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Heart and Vessels

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https://www.readbyqxmd.com/read/29464342/vascular-response-to-biolimus-a-9-eluting-stent-in-patients-with-shorter-and-prolonged-dual-antiplatelet-therapy-optical-coherence-tomography-sub-study-of-the-nippon-trial
#1
Koji Kuroda, Toshiro Shinke, Hiromasa Otake, Hiroto Kinutani, Raisuke Iijima, Junya Ako, Hisayuki Okada, Yoshiaki Ito, Kenji Ando, Hitoshi Anzai, Hiroyuki Tanaka, Yasunori Ueda, Shin Takiuchi, Yasunori Nishida, Hiroshi Ohira, Katsuhiro Kawaguchi, Makoto Kadotani, Hiroyuki Niinuma, Kazuto Omiya, Takashi Morita, Kan Zen, Yoshinori Yasaka, Kenji Inoue, Sugao Ishiwata, Masahiko Ochiai, Toshimitsu Hamasaki, Kazushi Urasawa, Toru Kataoka, Minoru Yoshiyama, Kenshi Fujii, Takumi Inoue, Masahito Kawata, Hiroyoshi Yokoi, Masato Nakamura
Dual antiplatelet therapy (DAPT) with thienopyridine and aspirin is the standard care for the prevention of stent thrombosis. However, the optimal duration and effect of the duration of DAPT on intra-stent thrombus (IS-Th) formation are unknown. The NIPPON study (Nobori Dual Antiplatelet Therapy as Appropriate Duration) was an open label, randomized multicenter, assessor-blinded, trial designed to demonstrate the non-inferiority of shorter (6-month) DAPT to prolonged (18-month) DAPT, after biolimus A9 eluting stent implantation in 3773 patients at 130 sites in Japan...
February 20, 2018: Heart and Vessels
https://www.readbyqxmd.com/read/29464341/additional-cryoapplications-at-the-pulmonary-vein-antrum-using-a-28-mm-second-generation-cryoballoon-a-pilot-study-of-extra-pulmonary-vein-ablation
#2
Shinsuke Miyazaki, Takatsugu Kajiyama, Tomonori Watanabe, Sadamitsu Ichijo, Yoshito Iesaka
Isolation areas post-28-mm cryoballoon pulmonary vein isolation (CB-PVI) are smaller than post-radiofrequency PV antrum isolation at the left superior PV (LSPV) antrum and recurrent atrial fibrillation (AF) can originate from this area. This pilot study evaluated the impact of additional extra-PV CB applications at the LSPV antrum following conventional CB-PVI. Eighteen paroxysmal AF patients underwent CB-PVI with single 3-min freeze techniques. Following the CB-PVI, 2-min CB applications were added once or twice at the LSPV antrum...
February 20, 2018: Heart and Vessels
https://www.readbyqxmd.com/read/29464340/correction-to-high-intensity-aerobic-interval-training-can-lead-to-improvement-in-skeletal-muscle-power-among-in-hospital-patients-with-advanced-heart-failure
#3
Masanobu Taya, Eisuke Amiya, Masaru Hatano, Hisataka Maki, Daisuke Nitta, Akihito Saito, Masaki Tsuji, Yumiko Hosoya, Shun Minatsuki, Atsuko Nakayama, Takayuki Fujiwara, Yuto Konishi, Kazuhiko Yokota, Masafumi Watanabe, Hiroyuki Morita, Nobuhiko Haga, Issei Komuro
In the original publication of the article, the unit of hand in Fig. 2 was wrongly given as "N/kg" instead of "kg".
February 20, 2018: Heart and Vessels
https://www.readbyqxmd.com/read/29460022/correction-to-association-between-discordance-of-ldl-c-and-non-hdl-c-and-clinical-outcomes-in-patients-with-stent-implantation-from-the-fu-registry
#4
Michiyo Shiiba, Bo Zhang, Shin-Ichiro Miura, Amane Ike, Daisuke Nose, Takashi Kuwano, Satoshi Imaizumi, Makoto Sugihara, Atushi Iwata, Hiroaki Nishikawa, Akira Kawamura, Kazuyuki Shirai, Shin'ichiro Yasunaga, Keijiro Saku
Unfortunately, the Fig. 1 was published incorrectly in the original publication of the article. The correct figure is as below.
February 19, 2018: Heart and Vessels
https://www.readbyqxmd.com/read/29455380/clinical-features-and-peripartum-outcomes-in-pregnant-women-with-cardiac-disease-a-nationwide-retrospective-cohort-study-in-japan
#5
Toshiaki Isogai, Hiroki Matsui, Hiroyuki Tanaka, Akira Kohyama, Kiyohide Fushimi, Hideo Yasunaga
Although the number of pregnancies in women with cardiac disease is increasing worldwide, there are few data concerning their clinical characteristics and peripartum outcomes. Using the Diagnosis Procedure Combination database between 2008 and 2014 in Japan, we retrospectively identified pregnant women who underwent high-risk delivery due to obstetric or non-obstetric comorbidities. We classified eligible women into those with pre-existing cardiac disease (cardiac disease group) and those with non-cardiac comorbidities (non-cardiac disease group) and compared their characteristics and peripartum outcomes...
February 17, 2018: Heart and Vessels
https://www.readbyqxmd.com/read/29450689/the-first-multicenter-randomized-controlled-trial-of-home-telemonitoring-for-japanese-patients-with-heart-failure-home-telemonitoring-study-for-patients-with-heart-failure-homes-hf
#6
Norihiko Kotooka, Masafumi Kitakaze, Kengo Nagashima, Machiko Asaka, Yoshiharu Kinugasa, Kotaro Nochioka, Atsushi Mizuno, Daisuke Nagatomo, Daigo Mine, Yoko Yamada, Akiko Kuratomi, Norihiro Okada, Daisuke Fujimatsu, So Kuwahata, Shigeru Toyoda, Shin-Ichi Hirotani, Takahiro Komori, Kazuo Eguchi, Kazuomi Kario, Takayuki Inomata, Kaoru Sugi, Kazuhiro Yamamoto, Hiroyuki Tsutsui, Tohru Masuyama, Hiroaki Shimokawa, Shin-Ichi Momomura, Yoshihiko Seino, Yasunori Sato, Teruo Inoue, Koichi Node
Home telemonitoring is becoming more important to home medical care for patients with heart failure. Since there are no data on home telemonitoring for Japanese patients with heart failure, we investigated its effect on cardiovascular outcomes. The HOMES-HF study was the first multicenter, open-label, randomized, controlled trial (RCT) to elucidate the effectiveness of home telemonitoring of physiological data, such as body weight, blood pressure, and pulse rate, for Japanese patients with heart failure (UMIN Clinical Trials Registry 000006839)...
February 15, 2018: Heart and Vessels
https://www.readbyqxmd.com/read/29445930/zbtb17-loss-of-function-mutation-contributes-to-familial-dilated-cardiomyopathy
#7
Yu-Min Sun, Jun Wang, Ying-Jia Xu, Xin-Hua Wang, Fang Yuan, Hua Liu, Ruo-Gu Li, Min Zhang, Yan-Jie Li, Hong-Yu Shi, Liang Zhao, Xing-Biao Qiu, Xin-Kai Qu, Yi-Qing Yang
Dilated cardiomyopathy (DCM) is a common primary myocardial disease leading to congestive heart failure, arrhythmia and sudden cardiac death. Increasing studies demonstrate substantial genetic determinants for DCM. Nevertheless, DCM is of substantial genetic heterogeneity, and the genetic basis for DCM in most patients remains unclear. The present study was sought to investigate the association of a genetic variant in the ZBTB17 gene with DCM. A cohort of 158 unrelated patients with idiopathic DCM and a total of 230 unrelated, ethnically matched healthy individuals used as controls were recruited...
February 14, 2018: Heart and Vessels
https://www.readbyqxmd.com/read/29441403/sex-differences-in-hemodynamic-responses-and-long-term-survival-to-optimal-medical-therapy-in-patients-with-pulmonary-arterial-hypertension
#8
Katsuya Kozu, Koichiro Sugimura, Tatsuo Aoki, Shunsuke Tatebe, Saori Yamamoto, Nobuhiro Yaoita, Toru Shimizu, Kotaro Nochioka, Haruka Sato, Ryo Konno, Kimio Satoh, Satoshi Miyata, Hiroaki Shimokawa
It is widely known that the incidence of pulmonary arterial hypertension (PAH) is higher in female, whereas prognosis is poorer in male patients. However, sex differences in hemodynamic response to and long-term prognosis with PAH-targeted treatment in the modern era remain to be fully elucidated. We examined the long-term prognosis of 129 consecutive PAH patients (34 males and 95 females) diagnosed in our hospital from April 1999 to October 2014, and assessed hemodynamic changes in response to PAH-targeted therapy...
February 13, 2018: Heart and Vessels
https://www.readbyqxmd.com/read/29435641/wave-intensity-as-a-useful-modality-for-assessing-ventilation-perfusion-imbalance-in-subclinical-patients-with-hypertension
#9
Yoshie Nogami, Yoshihiro Seo, Masayoshi Yamamoto, Tomoko Ishizu, Kazutaka Aonuma
Wave intensity (WI) is a novel noninvasive index of circulatory dynamics that reflects ventriculo-arterial coupling. It is calculated as the product of the first derivative of blood pressure and that of flow velocity measured by carotid echocardiography. This study aimed to clarify the clinical implications of WI and its relation with carbon dioxide production (VE/VCO 2 slope). Twenty-one healthy volunteers (control group) and 21 patients with hypertension (HT group) underwent cardiopulmonary exercise testing (CPX) and exercise stress echocardiography...
February 12, 2018: Heart and Vessels
https://www.readbyqxmd.com/read/29435640/feasibility-and-safety-of-outpatient-cardiac-catheterization-with-intracoronary-acetylcholine-provocation-test
#10
Yuichi Saito, Hideki Kitahara, Toshihiro Shoji, Satoshi Tokimasa, Takashi Nakayama, Kazumasa Sugimoto, Yoshihide Fujimoto, Yoshio Kobayashi
Intracoronary acetylcholine (ACh) provocation test is useful to diagnose vasospastic angina. Although outpatient coronary angiography has been widely performed in current clinical settings, the feasibility and safety of ACh provocation test in outpatient services are unclear. A total of 323 patients, who electively underwent ACh provocation test in hospitalization and outpatient services, were included. Coronary angiography was performed after insertion of a temporary pacing electrode in the right ventricle...
February 12, 2018: Heart and Vessels
https://www.readbyqxmd.com/read/29427024/comparison-of-the-effects-of-linagliptin-and-voglibose-on-endothelial-function-in-patients-with-type-2-diabetes-and-coronary-artery-disease-a-prospective-randomized-pilot-study-effort
#11
Taku Koyama, Atsushi Tanaka, Hisako Yoshida, Jun-Ichi Oyama, Shigeru Toyoda, Masashi Sakuma, Teruo Inoue, Yoritaka Otsuka, Koichi Node
Endothelial dysfunction contributes to poor cardiovascular prognosis in patients with type 2 diabetes mellitus (T2DM) and coronary artery disease (CAD). The effect of dipeptidyl peptidase-4 inhibitors on endothelial function remains controversial. We sought to compare the effects of linagliptin and voglibose on endothelial function, as assessed by reactive hyperemia-peripheral arterial tonometry (RH-PAT). Sixteen patients with newly diagnosed T2DM and CAD were randomized 1:1 to linagliptin (5 mg, once-daily) or voglibose (0...
February 9, 2018: Heart and Vessels
https://www.readbyqxmd.com/read/29417224/influence-of-dietary-iron-intake-restriction-on-the-development-of-hypertension-in-weanling-prehypertensive-rats
#12
Keisuke Okuno, Yoshiro Naito, Seiki Yasumura, Hisashi Sawada, Makiko Oboshi, Koichi Nishimura, Masanori Asakura, Masaharu Ishihara, Tohru Masuyama
Hypertension is a major public health problem leading to death. To reduce the morbidity and mortality in patients with hypertension, it is crucial to develop a novel strategy for prevention of hypertension. We have currently reported an attempt at dietary iron intake restriction as non-pharmacological treatment of hypertension in patients with hypertension. However, it remains fully unknown whether dietary iron restriction prevents the development of hypertension. We investigated the influence of dietary iron restriction on the development of hypertension in weanling pre-hypertensive model rats...
February 7, 2018: Heart and Vessels
https://www.readbyqxmd.com/read/29417223/relationship-between-blood-urea-nitrogen-to-creatinine-ratio-at-hospital-admission-and-long-term-mortality-in-patients-with-acute-decompensated-heart-failure
#13
Azusa Murata, Takatoshi Kasai, Yuya Matsue, Hiroki Matsumoto, Shoichiro Yatsu, Takao Kato, Shoko Suda, Masaru Hiki, Atsutoshi Takagi, Hiroyuki Daida
Although elevated blood urea nitrogen (BUN)-to-creatinine (BUN/Cr) ratio at hospital admission has been reported to be associated with poor short-term prognosis, its association to long-term mortality in patients with acute decompensated heart failure (ADHF) remains to be elucidated. Moreover, an additive prognostic value to preexisting renal markers including creatinine and BUN has not been well described. A cohort of 557 consecutive ADHF patients admitted to the cardiac intensive care unit was studied. All cohorts were divided into high and low BUN/Cr ratios according to the median value of BUN/Cr ratio at admission...
February 7, 2018: Heart and Vessels
https://www.readbyqxmd.com/read/29396769/right-minithoracotomy-versus-conventional-median-sternotomy-for-patients-undergoing-mitral-valve-surgery-and-cox-maze-iv-ablation-with-entirely-bipolar-radiofrequency-clamp
#14
Zhaolei Jiang, Min Tang, Nan Ma, Hao Liu, Fangbao Ding, Chunrong Bao, Ju Mei
Cox-maze IV ablation by bipolar radiofrequency clamp was considered to be only performed through median sternotomy (MS), but impossible through right minithoracotomy (RM). Now, we developed a novel technique of performing Cox-maze IV ablation entirely by bipolar clamp through RM. To compare the outcomes of RM or MS for patients undergoing mitral valve surgery and concomitant Cox-maze IV ablation with entirely bipolar clamp. All 152 patients underwent mitral valve surgery and concomitant Cox-maze IV ablation with bipolar clamp through RM (n = 69) or MS (n = 83) were analyzed for outcome differences...
February 2, 2018: Heart and Vessels
https://www.readbyqxmd.com/read/29396768/the-relationship-between-medical-expenses-and-the-severity-of-peripheral-arterial-disease-in-japan
#15
Akihiko Seo, Kota Yamamoto, Atsushi Akai, Daisuke Akagi, Toshio Takayama, Katsuyuki Hoshina
The main objective is to examine whether the severity of peripheral arterial disease (PAD) affects the expenses and hospital stay of the patients who undergo bypass surgery below the inguinal ligament for PAD. Eighty consecutive patients who underwent infrainguinal bypass surgery for PAD between January 2012 and December 2014 were included in the study. Patients were divided into groups according to their critical limb ischemia (CLI) symptoms and the Wound, Ischemia, and Foot Infection (WIfI) classification...
February 2, 2018: Heart and Vessels
https://www.readbyqxmd.com/read/29392470/heart-failure-with-preserved-vs-reduced-ejection-fraction-following-cardiac-rehabilitation-impact-of-endothelial-function
#16
Seiya Tanaka, Yoshihito Sanuki, Kiyoshi Ozumi, Takashi Harada, Hiromi Tasaki
There is no proven therapy for heart failure with preserved ejection fraction (HFpEF). Research has shown beneficial responses to cardiac rehabilitation (CR) among HF patients. To date, there are no reports comparing those responses between patients with HFpEF and those with reduced ejection fraction (HFrEF). The purpose of this study was to compare responses to CR in patients with HFpEF versus those with HFrEF. We included 78 consecutive patients (mean age 69 ± 15 years; 80% male) with HF in our CR unit who underwent cardiopulmonary exercise testing and brachial artery flow-mediated dilation (FMD) testing pre- and 5 months post-CR...
February 1, 2018: Heart and Vessels
https://www.readbyqxmd.com/read/29387924/anatomical-features-of-the-aortic-root-in-aortic-stenosis-and-a-novel-approach-for-transcatheter-aortic-valve-implantation
#17
Norio Tada, Teruo Inoue, Takashi Matsumoto, Mie Sakurai, Yukiko Mizutani, Yusuke Enta, Kazunori Ishii, Hiroshi Inoue, Masataka Taguri, Masaki Hata, Masashi Sakuma, Shigeru Toyoda, Tatsushi Ootomo
A narrow and calcified sinotubular junction (STJ) represents a risk for ascending aortic dissection after balloon-expandable transcatheter aortic valve implantation (TAVI). The aim of this study was to assess computed tomography (CT)-based aortic root morphology in patients with aortic stenosis (AS), and to evaluate the feasibility of a two-step inflation technique that we devised for TAVI using the SAPIEN 3 in patients with a narrow and calcified STJ. We retrospectively analyzed the STJ diameter (STJD) as well the as aortic annulus diameter (AAD) and STJ calcification using CT imaging in 412 patients undergoing TAVI...
January 31, 2018: Heart and Vessels
https://www.readbyqxmd.com/read/29387923/association-between-histological-features-of-epicardial-adipose-tissue-and-coronary-plaque-characteristics-on-computed-tomography-angiography
#18
Atsuhiro Senoo, Toshiro Kitagawa, Shinya Torimaki, Hideya Yamamoto, Kazuhiro Sentani, Shinya Takahashi, Yumiko Kubo, Wataru Yasui, Taijiro Sueda, Yasuki Kihara
The means by which epicardial adipose tissue (EAT) could influence coronary plaque progression biologically remain unclear. We investigated the association between the histological findings of EAT and coronary plaque characteristics assessed by coronary computed tomography angiography (CCTA). We enrolled 34 patients in whom one or more coronary plaques containing non-calcified components were detected on CCTA before cardiac surgery [coronary artery bypass graft (CABG) or non-CABG]. We evaluated visceral adipose tissue (VAT) area, EAT volume, and coronary plaque characteristics including minimum computed tomography density (CTD) and vascular Remodeling Index (RI)...
January 31, 2018: Heart and Vessels
https://www.readbyqxmd.com/read/29380048/endothelial-function-in-children-with-white-coat-hypertension
#19
Alexander Jurko, Tomas Jurko, Milan Minarik, Michal Mestanik, Andrea Mestanikova, Vladimir Micieta, Zuzana Visnovcova, Ingrid Tonhajzerova
Several studies have demonstrated endothelial dysfunction in patients with essential hypertension. However, the presence of endothelial dysfunction in children with white-coat hypertension has not been studied. We evaluated the endothelial function in children with white-coat hypertension and essential hypertension using a novel method based on the assessment of flow-mediated dilation (FMD). Study involved 106 children: 30 white-coat hypertensives (age 16.3 ± 1.3 years, mean ± SD), 30 essential hypertensives (age 16...
January 29, 2018: Heart and Vessels
https://www.readbyqxmd.com/read/29368166/long-term-physical-activity-leads-to-a-significant-increase-in-serum-srage-levels-a-sign-of-decreased-age-mediated-inflammation-due-to-physical-activity
#20
Michael Sponder, Ioana-Alexandra Campean, Michael Emich, Monika Fritzer-Szekeres, Brigitte Litschauer, Senta Graf, Daniel Dalos, Jeanette Strametz-Juranek
There is growing evidence that low levels of the circulating soluble receptor of advanced glycation end products (sRAGE) are a valuable predictor of cardiovascular disease (CVD). The aim of this prospective study was to investigate the influence of long-term physical activity on serum sRAGE levels. 109 subjects were recruited, and 98 completed the study. Participants were asked to perform exercise within the calculated training pulse for 8 months. The performance gain was measured/quantified by bicycle stress tests at the beginning and end of the observation period...
January 24, 2018: Heart and Vessels
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