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Canadian Journal of Cardiology

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https://www.readbyqxmd.com/read/28455163/sex-differences-in-outcomes-after-discharge-from-the-emergency-department-for-atrial-fibrillation-flutter
#1
Rhonda J Rosychuk, Brian R Holroyd, Xuechen Zhang, Brian H Rowe, Michelle M Graham
BACKGROUND: Atrial fibrillation and flutter (AFF) are the most common arrhythmias presenting to emergency departments (EDs). We examined sex differences in outcomes for patients with AFF discharged from the ED in Alberta, Canada. METHODS: ED presentations for AFF during 1999-2011 that ended in discharge were extracted from administrative databases for all Alberta residents (age ≥ 35 years). Multivariable models determined the effect of sex on the time to ED return for AFF, the first follow-up visit with a physician, the first follow-up visit with a specialist (cardiologist or internal medicine physician), and death...
April 17, 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28461000/potential-sunitinib-induced-coronary-artery-and-aortic-dissections
#2
Raja Hatem, Emmanuel Bebawi, Erick Schampaert
Small-molecule multitargeted tyrosine kinase inhibitor (TKI) therapy is used in different types of cancer. These drugs have been associated with cardiovascular toxicity, including aortic dissection. To our knowledge, this is the first time that a coronary dissection potentially associated with a TKI treatment has been described.
March 9, 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28461001/left-atrial-dissection-after-percutaneous-transluminal-mitral-valvuloplasty
#3
Pietro Di Santo, Trevor Simard, Jean-Francois Marquis, Benjamin Hibbert
No abstract text is available yet for this article.
March 2, 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28457737/atrial-fibrillation-and-end-stage-renal-failure-in-patients-receiving-dialysis-balancing-the-risks-and-benefits-of-stroke-prevention
#4
EDITORIAL
Christos Voukalis, Gregory Y H Lip
No abstract text is available yet for this article.
February 28, 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28545626/very-late-continued-reverse-remodelling-after-cardiac-resynchronization-therapy-in-patients-with-extreme-left-ventricular-dilatation
#5
Samuel Larue-Grondin, François Philippon, Jean-François Sarrazin, Sacha-Michelle Dubois-Sénéchal, Michelle Dubois, Mario Sénéchal
Response to cardiac resynchronization therapy (CRT) varies greatly among patients. We present 2 patients with severe heart failure symptoms (New York Heart Association class IV) and extreme initial left ventricular (LV) dilatation (LV end-diastolic diameter of 92 mm and 80 mm, respectively) and severe functional mitral regurgitation who underwent CRT device implantation. Long-term follow-up showed late (≥ 4 years) normalization of LV ejection fraction (LVEF), LV dimensions, and functional status. In a subgroup of patients with nonischemic dilated cardiomyopathy and complete left bundle branch block, late continued LV reverse remodelling may lead to normalization of LV volumes and LVEF and significant improvement in functional class...
June 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28545625/a-home-based-walking-program-improves-respiratory-endurance-in-patients-with-acute-myocardial-infarction-a-randomized-controlled-trial
#6
Bruna C Matos-Garcia, Isadora S Rocco, Lara D Maiorano, Thatiana C A Peixoto, Rita Simone L Moreira, Antonio C C Carvalho, Aparecida Maria Catai, Ross Arena, Walter J Gomes, Solange Guizilini
BACKGROUND: The purpose of this study was to evaluate respiratory muscle strength and endurance in the inpatient period in patients who recently experienced myocardial infarction (MI) and investigate the effects of a home-based walking program on respiratory strength and endurance in low-risk patients after MI. METHODS: Patients were randomized into a usual-care group (UCG) entailing regular care (n = 23) and an intervention group (IG) entailing an outpatient home-based walking program (n = 31)...
June 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28545624/drug-development-for-heart-failure-with-preserved-ejection-fraction-what-pieces-are-missing-from-the-puzzle
#7
REVIEW
Michele Senni, Stephen J Greene, Javed Butler, Gregg C Fonarow, Mihai Gheorghiade
Despite the growing number of patients with heart failure with preserved ejection fraction (HFpEF) and event rates comparable with many cancers, there remain no pharmacologic agents definitively proven to improve patient outcomes. Although phase II trials have intermittently yielded encouraging results, none have translated into successful achievement of a phase III primary end point. Thus, because of the urgent need to discover proven therapies, it is prudent to reevaluate our current approach to HFpEF drug development...
June 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28545623/genetic-determinants-of-hereditary-bradyarrhythmias-a-contemporary-review-of-a-diverse-group-of-disorders
#8
REVIEW
Saman Rezazadeh, Henry J Duff
Bradyarrhythmia is a common clinical presentation. Although the majority of cases are acquired, genetic screening of families with bradyarrhythmia has led to the discovery of a growing number of causative hereditary mutations. These mutations can interfere with any of the steps required for the occurrence of each cardiac cycle, including generation of an action potential in the sinoatrial node, successful exit of the action potential from the node, propagation of the action potential throughout the atria until the depolarization waves reach the atrioventricular node, and finally transmission of the action potential to the ventricles through the His-Purkinje system...
June 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28545622/warfarin-and-the-risk-of-stroke-and-bleeding-in-patients-with-atrial-fibrillation-receiving-dialysis-a-systematic-review-and-meta-analysis
#9
REVIEW
Ziv Harel, Glenn M Chertow, Prakesh S Shah, Shai Harel, Paul Dorian, Andrew T Yan, Gustavo Saposnik, Manish M Sood, Amber O Molnar, Jeffrey Perl, Rachel M Wald, Sam Silver, Ron Wald
BACKGROUND: Patients with atrial fibrillation who receive dialysis are at a high risk of ischemic stroke. The role of warfarin in mitigating this risk in patients with atrial fibrillation who receive dialysis is uncertain. Our objective was to examine the safety and efficacy of warfarin in patients who have atrial fibrillation and receive dialysis. METHODS: We used MedLine, Embase, and the Cochrane Library to conduct a systematic review and meta-analysis of published and unpublished observational and interventional studies related to the use of warfarin in patients with atrial fibrillation who receive dialysis, and provided data on the risk of stroke and/or bleeding outcomes relative to placebo or no anticoagulation therapy...
June 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28545621/risk-prediction-models-for-contrast-induced-acute-kidney-injury-accompanying-cardiac-catheterization-systematic-review-and-meta-analysis
#10
REVIEW
David W Allen, Bryan Ma, Kelvin C Leung, Michelle M Graham, Neesh Pannu, Mouhieddin Traboulsi, David Goodhart, Merril L Knudtson, Matthew T James
BACKGROUND: Identification of patients at risk of contrast-induced acute kidney injury (CI-AKI) is valuable for targeted prevention strategies accompanying cardiac catheterization. METHODS: We searched MedLine and EMBASE for articles that developed or validated a clinical prediction model for CI-AKI or dialysis after angiography or percutaneous coronary intervention. Random effects meta-analysis was used to pool c-statistics of models. Heterogeneity was explored using stratified analyses and meta-regression...
June 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28545620/on-contrast-induced-acute-kidney-injury-risk-prediction-and-the-future-of-predictive-model-development
#11
EDITORIAL
Lorenzo Azzalini, Xavier Garcia-Moll
No abstract text is available yet for this article.
June 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28545619/peripheral-vascular-interventions-and-the-cardiologist-more-than-a-pain-in-the-neck-a-belly-ache-an-arm-and-a-leg%C3%A2
#12
EDITORIAL
Jean-François Dorval
No abstract text is available yet for this article.
June 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28545618/nosology-of-noncompaction-cardiomyopathy-the-emperor-still-wears-clothes
#13
EDITORIAL
Erwin Oechslin, Rolf Jenni
No abstract text is available yet for this article.
June 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28460999/dyspnea-attributed-to-ticagrelor-variable-tolerability-in-different-clinical-settings
#14
LETTER
Dimitrios Alexopoulos, John Lekakis
No abstract text is available yet for this article.
June 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28132740/erratum
#15
(no author information available yet)
No abstract text is available yet for this article.
June 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28449841/multimodal-images-of-a-large-spontaneous-aortic-root-pseudoaneurysm-with-right-atrium-and-tricuspid-annulus-compression
#16
Hao Yang, Kang Jun Fan, Hui Wang, Jia Hu
No abstract text is available yet for this article.
May 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28449840/collectively-operated-fellow-initiated-research-as-a-novel-teaching-model-to-bolster-interest-and-increase-proficiency-in-academic-research
#17
Guillaume Marquis-Gravel, Robert Avram, Maxime Tremblay-Gravel, Olivier Desplantie, Hung Q Ly, Anique Ducharme, E Marc Jolicoeur
Research is a core aspect of training in academic medicine, but fellows face many challenges thwarting their ability to perform clinically meaningful projects. The concept of a multicentre clinical trial collectively operated by fellows, and integrated longitudinally into training, has never been described. In this article, the authors expose the key principles of Collectively Operated Fellow-Initiated Research (COFIR) that they put in place. The aim of COFIR is to introduce a cohort of fellows to the career of clinician-scientists by conducting a longitudinal research project integrated into the curriculum of their clinical fellowship at a level they would not have access to as single individuals...
May 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28449839/statin-prescriptions-for-high-risk-patients-are-increased-by-laboratory-initiated-framingham-risk-scores-a-quality-improvement-initiative
#18
Christopher Naugler, Charles Cook, Louise Morrin, James Wesenberg, Allison A Venner, Norman Campbell, Todd Anderson
Low rates of cardiovascular preventive therapy with statin medications is a significant public health problem in Canada. There is a pressing need for public health interventions to increase the use of statin medications, especially among high-risk patients. In this article, we present the results of a quality assurance pilot program to provide laboratory-reported Framingham Risk Score (FRS) to physicians. This work was performed in a mixed urban and rural setting in southern Alberta. We provided FRSs and, for high-risk patients, statin treatment recommendations in conjunction with laboratory lipid panel requests...
May 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28449838/electrocardiographic-pr-interval-duration-and-cardiovascular-risk-results-from-the-copenhagen-ecg-study
#19
Peter Vibe Rasmussen, Jonas Bille Nielsen, Morten Wagner Skov, Adrian Pietersen, Claus Graff, Bent Lind, Johannes Jan Struijk, Morten Salling Olesen, Stig Haunsø, Lars Køber, Jesper Hastrup Svendsen, Anders Gaarsdal Holst
BACKGROUND: Because of ambiguous reports in the literature, we aimed to investigate the association between PR interval and the risk of all-cause and cardiovascular death, heart failure, and pacemaker implantation, allowing for a nonlinear relationship. METHODS: We included 293,111 individuals, corresponding to one-third of the population in the greater region of Copenhagen. These individuals had a digital electrocardiogram recorded in a general practitioner's core facility from 2001-2011...
May 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28449837/management-strategies-for-statin-associated-muscle-symptoms-how-useful-is-same-statin-rechallenge
#20
Emily T Brennan, Tisha R Joy
BACKGROUND: Statin-associated muscle symptoms (SAMS) are common. Rechallenge with the same statin (same-statin rechallenge) has recently been included as part of a proposed scoring index for diagnosing SAMS, but data regarding tolerability and efficacy of same-statin rechallenge, compared with other strategies, is minimal. In this study we evaluated the tolerability, percent change in low-density lipoprotein cholesterol (LDL-C), and proportion of patients achieving their LDL-C targets among 3 common management strategies-same-statin rechallenge, switching to a different statin (statin switch), and use of nonstatin medications only...
May 2017: Canadian Journal of Cardiology
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