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Journals Critical Reviews in Therapeuti...

Critical Reviews in Therapeutic Drug Carrier Systems

https://read.qxmd.com/read/38305342/targeting-pathways-and-integrated-approaches-to-treat-rheumatoid-arthritis
#1
JOURNAL ARTICLE
Shradha Devi Dwivedi, Krishna Yadav, Anita Bhoi, Keshav Kant Sahu, Neelam Sangwan, Deependra Singh, Manju Rawat Singh
Rheumatoid arthritis (RA) is a chronic symmetrical systemic disorder that not only affects joints but also other organs such as heart, lungs, kidney, and liver. Approximately there is 0.5%-1% of the total population affected by RA. RA pathogenesis still remains unclear due to which its appropriate treatment is a challenge. Further, multitudes of factors have been reported to affect its progression i.e. genetic factor, environmental factor, immune factor, and oxidative factor. Therapeutic approaches available for the treatment of RA include NSAIDs, DMARDs, enzymatic, hormonal, and gene therapies...
2024: Critical Reviews in Therapeutic Drug Carrier Systems
https://read.qxmd.com/read/38305341/plant-based-approaches-for-rheumatoid-arthritis-regulation-mechanistic-insights-on-pathogenesis-molecular-pathways-and-delivery-systems
#2
JOURNAL ARTICLE
Anita Bhoi, Shradha Devi Dwivedi, Deependra Singh, S Keshavkant, Manju Rawat Singh
Rheumatoid arthritis (RA) is classified as a chronic inflammatory autoimmune disorder, associated with a varied range of immunological changes, synovial hyperplasia, cartilage destructions, as well as bone erosion. The infiltration of immune-modulatory cells and excessive release of proinflammatory chemokines, cytokines, and growth factors into the inflamed regions are key molecules involved in the progression of RA. Even though many conventional drugs are suggested by a medical practitioner such as DMARDs, NSAIDs, glucocorticoids, etc...
2024: Critical Reviews in Therapeutic Drug Carrier Systems
https://read.qxmd.com/read/38305340/a-path-of-novelty-from-nanoparticles-to-nanobots-theragnostic-approach-for-targeting-cancer-therapy
#3
JOURNAL ARTICLE
Gursharanpreet Kaur, Bhawna Khanna, Mohammed Yusuf, Akanksha Sharma, Akhil Khajuria, Hema K Alajangi, Pradeep K Jaiswal, Mandip Sachdeva, Ravi Pratap Barnwal, Gurpal Singh
Pharmaceutical development of cancer therapeutics is a dynamic area of research. Even after decades of intensive work, cancer continues to be a dreadful disease with an ever-increasing global incidence. The progress of nanotechnology in cancer research has overcome inherent limitations in conventional cancer chemotherapy and fulfilled the need for target-specific drug carriers. Nanotechnology uses the altered patho-physiological microenvironment of malignant cells and offers various advantages like improved solubility, reduced toxicity, prolonged drug circulation with controlled release, circumventing multidrug resistance, and enhanced biodistribution...
2024: Critical Reviews in Therapeutic Drug Carrier Systems
https://read.qxmd.com/read/38037821/three-dimensional-printing-as-a-progressive-innovative-tool-for-customized-and-precise-drug-delivery
#4
JOURNAL ARTICLE
Kirti Aggarwal, Kalpana Nagpal
While using three-dimensional printing, materials are deposited layer by layer in accordance with the digital model created by computer-aided design software. Numerous research teams have shown interest in this technology throughout the last few decades to produce various dosage forms in the pharmaceutical industry. The number of publications has increased since the first printed medicine was approved in 2015 by Food and Drug Administration. Considering this, the idea of creating complex, custom-made structures that are loaded with pharmaceuticals for tissue engineering and dose optimization is particularly intriguing...
2024: Critical Reviews in Therapeutic Drug Carrier Systems
https://read.qxmd.com/read/38037820/stability-challenges-of-amorphous-solid-dispersions-of-drugs-a-critical-review-on-mechanistic-aspects
#5
JOURNAL ARTICLE
Muralidhar Pisay, Singh Padya, Srinivas Mutalik, Kunnatur B Koteshwara
The most common drawback of the existing and novel drug molecules is their low bioavailability because of their low solubility. One of the most important approaches to enhance the bioavailability in the enteral route for poorly hydrophilic molecules is amorphous solid dispersion (ASD). The solubility of compounds in amorphous form is comparatively high because of the availability of free energy produced during formulation. This free energy results in the change of crystalline nature of the prepared ASD to the stable crystalline form leading to the reduced solubility of the product...
2024: Critical Reviews in Therapeutic Drug Carrier Systems
https://read.qxmd.com/read/38037819/pharmaceutical-in-situ-gel-for-glaucoma-recent-trends-and-development-with-an-update-on-research-and-patents
#6
REVIEW
Rohitas Deshmukh, Rajesh Singh, Sakshi Mishra
Glaucoma is a progressive visual polyneuropathy characterized by retinal ganglion cell atrophy and optic nerve head changes. It's generally triggered due to increased intraocular pressure compared with the healthy eye. Glaucoma is treated with various medications in traditional eye drops, such as prostaglandins, carbonic anhydrase inhibitors, beta-blockers, and others. Such treatments are difficult to use and produce lachrymal leakage and inadequate corneal permeability, resulting in lower availability. Ophthalmic in situ gels, introduced in past decades with tremendous effort, are among the finest various choices to solve the drawbacks of eye drops...
2024: Critical Reviews in Therapeutic Drug Carrier Systems
https://read.qxmd.com/read/37938191/targeting-amyloids-with-coated-nanoparticles-a-review-on-potential-combinations-of-nanoparticles-and-bio-compatible-coatings
#7
REVIEW
Oshin D Warerkar, Niyati H Mudliar, Munira M Momin, Prabhat K Singh
Amyloidosis is the major cause of many neurodegenerative diseases, such as, Alzheimer's and Parkinson's where the misfolding and deposition of a previously functional protein make it inept for carrying out its function. The genesis of amyloid fibril formation and the strategies to inhibit it have been studied extensively, although some parts of this puzzle still remain unfathomable to date. Many classes of molecules have been explored as potential drugs in vitro, but their inability to work in vivo by crossing the blood-brain-barrier has made them an inadequate treatment option...
2024: Critical Reviews in Therapeutic Drug Carrier Systems
https://read.qxmd.com/read/37938190/copper-nanoclusters-as-novel-podium-for-cancer-detection-imaging-and-therapy-applications
#8
REVIEW
Ranjita Misra, A Sivaranjani, Suraiya Saleem, Bignya Rani Dash
Nanoclusters (NCs) are meticulously small, kinetically stable, crystalline materials which hold immense potential as multifaceted catalysts for a broad range of biomedical applications. Metal NCs are atomically precise and exist within the range of Fermi wavelength of electrons. They are highly advantageous as functional materials as their physicochemical properties can be customized to meet specific requirements. Copper NCs (CuNCs) are emerging as an efficient substitute to the other existing metal NCs. The synthesis of CuNCs is highly methodical, fast, cost effective and does not involve any complicated manipulation...
2024: Critical Reviews in Therapeutic Drug Carrier Systems
https://read.qxmd.com/read/37938189/current-insights-into-targeting-strategies-for-the-effective-therapy-of-diseases-of-the-posterior-eye-segment
#9
JOURNAL ARTICLE
Prachi Pimple, Apurva Sawant, Sujit Nair, Sujata P Sawarkar
The eye is one a unique sophisticated human sense organ with a complex anatomical structure. It is encased by variety of protective barriers as responsible for vision. There has been a paradigm shift in the prevalence of several major vision threatening ocular conditions with enhanced reliance on computer-based technologies in our workaday life and work-from-home modalities although aging, pollution, injury, harmful chemicals, lifestyle changes will always remain the root cause. Treating posterior eye diseases is a challenge faced by clinicians worldwide...
2024: Critical Reviews in Therapeutic Drug Carrier Systems
https://read.qxmd.com/read/37824419/advanced-technologies-of-drug-delivery-to-the-posterior-eye-segment-targeting-angiogenesis-and-ocular-cancer
#10
REVIEW
Mudassir Ansari, Yogesh A Kulkarni, Kavita Singh
Retinoblastoma (RB), a childhood retinal cancer is caused due to RB1 gene mutation which affects the child below 5 years of age. Angiogenesis has been proven its role in RB metastasis due to the presence of vascular endothelial growth factor (VEGF) in RB cells. Therefore, exploring angiogenic pathway by inhibiting VEGF in treating RB would pave the way for future treatment. In preclinical studies, anti-VEGF molecule have shown their efficacy in treating RB. However, treatment requires recurrent intra-vitreal injections causing various side effects along with patient nonadherence...
2024: Critical Reviews in Therapeutic Drug Carrier Systems
https://read.qxmd.com/read/37824418/novel-strategies-using-sagacious-targeting-for-site-specific-drug-delivery-in-breast-cancer-treatment-clinical-potential-and-applications
#11
REVIEW
Pedram Ebrahimnejad, Zahra Mohammadi, Amirhossein Babaei, Melika Ahmadi, Shervin Amirkhanloo, Kofi Asare-Addo, Ali Nokhodchid
For more than a decade, researchers have been working to achieve new strategies and smart targeting drug delivery techniques and technologies to treat breast cancer (BC). Nanotechnology presents a hopeful strategy for targeted drug delivery into the building of new therapeutics using the properties of nanomaterials. Nanoparticles are of high regard in the field of diagnosis and the treatment of cancer. The use of these nanoparticles as an encouraging approach in the treatment of various cancers has drawn the interest of researchers in recent years...
2024: Critical Reviews in Therapeutic Drug Carrier Systems
https://read.qxmd.com/read/37824417/applications-of-cannabinoids-in-neuropathic-pain-an-updated-review
#12
REVIEW
Peggy Arthur, Anil Kumar Kalvala, Sunil Kumar Surapaneni, Mandip Sachdeva Singh
Neuropathic pain is experienced due to injury to the nerves, underlying disease conditions or toxicity induced by chemotherapeutics. Multiple factors can contribute to neuropathic pain such as central nervous system (CNS)-related autoimmune and metabolic disorders, nerve injury, multiple sclerosis and diabetes. Hence, development of pharmacological interventions to reduce the drawbacks of existing chemotherapeutics and counter neuropathic pain is an urgent unmet clinical need. Cannabinoid treatment has been reported to be beneficial for several disease conditions including neuropathic pain...
2024: Critical Reviews in Therapeutic Drug Carrier Systems
https://read.qxmd.com/read/37585311/a-narrative-review-on-non-invasive-drug-delivery-of-teriparatide-a-ray-of-hope
#13
JOURNAL ARTICLE
Neeraj Mittal, Gajanand Sharma, Om Parkash Katare, Sanjay Kumar Bhadada
In the field of pharmaceutical biotechnology and formulation development, various protein and peptide-based drugs have been used for therapeutic and clinical implications. These are mainly given via parenteral routes like intravenous, subcutaneous or intramuscular delivery. Teriparatide, also known as PTH 1-34, is a U.S. Food & Drug Administartion-approved anabolic drug to treat osteoporosis is currently available in market only as subcutaneous injection. The quest for elimination of needle in case of given peptidal delivery to replace it with alternative routes like nasal, buccal, transdermal and pulmonary pathways has driven meticulous drug research...
2023: Critical Reviews in Therapeutic Drug Carrier Systems
https://read.qxmd.com/read/37585310/impact-of-nanotechnology-on-differentiation-and-augmentation-of-stem-cells-for-liver-therapy
#14
JOURNAL ARTICLE
Ifrah Anwar, Usman Ali Ashfaq
The liver is one of the crucial organs of the body that performs hundreds of chemical reactions needed by the body to survive. It is also the largest gland of the body. The liver has multiple functions, including the synthesis of chemicals, metabolism of nutrients, and removal of toxins. It also acts as a storage unit. The liver has a unique ability to regenerate itself, but it can lead to permanent damage if the injury is beyond recovery. The only possible treatment of severe liver damage is liver transplant which is a costly procedure and has several other drawbacks...
2023: Critical Reviews in Therapeutic Drug Carrier Systems
https://read.qxmd.com/read/37585309/advances-in-current-drugs-and-formulations-for-the-management-of-atopic-dermatitis
#15
REVIEW
Keerthi Atluri, Srikanth Manne, Vijendra Nalamothu, Alon Mantel, Purnendu K Sharma, R Jayachandra Babu
Atopic dermatitis (AD) is a chronic, relapsing inflammatory skin disease with a complex pathophysiology. Treatment of AD remains challenging owing to the presence of a wide spectrum of clinical phenotypes and limited response to existing therapies. However, recent genetic, immunological, and pathophysiological insights into the disease mechanism resulted in the invention of novel therapeutic drug candidates. This review provides a comprehensive overview of current therapies and assesses various novel drug delivery strategies currently under clinical investigation...
2023: Critical Reviews in Therapeutic Drug Carrier Systems
https://read.qxmd.com/read/37522550/recent-advances-in-teriparatide-delivery-by-virtue-of-novel-drug-delivery-approaches-for-the-management-of-osteoporosis
#16
JOURNAL ARTICLE
Sagar Salave, Dhwani Rana, Kedar Prayag, Srushti Shah, Garima Rawat, Nitish Sharma, Anil B Jindal, Rikin Patel, Derajram Benival
Osteoporosis is a bone incapacitating malady which globally accounts for over hundred million fractures annually. Therapeutic interventions for management of osteoporosis are divided as antiresorptive agents and osteoanabolic agents. Teriparatide is the only osteoana-bolic peptide which is available world-wide for the treatment of osteoporosis. It is administered as a daily subcutaneous injection for the treatment of osteoporosis which results in both poor patient compliance and increase in the cost of the therapy...
2023: Critical Reviews in Therapeutic Drug Carrier Systems
https://read.qxmd.com/read/37522549/an-overview-on-macrophage-targeting-a-promising-approach
#17
JOURNAL ARTICLE
Venkata Deepthi Vemuri, Rekharani Kushwaha, Gollu Gowri, Nalini Mathala, Swathi Nalla, Sasikala Allam, Gurijala Lekhya
Macrophages are immuno cells with high flexibility among hematopoietic system. Macrophages are tangled with many diseases like chronic inflammatory, atherosclerosis, autoimmune, and cancer. Macrophages play a major role in developing the inflammation and meanwhile resolving the damage occurred during these disease conditions. Therefore, the use of macrophages in targeted drug delivery appeared to be a promising approach in modifying the microenvironment of inflammatory diseases. The macrophages with cellular backpacks loaded with drugs were appeared to be the effective drug transporter to the brain inflammation...
2023: Critical Reviews in Therapeutic Drug Carrier Systems
https://read.qxmd.com/read/37522548/exploring-the-therapeutic-potential-of-cyclosporine-for-ophthalmic-indications-by-novel-carrier-systems
#18
REVIEW
Garima Rawat, Shital Kolhe, Dhwani Rana, Sagar Salave, Derajram Benival
Cyclosporine (CsA) stays the most intangible molecule holding a good history for treating several ophthalmic conditions and it even attributes to multiple off-label uses. Topical delivery of CsA is the most preferred route but owing to the molecule's physicochemical properties such as poor aqueous solubility and high molecular weight as well as its encounter with multiple barriers of eye causes hindrance for proper delivery of the molecule to the site of action. However, Restasis®, Cequa®, and Verkazia® are the marketed formulations that have been approved by U...
2023: Critical Reviews in Therapeutic Drug Carrier Systems
https://read.qxmd.com/read/37075069/exosomes-recent-advances-and-challenges-as-targeted-therapeutic-delivery-vesicles
#19
JOURNAL ARTICLE
Sourabh Jadhav, Ankaj Kumar, Arvind Gulbake
The exosome is a naturally derived nanostructured lipid vesicle that ranges from 40-100 nm in size and is utilized to transport drugs, and biological macromolecules, including therapeutic RNA and proteins. It is a membrane vesicle actively released by cells to transport cellular components with a purpose for biological events. The conventional isolation technique has several drawbacks, including low integrity, low purity, long processing time, and sample preparation. Therefore, microfluidic technologies are more widely accepted for the isolation of pure exosomes, but due to cost and expertise requirements, this technology is also facing challenges...
2023: Critical Reviews in Therapeutic Drug Carrier Systems
https://read.qxmd.com/read/37075068/nanotherapeutic-approach-to-delivery-of-chemo-and-gene-therapy-for-organ-confined-and-advanced-castration-resistant-prostate-cancer
#20
JOURNAL ARTICLE
Satish Sharma, Supriya D Mahajan, Kent Chevli, Stanley A Schwartz, Ravikumar Aalinkeel
Treatments for late-stage prostate cancer (CaP) have not been very successful. Frequently, advanced CaP progresses to castration-resistant prostate cancer (CRPC), with 50#37;-70% of patients developing bone metastases. CaP with bone metastasis-associated clinical complications and treatment resistance presents major clinical challenges. Recent advances in the formulation of clinically applicable nanoparticles (NPs) have attracted attention in the fields of medicine and pharmacology with applications to cancer and infectious and neurological diseases...
2023: Critical Reviews in Therapeutic Drug Carrier Systems
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