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Toxicology and Industrial Health

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https://www.readbyqxmd.com/read/30317941/exposure-to-heavy-metals-alters-the-surface-topology-of-alveolar-macrophages-and-induces-respiratory-dysfunction-among-indian-metal-arc-welders
#1
Subhabrata Moitra, Jayashree Ghosh, Jannatul Firdous, Arghya Bandyopadhyay, Monojit Mondal, Jayanta Kumar Biswas, Subhashis Sahu, Soumya Bhattacharyya, Saibal Moitra
BACKGROUND: Despite the available clinico-epidemiological evidence of heavy metal-associated respiratory health hazards among metal arc-welders, experimental confirmation of such an association is lacking. METHODS: In this study, we recruited 15 metal arc-welders and 10 referent workers without direct exposure. We assessed respiratory health through a questionnaire and spirometry; estimated manganese, nickel and cadmium levels in blood, urine and induced sputum; performed differential counts of sputum leucocytes and measured plasma malondialdehyde (MDA)...
October 14, 2018: Toxicology and Industrial Health
https://www.readbyqxmd.com/read/30317940/the-neurotoxicity-of-nanoparticles-a-bibliometric-analysis
#2
Benyu Su, Qiangdong Guan, Sufang Yu
The aim of this study was to evaluate the global scientific output of neurotoxicity of nanoparticles (NPs) and explore their hot spots and research trends. Articles about the neurotoxicity of NPs between 2008 and 2017 were taken from the Web of Science Core Collection database. The VOSviewer was used to analyze annual publications, countries/institutions, funding agencies, research objects, major journals, and international cooperation. The reference co-citation map and keywords were used to analyze the mechanisms of neurotoxicity of NPs...
October 14, 2018: Toxicology and Industrial Health
https://www.readbyqxmd.com/read/30278839/acute-pesticide-poisoning-and-related-factors-among-farmers-in-rural-western-iran
#3
Maryam Afshari, Jalal Poorolajal, Mohammad Javad Assari, Forouzan Rezapur-Shahkolai, Akram Karimi-Shahanjarini
Although acute pesticide poisoning (APP) is known to be a major health concern among farmers in developing countries, knowledge of its prevalence and risk factors is limited. The purpose of this study was to investigate the prevalence and a broad range of potential work-related risk factors of APP among Iranian farmers and farm workers. This cross-sectional study was conducted in rural areas of the Twiserkan County in Iran. In this study, there were 474 farmers and farm workers who had used pesticide 1 week before data collection...
October 3, 2018: Toxicology and Industrial Health
https://www.readbyqxmd.com/read/30278831/antigenotoxic-effect-of-melatonin-against-mercuric-chloride-in-human-peripheral-blood-lymphocytes
#4
Tapan A Patel, Mandava V Rao
Melatonin (MLT) is an extraordinary antioxidant, which plays an important role in reducing reactive oxygen species (ROS) by scavenging them directly or indirectly. Mercury (Hg) is a heavy metal, which induces cytogenetic alterations via various mechanisms, leading to genotoxicity. It induces genotoxicity by enhancing the ROS chiefly. In the present study, the antigenotoxic effect of MLT was evaluated against mercuric chloride (HgCl2 ). All experiments were conducted in vitro in peripheral blood lymphocytes...
October 3, 2018: Toxicology and Industrial Health
https://www.readbyqxmd.com/read/30269681/inhibition-of-catalase-activity-with-3-amino-1-2-4-triazole-intensifies-bisphenol-a-bpa-induced-toxicity-in-granulosa-cells-of-female-albino-rats
#5
Oly Banerjee, Siddhartha Singh, Shilpi Kumari Prasad, Ankita Bhattacharjee, Arnab Banerjee, Anindita Banerjee, Adipa Saha, Bithin Kumar Maji, Sandip Mukherjee
Exposure to bisphenol A (BPA), an endocrine disruptor and environmental toxicant, is associated with adverse estrogenic effects in both humans and wildlife species. Because the effects of BPA on the ovary at the cellular level are incompletely understood, the present study was designed to investigate the underlying mechanism of granulosa cell injury following BPA exposure. Eight-week-old female Wistar rats were treated with BPA (25 mg/kg BW/day for 9 days, intraperitonially) with or without pretreatment of the catalase-specific blocker 3-amino-1,2,4-triazole (ATZ; 1 g/kg BW/day for 5 days, intraperitonially)...
October 1, 2018: Toxicology and Industrial Health
https://www.readbyqxmd.com/read/30231772/maternal-exposure-to-di-n-butyl-phthalate-induces-changes-in-c-myc-apoptotic-and-growth-related-genes-in-the-testes-of-male-rat-pups
#6
Maha M Rashad, Mona K Galal, Adel M El-Behairy, Eman M Gouda, Said Z Moussa
The aim of this study was to investigate the effects of maternal exposure to di-( n-butyl) phthalate (DBP) on testicular development and function in pre-pubertal and post-pubertal male rat offspring. Fourteen pregnant female rats were equally divided into two groups: a control group and a DBP-treated group. During gestation day (GD) 12 to postnatal day (PND) 14, the control group was administered 1 ml/day corn oil, and the DBP-treated group was administered DBP 500 mg/kg/day by oral gavage. On PND 25 (pre-puberty) and PND 60 (post-puberty), blood for serum and the testes were collected from five male offspring of each group...
September 19, 2018: Toxicology and Industrial Health
https://www.readbyqxmd.com/read/30227779/synthesis-characterization-and-pharmacological-evaluation-of-zinc-oxide-nanoparticles-formulation
#7
Zulfia Hussain, Junaid Ali Khan, Hafeez Anwar, Naila Andleeb, Sehrish Murtaza, Ambreen Ashar, Iram Arif
Zinc oxide nanoparticles (ZnONPs) are being used extensively in manufacturing skin lotions and food products and in various biological and pharmaceutical industries because of their immunomodulatory and antimicrobial properties. In this study, ZnONPs were synthesized by a precipitation method and characterized by X-ray diffraction (XRD) techniques, scanning electron microscopy (SEM), and ultraviolet-visible spectroscopy to investigate their structural, morphological, and optical properties. For in vivo evaluation, 40 healthy albino mice were randomly allocated to four equal groups among which the first one was the control group, while the second, third, and fourth were treated with carbon tetrachloride (CCl4 ), a blend of CCl4 and ZnONPs, and ZnONPs alone, respectively, for 21 days...
September 18, 2018: Toxicology and Industrial Health
https://www.readbyqxmd.com/read/30227778/cytogenetic-alterations-induced-by-flupyradifurone-a-new-butenolide-insecticide-in-human-lymphocytes
#8
Zülal Atlı Şekeroğlu, Adem Aydın, Seval Kontaş Yedier, Vedat Şekeroğlu
Flupyradifurone (FPD), a member of the new class of butenolide insecticides, acts on nicotinic acetylcholine receptors. Studies on genotoxic and carcinogenic effects of FPD are very limited. This is the first study to investigate the cytotoxic and genotoxic effects of FPD and its metabolites on human lymphocyte cultures with or without a metabolic activation system (S9 mix) using chromosomal aberration (CA) and micronucleus (MN) tests. The cultures were treated with 85, 170, and 340 µg/ml of FPD in the presence (3 h treatment) and absence (48 h treatment) of S9 mix...
September 18, 2018: Toxicology and Industrial Health
https://www.readbyqxmd.com/read/30185115/corrigendum
#9
(no author information available yet)
No abstract text is available yet for this article.
September 5, 2018: Toxicology and Industrial Health
https://www.readbyqxmd.com/read/30122117/malathion-toxicity-and-lipid-emulsion
#10
Ju-Tae Sohn
No abstract text is available yet for this article.
August 19, 2018: Toxicology and Industrial Health
https://www.readbyqxmd.com/read/30033852/risk-estimation-and-multivariate-statistical-analysis-of-the-heavy-metal-content-of-drinking-water-samples
#11
Rajan Jakhu, Rohit Mehra
Drinking water samples of Jaipur and Ajmer districts of Rajasthan, India, were collected and analyzed for the measurement of concentration of heavy metals. The purpose of this study was to determine the sources of the heavy metals in the drinking water. Inductively coupled plasma mass spectrometry was used for the determination of the heavy metal concentrations, and for the statistical analysis of the data, principal component analysis and cluster analysis were performed. It was observed from the results that with respect to WHO guidelines, the water samples of some locations exceeded the contamination levels for lead (Pb), selenium (Se), and mercury (Hg), and with reference to the EPA guidelines, the samples were determined unsuitable for drinking because of high concentrations of Pb and Hg...
October 2018: Toxicology and Industrial Health
https://www.readbyqxmd.com/read/30033815/toxic-effects-of-imidacloprid-combined-with-arsenic-oxidative-stress-in-rat-liver
#12
Lakshay Mahajan, Pawan Kumar Verma, Rajinder Raina, Shilpa Sood
Imidacloprid (IMI), a newer neonicotinoid insecticide, induces oxidative insult to hepatocytes due to the formation of reactive metabolites during hepatic metabolism. The present study aimed to determine the potentiating effect of arsenic (As) on IMI-induced hepatic damage in Wistar rats. Rats, randomly divided into eight groups with six in each, were subjected to daily oral administration for 28 days. Group I served as control; group II received IMI at the dose rate of 16.9 mg/kg body weight; groups III, IV, and V received As at the dose rate of 50, 100, and 150 ppb, respectively, in drinking water; groups VI, VII, and VIII received both IMI (16...
October 2018: Toxicology and Industrial Health
https://www.readbyqxmd.com/read/30033812/acute-inhalation-toxicity-study-of-n-heneicosane-and-its-combination-with-diflubenzuron-an-attracticide-of-aedes-aegypti
#13
Anshoo Gautam, Deeksha Singh, Peeyush Shrivastava, R Vijayaraghavan
OBJECTIVE: Combination of an oviposition pheromone and an insect growth regulator for the control of vectors is an effective approach. There is a need for toxicological evaluation before its introduction. The present study evaluates the acute inhalation toxicity of n-heneicosane and its combination with diflubenzuron in a head-only inhalation exposure chamber made of glass. MATERIALS AND METHODS: A head-only inhalation exposure chamber made of glass (volume: 3.5 l) was used for exposing four rats at a time...
October 2018: Toxicology and Industrial Health
https://www.readbyqxmd.com/read/30009691/effects-of-900-mhz-electromagnetic-fields-exposure-throughout-middle-late-adolescence-on-the-kidney-morphology-and-biochemistry-of-the-female-rat
#14
Derya Öztürk Okatan, Ali Ertan Okatan, Hatice Hancı, Selim Demir, Serap Özer Yaman, Serdar Çolakoğlu, Ersan Odacı
The effect of the electromagnetic field (EMF) established when cell phones are in use on human health, and particularly the head, has been the subject of major scientific research. Phones are usually carried near the lumbar region when not in use, and the kidneys will also inevitably be affected by such fields. We investigated the effects on the kidneys of female rats exposed to a continuous 900-megahertz (MHz) EMF for 1 h daily in mid-late adolescence. Control, sham, and EMF groups were established. The EMF was applied to the application group rats daily on postnatal days 35-59...
October 2018: Toxicology and Industrial Health
https://www.readbyqxmd.com/read/30003843/stone-quarrying-induces-organ-dysfunction-and-oxidative-stress-in-meriones-libycus
#15
Fahed S Al-Otaibi, Jamaan S Ajarem, Mostafa A Abdel-Maksoud, Saleh Maodaa, Ahmed A Allam, Gadh I Al-Basher, Ayman M Mahmoud
Exposure to heavy metal-containing dust arising from stone quarrying may cause severe health problems. The aim of this study was to evaluate the impact of stone quarrying in Riyadh (Saudi Arabia) on the Libyan jird Meriones libycus. Soil samples and jirds were collected from four sites located at different distances from the quarrying area. Soil from the first (500 m away from the quarry) and second (1800 m away) sites showed a significant increase in cadmium (Cd), lead (Pb), nickel (Ni), and vanadium (V) when compared with the reference site (38,000 m away)...
October 2018: Toxicology and Industrial Health
https://www.readbyqxmd.com/read/30003842/effect-of-developmental-lead-exposure-on-neurogenesis-and-cortical-neuronal-morphology-in-wistar-rats
#16
Alyaa M A Mousa, Mona A Elshahat, Waleed M Renno
Lead (Pb) is a neurotoxic heavy metal that largely affects the developing nervous system. The present study examined the temporal effect of perinatal Pb exposure on neurogenesis and cortical neuronal morphology. Wistar pregnant rats were exposed to 0.5% lead acetate throughout pregnancy and to postnatal day (PD) 28. Offspring were grouped as gestational day (GD) 18 and 21 and PD 7, 14, 21, and 28 in both control and experimental groups. Brain sections were processed for immunohistological staining with anti-proliferating cell nuclear antigen (PCNA) or glial fibrillary acidic protein (GFAP)...
October 2018: Toxicology and Industrial Health
https://www.readbyqxmd.com/read/30024837/corrigendum
#17
(no author information available yet)
No abstract text is available yet for this article.
September 2018: Toxicology and Industrial Health
https://www.readbyqxmd.com/read/30003841/comparative-evaluation-of-half-maximum-inhibitory-concentration-and-cytotoxicity-of-silver-nanoparticles-and-multiwalled-carbon-nanotubes-using-buffalo-bull-spermatozoa-as-a-cell-model
#18
Sandhya Sanand, Sandeep Kumar, Nisha Bara, Gautam Kaul
There is a dearth of information regarding the safety of silver nanoparticles (Ag NPs) and multiwalled carbon nanotubes (MWCNTs) with respect to their impact on human/animal health and the environment. This study aimed to determine the half-maximum inhibitory concentration (IC50 ) of Ag NPs and MWCNTs by employing different doses and time interval combinations in buffalo bull spermatozoa. Semen samples containing 100 million spermatozoa each were incubated with 1, 10, 25, 50, 75 and 100 µg/mL of Ag NPs and MWCNTs at 37°C for 30, 60 and 120 min...
September 2018: Toxicology and Industrial Health
https://www.readbyqxmd.com/read/30003840/chronic-co-exposure-to-low-levels-of-brominated-flame-retardants-and-heavy-metals-induces-reproductive-toxicity-in-zebrafish
#19
Jiangfei Chen, Xue Ma, Linjie Tian, Aijun Kong, Nengzhuang Wang, Changjiang Huang, Dongren Yang
Brominated flame retardants (BFRs) and heavy metals (HMs) are two main types of pollutants in electronic waste recycling sites, which are also ubiquitously detectable in environmental media and human tissues. However, the adverse health effects of exposure to the mixture of these types of pollutants are unknown. In this study, we investigated the reproductive toxicity of a mixture of decabromodiphenyl ether (BDE-209), tetrabromobisphenol A, cadmium chloride, and lead acetate (PbAc) at the environmental relevant levels...
September 2018: Toxicology and Industrial Health
https://www.readbyqxmd.com/read/29996728/mechanisms-of-diazinon-effects-on-impaired-spermatogenesis-and-male-infertility
#20
Asghar Beigi Harchegani, Alireza Rahmani, Eisa Tahmasbpour, Hamid Bakhiari Kabootaraki, Hossein Rostami, Alireza Shahriary
Diazinon (DZN) is an organophosphate insecticide that has cytotoxic and pathological effects on the reproductive system. It causes a wide variety of pathological effects on the reproductive system such as testicular atrophy, disturbance in sex hormones, impaired spermatogenesis, low quality of sperm, and fertility problems. However, molecular and cellular mechanisms of its adverse effects are not well understood. General events such as testicular damage, inflammation, mitochondrial deficiency, DNA fragmentation, disintegration of sperm plasma membrane, apoptosis, and cell death are observed in DZN-exposed animals...
September 2018: Toxicology and Industrial Health
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