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Canadian Journal of Cardiology

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https://www.readbyqxmd.com/read/28395866/cardiac-amyloidosis-phenotype-associated-with-a-glu89lys-transthyretin-mutation
#1
Pierre R Bourque, Arleigh R McCurdy, Lisa M Mielniczuk, Carole Dennie, John P Veinot, Jodi Warman Chardon
We report a 45-year-old man with rapidly progressive cardiac amyloidosis, who required heart transplantation within 2 years of symptomatic onset. Hematologic testing and initial tissue biopsy results confirmed amyloid infiltration but were inconclusive for the amyloidogenic protein source. Mass spectroscopy and transthyretin (TTR) sequencing were required to reach a diagnosis of TTR amyloidosis resulting from a Glu89Lys mutation. Although a predominantly neuropathic phenotype has previously been described with this mutation, the present kinship documents a primarily cardiac presentation...
February 3, 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28434533/performance-of-fixed-heart-rate-increment-targets-of-20-vs-30-beats-per-minute-for-exercise-rehabilitation-prescription-in-outpatients-with-heart-failure
#2
Jennifer L Reed, Angelica Z Blais, Marja-Leena Keast, Andrew L Pipe, Robert D Reid
BACKGROUND: Patients with heart failure (HF) should exercise at 40%-60% heart rate reserve (HRR) during the first 3 weeks of an outpatient cardiac rehabilitation (CR) program and at 50%-80% HRR thereafter. Arbitrary methods to prescribe exercise intensity such as resting HR (RHR) plus 20 or 30 beats per minute (bpm) (RHR + 20 or RHR + 30) are recommended for inpatients after a myocardial infarction or those recovering from heart surgery. This approach has been repurposed by outpatient CR programs to prescribe exercise intensity for patients with HF, yet its efficacy has not been evaluated...
February 2, 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28395867/key-questions-relating-to-left-ventricular-noncompaction-cardiomyopathy-is-the-emperor-still-wearing-any-clothes
#3
REVIEW
Robert H Anderson, Bjarke Jensen, Timothy J Mohun, Steffen E Petersen, Nay Aung, Filip Zemrak, R Nils Planken, David H MacIver
The evidence is increasing that left ventricular noncompaction cardiomyopathy as it is currently defined does not represent a failure of compaction of pre-existing trabecular myocardium found during embryonic development to form the compact component of the ventricular walls. Neither is there evidence of which we are aware to favour the notion that the entity is a return to a phenotype seen in cold-blooded animals. It is also known that when seen in adults, the presence of excessive ventricular trabeculations does not portend a poor prognosis when the ejection fraction is normal, with the risks of complications such as arrhythmia and stroke being rare in this setting...
February 1, 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28377065/black-aortic-valve-a-surprise-finding-of-what-clinical-relevance
#4
Hussein A Al-Amodi, Edward J Tweedie, Ivan Iglesias, Michael W A Chu
No abstract text is available yet for this article.
February 1, 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28377066/same-day-discharge-after-transradial-percutaneous-coronary-intervention-and-carotid-stenting-in-a-single-session
#5
Olivier F Bertrand, Zoltan Ruzsa, Alberto Barria Perez, Robert De Larochellière
Same-day discharge after combined percutaneous carotid and coronary stenting in a single session has not been previously reported. Using a transradial approach, we completed both procedures successfully and the 63-year-old patient was discharged home after a few hours. This case illustrates that radial access allows treatment of complex coronary and peripheral lesions in a same setting and could provide clinical and cost benefits if safety is confirmed.
January 31, 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28153579/erratum
#6
(no author information available yet)
No abstract text is available yet for this article.
January 30, 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28392272/a-new-preprocedure-risk-score-for-predicting-contrast-induced-acute-kidney-injury
#7
Chongyang Duan, Yingshu Cao, Yong Liu, Lizhi Zhou, Kaike Ping, Ming T Tan, Ning Tan, Jiyan Chen, Pingyan Chen
BACKGROUND: Most of the risk models for predicting contrast-induced acute kidney injury (CI-AKI) are available for only postcontrast exposure prediction; however, prediction before the procedure is more valuable in practice. This study aimed to develop a risk scoring system based on preprocedural characteristics for early prediction of CI-AKI in patients after coronary angiography or percutaneous coronary intervention (PCI). METHODS: We prospectively recruited 1777 consecutive patients who were randomized in an approximate 3:2 ratio to create a development data set (n = 1076) and a validation data set (n = 701)...
January 28, 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28343609/very-late-onset-dabigatran-induced-esophageal-injury
#8
Ko Fujikawa, Nobuhiro Takasugi, Tadao Goto, Shinya Minatoguchi
An 87-year-old man with persistent atrial fibrillation experienced heartburn and dysphagia at 2 years 9 months after initiation of dabigatran. An esophagogastroduodenoscopy demonstrated multiple longitudinal white plaques with ulcers in the narrowed midesophagus compressed between the left atrium and the tortuous aorta. We speculate that the esophageal stenosis contributed to stasis of dabigatran within the esophagus, resulting in prolonged mucosal contact with the caustic contents of the drug. Progressive enlargement of the left atrium may have led to the late onset of the potentially serious complication...
April 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28343608/management-of-bilateral-axillary-aneurysms-threatened-limb-and-diffuse-vasculopathy-in-a-patient-with-acta2-mutation
#9
Michelle Keir, Wissam Al-Jundi, Maral Ouzounian, Andrew M Crean, Suzanne Hemeon, Sheri Horsburgh, Thomas L Forbes, Erwin N Oechslin
We describe the case of a 36-year-old man with bilateral axillary artery aneurysms and a threatened upper limb. We postulate that his aneurysms and diffuse vasculopathy resulted from a missense mutation identified in his ACTA2 gene known to be highly pathogenic. The risk factors and sequelae of axillary aneurysms are reviewed, with a focus on their surgical management and the effect of ACTA2 mutations on the cardiorespiratory system.
April 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28343607/bioresorbable-vascular-scaffold-during-st-elevation-myocardial-infarction-a-systematic-review
#10
REVIEW
Fabien Picard, Quentin de Hemptinne, Robert Avram, Hung Q Ly, Philippe L L'Allier, Jean-François Tanguay
BACKGROUND: The bioresorbable vascular scaffold (BVS) represents a novel technology designed to overcome the long-term limitations of metallic coronary stent implantation in percutaneous coronary intervention. In this context, primary percutaneous coronary intervention in ST-elevation myocardial infarction (STEMI) could be a preferred scenario for BVS implantation. Nevertheless, data on efficacy and safety are lacking in this specific subset of patients. METHODS: We conducted a systematic review to examine the safety and efficacy of BVS use in STEMI patients...
April 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28343606/respiratory-muscles-and-chemoreflex-sensitivity-in-heart-failure-a-breath-of-fresh-air
#11
EDITORIAL
Richard Severin, Shane A Phillips
No abstract text is available yet for this article.
April 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28343605/treatment-for-patients-with-chronic-thromboembolic-pulmonary-hypertension-where-does-balloon-pulmonary-angioplasty-sit-in-the-treatment-algorithm
#12
EDITORIAL
Christine L D'Arsigny
No abstract text is available yet for this article.
April 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28343604/tracking-syncope-in-canada-using-administrative-data-what-lessons-can-we-learn-where-do-we-need-to-be
#13
EDITORIAL
Marc W Deyell, Jason G Andrade
No abstract text is available yet for this article.
April 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28343603/cardioversion-for-atrial-fibrillation-improves-quality-of-life-it-s-obvious-or-isn-t-it
#14
EDITORIAL
Paul Dorian, Andrew C T Ha
No abstract text is available yet for this article.
April 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28259368/practices-and-attitudes-of-canadian-cardiologists-caring-for-patients-with-trisomy-18
#15
Aisling A Young, Christy Simpson, Andrew E Warren
Trisomy 18 (T18) is a genetic disorder with cardiac lesions in up to 90% of patients. Cardiac surgery is not frequently offered because of the overall poor prognosis, although this has recently been challenged. Our study aimed to explore the practices and attitudes of Canadian pediatric cardiologists managing T18 patients. We administered a survey to pediatric cardiologists attending the Canadian Cardiovascular Congress, Canadian Pediatric Cardiology Association Business Meeting. There were 30 respondents. Most (67%) supported comfort care for affected patients with a heart lesion...
April 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28222921/relationships-between-left-ventricular-structure-and-function-according-to-cardiac-mri-and-cardiac-biomarkers-in-end-stage-renal-disease
#16
Bryan A Ross, Ron Wald, Marc B Goldstein, Darren A Yuen, Jonathon Leipsic, Mercedeh Kiaii, Andrea Rathe, Djeven P Deva, Anish Kirpalani, Olugbenga O Bello, John J Graham, Howard Leong-Poi, Kim A Connelly, Andrew T Yan
BACKGROUND: We sought to assess the relationships between left ventricular (LV) remodelling and the mechanical and uremic stressors in hemodialysis patients. METHODS: In this prospective 2-centre cohort study, 67 prevalent hemodialysis patients were followed for 1 year. Data on routine bloodwork and predialysis blood pressure (BP) measurements were collected over a 12-week period. LV end-diastolic volume (LVEDV) and LV mass (LVM) were measured using cardiac magnetic resonance imaging and indexed...
April 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28169091/predictors-of-excess-patient-radiation-exposure-during-chronic-total-occlusion-coronary-intervention-insights-from-a-contemporary-multicentre-registry
#17
Georgios E Christakopoulos, Georgios Christopoulos, Dimitri Karmpaliotis, Khaldoon Alaswad, Robert W Yeh, Farouc A Jaffer, Michael R Wyman, William L Lombardi, Muhammad Nauman J Tarar, J Aaron Grantham, David E Kandzari, Nicholas Lembo, Jeffrey W Moses, Ajay J Kirtane, Manish Parikh, Philip Green, Matthew Finn, Santiago Garcia, Anthony H Doing, Raja Hatem, Craig A Thompson, Subhash Banerjee, Emmanouil S Brilakis
BACKGROUND: High patient radiation dose during chronic total occlusion (CTO) percutaneous coronary intervention (PCI) might lead to procedural failure and radiation skin injury. METHODS: We examined the association between several clinical and angiographic variables on patient air kerma (AK) radiation dose among 748 consecutive CTO PCIs performed at 9 experienced US centres between May 2012 and May 2015. RESULTS: The mean age was 65 ± 10 years, 87% of patients were men, and 35% had previous coronary artery bypass graft surgery (CABG)...
April 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28129965/genetic-risk-scores-for-atrial-fibrillation-do-they-improve-risk-estimation
#18
EDITORIAL
Henry D Huang, Dawood Darbar
No abstract text is available yet for this article.
April 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28340996/diabetes-for-cardiologists-practical-issues-in-diagnosis-and-management
#19
REVIEW
G B John Mancini, Alice Y Cheng, Kim Connelly, David Fitchett, Ronald Goldenberg, Shaun G Goodman, Lawrence A Leiter, Eva Lonn, Breay Paty, Paul Poirier, James Stone, David Thompson, Jean-François Yale
Diabetes mellitus (DM), a chronic metabolic disease characterized by hyperglycemia, is a profound cardiovascular (CV) risk factor. It compounds the effects of all other risk factors, leads to premature micro- and macrovascular disease, facilitates development of heart failure, worsens the clinical course of all CV diseases, and shortens life expectancy. Established DM, unrecognized DM, and dysglycemia that may progress to DM are all commonly present at the time of presentation of overt CV disease. Thus, CV specialists and trainees frequently treat patients with dysglycemia...
March 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28232021/three-dimensional-and-conventional-carotid-ultrasound-for-assessment-of-carotid-plaque-in-a-stroke-patient-a-simple-way-to-validate-findings
#20
Hayrapet Kalashyan, Maher Saqqur, Harald Becher, Cian O'Kelly, Helen Romanchuk, Khurshid Khan, Thomas Jeerakathil, Andrew Wassef, Ashfaq Shuaib
Single-sweep automated 3-D ultrasound is a new imaging modality for the assessment of carotid plaque. Its most important application is the measurement of the plaque volume. To our knowledge, to date there is not a widely accepted "gold standard" to validate 3-D plaque volume measurement. We compared the findings of 2-dimensional and 3-D carotid ultrasound imaging with those of postsurgical plaque specimen using a simple method.
March 2017: Canadian Journal of Cardiology
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