Read by QxMD icon Read

Heart and Vessels

Kei Yamamoto, Kenichi Sakakura, Naoyuki Akashi, Yusuke Watanabe, Masamitsu Noguchi, Yousuke Taniguchi, Hiroshi Wada, Shin-Ichi Momomura, Hideo Fujita
In primary percutaneous coronary intervention (PCI), revascularization to the main branch is considered to be more important than that to the side branch. The purpose of the present study was to compare in-hospital clinical outcomes between sufficient and insufficient diagonal flow in patients with anterior ST-elevation acute myocardial infarction. A total of 229 left anterior descending artery (LAD)-AMI with final Thrombolysis in Myocardial Infarction (TIMI)-3 LAD flow were included, and divided into the sufficient diagonal flow group (TIMI-3 diagonal flow: n = 170) and the insufficient diagonal flow group (TIMI ≤ 2 diagonal flow: n = 59)...
January 18, 2019: Heart and Vessels
Yoichiro Otaki, Tetsu Watanabe, Naohito Sato, Toru Shirata, Hayato Tsuchiya, Masahiro Wanezaki, Harutoshi Tamura, Satoshi Nishiyama, Takanori Arimoto, Hiroki Takahashi, Tetsuro Shishido, Keita Morikane, Masafumi Watanabe
Despite many recent advances in medicine, cardiogenic stroke is still a health problem with a high mortality rate. Cardiac biomarkers have been reported to be useful indicators for cardiogenic stroke and subsequent cerebrovascular events. However, there are no data directly comparing the cardiac biomarkers in stroke patients. We measured atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), N-terminal pro-brain natriuretic peptide (NT-proBNP), and high-sensitivity troponin T (hsTnT) levels and performed transthoracic and transesophageal echocardiography in 282 stroke patients...
January 17, 2019: Heart and Vessels
Tom Finck, Albrecht Will, Eva Hendrich, Stefan Martinoff, Martin Hadamitzky
Objectives of the study were to examine the long-term prognostic power of coronary computed tomography angiography (CCTA) to predict death or myocardial infarction in patients with diabetes mellitus (DM). The prognostic value of CCTA in diabetic patients has been confirmed for short- and intermediate follow-up durations. The slowly progressing nature of coronary artery disease (CAD), however, underlines the necessity to validate CCTA for longer observation periods in this high-risk population. A total of 132 patients with DM and 1781 without DM were examined by CCTA and followed for a median duration of 9...
January 11, 2019: Heart and Vessels
Masakazu Yamagishi, Toyonobu Tsuda, Takeshi Kato, Hiroshi Furusho, Kenshi Hayashi
Although benefits of direct oral anticoagulants (DOAC) for treatment of non-valvular atrial fibrillation (AF) were well demonstrated, few data exist regarding cost-effectiveness between DOAC and warfarin uses in real-world clinical practice. Therefore, we estimated total cost of treatment for AF by authorized cardiologists in Japan. We studied consecutive 617 anticoagulated non-valvular AF patients (418 men, mean age 68.8, 54% warfarin) consulted by authorized cardiologists. The mean time in therapeutic range of warfarin was 71...
January 5, 2019: Heart and Vessels
Hideo Amano, Ryota Noike, Daiga Saito, Takayuki Yabe, Ippei Watanabe, Ryo Okubo, Masayuki Koizumi, Mikihito Toda, Takanori Ikeda
Irregular protrusion on optical coherence tomography (OCT) is associated with clinical events and target lesion revascularization. We investigated clinical and procedure characteristics, plaque characteristics, slow flow after stent implantation, and clinical outcomes with irregular protrusion using OCT. Eighty-four lesions in 76 patients undergoing OCT before percutaneous coronary intervention were evaluated. Irregular protrusion was defined as protrusion of material with an irregular surface into the lumen between stent struts with a maximum height of ≥100 μm...
January 4, 2019: Heart and Vessels
Wenbo Yang, Yanxin Han, Chendie Yang, Yanjia Chen, Weilin Zhao, Xiuxiu Su, Ke Yang, Wei Jin
Ischaemia induces cardiac apoptosis and leads to a loss of cardiac function and heart failure after myocardial infarction. MicroRNA-19b-1 (miR-19b-1), a key member of the miR-17/92 cluster, plays crucial roles in inhibiting apoptosis. However, the role of miR-19b-1 in ischaemia-induced heart failure remains unknown. In this study, ischaemia resulted in cardiac apoptosis and the suppression of miR-19b-1 expression, whereas miR-19b-1 overexpression inhibited ischaemia-induced cardiac apoptosis in vivo and in vitro...
January 3, 2019: Heart and Vessels
Eiji Shigemoto, Atsushi Iwata, Makito Futami, Yuta Kato, Motoki Yamashita, Satoshi Imaizumi, Takashi Kuwano, Amane Ike, Makoto Sugihara, Keijiro Saku, Shin-Ichiro Miura
Chronic kidney disease (CKD) is well known to be associated with an increased incidence of coronary artery disease (CAD). Diabetes mellitus (DM) and hypertension (HTN), both of which are traditional risk factors for CAD, are the two most common causes of CKD. However, the influence of CKD on coronary atherosclerosis in CAD patients who have both DM and HTN remains uncertain. In these patients, we examined the relationship between CKD and coronary plaque using integrated backscatter intravascular ultrasound (IB IVUS)...
January 3, 2019: Heart and Vessels
Shozo Kaneko, Hiroshige Yamabe, Tadashi Hoshiyama, Hisanori Kanazawa, Miwa Ito, Yusuke Kanemaru, Takuya Kiyama, Kenichi Tsujita
It remains unclear whether AF is maintained by rotor. We evaluated the significance of rotor during atrial fibrillation (AF). Prevalence, location, and stability of rotational reentry (RR) in the left atrium were clarified by endocardial non-contact mapping in 66 AF patients. RR was classified into three categories: RR continued at stable site (Stable-RR), RR observed intermittently at the same site (Intermittent-RR), and RR observed at different locations (Different-RR). Catheter ablation was performed in a stepwise fashion (linear roof lesion and complex fractionated atrial electrogram ablation following pulmonary vein isolation) until AF termination and elucidated the consequence of radiofrequency lesion delivered within RR site on AF termination and recurrence...
January 3, 2019: Heart and Vessels
Gerrit Frommeyer, Dietrich Andresen, Hüseyin Ince, Sebastian Maier, Christoph Stellbrink, Thomas Kleemann, Karlheinz Seidl, Ellen Hoffmann, Bernhard Zrenner, Matthias Hochadel, Jochen Senges, Lars Eckardt
According to current guidelines prophylactic implantable cardioverter-defibrillator (ICD) therapy is recommended in patients with significantly impaired left ventricular systolic function. However, the recently published DANISH trial did not find a significantly lower long-term rate of death from any cause compared with usual clinical care in patients with non-ischemic cardiomyopathy. We investigated whether registry data from a multi-center 'real-life' registry on patients with non-ischemic cardiomyopathy are similar to this trial...
January 3, 2019: Heart and Vessels
Xiaojia Zhang, Deqing Chen, Jiaqi Wang, Jinding Liu, Hualin Guo, Gengqian Zhang
It has been demonstrated that S1P receptors affect heart ischaemia-reperfusion (IR) induced injury. However, whether S1P receptors affect IR-induced cardiac death has not been investigated. The aim of this paper is to demonstrate the role of S1P receptors in IR-induced cardiac death. Healthy adult male Sprague-Dawley rats were assigned to the following groups: non-operation control group, sham operation group, IR group, IR group pretreated with DMSO, IR group pretreated with S1P3 agonist, IR group pretreated with an antagonist of S1P3, IR group pretreated with S1P2 and S1P3 antagonists, IR group pretreated with heptanol and antagonists of S1P2/3, and IR group pretreated with Gap26 and antagonists of S1P2/3 (heptanol acts as a Cx43 uncoupler and the mimic peptide Gap26 as Cx43 blocker)...
January 2, 2019: Heart and Vessels
Satoshi Kurisu, Kazuhiro Nitta, Yoji Sumimoto, Hiroki Ikenaga, Ken Ishibashi, Yukihiro Fukuda, Yasuki Kihara
The frontal QRS-T angle is one of the markers of ventricular repolarization. We sought to assess the effects of myocardial perfusion defect on QRS-T angle in patients with prior anterior myocardial infarction (MI). Seventy-one patients with prior anterior MI and 71 age- and sex-matched control subjects having no myocardial perfusion defect were selected. Frontal QRS-T angle was defined as the absolute value of the difference between the frontal plane QRS axis and T-wave axis. The extent of myocardial perfusion defect was determined using myocardial perfusion single-photon emission computed tomography (SPECT)...
January 2, 2019: Heart and Vessels
Shinji Nemoto, Yusuke Kasahara, Kazuhiro P Izawa, Satoshi Watanabe, Kazuya Yoshizawa, Naoya Takeichi, Kentaro Kamiya, Norio Suzuki, Kazuto Omiya, Atsuhiko Matsunaga, Yoshihiro J Akashi
Resting heart rate (HR) plus 20 or 30 beats per minute (bpm), i.e., a simplified substitute for HR at the anaerobic threshold (AT), is used as a tool for exercise prescription without cardiopulmonary exercise testing data. While resting HR plus 20 bpm is recommended for patients undergoing beta-blocker therapy, the effects of specific beta blockers on HR response to exercise up to the AT (ΔAT HR) in patients with subacute myocardial infarction (MI) are unclear. This study examined whether carvedilol treatment affects ΔAT HR in subacute MI patients...
January 2, 2019: Heart and Vessels
Rikuta Hamaya, Tomoki Horie, Taishi Yonetsu, Akinori Sugano, Yoshihisa Kanaji, Eisuke Usui, Masahiro Hoshino, Masao Yamaguchi, Hiroaki Ohya, Yohei Sumino, Masahiro Hada, Hidenori Hirano, Yoshinori Kanno, Haruhito Yuki, Kenzo Hirao, Tsunekazu Kakuta
Baseline cardiac troponin is a strong predictor of major adverse cardiac events (MACE), and the high sensitive assay can provide risk stratification under the 99th percentile values. Currently, prognostic benefit of PCI has not been established in patients with stable coronary artery disease (CAD), and the influence on baseline troponin levels is unknown. This study aimed to investigate the impact of PCI on baseline high-sensitivity cardiac troponin-I (hs-cTnI) levels and the association with MACE incidence...
January 1, 2019: Heart and Vessels
Shinnosuke Kikuchi, Kengo Tsukahara, Kentaro Sakamaki, Yukiko Morita, Takeshi Takamura, Kazuki Fukui, Tsutomu Endo, Makoto Shimizu, Reimin Sawada, Teruyasu Sugano, Hideo Himeno, Syunichi Kobayashi, Kentaro Arakawa, Yasuyuki Mochida, Takashi Tsunematsu, Tomohiko Shigemasa, Jun Okuda, Toshiyuki Ishikawa, Kazuo Kimura, Kouichi Tamura
Some experimental studies have shown that direct oral anticoagulants (DOACs) have anti-inflammatory effects. However, the interval changes in inflammatory markers in patients with non-valvular atrial fibrillation (AF) who receive DOACs remain unknown. Between July 2013 and April 2014, a total of 187 AF patients randomly assigned to receive rivaroxaban (n = 91) or dabigatran (n = 96) were assessed for eligibility. The levels of the following inflammatory markers were serially evaluated: high-sensitivity C-reactive protein, pentraxin-3, interleukin (IL)-1β, IL-6, IL-18, tumor necrosis factor-α, monocyte chemotactic protein-1, growth and differentiation factor-15, and soluble thrombomodulin (sTM)...
January 1, 2019: Heart and Vessels
Susumu Ibe, Yoshimi Kishimoto, Hanako Niki, Emi Saita, Tomohiko Umei, Kotaro Miura, Yukinori Ikegami, Reiko Ohmori, Kazuo Kondo, Yukihiko Momiyama
Nesfatin-1 is a recently identified anorexigenic peptide mainly secreted from the brain and adipose tissue. Although nesfatin-1 may have pro-inflammatory and apoptotic properties, the association between plasma nesfatin-1 levels and coronary artery disease (CAD) has not been clarified yet. We investigated plasma nesfatin-1 levels in 302 patients undergoing elective coronary angiography. Of the 302 study patients, CAD was present in 172 (57%), of whom 67 had 1-vessel, 49 had 2-vessel, and 56 had 3-vessel disease...
January 1, 2019: Heart and Vessels
Fang-Zhou Liu, Wei-Dong Lin, Hong-Tao Liao, Jian Peng, Yu-Mei Xue, Xian-Zhang Zhan, Jie-Ming Zhu, Kai-Hang Yiu, Yi-Fu Li, Hung-Fat Tse, Li Shi, Xian-Hong Fang, Shu-Lin Wu
To investigate the safety and midterm outcome of concomitant left atrial appendage (LAA) closure and catheter ablation (CA) as a one-stage hybrid procedure for non-valvular atrial fibrillation (AF) in a multicenter registry. A total of 50 consecutive patients with symptomatic drug-resistant non-valvular AF with CHA2 DS2 -VASc score ≥ 2 and contraindications for antithrombotic therapy were included in the prospectively established LAA closure registry, and underwent concomitant LAA closure (48 for WATCHMAN and 2 for ACP) and CA procedure (40 for radiofrequency and 10 for cryoballoon CA)...
January 1, 2019: Heart and Vessels
Fukuko Nagura, Akihisa Kataoka, Masahiko Hara, Ken Kozuma, Yusuke Watanabe, Makoto Nakashima, Hirofumi Hioki, Hideyuki Kawashima, Yugo Nara, Shinichi Shirai, Norio Tada, Motoharu Araki, Toru Naganuma, Futoshi Yamanaka, Hiroshi Ueno, Minoru Tabata, Kazuki Mizutani, Akihiro Higashimori, Kensuke Takagi, Masanori Yamamoto, Kentaro Hayashida
Pre-procedural valvuloarterial impedance (Zva) is considered as a useful predictor of mortality in patients diagnosed as having severe aortic stenosis (AS) who undergo transcatheter aortic valve implantation (TAVI). However, the prognostic significance of post-procedural Zva remains unclear. We aimed to evaluate the prognostic significance of Zva after TAVI. We retrospectively analyzed the clinical and echocardiographic data of 1004 consecutive elderly patients (median 84 years old, 27.5% men) who underwent TAVI for severe symptomatic AS...
January 1, 2019: Heart and Vessels
Takayoshi Toba, Toshiro Shinke, Hiromasa Otake, Yoichiro Sugizaki, Ryo Takeshige, Hiroyuki Onishi, Akira Nagasawa, Yoshiro Tsukiyama, Kenichi Yanaka, Yuichiro Nagano, Hiroyuki Yamamoto, Hiroyuki Kawamori, Akira Matsuura, Takayuki Ishihara, Daisuke Matsumoto, Nobuaki Igarashi, Takatoshi Hayashi, Yoshinori Yasaka, Makoto Kadotani, Takashi Fujii, Junya Shite, Masaharu Okada, Takashi Sakakibara, Ken-Ichi Hirata
The impact of dual antiplatelet therapy (DAPT) with adjusted-dose (3.75 mg/day) prasugrel for Japanese patients has not been fully investigated in terms of local arterial healing following the elective percutaneous coronary intervention (PCI). The ROUTE-01 elective study was a prospective, 12-center and single-arm registry that enrolled 123 patients who underwent elective PCI with everolimus-eluting stents (EESs) under DAPT with a combination of adjusted-dose prasugrel and aspirin. Serial optical coherence tomography (OCT) was performed at the index PCI and 9-month follow-up to assess the relationship between in-stent thorombus (IST) and residual platelet reactivity measuring platelet reactivity unit (PRU)...
January 1, 2019: Heart and Vessels
Yu Dong, Yan Bai, Shangyue Zhang, Wenli Xu, Jiahui Xu, Yi Zhou, Suli Zhang, Ye Wu, Haicun Yu, Ning Cao, Huirong Liu, Wen Wang
Autoantibodies against the second extracellular loop of β1 -adrenergic receptor (β1 -AA) have been shown to be involved in the development of cardiovascular diseases. Recently, there has been considerable interest in strategies to remove these autoantibodies, particularly therapeutic peptides to neutralize β1 -AA. Researchers are investigating the roles of cyclic peptides that mimic the structure of relevant epitopes on the β1 -AR-ECII in a number of immune-mediated diseases. Here, we used a cyclic peptide, namely, RD808, to neutralize β1 -AA, consequently alleviating β1 -AA-induced myocardial injury...
December 15, 2018: Heart and Vessels
Taro Kamada, Masamichi Iwasaki, Akihide Konishi, Toshiro Shinke, Hiroshi Okamoto, Takatoshi Hayashi, Ken-Ichi Hirata
Platelet reactivity in the presence of clopidogrel is deteriorated in patients undergoing hemodialysis (HD). However, the impact of residual platelet reactivity with prasugrel use in Japanese patients on HD remains unclear. This was a prospective, multi-center, single-arm study conducted to compare platelet reactivity of prasugrel 3.75 mg per day vs. clopidogrel 75 mg per day in patients on chronic HD. We assessed P2Y12 reaction units (PRU) using the VerifyNow® P2Y12 test for all enrolled patients at baseline (clopidogrel treatment) and at 14 days (prasugrel treatment) pre- and post-HD...
December 12, 2018: Heart and Vessels
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"