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Disease Markers

Maurizio Callari, Paolo Gandellini, Ira Skvortsova, Paul N Span
No abstract text is available yet for this article.
2018: Disease Markers
Tereza Pavlova, Filip Zlamal, Josef Tomandl, Zuzana Hodicka, Sumeet Gulati, Julie Bienertova-Vasku
Irisin, an adipomyokine identified in 2012, has been investigated in association with common pregnancy complications, including gestational diabetes mellitus, preeclampsia, and intrauterine growth restriction. The objective of this study is to examine the potential role of irisin in preterm birth (PTB) by comparing its level between mothers with term and preterm labor. Maternal peripheral blood and cord blood samples were collected from 30 mothers who delivered prematurely and from 35 mothers who delivered at term...
2018: Disease Markers
Juan Castro, Luis Sanchez, María Teresa Nuñez, Ming Lu, Tomas Castro, Hamid R Sharifi, Christer Ericsson
Cancer is known to spread up to 12 years before clinical symptoms occur, but few screening tests exist. Early detection would give the opportunity for early treatment, potentially improving prognosis. To this end, 3388 subjectively healthy individuals of age 45 to 80 who had been exposed to cancer risk factors were screened for the occurrence of circulating tumor cells in their blood. Presence of circulating tumor cells is a suspicious finding indicative of spreading cancer, since cancer metastasizes by way of the blood and offers the opportunities to (a) follow up the individual clinically based on established guidelines for early detection of cancer and (b) evaluate the cells further analytically...
2018: Disease Markers
Christoph Spiekermann, Johannes Roth, Thomas Vogl, Markus Stenner, Claudia Rudack
Peritonsillar inflammation is a common characteristic of both peritonsillar abscess (PTA) and peritonsillitis (PC). The aim of the present study was to apply the PTA score as an objective criterion to identify patients with peritonsillar inflammation (PI) who might profit from medical treatment. Hence, the recently developed PTA score was applied retrospectively on patients suffering from acute tonsillitis, peritonsillitis, and peritonsillar abscess. Analysis of the clinical data, the follow-up, and the initial PTA score was performed...
2018: Disease Markers
Alicja Derkacz, Pawel Olczyk, Katarzyna Komosinska-Vassev
The nonspecific inflammatory bowel diseases (IBD) represent a heterogeneous group of chronic inflammatory disorders of the gastrointestinal tract, and Leśniowski-Crohn's disease (CD) and ulcerative colitis (UC) are among the two major clinical forms. Despite the great progress in understanding the pathogenesis of these diseases, their etiology remains unclear. Genetic, immune, and environmental factors are thought to play a key role. The correct diagnosis of nonspecific inflammatory bowel diseases as well as the determination of disease activity, risk stratification, and prediction of response to therapy still relies on a multidisciplinary approach based on clinical, laboratory, endoscopic, and histologic examination...
2018: Disease Markers
Mostafa Alavi-Moghaddam, Mohammad Chehrazi, Shamila D Alipoor, Maryam Mohammadi, Alireza Baratloo, Mohammad Parsa Mahjoub, Mehrnaz Movasaghi, Johan Garssen, Ian M Adcock, Esmaeil Mortaz
Introduction: miRNAs contribute to a variety of essential biological processes including development, proliferation, differentiation, and apoptosis. Circulating microRNAs are very stable and have shown potential as biomarkers of cardiovascular disease. microRNA-208b expression was increased in the blood of patients with acute myocardial infarction (AMI) and has been proposed as a biomarker for early diagnosis. In this pilot study, we investigate the potential of circulating miR-208b as a prognostic biomarker of 6-month survival in AMI patients...
2018: Disease Markers
Xiao Sun, Xiaobin Zhou, Yuan Zhang, Xiaoyan Zhu, Haihua Liu
Background: It is reported that miRNAs are aberrantly expressed in patients with pancreatic cancer. However, the diagnostic value of miRNAs in pancreatic cancer remains controversial. The meta-analysis was to access diagnostic accuracy of miRNAs in pancreatic cancer. Methods: PubMed, Scopus, Web of Science, Chinese National Knowledge Infrastructure (CNKI), WANFANG Data, China Biomedical Literature Database (CBM), and VIP databases were retrieved up to June 30, 2016, to collect articles concerning the diagnosis of miRNAs in pancreatic cancer...
2018: Disease Markers
Guanzhang Li, Zhiliang Wang, Chuanbao Zhang, Xing Liu, Fuqiang Yang, Lihua Sun, Jingshan Liang, Huimin Hu, Yanwei Liu, Gan You, Zhaoshi Bao, Wei Zhang, Zheng Wang, Tao Jiang
Glioma is the most common primary brain tumor with various genetic alterations; among which, IDH mutation is the most common mutation and plays an important role in glioma early development, especially in lower grade glioma (LGG, WHO II-III). Previous studies have found that IDH mutation is tightly associated with extensive methylation across whole genome in glioma. To further investigate the role of IDH, we obtained methylation data of 777 samples from CGGA (Chinese Glioma Genome Atlas) and TCGA (The Cancer Genome Atlas) with IDH mutation status available...
2018: Disease Markers
Thibaut Pranal, Bruno Pereira, Pauline Berthelin, Laurence Roszyk, Thomas Godet, Russell Chabanne, Nathanael Eisenmann, Alexandre Lautrette, Corinne Belville, Raiko Blondonnet, Sophie Cayot, Thierry Gillart, Yvan Skrzypczak, Bertrand Souweine, Damien Bouvier, Loic Blanchon, Vincent Sapin, Jean-Michel Constantin, Matthieu Jabaudon
Rationale: Although soluble forms of the receptor for advanced glycation end products (RAGE) have been recently proposed as biomarkers in multiple acute or chronic diseases, few studies evaluated the influence of usual clinical and biological parameters, or of patient characteristics and comorbidities, on circulating levels of soluble RAGE in the intensive care unit (ICU) setting. Objectives: To determine, among clinical and biological parameters that are usually recorded upon ICU admission, which variables, if any, could be associated with plasma levels of soluble RAGE...
2018: Disease Markers
Suzana Bojic, Jelena Kotur-Stevuljevic, Aleksandra Aleksic, Jasna Gacic, Lidija Memon, Sanja Simic-Ogrizovic
Background: The role of matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) in sepsis after major abdominal surgery and sepsis-associated organ dysfunction is unexplored. Materials and Methods: Fifty-three patients with sepsis after major abdominal surgery were compared to 50 operated and 50 nonoperated controls. MMP-9, TIMP-1, biomarkers of inflammation, kidney and liver injury, coagulation, and metabolic disorders were measured daily during 96 h following diagnosis of sepsis and once in controls...
2018: Disease Markers
Xuan Li, Danian Dai, Bo Chen, Hailin Tang, Xiaoming Xie, Weidong Wei
Purpose: The prognostic role of serum cancer antigen 15-3 (CA15-3) and carcinoembryonic antigen (CEA) in breast cancer remains controversial. In this study, we conducted a meta-analysis to investigate the prognostic value of these two markers in breast cancer patients. Methods: After electronic databases were searched, 36 studies (31 including information regarding CA15-3 and 23 including information regarding CEA) with 12,993 subjects were included. Based on the data directly or indirectly from the available studies, the hazard ratios (HRs) and odds ratios (ORs) and their 95% confidence intervals (CIs) were pooled according to higher or lower marker levels...
2018: Disease Markers
Iulia Solomon, Vlad Mihai Voiculescu, Constantin Caruntu, Mihai Lupu, Alexandra Popa, Mihaela Adriana Ilie, Radu Albulescu, Ana Caruntu, Cristiana Tanase, Carolina Constantin, Monica Neagu, Daniel Boda
Head and neck squamous cell carcinoma (HNSCC) is one of the most aggressive malignancies. Therefore, the major goal of cancer treatment is inhibition of tumor cell growth and of metastasis development. In order to choose the best management option for HNSCC patients, we need to identify reliable prognostic factors and to develop new molecular techniques in order to obtain a better understanding of therapy resistance. By acting as neurohormones, neurotransmitters, or neuromodulators, the neuroendocrine factors are able to signal the maintenance of physiological homeostasis or progression to malignant disease...
2018: Disease Markers
Esther Paredes-Sánchez, José María Montiel-Company, José Enrique Iranzo-Cortés, Teresa Almerich-Torres, Carlos Bellot-Arcís, José Manuel Almerich-Silla
The objective was to collect the available evidence on oxidative stress marker measurements in periodontal patients, focusing specifically on 8-hydroxy-2'-deoxyguanosine (8-OHdG) as a salivary marker of periodontal disease, and to perform meta-analyses to calculate differences in concentration compared to healthy persons. A systematic search in PubMed, Cochrane Library, Embase, and Scopus identified 81 articles. Of these, 38 were duplicates. After reading the abstracts of the remaining 43, 42 were selected for full-text assessment...
2018: Disease Markers
Vilde Solbakken, Anne-Siri Fismen, Leif Bostad, Rune Bjørneklett
Background: End-stage renal disease (ESRD) risk in patients with antineutrophil cytoplasmic antibody- (ANCA-) associated glomerulonephritis (ANCA-GN) according to ANCA serotype and stratified by histological classification has not been previously investigated. Methods: Patients from the Norwegian Kidney Biopsy Registry (NKBR) between 1991 and 2012 who had biopsy-verified pauci-immune glomerulonephritis and positive antineutrophil cytoplasmic antibody serology were included...
2018: Disease Markers
Liying He, Hongli Wang, Yuhua Zhang, Lanlan Geng, Min Yang, Zhaohui Xu, Kejian Zou, Wanfu Xu, Sitang Gong
Background: Monocarboxylate transporter 4 (MCT4), encoded by SLC16A3 gene, is responsible for exporting lactic acid into the extracellular microenvironment, and an acidic microenvironment promotes cytokine production and remodels chronic inflammation, providing a link from glycolysis to inflammatory bowel disease (IBD). Objective: The aim of this study is to explore the value of MCT4 as a potential biomarker in IBD. Methods: The study group consisted of 39 cases with UC and 15 cases with CD...
2018: Disease Markers
Jorge Luiz Barillo, Cyro Teixeira da Silva Junior, Patricia Siqueira Silva, Joeber Bernardo Soares de Souza, Salim Kanaan, Analucia Rampazzo Xavier, Elizabeth Giestal de Araujo
Adenosine deaminase (ADA) and cytokeratin 19 (CK19) are known pleural biomarkers. Although ADA in humans functions mainly in the immune system, it also appears to be associated with the differentiation of epithelial cells. Keratin filaments are important structural stabilizers of epithelial cells and potent biomarkers in epithelial differentiation. This study aimed to investigate the simultaneous presence of the ADA enzyme and CK19 fragments to assess epithelial differentiation in malignant and benign pleural fluids...
2018: Disease Markers
Seung Ji Kang, Uh Jin Kim, Seong Eun Kim, Joon Hwan An, Mi Ok Jang, Dae-Seong Myung, Kyung-Hwa Park, Sook-In Jung, Sung Bum Cho, Hee-Chang Jang, Young Eun Joo
This prospective observational study aimed at investigating the role of procalcitonin (PCT) in diagnosing bacterial infection and guiding antibiotic therapy for hepatocellular carcinoma (HCC) patients with fever after transarterial chemoembolization (TACE) and/or radiofrequency ablation (RFA). Ninety-seven cases (84 patients) were enrolled. Serum PCT, C-reactive protein (CRP), and white blood cell (WBC) counts were measured on the day of fever onset (day 0) and days 1, 3, 5, and 7 of fever. Empirical antibiotics were initiated only if PCT was ≥0...
2018: Disease Markers
Jin-Song Zhao, Hui-Xiang Jin, Jia-Lin Gao, Chun Pu, Peng Zhang, Jian-Jun Huang, Long Cheng, Gang Feng
Extracellular superoxide dismutase (ecSOD) is the major extracellular scavenger of reactive oxygen species and associated with the diabetic complication in patients with type 2 diabetes mellitus (T2DM). We aimed to investigate the serum ecSOD activity in Chinese patients with different stages of diabetic retinopathy (DR) and evaluate the association between the serum ecSOD activity and the severity of DR. A total of 343 T2DM patients were categorized into three groups: nondiabetic retinopathy (NDR) group, nonproliferative diabetic retinopathy (NPDR) group, and proliferative diabetic retinopathy (PDR) group...
2018: Disease Markers
Zhuoling An, Chao Li, Yali Lv, Pengfei Li, Cheng Wu, Lihong Liu
Metabolic pathway disturbances associated with drug-induced liver injury remain unsatisfactorily characterized. Diagnostic biomarkers for hepatotoxicity have been used to minimize drug-induced liver injury and to increase the clinical safety. A metabolomics strategy using rapid-resolution liquid chromatography/tandem mass spectrometry (RRLC-MS/MS) analyses and multivariate statistics was implemented to identify potential biomarkers for hydrazine-induced hepatotoxicity. The global serum and urine metabolomics of 30 hydrazine-treated rats at 24 or 48 h postdosing and 24 healthy rats were characterized by a metabolomics approach...
2018: Disease Markers
Guanglu Che, Yanyun Wang, Bin Zhou, Linbo Gao, Tao Wang, Fang Yuan, Lin Zhang
Preeclampsia is a pregnancy-related disease with increasing maternal and perinatal morbidity and mortality worldwide. Defective trophoblast invasion is considered to be a major factor in the pathophysiological mechanism of preeclampsia. Heparanase, the only endo- β -glucuronidase in mammalian cells, has been shown to be abnormally expressed in the placenta of preeclampsia patients in our previous study. The biological role and potential mechanism of heparanase in trophoblasts remain unclear. In the present study, stably transfected HTR8/SVneo cell lines with heparanase overexpression or knockdown were constructed...
2018: Disease Markers
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