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Glycoconjugate Journal

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https://www.readbyqxmd.com/read/27900575/glycosaminoglycanomics-where-we-are
#1
Sylvie Ricard-Blum, Frédérique Lisacek
Glycosaminoglycans regulate numerous physiopathological processes such as development, angiogenesis, innate immunity, cancer and neurodegenerative diseases. Cell surface GAGs are involved in cell-cell and cell-matrix interactions, cell adhesion and signaling, and host-pathogen interactions. GAGs contribute to the assembly of the extracellular matrix and heparan sulfate chains are able to sequester growth factors in the ECM. Their biological activities are regulated by their interactions with proteins. The structural heterogeneity of GAGs, mostly due to chemical modifications occurring during and after their synthesis, makes the development of analytical techniques for their profiling in cells, tissues, and biological fluids, and of computational tools for mining GAG-protein interaction data very challenging...
November 30, 2016: Glycoconjugate Journal
https://www.readbyqxmd.com/read/27900574/mast-cell-glycosaminoglycans
#2
REVIEW
B Mulloy, R Lever, C P Page
Mast cells contain granules packed with a mixture of proteins that are released on degranulation. The proteoglycan serglycin carries an array of glycosaminoglycan (GAG) side chains, sometimes heparin, sometimes chondroitin or dermatan sulphate. Tight packing of granule proteins is dependent on the presence of serglycin carrying these GAGs. The GAGs of mast cells were most intensively studied in the 1970s and 1980s, and though something is known about the fine structure of chondroitin sulphate and dermatan sulphate in mast cells, little is understood about the composition of the heparin/heparan sulphate chains...
November 30, 2016: Glycoconjugate Journal
https://www.readbyqxmd.com/read/27900573/erratum-to-molecular-dissection-of-placental-malaria-protein-var2csa-interaction-with-a-chemo-enzymatically-synthesized-chondroitin-sulfate-library
#3
Nobuo Sugiura, Thomas Mandel Clausen, Tatsumasa Shioiri, Tobias Gustavsson, Hideto Watanabe, Ali Salanti
No abstract text is available yet for this article.
November 30, 2016: Glycoconjugate Journal
https://www.readbyqxmd.com/read/27866299/localization-and-dynamics-of-the-anticarcinogenic-curcumin-with-gm1-and-other-miceller-assemblies
#4
Malay Patra, Manoj Mandal, Abhijit Chakrabarti, Chaitali Mukhopadhyay
Structural transitions involving shape changes play an important role in cellular physiology and enhance the bioavailability of the natural food like curcumin in surfactant aggregates. In this work, we have studied the localization, dynamics and stability of curcumin in various miceller assemblies using a combination of absorbance and fluorescence spectroscopic approaches. The measurements of absorption and fluorescence spectra of curcumin revealed that the nature of interactions of ionic and nonionic surfactants and the glycosphingolipid, GM1 with curcumin is significantly different with surfactant concentrations...
November 19, 2016: Glycoconjugate Journal
https://www.readbyqxmd.com/read/27858203/enhanced-fucosylation-of-ga1-in-the-digestive-tracts-of-x-ray-irradiated-mice
#5
Masao Iwamori, Kyoko Tanaka, Shigeki Adachi, Daisuke Aoki, Taisei Nomura
In mice at 4 days after X-ray-irradiation at 0.5 Gy/min for 16 min, the tissue weights of immune organs, i.e., thymus and spleen, were decreased due to injury to lymphocytes by the X-rays. The resulting immunosuppressive condition allowed the growth of lactobacilli, i.e., L. murinus, which contained LacβTH-DG and possessed the ability to induce transcription of the fucosyltransferase gene for synthesis of FGA1. LacβTH-DG was detected in the jejunal and ileal contents of X-ray-irradiated mice, but not in those of control mice, whereas LacTetH-DG of L...
November 18, 2016: Glycoconjugate Journal
https://www.readbyqxmd.com/read/27858202/computational-drill-down-on-fgf1-heparin-interactions-through-methodological-evaluation
#6
Sándor Babik, Sergey A Samsonov, M Teresa Pisabarro
Glycosaminoglycans (GAGs) exhibit a key role in cellular communication processes through interactions with target proteins of the extracellular matrix (ECM). The sandwich-like interaction established between Fibroblast growth factor (FGF) and heparin (HE) represents quite a peculiar protein-GAG-protein system, which has been both structurally and functionally intensively studied. The molecular recognition characteristics of this system have been exploited in various computational studies in order to deepen understanding of GAG-protein interactions...
November 17, 2016: Glycoconjugate Journal
https://www.readbyqxmd.com/read/27812771/the-in-and-out-of-glucosamine-6-o-sulfation-the-6th-sense-of-heparan-sulfate
#7
REVIEW
Rana El Masri, Amal Seffouh, Hugues Lortat-Jacob, Romain R Vivès
The biological properties of Heparan sulfate (HS) polysaccharides essentially rely on their ability to bind and modulate a multitude of protein ligands. These interactions involve internal oligosaccharide sequences defined by their sulfation patterns. Amongst these, the 6-O-sulfation of HS contributes significantly to the polysaccharide structural diversity and is critically involved in the binding of many proteins. HS 6-O-sulfation is catalyzed by 6-O-sulfotransferases (6OSTs) during biosynthesis, and it is further modified by the post-synthetic action of 6-O-endosulfatases (Sulfs), two enzyme families that remain poorly characterized...
November 3, 2016: Glycoconjugate Journal
https://www.readbyqxmd.com/read/27796614/glycans-define-the-stemness-of-na%C3%A3-ve-and-primed-pluripotent-stem-cells
#8
Shoko Nishihara
Cell surface glycans are tissue-specific and developmentally regulated. They function as essential modulators in cell-cell interactions, cell-extracellular matrix interactions, and ligand-receptor interactions, binding to various ligands, including Wnt, fibroblast growth factors, and bone morphogenetic proteins. Embryonic stem (ES) cells, originally derived from the inner cell mass of blastocysts, have the essential characteristics of pluripotency and self-renewal. Recently, it has been proposed that mouse and human conventional ES cells are present in different developmental stages, namely pre-implantation blastocyst and post-implantation blastocyst stages, also called the naïve state and the primed state, respectively...
October 28, 2016: Glycoconjugate Journal
https://www.readbyqxmd.com/read/27796613/catfish-rhamnose-binding-lectin-induces-g0-1-cell-cycle-arrest-in-burkitt-s-lymphoma-cells-via-membrane-surface-gb3
#9
Shigeki Sugawara, Changhun Im, Tasuku Kawano, Takeo Tatsuta, Yasuhiro Koide, Daiki Yamamoto, Yasuhiro Ozeki, Kazuo Nitta, Masahiro Hosono
Silurus asotus egg lectin (SAL), an α-galactoside-binding protein isolated from the eggs of catfish, is a member of the rhamnose-binding lectin family that binds to Gb3 glycan (Galα1-4Galβ1-4Glc). We have previously demonstrated that SAL reduces the proliferation of Gb3-expressing Burkitt's lymphoma Raji cells and confirm here that it does not reduce their viability, indicating that unlike other lectins, it is not cytotoxic. The aim of this study was to determine the signal transduction mechanism(s) underlying this novel SAL/Gb3 binding-mediated effect profile...
October 28, 2016: Glycoconjugate Journal
https://www.readbyqxmd.com/read/27778131/the-role-of-heparins-and-nano-heparins-as-therapeutic-tool-in-breast-cancer
#10
Nikos A Afratis, Konstantina Karamanou, Zoi Piperigkou, Demitrios H Vynios, Achilleas D Theocharis
Glycosaminoglycans are integral part of the dynamic extracellular matrix (ECM) network that control crucial biochemical and biomechanical signals required for tissue morphogenesis, differentiation, homeostasis and cancer development. Breast cancer cells communicate with stromal ones to modulate ECM mainly through release of soluble effectors during cancer progression. The intracellular cross-talk between cell surface receptors and estrogen receptors is important for the regulation of breast cancer cell properties and production of ECM molecules...
October 24, 2016: Glycoconjugate Journal
https://www.readbyqxmd.com/read/27771794/an-integrated-approach-using-orthogonal-analytical-techniques-to-characterize-heparan-sulfate-structure
#11
Daniela Beccati, Miroslaw Lech, Jennifer Ozug, Nur Sibel Gunay, Jing Wang, Elaine Y Sun, Joël R Pradines, Victor Farutin, Zachary Shriver, Ganesh V Kaundinya, Ishan Capila
Heparan sulfate (HS), a glycosaminoglycan present on the surface of cells, has been postulated to have important roles in driving both normal and pathological physiologies. The chemical structure and sulfation pattern (domain structure) of HS is believed to determine its biological function, to vary across tissue types, and to be modified in the context of disease. Characterization of HS requires isolation and purification of cell surface HS as a complex mixture. This process may introduce additional chemical modification of the native residues...
October 22, 2016: Glycoconjugate Journal
https://www.readbyqxmd.com/read/27752801/glycosaminoglycans-from-chicken-muscular-stomach-or-gizzard
#12
Yin Chen, Megan Reddy, Yanlei Yu, Fuming Zhang, Robert J Linhardt
Glycosaminoglycans (GAGs) were prepared from the muscular stomach or gizzard of the chicken. The content of GAGs on a dry weight basis contains 0.4 wt.% a typical value observed for a muscle tissue. The major GAG components were chondroitin-6-sulfate and chondroitin-4-sulfate (~64 %) of molecular weight 21-22 kDa. Hyaluronan (~24 %) had a molecular weight 120 kDa. Smaller amounts (12 %) of heparan sulfate was also present which was made of more highly sulfated chains of molecular weight of 21-22 kDa and a less sulfated low molecular weight (< 10 kDa) heterogeneous partially degraded heparan sulfate...
October 17, 2016: Glycoconjugate Journal
https://www.readbyqxmd.com/read/27744520/mda-mb-231-breast-cancer-cell-viability-motility-and-matrix-adhesion-are-regulated-by-a-complex-interplay-of-heparan-sulfate-chondroitin-dermatan-sulfate-and-hyaluronan-biosynthesis
#13
Manuela Viola, Kathrin Brüggemann, Evgenia Karousou, Ilaria Caon, Elena Caravà, Davide Vigetti, Burkhard Greve, Christian Stock, Giancarlo De Luca, Alberto Passi, Martin Götte
Proteoglycans and glycosaminoglycans modulate numerous cellular processes relevant to tumour progression, including cell proliferation, cell-matrix interactions, cell motility and invasive growth. Among the glycosaminoglycans with a well-documented role in tumour progression are heparan sulphate, chondroitin/dermatan sulphate and hyaluronic acid/hyaluronan. While the mode of biosynthesis differs for sulphated glycosaminoglycans, which are synthesised in the ER and Golgi compartments, and hyaluronan, which is synthesized at the plasma membrane, these polysaccharides partially compete for common substrates...
October 15, 2016: Glycoconjugate Journal
https://www.readbyqxmd.com/read/27738830/emil-fischer-carbohydrate-award-2017
#14
(no author information available yet)
No abstract text is available yet for this article.
October 13, 2016: Glycoconjugate Journal
https://www.readbyqxmd.com/read/27726058/vimentin-is-important-in-the-neural-differentiation-of-pc12-cells-promoted-by-sialylation
#15
Li Hui Wu, Xiao Ting Shao, Jun Xia Guo, Hui Sun, Qi Chen, Jing Pan, Qian Qian Cai, Yi Wei Dong, Zhong Yi Chen, Xiao Mei Yan, Min Peng, Nanbert Zhong, Xing Zhong Wu
Sialic acid modification is a kind of post-translational modification. To investigate the regulation effect of sialic acid on neural differentiation, we used CycloManN propanyl perac (CycloManN pro), a metabolic precursor of sialic acid, to treat PC12 cells. We noted that CycloManN pro indeed robustly promoted global sialylation detected by MAL II lectin blot in PC12 cells. Simultaneously, we interestingly found that the neurite outgrowth of PC12 cells was significantly promoted by the CycloManN pro treatment...
October 10, 2016: Glycoconjugate Journal
https://www.readbyqxmd.com/read/27714477/targeted-site-specific-quantitation-of-n-and-o-glycopeptides-using-18-o-labeling-and-product-ion-based-mass-spectrometry
#16
Jandhyam Srikanth, Rathinasamy Agalyadevi, Ponnusamy Babu
The site-specific quantitation of N- and O-glycosylation is vital to understanding the function(s) of different glycans expressed at a given site of a protein under physiological and disease conditions. Most commonly used precursor ion intensity based quantification method is less accurate and other labeled methods are expensive and require enrichment of glycopeptides. Here, we used glycopeptide product (y and Y0) ions and (18)O-labeling of C-terminal carboxyl group as a strategy to obtain quantitative information about fold-change and relative abundance of most of the glycoforms attached to the glycopeptides...
October 6, 2016: Glycoconjugate Journal
https://www.readbyqxmd.com/read/27709407/sulfated-glycosaminoglycans-their-distinct-roles-in-stem-cell-biology
#17
Tadahisa Mikami, Hiroshi Kitagawa
Sulfated glycosaminoglycan (GAG) chains are a class of long linear polysaccharides that are covalently attached to multiple core proteins to form proteoglycans (PGs). PGs are major pericellular and extracellular matrix components that surround virtually all mammalian cell surfaces, and create conducive microenvironments for a number of essential cellular events, such as cell adhesion, cell proliferation, differentiation, and cell fate decisions. The multifunctional properties of PGs are mostly mediated by their respective GAG moieties, including chondroitin sulfate (CS), heparan sulfate (HS), and keratan sulfate (KS) chains...
October 6, 2016: Glycoconjugate Journal
https://www.readbyqxmd.com/read/27699585/click-inspired-synthesis-of-triazole-linked-vanillin-glycoconjugates
#18
Pratibha Dwivedi, Kunj B Mishra, Pritika, Bhuwan B Mishra, Vinod K Tiwari
The 1,3-dipolar cycloaddition of deoxy-azido sugars 1 with alkyne derivatives of p-vanillin, 3-methoxy-4-(prop-2-ynyloxy)benzaldehyde (2) and 2-methoxy-1-(prop-2-ynyloxy)-4-((prop-2-ynyloxy)methyl)benzene) (4) to afford regioselective triazole-linked vanillinglycoconjugates 5 and 6 was investigated in the presence of CuI/DIPEA in dichloromethane. All the developed glycoconjugates were characterized on the basis of IR, NMR, and MS. Graphical abstract Triazolyl vanillin glycoconjugates via click chemistry.
October 3, 2016: Glycoconjugate Journal
https://www.readbyqxmd.com/read/27658397/internalization-of-a-novel-huge-lectin-from-ibacus-novemdentatus-slipper-lobster-induces-apoptosis-of-mammalian-cancer-cells
#19
Y Fujii, T Fujiwara, Y Koide, I Hasan, S Sugawara, S Rajia, S M A Kawsar, D Yamamoto, D Araki, R A Kanaly, Y Ogawa, H Fujita, Y Ozeki
An N-acetyl sugar-binding lectin (termed iNoL) displaying cytotoxic activity against human cancer cells was isolated from the slipper lobster Ibacus novemdentatus (family Scyllaridae). iNoL recognized monosaccharides containing N-acetyl group, and glycoproteins (e.g., BSM) containing oligosaccharides with N-acetyl sugar. iNoL was composed of five subunits (330, 260, 200, 140, and 30 kDa), which in turn consisted of 70-, 40-, and 30-kDa polypeptides held together by disulfide bonds. Electron microscopic observations and gel permeation chromatography indicated that iNoL was a huge (500-kDa) molecule and had a polygonal structure under physiological conditions...
September 22, 2016: Glycoconjugate Journal
https://www.readbyqxmd.com/read/27645300/structures-and-gene-clusters-of-the-o-specific-polysaccharides-of-the-lipopolysaccharides-of-escherichia-coli-o69-and-o146-containing-glycolactilic-acids-ether-conjugates-of-d-glcnac-and-d-glc-with-r-and-s-lactic-acid
#20
Yuriy A Knirel, Xi Guo, Sof'ya N Senchenkova, Andrei V Perepelov, Bin Liu, Alexander S Shashkov
Based on the O-specific polysaccharides of the lipopolysaccharides (O-polysaccharides, O-antigens), strains of a clonal species Escherichia coli are classified into 184 O serogroups. In this work, structures of the O-polysaccharides of E. coli O69 and O146 were elucidated and gene clusters for their biosynthesis were characterized. The O-polysaccharides were released from the lipopolysaccharides by mild acid hydrolysis and studied by sugar analysis and one- and two-dimensional (1)H and (13)C NMR spectroscopy before and after O-deacetylation...
September 19, 2016: Glycoconjugate Journal
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