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International Journal of Hyperthermia

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https://www.readbyqxmd.com/read/28931333/hyperthermia-treatment-planning-guided-applicator-selection-for-sub-superficial-head-and-neck-tumors-heating
#1
Tomas Drizdal, Margarethus M Paulides, Netteke van Holthe, Gerard C van Rhoon
PURPOSE: In this study, we investigated the differences in hyperthermia treatment (HT) quality between treatments applied with different hyperthermia systems for sub-superficial tumours in the head and neck (H&N) region. MATERIALS AND METHODS: In 24 patients, with a clinical target volume (CTV) extending up to 6 cm from the surface, we retrospectively analysed the predicted HT quality achievable by two planar applicator arrays or one phased-array hyperthermia system...
October 16, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/29025325/versatility-of-targeted-antibiotic-loaded-gold-nanoconstructs-for-the-treatment-of-biofilm-associated-bacterial-infections
#2
Daniel G Meeker, Tengjiao Wang, Walter N Harrington, Vladimir P Zharov, Sarah A Johnson, Samir V Jenkins, Stephanie E Oyibo, Christopher M Walker, Weston B Mills, Mark E Shirtliff, Karen E Beenken, Jingyi Chen, Mark S Smeltzer
BACKGROUND: We previously demonstrated that a photoactivatable therapeutic approach employing antibiotic-loaded, antibody-conjugated, polydopamine (PDA)-coated gold nanocages (AuNCs) could be used for the synergistic killing of bacterial cells within a biofilm. The approach was validated with a focus on Staphylococcus aureus using an antibody specific for staphylococcal protein A (Spa) and an antibiotic (daptomycin) active against Gram-positive cocci including methicillin-resistant S...
October 12, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/29025324/the-effects-of-head-cooling-on-brain-function-during-passive-hyperthermia-an-fmri-study
#3
Yan Xue, Li Li, Shaowen Qian, Kai Liu, Xiaohong Joe Zhou, Bo Li, Qingjun Jiang, Zhuanzhuan Wu, Lexia Du, Gang Sun
PURPOSE: To investigate the effect of head-cooling on resting-state spontaneous brain activity during passive hyperthermia. METHODS: An environmental heat exposure was simulated on 16 healthy men under a normal control condition (NC) at 25°C and two hot conditions at 50°C with (HHC) and without (HOT) keeping the head cool, respectively. Resting-state functional MRI (fMRI) data were acquired under each condition and the values of amplitude low frequency fluctuations (ALFF) and z functional connectivity (zFC) were computed to examine regional activity and functional integration, respectively...
October 12, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/29025295/ultrasonography-guided-percutaneous-microwave-ablation-for-large-hepatic-cavernous-hemangiomas
#4
Fangyi Liu, Xiaoling Yu, Ping Liang, Zhigang Cheng, Zhiyu Han, Jie Yu
PURPOSE: To evaluate the efficacy and safety of ultrasound-guided percutaneous microwave ablation (MWA) for large hepatic cavernous hemangiomas (HCHs) with ablation of the feeding artery and aspiration of blood from hemangioma simultaneously. MATERIALS AND METHODS: From January 2011 to December 2016, 40 patients (29 females, 11male; average age 43.25±7.65 years) with 42 giant hepatic hemangiomas (mean diameter7.02±1.55cm, range4.1-10.8 cm) were treated with image-guided percutaneous MWA with ablation of the feeding artery and aspiration of blood from hemangioma simultaneously...
October 12, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28982246/application-of-microwave-ablation-in-the-emergent-control-of-intraoperative-life-threatening-tumor-hemorrhage-during-hepatic-surgeries
#5
Haoming Zhou, Jindao Wu, Wei Ling, Deming Zhu, Ling Lu, Xuehao Wang, Liyong Pu, Lianbao Kong
PURPOSE: This study was designed to evaluate the efficacy and safety of microwave ablation (MWA) in the treatment of intraoperative life-threatening tumor hemorrhage during hepatic surgeries. METHODS: Three cases of MWA application in the emergent control of life-threatening hepatic tumor hemorrhage were analyzed and reported. RESULTS: Satisfactory hemostasis for hepatic tumor rupture was achieved by MWA in all three cases. No major complications, such as post-operative hemorrhage, bile duct injury, liver abscess, colon perforation, skin burns, tumor seeding or renal dysfunction, were identified...
October 5, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28978237/exploring-the-trend-in-referrals-for-consideration-of-crs-and-hipec-to-understand-the-attitudes-of-clinicians-in-the-development-of-a-national-cancer-centre-program-in-peritoneal-disease
#6
Weining Wang, Grace Hwei Ching Tan, Thakshayeni Skanthakumar, Claramae Shulyn Chia, Khee Chee Soo, Melissa Ching Ching Teo
INTRODUCTION: Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) improve survival in selected patients with peritoneal metastases. However, only some patients who are potentially eligible for the procedure are considered and referred to the appropriate surgical department. By studying the trends of patients being considered for CRS and HIPEC in our center, we hope to better understand the demographics of our patient cohort and the attitudes of physicians involved towards CRS and HIPEC...
October 4, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28974122/activation-of-hypoxia-inducible-factor-1-in-rat-brain-after-perinatal-anoxia-role-of-body-temperature
#7
Hanna Kletkiewicz, Malwina Hyjek, Krzysztof Jaworski, Anna Nowakowska, Justyna Rogalska
Transcriptional hypoxia-inducible factor-1α (HIF-1α) plays the fundamental role in adaptive processes in response to hypoxia. Specific HIF-1α target genes are involved in glycolysis, erythropoiesis and angiogenesis to promote survival. In our previous study we have demonstrated that naturally low body temperature of newborn rats protects them against damage due to perinatal hypoxia. Therefore, our experiments aimed at checking the effects of body temperature during simulated perinatal anoxia on subsequent changes of expression of HIF-1α and its specific target genes such as VEGF and EPO in the rat brain...
October 4, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28974121/a-review-of-immune-therapy-in-cancer-and-a-question-can-thermal-therapy-increase-tumor-response
#8
Joan M C Bull
Immune therapy is a successful cancer treatment coming into its own. This is because checkpoint molecules, adoptive specific lymphocyte transfer, and CAR-T therapy are able to induce more responses and more durable responses in an increasing number of malignancies compared to chemotherapy. In addition, immune therapies are able to treat bulky disease, whereas standard cytotoxic therapies cannot treat large tumor burdens. Checkpoint inhibitor monoclonal antibodies are becoming widely used in the clinic; and although more complex, adoptive lymphocyte transfer and CAR-T therapies show promise...
October 4, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28974120/the-oncologic-results-of-cryoablation-in-prostate-cancer-patients-with-bone-metastases
#9
Tongguo Si, Zhi Guo, Xueling Yang, Weihao Zhang, Wenge Xing
OBJECTIVE: To explore the role of whole gland cryoablation plus ADT in prostate cancer (PCa) with bone metastases compared with ADT treatment alone in metastatic PCa. METHODS: A total of 30 patients with biopsy proven PCa with bone metastases underwent cryoablation and ADT treatment. The control group consisted of 30 men who were initially treated with ADT only and who were followed until progression, development of castration resistant PCa or death. Patients were pair-matched for age, PSA level, clinical stage, preoperative biopsy Gleason score, and bone metastases...
October 4, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28974113/combined-radiofrequency-ablation-and-ethanol-injection-versus-repeat-hepatectomy-for-elderly-patients-with-recurrent-hepatocellular-carcinoma-after-initial-hepatic-surgery
#10
Shuling Chen, Zhenwei Peng, Han Xiao, Manxia Lin, Zebin Chen, Chunlin Jiang, Wenjie Hu, Xiaoyan Xie, Longzhong Liu, Baogang Peng, Ming Kuang
PURPOSE: To retrospectively compare the efficacy and safety of combined radiofrequency ablation and percutaneous ethanol injection (RFA-PEI) with repeat hepatectomy for elderly patients with initial recurrent hepatocellular carcinoma (HCC) after hepatic surgery. METHODS: From January 2009 to June 2015, 105 elderly patients (≥ 70 years) who underwent RFA-PEI (n = 57) or repeated hepatectomy (n = 48) for recurrent HCC ≤ 5.0 cm were included in the study...
October 4, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28967270/correction-to-tan-et-al-diagnostic-and-therapeutic-laparoscopy-in-assessment-and-management-of-patients-with-appendiceal-neoplasms
#11
(no author information available yet)
No abstract text is available yet for this article.
October 2, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28854826/high-intensity-focused-ultrasound-in-the-treatment-of-breast-fibroadenomata-hifu-f-trial
#12
M C L Peek, M Ahmed, J Scudder, R Baker, P Charalampoudis, S E Pinder, M Douek
BACKGROUND: High-intensity focussed ultrasound (HIFU) is a non-invasive ablative technique utilising the application of high frequency ultrasound (US) pressure waves to cause tissue necrosis. This emerging technology is currently limited by prolonged treatment times. The aim of the HIFU-F trial was to perform circumferential HIFU treatment as a means of shortening treatment times. METHODS: A prospective trial was set up to treat 50 consecutive patients ≥18 years of age...
October 2, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28954558/two-questions-about-the-analysis-and-interpretation-of-randomized-trials
#13
Greg Samsa, Megan Neely
This non-technical tutorial focus on two questions about the analysis of data from randomized trials. Which is the more appropriate analysis of data from a randomized trial - an unadjusted analysis or an adjusted one? When a result is not statistically significant is it nevertheless appropriate to comment on its direction?
September 27, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28954551/heat-stress-induced-ligand-independent-met-and-egfr-signaling-in-hepatocellular-carcinoma
#14
Scott M Thompson, Danielle E Jondal, Kim A Butters, Bruce E Knudsen, Jill L Anderson, Matthew P Stokes, Xiaoying Jia, Joseph P Grande, Lewis R Roberts, Matthew R Callstrom, David A Woodrum
PURPOSE: The aims of the present study were two-fold: first, to test the hypothesis that heat stress induces MET and EGFR signaling in hepatocellular carcinoma (HCC) cells and inhibition of this signaling decreases HCC clonogenic survival; and second, to identify signaling pathways associated with heat-stress induced MET signaling. MATERIALS AND METHODS: MET(+) and EGFR(+) HCC cells were pre-treated with inhibitors to MET, EGFR, PI3K/mTOR or vehicle and subjected to heat stress or control ± HGF or EGF growth factors and assessed by colony formation assay, Western blotting and/or quantitative mass spectrometry...
September 27, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28927330/thalamocortical-neural-responses-during-hyperthermia-a-resting-state-functional-mri-study
#15
Jing Zhang, Shaowen Qian, Qingjun Jiang, Guanzhong Gong, Kai Liu, Bo Li, Yong Yin, Gang Sun
The neural responses during hyperthermia, once thought of as simple physiological processes (e.g. thermal sensation and regulation), have now been recognized involving more cognitive processes, which would be highly of importance to the management of those occupations during heavy heat exposure. Previous studies have demonstrated altered activity in localized subcortical clusters for thermal sensation and regulation, as well as cortical-cortical activity for behavioral tasks during hyperthermia. However, the involvement of cortical-subcortical activity during hyperthermia has not been investigated...
September 19, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28893108/comparative-efficacy-evaluation-of-catheter-intraperitoneal-chemotherapy-normothermic-and-hyperthermic-chemoperfusion-in-a-rat-model-of-ascitic-ovarian-cancer
#16
V G Bespalov, I K Alvovsky, G V Tochilnikov, A N Stukov, E A Vyshinskaya, A L Semenov, I N Vasilyeva, O A Belyaeva, G S Kireeva, K Y Senchik, J D Von, L A Krasilnikova, V A Alexandrov, N N Khromov-Borisov, D A Baranenko, A M Belyaev
OBJECTIVES: The choice of an optimal administration route for intraperitoneal (IP) chemotherapy and a suitable chemotherapeutic regime in the treatment of ovarian cancer remains a controversy. We investigated survival outcomes according to catheter intraperitoneal chemotherapy (CIPC), normothermic and hyperthermic chemoperfusion (NIPEC and HIPEC) with cytostatic drugs dioxadet and cisplatin in rats with transplantable ascitic ovarian cancer. METHODS: Ascitic liquid containing 1·10(7) tumor cells was inoculated to female Wistar rats and 48 hours after rats received dioxadet and cisplatin at the maximum tolerated doses...
September 11, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28891354/brca2-protects-mammalian-cells-from-heat-shock
#17
Yosuke Nakagawa, Atsuhisa Kajihara, Akihisa Takahashi, Akiho S Murata, Masaya Matsubayashi, Soichiro S Ito, Ichiro Ota, Takahiko Nakagawa, Masatoshi Hasegawa, Tadaaki Kirita, Takeo Ohnishi, Eiichiro Mori
PURPOSE: Heat shock induces DNA double-strand breaks (DSBs) in mammalian cells. Mammalian cells are capable of repairing DSBs by utilising the homologous recombination (HR) pathway. Breast cancer susceptibility gene 2 (BRCA2) is known to regulate the HR pathway. Here, we investigate the role of BRCA2 in repairing DNA damage induced by heat shock. MATERIALS AND METHODS: Chinese hamster lung fibroblast cell lines and human tongue squamous cell carcinoma SAS cells were used...
September 10, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28877609/cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-for-the-treatment-of-advanced-epithelial-and-recurrent-ovarian-carcinoma-a-single-center-experience
#18
Maja J Pavlov, Miljan S Ceranic, Stojan M Latincic, Predrag V Sabljak, Dragutin M Kecmanovic, Paul H Sugarbaker
BACKGROUND: With standard treatment of epithelial ovarian cancer (EOC), prognosis is very poor. The aim of this study is to show early and late results in patients who underwent cytoreductive surgery and intraperitoneal chemotherapy. PATIENTS AND METHODS: This was a retrospective single centre study. All patients with advanced and recurrent ovarian cancer treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) or modified early postoperative intraperitoneal chemotherapy (EPIC) were included in the study...
September 7, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28877612/the-role-of-mri-in-the-early-evaluation-of-lung-microwave-ablation
#19
Andrei Roman, Benjamin Kaltenbach, Tatjana Gruber-Rouh, Nagy N Naguib, Thomas J Vogl, Nour-Eldin A Nour-Eldin
PURPOSE: To retrospectively investigate the role of a contrast enhanced MRI (ceMRI) performed 24 hours after a microwave ablation (MWA) of the lung, in predicting local tumor progression (LTP) and detecting complications compared to an unenhanced CT Material and methods: Forty-nine patients that underwent MWA of 77 lung metastases between 2008 and 2015 were included. All patients received an unenhanced chest CT and a ceMRI (including T2 and ceT1) 24h after MWA. The conspicuities of the peripheral rim and of the ablated tumor were scored using 1-3 scales and compared between examinations...
September 6, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28871860/effects-of-variable-power-on-tissue-ablation-dynamics-during-magnetic-resonance-guided-laser-induced-thermal-therapy-with-the-visualase-system
#20
Sean M Munier, Eric L Hargreaves, Nitesh V Patel, Shabbar F Danish
PURPOSE: Magnetic resonance-guided laser-induced thermal therapy (MRgLITT) is a minimally invasive procedure used to treat various intracranial pathologies. This study investigated the effects of variable power on maximal estimated thermal damage during ablation and duration required to reach maximal ablation. MATERIALS/METHODS: All ablations were performed using the Visualase Thermal Therapy System (Medtronic Inc., Minneapolis, Minnesota), which uses a 980-nm diffusing tip diode laser...
September 5, 2017: International Journal of Hyperthermia
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