybár, Nikita Bobrov, František Sabol, Mária Mareková
The progression of thoracic aortic aneurysm depends on regulation of aortic wall homeostasis and on changes in the structural components of the extracellular matrix, which are affected by multiple molecular signalling pathways. We decided to correlate the diameter of ascending thoracic aneurysm with gene expression of inflammation markers (IL-6, CRP), cytokine receptors (IL-6R, TNFR1, and TNFR2), and extracellular matrix components (Emilin-1, MMP9, and TIMP) for detection of the degree of pathological process of TAA formation...
2017: Disease Markers
https://www.readbyqxmd.com/read/29147064/lncrna-neat1-regulates-cell-viability-and-invasion-in-esophageal-squamous-cell-carcinoma-through-the-mir-129-ctbp2-axis
#19
Yong Li, Dong Chen, Xiang Gao, Xiaohui Li, Gongning Shi
Background: Long noncoding RNA nuclear paraspeckle assembly transcript 1 (NEAT1) was reported to be aberrantly upregulated and promote esophageal squamous cell carcinoma (ESCC) cell progression. Nevertheless, the molecular mechanism of NEAT1 involved in the competing endogenous RNA (ceRNA) regulatory network in ESCC progression remains poorly defined. Methods: The expressions of NEAT1, miR-129, and C-terminal-binding protein 2 (CTBP2) in ESCC cells were examined by qRT-PCR...
2017: Disease Markers
https://www.readbyqxmd.com/read/29138529/matrix-metalloproteinases-polymorphisms-as-prognostic-biomarkers-in-malignant-pleural-mesothelioma
#20
Danijela Štrbac, Katja Goričar, Vita Dolžan, Viljem Kovač
Background: Malignant pleural mesothelioma (MPM) is a rare disease with a relatively short overall survival (OS). Metalloproteinases (MMPs) have a vast biological effect on tumor progression, invasion, metastasis formation, and apoptosis. MMP expression was previously associated with survival in MPM. Our aim was to evaluate if genetic variability of MMP genes could also serve as a prognostic biomarker in MPM. Methods: We genotyped 199 MPM patients for ten polymorphisms: rs243865, rs243849 and rs7201, in MMP2; rs17576, rs17577, rs20544, and rs2250889 in MMP9; and rs1042703, rs1042704, and rs743257 in MMP14...
2017: Disease Markers
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