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International Journal of Hyperthermia

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https://www.readbyqxmd.com/read/28641499/a-comprehensive-model-for-heat-induced-radio-sensitization
#1
Sarah Catharina Brüningk, Jannat Ijaz, Ian Rivens, Simeon Nill, Gail Ter Haar, Uwe Oelfke
Combined radiotherapy (RT) and hyperthermia (HT) treatments may improve treatment outcome by heat induced radio-sensitization. We propose an empirical cell survival model (AlphaR model) to describe this multimodality therapy. The model is motivated by the observation that heat induced radio-sensitization may be explained by a reduction in the DNA damage repair capacity of heated cells. We assume that this repair is only possible up to a threshold level above which survival will decrease exponentially with dose...
June 23, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28641464/ultrasound-guided-hydrodissection-for-assisting-percutaneous-microwave-ablation-of-renal-cell-carcinomas-adjacent-to-intestinal-tracts-a-preliminary-clinical-study
#2
Zhigang Cheng, Xiaoling Yu, Zhiyu Han, Fangyi Liu, Jie Yu, Ping Liang
PURPOSE: To evaluate the safety and efficacy of the clinical application of hydrodissection under ultrasound (US) guidance for assisting percutaneous microwave ablation (MWA) for the treatment of renal cell carcinomas (RCCs) adjacent to the intestinal tract. MATERIALS AND METHODS: From April 2014 to December 2016, clinical data from 24 patients with 25 RCCs were retrospectively analysed. Percutaneous MWA under the assistance of US-guided hydrodissection were performed to treat RCCs with a mean maximal diameter of 3...
June 22, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28633613/thermal-effects-on-cognition-a-new-quantitative-synthesis
#3
José Ignacio López-Sánchez, P A Hancock
There is little doubt that increases in thermal load beyond the thermo-neutral state prove progressively stressful to all living organisms. Increasing temperatures across the globe represent in some locales, and especially for outdoors workers, a significant source of such chronic load increase. However, increases in thermal load affect cognition as well as physical work activities. Such human cognition has perennially been viewed as the primary conduit through which to solve many of the iatrogenic challenges we now face...
June 20, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28633580/platinum-agents-and-mitomycin-c-specific-complications-in-cytoreductive-surgery-crs-and-hyperthermic-intraperitoneal-chemotherapy-hipec
#4
Grace Hwei Ching Tan, Nicholas B Shannon, Claramae Shulyn Chia, Khee Chee Soo, Melissa Ching Ching Teo
INTRODUCTION: Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) have been found to prolong survival in patients with peritoneal disease but is associated with significant morbidity. We evaluate the perioperative complications and the association with the chemotherapy agent used for HIPEC. METHODS: Retrospective analysis of a prospectively collected database of CRS-HIPEC cases between April 2001 and February 2016 was performed. Patients were stratified by the chemotherapy used, and perioperative complications were compared...
June 20, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28554240/numerical-analysis-of-thermal-impact-of-intramyocardial-capillary-blood-flow-during-radiofrequency-cardiac-ablation
#5
Juan J Pérez, Ana González-Suárez, Enrique Berjano
PURPOSE: The thermal effect of the intramyocardial blood perfusion on the size of lesions created by radiofrequency cardiac ablation (RFCA) has not been adequately studied to date. Our objective was to assess the impact of including this phenomenon in RFCA computer modelling in terms of the thermal lesion depth created. METHODS: A computer model was built and computer simulations were conducted to assess the effect of including the blood perfusion term in the bioheat equation...
June 18, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28545303/a-thermoelastic-deformation-model-of-tissue-contraction-during-thermal-ablation
#6
Chang Sub Park, Cong Liu, Sheldon K Hall, Stephen J Payne
PURPOSE: Thermal ablation is an energy-based ablation technique widely used during minimally invasive cancer treatment. Simulations are used to predict the dead tissue post therapy. However, one difficulty with the simulations is accurately predicting the ablation zone in post-procedural images due to the contraction of tissue as a result of exposure to elevated temperatures. MATERIALS AND METHODS: A mathematical model of the thermoelastic deformation for an elastic isotropic material was coupled with a three state thermal denaturation model to determine the contraction of tissue during thermal ablation...
June 14, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28610551/passive-cooling-of-cutaneous-and-subcutaneous-tissues-using-phase-changing-materials-feasibility-study-using-a-numerical-model
#7
Ricardo Romero-Méndez, Francisco G Pérez-Gutiérrez, Joseph J Musacchia, Walfre Franco
In many dermatological applications, lowering the temperature of skin and maintaining specific temperatures for extended periods of time are fundamental requirements for treatment; for example, in targeting adipose tissue and managing cutaneous pain. In this work we investigate the feasibility of using phase changing materials (PCMs) as an alternative passive, open-loop, heat extraction method for cooling cutaneous and subcutaneous tissues. We used a finite difference parametric approach to model the spatial and temporal progression of the heat transferred from the skin to a PCM in contact with the skin surface...
June 13, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28610455/non-fourier-thermal-transport-induced-structural-hierarchy-and-damage-to-collagen-ultrastructure-subjected-to-laser-irradiation
#8
Nilamani Sahoo, Arunn Narasimhan, Purbarun Dhar, Sarit Kumar Das
Comprehending the mechanism of thermal transport through biological tissues is an important factor for optimal ablation of cancerous tissues and minimising collateral tissue damage. The present study reports detailed mapping of the rise in internal temperature within the tissue mimics due to NIR (1064 nm) laser irradiation, both for bare mimics and with gold nanostructures infused. Gold nanostructures such as mesoflowers and nano spheres have been synthesized and used as photothermal converters to enhance the temperature rise, resulting in achieving the desired degradation of malignant tissue in targeted region...
June 13, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28605996/in-vitro-exposure-of-bull-sperm-cells-to-dmsa-coated-maghemite-nanoparticles-does-not-affect-cell-functionality-or-structure
#9
Denise Ferreira Caldeira, Fernanda Paulini, Renata Carvalho Silva, Ricardo Bentes de Azevedo, Carolina Madeira Lucci
Magnetic nanoparticles can be used in different areas of biology. It is therefore important to know the effects of such nanomaterials on germline cells as they may traverse the blood-testis barrier. This work aimed to evaluate the response of bull sperm after exposure to a magnetic fluid containing DMSA-coated maghemite nanoparticles (MNP-DMSA) in order to determine nanotoxicity. Bull sperm was incubated with MNP-DMSA at final concentrations of 0.06, 0.03 or 0.015 mg Fe/mL. Sperm kinetics, plasma membrane integrity and acrosome reaction were evaluated over a four-hour incubation period...
June 12, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28605985/diagnostic-and-therapeutic-laparoscopy-in-assessment-and-management-of-patients-with-appendiceal-neoplasms
#10
Grace Hwei Ching Tan, Tushar Shamji, Akash Mehta, Kandiah Chandrakumaran, Sanjeev Dayal, Faheez Mohamed, Normal J Carr, Babtunde Rowaiye, Tom Cecil, Rendan J Moran
INTRODUCTION: Radiological imaging often underestimates the extent of low volume peritoneal disease. The benefit of laparoscopy in assessing peritoneal metastases from colorectal and gastric cancer is accepted, but is inconclusive for appendiceal malignancy. We report our experience of diagnostic (DL) and therapeutic laparoscopy (TL) in patients with appendiceal tumours to determine indications and role in assessment and management. METHODS: A retrospective review of a National Peritoneal Malignancy Centre's prospectively maintained database was performed...
June 12, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28605946/design-and-characterization-of-a-phased-antenna-array-for-intact-breast-hyperthermia
#11
Sergio Curto, Aleix Garcia-Miquel, Minyoung Suh, Neus Vidal, Jose M Lopez-Villegas, Punit Prakash
PURPOSE: Currently available hyperthermia technology is not well suited to treating cancer malignancies in the intact breast. This study investigates a microwave applicator incorporating multiple patch antennas, with the goal of facilitating controllable power deposition profiles for treating lesions at diverse locations within the intact breast. MATERIALS AND METHODS: A 3D-computational model was implemented to assess power deposition profiles with 915 MHz applicators incorporating a hemispheric groundplane and configurations of 2, 4, 8, 12, 16 and 20 antennas...
June 12, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28605944/a-comparison-of-laser-with-radiofrequency-ablation-for-the-treatment-of-benign-thyroid-nodules-a-propensity-score-matching-analysis
#12
Claudio Maurizio Pacella, Giovanni Mauri, Roberto Cesareo, Valerio Paqualini, Roberto Cianni, Pierpaolo De Feo, Giovanni Gambelunghe, Bruno Raggiunti, Doris Tina, Maurilio Deandrea, Pier Paolo Limone, Alberto Mormile, Massimo Giusti, Silvia Oddo, Gaetano Achille, Enrico Di Stasio, Irene Misischi, Enrico Papini
PURPOSE: To compare technique efficacy and safety of laser ablation (LA) and radiofrequency ablation (RFA) in treatment of benign thyroid nodules. MATERIALS AND METHODS: Institutional review board approval was obtained, and patients' consent was waived. 601 nodules were treated from May 2009 to December 2014 at eight centres, 449 (309 females, age 57 ± 14 years) with LA and 152 (107 females, age 57 ± 14 years) with RFA. A matched cohort composed of 138 patients from each group was selected after adjustment with propensity score matching...
June 12, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28597707/ct-guided-radiofrequency-ablation-of-spinal-osteoblastoma-treatment-and-long-term-follow-up
#13
Francesco Arrigoni, Antonio Barile, Luigi Zugaro, Eva Fascetti, Marcello Zappia, Luca Brunese, Carlo Masciocchi
OBJECTIVE: Osteoblastoma (OB) is a painful, rare, benign bone tumour usually observed in young populations, and this condition involves the spine in up to one-third of cases. We sought to focus on the minimally invasive treatment of spinal OB with radiofrequency ablation (RFA) under computed tomography (CT) guidance. When performed near the spinal cord, surgery can lead to instability of the spine, sometimes requiring additional interventions to stabilise the segments involved, and can cause the precocious onset of arthrosis or other degenerative diseases...
June 9, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28595499/thermal-diffusivity-and-perfusion-constants-from-in-vivo-mr-guided-focused-ultrasound-treatments-a-feasibility-study
#14
Christopher R Dillon, Viola Rieke, Pejman Ghanouni, Allison Payne
PURPOSE: This study investigates the feasibility of non-invasively determining thermal diffusivity (α) and the Pennes perfusion parameter (w) from preclinical and clinical magnetic resonance-guided focused ultrasound (MRgFUS) temperature data. MATERIALS AND METHODS: Pre-clinical MRgFUS experiments were performed in rabbit muscle (N = 3, 28 sonications) using three-dimensional MR thermometry. 8 sonications were made in a clinical QA phantom with two-dimensional thermometry...
June 8, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28540835/influence-of-temperature-on-cerebellar-metabolite-levels
#15
Zhicheng Yang, Jun Li
OBJECTIVE: The cerebellum is extremely sensitive to heat-induced injury because of the abundance of Purkinje cells. This study explored the influence of temperature on cerebellar metabolite levels by magnetic resonance spectroscopy (MRS). MATERIALS AND METHODS: Ten healthy volunteers were recruited to undergo a MRS examination in the summer and winter. Twenty-four ordinary patients with fever underwent the same examination during fever and after recovery. All MR spectras were recorded from the cerebellum...
June 7, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28540836/vocal-cord-paresis-following-single-session-high-intensity-focused-ablation-hifu-treatment-of-benign-thyroid-nodules-incidence-and-risk-factors
#16
Brian H H Lang, Yu-Cho Woo, Keith Wan-Hang Chiu
BACKGROUND: Vocal cord paresis (VCP) may occur following high intensity focused ultrasound (HIFU) of thyroid nodules. We hypothesised its occurrence relates to the distance of the focus point (FP) of the HIFU beams from the recurrent laryngeal nerve (RLN) and the thermal power that this point received. Their relationships were examined. METHODS: One hundred and three patients who underwent HIFU for symptomatic benign thyroid nodule from October 2015 to March 2017 were analysed...
June 6, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28540834/the-cryo-thermal-therapy-induced-il-6-rich-acute-pro-inflammatory-response-promoted-dcs-phenotypic-maturation-as-the-prerequisite-to-cd4-t-cell-differentiation
#17
Kun Liu, Kun He, Ting Xue, Ping Liu, Lisa X Xu
In our previous studies, a novel tumour therapeutic modality of the cryo-thermal therapy has been developed leading to long-term survival in 4T1 murine mammary carcinoma model. The cryo-thermal therapy induced the strong acute inflammatory response and IL-6 was identified in an acute profile. In this study, we found that the cryo-thermal therapy triggered robust acute inflammatory response with high expression of IL-6 locally and systemically. The phenotypic maturation of dendritic cells (DCs) was induced by acute IL-6 following the treatment...
June 6, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28565997/safety-of-radiofrequency-ablation-of-benign-thyroid-nodules-and-recurrent-thyroid-cancers-a-systematic-review-and-meta-analysis
#18
Sae Rom Chung, Chong Hyun Suh, Jung Hwan Baek, Hye Sun Park, Young Jun Choi, Jeong Hyun Lee
OBJECTIVE: We performed a systematic review and meta-analysis to evaluate the safety of radiofrequency ablation (RFA) for the treatment of benign thyroid nodules and recurrent thyroid cancers. MATERIALS AND METHODS: Ovid-MEDLINE, EMBASE, and Library of Cochrane databases were searched up to July 12, 2016 for studies on the safety of RFA for treating benign thyroid nodules or recurrent thyroid cancers. Pooled proportions of overall and major complications were assessed using random-effects modeling...
June 1, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28562119/cytoreductive-surgery-with-hyperthermic-intraperitoneal-chemotherapy-for-peritoneal-malignancy-preliminary-results-of-a-multi-disciplinary-teamwork-model-in-asia
#19
Ting-Yao Wang, Chao-Yu Chen, Chang-Hsien Lu, Min-Chi Chen, Li-Wen Lee, Tzu-Hao Huang, Meng-Chiao Hsieh, Chih-Jung Chen, Chung-Ming Yu, Huei-Chieh Chuang, Tzu-Ting Liao, Chih-Wen Tseng, Wen-Shih Huang
BACKGROUND: Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) is an emerging surgical procedure for peritoneal carcinomatosis (PC). CRS/HIPEC is a complicated treatment that requires multi-disciplinary teamwork (MDT) which may be lacking when establishing a CRS/HIPEC program. Herein, we report our preliminary treatment outcomes with the early implementation of an MDT model for CRS/HIPEC. METHODS: From April 2015 to December 2016, 45 patients with a diagnosis of PC who received CRS/HIPEC were reviewed retrospectively in a single institution in Taiwan...
May 31, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28554226/radiofrequency-ablation-using-a-multiple-electrode-switching-system-for-hepatocellular-carcinoma-within-the-milan-criteria-long-term-results
#20
Yunhua Tan, Jiayun Jiang, Qiang Wang, Shixiang Guo, Kuansheng Ma, Ping Bie
PURPOSE: To assess the long-term outcome of 516 consecutive patients treated with multiple-electrode switching system (MESS) radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC) that met the Milan criteria. MATERIALS AND METHODS: We performed 522 MESS RFAs on 516 patients from December 2006 to June 2011. A total of 956 tumours that met the Milan criteria with an average diameter of 2.64 cm (range, 0.9-4.6 cm) were treated with MESS RFA. Ultrasonic contrast and serum α-fetoprotein (AFP) were measured every 2 months during the first postoperative year and every 4 months thereafter...
May 29, 2017: International Journal of Hyperthermia
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