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Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]

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https://www.readbyqxmd.com/read/28229172/external-beam-radiation-therapy-combined-with-limb-sparing-surgery-in-elderly-patients-70%C3%A2-years-with-primary-soft-tissue-sarcomas-of-the-extremities-a%C3%A2-retrospective-analysis
#1
Claudia Andrä, Alexander Klein, Hans Roland Dürr, Josefine Rauch, Lars Hartwin Lindner, Thomas Knoesel, Martin Angele, Andrea Baur-Melnyk, Claus Belka, Falk Roeder
PURPOSE: To report our experience with EBRT combined with limb-sparing surgery in elderly patients (>70 years) with primary extremity soft tissue sarcomas (STS). METHODS: Retrospectively analyzed were 35 patients (m:f 18:17, median 78 years) who all presented in primary situation without nodal/distant metastases (Charlson score 0/1 in 18 patients; ≥2 in 17 patients). Median tumor size was 10 cm, mainly located in lower limb (83%). Stage at presentation (UICC7th) was Ib:3%, 2a:20%, 2b:20%, and 3:57%...
February 22, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28220185/small-bowel-protection-in-imrt-for-rectal-cancer-a%C3%A2-dosimetric-study-on-supine-vs-prone-position
#2
Julia Koeck, Katharina Kromer, Frank Lohr, Tobias Baack, Kerstin Siebenlist, Sabine Mai, Sylvia Büttner, Jens Fleckenstein, Frederik Wenz
BACKGROUND: This treatment planning study analyzes dose coverage and dose to organs at risk (OAR) in intensity-modulated radiotherapy (IMRT) of rectal cancer and compares prone vs. supine positioning as well as the effect of dose optimization for the small bowel (SB) by additional dose constraints in the inverse planning process. PATIENTS AND METHODS: Based on the CT datasets of ten male patients in both prone and supine position, a total of four different IMRT plans were created for each patient...
February 20, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28197655/prefraction-displacement-and-intrafraction-drift-of-the-prostate-due%C3%A2-to-perineal-ultrasound-probe-pressure
#3
Minglun Li, Nina-Sophie Hegemann, Farkhad Manapov, Anne Kolberg, Patrick Dominik Thum, Ute Ganswindt, Claus Belka, Hendrik Ballhausen
OBJECTIVE: In image-guided EBRT of the prostate, transperineal ultrasound (US) probes exert pressure on the perineum both during planning and treatment. Through tissue deformation and relaxation, this causes target and risk organ displacement and drift. In this study, prefraction shift and intrafraction drift of the prostate are quantified during robotic transperineal 4DUS. METHODS: The position of the prostate was recorded for different positions of the probe before treatment in 10 patients (16 series of measurements)...
February 14, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28197654/temozolomide-during-radiotherapy-of-glioblastoma-multiforme-daily-administration-improves-survival
#4
Silke Birgit Nachbichler, Gabi Schupp, Hendrik Ballhausen, Maximilian Niyazi, Claus Belka
BACKGROUND: Temozolomide-(TMZ)-based chemoradiotherapy defines the current gold standard for the treatment of newly diagnosed glioblastoma. Data regarding the influence of TMZ dose density during chemoradiotherapy are currently not available. We retrospectively compared outcomes in patients receiving no TMZ, TMZ during radiotherapy on radiotherapy days only, and TMZ constantly 7 days a week. PATIENTS AND METHODS: From 2002-2012, a total of 432 patients with newly diagnosed glioblastoma received radiotherapy in our department: 118 patients had radiotherapy alone, 210 had chemoradiotherapy with TMZ (75 mg/m(2)) daily (7/7), and 104 with TMZ only on radiotherapy days (5/7)...
February 14, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28197653/does-selective-pleural-irradiation-of-malignant-pleural-mesothelioma-allow-radiation-dose-escalation-a-planning-study
#5
A Botticella, G Defraene, K Nackaerts, C Deroose, J Coolen, P Nafteux, B Vanstraelen, S Joosten, L A W Michiels, S Peeters, D De Ruysscher
BACKGROUND: After lung-sparing radiotherapy for malignant pleural mesothelioma (MPM), local failure at sites of previous gross disease represents the dominant form of failure. Our aim is to investigate if selective irradiation of the gross pleural disease only can allow dose escalation. MATERIALS AND METHODS: In all, 12 consecutive stage I-IV MPM patients (6 left-sided and 6 right-sided) were retrospectively identified and included. A magnetic resonance imaging-based pleural gross tumor volume (GTV) was contoured...
February 14, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28168322/radical-hypo-fractionated-radiotherapy-with-volumetric-modulated-arc-therapy-in-lung-cancer-a-retrospective-study-of-elderly-patients-with-stage%C3%A2-iii-disease
#6
D Franceschini, F De Rose, L Cozzi, P Navarria, E Clerici, C Franzese, T Comito, A Tozzi, C Iftode, G D'Agostino, M Sorsetti
BACKGROUND: This study aimed to analyse the feasibility and acute toxicity of radical hypo-fractionated radiotherapy (RT) for elderly patients with non-small-cell lung cancer (NSCLC). PATIENTS AND METHODS: We conducted a retrospective evaluation of treatment with volumetric modulated arc therapy (VMAT) of elderly patients affected by stage III inoperable NSCLC. The dose prescription was 56 Gy in 20 fractions, 55 Gy in 22 fractions, or 50 Gy in 20 fractions...
February 6, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28154882/transperineal-gold-marker-implantation-for-image-guided-external-beam-radiotherapy-of-prostate-cancer-a-single-institution-prospective-study
#7
Kliton Jorgo, Péter Ágoston, Tibor Major, Zoltán Takácsi-Nagy, Csaba Polgár
PURPOSE: To present the feasibility and complications of transperineal fiducial marker implantation in prostate cancer patients undergoing image-guided radiotherapy (IGRT) METHODS AND MATERIALS: Between November 2011 and April 2016, three radiopaque, gold-plated markers were transperineally implanted into the prostate of 300 patients under transrectal ultrasound guidance and with local anaesthesia. A week after the procedure patients filled in a questionnaire regarding pain, dysuria, urinary frequency, nocturia, rectal bleeding, hematuria, hematospermia or fever symptoms caused by the implantation...
February 2, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28150021/-substantial-advantage-of-ct-planned-hdr-brachytherapy-for-cervical-cancer-patients-compared-to-a-historical-series-with-regard-to-local-control-and-toxicity
#8
Simone Marnitz
No abstract text is available yet for this article.
February 1, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28144684/combined-p16-and-p53-expression-in-cervical-cancer-of-unknown-primary-and-other-prognostic-parameters-a-single-center-analysis
#9
Müjdat Yildirim, Jens Müller von der Grün, Ria Winkelmann, Emmanouil Fokas, Franz Rödel, Hanns Ackermann, Claus Rödel, Panagiotis Balermpas
BACKGROUND AND PURPOSE: Cervical cancer of unknown primary (CUP) represents an uncommon and heterogeneous subentity of head and neck cancer. However, both optimal diagnostics and therapy remain unclear. An improved understanding of the underlying pathology is essential to enable future tailored therapies and optimized outcomes. MATERIALS AND METHODS: We retrospectively analyzed 53 patients with head and neck CUP and 48 available cervical lymph node specimens. All patients have received radiotherapy between 2007 and 2015...
January 31, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28138949/stereotactic-body-radiotherapy-sbrt-in-recurrent-or-oligometastatic-pancreatic-cancer-a%C3%A2-toxicity-review-of-simultaneous-integrated-protection-sip-versus-conventional-sbrt
#10
E Gkika, S Adebahr, S Kirste, T Schimek-Jasch, R Wiehle, R Claus, U Wittel, U Nestle, D Baltas, A L Grosu, T B Brunner
BACKGROUND: Stereotactic body radiotherapy (SBRT) in pancreatic cancer can be limited by its proximity to organs at risk (OAR). In this analysis, we evaluated the toxicity and efficacy of two different treatment approaches in patients with locally recurrent or oligometastatic pancreatic cancer. MATERIALS AND METHODS: According to the prescription method, patients were divided in two cohorts (C1 and C2). The planning target volume (PTV) was created through a 4 mm expansion of the internal target volume...
January 30, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28130601/complementary-and-alternative-medicine-in-radiation-oncology-survey-of-patients-attitudes
#11
Sabrina Lettner, Kerstin A Kessel, Stephanie E Combs
BACKGROUND: Complementary and alternative medicine (CAM) are gaining in importance, but objective data are mostly missing. However, in previous trials, methods such as acupuncture showed significant advantages compared to standard therapies. Thus, the aim was to evaluate most frequently used methods, their significance and the general acceptance amongst cancer patients undergoing radiotherapy (RT). METHODS: A questionnaire of 18 questions based on the categorical classification released by the National Centre for Complementary and Integrative Health was developed...
January 27, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28124093/neoadjuvant-radiotherapy-followed-by-mastectomy-and-immediate-breast-reconstruction-an-alternative-treatment-option-for-locally-advanced-breast-cancer
#12
Montserrat Pazos, Stefanie Corradini, Darius Dian, Vera von Bodungen, Nina Ditsch, Rachel Wuerstlein, Stephan Schönecker, Nadia Harbeck, Heike Scheithauer, Claus Belka
BACKGROUND: The optimal sequence of mastectomy with immediate breast reconstruction (IBR) and radiotherapy (RT) for the treatment of locally advanced breast cancer (LABC) is still under debate. Increased rates of postoperative complications are described following postmastectomy RT. Neoadjuvant RT aims to improve the aesthetic results and simplify the reconstructive pathway. PATIENTS: A total of 22 patients diagnosed with LABC and treated with neoadjuvant RT followed by mastectomy and IBR between 04/2012 and 03/2015 were retrospectively analyzed...
January 25, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28120007/-influence-of-dose-and-fractionation-in-radiation-therapy-of-curative-intent-for-non-small-cell-lung-cancer
#13
Carsten Nieder
No abstract text is available yet for this article.
January 24, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28120006/-overweight-and-obesity-are-risk-factors-for-development-of-cardiotoxicity-from-anthracyclines-or-sequential-administration-of-anthracyclines-and-trastuzumab
#14
Martin Wilhelm
No abstract text is available yet for this article.
January 24, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28116446/dart-bid-for-loco-regionally-advanced-nsclc-summary-of-acute-and-late-toxicity-with-long-term-follow-up-experiences-with-pulmonary-dose-constraints
#15
Karl Wurstbauer, Franz Zehentmayr, Heinz Deutschmann, Karin Dagn, Ann-Katrin Exeli, Peter Kopp, Peter Porsch, Birgit Maurer, Michael Studnicka, Felix Sedlmayer
BACKGROUND: To report acute and late toxicity with long-term follow-up, and to describe our experiences with pulmonary dose constraints. METHODS: Between 2002 and 2009, 150 patients with 155 histologically/cytologically proven non-small cell lung cancer (NSCLC; tumor stages II, IIIA, IIIB in 6, 55 and 39%, respectively) received the following median doses: primary tumors 79.2 Gy (range 72.0-90.0 Gy), lymph node metastases 59.4 Gy (54.0-73.8 Gy), nodes electively 45 Gy; with fractional doses of 1...
January 23, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28101585/whole-pelvis-radiotherapy-for-pathological-node-positive-prostate-cancer-oncological-outcome-and-prognostic-factors
#16
Filip Poelaert, Valérie Fonteyne, Piet Ost, Bart De Troyer, Karel Decaestecker, Gert De Meerleer, Pieter De Visschere, Tom Claeys, Bert Dhondt, Nicolaas Lumen
PURPOSE: The goal of this work was to investigate the oncological outcome of whole pelvis radiotherapy (wpRT) in pathologic pelvic lymph node-positive (pN1) prostate cancer (PCa), evaluate the location of relapse, and identify potential prognostic factors. PATIENTS AND METHODS: All patients undergoing pelvic lymph node dissection (PLND) since the year 2000 at a single tertiary care center were evaluated. A total of 154 patients with pN1 PCa were treated with wpRT (39 in an adjuvant setting) and 2-3 years of androgen deprivation therapy (ADT)...
January 18, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28044202/cosmetic-changes-following-surgery-and-accelerated-partial-breast-irradiation-using-hdr-interstitial-brachytherapy-evaluation-by-a%C3%A2-multidisciplinary-multigender-committee
#17
Tamer Soror, György Kovács, Nina Seibold, Corinna Melchert, Kristin Baumann, Eike Wenzel, Suzana Stojanovic-Rundic
BACKGROUND: Patients with early-stage breast cancer can benefit from adjuvant accelerated partial breast irradiation (APBI) following breast-conserving surgery (BCS). This work reports on cosmetic results following APBI using multicatheter high-dose-rate interstitial brachytherapy (HDR-IBT). PATIENTS AND METHODS: Between 2006 and 2014, 114 patients received adjuvant APBI using multicatheter HDR-IBT. For each patient, two photographs were analyzed: the first was taken after surgery (baseline image) and the second at the last follow-up visit...
January 2, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28044201/radiotherapy-in-desmoid-tumors-treatment-response-local-control-and-analysis-of-local-failures
#18
Kirsi Santti, Annette Beule, Laura Tuomikoski, Mikko Rönty, Anna-Stina Jääskeläinen, Kauko Saarilahti, Hanna Ihalainen, Maija Tarkkanen, Carl Blomqvist
BACKGROUND: Desmoid tumors (aggressive fibromatosis) are rare soft tissue tumors which frequently recur after surgery. Desmoid tumors arise from musculoaponeurotic tissue in the extremities, head and neck, abdominal wall, or intra-abdominally. Our aim was to examine the outcome of radiotherapy of desmoid tumors in a single institution series. PATIENTS AND METHODS: We evaluated 41 patients with desmoid tumors treated with 49 radiotherapies between 1987 and 2012...
January 2, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28044200/role-of-postoperative-radiotherapy-in-the-management-of-malignant-pleural-mesothelioma-a%C3%A2-propensity-score-matching-of-the-seer-database
#19
Omar Abdel-Rahman
INTRODUCTION: This study assessed the prognostic impact of postoperative radiotherapy in patients with surgically resected malignant pleural mesothelioma (MPM). METHODS: MPM patients diagnosed between 2000 and 2013 were identified from the SEER (Surveillance, Epidemiology, and End Results) database. A propensity-matched analysis was performed considering baseline characteristics (age, gender, race, histology, TNM stage, and type of surgery). RESULTS: A total of 2166 patients were identified...
January 2, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/27957589/radiotherapy-for-aneurysmal-bone-cysts-a%C3%A2-rare-indication
#20
Khaled Elsayad, Jan Kriz, Heinrich Seegenschmiedt, Detlef Imhoff, Reinhard Heyd, Hans Theodor Eich, Oliver Micke
BACKGROUND: Aneurysmal bone cysts (ABC) are rapidly growing benign osseous lesions composed of blood-filled channels separated by fibrous septa. Since the value of external beam radiotherapy (EBRT) for ABC has not been well defined, the German Cooperative Group on Radiotherapy for Benign Diseases performed the national register study described herein. PATIENTS AND METHODS: Five German institutions collected data regarding clinical features, treatment concepts, and outcome for patients with ABC who had been referred for local EBRT over the past 30 years...
December 12, 2016: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
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