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Heart and Vessels

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https://www.readbyqxmd.com/read/29051976/late-gadolinium-enhancement-on-cardiac-magnetic-resonance-imaging-is-associated-with-coronary-endothelial-dysfunction-in-patients-with-dilated-cardiomyopathy
#1
Mina Nakayama, Megumi Yamamuro, Seiji Takashio, Tomoaki Uemura, Naoki Nakayama, Kyoko Hirakawa, Seitaro Oda, Daisuke Utsunomiya, Koichi Kaikita, Seiji Hokimoto, Yasuyuki Yamashita, Yukiko Morita, Kazuo Kimura, Kouichi Tamura, Kenichi Tsujita
Myocardial fibrosis and coronary endothelial dysfunction are important determinants of outcome in patients with heart failure. However, the relationship of these factors in patients with dilated cardiomyopathy (DCM) is not fully understood. This study aimed to investigate the relationship between endothelium-dependent coronary vasomotor abnormality and late gadolinium enhancement (LGE) on cardiac magnetic resonance imaging (CMR) in patients with DCM. We examined 38 consecutive patients with DCM. All patients underwent CMR and the acetylcholine (ACh) provocation test using cardiac catheterization...
October 19, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/29051975/impact-of-lesion-complexity-on-long-term-vascular-response-to-cobalt-chromium-everolimus-eluting-stent-five-year-follow-up-optical-coherence-tomography-study
#2
Shoichi Kuramitsu, Shinjo Sonoda, Tomohiro Shinozaki, Hiroyuki Jinnouch, Yoshitaka Muraoka, Takenori Domei, Makoto Hyodo, Shinichi Shirai, Kenji Ando, Yutaka Otsuji
The impact of lesion complexity on long-term vascular response to cobalt-chromium everolimus-eluting stent (CoCrEES) remains unclear. We sought to evaluate them using optical coherence tomography (OCT). A total of 47 patients with 58 lesions treated only with CoCrEES and no target-vessel events within 5 years after implantation were prospectively enrolled and underwent 5-year follow-up OCT. Quantitative parameters and qualitative characteristics of the neointima were evaluated using multilevel logistic or linear regression models with random effects at three levels: lesion, cross-section (CS), and strut...
October 19, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/29032492/stent-unzipping-using-an-ultra-high-pressure-balloon-in-vitro-and-animal-experiments
#3
Kazuto Fujimoto, Takanari Fujii, Yoshihito Hata, Suguru Tarui, Yoshinori Miyahara, Kozo Ishino, Hideshi Tomita
As a child grows, limitations to the maximum dilatable stent diameter (MDD) will result in stenosis associated with size mismatch. If an implanted stent can be intentionally fractured along its length, a process called "unzipping," it may eventually be redilated to adult vessel size. Few studies have addressed how a stent can be unzipped using an ultra-high-pressure balloon (UHB) with the smallest balloon diameter. Eleven commercially available stents, three Liberté stents (LS), six genesis renal stents (GS), and two express vascular SD stents (ES), were tested for in vitro unzipping...
October 14, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/29030709/bleeding-risk-of-submuscular-icd-implantation-with-continued-oral-anticoagulation-versus-heparin-bridging-therapy
#4
Simon Pecha, Ayhan Ayikli, Iris Wilke, Samer Hakmi, Yalin Yildirim, Nils Gosau, Hermann Reichenspurner, Stephan Willems, Muhammet Ali Aydin
Recent studies have shown that subcutaneous or subfascial pacemaker- and ICD implantation with continued oral anticoagulation therapy is associated with lower risk for bleeding complications, when compared to heparin bridging strategies. However, ICD generators are often implanted submuscularly. We therefore compared the bleeding risk with continued phenprocoumon therapy vs. heparin bridging in patients receiving submuscular ICD implantation. Between 01/2013 and 12/2013, 104 patients with need for oral anticoagulation received submuscular ICD or CRT-D implantation in our institution...
October 13, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/29027587/correlation-between-endothelial-dysfunction-and-myocardial-damage-in-acute-phase-of-tako-tsubo-cardiomyopathy-brachial-flow-mediated-dilation-as-a-potential-marker-for-assessment-of-patient-with-tako-tsubo
#5
Rosa Carbonara, Francesco Giardinelli, Martino Pepe, Giovanni Luzzi, Immacolata Panettieri, Vito Vulpis, Alessandro Santo Bortone, Marco Matteo Ciccone
Takotsubo cardiomyopathy (TTC) is characterized by transient systolic ventricular dysfunction. It is supposed to be caused by a cathecolaminergic wave which leads to myocardial stunning through a massive action on beta2-adrenoreceptor. Moreover, beta2-receptor hyperactivity negatively influences endothelial function. It can be detected by brachial flow mediated dilation (b-FMD) which assesses endothelium regulated vasomotility. The study aim is to analyze the b-FMD variability during hospitalization in 50 patients admitted with TTC...
October 13, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/29027577/assessment-of-renal-perfusion-impairment-in-a-rat-model-of-acute-renal-congestion-using-contrast-enhanced-ultrasonography
#6
Kaoru Komuro, Yoshihiro Seo, Masayoshi Yamamoto, Seika Sai, Tomoko Ishizu, Kyo Shimazu, Yumi Takahashi, Shogo Imagawa, Teisuke Anzai, Kazuya Yonezawa, Kazutaka Aonuma
Renal congestion is caused by elevated central venous pressure (CVP), and decreases glomerular filtration in patients with congestive heart failure. Since real-time contrast-enhanced ultrasonography (CEUS) using microbubble-based contrast agents can visualize the perfused microvascular bed, we sought to evaluate the impairment of renal perfusion during acute renal congestion with CEUS. In Wister rats, CEUS of kidney was performed with the direct monitoring of CVP and intra-renal pressure (IRP). When CVP was elevated to 10 and 15 mmHg after the bolus injection of normal saline via the femoral vein, peak intensity (PI, dB) and time to PI (TTP) in the renal cortex and medulla were compared with control rats...
October 13, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/29026988/pulmonary-annular-motion-velocity-reflects-right-ventricular-outflow-tract-function-in-children-with-surgically-repaired-congenital-heart-disease
#7
Yasunobu Hayabuchi, Akemi Ono, Yukako Homma, Shoji Kagami
Right ventricular (RV) dysfunction is generally evaluated using analyses of tricuspid annular motion. However, it represents only one aspect of RV performance. Whether measuring pulmonary annular motion velocity could serve as a novel way to evaluate global RV and/or RV outflow tract (RVOT) performance in pediatric congenital heart disease (CHD) patients with surgically repaired RVOT was evaluated. In this prospective study, tissue Doppler-derived pulmonary annular motion velocity was measured in children (aged 2-5 years) with RVOT reconstruction (RVOTR group, n = 48) and age-matched healthy children (Control, n = 60)...
October 12, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/28975447/tumor-necrosis-factor-alpha-stimulated-gene-6-tsg-6-inhibits-the-inflammatory-response-by-inhibiting-the-activation-of-p38-and-jnk-signaling-pathway-and-decreases-the-restenosis-of-vein-grafts-in-rats
#8
Chengxin Zhang, Biao Zhang, Huiping Wang, Qianshan Tao, Shenglin Ge, Zhimin Zhai
This study aims to explore the effects of tumor necrosis factor alpha-stimulated gene-6 (TSG-6) on vascular inflammatory response and vascular injury in grafted vein wall of rats and its possible mechanism. Vascular grafting model was established by modified cuff. The effect of TSG-6 on the inflammatory response and vascular injury of vein graft was investigated. The activation of mast cells and macrophages after LPS stimulation was observed by lentivirus-mediated upregulation or downregulation of TSG-6 expression...
October 3, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/28975398/pulse-wave-travel-distance-as-a-novel-marker-of-ventricular-arterial-coupling
#9
Yurie Obata, Pavel Ruzankin, Allan Gottschalk, Daniel Nyhan, Dan E Berkowitz, Jochen Steppan, Viachaslau Barodka
Each stroke volume ejected by the heart is distributed along the arterial system as a pressure waveform. How far the front of the pressure waveform travels within the arterial system depends both on the pulse wave velocity (PWV) and the ejection time (ET). We tested the hypothesis that ET and PWV are coupled together, in order to produce a pulse wave travel distance (PWTD = PWV × ET) which would match the distance from the heart to the most distant site in the arterial system. The study was conducted in 11 healthy volunteers...
October 3, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/28975394/plasma-l-arginine-levels-distinguish-pulmonary-arterial-hypertension-from-left-ventricular-systolic-dysfunction
#10
Anna Sandqvist, Jörn Schneede, David Kylhammar, Dan Henrohn, Jakob Lundgren, Mikael Hedeland, Ulf Bondesson, Göran Rådegran, Gerhard Wikström
Pulmonary arterial hypertension (PAH) is a life-threatening condition, characterized by an imbalance of vasoactive substances and remodeling of pulmonary vasculature. Nitric oxide, formed from L-arginine, is essential for homeostasis and smooth muscle cell relaxation in PAH. Our aim was to compare plasma concentrations of L-arginine, asymmetric dimethylarginine (ADMA), and symmetric dimethylarginine (SDMA) in PAH compared to left ventricular systolic dysfunction (LVSD) and healthy subjects. This was an observational, multicenter study comparing 21 patients with PAH to 14 patients with LVSD and 27 healthy subjects...
October 3, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/28965202/interleukin-6-downregulated-vascular-smooth-muscle-cell-contractile-proteins-via-atg4b-mediated-autophagy-in-thoracic-aortic-dissection
#11
Zhao An, Fan Qiao, Qijue Lu, Ye Ma, Yang Liu, Fanglin Lu, Zhiyun Xu
Interleukin-6 (IL-6) overexpression played an important role in the pathogenesis of thoracic aortic dissection (TAD). Our previous study found enhanced autophagy accompanying with contractile proteins α smooth muscle actin (α-SMA) and smooth muscle 22α (SM22α) degradation in TAD aortic vascular smooth muscle cells (VSMCs). Autophagy is an important way for intracellular proteins degradation, while IL-6 has been found as a contributing factor of autophagy in some cancers. These indicated IL-6 might contribute to the occurrence of TAD by promoting autophagy-induced contractile proteins degradation, which has not been investigated...
September 30, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/28965152/high-incidence-of-progressive-stenosis-in-aberrant-left-subclavian-artery-with-right-aortic-arch
#12
Mamoru Muraoka, Hazumu Nagata, Yuichiro Hirata, Kiyoshi Uike, Eiko Terashi, Eiji Morihana, Masayuki Ochiai, Yasuyuki Fujita, Kiyoko Kato, Kenichiro Yamamura, Shouichi Ohga
Right aortic arch with aberrant left subclavian artery (RAA/aLSCA) is a rare aortic arch anomaly. The clinical association of aLSCA stenosis with RAA/aLSCA has not yet been fully elucidated. The aim of this study was to investigate the diagnosis, incidence, management and outcome of aLSCA stenosis in infants with prenatally diagnosed RAA/aLSCA. Ten fetuses who were diagnosed as having RAA/aLSCA in Kyushu University Hospital between January 2011 and December 2014 were enrolled. The maternal and child medical records were reviewed to investigate sex, gestational age at the fetal diagnosis, gestational age and body weight at birth, the findings of computed tomography (CT), Doppler ultrasonography of the vertebral artery and angiography, and the complications and outcomes of aLSCA stenosis...
September 30, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/28965135/chronic-phase-improvements-in-electrocardiographic-and-echocardiographic-manifestations-of-left-ventricular-hypertrophy-after-alcohol-septal-ablation-for-drug-refractory-hypertrophic-obstructive-cardiomyopathy
#13
Junya Matsuda, Mitsunobu Kitamura, Morimasa Takayama, Yoichi Imori, Junsuke Shibuya, Yoshiaki Kubota, Hideto Sangen, Shunichi Nakamura, Hitoshi Takano, Kuniya Asai, Wataru Shimizu
After alcohol septal ablation (ASA), regression of left ventricular hypertrophy (LVH) has been observed in several studies using echocardiography or cardiac magnetic resonance, and favorable changes of myocardial excitation have been expected. However, no studies have focused on the alteration of electrocardiography (ECG) findings after ASA. Therefore, we evaluated serial changes in ECG parameters during the chronic phase after ASA for drug-refractory hypertrophic obstructive cardiomyopathy (HOCM). From 1998 to 2014, we performed 187 ASA procedures in 157 drug-refractory HOCM patients...
September 30, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/28956134/prognostic-benefit-of-maintaining-the-hemoglobin-level-during-the-acute-phase-in-patients-with-severely-decompensated-acute-heart-failure
#14
Akihiro Shirakabe, Noritake Hata, Nobuaki Kobayashi, Hirotake Okazaki, Masato Matsushita, Yusaku Shibata, Suguru Nishigoori, Saori Uchiyama, Kuniya Asai, Wataru Shimizu
The optimum method of managing anemia during the acute phase of acute heart failure (AHF) remains to be elucidated. The data from 1109 AHF patients were enrolled in present study. The hemoglobin (Hb) levels were evaluated in all patients at admission (day 1) and 3 days after admission (day 3), and in survival discharge patients (n = 998) before discharge (pre-discharge). The serum hemoglobin levels were significantly lower on day 3 (11.2 (9.6-12.9) g/dl) than on day 1 (12.4 (10.4-14.2) g/dl) and at pre-discharge (11...
September 27, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/28952029/impact-of-simple-electrocardiographic-markers-as-predictors-for-deterioration-of-left-ventricular-function-in-patients-with-frequent-right-ventricular-apical-pacing
#15
Yusuke Hayashi, Masahiko Takagi, Jun Kakihara, Shogo Sakamoto, Hiroaki Tatsumi, Atsushi Doi, Shinichi Iwata, Kenichi Sugioka, Minoru Yoshiyama
Several trials demonstrated that frequent right ventricular apical pacing (RVAP) was associated with cardiac dysfunction and an increased rate of heart failure hospitalization. However, there are few reports about the 12-lead electrocardiogram (12-ECG) parameters at the time of device implantation to predict deterioration of LVEF in patients with frequent RVAP. We retrospectively studied 115 consecutive patients undergoing pacemaker or implantable cardioverter-defibrillator implantation with RVAP, with rate of ventricular pacing ≥ 40% and LVEF ≥ 50% at the time of implantation...
September 26, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/28939932/prognostic-value-of-selected-echocardiographic-impedance-cardiographic-and-hemodynamic-parameters-determined-during-right-heart-catheterization-in-patients-qualified-for-heart-transplantation
#16
Wojciech Gilewski, Jarosław Pietrzak, Joanna Banach, Robert Bujak, Jan Błażejewski, Danuta Karasek, Łukasz Wołowiec, Władysław Sinkiewicz
The aim of the study was to verify prognostic value of selected echocardiographic (UKG), impedance cardiography (ICG), and right heart catheterization (RHC) parameters in systolic heart failure (HF). UKG, ICG, and RHC were performed in 46 patients with chronic HF with ejection fraction <35%. During a 1-year follow-up, composite endpoint (death or hospitalization due to HF exacerbation) was achieved by 23 (50.0%) patients. Analysis of receiver operating characteristic (ROC) curves identified UKG parameters: inferior vena cava diameter on inspiration (IVCinsp) >13 mm [area under curve (AUC), 0...
September 22, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/28905211/three-nights-leg-thermal-therapy-could-improve-sleep-quality-in-patients-with-chronic-heart-failure
#17
Hiroyuki Sawatari, Mari K Nishizaka, Mami Miyazono, Shin-Ichi Ando, Shujiro Inoue, Masao Takemoto, Takafumi Sakamoto, Daisuke Goto, Tomoo Furumoto, Shintaro Kinugawa, Nobuko Hashiguchi, Anita Rahmawati, Hiroaki Chishaki, Tomoko Ohkusa, Chie Magota, Hiroyuki Tsutsui, Akiko Chishaki
Sleep quality is often impaired in patients with chronic heart failure (HF), which may worsen their quality of life and even prognosis. Leg thermal therapy (LTT), topical leg warming, has been shown to improve endothelial function, oxidative stress, and cardiac function in patients with HF. However, its short-term influence to sleep quality has not been evaluated in HF patients. Eighteen of 23 patients with stable HF received LTT (15 min of warming at 45 °C and 30 min of insulation) at bedtime for 3 consecutive nights and 5 patients served as control...
September 13, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/28905210/impact-of-pharmacological-spasm-provocation-test-in-patients-with-a-history-of-syncope
#18
Shozo Sueda, Hiroaki Kohno
Coronary artery spasm is involved in the pathogenesis of various cardiac disorders. We investigated patients with a history of syncope who underwent elective coronary angiography. We retrospectively analyzed 5781 consecutive patients who had diagnostic or follow-up angiography during a 26-year period. During this period, we found 95 patients with a history of syncope before elective coronary angiography. Pharmacological spasm provocation testing was performed in 64 patients with a history of syncope (<1 year)...
September 13, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/28889231/favorable-effects-of-early-tolvaptan-administration-in-very-elderly-patients-after-repeat-hospitalizations-for-acute-decompensated-heart-failure
#19
Masaki Kinoshita, Hideki Okayama, Tetsuya Kosaki, Saki Hosokawa, Go Kawamura, Tatsuya Shigematsu, Tatsunori Takahashi, Yoshitaka Kawada, Go Hiasa, Tadakatsu Yamada, Hiroshi Matsuoka, Yukio Kazatani
Tolvaptan (TLV) is an oral selective vasopressin 2 receptor antagonist that acts on the distal nephrons, causing a loss of electrolyte-free water. To date, its early administration in very elderly patients after repeat hospitalizations for acute decompensated heart failure (ADHF) despite receiving optimal medical therapy has not been evaluated. Fifty-six ADHF patients who were >80 years old and had been repeatedly hospitalized were retrospectively enrolled in this study. Twenty-five patients (14 men; mean age 86...
September 9, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/28889210/ketamine-and-midazolam-differently-impact-post-intubation-hemodynamic-profile-when-used-as-induction-agents-during-emergency-airway-management-in-hemodynamically-stable-patients-with-st-elevation-myocardial-infarction
#20
Marco Zuin, Gianluca Rigatelli, Fabio Dell'Avvocata, Giuseppe Faggian, Luca Conte, Sara Giatti, Flavio Michielan, Loris Roncon
We investigated the incidence of post-intubation hypotension (PIH) in hemodynamically stable patients with STEMI requiring rapid sequences intubation (RSI) and medicated with ketamine or midazolam as induction agent. STEMI patients admitted between 1st January 2009 and 1st January 2017 who did not receive any type of inotropic support before the endotracheal intubation (ETI) was reviewed. PIH was defined as a reduction greater than 20% or a drop of systolic blood pressure (SBP) below 90 mmHg within 10 min from the administration of the induction agent [ketamine (1 mg/kg) or midazolam (0...
September 9, 2017: Heart and Vessels
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