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Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]

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https://www.readbyqxmd.com/read/30413833/combined-stereotactic-body-radiotherapy-and-trans-arterial-chemoembolization-as-initial-treatment-in-bclc-stage-b-c-hepatocellular-carcinoma
#1
C L Chiang, Mark K H Chan, Cynthia S Y Yeung, Connie H M Ho, Francis A S Lee, Venus W Y Lee, Frank C S Wong, Oliver Blanck
PURPOSE: We retrospectively evaluated the efficacy and safety of stereotactic body radiotherapy (SBRT) combined with trans-arterial chemoembolization (TACE) as initial therapy in Barcelona Clinic Liver Cancer (BCLC) system stage B-C hepatocellular carcinoma (HCC). PATIENTS AND METHODS: Seventy-two patients received a single dose of TACE followed by SBRT 4 weeks later. All patients had tumor sizes ≥5 cm, at least 700 ml of disease-free liver, Child-Pugh (CP) score ≤ B7 and tumor nodules ≤5...
November 9, 2018: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/30411241/-adjuvant-chemotherapy-with-cisplatin-and-gemcitabine-after-radiochemotherapy-with-curative-intent-does-not-improve-relapse-free-survival-in-nasopharyngeal-cancer-patients-with-persistently-detectable-ebv-dna
#2
Christoph Willich, Thomas B Brunner
No abstract text is available yet for this article.
November 8, 2018: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/30406290/assessment-of-a-guideline-based-heart-substructures-delineation-in-left-sided-breast-cancer-patients-undergoing-adjuvant-radiotherapy-quality-assessment-within-a-randomized-phase-iii-trial-testing-a-cardioprotective-treatment-strategy-safe-2014
#3
Giulio Francolini, Isacco Desideri, Icro Meattini, Carlotta Becherini, Francesca Terziani, Emanuela Olmetto, Camilla Delli Paoli, Donato Pezzulla, Mauro Loi, Pierluigi Bonomo, Daniela Greto, Silvia Calusi, Marta Casati, Stefania Pallotta, Lorenzo Livi
BACKGROUND AND PURPOSE: In our institute, breast cancer patients undergoing adjuvant treatment are included in a protocol aimed to reduce cardiovascular morbidity (SAFE-2014, NCT2236806), assessing preclinical heart damage with heart speckle-tracking ultrasound. To develop a dose constraint related to subclinical heart damage, a reliable delineation of heart substructures based on a pre-existing guideline was made. PATIENTS AND METHODS: Heart substructures of 16 left-sided breast cancer patients included in the SAFE protocol were delineated by five operators...
November 7, 2018: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/30406289/patient-versus-physician-reported-outcomes-in-prostate-cancer-patients-receiving-hypofractionated-radiotherapy-within-a-randomized-controlled-trial
#4
Elke Rammant, Piet Ost, Martijn Swimberghe, Barbara Vanderstraeten, Nicolaas Lumen, Karel Decaestecker, Renée Bultijnck, Gert De Meerleer, Camille Sarrazyn, Roos Colman, Valérie Fonteyne
PURPOSE: The risk of developing acute radiotherapy(RT)-induced side effects may increase with hypofractionated RT. To detect treatment-related side effects, patient-reported outcomes (PROs) might be more reliable than physician-reported outcomes. Therefore, we tried to evaluate the rate of agreement between urinary and gastrointestinal (GI) side effects and the prevalence of side effects reported by patients and by physicians. METHODS: Data from a randomized controlled trial (RCT) comparing two hypofractionated RT schedules were used...
November 7, 2018: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/30390115/toxicity-and-risk-factors-after-combined-high-dose-rate-brachytherapy-and-external-beam-radiation-therapy-in-men-%C3%A2-75-years-with-localized-prostate-cancer
#5
Anastassia Löser, Burkhard Beyer, Cedric Oliver Carl, Benjamin Löser, Yamini Nagaraj, Thorsten Frenzel, Cordula Petersen, Andreas Krüll, Markus Graefen, Rudolf Schwarz
PURPOSE: Combined high-dose-rate brachytherapy (HDR-BT) and external beam radiation therapy (EBRT) is a favorable treatment option in non-metastatic prostate cancer. However, reports on toxicity and outcome have mainly focused on younger patients. We aimed to determine toxicity and biochemical control rates after combined HDR-BT and EBRT in men ≥75 years. METHODS: From 1999 to 2015, 134 patients aged ≥75 years (median 76 years; 75-82 years) were identified...
November 2, 2018: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/30390114/chemoradiotherapy-with-and-without-deep-regional-hyperthermia-for-squamous-cell-carcinoma-of-the-anus
#6
Oliver J Ott, Manfred Schmidt, Sabine Semrau, Vratislav Strnad, Klaus E Matzel, Ignaz Schneider, Dimitrios Raptis, Wolfgang Uter, Robert Grützmann, Rainer Fietkau
PURPOSE: To compare results after chemoradiotherapy with and without deep regional hyperthermia in patients with anal cancer. METHODS: Between 2000 and 2015, a total of 112 consecutive patients with UICC stage I-IV anal cancer received chemoradiotherapy with 5‑fluororuracil and mitomycin C (CRT). In case of insufficient tumor response 4-6 weeks after chemoradiotherapy, patients received an interstitial pulsed-dose-rate brachytherapy boost. Additionally, 50/112 patients received hyperthermia treatments (HCRT)...
November 2, 2018: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/30386864/cavity-volume-changes-after-surgery-of-a-brain-metastasis-consequences-for-stereotactic-radiation-therapy
#7
Sophia Scharl, Anna Kirstein, Kerstin A Kessel, Marciana-Nona Duma, Markus Oechsner, Christoph Straube, Stephanie E Combs
PURPOSE: For a large or symptomatic brain metastasis, resection and adjuvant radiotherapy are recommended. Hypofractionated stereotactic radiotherapy (HFSRT) is increasingly applied in patients with a limited number of lesions. Exact target volume definition is critical given the small safety margins. Whilst technical advances have minimized inaccuracy due to patient positioning and radiation targeting, little is known about changes in target volume. This study sought to evaluate potential changes in the resection cavity of a brain metastasis...
November 1, 2018: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/30377698/is-low-dose-radiotherapy-an-effective-treatment-for-baker-s-cyst
#8
Matthias G Hautmann, Ernst-Michael Jung, Lukas P Beyer, Christoph Süß, Felix Steger, Markus Weber, Fabian Pohl, Oliver Kölbl, Franz Josef Putz
PURPOSE: Osteoarthritis of the knee is a common disease, often associated with a Baker's cyst. Besides osteoarthritis, also other joint pathologies of the knee can be causative for a Baker's cyst. Radiotherapy is known to be an effective treatment for osteoarthritis, with an anti-inflammatory effect. As the excessive production of synovia usually is associated with intraarticular inflammation, our hypothesis was that radiotherapy might positively influence the synovial production and reduce the volume of a Baker's cyst...
October 30, 2018: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/30374592/-combination-immunotherapy-for-patients-with-brain-metastases-of-malignant-melanoma-de-escalation-only-under-controlled-conditions-with-frequent-imaging
#9
Carsten Nieder
No abstract text is available yet for this article.
October 29, 2018: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/30374591/-adjuvant-radiotherapy-in-the-multimodal-treatment-of-resectable-gastric-cancer-criticism-of-the-conclusions-drawn-from-critics
#10
Robert Michael Hermann, Hans Christiansen
No abstract text is available yet for this article.
October 29, 2018: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/30374590/fractionated-stereotactic-radiation-therapy-for-adrenal-metastases-contributing-to-local-tumor-control-with-low-toxicity
#11
Kim Burjakow, Rainer Fietkau, Florian Putz, Nils Achterberg, Sebastian Lettmaier, Stefan Knippen
PURPOSE: To report on the Erlangen (UK-Er) experience with linear accelerator stereotactic body radiation therapy (LINAC SBRT) for adrenal metastasis from various primary tumors. MATERIALS AND METHODS: 33 patients were treated. Primary sites included lung (n = 19), melanoma (n = 8), colorectal (n = 2), hepatocellular (n = 1), esophageal (n = 2), and breast cancer (n = 1). 14 patients were treated palliatively, 19 patients were treated with local curative intent...
October 29, 2018: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/30361744/comparison-of-treatment-plans-for-a-high-field-mri-linac-and-a-conventional-linac-for-esophageal-cancer
#12
Marcel Nachbar, David Mönnich, Paul Kalwa, Daniel Zips, Daniela Thorwarth, Cihan Gani
PURPOSE: To compare radiotherapy treatments plans in esophageal cancer calculated for a high-field magnetic resonance imaging (MRI)-linac with plans for a conventional linac. MATERIALS AND METHODS: Ten patients with esophageal squamous cell carcinomas were re-planned retrospectively using the research version of Monaco (V 5.19.03, Elekta AB, Stockholm, Sweden). Intensity modulated radiotherapy (IMRT) plans with a nine-field step-and-shoot technique and two-arc volumetric modulated arc therapy (VMAT) plans were created for the Elekta MRI-linac and a conventional linac, respectively...
October 25, 2018: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/30353350/repeated-sbrt-for-in-and-out-of-field-recurrences-in-the-liver
#13
Eleni Gkika, Iosif Strouthos, Simon Kirste, Sonja Adebahr, Michael Schultheiss, Dominik Bettinger, Ralph Fritsch, Volker Brass, Lars Maruschke, Hannes Philipp Neeff, Sven Arke Lang, Ursula Nestle, Anca-Ligia Grosu, Thomas Baptist Brunner
PURPOSE: To evaluate the feasibility and toxicity profile of repeated stereotactic body radiotherapy (SBRT) for recurrent primary or secondary liver tumors. METHODS: Consecutive patients with primary (hepatocellular carcinoma [HCC] or cholangiocarcinoma [CCC]) or secondary liver cancer (LM), with intrahepatic recurrence or progression after SBRT, underwent re-SBRT in 3 to 12 fractions with a median time of 15 (range 2-66) months between treatments. RESULTS: In all, 24 patients which were previously treated with SBRT (30 lesions) were retreated with SBRT for "in- and out-of-field" recurrences (2nd SBRT: n = 28, 3rd SBRT: n = 2)...
October 23, 2018: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/30353349/sbrt-planning-for-spinal-metastasis-indications-from-a-large-multicentric-study
#14
Marco Esposito, Laura Masi, Margherita Zani, Raffaela Doro, David Fedele, Cristina Garibaldi, Stefania Clemente, Christian Fiandra, Francesca Romana Giglioli, Carmelo Marino, Laura Orsingher, Serenella Russo, Michele Stasi, Lidia Strigari, Elena Villaggi, Pietro Mancosu
BACKGROUND: The dosimetric variability in spine stereotactic body radiation therapy (SBRT) planning was investigated in a large number of centres to identify crowd knowledge-based solutions. METHODS: Two spinal cases were planned by 48 planners (38 centres). The required prescription dose (PD) was 3 × 10 Gy and the planning target volume (PTV) coverage request was: VPD  > 90% (minimum request: VPD  > 80%). The dose constraints were: planning risk volume (PRV) spinal cord: V18Gy  < 0...
October 23, 2018: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/30350118/exposure-of-remote-organs-and-associated-cancer-risks-from-tangential-and-multi-field-breast-cancer-radiotherapy
#15
C Simonetto, H Rennau, J Remmele, S Sebb, P Kundrát, M Eidemüller, U Wolf, G Hildebrandt
PURPOSE: With the ever-increasing cure rates in breast cancer, radiotherapy-induced cancers have become an important issue. This study aimed to estimate secondary cancer risks for different treatment techniques, taking into account organs throughout the body. MATERIAL AND METHODS: Organ doses were evaluated for a tangential three-dimensional conformal (3D-CRT) and a multi-field intensity-modulated radiotherapy (IMRT) plan using a validated, Monte Carlo-based treatment planning system...
October 22, 2018: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/30334066/dosimetric-and-volumetric-effects-in-clinical-target-volume-and-organs-at-risk-during-postprostatectomy-radiotherapy
#16
Ahmed Gawish, Ahmed Ali Chughtai, Michael J Eble
PURPOSE: To assess the reproducibility of the dose-volume distribution of the initial simulation CT, generated using volumetric modulated arc therapy (VMAT) planning, during the radiotherapy of the prostatic bed based on weekly cone beam CTs (CBCT). METHODS: Twenty-three patients, after radical prostatectomy were treated with adjuvant or salvage radiotherapy between July and December 2016 and considered for this evaluation. Weekly CBCT scans (n = 138) were imported into the treatment planning system, and the clinical tumor volume (CTV), the rectum and the bladder were contoured...
October 17, 2018: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/30324290/long-term-endothelial-dysfunction-in-irradiated-vessels-an-immunohistochemical-analysis
#17
Raimund H M Preidl, Patrick Möbius, Manuel Weber, Kerstin Amann, Friedrich W Neukam, Marco Kesting, Carol-Immanuel Geppert, Falk Wehrhan
BACKGROUND: Microvascular free flap reconstruction has become a standard technique in head and neck reconstructive surgery. Pre-operative radiotherapy is associated with a higher incidence of free flap malperfusion and the need for operative revision. Irradiated vessels present characteristic histomorphological and structural changes. Alterations in endothelial cells of irradiated arteries remain incompletely investigated especially with regard to long-term changes in endothelial dysfunction supporting an intraluminal pro-thrombotic and pro-inflammatory milieu...
October 15, 2018: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/30315483/penile-bulb-sparing-in-prostate-cancer-radiotherapy-dose-analysis-of-an-in-house-mri-system-to-improve-contouring
#18
F Böckelmann, M Hammon, S Lettmaier, R Fietkau, C Bert, F Putz
OBJECTIVE: This study aimed to assess the reduction in dose to the penile bulb (PB) achieved by MRI-based contouring following drinking and endorectal balloon (ERB) instructions. PATIENTS AND METHODS: A total of 17 prostate cancer patients were treated with intensity-modulated radiation therapy (IMRT) and interstitial brachytherapy (IBT). CT and MRI datasets were acquired back-to-back based on a 65 cm3 air-filled ERB and drinking instructions. After rigid co-registration of the imaging data, the CT-based planning target volume (PTV) used for treatment planning was retrospectively compared to an MRI-based adaptive PTV and the dose to the PB was determined in each case...
October 12, 2018: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/30310926/heart-toxicity-from-breast-cancer-radiotherapy-current-findings-assessment-and-prevention
#19
REVIEW
Marc D Piroth, René Baumann, Wilfried Budach, Jürgen Dunst, Petra Feyer, Rainer Fietkau, Wulf Haase, Wolfgang Harms, Thomas Hehr, David Krug, Arnd Röser, Felix Sedlmayer, Rainer Souchon, Frederik Wenz, Rolf Sauer
BACKGROUND: Late cardiac toxicities caused by (particularly left-sided) breast radiotherapy (RT) are now recognized as rare but relevant sequelae, which has prompted research on risk structure identification and definition of threshold doses to heart subvolumes. The aim of the present review was to critically discuss the clinical evidence on late cardiac reactions based on dose-dependent outcome reports for mean heart doses as well as doses to cardiac substructures. METHODS: A literature review was performed to examine clinical evidence on radiation-induced heart toxicities...
October 11, 2018: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/30302507/a-density-assignment-method-for-dose-monitoring-in-head-and-neck-radiotherapy
#20
A Barateau, N Perichon, J Castelli, U Schick, O Henry, E Chajon, A Simon, C Lafond, R De Crevoisier
BACKGROUND AND PURPOSE: During head-and-neck (H&N) radiotherapy, the parotid glands (PGs) may be overdosed; thus, a tool is required to monitor the delivered dose. This study aimed to assess the dose accuracy of a patient-specific density assignment method (DAM) for dose calculation to monitor the dose to PGs during treatment. PATIENTS AND METHODS: Forty patients with H&N cancer received an intensity modulated radiation therapy (IMRT), among whom 15 had weekly CTs...
October 9, 2018: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
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