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Glycoconjugate Journal

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https://www.readbyqxmd.com/read/28101734/chondroitin-sulfates-and-their-binding-molecules-in-the-central-nervous-system
#1
REVIEW
L Djerbal, H Lortat-Jacob, Jcf Kwok
Chondroitin sulfate (CS) is the most abundant glycosaminoglycan (GAG) in the central nervous system (CNS) matrix. Its sulfation and epimerization patterns give rise to different forms of CS, which enables it to interact specifically and with a significant affinity with various signalling molecules in the matrix including growth factors, receptors and guidance molecules. These interactions control numerous biological and pathological processes, during development and in adulthood. In this review, we describe the specific interactions of different families of proteins involved in various physiological and cognitive mechanisms with CSs in CNS matrix...
January 18, 2017: Glycoconjugate Journal
https://www.readbyqxmd.com/read/28091942/all-trans-retinoic-acid-supplementation-prevents-cardiac-fibrosis-and-cytokines-induced-by-methylglyoxal
#2
Umadevi Subramanian, Devipriya Nagarajan
Methylglyoxal (MG), a metabolic intermediate of glycolysis is a precursor for endogeneous production of advanced glycation end-products. The increased production of MG have negative influence over the structure and function of different biomolecules and thus plays an important role in the pathogenesis of diabetic cardiac complications. Retinoic acid (RA), an active metabolite of vitamin A, has a major role in preventing cardiac remodeling and ventricular fibrosis. Hence, the objective of the present study was to determine whether rats administered with all-trans retinoic acid (RA) could attenuate MG induced pathological effects...
January 14, 2017: Glycoconjugate Journal
https://www.readbyqxmd.com/read/28091941/occurrence-of-complex-type-free-n-glycans-with-a-single-glcnac-residue-at-the-reducing-termini-in-the-fresh-water-plant-egeria-densa
#3
Megumi Maeda, Natsuki Ebara, Misato Tani, Christopher J Vavricka, Yoshinobu Kimura
In our previous study, we found unique free N-glycans (FNGs), which carry a single GlcNAc residue (GN1) at the reducing-end side and the Lewis-a epitope at the non-reducing-end side, in the culture broth of rice cells. Based on the FNG structural features and the substrate specificity of plant ENGase, we hypothesized that there might be a novel biosynthetic mechanism responsible for the production of these unique GN1-FNGs, in which high-mannose type (HMT)-GN1-FNGs produced in the cytosol from misfolded glycoproteins by ENGase are transported back into the endoplasmic reticulum and processed to plant complex type (PCT)-GN1-FNGs in the Golgi apparatus...
January 14, 2017: Glycoconjugate Journal
https://www.readbyqxmd.com/read/28091940/purification-and-sequence-characterization-of-chondroitin-sulfate-and-dermatan-sulfate-from-fishes
#4
Na Lin, Xiaoli Mo, Yang Yang, Hong Zhang
Chondroitin sulfate (CS) and dermatan sulfate (DS) were extracted and purified from skins or bones of salmon (Salmo salar), snakehead (Channa argus), monkfish (Lophius litulon) and skipjack tuna (Katsuwonus pelamis). Size, structural sequences and sulfate groups of oligosaccharides in the purified CS and DS could be characterized and identified using high performance liquid chromatography (HPLC) combined with Orbitrap mass spectrometry. CS and DS chain structure varies depending on origin, but motif structure appears consistent...
January 14, 2017: Glycoconjugate Journal
https://www.readbyqxmd.com/read/28091939/immuno-pcr-technology-for-detection-of-natural-human-antibodies-against-le-c-disaccharide
#5
Artem V Maerle, Daria V Voronina, Kira L Dobrochaeva, Oxana E Galanina, Leonid P Alekseev, Nicolai V Bovin, Sergei K Zavriev, Dmitriy Yu Ryazantsev
The development of an immuno-PCR assay for quantitation of low amounts of anti-glycan human antibodies is described. The sensitivity of the assay for determination of low-affinity anti-Le(C) IgM has been found to be 4 ng/ml (~100 pg per sample), thus being two orders of magnitude higher compared to the conventional ELISA with the same antigen.
January 14, 2017: Glycoconjugate Journal
https://www.readbyqxmd.com/read/28078490/podocalyxin-as-a-major-pluripotent-marker-and-novel-keratan-sulfate-proteoglycan-in-human-embryonic-and-induced-pluripotent-stem-cells
#6
REVIEW
Hidenao Toyoda, Yuko Nagai, Aya Kojima, Akiko Kinoshita-Toyoda
Podocalyxin (PC) was first identified as a heavily sialylated transmembrane protein of glomerular podocytes. Recent studies suggest that PC is a remarkable glycoconjugate that acts as a universal glyco-carrier. The glycoforms of PC are responsible for multiple functions in normal tissue, human cancer cells, human embryonic stem cells (hESCs), and human induced pluripotent stem cells (hiPSCs). PC is employed as a major pluripotent marker of hESCs and hiPSCs. Among the general antibodies for human PC, TRA-1-60 and TRA-1-81 recognize the keratan sulfate (KS)-related structures...
January 11, 2017: Glycoconjugate Journal
https://www.readbyqxmd.com/read/28035583/specific-n-glycan-alterations-are-coupled-in-emt-induced-by-different-density-cultivation-of-mcf-10a-epithelial-cells
#7
Qingsong Xu, Xueming Niu, Wenjing Wang, Wen Yang, Yuguang Du, Jianguo Gu, Linsheng Song
Epithelial-mesenchymal transition (EMT) is a process in tumor progression during which cancer cells undergo dramatic changes acquiring highly invasive properties. In a widespread adoption of TGF-β-induced EMT model, we have previously observed that expression of bisecting GlcNAc on N-glycans was dramatically decreased. Herein, we performed in vitro studies with the MCF10A cell line. In response to low cell density, MCF10A cells suffered spontaneously morphologic and phenotypic EMT-like changes, including elongated spindle shape, extended out from edge of the cell sheet, cytoskeleton reorganization, vimentin and fibronectin up-regulation, catenins redistribution, and cadherin switching...
December 29, 2016: Glycoconjugate Journal
https://www.readbyqxmd.com/read/28004286/the-2016-tamio-yamakawa-award
#8
Akemi Suzuki, Tamao Endo, Naoyuki Taniguchi
No abstract text is available yet for this article.
December 21, 2016: Glycoconjugate Journal
https://www.readbyqxmd.com/read/27975161/extraction-selenylation-modification-and-antitumor-activity-of-the-glucan-from-castanea-mollissima-blume
#9
Hongyan Li, Yingxing Wang, Chao Wang, Shaohan Zhang, Shenghui Li, Guoqiang Zhou, Shuxiang Wang, Jinchao Zhang
The present study aimed to characterize the glucan from C. mollissima Blume fruits and its selenium derivative, then investigate their antitumor activity in vitro. A glucan, designated as CPA, was firstly isolated from the fruits of C. mollissima Blume. Structure analysis indicated that CPA was a linear 1,6-α-D-glucan with the average molecular weight about 2.0 × 10(3) kDa. The selenylation modification derivative of CPA (sCPA), exhibited a stronger antiproliferative effect on tumor cells than CPA in vitro...
December 14, 2016: Glycoconjugate Journal
https://www.readbyqxmd.com/read/27975160/glycosylation-a-hallmark-of-cancer
#10
REVIEW
Bhairavi N Vajaria, Prabhudas S Patel
The hallmarks of cancer are characterized by functional capabilities that allow cancer cells to survive, proliferate and disseminate during the multistep tumorigenesis. Cancer being a cellular disease, changes in cellular glycoproteins play an important role in malignant transformation and cancer progression. The present review summarizes various studies that depicted correlation of glycosylation with tumor initiation, progression and metastasis, which are helpful in early diagnosis, disease monitoring and prognosis...
December 14, 2016: Glycoconjugate Journal
https://www.readbyqxmd.com/read/27928742/implementation-of-infrared-and-raman-modalities-for-glycosaminoglycan-characterization-in-complex-systems
#11
Hossam Taha Mohamed, Valérie Untereiner, Ganesh D Sockalingum, Stéphane Brézillon
Glycosaminoglycans (GAGs) are natural, linear and negatively charged heteropolysaccharides which are incident in every mammalian tissue. They consist of repeating disaccharide units, which are composed of either sulfated or non-sulfated monosaccharides. Depending on tissue types, GAGs exhibit structural heterogeneity such as the position and degree of sulfation or within their disaccharide units composition being heparin, heparan sulfate, chondroitine sulfate, dermatan sulfate, keratan sulfate, and hyaluronic acid...
December 7, 2016: Glycoconjugate Journal
https://www.readbyqxmd.com/read/27928741/site-specific-glycosylation-of-the-newcastle-disease-virus-haemagglutinin-neuraminidase
#12
Cassandra L Pegg, Christine Hoogland, Jeffrey J Gorman
Members of the Avulavirus, Respirovirus and Rubulavirus genera of the Paramyxoviridae family of viruses utilise haemagglutinin-neuraminidase glycoproteins as their attachment proteins. These glycoproteins are oligomeric type II integral membrane proteins, which possess haemagglutination and sialidase activity. Previous studies have shown that the N-linked glycans present on these proteins can modulate the ability of the virus to infect host cells and stimulate the host immune system. However, site-specific heterogeneity of these glycans has not been defined...
December 7, 2016: Glycoconjugate Journal
https://www.readbyqxmd.com/read/27924424/rgta-%C3%A2-or-regenerating-agents-mimic-heparan-sulfate-in-regenerative-medicine-from-concept-to-curing-patients
#13
REVIEW
Denis Barritault, Marie Gilbert-Sirieix, Kim Lee Rice, Fernando Siñeriz, Dulce Papy-Garcia, Christophe Baudouin, Pascal Desgranges, Gilbert Zakine, Jean-Louis Saffar, Johan van Neck
The importance of extracellular matrix (ECM) integrity in maintaining normal tissue function is highlighted by numerous pathologies and situations of acute and chronic injury associated with dysregulation or destruction of ECM components. Heparan sulfate (HS) is a key component of the ECM, where it fulfils important functions associated with tissue homeostasis. Its degradation following tissue injury disrupts this delicate equilibrium and may impair the wound healing process. ReGeneraTing Agents (RGTA(®)s) are polysaccharides specifically designed to replace degraded HS in injured tissues...
December 7, 2016: Glycoconjugate Journal
https://www.readbyqxmd.com/read/27924423/ms-ir-a-new-ms-based-hyphenated-method-for-analysis-of-hexuronic-acid-epimers-in-glycosaminoglycans
#14
Baptiste Schindler, Gina Renois-Predelus, Nassiba Bagdadi, Sihem Melizi, Loïc Barnes, Stéphane Chambert, Abdul-Rahman Allouche, Isabelle Compagnon
We report an original MS-based hyphenated method for the elucidation of the epimerization in GAG fragments. It consists of measuring simultaneously the MS/MS spectrum and the gas phase IR spectrum to gain direct structural information. This is possible using a customized MS instrument, modified to allow injection of a tunable IR laser inside of the instrument for in situ spectroscopy of trapped ions. The proof of principle of this approach is performed in the case of a hyaluronic acid tetrasaccharide standard...
December 7, 2016: Glycoconjugate Journal
https://www.readbyqxmd.com/read/27900575/glycosaminoglycanomics-where-we-are
#15
Sylvie Ricard-Blum, Frédérique Lisacek
Glycosaminoglycans regulate numerous physiopathological processes such as development, angiogenesis, innate immunity, cancer and neurodegenerative diseases. Cell surface GAGs are involved in cell-cell and cell-matrix interactions, cell adhesion and signaling, and host-pathogen interactions. GAGs contribute to the assembly of the extracellular matrix and heparan sulfate chains are able to sequester growth factors in the ECM. Their biological activities are regulated by their interactions with proteins. The structural heterogeneity of GAGs, mostly due to chemical modifications occurring during and after their synthesis, makes the development of analytical techniques for their profiling in cells, tissues, and biological fluids, and of computational tools for mining GAG-protein interaction data very challenging...
November 30, 2016: Glycoconjugate Journal
https://www.readbyqxmd.com/read/27900574/mast-cell-glycosaminoglycans
#16
REVIEW
B Mulloy, R Lever, C P Page
Mast cells contain granules packed with a mixture of proteins that are released on degranulation. The proteoglycan serglycin carries an array of glycosaminoglycan (GAG) side chains, sometimes heparin, sometimes chondroitin or dermatan sulphate. Tight packing of granule proteins is dependent on the presence of serglycin carrying these GAGs. The GAGs of mast cells were most intensively studied in the 1970s and 1980s, and though something is known about the fine structure of chondroitin sulphate and dermatan sulphate in mast cells, little is understood about the composition of the heparin/heparan sulphate chains...
November 30, 2016: Glycoconjugate Journal
https://www.readbyqxmd.com/read/27866299/localization-and-dynamics-of-the-anticarcinogenic-curcumin-with-gm1-and-other-miceller-assemblies
#17
Malay Patra, Manoj Mandal, Abhijit Chakrabarti, Chaitali Mukhopadhyay
Structural transitions involving shape changes play an important role in cellular physiology and enhance the bioavailability of the natural food like curcumin in surfactant aggregates. In this work, we have studied the localization, dynamics and stability of curcumin in various miceller assemblies using a combination of absorbance and fluorescence spectroscopic approaches. The measurements of absorption and fluorescence spectra of curcumin revealed that the nature of interactions of ionic and nonionic surfactants and the glycosphingolipid, GM1 with curcumin is significantly different with surfactant concentrations...
November 19, 2016: Glycoconjugate Journal
https://www.readbyqxmd.com/read/27858203/enhanced-fucosylation-of-ga1-in-the-digestive-tracts-of-x-ray-irradiated-mice
#18
Masao Iwamori, Kyoko Tanaka, Shigeki Adachi, Daisuke Aoki, Taisei Nomura
In mice at 4 days after X-ray-irradiation at 0.5 Gy/min for 16 min, the tissue weights of immune organs, i.e., thymus and spleen, were decreased due to injury to lymphocytes by the X-rays. The resulting immunosuppressive condition allowed the growth of lactobacilli, i.e., L. murinus, which contained LacβTH-DG and possessed the ability to induce transcription of the fucosyltransferase gene for synthesis of FGA1. LacβTH-DG was detected in the jejunal and ileal contents of X-ray-irradiated mice, but not in those of control mice, whereas LacTetH-DG of L...
November 18, 2016: Glycoconjugate Journal
https://www.readbyqxmd.com/read/27858202/computational-drill-down-on-fgf1-heparin-interactions-through-methodological-evaluation
#19
Sándor Babik, Sergey A Samsonov, M Teresa Pisabarro
Glycosaminoglycans (GAGs) exhibit a key role in cellular communication processes through interactions with target proteins of the extracellular matrix (ECM). The sandwich-like interaction established between Fibroblast growth factor (FGF) and heparin (HE) represents quite a peculiar protein-GAG-protein system, which has been both structurally and functionally intensively studied. The molecular recognition characteristics of this system have been exploited in various computational studies in order to deepen understanding of GAG-protein interactions...
November 17, 2016: Glycoconjugate Journal
https://www.readbyqxmd.com/read/27812771/the-in-and-out-of-glucosamine-6-o-sulfation-the-6th-sense-of-heparan-sulfate
#20
REVIEW
Rana El Masri, Amal Seffouh, Hugues Lortat-Jacob, Romain R Vivès
The biological properties of Heparan sulfate (HS) polysaccharides essentially rely on their ability to bind and modulate a multitude of protein ligands. These interactions involve internal oligosaccharide sequences defined by their sulfation patterns. Amongst these, the 6-O-sulfation of HS contributes significantly to the polysaccharide structural diversity and is critically involved in the binding of many proteins. HS 6-O-sulfation is catalyzed by 6-O-sulfotransferases (6OSTs) during biosynthesis, and it is further modified by the post-synthetic action of 6-O-endosulfatases (Sulfs), two enzyme families that remain poorly characterized...
November 3, 2016: Glycoconjugate Journal
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