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Heart and Vessels

Baptiste Maille, Linda Koutbi, Noémie Resseguier, Coralie Lemoine, Franck Thuny, Michael Peyrol, Jérôme Hourdain, Jean-Claude Deharo, Frédéric Franceschi
Infections of cardiac implantable electronic devices (CIEDs) have increased over the past decade. However, the impact of the climate on CIED infections is unknown. To determine whether there is a seasonal variation in CIED infections. In this single-center observational study, retrospective analysis of prospectively collected data was performed. Timone Hospital in Marseille (south-east France) is a tertiary care institution and the regional reference center for management of CIED infections. All consecutive patients with CIED extractions for infectious reasons were included over a 12-year period...
November 10, 2018: Heart and Vessels
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November 10, 2018: Heart and Vessels
Satoshi Imaizumi, Yuhei Shiga, Masahiro Ogawa, Hideto Sako, Yoshihisa Nagata, Akira Matsunaga, Tetsuro Shirotani, Fumihiro Hoshino, Eiji Yahiro, Yuko Uehara, Natsumi Morito, Hiroyuki Tanigawa, Dai Shimono, Mikio Fukushima, Hidekazu Sugihara, Kenji Norimatsu, Takaaki Kusumoto, Keijiro Saku, Shin-Ichiro Miura
There is a lack of data on how to treat hypertensive patients with diabetes when treatment with medium doses of calcium channel blocker and angiotensin II type 1 receptor blocker (ARB) is insufficient to achieve the target blood pressure (BP). A total of 121 participants with type 2 diabetes and uncontrolled essential hypertension, who were receiving medium doses of amlodipine (5 mg/day) and ARB, were enrolled. Participants were randomized to receive either a high dose of amlodipine (10 mg/day) plus a medium dose of ARB (high-AML) or a medium dose of amlodipine (5 mg/day) plus a high dose of ARB (high-ARB)...
November 8, 2018: Heart and Vessels
Hideki Koike, Toshisuke Morita, Junko Tatebe, Ippei Watanabe, Makiko Koike, Shintaro Yao, Masaya Shinohara, Hitomi Yuzawa, Takeya Suzuki, Tadashi Fujino, Takanori Ikeda
Indoxyl sulfate (IS), a protein-bound uremic toxin, induces renal disorders and atrial fibrillation (AF). It is well known that renal dysfunction is a risk factor for AF and radiofrequency catheter ablation (RFCA) improves the renal function. However, the improvement in the renal function after RFCA in patients with early stage chronic kidney disease (CKD) and the serial changes in the IS level have not been fully elucidated. This study aimed to investigate whether IS affects the improvement in the renal function...
November 8, 2018: Heart and Vessels
Hideki Yano, Shigeo Horinaka, Manami Watahik, Tomoko Watanabe, Toshihiko Ishimitsu
Cobalt-chromium everolimus-eluting stent (CoCr EES) is associated with a lower rate of stent thrombosis even in patients with ST-elevation myocardial infarction (STEMI). However, the time-serial changes of endothelial coverage of the stent struts in the extremely early period have never been reported, especially in patients with STEMI. The aim of this study was to compare the vessel healing process between CoCr EES and cobalt-chromium bare metal stent (CoCr BMS) implantations using optical coherence tomography (OCT) in patients with STEMI...
November 3, 2018: Heart and Vessels
Hiroyuki Okura, Yoshihiko Saito, Tsunenari Soeda, Koichi Nakao, Yukio Ozaki, Kazuo Kimura, Junya Ako, Teruo Noguchi, Satoshi Yasuda, Satoru Suwa, Kazuteru Fujimoto, Yasuharu Nakama, Takashi Morita, Wataru Shimizu, Atsushi Hirohata, Yasuhiro Morita, Teruo Inoue, Atsunori Okamura, Masaaki Uematsu, Kazuhito Hirata, Kengo Tanabe, Yoshisato Shibata, Mafumi Owa, Kenichi Tsujita, Kunihiro Nishimura, Yoshihiro Miyamoto, Masaharu Ishihara
Previous studies have demonstrated that use of intravascular ultrasound (IVUS) during percutaneous coronary intervention (PCI) was associated with lower incidence of death, myocardial infarction, and target vessel revascularization. Recently, optical coherence tomography (OCT) has emerged as an alternative intravascular imaging device with better resolution. The aim of this study was to investigate frequency and prognostic impact of IVUS or OCT-guided PCI during urgent revascularization for acute myocardial infarction diagnosed by the universal definition...
November 2, 2018: Heart and Vessels
Hideyuki Kishima, Takanao Mine, Eiji Fukuhara, Kenki Ashida, Masaharu Ishihara, Tohru Masuyama
Thromboembolism and bleeding complications remain a major limitation of the catheter ablation (CA) for atrial fibrillation (AF). This study aimed to evaluate the association between achieving target activated clotting time (ACT) and clinical factors, and to develop an appropriate protocol for early achievement of target ACT in patients with direct oral anticoagulants (DOACs). At the initiation cohort, 190 patients (127 males, age 68 ± 9) taking DOACs who underwent CA for AF were studied. All patients underwent transthoracic echocardiography/transesophageal echocardiography/blood sampling before the CA...
November 2, 2018: Heart and Vessels
Yosuke Murase, Yasuya Inden, Hajime Imai, Seifuku Kyo, Satoshi Yanagisawa, Aya Fujii, Yusuke Sakamoto, Toshiro Tomomatsu, Toyoaki Murohara
Early recurrence of atrial arrhythmia (ERAA) after ablation frequently occurs, but there is limited evidence about ERAA-timing. This study aimed to investigate the association between ERAA-timing and late recurrence. We retrospectively investigated 332 patients who underwent PVI for paroxysmal atrial fibrillation at Nagoya University Hospital and Komaki City Hospital. Seventy-six patients (23%) had ERAA. The cutoff value of the first ERAA for late recurrence was set as 3 days, with a specificity of 77% and sensitivity of 43%...
November 2, 2018: Heart and Vessels
Lan Ma, Juan Wang, Li Li, Qi Qiao, Ruo-Min Di, Xiu-Mei Li, Ying-Jia Xu, Min Zhang, Ruo-Gu Li, Xing-Biao Qiu, Xun Li, Yi-Qing Yang
Congenital heart defect (CHD) is the most common form of birth deformity and is responsible for substantial morbidity and mortality in humans. Increasing evidence has convincingly demonstrated that genetic defects play a pivotal role in the pathogenesis of CHD. However, CHD is a genetically heterogeneous disorder and the genetic basis underpinning CHD in the vast majority of cases remains elusive. This study was sought to identify the pathogenic mutation in the ISL1 gene contributing to CHD. A cohort of 210 unrelated patients with CHD and a total of 256 unrelated healthy individuals used as controls were registered...
November 2, 2018: Heart and Vessels
Kenichiro Otsuka, Kenei Shimada, Hisashi Katayama, Haruo Nakamura, Hirotoshi Ishikawa, Hisateru Takeda, Kohei Fujimoto, Noriaki Kasayuki, Minoru Yoshiyama
Renal dysfunction and its change pattern are associated with short- and long-term mortality. However, it remains to be investigated whether or not worsening renal function (WRF) defined by baseline renal function identified from different time points would provide prognostic implication on outcomes in acute coronary syndrome (ACS) patients. This study consists of 334 ACS patients (mean age 68 ± 11 years, 75% male) treated with emergent percutaneous coronary intervention (PCI). Estimated glomerular filtration rate (eGFR) was evaluated on baseline, during hospitalization, at discharge, and at 3-month follow-up...
November 1, 2018: Heart and Vessels
Gaku Nakai, Daisuke Shimura, Ken Uesugi, Ichige Kajimura, Qibin Jiao, Yoichiro Kusakari, Tomoyoshi Soga, Nobuhito Goda, Susumu Minamisawa
Fatty acid (FA) oxidation is impaired and glycolysis is promoted in the damaged heart. However, the factor(s) in the early stages of myocardial metabolic impairment remain(s) unclear. C57B6 mice were subcutaneously administered monocrotaline (MCT) in doses of 0.3 mg/g body weight twice a week for 3 or 6 weeks. Right and left ventricles at 3 and 6 weeks after administration were subjected to capillary electrophoresis-mass spectrometry metabolomic analysis. We also examined mRNA and protein levels of key metabolic molecules...
November 1, 2018: Heart and Vessels
Koichiro Matsumura, Shun Morishita, Naoki Taniguchi, Kazuya Takehana, Hiroki Takahashi, Munemitsu Otagaki, Kei Yoshioka, Yoshihiro Yamamoto, Masahiko Takagi, Ichiro Shiojima
Inconsistent results have been reported concerning the effect of tolvaptan treatment on long-term prognostic outcomes in patients with acute decompensated heart failure (ADHF) and data are limited on prognostic factors affecting this patient population. We investigated prognostic factors influencing long-term clinical outcomes in patients with ADHF treated with tolvaptan in a real-world setting. A total of 263 consecutive patients hospitalized for ADHF and treated with tolvaptan were retrospectively enrolled...
November 1, 2018: Heart and Vessels
Sarasa Isobe, Yuji Itabashi, Takashi Kawakami, Masaharu Kataoka, Shun Kohsaka, Toshimitsu Tsugu, Mai Kimura, Mitsuaki Sawano, Toshiomi Katsuki, Takashi Kohno, Jin Endo, Mitsushige Murata, Keiichi Fukuda
Balloon pulmonary angioplasty (BPA) has emerged as an effective treatment for patients with inoperable chronic thromboembolic pulmonary hypertension (CTEPH). Renal function has been identified as a prognostic marker in patients with pulmonary hypertension in previous studies. We, therefore, aimed to investigate the clinical parameters associated with improvements in renal function in patients with CTEPH. A total of 45 consecutive patients with inoperable CTEPH undergoing BPA (mean age 62.2 ± 15.1 years) were included in the study...
November 1, 2018: Heart and Vessels
Yu Yoshida, Jun Maeda, Hiroyuki Fukushima, Natsuko Tokita, Hiroyuki Yamagishi, Mitsuaki Tokumura
Resting bradycardia is an important symptom for early diagnosis of anorexia nervosa (AN) during weight loss, and it improves with body-weight recovery. However, chronotropic incompetence (CI) in exercise is observed in some patients with AN despite amelioration of resting bradycardia in the recovery phase. We examined the relationship between CI in exercise and other parameters in patients with AN during the recovery phase. Ninety-two girls with AN (aged 13-20 years, median 15 years) performed cardiopulmonary exercise tolerance tests with a bicycle ergometer in the post-treatment recovery phase...
October 19, 2018: Heart and Vessels
Daisuke Sato, Satoshi Ikeda, Seiji Koga, Yuki Yamagata, Masamichi Eguchi, Tsuyoshi Yonekura, Akira Tsuneto, Tsuyoshi Yoshimuta, Yuji Koide, Hiroaki Kawano, Koji Maemura
Venous thromboembolism (VTE) is a multifactorial disease. Cancer and older age are risk factors for both recurrent VTE and bleeding under anticoagulant therapy. Oral direct factor Xa inhibitors (Xa inhibitors) have been widely used to treat VTE. However, their effectiveness and safety in cancer and elderly patients have not been fully elucidated. A total of 187 consecutive patients who started Xa inhibitors for VTE therapy between September 2014 and September 2016 were recruited. Patients' demographics, changes in VTE amount, VTE recurrence, clinically relevant bleeding, and death until February 2017 were compared between 92 cancer and 95 non-cancer patients, and 57 elderly (≥ 75 years) and 130 non-elderly patients...
October 19, 2018: Heart and Vessels
Satoshi Kawada, Atsuyuki Watanabe, Yoshimasa Morimoto, Koji Nakagawa, Nobuhiro Nishii, Kazufumi Nakamura, Hiroshi Morita, Hiroshi Ito
Atrial fibrillation (AF) frequently coexists with cardiovascular disease (CAD) in a clinical setting. However, the optimum therapy for AF patients who have concomitant CAD is unclear. We retrospectively examined the efficacy and safety of radiofrequency catheter ablation (RFCA) prior to percutaneous coronary intervention (PCI) in patients with AF who had concomitant stable CAD. Between January 2014 and December 2015, a total 264 patients (179 men; mean age, 65.5 ± 10.1 years) who were referred to undergo a first RFCA procedure were reviewed in this study...
October 15, 2018: Heart and Vessels
Hidekatsu Fukuta, Toshihiko Goto, Kazuaki Wakami, Takeshi Kamiya, Nobuyuki Ohte
Left ventricular (LV) diastolic dysfunction is associated with the pathophysiology of heart failure with preserved ejection fraction (HFpEF) and contributes importantly to exercise intolerance that results in a reduced quality of life (QOL) in HFpEF patients. Experimental studies have shown that aldosterone plays a role in the genesis of myocardial hypertrophy and fibrosis, thereby enhancing LV diastolic dysfunction, and that aldosterone antagonists (mineralocorticoid receptor antagonists [MRAs]) prevents myocardial hypertrophy and fibrosis...
October 12, 2018: Heart and Vessels
Kanako Ito-Hagiwara, Yu-Ki Iwasaki, Meiso Hayashi, Yujin Maru, Yuhi Fujimoto, Eiichiro Oka, Kenta Takahashi, Hiroshi Hayashi, Teppei Yamamoto, Kenji Yodogawa, Yasushi Miyauchi, Wataru Shimizu
A persistent left superior vena cava (PLSVC) is a congenital venous abnormality and is usually asymptomatic and does not cause hemodynamic disturbances. Therefore, it is difficult to identify it by routine examinations in clinical practice. This study aimed to elucidate the electrocardiographic characteristics for the prediction of a PLSVC. Twelve patients (9 males, 56.2 ± 18.3 years) who were diagnosed with a PLSVC were enrolled. The electrocardiographic parameters, including the P-wave duration, axis, and morphology of the P waves, were automatically measured and compared to 150 controls (77 males, 57...
October 12, 2018: Heart and Vessels
Martin Kozel, Viktor Kočka, Libor Lisa, Tomáš Buděšínský, Petr Toušek
A higher rate of bioresorbable vascular scaffold (BVS) thrombosis has been observed after device implantation compared to implantation of permanent metallic stents in recently published studies. The mechanism of BVS thrombosis is currently under debate. To assess whether the immune-inflammatory response after BVS implantation is a potential trigger of BVS thrombosis. The PRAGUE-19 study was an academic study that enrolled consecutive patients with ST-segment elevation myocardial infarction (STEMI) with the intention to implant a BVS...
October 12, 2018: Heart and Vessels
Alexander Pott, Kerstin Petscher, Michael Baumhardt, Tilman Stephan, Manuel Rattka, Rima Paliskyte, Carlo Bothner, Mirjam Keßler, Wolfgang Rottbauer, Tillman Dahme
Observation of the time-to-pulmonary vein isolation (TTI) by a spiral mapping catheter has emerged as a valuable procedural parameter in cryoballoon pulmonary vein isolation (PVI). The 1st generation spiral mapping catheter (Achieve, SMC1) has been available as an 8-polar catheter with a distal loop diameter of 15 or 20 mm. The novel spiral mapping catheter (Achieve Advance, SMC2) was designed as a true guidewire and is available, in addition to the sizes of the SMC1, as a 10-polar mapping catheter with a distal loop diameter of 25 mm...
October 9, 2018: Heart and Vessels
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