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Toxicology and Industrial Health

S Saritha, Chand Basha Davuljigari, K Praveen Kumar, G Rajrami Reddy
In this study, we evaluated the therapeutic efficacy of monoisoamyldimercaptosuccinic acid (MiADMSA) against individual and combined effects of arsenic (As) and lead (Pb) on the monoaminergic system and behavioral functions in rats. Pregnant rats were exposed to sodium metaarsenite (50 ppm) and lead acetate (0.2%) individually and in combination (As = 25 ppm + Pb = 0.1%) via drinking water from gestation day (GD) 6 to postnatal day (PND) 21. MiADMSA (50 mg/kg body weight) was given orally through gavage for 3 consecutive days to pups from PND 18 to PND 20...
December 10, 2018: Toxicology and Industrial Health
Kuder Reshma Shabnam, Dharmapuri Gangappa, Gundala Harold Philip
Evaluation of the toxic effects of a widely used synthetic pyrethroid, deltamethrin (DM), was carried out in this study. This pesticide is preferred for pest control because of its low environmental persistence and toxicity. We investigated the expression pattern of four genes, namely, you ( you), yot ( you-too), momo ( mom) and ubo ( u-boot) during early development of zebrafish, that is, from 12 hpf to 48 hpf stages. These stages are selected as most of the important developmental aspects take place during this period...
December 5, 2018: Toxicology and Industrial Health
Haibo Yang, Jifeng Wang, Xinxin Yang, Fengdi Wu, Zhipeng Qi, Bin Xu, Wei Liu, Yu Deng
It has been found that exposure to manganese (Mn) could induce reproductive dysfunction, but its occupational risk in male workers is unclear. This study aims to assess the association of occupational Mn exposure with reproductive hormones and semen quality in a cross-sectional study. Urinary Mn, semen quality, and reproductive hormones were explored in 84 male workers occupationally exposed to Mn and 92 referents. Multiple linear regression analyses were used to assess the relationship. Urinary Mn levels in Mn-exposed workers ranged from 0...
November 22, 2018: Toxicology and Industrial Health
Jing Liu, Hong-Wei Wang, Wen-Peng Zhao, Xiao-Ting Li, Lin Lin, Bian-Hua Zhou
This study was designed to investigate the effects of excessive fluoride on spleen toxicity. Twenty-four healthy female rats were randomly divided into two groups, each of 12 rats. Each group of female rats was given a control diet and either F- = 0 mg/L or an excessive F- = 150 mg/L in the drinking water for 120 days. The histomorphological and ultrastructural changes in their splenic tissues were observed under light and transmission electron microscopes. DNA damage and splenocyte apoptosis were examined using the micronucleus (MN) assay, single-cell gel electrophoresis (SCGE), and flow cytometry...
November 21, 2018: Toxicology and Industrial Health
Maryam Hormozi, Ramazan Mirzaei, Alireza Nakhaee, Abolfazl Payandeh, Shahrokh Izadi, Javid Dehghan Haghighi
Iranian Registry of Clinical Trials Registration Number: IRCT2016061228407N1 ( ).
November 19, 2018: Toxicology and Industrial Health
Mahak Azadi, Amir Hessam Hasani, Mohammad Ebrahim Olya, Seyed Mehdi Borghei
In the present research, a zinc oxide (ZnO)-silver (Ag)-neodymium (Nd) nanocomposite was synthesized via the combustion method for the degradation of dyes as organic pollutants. The synthesized nanophotocatalyst was characterized using X-ray diffraction, Fourier transform infrared spectroscopy, and scanning electron microscopy techniques. The process of organic pollutant (Acid Red 18) removal was carried out in a semi-batch photoreactor equipped with an ultraviolet lamp. Also, the influence of key operational parameters such as pH, temperature, initial concentration of solution, and nanophotocatalyst dosage was investigated to evaluate kinetic and thermodynamic properties...
November 19, 2018: Toxicology and Industrial Health
Jimian Yu, Wei Wang, Jianfeng Wang, Chun Wang, Caiyan Li
The objective of this study was to investigate changes in intestinal histopathology and expression of heat-shock proteins (HSPs) in the small intestinal tissue of mouse after acute exposure to dibutyl phthalate (DBP). Forty-eight 60-day-old Institute of Cancer Research (ICR) mice were administered DBP by gavage once a day for 10 days. The mice were divided into three groups of 16 mice each: the high-dose group was administered 500 mg/kg body weight (BW) DBP; the low-dose group was administered 50 mg/kg BW; and the control group was not administered DBP...
November 19, 2018: Toxicology and Industrial Health
Asghar Khodkar, Seyed Mostafa Khezri, Alireza Pendashteh, Shahrzad Khoramnejadian, Leila Mamani
In this study, a new magnetic α-Fe2 O3 @MIL-101(Cr)@TiO2 photocatalyst was successfully synthesized. The material synthesized had been fully characterized by Fourier transform infrared spectroscopy, scanning electron microscopy, energy-dispersive X-ray spectroscopy, vibrating sample magnetometry, transmission electron microscopy, and Brunauer-Emmett-Teller isotherm methods. The X-ray diffraction analysis corroborates that nanoparticles are polycrystalline with rhombohedral and tetragonal crystal structures for Fe2 O3 and TiO2 , respectively...
November 11, 2018: Toxicology and Industrial Health
Rajkumar Prabhakaran, Sebastin Nirmal Rajkumar, Tharmarajan Ramprasath, Govindan Sadasivam Selvam
Cadmium (Cd) remediation in Pseudomonas aeruginosa is achieved through the function of two vital genes, cadA and cadR, that code for P-type ATPase (CadA) and transcription regulatory protein (CadR), respectively. Although numerous studies are available on these metal-sensing and regulatory proteins, the promoter of these genes, metal sensing and binding ability, are poorly understood. The present work is aimed at the characterization of the CadR protein, identification of the P cadR promoter and protein-promoter-metal binding affinity using bioinformatics and to validate the results by cloning the P cadR promoter in Escherichia coli DH5α...
November 8, 2018: Toxicology and Industrial Health
Saraswati Saini, Inderpreet Kaur, Jatinder Kaur Katnoria
In the present study, the Allium cepa root chromosomal aberration assay was used to determine the genotoxic effects of copper and cadmium ions solutions before and after sorption processes. The sorption process was carried out using unmodified Dendrocalamus strictus charcoal powder, nitrilotriacetic acid (NTA)-modified D. strictus charcoal powder, and Saccharomyces cerevisiae. The frequency of total chromosomal aberrations was observed to be 24.30-45.13% for copper and 13.16-45.14% for cadmium at different concentrations (1-500 mg/l) before the sorption process...
November 1, 2018: Toxicology and Industrial Health
Qiu-Ping Liu, Dang-Xia Zhou, Mo-Qi Lv, Pan Ge, Yi-Xin Li, Shi-Jie Wang
Formaldehyde (FA), a ubiquitous environmental contaminant, has long been suspected of causing lung injury. However, the molecular and cellular mechanisms underlying this phenomenon remain elusive. The aim of this study was to elucidate the role of autophagy in lung injury induced by FA inhalation. In this study, lung weight coefficient, interleukin 8 in bronchoalveolar fluid, and histopathological examination were used to evaluate the lung injury. Moreover, electron microscopy, Western blotting for the ratio of LC3-II/LC3-I were used to detect autophagy in lung tissues...
October 25, 2018: Toxicology and Industrial Health
Basavalingappa Chaithra, Halugudde Nagaraja Sarjan, Shivabasavaiah
The present study was undertaken to investigate the toxic effects of sodium fluoride (NaF) on sperm motility and abnormality. Treatment of epididymal sperm suspensions with different doses of NaF (0.1, 1, 10, and 100 mg/ml) significantly reduced sperm motility at 15- and 30-min time intervals. Further, incubation at the same concentrations of NaF for 5-, 10-, and 15-min time intervals decreased sperm motility in a dose- and time-dependent manner. The present investigation revealed for the first time the adverse effect of lower doses of NaF (0...
October 25, 2018: Toxicology and Industrial Health
Doha M Beltagy, Kadry M Sadek, Amal S Hafez
β-glucuronidase (BG) activity is a promising biomarker for diagnosis and prognosis after exposure to organophosphorous (OP) pesticides. The aim of this study was to evaluate the changes in serum BG activity in patients with acute OP poisoning and to determine whether these changes correlate with the severity of poisoning. Thirty patients with anticholinesterase pesticide poisoning were included, besides 10 healthy volunteers as a control group. Serum activities of butyrylcholinesterase (BuChE) and BG were measured for each subject on admission, then after 12 and 24 h...
October 23, 2018: Toxicology and Industrial Health
Nawal A Ahmed, Nasr M Radwan, Heba S Aboul Ezz, Yasser A Khadrawy, Noha A Salama
The extensive use of mobile phones worldwide has raised increasing concerns about the effects of electromagnetic radiation (EMR) on the brain due to the proximity of the mobile phone to the head and the appearance of several adverse neurological effects after mobile phone use. It has been hypothesized that the EMR-induced neurological effects may be mediated by amino acid neurotransmitters. Thus, the present study investigated the effect of EMR (frequency 1800 MHz, specific absorption rate 0.843 W/kg, power density 0...
October 21, 2018: Toxicology and Industrial Health
Narges Karimi, Mahnaz Bayat, Masoud Haghani, Hamed Fahandezh Saadi, Gholam Reza Ghazipour
Microwave (MW) radiation has a close relationship with neurobehavioral disorders. Due to the widespread usage of MW radiation, especially in our homes, it is essential to investigate the direct effect of MW radiation on the central nervous system. Therefore, this study was carried out to determine the effect of MW radiation on memory and hippocampal synaptic plasticity. The rats were exposed to 2.45 GHz MW radiation (continuous wave with overall average power density of 0.016 mW/cm2 and overall average whole-body specific absorption rate value of 0...
October 21, 2018: Toxicology and Industrial Health
Esra Emerce, Özge Çetin
Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are synthetic chemicals that have been used in industry and consumer products. Because the presence of PFAS has been identified in humans and the environment in the last decade, human exposure to PFAS is a current public health concern. It has been shown that some PFAS lead to adverse health effects in the male reproductive system. However, there is no information about probable genotoxic effects of these chemicals on sperm cells. This study aimed to investigate the possible genotoxic damage on human sperm cells exposed to certain major PFAS compounds that were selected considering their extensive usage, high persistence in the environment, and high bioaccumulation in humans...
October 16, 2018: Toxicology and Industrial Health
Subhabrata Moitra, Jayashree Ghosh, Jannatul Firdous, Arghya Bandyopadhyay, Monojit Mondal, Jayanta Kumar Biswas, Subhashis Sahu, Soumya Bhattacharyya, Saibal Moitra
BACKGROUND: Despite the available clinico-epidemiological evidence of heavy metal-associated respiratory health hazards among metal arc-welders, experimental confirmation of such an association is lacking. METHODS: In this study, we recruited 15 metal arc-welders and 10 referent workers without direct exposure. We assessed respiratory health through a questionnaire and spirometry; estimated manganese, nickel and cadmium levels in blood, urine and induced sputum; performed differential counts of sputum leucocytes and measured plasma malondialdehyde (MDA)...
October 14, 2018: Toxicology and Industrial Health
Benyu Su, Qiangdong Guan, Sufang Yu
The aim of this study was to evaluate the global scientific output of neurotoxicity of nanoparticles (NPs) and explore their hot spots and research trends. Articles about the neurotoxicity of NPs between 2008 and 2017 were taken from the Web of Science Core Collection database. The VOSviewer was used to analyze annual publications, countries/institutions, funding agencies, research objects, major journals, and international cooperation. The reference co-citation map and keywords were used to analyze the mechanisms of neurotoxicity of NPs...
October 14, 2018: Toxicology and Industrial Health
Maryam Afshari, Jalal Poorolajal, Mohammad Javad Assari, Forouzan Rezapur-Shahkolai, Akram Karimi-Shahanjarini
Although acute pesticide poisoning (APP) is known to be a major health concern among farmers in developing countries, knowledge of its prevalence and risk factors is limited. The purpose of this study was to investigate the prevalence and a broad range of potential work-related risk factors of APP among Iranian farmers and farm workers. This cross-sectional study was conducted in rural areas of the Twiserkan County in Iran. In this study, there were 474 farmers and farm workers who had used pesticide 1 week before data collection...
October 3, 2018: Toxicology and Industrial Health
Tapan A Patel, Mandava V Rao
Melatonin (MLT) is an extraordinary antioxidant, which plays an important role in reducing reactive oxygen species (ROS) by scavenging them directly or indirectly. Mercury (Hg) is a heavy metal, which induces cytogenetic alterations via various mechanisms, leading to genotoxicity. It induces genotoxicity by enhancing the ROS chiefly. In the present study, the antigenotoxic effect of MLT was evaluated against mercuric chloride (HgCl2 ). All experiments were conducted in vitro in peripheral blood lymphocytes...
October 3, 2018: Toxicology and Industrial Health
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