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Disease Markers

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https://www.readbyqxmd.com/read/28811677/the-relationship-between-vegfa-and-tgfb1-polymorphisms-and-target-lesion-revascularization-after-elective-percutaneous-coronary-intervention
#1
Tadeusz Osadnik, Andrzej Lekston, Kamil Bujak, Joanna Katarzyna Strzelczyk, Lech Poloński, Mariusz Gąsior
BACKGROUND AND AIM: The specific association between genetic variation and in-stent restenosis is still only partly understood. The aim of this study is to analyze the relationship between functional polymorphisms in the genes encoding vascular endothelial growth factor A (VEGF-A; rs699947) and transforming growth factor beta 1 (TGF-β1; rs1800470) and target lesion revascularization (TLR) risk. METHODS: A total of 676 patients (805 lesions) with stable coronary artery disease (SCAD) who received elective percutaneous coronary intervention (PCI) with at least one bare-metal stent implantation were included...
2017: Disease Markers
https://www.readbyqxmd.com/read/28808355/new-markers-of-inflammation-and-tubular-damage-in-children-with-chronic-kidney-disease
#2
Kinga Musiał, Agnieszka Bargenda, Dorota Drożdż, Danuta Zwolińska
INTRODUCTION AND AIMS: Monocyte chemoattractant protein- (MCP-) 1, macrophage colony-stimulating factor (MCSF), and neopterin are connected with monocyte migration and transition into macrophages, leading to fibrosis and tubular damage in the course of CKD. The aim of the study was to analyze the applicability of urinary fractional excretion (FE) of MCP1, MCSF, and neopterin, as markers of inflammation and tubular damage, in children with CKD. METHODS: The study group consisted of 61 children with CKD stages 1-5 and 23 age-matched controls...
2017: Disease Markers
https://www.readbyqxmd.com/read/28790534/laboratory-and-genetic-biomarkers-associated-with-cerebral-blood-flow-velocity-in-hemoglobin-sc-disease
#3
Rayra Pereira Santiago, Camilo Vieira, Corynne Stephanie Ahouefa Adanho, Sanzio Silva Santana, Caroline Conceição Guarda, Camylla Vilas Boas Figueiredo, Luciana Magalhães Fiuza, Thassila Nogueira Pitanga, Junia Raquel Dutra Ferreira, Milena Magalhães Aleluia, Rodrigo Mota Oliveira, Dalila Luciola Zanette, Isa Menezes Lyra, Marilda Souza Goncalves
Reference values for cerebral blood flow velocity (CBFV) in hemoglobin SC disease (HbSC) have not been established. We aimed to investigate associations between laboratory and genetic biomarkers associated with CBFV in HbSC children. Sixty-eight HbSC children were included; CBFV was analyzed by transcranial Doppler, and the time-averaged maximum mean velocity (TAMMV) was estimated. Hematological, biochemical, immunological, and genetic analyses were performed. TAMMV was negatively correlated with red blood cell count (RBC) count, hemoglobin, hematocrit, and direct bilirubin (DB), yet positively correlated with monocytes and ferritin...
2017: Disease Markers
https://www.readbyqxmd.com/read/28790533/differential-expression-of-glycolysis-related-proteins-in-follicular-neoplasms-versus-h%C3%A3-rthle-cell-neoplasms-a-retrospective-analysis
#4
Hye Min Kim, Ja Seung Koo
PURPOSE: Although currently classified as variants of follicular neoplasms (FNs), Hürthle cell neoplasms (HCNs) exhibit distinct biological characteristics. Hence, the metabolism of both neoplasms may also be different. The aims of this study were to investigate and compare the expression of glycolysis-related proteins in HCNs and FNs and to determine the clinical implications of such expression. METHODS: Tissue microarrays were constructed with 265 samples of FNs (112 follicular carcinomas (FCs) and 153 follicular adenomas (FAs)) as well as 108 samples of HCNs (27 Hürthle cell carcinomas (HCCs) and 81 Hürthle cell adenomas (HCAs))...
2017: Disease Markers
https://www.readbyqxmd.com/read/28781416/noncoding-centromeric-rna-expression-impairs-chromosome-stability-in-human-and-murine-stem-cells
#5
David Y L Chan, Daniela Moralli, Suhail Khoja, Zoia L Monaco
We analyzed the effect of transcribed noncoding RNA centromeric satellites on chromosome segregation in normal human and murine stem and fibrosarcoma cells. The overexpression of different centromeric alphoid DNAs in all cell lines induced a marked increase in chromosome mis-segregation in anaphase. Overexpression of centromeric mouse minor satellite also increased chromosome instability in the murine stem but not in human cells. Analysis of chromosome segregation in vivo showed disturbances in the mitotic progression, which was frequently unresolved...
2017: Disease Markers
https://www.readbyqxmd.com/read/28769143/zonulin-a-potential-marker-of-intestine-injury-in-newborns
#6
Anna Tarko, Anna Suchojad, Marta Michalec, Małgorzata Majcherczyk, Aniceta Brzozowska, Iwona Maruniak-Chudek
INTRODUCTION: Zonulin (ZO), a new diagnostic biomarker of intestinal permeability, was tested in newborns presenting symptoms of infection and/or inflammation of the gut or being at risk of intestinal pathology. MATERIAL AND METHODS: Serum ZO was assessed in 81 newborns diagnosed with sepsis, necrotizing enterocolitis (NEC), rotavirus infection, and gastroschisis, also in extremely low gestational age babies, and in controls (healthy newborns). ZO concentration was compared to C-reactive protein (CRP) and procalcitonin (PCT) values, leucocyte and platelet count, basic demographic data, and the value of the Neonatal Therapeutic Intervention Scoring System (NTISS)...
2017: Disease Markers
https://www.readbyqxmd.com/read/28757678/microrna-expression-in-malignant-pleural-mesothelioma-and-asbestosis-a-pilot-study
#7
Paola Mozzoni, Luca Ampollini, Matteo Goldoni, Rossella Alinovi, Marcello Tiseo, Letizia Gnetti, Paolo Carbognani, Michele Rusca, Antonio Mutti, Antonio Percesepe, Massimo Corradi
BACKGROUND: The identification of diagnostic/prognostic biomarkers for asbestos-related diseases is relevant for early diagnosis and patient survival and may contribute to understanding the molecular mechanisms underlying the disease development and progression. AIMS: To identify a pattern of miRNAs as possible diagnostic biomarkers for patients with malignant pleural mesothelioma (MPM) and asbestosis (ASB) and as prognostic biomarkers for MPM patients. METHODS: miRNA-16, miRNA-17, miRNA-126, and miRNA-486 were quantified in plasma and formalin-fixed paraffin-embedded samples to evaluate their diagnostic and prognostic roles compared to patients with other noncancerous pulmonary diseases (controls)...
2017: Disease Markers
https://www.readbyqxmd.com/read/28757677/circulating-th1-th2-and-th17-levels-in-hypertensive-patients
#8
Qingwei Ji, Guojie Cheng, Ning Ma, Ying Huang, Yingzhong Lin, Qi Zhou, Bin Que, Jianzeng Dong, Yujie Zhou, Shaoping Nie
BACKGROUND: Evidence from experimental studies showed that Th1, Th2, and Th17 play a pivotal role in hypertension and target organ damage. However, whether changes in the circulating Th1, Th2, and Th17 levels are associated with nondipper hypertension and carotid atherosclerotic plaque in hypertension has yet to be investigated. METHODS: Th1, Th2, and Th17 levels were detected using a flow cytometric analysis, and their related cytokines were measured by enzyme-linked immunosorbent assay in 45 hypertensive patients and 15 normotensive subjects...
2017: Disease Markers
https://www.readbyqxmd.com/read/28757676/structure-and-function-of-enterocyte-in-intrauterine-growth-retarded-pig-neonates
#9
Karolina Ferenc, Tomasz Pilżys, Tomasz Skrzypek, Damian Garbicz, Michał Marcinkowski, Małgorzata Dylewska, Paweł Gładysz, Oleksandr Skorobogatov, Zdzisław Gajewski, Elżbieta Grzesiuk, Romuald Zabielski
The intestine of intrauterine growth retarded (IUGR) neonates showed different morphology compared to neonates born with normal body weight (NBW). The aim of the present study was to investigate the ultrastructure and proteomic profile of the gut epithelium in IUGR pig neonates with special attention to the digestive and absorptive function. Intestine tissue samples were investigated in 7-day-old IUGR and NBW littermate piglets using histometry, immunofluorescence, scanning electron microscopy (SEM), and mass spectrometry analysis...
2017: Disease Markers
https://www.readbyqxmd.com/read/28757675/association-of-gclm-588c-t-and-gclc-129t-c-promoter-polymorphisms-of-genes-coding-the-subunits-of-glutamate-cysteine-ligase-with-ischemic-heart-disease-development-in-kazakhstan-population
#10
Liliya Skvortsova, Anastasia Perfelyeva, Elmira Khussainova, Alma Mansharipova, Henry Jay Forman, Leyla Djansugurova
BACKGROUND: Glutamate cysteine ligase (GCL) is a rate-limiting enzyme in synthesis of glutathione. Evidence suggests that genetic variations in the promoter region of genes coding a catalytic subunit (GCLC -129T/C) and a modifier subunit (GCLM -588C/T) of GCL have a functional impact on their transcriptional activity and were associated with various disorders. Hence, we hypothesize whether these two polymorphic variants of GCLM and GCLC genes are associated with the risk of ischemic heart disease (IHD) development in the population of Kazakhstan...
2017: Disease Markers
https://www.readbyqxmd.com/read/28713192/foxp3-allelic-variants-and-haplotype-structures-are-associated-with-aggressive-breast-cancer-subtypes
#11
Bruna Karina Banin Hirata, Roberta Losi Guembarovski, Glauco Akelinghton Freire Vitiello, Alda Losi Guembarovski, Karen Brajão de Oliveira, Maria Angelica Ehara Watanabe
FOXP3 genetic polymorphisms have been associated with cancer development and prognosis. In this context, the present study aimed to evaluate the g.10403A>G (rs2232365) polymorphisms and g.8048A>C (rs3761548), in aggressive breast cancer (BC) subtypes, including, Luminal B HER2+ (LB), HER2-enriched (HER2+), and triple-negative (TN). Polymerase chain reaction followed by enzymatic restriction was performed to genotyping 117 BC samples and 300 controls. A significant association of AA genotype (g.10403A>G) in relation to BC susceptibility (OR = 1...
2017: Disease Markers
https://www.readbyqxmd.com/read/28701807/natriuretic-peptides-as-biomarkers-for-congestive-states-the-cardiorenal-divergence
#12
REVIEW
Abhilash Koratala, Amir Kazory
Congestion represents the primary reason for hospitalization of patients with heart failure and is associated with adverse outcomes. Fluid overload has been shown to be inadequately addressed in a significant subset of these patients in part due to lack of robust, reliable, and readily available biomarkers for objective assessment and monitoring of therapy. Natriuretic peptides have long been used in this setting, often in conjunction with other assessment tools such as imaging studies. Patients presenting with concomitant cardiac and renal dysfunction represent a unique population with regard to congestion in that the interactions between the heart and the kidney can affect the utility and performance of biomarkers of fluid overload...
2017: Disease Markers
https://www.readbyqxmd.com/read/28694560/peritransplant-soluble-cd30-as-a-risk-factor-for-slow-kidney-allograft-function-early-acute-rejection-worse-long-term-allograft-function-and-patients-survival
#13
Andriy V Trailin, Tetyana I Ostapenko, Tamara N Nykonenko, Svitlana N Nesterenko, Olexandr S Nykonenko
BACKGROUND: We aimed to determine whether serum soluble CD30 (sCD30) could identify recipients at high risk for unfavorable early and late kidney transplant outcomes. METHODS: Serum sCD30 was measured on the day of kidney transplantation and on the 4th day posttransplant. We assessed the value of these measurements in predicting delayed graft function, slow graft function (SGF), acute rejection (AR), pyelonephritis, decline of allograft function after 6 months, and graft and patient survival during 5 years of follow-up in 45 recipients...
2017: Disease Markers
https://www.readbyqxmd.com/read/28694559/association-of-single-nucleotide-polymorphisms-in-dc-sign-with-nasopharyngeal-carcinoma-susceptibility
#14
Sisi Li, Zhifang Lu, Mengwei Yao, Sisi Ning, Yuan Wu, Xunzhao Zhou, Changtao Zhong, Kui Yan, Ying Xie, Zhengbo Wei
The aim of this study was to explore potential relationships of four single-nucleotide polymorphisms (SNPs) in the gene encoding dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN) with risk of nasopharyngeal carcinoma (NPC). The DC-SIGN SNPs rs7252229, rs4804803, rs2287886, and rs735240 were genotyped in 477 unrelated NPC patients and 561 cancer-free controls. At rs7252229, risk of NPC was significantly lower in individuals with GC (odds ratio [OR] 0.076, 95% confidence interval [CI] 0...
2017: Disease Markers
https://www.readbyqxmd.com/read/28694558/impact-of-vaccination-on-distribution-of-t-cell-subsets-in-antiretroviral-treated-hiv-infected-children
#15
Premrutai Thitilertdecha, Ladawan Khowawisetsut, Palanee Ammaranond, Poonsin Poungpairoj, Varangkana Tantithavorn, Nattawat Onlamoon
Antiretroviral therapy (ART) is generally prescribed to patients with human immunodeficiency virus (HIV) infection with vaccination introduced to prevent disease complications. However, little is known about the influence of immunization on T cell subsets' distribution during the course of infection. This study aims to identify the impact of viral replication and immunization on naïve, effector, effector memory, and central memory T cell subpopulations in ART-treated HIV-infected children. Fifty patients were recruited and injected intramuscularly with influenza A (H1N1) 2009 vaccine on the day of enrollment (day 0) and day 28...
2017: Disease Markers
https://www.readbyqxmd.com/read/28694557/overexpression-of-mir-24-is-involved-in-the-formation-of-hypocoagulation-state-after-severe-trauma-by-inhibiting-the-synthesis-of-coagulation-factor-x
#16
Lu-Jia Chen, Lian Yang, Xing Cheng, Yin-Kai Xue, Li-Bo Chen
BACKGROUND: Dysregulation of microRNAs may contribute to the progression of trauma-induced coagulopathy (TIC). We aimed to explore the biological function that miRNA-24-3p (miR-24) might have in coagulation factor deficiency after major trauma and TIC. METHODS: 15 healthy volunteers and 36 severe trauma patients (Injury Severity Score ≥ 16 were enrolled. TIC was determined as the initial international normalized ratio >1.5. The miR-24 expression and concentrations of factor X (FX) and factor XII in plasma were measured...
2017: Disease Markers
https://www.readbyqxmd.com/read/28684886/eg5-overexpression-is-predictive-of-poor-prognosis-in-hepatocellular-carcinoma-patients
#17
Can Liu, Nan Zhou, Jieying Li, Jun Kong, Xi Guan, Xudong Wang
Eg5 (kinesin spindle protein) plays an essential role in mitosis. Inhibition of Eg5 function results in cell cycle arrest at mitosis, which leads to cell death. To date, Eg5 expression and its prognostic significance have not been studied in hepatocellular carcinoma (HCC). In this study, 26 freshly frozen HCC tissue samples and matched peritumoral tissue samples were evaluated with a one-step qPCR test and immunohistochemical (IHC) analysis was conducted on 156 HCC samples to investigate the relationships among Eg5 expression, clinicopathological factors, and prognosis...
2017: Disease Markers
https://www.readbyqxmd.com/read/28676731/the-ratio-of-c-reactive-protein-albumin-is-a-novel-inflammatory-predictor-of-overall-survival-in-cisplatin-based-treated-patients-with-metastatic-nasopharyngeal-carcinoma
#18
Peng Sun, Cui Chen, Yi Xia, Xiwen Bi, Panpan Liu, Fei Zhang, Hang Yang, Xin An, Wenqi Jiang, Fenghua Wang
The C-reactive protein/albumin (CRP/Alb) ratio has been recently identified as a prognostic factor in various cancers, whereas its role remains unclear in metastatic nasopharyngeal carcinoma (NPC). The current study retrospectively analyzed 148 patients with metastatic NPC who underwent cisplatin-based chemotherapy and further evaluated the prognostic value of the CRP/Alb ratio and its association with clinical characteristics in these patients. The optimal cut-off value was 0.189 for the CRP/Alb ratio. The high CRP/Alb ratio was significantly associated with elevated NLR, platelet-to-lymphocyte ratio (PLR), and EBV-DNA levels and decreased haemoglobin level (all p < 0...
2017: Disease Markers
https://www.readbyqxmd.com/read/28659657/serum-gamma-glutamyl-transferase-and-ferritin-synergistically-associated-with-the-rate-of-chronic-kidney-disease
#19
Tao Chen, Yan Ren, Yun Gao, Haoming Tian
The present study investigated the effects of GGT and SF on the risk of CKD. 1024 participants (436 men and 588 women) were divided into three groups according to GGT and SF levels: group 1 (both GGT and SF not in the fourth quartile), group 2 (only GGT or SF in the fourth quartile), and group 3 (both GGT and SF in the fourth quartile). The risks of CKD in different levels of GGT and SF and in groups 2-3 compared with group 1 were analyzed by multiple logistic regression. GGT or SF in the highest quartile was associated with increased risk of CKD...
2017: Disease Markers
https://www.readbyqxmd.com/read/28659656/type-ii-endometrial-cancer-overexpresses-nilco-a-preliminary-evaluation
#20
Danielle Daley-Brown, Gabriela Oprea-Iles, Kiara T Vann, Viola Lanier, Regina Lee, Pierre V Candelaria, Alexander Quarshie, Roland Pattillo, Ruben Rene Gonzalez-Perez
OBJECTIVE: The expression of NILCO molecules (Notch, IL-1, and leptin crosstalk outcome) and the association with obesity were investigated in types I and II endometrial cancer (EmCa). Additionally, the involvement of NILCO in leptin-induced invasiveness of EmCa cells was investigated. METHODS: The expression of NILCO mRNAs and proteins were analyzed in EmCa from African-American (n = 29) and Chinese patients (tissue array, n = 120 cases). The role of NILCO in leptin-induced invasion of Ishikawa and An3ca EmCa cells was investigated using Notch, IL-1, and leptin signaling inhibitors...
2017: Disease Markers
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