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International Journal of Hyperthermia

Gerben Schooneveldt, H Petra Kok, Akke Bakker, Elisabeth D Geijsen, Coen R N Rasch, Jean J M C H de la Rosette, Maarten C C M Hulshof, Theo M de Reijke, Hans Crezee
PURPOSE: Hyperthermia treatment planning for deep locoregional hyperthermia treatment may assist in phase and amplitude steering to optimize the temperature distribution. This study aims to incorporate a physically correct description of bladder properties in treatment planning, notably the presence of convection and absence of perfusion within the bladder lumen, and to assess accuracy and clinical implications for non muscle invasive bladder cancer patients treated with locoregional hyperthermia...
November 1, 2018: International Journal of Hyperthermia
Xin Liu, Lijuan Xue, Yang Wang, Wei Wang, Jie Tang
OBJECTIVE: To evaluate the feasibility and safety of vaginal delivery after ultrasound-guided high-intensity focused ultrasound (HIFU) ablation treatment for women with uterine fibroids of child-bearing ages. METHODS: A prospective study was conducted on women who underwent ultrasound-guided HIFU therapy for uterine fibroids at the Chinese PLA General Hospital from January 2008 to December 2014. Patients were interviewed yearly to assess their fertility outcomes, including conception method, delivery mode, neonatal outcomes and complications during pregnancy, labor, and delivery...
October 25, 2018: International Journal of Hyperthermia
He Ren, Chao An, Ping Liang, Jie Yu, Zhigang Cheng, Zhiyu Han, Fangyi Liu, Linan Dong, Dongrui Li
OBJECTIVE: To assess the clinical efficiency and feasibility of ultrasound-guided percutaneous microwave ablation (US-PMWA) assisted by a three-dimensional (3D) visualization platform for treating a single large hepatocellular carcinoma (HCC) (diameter ≥5 cm). METHODS: We included 40 patients with a single large HCC from May 2015 to August 2017. Nineteen patients who underwent US-PMWA assisted by a 3D visualization platform formed the 3D group; 21 patients without 3D visualization assistance formed the control group...
October 25, 2018: International Journal of Hyperthermia
Young Song, Do-Hyeong Kim, Tae Dong Kwon, Dong Woo Han, Seung Hyuk Baik, Hwan Ho Jung, Ji Young Kim
INTRODUCTION: Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) predispose to postoperative renal dysfunction. Dexmedetomidine is an α2 adrenoreceptor agonist, which has renoprotective effects after cardiac surgery. OBJECTIVE: To assess the effect of dexmedetomidine on renal function after CRS and HIPEC. MATERIALS: Thirty-eight patients undergoing CRS and HIPEC were randomized to receive dexmedetomidine (dexmedetomidine group, n = 19, loading 1 μg/kg over 20 min followed by infusion at 0...
October 25, 2018: International Journal of Hyperthermia
Yuanqiang Lin, Qiang Wen, Li Guo, Hui Wang, Guoqing Sui, Zhixia Sun
PURPOSE: It is unclear which kind of interventional therapies is the best when treating early-stage hepatocellular carcinoma (HCC). We conducted Bayesian network meta-analyses to compare local tumor progression (LTP), total tumor recurrence and survival rates and to rank the best intervention arm. MATERIALS AND METHODS: A literature search of Pubmed, Embase, Cochrane library and was conducted and randomized controlled trials (RCTs) comparing the outcomes of interventional therapies on early-stage HCC were enrolled...
October 25, 2018: International Journal of Hyperthermia
Lin Zhang, Qiang Li, Chiao-Yin Wang, Po-Hsiang Tsui
Radiofrequency (RF) ablation (RFA) is the most commonly used minimally invasive procedure for thermal ablation of liver tumors. Ultrasound not only provides real-time feedback of the electrode location for RFA guidance but also enables visualization of the tissue temperature. Changes in backscattered energy (CBE) have been widely applied to ultrasound temperature imaging for assessing thermal ablation. Pilot studies have revealed that significant shadowing features appear in CBE imaging and are caused by the electrode and RFA-induced gas bubbles...
October 25, 2018: International Journal of Hyperthermia
Sara L Johnson, Douglas A Christensen, Christopher R Dillon, Allison Payne
In focused ultrasound (FUS) thermal ablation of diseased tissue, acoustic beam and thermal simulations enable treatment planning and optimization. In this study, a treatment-planning methodology that uses the hybrid angular spectrum (HAS) method and the Pennes' bioheat equation (PBHE) is experimentally validated in homogeneous tissue-mimicking phantoms. Simulated three-dimensional temperature profiles are compared to volumetric MR thermometry imaging (MRTI) of FUS sonications in the phantoms, whose acoustic and thermal properties are independently measured...
October 15, 2018: International Journal of Hyperthermia
Zhigang Wei, Xuemei Zhan, Linlin Fan, Xin Ye, Xia Yang, Guanghui Huang, Wenhong Li, Jiao Wang, Xiaoying Han, Min Meng, Yang Ni, Qingyu Li
BACKGROUND: Programmed death-ligand 1 (PD-L1) and CD8+ tumor-infiltrating lymphocytes (TILs) were associated with non-small cell lung cancer (NSCLC). We conducted this study to evaluate the correlation between PD-L1 or CD8+ TILs expression and MWA or survival in advanced NSCLC patients treated with microwave ablation (MWA) plus chemotherapy. METHODS: Previously untreated, pathologically verified advanced NSCLC patients with adequate tissues for the analysis of PD-L1 expression and the presence of CD8+ TILs were retrospectively enrolled...
October 11, 2018: International Journal of Hyperthermia
Roberto Luigi Cazzato, Pierre Auloge, Pierre De Marini, Chloé Rousseau, Jeanie Betsy Chiang, Guillaume Koch, Jean Caudrelier, Pramod Rao, Julien Garnon, Afshin Gangi
INTRODUCTION: Percutaneous image-guided cryo- (CA) and radiofrequency- (RFA) ablations have been widely used in the treatment of painful bone metastases (BM). However, paucity of data is available for the performance of these treatments when used with a curative intent. The aim of this study is to investigate the local progression free-survival (LPFS) after radical percutaneous image-guided ablation of BM in oligometastatic patients, and to identify predictive factors associated with local tumor progression...
October 11, 2018: International Journal of Hyperthermia
Pragya Gupta, Atul Srivastava
The present work is concerned with the numerical investigation of the thermal response of tissue-mimicking biological phantom(s) subjected to high intensity focused ultrasound (HIFU). Simulations have been performed on the 3-dimensional physical domain for two-layered as well as multi-layered medium consisting of water and liver tissue. Local pressure distribution within the body of the phantom has been calculated by solving the complete full-wave nonlinear form of Westervelt equation. The solution of the pressure wave equation has been coupled with Pennes bioheat transfer equation to determine the full field temperature distribution...
October 11, 2018: International Journal of Hyperthermia
Bilgin Keserci, Nguyen Minh Duc
OBJECTIVE: This retrospective study aimed (1) to investigate the magnetic resonance imaging (MRI) features influencing a nonperfused volume ratio (NPVr) ≥ 90% after high-intensity focussed ultrasound (HIFU) ablation of adenomyosis, and (2) to assess the safety, which was defined in terms of adverse events (AEs) and changes in anti-Mullerian hormone (AMH) concentrations, and clinical efficacy, which was defined in terms of adenomyosis volume reduction and symptom improvement at 6 months' follow-up...
October 11, 2018: International Journal of Hyperthermia
Qing Guo, Feng Xu, Zhenzhen Ding, Pan Li, Xinghai Wang, Bulang Gao
OBJECTIVE: To compare the treatment efficacy and safety of high intensity focused ultrasound (HIFU) on its own, HIFU combined with levonorgestrel-releasing intrauterine system (LNG-IUS) and HIFU combined with gonadotropin-releasing hormone agonist (GnRHa). METHOD: Seventy-eight patients with adenomyosis who underwent HIFU treatment were retrospectively analyzed. Among them, 45 patients were treated only with HIFU, 15 patients were treated with HIFU combined with LNG-IUS and 18 patients were treated with HIFU combined with GnRHa...
October 11, 2018: International Journal of Hyperthermia
David Fuentes, Nina M Muñoz, Chunxiao Guo, Urzsula Polak, Adeeb A Minhaj, William J Allen, Michael C Gustin, Erik N K Cressman
OBJECTIVE: A molecular dynamics approach to understanding fundamental mechanisms of combined thermal and osmotic stress induced by thermochemical ablation (TCA) is presented. METHODS: Structural models of fibronectin and fibronectin bound to its integrin receptor provide idealized models for the effects of thermal and osmotic stress in the extracellular matrix. Fibronectin binding to integrin is known to facilitate cell survival. The extracellular environment produced by TCA at the lesion boundary was modelled at 37 °C and 43 °C with added sodium chloride (NaCl) concentrations (0, 40, 80, 160, and 320 mM)...
October 10, 2018: International Journal of Hyperthermia
Brian H H Lang, Yu-Cho Woo, Keith Wan-Hang Chiu
BACKGROUND: We aimed to describe changes in serum thyroglobulin (Tg) and anti-Tg autoantibody shortly following high-intensity focused ultrasound (HIFU) ablation in patients with positive anti-Tg status by comparing them with patients with negative anti-Tg and to correlate them with 6-month nodule shrinkage and treatment success. METHODS: From 2015 to 2017, patients who underwent HIFU ablation of a benign thyroid nodule were analysed. Serum Tg and anti-Tg were checked on treatment day (baseline) and 4 days after treatment...
October 10, 2018: International Journal of Hyperthermia
Hossam Elkhalil, Aiman Alshare, Gal Shafirstein, John Bischof
OBJECTIVE: Laser with 532-nm wavelength (GreenLightTM ) is clinically approved to treat benign prostatic hyperplasia (BPH). However, low rate of tissue ablation and excessive thermal coagulation are shortcomings of this therapy. The goal of this study was to use a mathematical model to identify clinically viable laser settings that have the potential to improve treatment time and outcomes. METHODS: A three-dimensional transient computational model was developed, validated against analytical and experimental results, and utilized to investigate the response of tissues subjected to continuous-wave and pulsed lasers emitting 532-nm light (GreenLightTM laser)...
October 10, 2018: International Journal of Hyperthermia
Marion C Seward, Gregory B Daniel, Jeffrey D Ruth, Nikolaos Dervisis, Ari Partanen, Pavel S Yarmolenko
PURPOSE: Magnetic resonance imaging-guided high-intensity-focused ultrasound (MR-HIFU) is a non-invasive treatment modality that precisely focuses ultrasound energy within a tumour and can be customised to result in a wide range of local bioeffects. The purpose of this study was to determine the feasibility of using MR-HIFU to treat soft tissue sarcoma (STS) in dogs. MATERIALS AND METHODS: Medical records of dogs admitted to the Virginia-Maryland College of Veterinary Medicine from 1 January 2012 to 31 December 2016 were searched for a diagnosis of sarcoma with available cross-sectional imaging of the tumour (MRI or CT)...
October 10, 2018: International Journal of Hyperthermia
Amy L Kimball, Patrick M McCue, Michael A Petrie, Richard K Shields
AIM: Exercise modulates glucose tolerance and homeostasis in both healthy and diabetic individuals. Heat stress is a fundamental element of exercise. The acute glycemic response and alterations in glucose clearance following whole body passive heat stress in the absence of muscle activity has yet to be examined in humans. Knowledge of this relationship may prove useful, particularly in populations with compromised glucoregulation from reduced activity. PURPOSE: To determine insulin/glucose levels before and after an acute bout of heat stress in healthy, lean individuals and examine the effects of whole body heat stress (WBHS) and exercise on acute glucose tolerance in an expanded cohort...
October 10, 2018: International Journal of Hyperthermia
Chang-Soon Lee, Jae Young Lee, Soohan Ro, Seungeun Choi, Jee Youn Moon
BACKGROUND: High-intensity focused ultrasound (HIFU) is a noninvasive thermodestructive procedure targeting internal organs with concentrated sonification energy that may cause pain. We aimed to compare the effectiveness of epidural analgesia (EA) and monitored anesthesia care (MAC) in HIFU treatment of uterine adenomyosis. MATERIALS AND METHODS: Sixty-eight patients were included in this case-control study. Thirty-seven patients underwent MAC; 31 patients underwent fluoroscope-guided epidural analgesia...
October 10, 2018: International Journal of Hyperthermia
Takamasa Hashizaki, Yukihide Nishimura, Kenzo Teramura, Yasunori Umemoto, Manabu Shibasaki, C A Leicht, Ken Kouda, Fumihiro Tajima
OBJECTIVES: Passive rise in core body temperature achieved by head-out hot water immersion (HHWI) results in acute increases in serum interleukin (IL)-6 but no change in plasma adrenaline in patients with cervical spinal cord injury (CSCI). The purpose of the present study was to determine the mechanism of heat stress-induced increase in serum IL-6. SETTING: A cross-sectional study. METHODS: The study subjects were nine with CSCI, ten with thoracic and lumbar spinal cord injury (TLSCI) and eight able-bodied (AB) subjects...
October 10, 2018: International Journal of Hyperthermia
G Schooneveldt, H P Kok, A Bakker, E D Geijsen, M C C M Hulshof, T M de Reijke, J Crezee
PURPOSE: Loco-regional hyperthermia combined with mitomycin C is used for treatment of nonmuscle invasive bladder cancer (NMIBC). Air pockets may be present in the bladder during treatment. The aim of this study is to quantify the effect of air pockets on the thermal dose of the bladder. METHODS: We analysed 16 patients treated for NMIBC. Loco-regional hyperthermia was performed with the in-house developed 70 MHz AMC-4 hyperthermia device. We simulated treatments with the clinically applied device settings using Plan2Heat (developed in-house) including the air pockets delineated on CT scans made following treatment, and with the same volume filled with urine...
October 10, 2018: International Journal of Hyperthermia
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