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Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]

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https://www.readbyqxmd.com/read/28540428/erratum-to-combined-p16-and-p53-expression-in-cervical-cancer-of-unknown-primary-and-other-prognostic-parameters
#1
Müjdat Yildirim, Jens Müller von der Grün, Ria Winkelmann, Emmanouil Fokas, Franz Rödel, Hanns Ackermann, Claus Rödel, Panagiotis Balermpas
No abstract text is available yet for this article.
May 24, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28526916/-salvage-radiotherapy-with-antiandrogen-therapy-after-prostatectomy-significant-overall-survival-benefit-compared-to-radiotherapy-alone
#2
Gregor Goldner
No abstract text is available yet for this article.
May 19, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28523338/-how-long-should-we-wait-upon-completion-of-chemoradiotherapy-before-assessment-of-tumor-response-in-anal-cancer
#3
Daniel Martin, Claus Rödel, Emmanouil Fokas
No abstract text is available yet for this article.
May 18, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28516198/-local-consolidative-therapy-improves-progression-free-survival-in-patients-with-oligometastatic-nsclc-results-of-a-randomized-phase%C3%A2-ii-study
#4
Tobias Finazzi, Matthias Guckenberger
No abstract text is available yet for this article.
May 17, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28500491/hyperfractionated-accelerated-radiation-therapy-plus-cetuximab-plus-cisplatin-chemotherapy-in-locally-advanced-inoperable-squamous-cell-carcinoma-of-the-head-and-neck-final-5%C3%A2-year-results-of-a-phase%C3%A2-ii-study
#5
Thomas Kuhnt, Andreas Schreiber, Anett Pirnasch, Matthias G Hautmann, Peter Hass, Frank P Sieker, Rita Engenhart-Cabillic, Michael Richter, Kathrin Dellas, Jürgen Dunst
BACKGROUND: Cetuximab (CET) is a potent inhibitor of the epidermal growth factor receptor and has been shown to have activity in squamous cell carcinoma of the head and neck (SCCHN). We conducted a single-arm phase II trial of a combination therapy comprising cisplatin (CIS), CET and hyperfractionated accelerated radiotherapy (HART). PATIENTS AND METHODS: Patients with UICC stage III or IVA/B, M0 SCCHN were enrolled and treated with an initial dose of CET (400 mg/m(2)) and then with a weekly dosage of 250 mg/m(2) during HART...
May 12, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28500490/effects-of-definitive-and-salvage-radiotherapy-on-the-distribution-of-lymphocyte-subpopulations-in-prostate-cancer-patients
#6
Eva K Sage, Thomas E Schmid, Hans Geinitz, Mathias Gehrmann, Michael Sedelmayr, Marciana N Duma, Stephanie E Combs, Gabriele Multhoff
BACKGROUND: Radiotherapy (RT) is an established treatment for patients with primary and recurrent prostate cancer. Herein, the effects of definitive and salvage RT on the composition of lymphocyte subpopulations were investigated in patients with prostate cancer to study potential immune effects. PATIENTS AND METHODS: A total of 33 prostate cancer patients were treated with definitive (n = 10) or salvage RT (n = 23) after biochemical relapse. The absolute number of lymphocytes and the distribution of lymphocyte subpopulations were analyzed by multiparameter flow cytometry before RT, at the end of RT, and in the follow-up period...
May 12, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28492995/general-health-status-of-long-term-cervical-cancer-survivors-after-radiotherapy
#7
Lee Sung Uk, Kim Young Ae, Yoon Young-Ho, Kim Yeon-Joo, Lim Myong Cheol, Park Sang-Yoon, Seo Sang-Soo, Park Ji Eun, Kim Joo-Young
PURPOSE: To evaluate the global health status of long-term cervical cancer survivors (LCCS) who survived for more than 4 years after curative radiation treatment (RT). PATIENTS AND METHODS: Medical records of 562 women treated with RT in our institution between 2003 and 2010 were reviewed. Excluding 259 women who died of disease or were lost to follow-up, disease status and late morbidities were evaluated in 303 LCCS. Quality of life (QoL) was analyzed in 168 LCCS using a questionnaire from the European Organization for the Research and Treatment of Cancer, and the results were compared with an age-matched healthy Korean female population...
May 10, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28488030/-125-i%C3%A2-brachytherapy-in-younger-prostate-cancer-patients-outcomes-in-low-and-intermediate-risk-disease
#8
Isabelle Kindts, Karin Stellamans, Ignace Billiet, Hans Pottel, Antoon Lambrecht
PURPOSE: To evaluate local recurrence in younger men treated with low-dose-rate (LDR) (125)I brachytherapy (BT) for localized prostate cancer. PATIENTS AND METHODS: A total of 192 patients (≤65-years-old) were treated with LDR (125)I-BT ± hormone therapy. Local failure was defined as any prostate-specific antigen (PSA) rise leading to salvage treatment or biochemical failure according to the Phoenix definition. A bounce was defined as a rise in the nadir of ≥0...
May 9, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28474090/t1-2-glottic-cancer-treated-with-radiotherapy-and-or-surgery
#9
Mohamed Shelan, Lukas Anschuetz, Adrian D Schubert, Beat Bojaxhiu, Alan Dal Pra, Frank Behrensmeier, Daniel M Aebersold, Roland Giger, Olgun Elicin
BACKGROUND: The optimal treatment strategy for stage I-II glottic squamous cell carcinoma (SCC) is not well-defined. This study analyzed treatment results and prognostic factors. PATIENTS AND METHODS: This is a single-institution retrospective analysis of 244 patients with T1-2 glottic SCC who underwent normofractionated radiotherapy (RT) and/or surgery between 1990 and 2013. The primary endpoint was relapse-free survival (RFS). RESULTS: Median age was 65 years (range: 36-92 years), the majority (82%) having stage I disease...
May 4, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28470414/defining-biochemical-recurrence-after-radical-prostatectomy-and-timing-of-early-salvage-radiotherapy-informing-the-debate
#10
Lars Budäus, Jonas Schiffmann, Markus Graefen, Hartwig Huland, Pierre Tennstedt, Alessandra Siegmann, Dirk Böhmer, Volker Budach, Detlef Bartkowiak, Thomas Wiegel
BACKGROUND: The optimal prostate-specific antigen (PSA) level after radical prostatectomy (RP) for defining biochemical recurrence and initiating salvage radiation therapy (SRT) is still debatable. Whereas adjuvant or extremely early SRT irrespective of PSA progression might be overtreatment for some patients, SRT at PSA >0.2 ng/ml might be undertreatment for others. The current study addresses the optimal timing of radiation therapy after RP. PATIENTS AND METHODS: Cohort 1 comprised 293 men with PSA 0...
May 3, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28466155/dosimetric-implications-of-inter-and-intrafractional-prostate-positioning-errors-during-tomotherapy-comparison-of-gold-marker-based-registrations-with-native-mvct
#11
Peter Wust, Marc Joswig, Reinhold Graf, Dirk Böhmer, Marcus Beck, Thomasz Barelkowski, Volker Budach, Pirus Ghadjar
INTRODUCTION: For high-dose radiation therapy (RT) of prostate cancer, image-guided (IGRT) and intensity-modulated RT (IMRT) approaches are standard. Less is known regarding comparisons of different IGRT techniques and the resulting residual errors, as well as regarding their influences on dose distributions. PATIENTS AND METHODS: A total of 58 patients who received tomotherapy-based RT up to 84 Gy for high-risk prostate cancer underwent IGRT based either on daily megavoltage CT (MVCT) alone (n = 43) or the additional use of gold markers (n = 15) under routine conditions...
May 2, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28466154/spinal-cord-constraints-in-the-era-of-high-precision-radiotherapy-retrospective-analysis-of-62%C3%A2-spinal-paraspinal-lesions-with-possible-infringements-of-spinal-cord-constraints-within-a%C3%A2-minimal-volume
#12
Sebastian Zschaeck, Peter Wust, Reinhold Graf, Waldemar Wlodarczyk, Reinhard Schild, Alexander Henry Thieme, Mirko Weihrauch, Volker Budach, Pirus Ghadjar
OBJECTIVE: Current constraints aim to minimize the risk of radiation myelitis by the use of restrictive maximal spinal cord doses, commonly 50 Gy. However, several studies suggested that a dose-volume effect could exist. Based on these observations, we evaluated patients receiving potentially excessive doses to the spinal cord within minimal volumes. PATIENTS AND METHODS: Patients receiving radiotherapy between June 2010 and May 2015 using the Novalis(TM) (Varian, Palo Alto, CA, USA; Brainlab, Heimstetten, Germany) radiosurgery system were retrospectively analyzed...
May 2, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28444430/successful-treatment-of-a%C3%A2-rare-case-of-ameloblastic-fibrosarcoma-with-radiation-therapy
#13
Michael Oertel, Gabriele Reinartz, Sergiu Scobioala, Hans Theodor Eich
Sarcomas are rare diseases of the head and neck region, representing around 1% of all malignancies. Amongst them, ameloblastic fibrosarcoma (AFS) is of even greater rarity, with less than 100 cases reported in the literature. Consequently, no standard treatment or guidelines have been made available. Surgery is often performed as primary therapy, but may be limited due to anatomical or functional reasons. We present a case of AFS successfully treated by postoperative radiation therapy. A detailed case study is provided, followed by a review of the English-language literature focusing on the role of radiation therapy...
April 25, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28444429/hypopharyngeal-and-upper-esophageal-ulceration-after-cervical-spine-radiotherapy-concurrent-with-crizotinib
#14
Marcus H Zimmermann, Gabriele Beckmann, Pius Jung, Michael Flentje
Herein, the authors describe the case of a 31-year-old female patient with primary metastatic adenocarcinoma of the lung referred for radiation therapy of newly diagnosed intramedullary spinal cord metastasis at C4/5 and an adjacent osteolytic lesion. Radiotherapy of the cervical spine level C3 to C5, including the whole vertebra, was performed with 30 Gy in 10 fractions. The patient's systemic therapy with crizotinib 250 mg twice daily was continued. After 8 fractions of radiation the patient developed increasing dysphagia...
April 25, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28424841/dosimetric-predictors-of-radiation-induced-pericardial-effusion-in%C3%A2-esophageal-cancer
#15
Ichiro Ogino, Shigenobu Watanabe, Kentaro Sakamaki, Yuka Ogino, Chikara Kunisaki, Kazuo Kimura
PURPOSE: To evaluate the dose-volume parameters of the pericardium and heart in order to reduce the risk of radiation-induced pericardial effusion (PE) and symptomatic PE (SPE) in esophageal cancer patients treated with concurrent chemoradiotherapy. METHODS: In 86 of 303 esophageal cancer patients, follow-up CT was obtained at least 24 months after concurrent chemoradiotherapy. Correlations between clinical factors, including risk factors for cardiac disease, dosimetric factors, and the incidence of PE and SPE after radiotherapy were analyzed using Cox proportional hazard regression analysis...
April 19, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28424840/reirradiation-for-recurrent-head-and-neck-cancers-using-charged-particle-or-photon-radiotherapy
#16
Hideya Yamazaki, Yusuke Demizu, Tomoaki Okimoto, Mikio Ogita, Kengo Himei, Satoaki Nakamura, Gen Suzuki, Ken Yoshida, Tadayuki Kotsuma, Yasuo Yoshioka, Ryoongjin Oh
OBJECTIVE: To examine the outcomes of reirradiation for recurrent head and neck cancers using different modalities. METHODS: This retrospective study included 26 patients who received charged particle radiotherapy (CP) and 150 who received photon radiotherapy (117 CyberKnife radiotherapy [CK] and 36 intensity-modulated radiotherapy [IMRT]). Inverse probability of treatment weighting (IPTW) involving propensity scores was used to reduce background selection bias...
April 19, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28424839/reirradiation-of-recurrent-node-positive-non-small-cell-lung-cancer-after-previous-stereotactic-radiotherapy-for-stage%C3%A2-i-disease-a%C3%A2-multi-institutional-treatment-recommendation
#17
Carsten Nieder, Dirk De Ruysscher, Laurie E Gaspar, Matthias Guckenberger, Minesh P Mehta, Patrick Cheung, Arjun Sahgal
BACKGROUND: Practice guidelines have been developed for early-stage and locally advanced non-small cell lung cancer (NSCLC). However, many common clinical scenarios still require individualized decision making. This is true for locoregional relapse after initial stereotactic radiotherapy (stereotactic body radiation therapy or stereotactic ablative radiotherapy; SBRT or SABR), an increasingly utilized curative treatment option for stage I NSCLC. METHODS: A consortium of expert radiation oncologists was established with the aim of providing treatment recommendations...
April 19, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28424838/improved-oncologic-outcome-with-chemoradiotherapy-followed-by-surgery-in-unresectable-intrahepatic-cholangiocarcinoma
#18
Yeona Cho, Tae Hyung Kim, Jinsil Seong
PURPOSE: To investigate the ability of chemoradiotherapy (CRT) to down-stage unresectable intrahepatic cholangiocarcinoma (IHCC) to resectable lesions, as well as the factors associated with achieving such down-staging. METHODS: The study cohort comprised 120 patients diagnosed with stage I-IVA IHCC between 2001 and 2012. Of these patients, 56 underwent surgery and 64 received CRT as their initial treatment. The rate of curative resections for patients who received CRT was assessed, and the locoregional failure-free survival (LRFFS) and overall survival (OS) rates of these patients were compared to those of patients who underwent CRT alone...
April 19, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28409249/-combining-radiation-plus-temozolomide-in-glioblastoma-patients-older-than-65-years-of-age
#19
Christoph Straube, Stephanie E Combs
No abstract text is available yet for this article.
April 13, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28409248/-radiotherapy-for-glioblastoma-asco-endorses-the-astro-guideline
#20
Clemens Seidel, Rolf-Dieter Kortmann
No abstract text is available yet for this article.
April 13, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
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