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Critical Reviews in Therapeutic Drug Carrier Systems

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https://www.readbyqxmd.com/read/30317969/polymeric-lipid-hybrid-nanoparticles-properties-and-therapeutic-applications
#1
Cyril Jose, Kesrin Amra, Chintan Bhavsar, Munira Momin, Abdelwahab Omri
Some of the criteria for selection of a viable nanocarrier formulation currently being explored are the development of a site-specific and bioavailable formulation. Although the literature reports a variety of techniques for fabrication of nanocarrier systems, their stability and scale-up issues are a concern for their prominence in the pharmaceutical industry. The other widely recognized drawbacks of nanoparticulates, i.e., polymeric nanoparticles and lipid vesicular nanoparticles (liposomes), are low circulatory half-lives due to reticuloendothelial system (RES) uptake and leaky architecture leading to burst kinetics...
2018: Critical Reviews in Therapeutic Drug Carrier Systems
https://www.readbyqxmd.com/read/30317968/polymer-based-drug-delivery-systems-for-cancer
#2
Ru Wen, Afoma C Umeano, Pingping Chen, Ammad Ahmad Farooqi
The standard treatment for metastatic cancer is generally a combination of chemotherapy, surgery, and radiotherapy. Since there are few specific chemotherapeutics approved by the US Food and Drug Administration, systemic chemotherapy is widely employed in the hopes of destroying rapidly dividing cancer cells before doing irreversible damage to the human body. Because of the nature of traditional chemotherapeutics, systemic treatment is associated with various side effects, such as nausea, dysphoria, vomiting, and pain, and long-term, irreversible damage to major organs, such as the kidney and heart...
2018: Critical Reviews in Therapeutic Drug Carrier Systems
https://www.readbyqxmd.com/read/30317967/smoking-cessation-potential-of-smartphone-assisted-behavioral-therapy-coupled-to-programmable-carbon-nanotube-membrane-nicotine-delivery-device
#3
Gaurav Kumar Gulati, Bruce J Hinds
Smoking tobacco continues to be a worldwide major cause of premature death. Although combined behavioral and pharmacotherapy interventions can increase the smoking cessation rate to nearly 25%, the combined approach is generally economically unattainable, and the low success rate leaves large populations at risk. Reviewed are treatments following primarily the principles of cognitive behavioral therapy (CBT) and nicotine replacement therapy (NRT), based on an addiction disease model with reduced dopamine receptors...
2018: Critical Reviews in Therapeutic Drug Carrier Systems
https://www.readbyqxmd.com/read/30317946/role-of-solid-gas-interface-of-nanobubbles-for-therapeutic-applications
#4
Pravin K Shende, Drashti Desai, R S Gaud
The development of nanoscale particles offers tremendous potential for the formulation of nanobubbles, an area of great interest in therapeutic ultrasound, detection, diagnosis, and drug delivery systems. This review compiles information for designing nanobubbles tailored to various applications such as color Doppler imaging, multidrug-resistant treatment, cosmeceuticals, gene therapy, cancer treatment, water treatment, and so forth. Nanobubbles also extend a path for convenient and eco-friendly systems for cleaning conducting surfaces...
2018: Critical Reviews in Therapeutic Drug Carrier Systems
https://www.readbyqxmd.com/read/30317945/updated-progress-of-nanocarrier-based-intranasal-drug-delivery-systems-for-treatment-of-brain-diseases
#5
Ying Fan, Min Chen, Jinqiang Zhang, Philippe Maincent, Xuefeng Xia, Wen Wu
Intranasal drug delivery is emerging as a reliable and promising pathway to deliver a wide range of therapeutic agents including small and large molecules, peptides and proteins, genes to the central nervous system for the treatment of brain diseases such as Alzheimer's disease, Parkinson's disease, depression, migraine, schizophrenia, and glioma. This presents noninvasive entry into the brain via direct nose-to-brain and/or indirect nose-to-blood-to-brain routes. Several nanocarrier-based strategies have been developed to transport therapeutic agents to the brain including nanoparticles, liposomes, and exosomes following intranasal delivery...
2018: Critical Reviews in Therapeutic Drug Carrier Systems
https://www.readbyqxmd.com/read/30317944/inorganic-nanoparticles-for-x-ray-computed-tomography-imaging
#6
Mohamed F Attia, Justine Wallyn, Nicolas Anton, Thierry F Vandamme
In the last two decades, nanoparticle contrast agents have emerged as an essential tool for preclinical imaging and diagnosis. Besides their main advantage, related to their size range inhibiting glomerular filtration, they exhibit excellent X-ray attenuation when fabricated with heavy metal and thus high contrast in tomodensitometry. Another strength of inorganic nanoparticles, making them very adaptable to preclinical imaging applications, is the modularity of their surface chemistry, which is compatible with decoration by ligands and biomolecules...
2018: Critical Reviews in Therapeutic Drug Carrier Systems
https://www.readbyqxmd.com/read/29972682/novel-stereoscopic-response-strategy-can-be-used-in-combination-therapy
#7
REVIEW
Zili Gu, Abdul Sami Shaikh, Guimei Lin
Future cancer therapy will depend on combination therapy with multiple drugs to achieve maximum effects and minimum toxicity. Due to the complexity and significance of the tumor microenvironment (TME), it is vital to elucidate this complicated environment when designing a co-delivery system. There are numerous potent target sites in the TME to facilitate simultaneous and selective delivery. Currently, nanocarriers are used frequently in co-delivery systems for multiple antitumor treatments. Nanocarriers can efficiently deliver drugs and achieve synergistic effects, but the potent barriers in the TME and their inherent limitations have restricted their use...
2018: Critical Reviews in Therapeutic Drug Carrier Systems
https://www.readbyqxmd.com/read/29972681/perspectives-of-lipid-based-drug-carrier-systems-for-transdermal-delivery
#8
REVIEW
Madhulika Pradhan, Shikha Srivastava, Deependra Singh, Shailendra Saraf, Swarnlata Saraf, Manju Rawat Singh
Transdermal delivery serves as non-invasive and effortless terminable means for systemic as well as topical drug delivery and finds itself as an option to conventional delivery route. Significant impervious nature of skin is the greatest hurdle for successful delivery of drug molecules to the deeper layers of skin for systemic absorption. Many approaches have been carried out for delivery of a medicament across skin barrier to enhance the efficacy. Among them lipid-based colloidal carriers have gained a unique position for transdermal delivery of drugs and bioactives owing to the presence of epidermal lipids as the chief component within the penetration barrier in high amount...
2018: Critical Reviews in Therapeutic Drug Carrier Systems
https://www.readbyqxmd.com/read/29972680/biomedical-applications-and-toxicological-aspects-of-functionalized-carbon-nanotubes
#9
REVIEW
Vijay Mishra, Prashant Kesharwani, Narendra Kumar Jain
Currently, nanomedicines exhibit implausible capability in overcoming the hurdles faced in gene therapy, cancer treatments, as well as other life-threatening diseases. Worldwide, the unique features of carbon nanotubes (CNTs) are still being explored by researchers to tap their potential. Different types of CNTs exhibit capabilities in the transportation of vaccines, bioactives, and nucleic acids deep into the cell to previously unreachable targets. This review sheds light on the different aspects of biomedical applications and toxicities associated with functionalized CNTs...
2018: Critical Reviews in Therapeutic Drug Carrier Systems
https://www.readbyqxmd.com/read/29953347/current-perspectives-on-novel-drug-carrier-systems-and-therapies-for-management-of-pancreatic-cancer-an-updated-inclusive-review
#10
REVIEW
Rohit Rajendra Bhosale, Hosahalli Veerabhadrappa Gangadharappa, Devegowda Vishakante Gowda, Riyaz Ali Mahafez Ali Osmani, Rudra Vaghela, Parthasarathi Keshavarao Kulkarni, Koganti Venkata Sairam, Bannimath Gurupadayya
Pancreatic cancer (PC) is one of the most fatal solid tumors, resulting in more than 250,000 deaths per year globally. It is the eighth leading cause of death from cancer in men and women throughout the world and is now third leading cause of cancer-related deaths in the United States. In addition, the worldwide occurrence of PC ranges from 1 to 10 cases per 100,000 people, indicating a higher incidence in developed countries. Most patients with locally advanced or metastatic disease are not candidates for curative resection due to enormously poor prognosis...
2018: Critical Reviews in Therapeutic Drug Carrier Systems
https://www.readbyqxmd.com/read/29717665/mannosylated-constructs-as-a-platform-for-cell-specific-delivery-of-bioactive-agents
#11
REVIEW
Sanjay Tiwari
Dictating the transport of drug carriers and augmenting the drug concentration at the desired anatomical site with high selectivity are worthwhile pursuits of current pharmaceutical research. Such approaches to drug targeting have been classified into passive and active strategies. As discussed in this article, active targeting promises greater selectivity because it exploits the incorporation of appropriate ligands, which are recognized by the target cells. Ligands, such as folate, peptides, transferrin, antibodies and their fragments, sugar, and sugar-mimetics, etc...
2018: Critical Reviews in Therapeutic Drug Carrier Systems
https://www.readbyqxmd.com/read/29717664/lipids-and-surfactants-the-inside-story-of-lipid-based-drug-delivery-systems
#12
REVIEW
Vikas Pandey, Seema Kohli
In the bioavailability enhancement of poorly aqueous soluble drugs, self-emulsifying/microemulsifying drug delivery systems (SEDDS/SMEDDS) are isotropic mixtures of oils, surfactants, solvents, and cosolvents/surfactants that have gained immense popularity because of their self-emulsification ability. This characteristic relies on some critical parameters such as surfactant concentration, oil-to-surfactant ratio, polarity of the emulsion, droplet size and charge, which are acquired from an amalgamation of appropriate excipients...
2018: Critical Reviews in Therapeutic Drug Carrier Systems
https://www.readbyqxmd.com/read/29611471/peroxisome-proliferated-activated-receptors-ppars-opportunities-and-challenges-for-ocular-therapy
#13
REVIEW
Prachi Khatol, Shivani Saraf, Ankit Jain
Peroxisome proliferator-activated receptors (PPARs) are nuclear transcription factors. They exist in three isoforms (PPAR-α, PPAR-β/δ, and PPAR-Υ) in humans, but mainly PPAR-Υ, and they are expressed in retinal epithelial pigment. PPARs are involved in mediating numerous pathological implications in eye such as diabetic retinopathy (DR), choroidal neovascularization (CNV), glaucoma, diabetic macular edema, and other retinal diseases. Peroxisome proliferator-activated receptors are key players in various biological pathways like lipid degeneration, immune regulation, and reactive oxygen species regulation, regulation of vascular endothelial growth factor, matrixmetalloproteinase-9, and docosahexaenoic acid pathway...
2018: Critical Reviews in Therapeutic Drug Carrier Systems
https://www.readbyqxmd.com/read/29611470/polymeric-immunonanoparticles-mediated-cancer-therapy-versatile-nanocarriers-for-cell-specific-cargo-delivery
#14
REVIEW
Namdev L Dhas, Ritu R Kudarha, Niyati S Acharya, Sanjeev R Acharya
The major drawback with conventional therapeutic approaches for cancer therapy is decreased efficacy and redundant therapy associated toxicity and side effects causing increased patient discomfort. With the aim of minimizing these limitations, a vast amount of attention has been given to targeted nanocarrier-based drug delivery systems that possess a several-fold advantage over conventional therapy. Increased research in targeted nanoparticulate systems has led to the development of immunonanoparticles with enhanced efficacy and targeting efficiency along with decreased drug-resistant cancer- and dose-related toxicity...
2018: Critical Reviews in Therapeutic Drug Carrier Systems
https://www.readbyqxmd.com/read/29256839/a-review-on-potential-of-proteins-as-an-excipient-for-developing-a-nano-carrier-delivery-system
#15
REVIEW
Amrita Chakraborty, Pubali Dhar
In neo-age research, nano-materials have emerged as potential tools for the revolution of diagnostic and therapeutic field because of their nano-scale effects, increased surface area-volume ratio, and other beneficial properties. For the last few decades, protein has been regarded as the most attractive and versatile natural bio-macromolecule among all of the available biopolymers. Protein is largely exploited as a nano-carrier system in the pharmaceutical industry due to its low cytotoxocity, biocompatibility, biodegradability, abundant renewable sources, significant attaching ability, clinically useful targeting, and site-specific efficient uptake...
2017: Critical Reviews in Therapeutic Drug Carrier Systems
https://www.readbyqxmd.com/read/29256838/emerging-trends-in-therapeutic-algorithm-of-chronic-wound-healers-recent-advances-in-drug-delivery-systems-concepts-to-clinical-application-and-future-prospects
#16
REVIEW
Mei Shao, Zahid Hussain, Hnin Ei Thu, Shahzeb Khan, Marcel de Matas, Victoria Silkstone, Hua-Li Qin, Syed Nasir Abbas Bukhari
Chronic wounds which include diabetic foot ulcer (DFU), pressure ulcer, and arterial or venous ulcers compel a significant burden to the patients, healthcare providers, and the healthcare system. Chronic wounds are characterized by an excessive persistent inflammatory phase, prolonged infection, and the failure of defense cells to respond to environmental stimuli. Unlike acute wounds, chronic nonhealing wounds pose a substantial challenge to conventional wound dressings, and the development of novel and advanced wound healing modalities is needed...
2017: Critical Reviews in Therapeutic Drug Carrier Systems
https://www.readbyqxmd.com/read/29256837/expanding-the-domain-of-drug-delivery-for-hiv-prevention-exploration-of-the-transdermal-route
#17
REVIEW
Ashana Puri, Arunprasad Sivaraman, Wei Zhang, Meredith R Clark, Ajay K Banga
Constant efforts for HIV prevention using antiretroviral drugs, pre- and postexposure prophylactic agents, and microbicides are being made by researchers. Drug-delivery systems such as oral tablets and coitally dependent vaginal gels are short acting, require daily application, and are associated with user adherence issues, whereas the coitally independent systems such as injectables and biodegradable implants are long acting, lasting several months, during which time the termination of prophylaxis is impractical in case of adverse effects...
2017: Critical Reviews in Therapeutic Drug Carrier Systems
https://www.readbyqxmd.com/read/29256836/clinical-success-versus-attrition-of-investigational-pharmaceuticals-a-vignette
#18
Ritu Gupta
The clinical success of investigational pharmaceuticals remains doubtful due to an unacceptable level of attrition during clinical drug development and declining clinical approval rates. Countless molecules are being withdrawn during drug discovery and clinical trial phases due to poor pharmacokinetics (ADME), lack of safety and efficacy, commercial interests, market competition, and patent protection expiry. Consequently, the novel drug pipelines are running dry. Because huge capital is involved in different clinical trial phases, the task of bringing a new drug or drug formulation to the market is a very costly venture...
2017: Critical Reviews in Therapeutic Drug Carrier Systems
https://www.readbyqxmd.com/read/29256835/implication-of-formulation-strategies-on-the-bioavailability-of-selected-plant-derived-hepatoprotectants
#19
REVIEW
Ranjeet Prasad Dash, Manika Kala, Manish Nivsarkar, R Jayachandra Babu
Plant-derived active ingredients with hepatoprotective activity have been used extensively in the treatment of various liver diseases. These compounds are used either in their natural form or the chemical constituents present therein serve as templates for the development of synthetic-based therapeutic entities. Current research interests are focused on formulation development and pharmacokinetic studies of herbal medicines. This article provides a comprehensive review on formulation influences on the preclinical/clinical pharmacokinetics of selected hepatoprotectants such as silymarin, curcumin, glycyrrhizin, andrographolide, phyllanthin, hypophyllanthin, and picroside I and II...
2017: Critical Reviews in Therapeutic Drug Carrier Systems
https://www.readbyqxmd.com/read/29199589/nanostructured-lipid-carriers-a-new-paradigm-in-topical-delivery-for-dermal-and-transdermal-applications
#20
REVIEW
Gajanand Sharma, Kanika Thakur, Kaisar Raza, Bhupinder Singh, Om Parkash Katare
Topical drug delivery offers many advantages over oral delivery, such as avoidance of first-pass metabolism, targeting of the active ingredients for a local effect, and patient compliance. However, the achievement of dermal and transdermal delivery needs to conciliate difficulties in permeation across skin barrier at different levels (skin surface, epidermis, dermis, and hypodermis). Nanostructured lipid carriers (NLCs) are recently invented second-generation lipidic carriers. The present article intends to provide an insight of composition, production, and application of these carriers in topical delivery for local and systemic effects...
2017: Critical Reviews in Therapeutic Drug Carrier Systems
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