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Disease Markers

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https://www.readbyqxmd.com/read/28325958/micrornas-involvement-in-radioresistance-of-head-and-neck-cancer
#1
REVIEW
Parwez Ahmad, Jiri Sana, Marek Slavik, Pavel Slampa, Pavel Smilek, Ondrej Slaby
Resistance to the ionizing radiation is a current problem in the treatment and clinical management of various cancers including head and neck cancer. There are several biological and molecular mechanisms described to be responsible for resistance of the tumors to radiotherapy. Among them, the main mechanisms include alterations in intracellular pathways involved in DNA damage and repair, apoptosis, proliferation, and angiogenesis. It has been found that regulation of these complex processes is often controlled by microRNAs...
2017: Disease Markers
https://www.readbyqxmd.com/read/28325957/heat-shock-protein-hsp27-secretion-by-ovarian-cancer-cells-is-linked-to-intracellular-expression-levels-occurs-independently-of-the-endoplasmic-reticulum-pathway-and-hsp27-s-phosphorylation-status-and-is-mediated-by-exosome-liberation
#2
Matthias B Stope, Gerd Klinkmann, Karoline Diesing, Dominique Koensgen, Martin Burchardt, Alexander Mustea
The heat shock protein HSP27 has been correlated in ovarian cancer (OC) patients with aggressiveness and chemoresistance and, therefore, represents a promising potential biomarker for OC diagnosis, prognosis, and treatment response. Notably, secretion of soluble HSP27 has been described by a few cell types and may take place as well in OC cells. Therefore, we studied HSP27 secretion mechanisms under diverse cellular conditions in an OC cell model system. Secretion of HSP27 was characterized after overexpression of HSP27 by transfected plasmids and after heat shock...
2017: Disease Markers
https://www.readbyqxmd.com/read/28321148/circulating-mir-132-3p-as-a-candidate-diagnostic-biomarker-for-malignant-mesothelioma
#3
Daniel G Weber, Katarzyna Gawrych, Swaantje Casjens, Alexander Brik, Martin Lehnert, Dirk Taeger, Beate Pesch, Jens Kollmeier, Torsten T Bauer, Georg Johnen, Thomas Brüning
The use of circulating microRNAs as biomarkers has opened new opportunities for diagnosis of cancer because microRNAs exhibit tumor-specific expression profiles. The aim of this study was the identification of circulating microRNAs in human plasma as potential biomarkers for the diagnosis of malignant mesothelioma. For discovery, TaqMan Low Density Array Human MicroRNA Cards were used to analyze 377 microRNAs in plasma samples from 21 mesothelioma patients and 21 asbestos-exposed controls. For verification, individual TaqMan microRNA assays were used for quantitative real-time PCR in plasma samples from 22 mesothelioma patients and 44 asbestos-exposed controls...
2017: Disease Markers
https://www.readbyqxmd.com/read/28321147/detection-of-circulating-tumour-cells-in-urothelial-cancers-and-clinical-correlations-comparison-of-two-methods
#4
Emanuela Fina, Andrea Necchi, Stefano Bottelli, Carolina Reduzzi, Sara Pizzamiglio, Chiara Iacona, Maria Grazia Daidone, Paolo Verderio, Vera Cappelletti
Circulating tumour cells (CTC) are identified exploiting their protein/gene expression patterns or distinct size compared to blood cells. Data on CTC in bladder cancer (BC) are still scarce. We comparatively analyzed CTC enrichment by AdnaTest ProstateCancerSelect (AT) and ScreenCell®Cyto (SC) kits, combined with identification by EPCAM, MUC1, and ERBB2 expression and by cytological criteria, respectively, in 19 nonmetastatic (M0) and 47 metastatic (M+) BC patients, at baseline (T0) and during treatment (T1)...
2017: Disease Markers
https://www.readbyqxmd.com/read/28316362/association-of-circulating-igfbp1-level-with-the-severity-of-coronary-artery-lesions-in-patients-with-unstable-angina
#5
Wei Zheng, Yayu Lai, Peng Jin, Wenzhu Gu, Qi Zhou, Xiaojing Wu
Aims. Local IGFBP1 level was reported to affect the development of coronary artery plaque. This study investigated the association of circulating IGFBP1 level with the severity of coronary artery lesions in patients with unstable angina. Materials and Methods. In 112 consecutive patients with clinically diagnosed unstable angina, admitted from July 2014 to July 2015, we studied the correlations of circulating IGFBP1 and the severity of coronary artery disease (CAD). Results. All patients underwent scheduled coronary angiography, and 67 cases were diagnosed with critical and 45 with noncritical CAD...
2017: Disease Markers
https://www.readbyqxmd.com/read/28298809/predictive-value-of-mir-219-1-mir-938-mir-34b-c-and-mir-218-polymorphisms-for-gastric-cancer-susceptibility-and-prognosis
#6
Yanhua Wu, Zhifang Jia, Donghui Cao, Chuan Wang, Xing Wu, Lili You, Simin Wen, Yuchen Pan, Xueyuan Cao, Jing Jiang
Gastric cancer (GC) is one of the most prominent global cancer-related health threats. Genes play a key role in the precise mechanisms of gastric cancer. SNPs in mi-RNAs could affect mRNA expression and then affect the risk and prognosis of GC. Firstly, we have decided to perform a case-control study which included 897 GC patients and 992 controls to evaluate the association of miR-219-1 rs213210, miR-938 rs2505901, miR-34b/c rs4938723, and miR-218 rs11134527 polymorphisms with gastric cancer susceptibility...
2017: Disease Markers
https://www.readbyqxmd.com/read/28298808/diagnostic-value-of-autoantibodies-against-ezrin-in-esophageal-squamous-cell-carcinoma
#7
Lan Li, Ming Liu, Jian-Bang Lin, Xin-Bin Hong, Wen-Xia Chen, Hong Guo, Li-Yan Xu, Yi-Wei Xu, En-Min Li, Yu-Hui Peng
Esophageal squamous cell carcinoma (ESCC), one of the most common malignancies worldwide, is a highly aggressive and homogeneous entity occurring in esophageal squamous epithelium, and a reliable noninvasive test for early detection is needed. A recent study showed that serum autoantibodies against Ezrin could be detected in patients with pancreatic cancer. Here, we assessed whether autoantibodies against Ezrin could have diagnostic relevance for early ESCC. We analyzed autoantibodies against Ezrin in sera of 98 normal controls and 149 patients with ESCC...
2017: Disease Markers
https://www.readbyqxmd.com/read/28298807/diagnostic-value-of-cyfra-21-1-in-the-cerebrospinal-fluid-for-leptomeningeal-metastasis
#8
Zhen Zhang, Chenglin Tian, Qiang Shi, Jing Hao, Na Zhao, Zhijie Liu
Cerebrospinal fluid (CSF) cytology has low sensitivity for leptomeningeal metastasis (LM); thus, new markers are needed to improve the diagnostic accuracy of LM. We measured carcinoembryonic antigen (CEA) and cytokeratin 19 fragments (CYFRA 21-1) in paired samples of CSF and serum from patients with LM and patients with nonmalignant neurological diseases (NMNDs) as controls. Receiver operating curve analysis was performed to assess their diagnostic accuracy for LM. In patients with NMNDs, CEA and CYFRA 21-1 levels in the CSF were significantly lower than the serum levels...
2017: Disease Markers
https://www.readbyqxmd.com/read/28293063/evaluation-of-prognostic-and-predictive-significance-of-circulating-micrornas-in-ovarian-cancer-patients
#9
Ann Rita Halvorsen, Gunnar Kristensen, Andy Embleton, Cybil Adusei, Maria Pilar Barretina-Ginesta, Philip Beale, Åslaug Helland
Ovarian cancer patients are recognized with poor prognosis. This study aimed to identify microRNAs in plasma for predicting response to treatment and outcome. We have investigated microRNAs in plasma from ovarian cancer patients enrolled in a large multicenter study (ICON7), investigating the effect of adding bevacizumab to standard chemotherapy in patients diagnosed with epithelial ovarian cancer. Patients with different histology, grade, and FIGO stages were included (n = 207) in this study. Screening of 754 unique microRNAs was performed in the discovery phase (n = 91) using TaqMan Low Density Arrays...
2017: Disease Markers
https://www.readbyqxmd.com/read/28293062/near-infrared-spectroscopy-reveals-abnormal-hemodynamics-in-the-left-dorsolateral-prefrontal-cortex-of-menopausal-depression-patients
#10
Xiang-Yun Ma, Yong-Jun Wang, Bo Xu, Kun Feng, Gao-Xiang Sun, Xiao-Qian Zhang, Xiao-Min Liu, Chen-Yu Shen, Xia-Jin Ren, Jing-Jing Sun, Po-Zi Liu
Background/Objective. Menopausal depression (MD) is characterized by depressive symptoms along with hormonal fluctuations. We investigate brain function alteration between major depressive disorder (MDD) and MD. Methods. The difference in oxygenated hemoglobin (Oxy-Hb) for the prefrontal cortex (PFC) was compared retrospectively among 90 females presented with 30 MDD, 30 MD, and 30 healthy controls (HCs) using verbal fluency task (VFT) with near-infrared spectroscopy (NIRS). Results. We observed a significant difference in Oxy-Hb alteration in the left dorsolateral PFC (DLPFC) using VFT with NIRS (channel 18, P = 0...
2017: Disease Markers
https://www.readbyqxmd.com/read/28286356/the-impact-of-tagsnps-in-cxcl16-gene-on-the-risk-of-myocardial-infarction-in-a-chinese-han-population
#11
Shun Xu, Jie Cheng, Meng-Yun Cai, Li-Li Liang, Jin-Ming Cen, Xi-Li Yang, Can Chen, Xinguang Liu, Xing-Dong Xiong
CXCL16 has been demonstrated to be involved in the development of atherosclerosis and myocardial infarction (MI). Nonetheless, the role of the CXCL16 polymorphisms on MI pathogenesis is far to be elucidated. We herein genotyped four tagSNPs in CXCL16 gene (rs2304973, rs1050998, rs3744700, and rs8123) in 275 MI patients and 670 control subjects, aimed at probing into the impact of CXCL16 polymorphisms on individual susceptibility to MI. Multivariate logistic regression analysis showed that C allele (OR = 1.31, 95% CI = 1...
2017: Disease Markers
https://www.readbyqxmd.com/read/28260828/differential-site-based-expression-of-pentose-phosphate-pathway-related-proteins-among-breast-cancer-metastases
#12
Yoon Jin Cha, Woo Hee Jung, Ja Seung Koo
Purpose. We aimed to investigate the expression of pentose phosphate pathway- (PPP-) related proteins in metastatic breast cancer and its relationship with clinicopathologic factors. Methods. Tissue samples from 126 metastatic breast cancers were included in a tissue microarray. Expression of PPP-related proteins [glucose-6-phosphate dehydrogenase (G6PDH), 6-phosphogluconolactonase (6PGL), 6-phosphogluconate dehydrogenase (6PGDH), and nuclear factor erythroid 2-related factor (NRF2)] was determined by immunohistochemistry...
2017: Disease Markers
https://www.readbyqxmd.com/read/28255193/the-impact-of-the-expression-level-of-intratumoral-dihydropyrimidine-dehydrogenase-on-chemotherapy-sensitivity-and-survival-of-patients-in-gastric-cancer-a-meta-analysis
#13
REVIEW
Cong Zhang, Hongpeng Liu, Bin Ma, Yongxi Song, Peng Gao, Yingying Xu, Dehao Yu, Zhenning Wang
The potential impact that the intratumoral expression level of dihydropyrimidine dehydrogenase (DPD) has on chemotherapy sensitivity and long-term survival for gastric cancer (GC) patients remains controversial; therefore, this study seeks to clarify this issue. Our meta-analysis was performed using Review Manager (RevMan) 5.3 software. In vitro drug sensitivity tests, correlation coefficients between sensitivity to 5-fluorouracil (5-FU), and expression levels of intratumoral DPD were used as effective indexes to analyse...
2017: Disease Markers
https://www.readbyqxmd.com/read/28255192/elevated-concentrations-of-serpine2-protease-nexin-1-and-secretory-leukocyte-protease-inhibitor-in-the-serum-of-patients-with-papillary-thyroid-cancer
#14
Tomasz Stępień, Mateusz Brożyna, Krzysztof Kuzdak, Ewelina Motylewska, Jan Komorowski, Henryk Stępień, Hanna Ławnicka
Introduction. SERPINE2 and secretory leukocyte protease inhibitor (SLPI) are proteins with anticoagulant properties which could promote solid tumor growth. However, their role in the pathogenesis of thyroid cancer has not been determined. Materials and Methods. The aim of this study was to assess serum SERPINE2 and SLPI concentrations in a group of 36 patients with papillary thyroid cancer (PTC) and a group of 19 subjects with multinodular nontoxic goiter (MNG). The control group (CG) consisted of 20 healthy volunteers...
2017: Disease Markers
https://www.readbyqxmd.com/read/28246425/influence-of-il-18-and-il-10-polymorphisms-on-tacrolimus-elimination-in-chinese-lung-transplant-patients
#15
Xiaoqing Zhang, Jiandong Xu, Junwei Fan, Tao Zhang, Yuping Li, Boxiong Xie, Wei Zhang, Shengtao Lin, Ling Ye, Yuan Liu, Gening Jiang
Aims. The influence of interleukin-10 (IL-10) and interleukin-18 (IL-18) polymorphisms on tacrolimus pharmacokinetics had been described in liver and kidney transplantation. The expression of cytokines varied in different kinds of transplantation. The influence of IL-10 and IL-18 genetic polymorphisms on the pharmacokinetic parameters of tacrolimus remains unclear in lung transplantation. Methods. 51 lung transplant patients at Shanghai Pulmonary Hospital were included. IL-18 polymorphisms (rs5744247 and rs1946518), IL-10 polymorphisms (rs1800896, rs1800872, and rs3021097), and CYP3A5 rs776746 were genotyped...
2017: Disease Markers
https://www.readbyqxmd.com/read/28203040/a-case-control-study-of-the-association-between-polymorphisms-in-the-fibrinogen-alpha-chain-gene-and-schizophrenia
#16
Wenwang Rao, Na Zhou, Huiping Zhang, Rui Liu, Shangchao Zhang, Yingying Su, Guang Yang, Yue Ma, Jieping Shi, Yaqin Yu, Qiong Yu
Our previous studies using the mass spectrum analysis provided evidence that fibrinopeptide A (FPA) could be a potential biomarker for schizophrenia diagnosis. We sought further to demonstrate that variants in the fibrinogen alpha chain gene (FGA) coded FPA might confer vulnerability to schizophrenia. 1,145 patients with schizophrenia and 1,016 healthy volunteers from the Han population in Northeast China were recruited. The association of three tag single nucleotide polymorphisms (SNPs) (rs2070011 in the 5'UTR, rs2070016 in intron 4, and rs2070022 in the 3'UTR) in FGA and schizophrenia was examined using a case-control study design...
2017: Disease Markers
https://www.readbyqxmd.com/read/28194042/does-mmp-9-gene-polymorphism-play-a-role-in-pituitary-adenoma-development
#17
Brigita Glebauskiene, Rasa Liutkeviciene, Alvita Vilkeviciute, Loresa Kriauciuniene, Silvija Jakstiene, Egle Zlatkute, Abdonas Tamosiunas, Reda Zemaitiene, Paulina Vaitkiene, Dalia Zaliuniene
Purpose. To determine if the MMP-9 genotype has an influence on development of pituitary adenoma (PA). Methodology. The study enrolled n = 86 patients with PA and n = 526 healthy controls (reference group). The genotyping of MMP-9 was carried out using the real-time polymerase chain reaction method. Results. Our data demonstrated that the MMP-9 (-1562) C/C genotype was more frequent in PA group than in healthy controls (81.4% versus 64.6%, p = 0.002); C/C genotype was more frequently present in PA females compared to healthy control females, 81...
2017: Disease Markers
https://www.readbyqxmd.com/read/28182133/he4-serum-levels-in-patients-with-brca1-gene-mutation-undergoing-prophylactic-surgery-as-well-as-in-other-benign-and-malignant-gynecological-diseases
#18
Anita Chudecka-Głaz, Aneta Cymbaluk-Płoska, Aleksandra Strojna, Janusz Menkiszak
Objective. We assess the behavior of serum concentrations of HE4 marker in female carriers of BRCA1 and assess the diagnostic usefulness of HE4 in ovarian and endometrial cancer. Methods. A total of 619 women with BRCA1 gene mutation, ovarian, endometrial, metastatic, other gynecological cancers, or benign gynecological diseases were included. Intergroup comparative analyses were carried out, the BRCA1 gene carriers subgroup was subjected to detailed analysis, and ROC curves were determined for the assessment of diagnostic usefulness of HE4 in ovarian and endometrial cancer...
2017: Disease Markers
https://www.readbyqxmd.com/read/28167849/crosstalk-between-vitamins-a-b12-d-k-c-and-e-status-and-arterial-stiffness
#19
REVIEW
Ioana Mozos, Dana Stoian, Constantin Tudor Luca
Arterial stiffness is associated with cardiovascular risk, morbidity, and mortality. The present paper reviews the main vitamins related to arterial stiffness and enabling destiffening, their mechanisms of action, providing a brief description of the latest studies in the area, and their implications for primary cardiovascular prevention, clinical practice, and therapy. Despite inconsistent evidence for destiffening induced by vitamin supplementation in several randomized clinical trials, positive results were obtained in specific populations...
2017: Disease Markers
https://www.readbyqxmd.com/read/28167848/amniotic-fluid-infection-in-preterm-pregnancies-with-intact-membranes
#20
Tarja Myntti, Leena Rahkonen, Irmeli Nupponen, Anu Pätäri-Sampo, Minna Tikkanen, Timo Sorsa, Juuso Juhila, Sture Andersson, Jorma Paavonen, Vedran Stefanovic
Introduction. Intra-amniotic infection (IAI) is a major cause of preterm labor and adverse neonatal outcome. We evaluated amniotic fluid (AF) proteolytic cascade forming biomarkers in relation to microbial invasion of the amniotic cavity (MIAC) and IAI in preterm pregnancies with intact membranes. Material and Methods. Amniocentesis was made to 73 women with singleton pregnancies; 27 with suspected IAI; and 46 controls. AF biomarkers were divided into three cascades: Cascade 1: matrix metalloproteinase-8 (MMP-8), MMP-9, myeloperoxidase (MPO), and interleukin-6; Cascade 2: neutrophil elastase (HNE), elafin, and MMP-9; Cascade 3: MMP-2, tissue inhibitor of matrix metalloproteinases-1 (TIMP-1), MMP-8/TIMP-1 molar ratio, and C-reactive protein (CRP)...
2017: Disease Markers
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