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Disease Markers

Elsa Saldaña-Rivera, Marissa Jaqueline Careaga-Castilla, Giovani Daniel Olvera-Cárdenas, Elvia Pérez-Soto, Virginia Sánchez-Monroy
Genetic factors, such as the mitochondrial DNA (mtDNA) T16189C polymorphism, have been associated with metabolic syndrome (MetS), but this association has not been studied in Mexico to date. The aim of the present study was to determine whether this polymorphism contributes to MetS in the Mexican population. We recruited 100 unrelated volunteer subjects who were divided into 2 groups: with MetS (MetS group) and without MetS (control group). All subjects were genotyped for the mtDNA T16189C polymorphism by polymerase chain reaction and sequencing...
2018: Disease Markers
Patrizia Cardelli, Mina Hur, Salvatore Di Somma
No abstract text is available yet for this article.
2018: Disease Markers
Meng Zhang, Qianjun Liang, Ligang Zhang, Zongyao Hao, Jun Zhou, Li Zhang, Song Fan, Chaozhao Liang
Objective: We conducted an update meta-analysis aiming to verify the association between p27 -V109G polymorphism and cancer risk, particular for prostate cancer (PCa). Then, we conducted a case-control study of Han Chinese in central China to verify the evidence-based results. Methods: Relevant studies were collected from diverse databases up to March 2017. In addition, a hospital-based (H-B) case-control study enrolling 90 PCa patients and 140 healthy controls was included to verify these evidence-based findings...
2018: Disease Markers
Xiaochun Xia, Chao He, Anqing Wu, Jundong Zhou, Jinchang Wu
Microtubule-associated protein 4 (MAP4) plays an important role in microtubule assembly and stabilization. The purpose of this study was to investigate the level of expression of MAP4 in lung adenocarcinoma (LADC) samples and to evaluate its prognostic value and the influence on cancer progression in LADC patients. The expression of MAP4 protein was analyzed using immunohistochemistry. The clinical significance and the prognostic significance of MAP4 expression were assessed by Kaplan-Meier analysis and Cox regression analysis...
2018: Disease Markers
Yun Gao, Tianpeng Zheng, Xingwu Ran, Yan Ren, Tao Chen, Li Zhong, Donge Yan, Fangfang Yan, Qianlin Wu, Haoming Tian
Aim: To examine whether the baseline 25-hydroxyvitamin D [25(OH)D] level was predictive of the onset of prediabetes or type 2 diabetes (T2DM) in the Chinese population. Methods: This was a 4-year follow-up study that was conducted in the Chengdu region of China as part of the China National Diabetes and Metabolic Disorders Study. The study included 490 participants that were free of prediabetes and type 2 diabetes mellitus (T2DM) at baseline and had complete data by follow-up examinations...
2018: Disease Markers
Natacha Turck, Simone Eperon, Maria De Los Angeles Gracia, Aurélie Obéric, Mehrad Hamédani
Background: Thyroid-associated orbitopathy (TAO) is the most common autoimmune disease of the orbit. It occurs more often in patients presenting with hyperthyroidism, characteristic of Graves' disease, but may be associated with hypothyroidism or euthyroidism. The diagnosis of TAO is based on clinical orbital features, radiological criteria, and the potential association with thyroid disease. To date, there is no specific marker of the orbital disease, making the early diagnosis difficult, especially if the orbital involvement precedes the thyroid dysfunction...
2018: Disease Markers
Dongdong Yu, Yikai Cai, Wei Zhou, Jinghao Sheng, Zhengping Xu
Background: Angiogenin (ANG) is a multifunctional angiogenic protein that participates in both normal development and diseases. Abnormal serum ANG levels are commonly reported in various diseases. However, whether ANG can serve as a diagnostic or prognostic marker for different diseases remains a matter of debate. Methods: Here, we performed a systematic review and meta-analysis of the literature utilizing PubMed, Web of Science, and Scopus search engines to identify all publications comparing plasma or serum ANG levels between patients with different diseases and healthy controls, as were studies evaluating circulating ANG levels in healthy populations, pregnant women, or other demographic populations...
2018: Disease Markers
Yosuke Fujii, Masato Yashiro, Mutsuko Yamada, Tomonobu Kikkawa, Nobuyuki Nosaka, Yukie Saito, Kohei Tsukahara, Masanori Ikeda, Tsuneo Morishima, Hirokazu Tsukahara
Procalcitonin (PCT) is used as a biomarker in severe infections. Here, we retrospectively investigated levels of serum PCT, C-reactive protein (CRP), and inflammatory cytokines (IL-6, TNF- α , and IFN- γ ) in the second phase of patients with acute encephalopathy with biphasic seizures and late reduced diffusion (AESD). Nine AESD pediatric patients (4 men, 5 women; AESD group) admitted to Okayama University Hospital from 2010 to 2016 were compared with 10 control patients with febrile seizures (FS) (3 men, 7 women; FS group)...
2018: Disease Markers
Henning Reis, Ulrich Krafft, Christian Niedworok, Orsolya Módos, Thomas Herold, Mark Behrendt, Hikmat Al-Ahmadie, Boris Hadaschik, Peter Nyirady, Tibor Szarvas
Urachal cancer (UrC) is a rare but aggressive cancer. Due to overlapping histomorphology, discrimination of urachal from primary bladder adenocarcinomas (PBAC) and adenocarcinomas secondarily involving the bladder (particularly colorectal adenocarcinomas, CRC) can be challenging. Therefore, we aimed to give an overview of helpful (immunohistochemical) biomarkers and clinicopathological factors in addition to survival analyses and included institutional data from 12 urachal adenocarcinomas. A PubMed search yielded 319 suitable studies since 1930 in the English literature with 1984 cases of UrC including 1834 adenocarcinomas (92%) and 150 nonadenocarcinomas (8%)...
2018: Disease Markers
Pijun Yan, Yong Xu, Qin Wan, Jian Feng, Hua Li, Jun Yang, Haihua Zhong, Zhihong Zhang
Neuregulin 4 (Nrg4) has been proposed to play a role in the pathogeneses of obesity, insulin resistance, and dyslipidemia. However, information about the link between Nrg4 and metabolic syndrome (MetS) is scarce, especially in patients with newly diagnosed type 2 diabetes mellitus (nT2DM). This study aimed at investigating whether Nrg4 is associated with MetS in nT2DM patients. A total of 311 patients with nT2DM were recruited. Plasma Nrg4 concentration was determined by ELISA. Plasma Nrg4 concentration was lower in nT2DM patients with MetS than in nT2DM patients without MetS ( P = 0...
2018: Disease Markers
Agata Salska, Michał Dziuba, Witold Salski, Krzysztof Chizynski, Marzenna Zielinska
Apelin is a novel peptide of wide expression and multiple biological functions including the crucial role in cardiovascular homeostasis. The apelin role in the pathophysiology of heart rhythm disorders is considered, although the reports are scarce so far. The purpose of this study is to investigate the potential utility of apelin as a marker of arrhythmia recurrence after direct-current cardioversion (DC). The prospective, observational study included 60 patients (aged 41-86; 30% female) with nonvalvular, persistent atrial fibrillation from the group of 204 consecutive patients scheduled for DC during the 12-month period (from May 2010 to May 2011) in the Cardiology Clinic Medical University of Lodz, Poland...
2018: Disease Markers
P Bayrak Degirmenci, S Aksun, Z Altin, F Bilgir, I B Arslan, H Colak, B Ural, D Solakoglu Kahraman, G Diniz, B Ozdemir, C Kırmaz
Background: We aimed in our study to research the role of new cytokines such as IL-35, IL-22, and IL-17 that may form a target for novel treatment approaches. Methods: IL-10, IL-17, TGF- β , IFN- γ , IL-22, and IL-35 serum levels of allergic rhinitis (AR) patients were measured using ELISA method. Allergic sensitization was demonstrated by the skin prick test. Patients only with olive tree sensitivity were evaluated for seasonal AR (SAR). Patients only with mite sensitivity were included in the study for perennial AR (PAR)...
2018: Disease Markers
Yu Chen, Yu Lu, Pilidong Kuyaxi, Jing Cheng, Juan Zhao, Qi Zhao, Patiguli Musha, Hua Zhang, Huijun Yuan
We aim to identify the mutations of deafness genes using massively parallel DNA sequencing in the 12 Uyghur families. SNPscan method was used to screen against the 124 sites in the common deafness genes in probands. Subjects with SNPscan negativity were subject to massively parallel DNA sequencing for the sequencing of 97 genes known to be responsible for hearing loss. Eight families (66.7%) showed biallelic mutations in probands, including MYO15A mutation ( 6892C>T in J02 family, 9514C>T/7894G>T in J07 family, and 9514C>T in J16 family), MYO7A mutation ( 1258A>T in J03 family), TMC1 mutation ( 773G>A in J09 family and 1247T>G/1312G>A in J11 family), and PCDH15 mutation ( 4658delT in J08 and J13 families)...
2018: Disease Markers
Junjeong Choi, Eun-Sol Kim, Ja Seung Koo
Purpose: The purpose of this study was to assess the expression of pentose phosphate pathway- (PPP-) related proteins and their significance in clinicopathologic factors of breast cancer. Methods: Immunohistochemical staining for PPP-related proteins (glucose-6-phosphate dehydrogenase [G6PDH], 6-phosphogluconolactonase [6PGL], 6-phosphogluconate dehydrogenase [6PGDH], and nuclear factor-erythroid 2-related factor 2 [NRF2]) was performed using tissue microarray (TMA) of 348 breast cancers...
2018: Disease Markers
Nice Bedini, Alessandro Cicchetti, Federica Palorini, Tiziana Magnani, Valentina Zuco, Marzia Pennati, Elisa Campi, Paola Allavena, Samantha Pesce, Sergio Villa, Barbara Avuzzi, Sara Morlino, Maria Emanuela Visentin, Nadia Zaffaroni, Tiziana Rancati, Riccardo Valdagni
A recent "hot topic" in prostate cancer radiotherapy is the observed association between acute/late rectal toxicity and the presence of abdominal surgery before radiotherapy. The exact mechanism is unclear. Our working hypothesis was that a previous surgery may influence plasma level of inflammatory molecules and this might result in enhanced radiosensitivity. We here present results on the feasibility of monitoring the expression of inflammatory molecules during radiotherapy. Plasma levels of a panel of soluble mediators associated with the inflammatory response were measured in prostate cancer patients undergoing radical radiotherapy...
2018: Disease Markers
Ekaterina V Martynova, Adelya N Maksudova, Venera G Shakirova, Sayar R Abdulkhakov, Ilsiyar M Khaertynova, Vladimir A Anokhin, Vilena V Ivanova, Ilesanmi M Abiola, Ekaterina E Garanina, Leisan G Tazetdinova, Aigul H Valiullina, Svetlana F Khaiboullina
Kidney insufficiency is a hallmark of nephropathia epidemica (NE). Little is known about the mechanisms of the NE kidney pathology, with current knowledge mainly based on findings in postmortem tissue. We have analyzed kidney damage biomarkers in urine collected from early- and late-phase NE using Bio-Plex kidney toxicity panels 1 and 2. To determine the disease specificity, kidney damage biomarkers were also analyzed in urine samples from patients diagnosed with gout, type 2 diabetes, systemic lupus erythematosus, and chronic kidney insufficiency...
2018: Disease Markers
Mircea Tampa, Constantin Caruntu, Madalina Mitran, Cristina Mitran, Isabela Sarbu, Laura-Cristina Rusu, Clara Matei, Carolina Constantin, Monica Neagu, Simona-Roxana Georgescu
Oral lichen planus (OLP) is a chronic inflammatory disease of unknown etiology with significant impact on patients' quality of life. Malignant transformation into oral squamous cell carcinoma (OSCC) is considered as one of the most serious complications of the disease; nevertheless, controversy still persists. Various factors seem to be involved in the progression of malignant transformation; however, the mechanism of this process is not fully understood yet. Molecular alterations detected in OLP samples might represent useful biomarkers for predicting and monitoring the malignant progression...
2018: Disease Markers
Pawel Sadlecki, Dariusz Grzanka, Marek Grabiec
The Idylla NRAS Mutation Test , performed on the Biocartis Idylla system, is an in vitro diagnostic tool for the qualitative assessment of 18 NRAS mutations in codons 12, 13, 59, 61, 117, and 146. Low-grade serous ovarian cancer (LGSC) represents less than 10% of all serous ovarian carcinomas. LGSCs are believed to arise from preexisting cystadenomas or serous borderline tumors (SBOTs) that eventually progress to an invasive carcinoma. The molecular analysis of cancer-causing mutations and the development of targeted biological therapies constitute a milestone in the diagnosis and therapy of ovarian malignancies...
2018: Disease Markers
Young Rok Ham, Chang Hun Song, Hong Jin Bae, Jin Young Jeong, Min-Kyung Yeo, Dae Eun Choi, Ki-Ryang Na, Kang Wook Lee
Idiopathic membranous nephropathy (IMN) is a major cause of nephrotic syndrome. No biomarker to predict the long-term prognosis of IMN is currently available. Growth differentiation factor-15 (GDF-15) is a member of the transforming growth factor- β superfamily and has been associated with chronic inflammatory disease. It has the potential to be a useful prognostic marker in patients with renal diseases, such as diabetic nephropathy and IgA nephropathy. This study examined whether GDF-15 is associated with the clinical parameters in IMN and showed that GDF-15 can predict IMN disease progression...
2018: Disease Markers
Yuen Yee Cheng, Hong Chuan Jin, Michael W Y Chan, Wai Kit Chu, Michael Grusch
No abstract text is available yet for this article.
2018: Disease Markers
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