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Disease Markers

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https://www.readbyqxmd.com/read/28512385/association-of-pecam-1-gene-polymorphisms-with-kawasaki-disease-in-chinese-children
#1
Zhuoying Li, Dong Han, Jie Jiang, Jia Chen, Lang Tian, Zuocheng Yang
Kawasaki disease (KD) is an acute systemic vasculitis complicated by development of coronary artery lesions. PECAM-1 is a kind of cell adhesion molecule, which plays an important role in coronary artery disease. The relationship between PECAM-1 gene polymorphisms and their susceptibility to Kawasaki diseases (KD) is still unclear. In our study, we examined the PECAM-1 gene polymorphisms in 44 KD patients and 59 healthy children and revealed the correlation of PECAM-1 gene polymorphisms in KD children with and without coronary artery lesions (CAL)...
2017: Disease Markers
https://www.readbyqxmd.com/read/28487599/mir-195-regulates-proliferation-and-apoptosis-through-inhibiting-the-mtor-p70s6k-signaling-pathway-by-targeting-hmga2-in-esophageal-carcinoma-cells
#2
Yong Li, Dapeng Wu, Pei Wang, Xiaohui Li, Gongning Shi
miR-195 is related to tumorigenesis and frequently inhibits cell proliferation and promotes apoptosis in various cancers, including esophageal carcinoma (EC). The mTOR/p70s6k signaling pathway, which is the major target pathway for HMGA2, regulates the survival and cell proliferation of many tumors and is commonly active in EC. The relationships of miR-195, HMGA2, and the mTOR/p70s6k signaling pathway in EC, however, remain unknown. In the present study, we found that the miR-195 level was significantly downregulated in EC tissues, while the mRNA expressions of HMGA2 were significantly upregulated...
2017: Disease Markers
https://www.readbyqxmd.com/read/28487598/potential-hepatoprotective-role-of-galectin-3-during-hcv-infection-in-end-stage-renal-disease-patients
#3
Ruzica Lukic, Nevena Gajovic, Ivan Jovanovic, Milena Jurisevic, Zeljko Mijailovic, Veljko Maric, Biljana Popovska Jovicic, Nebojsa Arsenijevic
Hepatitis C virus infection (HCV), one of the greatest causes of liver disease, is a frequent complication in patients with end-stage renal disease (ESRD) on dialysis. ESRD is defined as decreased glomerular filtration and also accompanied by impaired function of the immune system. Galectin-3 is a β-galactoside-binding lectin, involved in various biological processes including pathogenesis of chronic renal disease. The aim of our study was to estimate disease severity in ESRD HCV(+) patients and analyze the serum concentrations of IL-1β, IL-4, IL-23, and IL-6; anti-HCV antibodies; and galectin-3...
2017: Disease Markers
https://www.readbyqxmd.com/read/28484288/association-between-vegf-gene-polymorphisms-and-in-stent-restenosis-after-coronary-intervention-treated-with-bare-metal-stent
#4
Zsolt Bagyura, Loretta Kiss, Kristóf Hirschberg, Balázs Berta, Gábor Széplaki, Árpád Lux, Zsolt Szelid, Pál Soós, Béla Merkely
Background. In-stent restenosis (ISR) is the gradual narrowing of the vessel lumen after coronary stent implantation due to the increase in vascular smooth muscle cell proliferation. Vascular endothelial growth factor (VEGF) protein plays an important role in this process. Our aim was to analyze the association of single nucleotide polymorphisms of the VEGF gene (rs2010963 and rs6999447) with the occurrence of ISR after coronary artery bare metal stent (BMS) implantation. Methods. 205 patients with a history of BMS implantation and a repeated coronarography were prospectively enrolled...
2017: Disease Markers
https://www.readbyqxmd.com/read/28484287/mir-135b-plays-a-neuroprotective-role-by-targeting-gsk3%C3%AE-in-mpp-intoxicated-sh-sy5y-cells
#5
Jianlei Zhang, Wei Liu, Yabo Wang, Shengnan Zhao, Na Chang
miR-135a-5p was reported to play a crucial role in the protective effects of hydrogen sulfide against Parkinson's disease (PD) by targeting rho-associated protein kinase 2 (ROCK2). However, the role of another member of miR-135 family (miR-135b) and the underlying mechanism in PD are still unclear. qRT-PCR and western blot showed that miR-135 was downregulated and glycogen synthase kinase 3β (GSK3β) was upregulated at mRNA and protein levels in MPP(+)-intoxicated SH-SY5Y cells in a dose- and time-dependent manner...
2017: Disease Markers
https://www.readbyqxmd.com/read/28458444/functional-analysis-of-the-coronary-heart-disease-risk-locus-on-chromosome-21q22
#6
Katherine E Beaney, Andrew J P Smith, Lasse Folkersen, Jutta Palmen, S Goya Wannamethee, Barbara J Jefferis, Peter Whincup, Tom R Gaunt, Juan P Casas, Yoav Ben-Shlomo, Jacqueline F Price, Meena Kumari, Andrew Wong, Ken Ong, Rebecca Hardy, Diana Kuh, Nicholas Wareham, Mika Kivimaki, Per Eriksson, Steve E Humphries, Ucleb Consortium
Background. The coronary heart disease (CHD) risk locus on 21q22 (lead SNP rs9982601) lies within a "gene desert." The aim of this study was to assess if this locus is associated with CHD risk factors and to identify the functional variant(s) and gene(s) involved. Methods. A phenome scan was performed with UCLEB Consortium data. Allele-specific protein binding was studied using electrophoretic mobility shift assays. Dual-reporter luciferase assays were used to assess the impact of genetic variation on expression...
2017: Disease Markers
https://www.readbyqxmd.com/read/28408773/can-mitochondria-dna-provide-a-novel-biomarker-for-evaluating-the-risk-and-prognosis-of-colorectal-cancer
#7
REVIEW
Han Shuwen, Yang Xi, Pan Yuefen
Colorectal cancer (CRC) was one of the most frequent cancers worldwide. Accurate risk and prognosis evaluation could obtain better quality of life and longer survival time for the patients. Current research hotspot was focus on the gene biomarker to evaluate the risk and prognosis. Mitochondrion contains its own DNA and regulates self-replicating so that it can be as a candidate biomarker for evaluating the risk and prognosis of colorectal cancer. But there were already huge controversies on this issue. The review was to summarize current viewpoints of the controversial issues and described our understanding from the four aspects including mtDNA copy number, mitochondrial displacement loop, mtDNA variation, and mtDNA microsatellite instability, wishing the summary of the mtDNA in colorectal cancer could provide a meaningful reference or a valuable direction in the future studies...
2017: Disease Markers
https://www.readbyqxmd.com/read/28396612/efficacy-of-nucleot-s-ide-analogs-therapy-in-patients-with-unresectable-hbv-related-hepatocellular-carcinoma-a-systematic-review-and-meta-analysis
#8
REVIEW
Lingling He, Xiaoli Liu, Yalin Zhao, Shuan Zhang, Yuyong Jiang, Xianbo Wang, Zhiyun Yang
Aim. To determine whether nucleot(s)ide analogs therapy has survival benefit for patients with HBV-related HCC after unresectable treatment. Method. A systematic search was conducted through seven electronic databases including PubMed, OVID, EMBASE, Cochrane Databases, Elsevier, Wiley Online Library, and BMJ Best Practice. All studies comparing NA combined with unresectable treatment versus unresectable treatment alone were considered for inclusion. The primary outcome was the overall survival (OS) after unresectable treatment for patients with HBV-related HCC...
2017: Disease Markers
https://www.readbyqxmd.com/read/28392616/association-between-il-4-and-il-4r-polymorphisms-and-periodontitis-a-meta-analysis
#9
REVIEW
Xiao-Wei Jia, Ya-Di Yuan, Zhong-Xiong Yao, Chang-Jing Wu, Xiang Chen, Xue-Hong Chen, Ying-Mei Lin, Xiang-Yu Meng, Xian-Tao Zeng, Jun Shao
Background. Previous studies have revealed that gene polymorphisms of inflammatory factors may influence the development or progression of periodontitis, a main cause of tooth loss in adults; however, due to limitations of individual studies, inconsistent findings were reported. Objective. To meta-analytically investigate the relationship between periodontitis and the Interleukin-4 (IL-4) and Interleukin-4 receptor (IL-4R) gene polymorphisms. Methods. Databases were searched for relevant case-control studies...
2017: Disease Markers
https://www.readbyqxmd.com/read/28386156/genotyping-of-il-4-590-c-t-gene-in-iraqi-asthma-patients
#10
Ihsan A Hussein, Saddam H Jaber
This study is the first investigation in Iraq dealing with genotyping of IL-4 -590 (C>T) gene, especially in Iraqi patients with asthma. We studied forty-eight blood samples collected from patients with asthma and compared with age-matched 25 healthy individuals as controls. The polymorphism results of IL-4 -590 (C>T) gene by using amplification refractory mutation system (ARMS-PCR) showed the presence of C and T alleles and three genotypes (CC, CT, and TT). Interestingly the frequency of C allele and CC genotype was higher in patients with asthma in comparison with the same allele and genotype in control (P 1 × 10(-6))...
2017: Disease Markers
https://www.readbyqxmd.com/read/28386155/corrigendum-to-predictive-value-of-plasma-microrna-216a-b-in-the-diagnosis-of-esophageal-squamous-cell-carcinoma
#11
Shuling Dong, Huiqing Yin, Cuicui Dong, Kaiyan Sun, Pin Lv, Weiwei Meng, Liang Ming, Fucheng He
[This corrects the article DOI: 10.1155/2016/1857067.].
2017: Disease Markers
https://www.readbyqxmd.com/read/28386154/the-exploration-of-peptide-biomarkers-in-malignant-pleural-effusion-of-lung-cancer-using-matrix-assisted-laser-desorption-ionization-time-of-flight-mass-spectrometry
#12
Jing Xu, Bin Xu, Chuanhao Tang, Xiaoyan Li, Haifeng Qin, Weixia Wang, Hong Wang, Zhongyuan Wang, Liangliang Li, Zhihua Li, Hongjun Gao, Kun He, Xiaoqing Liu
Background. Diagnoses of malignant pleural effusion (MPE) are a crucial problem in clinics. In our study, we compared the peptide profiles of MPE and tuberculosis pleural effusion (TPE) to investigate the value of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) in diagnosis of MPE. Material and Methods. The 46 MPE and 32 TPE were randomly assigned to training set and validation set. Peptides were isolated by weak cation exchange magnetic beads and peaks in the m/z range of 800-10000 Da were analyzed...
2017: Disease Markers
https://www.readbyqxmd.com/read/28356610/a-panel-of-ca19-9-ca125-and-ca15-3-as-the-enhanced-test-for-the-differential-diagnosis-of-the-pancreatic-lesion
#13
Piotr Hogendorf, Aleksander Skulimowski, Adam Durczyński, Anna Kumor, Grażyna Poznańska, Aleksandra Oleśna, Joanna Rut, Janusz Strzelczyk
Background. Proper diagnosis of pancreatic lesion etiology is a challenging clinical dilemma. Studies suggest that surgery for suspected pancreatic ductal adenocarcinoma (PDAC) reveals a benign lesion in 5% to 13% of cases. The aim of our study was to assess whether routinely used biomarkers such as CA19-9, Ca125, Ca15-3, and CEA, when combined, can potentially yield an accurate test predicting pancreatic lesion etiology. Methods. We retrospectively analyzed data of 326 patients who underwent a diagnostic process due to pancreatic lesions of unknown etiology...
2017: Disease Markers
https://www.readbyqxmd.com/read/28356609/ischemia-modified-albumin-as-a-marker-of-acute-coronary-syndrome-the-case-for-revising-the-concept-of-n-terminal-modification-to-fatty-acid-occupation-of-albumin
#14
REVIEW
Ismail Oran, Bulent Oran
Ischemia-modified albumin (IMA) is assumed "N-terminal modified" albumin which is generated immediately following myocardial ischemia. The diagnosis of IMA is based on reduced cobalt binding affinity to albumin which is attributed mainly to incapability of cobalt to bind at albumin's modified N-terminus. Although the albumin cobalt binding test was accepted as a potentially powerful marker for discriminating acute coronary syndrome from nonischemic chest pain, its usefulness has been brought into question in recent years...
2017: Disease Markers
https://www.readbyqxmd.com/read/28348452/hyperferritinemia-as-a-diagnostic-marker-for-severe-fever-with-thrombocytopenia-syndrome
#15
Uh Jin Kim, Tae Hoon Oh, Bansuk Kim, Seong Eun Kim, Seung-Ji Kang, Kyung-Hwa Park, Sook-In Jung, Hee-Chang Jang
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging viral disease in East Asia with high mortality. Few studies have examined markers that suggest SFTS in febrile patients. To determine useful biochemical markers for SFTS, patients aged 18 years or older with SFTS or microbiologically confirmed community-onset bacteremia with thrombocytopenia (BT) at presentation between June 2013 and December 2015 were included from two tertiary university hospitals in Republic of Korea retrospectively. Eleven patients with SFTS and 62 patients with bacteremia and thrombocytopenia were identified in the study period...
2017: Disease Markers
https://www.readbyqxmd.com/read/28348451/serum-hmgb1-as-a-potential-biomarker-for-patients-with-asbestos-related-diseases
#16
Shibo Ying, Zhaoqiang Jiang, Xianglei He, Min Yu, Riping Chen, Junqiang Chen, Guoqing Ru, Yuan Chen, Wanyuan Chen, Lijin Zhu, Tao Li, Yixiao Zhang, Xinnian Guo, Xianhong Yin, Xing Zhang, Jianlin Lou
High-mobility group box 1 (HMGB1) functions as a proinflammatory cytokine and is one of the most intriguing molecules in inflammatory disorders and cancers. Notably, HMGB1 is a potential therapeutic target and novel biomarker in related diseases. However, the diagnostic value of HMGB1 for benign and malignant asbestos-related diseases (ARDs) remains unclear. In this work, we detected preoperative serum HMGB1 levels in Chinese asbestos-exposed (AE) and ARDs populations and further evaluated the diagnostic value of HMGB1 in patients with certain types of ARDs, including those with pleural plaques, asbestosis, or malignant mesothelioma (MM)...
2017: Disease Markers
https://www.readbyqxmd.com/read/28348450/a-novel-panel-of-serum-biomarkers-for-mpm-diagnosis
#17
A Bonotti, R Foddis, S Landi, O Melaiu, C De Santi, L Giusti, E Donadio, F Ciregia, M R Mazzoni, A Lucacchini, M Bovenzi, M Comar, E Pantani, A Pistelli, A Cristaudo
Exposure to asbestos is the main cause of malignant pleural mesothelioma (MPM), a highly aggressive cancer of the pleura. Since the only tools for early detection are based on radiological tests, some authors focused on serum markers (i.e., mesothelin). The aim of this study was the evaluation of new serum biomarkers to be used individually or in combination, in order to improve the outcome of patients whose disease would be diagnosed at an earlier stage. Serum and plasma were available from 43 subjects previously exposed to asbestos and 27 MPM patients, all being epithelioid type...
2017: Disease Markers
https://www.readbyqxmd.com/read/28348449/combined-genetic-biomarkers-confer-susceptibility-to-risk-of-urothelial-bladder-carcinoma-in-a-saudi-population
#18
Nasser Attia Elhawary, Anmar Nassir, Hesham Saada, Anas Dannoun, Omar Qoqandi, Ammar Alsharif, Mohammed Taher Tayeb
We evaluated the associations between seven single nucleotide polymorphisms and susceptibility to urothelial bladder carcinoma (UBC) in a Saudi population. Genomic DNA was taken from buccal cells of 52 patients with UBC and 104 controls for genotyping of GSTT1, GSTM1, rs4646903, rs1048943, TP53 rs1042522, rs1801133, and rs1801394 using PCR and TaqMan® assays. The rs1801133 and rs1801394 variants showed strong associations with UBC (OR = 2.3, P = 0.0002; OR = 2.6, P = 0.0001, resp.). Homozygosity of Pro72 conferred a significant double risk in cases compared with controls (30...
2017: Disease Markers
https://www.readbyqxmd.com/read/28337048/validity-of-a-new-kit-measuring-salivary-lactate-dehydrogenase-level-for-screening-gingivitis
#19
Daisuke Ekuni, Mayu Yamane-Takeuchi, Kota Kataoka, Aya Yokoi, Ayano Taniguchi-Tabata, Hirofumi Mizuno, Hisataka Miyai, Yoko Uchida, Daiki Fukuhara, Yoshio Sugiura, Takaaki Tomofuji, Manabu Morita
Aim. The aim of this study was to determine the usefulness of a new kit that can evaluate salivary lactate dehydrogenase (LD) level in real time for screening gingivitis. Materials and Methods. The study included 70 systemic healthy volunteers [29 males and 41 females; mean age ± SD: 24.1 ± 2.6 years]. Resting saliva was collected from each participant and LD level was evaluated in real time using the kit (a color-changing sheet with an integer scale ranging from 1 to 10). A dentist measured probing pocket depth, clinical attachment level, and the proportion of sites with bleeding on probing (% BOP) at six sites on all teeth...
2017: Disease Markers
https://www.readbyqxmd.com/read/28325958/micrornas-involvement-in-radioresistance-of-head-and-neck-cancer
#20
REVIEW
Parwez Ahmad, Jiri Sana, Marek Slavik, Pavel Slampa, Pavel Smilek, Ondrej Slaby
Resistance to the ionizing radiation is a current problem in the treatment and clinical management of various cancers including head and neck cancer. There are several biological and molecular mechanisms described to be responsible for resistance of the tumors to radiotherapy. Among them, the main mechanisms include alterations in intracellular pathways involved in DNA damage and repair, apoptosis, proliferation, and angiogenesis. It has been found that regulation of these complex processes is often controlled by microRNAs...
2017: Disease Markers
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