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Canadian Journal of Cardiology

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https://www.readbyqxmd.com/read/28153579/erratum
#1
(no author information available yet)
No abstract text is available yet for this article.
January 30, 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28132740/erratum
#2
(no author information available yet)
No abstract text is available yet for this article.
January 26, 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28318899/severe-aortic-stenosis-with-a-large-infra-aortic-annular-aneurysm-of-the-ventricular-septum-treated-with-corevalve
#3
Toru Naganuma, Hiroyoshi Kawamoto, Hiroto Yabushita, Tatsuya Nakao, Sunao Nakamura
No abstract text is available yet for this article.
January 25, 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28110802/primary-prevention-of-sudden-cardiac-death-with-device-therapy-in-urban-and-rural-populations
#4
Ratika Parkash, Howard Wightman, Graham Miles, John L Sapp, Martin Gardner, Chris Gray, Brenda Brownell, Karen Giddens, Miroslaw Rajda
BACKGROUND: Implantable cardioverter defibrillators (ICDs) have shown benefit in reducing mortality in patients with heart failure, after myocardial infarction, and those with reduced ejection fraction. We sought to explore the use of this therapy in specialized heart function clinics, in rural and urban locations. METHODS: This was a retrospective cohort study performed in 3 specialized heart function clinics in Nova Scotia, 2 of which were in rural locations. All patients with an initial left ventricular ejection fraction ≤ 35% were included from 2006 to 2011...
January 7, 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28279522/home-blood-pressure-telemonitoring-rationale-for-use-required-elements-and-barriers-to-implementation-in-canada
#5
REVIEW
Peter W Wood, Pierre Boulanger, Raj S Padwal
Contemporary hypertension guidelines strongly endorse the use of home blood pressure (BP) monitoring for hypertension diagnosis and management. However, barriers exist that prevent optimal use of home BP measurements. Patients might not follow the recommended home BP measurement protocol, might not take the required number of readings, and/or might report only selected readings to their providers. Providers might not calculate the mean (used for clinical decision-making) and/or incorporate home BP measurements into the medical record...
January 3, 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28232021/three-dimensional-and-conventional-carotid-ultrasound-for-assessment-of-carotid-plaque-in-a-stroke-patient-a-simple-way-to-validate-findings
#6
Hayrapet Kalashyan, Maher Saqqur, Harald Becher, Cian O'Kelly, Helen Romanchuk, Khurshid Khan, Thomas Jeerakathil, Andrew Wassef, Ashfaq Shuaib
Single-sweep automated 3-D ultrasound is a new imaging modality for the assessment of carotid plaque. Its most important application is the measurement of the plaque volume. To our knowledge, to date there is not a widely accepted "gold standard" to validate 3-D plaque volume measurement. We compared the findings of 2-dimensional and 3-D carotid ultrasound imaging with those of postsurgical plaque specimen using a simple method.
March 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28232020/barriers-to-the-implementation-of-lipoprotein-apheresis-in-canada
#7
Guido Filler, Misan Lee, Robert A Hegele
This article details the effectiveness of using lipoprotein apheresis (LA) rather than plasmapheresis in patients with homozygous familial hypercholesterolemia (HoFH), using results from the first HoFH pediatric patient treated with LA in Ontario. We further detail the barriers involved in adhering to international guidelines by implementing this as a first-line treatment for this condition in Ontario, and the potential savings that would be gained with treating the remaining HoFH patients in this province with LA...
March 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28232019/optimal-low-density-lipoprotein-cholesterol-for-cardiovascular-prevention-how-low-should-we-go
#8
Todd J Anderson
The treatment of dyslipidemia with lifestyle interventions and statin-based therapy has been an important defense against atherosclerotic cardiovascular disease and its complications. It has been well documented for more than 2 decades that 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase inhibitors (statins) reduce the risk of events. The evolution of drug development and randomized clinical trials in cardiovascular medicine has resulted in the conclusion that lower cholesterol concentrations result in greater benefit...
March 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28232018/the-emerging-epidemic-of-cardiovascular-risk-factors-and-atherosclerotic-disease-in-developing-countries
#9
REVIEW
Koon K Teo, Hisham Dokainish
Cardiovascular disease (CVD) and its risk factors, which are major health burdens in high-income countries, are a growing problem in developing or lower-income countries, where the vast majority of CVD now occurs. Two case-control studies, INTERHEART and INTERSTROKE, which included a majority of patients from developing countries, were seminal in identifying common risk factors explaining the vast majority of risk for acute myocardial infarction and stroke, respectively. The population-based Prospective Urban and Rural Epidemiological (PURE) study, which included > 150,000 participants, also with a majority from developing countries, found that although high-income countries were at highest cardiovascular (CV) risk, they had the lowest incidence of CVD and associated case-fatality rates, whereas patients in low-income countries had the lowest CV risk and yet the highest CVD and case-fatality rates...
March 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28232017/micrornas-in-the-pathobiology-and-therapy-of-atherosclerosis
#10
REVIEW
Benoit Laffont, Katey J Rayner
MicroRNAs are short noncoding RNAs, expressed in humans and involved in sequence-specific post-transcriptional regulation of gene expression. They have emerged as key players in a wide array of biological processes, and changes in their expression and/or function have been associated with plethora of human diseases. Atherosclerosis and its related clinical complications, such as myocardial infarction or stroke, represent the leading cause of death in the Western world. Accumulating experimental evidence has revealed a key role for microRNAs in regulating cellular and molecular processes related to atherosclerosis development, ranging from risk factors, to plaque initiation and progression, up to atherosclerotic plaque rupture...
March 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28232016/macrophage-apoptosis-and-necrotic-core-development-in-atherosclerosis-a-rapidly-advancing-field-with-clinical-relevance-to-imaging-and-therapy
#11
REVIEW
Leticia Gonzalez, Bernardo Louis Trigatti
Cardiovascular diseases represent 1 of the main causes of death worldwide, and atherosclerosis is 1 of the major contributors leading to ischemic heart disease. Macrophages actively participate in all stages of atherosclerosis development, from plaque initiation to the transition to vulnerable plaques. Macrophage apoptosis, in particular, has been recognized as a critical step in the formation of the necrotic core, a key characteristic of unstable lesions. In this review, we discuss the role of macrophage apoptosis and clearance of apoptotic cells by efferocytosis in the development of atherosclerosis, with particular emphasis on their contribution to the development of the necrotic core and the clinical implications of this process for plaque stabilization...
March 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28129964/recent-temporal-changes-in-atherosclerotic-cardiovascular-diseases-in-ontario-clinical-and-health-systems-impact
#12
Jack V Tu, Anam M Khan, Kelvin Ng, Anna Chu
BACKGROUND: It is unknown how the contemporary burden of atherosclerotic cardiovascular disease (ASCVD) compares with historical trends. METHODS: As part of the Cardiovascular Health in Ambulatory Care Research Team "big data" initiative, we used information from multiple population-based databases to study 20-year temporal trends in hospitalizations and deaths from ASCVD. We calculated hospitalization rates for 6 ASCVD events (acute myocardial infarction, unstable angina, stroke, transient ischemic attack, peripheral arterial disease, and congestive heart failure) and death rates resulting from ischemic heart disease, cerebrovascular disease and circulatory and noncirculatory causes in adults aged 20-105 years in Ontario, Canada from 1994-2014 (to 2012 for deaths)...
March 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28109622/genetics-for-the-identification-of-lipid-targets-beyond-pcsk9
#13
REVIEW
Linda R Wang, Robert A Hegele
From studies of rare families to genome-wide associations in populations, understanding of human genetics has accelerated the search for new drug targets for the prevention of atherosclerotic cardiovascular disease. DNA sequencing and genome-wide analyses of DNA markers have illuminated rare as well as common variants in genes that regulate lipids and ultimately atherosclerosis risk. A recent innovative approach called Mendelian randomization can endorse specific genes and variants as causative not just for lipid disturbances, but also for clinical cardiovascular end points...
March 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28081868/the-rise-and-fall-of-tuberculosis-and-atherosclerosis-first-there-is-a-mountain%C3%A2
#14
EDITORIAL
David D Waters
No abstract text is available yet for this article.
March 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28063740/high-density-lipoproteins-biology-epidemiology-and-clinical-management
#15
REVIEW
Hong Y Choi, Anouar Hafiane, Adel Schwertani, Jacques Genest
High-density lipoproteins (HDLs) have multiple pleiotropic effects against arteriosclerosis. Most are independent of the cholesterol mass within HDL particles. Yet, HDL cholesterol (HDL-C) remains a biomarker to assess cardiovascular risk. Whereas the epidemiological association between HDL-C and cardiovascular risk is strong, graded and coherent across populations, Mendelian randomization studies cast doubt on whether HDL-C is causally related to atherosclerotic cardiovascular disease. The apparent failure of HDL-C-raising therapies (fibrates, niacin, and cholesteryl ester transfer protein inhibitors) raises questions about the HDL-C hypothesis...
March 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28034582/an-evidence-based-guide-to-cholesterol-lowering-guidelines
#16
REVIEW
David D Waters, S Matthijs Boekholdt
Since 2014, guidelines for the management of lipid disorders to reduce cardiovascular (CV) events have been updated in the United States, the United Kingdom, Europe, and Canada. Some of these guidelines are almost entirely evidence-based whereas others are a mix of evidence and expert opinion. Guidelines differ on such simple questions as to whether blood samples should be fasting or nonfasting, and whether low-density lipoprotein cholesterol (LDL-C) or another lipid parameter should be the primary focus of treatment...
March 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/27993452/new-drugs-for-atherosclerosis
#17
REVIEW
Caroline S Bruikman, Robert M Stoekenbroek, G Kees Hovingh, John P Kastelein
Atherosclerosis, the underlying process that ultimately leads to clinical cardiovascular disease (CVD), is caused by the multifactorial interaction of various conditions, and dyslipidemia is widely acknowledged as 1 of the crucial risk factors in this process. Statin drugs have been shown to decrease low-density lipoprotein cholesterol and CVD morbidity as well as mortality and are therefore pivotal in CVD prevention. Despite the use of statin drugs, CVD remains a leading cause of mortality worldwide, which suggests that additional lipid-lowering therapies are warranted...
March 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/27993451/familial-hypercholesterolemia-awareness-appraisal-and-action
#18
EDITORIAL
Jacques Genest
No abstract text is available yet for this article.
March 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/27956041/effective-management-of-cardiovascular-risk-factors-are-we-doing-enough
#19
EDITORIAL
Koon K Teo, Hisham Dokainish
No abstract text is available yet for this article.
March 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/27931859/contemporary-trends-in-the-management-and-outcomes-of-patients-with-familial-hypercholesterolemia-in-canada-a%C3%A2-prospective-observational-study
#20
Liam R Brunham, Lubomira Cermakova, Terry Lee, Ida Priecelova, Karine Alloul, Marilyn de Chantal, Gordon A Francis, Jiri Frohlich
BACKGROUND: Heterozygous familial hypercholesterolemia (HeFH) is one of the most common genetic diseases in the world and an important cause of premature cardiovascular (CV) disease. The purpose of this study was to characterize the clinical features, current treatment patterns, and CV outcomes of patients with HeFH in British Columbia, Canada. METHODS: We conducted a longitudinal observational study of patients with HeFH attending a specialized lipid clinic. We collected data on lipid levels, medication use, and CV events at baseline and last follow-up...
March 2017: Canadian Journal of Cardiology
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