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Disease Markers

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https://www.readbyqxmd.com/read/28713192/foxp3-allelic-variants-and-haplotype-structures-are-associated-with-aggressive-breast-cancer-subtypes
#1
Bruna Karina Banin Hirata, Roberta Losi Guembarovski, Glauco Akelinghton Freire Vitiello, Alda Losi Guembarovski, Karen Brajão de Oliveira, Maria Angelica Ehara Watanabe
FOXP3 genetic polymorphisms have been associated with cancer development and prognosis. In this context, the present study aimed to evaluate the g.10403A>G (rs2232365) polymorphisms and g.8048A>C (rs3761548), in aggressive breast cancer (BC) subtypes, including, Luminal B HER2+ (LB), HER2-enriched (HER2+), and triple-negative (TN). Polymerase chain reaction followed by enzymatic restriction was performed to genotyping 117 BC samples and 300 controls. A significant association of AA genotype (g.10403A>G) in relation to BC susceptibility (OR = 1...
2017: Disease Markers
https://www.readbyqxmd.com/read/28701807/natriuretic-peptides-as-biomarkers-for-congestive-states-the-cardiorenal-divergence
#2
REVIEW
Abhilash Koratala, Amir Kazory
Congestion represents the primary reason for hospitalization of patients with heart failure and is associated with adverse outcomes. Fluid overload has been shown to be inadequately addressed in a significant subset of these patients in part due to lack of robust, reliable, and readily available biomarkers for objective assessment and monitoring of therapy. Natriuretic peptides have long been used in this setting, often in conjunction with other assessment tools such as imaging studies. Patients presenting with concomitant cardiac and renal dysfunction represent a unique population with regard to congestion in that the interactions between the heart and the kidney can affect the utility and performance of biomarkers of fluid overload...
2017: Disease Markers
https://www.readbyqxmd.com/read/28694560/peritransplant-soluble-cd30-as-a-risk-factor-for-slow-kidney-allograft-function-early-acute-rejection-worse-long-term-allograft-function-and-patients-survival
#3
Andriy V Trailin, Tetyana I Ostapenko, Tamara N Nykonenko, Svitlana N Nesterenko, Olexandr S Nykonenko
BACKGROUND: We aimed to determine whether serum soluble CD30 (sCD30) could identify recipients at high risk for unfavorable early and late kidney transplant outcomes. METHODS: Serum sCD30 was measured on the day of kidney transplantation and on the 4th day posttransplant. We assessed the value of these measurements in predicting delayed graft function, slow graft function (SGF), acute rejection (AR), pyelonephritis, decline of allograft function after 6 months, and graft and patient survival during 5 years of follow-up in 45 recipients...
2017: Disease Markers
https://www.readbyqxmd.com/read/28694559/association-of-single-nucleotide-polymorphisms-in-dc-sign-with-nasopharyngeal-carcinoma-susceptibility
#4
Sisi Li, Zhifang Lu, Mengwei Yao, Sisi Ning, Yuan Wu, Xunzhao Zhou, Changtao Zhong, Kui Yan, Ying Xie, Zhengbo Wei
The aim of this study was to explore potential relationships of four single-nucleotide polymorphisms (SNPs) in the gene encoding dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN) with risk of nasopharyngeal carcinoma (NPC). The DC-SIGN SNPs rs7252229, rs4804803, rs2287886, and rs735240 were genotyped in 477 unrelated NPC patients and 561 cancer-free controls. At rs7252229, risk of NPC was significantly lower in individuals with GC (odds ratio [OR] 0.076, 95% confidence interval [CI] 0...
2017: Disease Markers
https://www.readbyqxmd.com/read/28694558/impact-of-vaccination-on-distribution-of-t-cell-subsets-in-antiretroviral-treated-hiv-infected-children
#5
Premrutai Thitilertdecha, Ladawan Khowawisetsut, Palanee Ammaranond, Poonsin Poungpairoj, Varangkana Tantithavorn, Nattawat Onlamoon
Antiretroviral therapy (ART) is generally prescribed to patients with human immunodeficiency virus (HIV) infection with vaccination introduced to prevent disease complications. However, little is known about the influence of immunization on T cell subsets' distribution during the course of infection. This study aims to identify the impact of viral replication and immunization on naïve, effector, effector memory, and central memory T cell subpopulations in ART-treated HIV-infected children. Fifty patients were recruited and injected intramuscularly with influenza A (H1N1) 2009 vaccine on the day of enrollment (day 0) and day 28...
2017: Disease Markers
https://www.readbyqxmd.com/read/28694557/overexpression-of-mir-24-is-involved-in-the-formation-of-hypocoagulation-state-after-severe-trauma-by-inhibiting-the-synthesis-of-coagulation-factor-x
#6
Lu-Jia Chen, Lian Yang, Xing Cheng, Yin-Kai Xue, Li-Bo Chen
BACKGROUND: Dysregulation of microRNAs may contribute to the progression of trauma-induced coagulopathy (TIC). We aimed to explore the biological function that miRNA-24-3p (miR-24) might have in coagulation factor deficiency after major trauma and TIC. METHODS: 15 healthy volunteers and 36 severe trauma patients (Injury Severity Score ≥ 16 were enrolled. TIC was determined as the initial international normalized ratio >1.5. The miR-24 expression and concentrations of factor X (FX) and factor XII in plasma were measured...
2017: Disease Markers
https://www.readbyqxmd.com/read/28684886/eg5-overexpression-is-predictive-of-poor-prognosis-in-hepatocellular-carcinoma-patients
#7
Can Liu, Nan Zhou, Jieying Li, Jun Kong, Xi Guan, Xudong Wang
Eg5 (kinesin spindle protein) plays an essential role in mitosis. Inhibition of Eg5 function results in cell cycle arrest at mitosis, which leads to cell death. To date, Eg5 expression and its prognostic significance have not been studied in hepatocellular carcinoma (HCC). In this study, 26 freshly frozen HCC tissue samples and matched peritumoral tissue samples were evaluated with a one-step qPCR test and immunohistochemical (IHC) analysis was conducted on 156 HCC samples to investigate the relationships among Eg5 expression, clinicopathological factors, and prognosis...
2017: Disease Markers
https://www.readbyqxmd.com/read/28676731/the-ratio-of-c-reactive-protein-albumin-is-a-novel-inflammatory-predictor-of-overall-survival-in-cisplatin-based-treated-patients-with-metastatic-nasopharyngeal-carcinoma
#8
Peng Sun, Cui Chen, Yi Xia, Xiwen Bi, Panpan Liu, Fei Zhang, Hang Yang, Xin An, Wenqi Jiang, Fenghua Wang
The C-reactive protein/albumin (CRP/Alb) ratio has been recently identified as a prognostic factor in various cancers, whereas its role remains unclear in metastatic nasopharyngeal carcinoma (NPC). The current study retrospectively analyzed 148 patients with metastatic NPC who underwent cisplatin-based chemotherapy and further evaluated the prognostic value of the CRP/Alb ratio and its association with clinical characteristics in these patients. The optimal cut-off value was 0.189 for the CRP/Alb ratio. The high CRP/Alb ratio was significantly associated with elevated NLR, platelet-to-lymphocyte ratio (PLR), and EBV-DNA levels and decreased haemoglobin level (all p < 0...
2017: Disease Markers
https://www.readbyqxmd.com/read/28659657/serum-gamma-glutamyl-transferase-and-ferritin-synergistically-associated-with-the-rate-of-chronic-kidney-disease
#9
Tao Chen, Yan Ren, Yun Gao, Haoming Tian
The present study investigated the effects of GGT and SF on the risk of CKD. 1024 participants (436 men and 588 women) were divided into three groups according to GGT and SF levels: group 1 (both GGT and SF not in the fourth quartile), group 2 (only GGT or SF in the fourth quartile), and group 3 (both GGT and SF in the fourth quartile). The risks of CKD in different levels of GGT and SF and in groups 2-3 compared with group 1 were analyzed by multiple logistic regression. GGT or SF in the highest quartile was associated with increased risk of CKD...
2017: Disease Markers
https://www.readbyqxmd.com/read/28659656/type-ii-endometrial-cancer-overexpresses-nilco-a-preliminary-evaluation
#10
Danielle Daley-Brown, Gabriela Oprea-Iles, Kiara T Vann, Viola Lanier, Regina Lee, Pierre V Candelaria, Alexander Quarshie, Roland Pattillo, Ruben Rene Gonzalez-Perez
OBJECTIVE: The expression of NILCO molecules (Notch, IL-1, and leptin crosstalk outcome) and the association with obesity were investigated in types I and II endometrial cancer (EmCa). Additionally, the involvement of NILCO in leptin-induced invasiveness of EmCa cells was investigated. METHODS: The expression of NILCO mRNAs and proteins were analyzed in EmCa from African-American (n = 29) and Chinese patients (tissue array, n = 120 cases). The role of NILCO in leptin-induced invasion of Ishikawa and An3ca EmCa cells was investigated using Notch, IL-1, and leptin signaling inhibitors...
2017: Disease Markers
https://www.readbyqxmd.com/read/28659655/expression-and-clinical-significance-of-cancer-stem-cell-markers-cd24-cd44-and-cd133-in-pancreatic-ductal-adenocarcinoma-and-chronic-pancreatitis
#11
L Durko, W Wlodarski, O Stasikowska-Kanicka, M Wagrowska-Danilewicz, M Danilewicz, P Hogendorf, J Strzelczyk, E Malecka-Panas
Cancer stem cells (CSC) play an important role in pancreatic carcinogenesis and prognosis. The study aimed at examining the expression of CD24, CD44, and CD133 in human PDAC and CP in order to evaluate its clinicopathological correlations and the clinical significance. Surgical specimens from 23 patients with PDAC and 15 patients with chronic pancreatitis after pancreatic resection were stained with CD24, CD44, and CD133 antibodies. The intensity of staining was scored from 0 (negative) to 3 (strongly positive)...
2017: Disease Markers
https://www.readbyqxmd.com/read/28655970/association-between-the-tacc3-rs798766-polymorphism-and-risk-of-urinary-bladder-cancer-a-synthesis-based-on-current-evidence
#12
REVIEW
Xiang-Yu Meng, Ming-Jun Shi, Jia-Feng Chen, Yi Liao, Bang-Wang Hu, Ahmed Hireche
BACKGROUND: A possible association between the TACC3 rs798766 polymorphism and urinary bladder cancer risk has been indicated in published literature. We performed this meta-analysis as a synthesis of all relevant data to summarize currently available evidence and to provide estimation with increased precision. METHODS: EMBASE, PubMed, Google Scholar, and Wanfang Data were searched. "rs798766" and "urinary bladder cancer" were used as the search terms. A total of 6 eligible studies were identified, in which 8194 cases and 50,165 controls were investigated...
2017: Disease Markers
https://www.readbyqxmd.com/read/28655969/the-immunosignature-of-mother-fetus-couples-in-gestational-diabetes-mellitus-role-of-hla-g-14%C3%A2-bp-ins-del-and-papp-a-a-c-polymorphisms-in-the-uterine-inflammatory-milieu
#13
Miryam Martinetti, Fausta Beneventi, Cristina Capittini, Elena Locatelli, Margherita Simonetta, Chiara Cavagnoli, Irene De Maggio, Annalisa De Silvestri, Annamaria Pasi, Arsenio Spinillo
We enrolled 151 healthy mother/newborn couples and 26 with gestational diabetes mellitus (GDM). HLA-G and PAPP-A plasma levels were measured by ELISA at first and second trimesters, at delivery, and in cord blood. HLA-G 14 bp ins/del and PAPP-A A/C polymorphisms were genotyped. HLA-G del/del and PAPP-A C/C genotypes were more frequent among GDM mothers than controls. We observed a genetic epistasis between the two polymorphisms: the HLA-G del/del and PAPP-A C/C combination was carried by 8% of GDM mothers and 1...
2017: Disease Markers
https://www.readbyqxmd.com/read/28634418/long-noncoding-rnas-as-biomarkers-in-cancer
#14
REVIEW
Luka Bolha, Metka Ravnik-Glavač, Damjan Glavač
Long noncoding RNAs (lncRNAs) are a relatively well-characterized class of noncoding RNA (ncRNA) molecules, involved in the regulation of various cell processes, including transcription, intracellular trafficking, and chromosome remodeling. Their deregulation has been associated with the development and progression of various cancer types, the fact which makes them suitable as biomarkers for cancer diagnosis and prognosis. In recent years, detection of cancer-associated lncRNAs in body fluids of cancer patients has proven itself as an especially valuable method to effectively diagnose cancer...
2017: Disease Markers
https://www.readbyqxmd.com/read/28634417/expression-status-of-piwil1-as-a-prognostic-marker-of-colorectal-cancer
#15
Rui Sun, Chun-Li Gao, Dong-Hai Li, Bo-Jun Li, Yan-Hong Ding
The PIWI-like protein 1 (PIWIL1) plays a crucial role in stem cell proliferation, embryogenesis, growth, and development, as well as differentiation and maturation in multiple organisms. The relationships between PIWIL1 expression and clinicopathological features of colorectal cancer (CRC) patients were analyzed by us. Survival analysis was performed using the Kaplan-Meier method and Cox's proportional hazards model. The high expression rate of PIWIL1 in the cancer tissue was obviously higher than that in the corresponding adjacent tissue...
2017: Disease Markers
https://www.readbyqxmd.com/read/28630527/a-promising-approach-to-integrally-evaluate-the-disease-outcome-of-cerebral-ischemic-rats-based-on-multiple-biomarker-crosstalk
#16
Guimei Ran, Yixuan Wang, Haochen Liu, Chunxiang Wei, Tao Zhu, Haidong Wang, Hua He, Xiaoquan Liu
PURPOSE: The study was designed to evaluate the disease outcome based on multiple biomarkers related to cerebral ischemia. METHODS: Rats were randomly divided into sham, permanent middle cerebral artery occlusion, and edaravone-treated groups. Cerebral ischemia was induced by permanent middle cerebral artery occlusion surgery in rats. To form a simplified crosstalk network, the related multiple biomarkers were chosen as S100β, HIF-1α, IL-1β, PGI2, TXA2, and GSH-Px...
2017: Disease Markers
https://www.readbyqxmd.com/read/28630526/discriminating-value-of-calprotectin-in-disease-activity-and-progression-of-nonradiographic-axial-spondyloarthritis-and-ankylosing-spondylitis
#17
Jinxian Huang, Zhihua Yin, Guoxiang Song, Shengjin Cui, Jinzhao Jiang, Lijun Zhang
It has been controversial whether ankylosing spondylitis (AS) and nonradiographic axial spondyloarthritis (nr-axSpA) are separate or different phases of radiographic progression. We determined that serum calprotectin level (ng/ml) was higher in AS (15.30 ± 6.49) and nr-axSpA (17.76 ± 8.59) patients than in healthy individuals (7.40 ± 2.67). No difference was observed in calprotectin level between these two groups. Elevated calprotectin was positively correlated with ESR, CRP, BASDAI, and ASDAS as well as SPARCC scoring and had no correlation with BASFI and mSASSS...
2017: Disease Markers
https://www.readbyqxmd.com/read/28626293/cd146-promoter-polymorphism-rs3923594-is-associated-with-recurrence-of-clear-cell-renal-cell-carcinoma-in-chinese-population
#18
Gang Feng, Hou-Bao Huang, Xiao-Bing Ye, Peng Zhang, Jian-Jun Huang, Li-Zhu Huang, Long Cheng, Chun Pu, Guorong Li
INTRODUCTION: CD146 is a membrane signal receptor in tumor-induced angiogenesis. However, limited studies have focused on the CD146 promoter polymorphisms in clear cell renal cell carcinoma (ccRCC). PURPOSE: The purpose of this study was to investigate the association between polymorphisms located in the promoter region of the CD146 gene and characteristics of ccRCC in Chinese population. The association between the CD146 promoter polymorphisms and CD146 expression was also investigated in ccRCC...
2017: Disease Markers
https://www.readbyqxmd.com/read/28607529/ev-associated-mmp9-in-high-grade-serous-ovarian-cancer-is-preferentially-localized-to-annexin-v-binding-evs
#19
Agnes T Reiner, Sisareuth Tan, Christiane Agreiter, Katharina Auer, Anna Bachmayr-Heyda, Stefanie Aust, Nina Pecha, Mattias Mandorfer, Dietmar Pils, Alain R Brisson, Robert Zeillinger, Sai Kiang Lim
High-grade serous ovarian cancer (HGSOC) is the most aggressive type of ovarian cancer and is responsible for most deaths caused by gynecological cancers. Numerous candidate biomarkers were identified for this disease in the last decades, but most were not sensitive or specific enough for clinical applications. Hence, new biomarkers for HGSOC are urgently required. This study aimed to identify new markers by isolating different extracellular vesicle (EV) types from the ascites of ovarian cancer patients according to their affinities for lipid-binding proteins and analyzing their protein cargo...
2017: Disease Markers
https://www.readbyqxmd.com/read/28607528/clinical-significance-and-prognostic-value-of-the-expression-of-lamp3-in-oral-squamous-cell-carcinoma
#20
Jun Lu, Hengcheng Ma, Shuijin Lian, Dan Huang, Min Lian, Ye Zhang, Jianfei Huang, Xingmei Feng
Recent studies demonstrated high expression of lysosome-associated membrane protein 3 (LAMP3) in a variety of malignancies including esophageal squamous cell carcinoma, gastrointestinal cancer, breast cancer, and cervical cancer and its involvement in several biological activities of tumor cells. However, the expression of LAMP3 and its value in oral squamous cell carcinoma (OSCC) remain unclear. In this study, we examined the expression of LAMP3 in OSCC tissue samples and investigated the relationship between LAMP3 and clinical characteristics of patients with OSCC...
2017: Disease Markers
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