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International Journal of Hyperthermia

Sae Rom Chung, Jung Hwan Baek, Young Jun Choi, Jeong Hyun Lee
OBJECTIVE: The aim of this study was to introduce a management strategy for nerve damage occurring during radiofrequency ablation (RFA). METHODS: From January 2016 to October 2017, 17 patients who experienced the symptoms of nerve damage during RFA were enrolled in this study. If damage to nerves was suspected during RFA, ablation was stopped immediately, and a cold solution of 5% dextrose was injected directly into the space where the nerves were located until symptoms improved...
January 14, 2019: International Journal of Hyperthermia
Brian Hh Lang, Yu-Cho Woo, Keith Wan-Hang Chiu
BACKGROUND: High intensity focused ultrasound (HIFU) ablation is a promising treatment for benign thyroid nodules but because bleeding complications can occur following any intervention to the thyroid gland, the safety and efficacy of HIFU ablation were evaluated in patients who continued taking an anti-coagulation or anti-platelet agent during treatment. METHODS: From 2015 to 2017, 303 patients who underwent a single-session ablation for a benign thyroid nodule were analyzed...
December 16, 2018: International Journal of Hyperthermia
Roberto Negro, Gabriele Greco
PURPOSE: Patients with toxic adenomas (TAs) that are too large to undergo radioactive iodine (RAI) treatment aimed at resolving hyperthyroidism and/or relieving mechanical pressure symptoms are referred to surgery. This prospective study aimed to assess the outcomes of combining laser ablation (LA) plus RAI vs lobectomy to treat large TAs in terms of clinical efficacy and the health-related quality of life (HRQoL). PATIENTS AND METHODS: Patients with TAs of volumes greater than 20 mL and a calculated therapeutic activity exceeding 600 Mbq were randomly assigned to undergo LA + RAI (Group A) or lobectomy (Group B)...
December 16, 2018: International Journal of Hyperthermia
Sri Kamal Kandala, Eleni Liapi, Louis L Whitcomb, Anilchandra Attaluri, Robert Ivkov
PURPOSE: To study, with computational models, the utility of power modulation to reduce tissue temperature heterogeneity for variable nanoparticle distributions in magnetic nanoparticle hyperthermia. METHODS: Tumour and surrounding tissue were modeled by elliptical two- and three-dimensional computational phantoms having six different nanoparticle distributions. Nanoparticles were modeled as point heat sources having amplitude-dependent loss power. The total number of nanoparticles was fixed, and their spatial distribution and heat output were varied...
December 12, 2018: International Journal of Hyperthermia
Chenchen Bing, Pratik Patel, Robert M Staruch, Sumbul Shaikh, Joris Nofiele, Michelle Wodzak Staruch, Debra Szczepanski, Noelle S Williams, Theodore Laetsch, Rajiv Chopra
Thermosensitive liposomal doxorubicin (LTSL-Dox) combined with mild hyperthermia enhances the localized delivery of doxorubicin (Dox) within a heated region. The optimal heating duration and the impact of extended heating on systemic drug distribution are unknown. Here we evaluated local and systemic Dox delivery with two different mild hyperthermia durations (42 °C for 10 or 40 minutes) in a Vx2 rabbit tumor model. We hypothesized that longer duration of hyperthermia would increase Dox concentration in heated tumors without increasing systemic exposure...
December 12, 2018: International Journal of Hyperthermia
Si Qin, Guang-Jian Liu, Meijin Huang, Jun Huang, Yanxin Luo, Yanling Wen, Yimin Wang, Limei Chen
PURPOSE: To investigate the clinical effectiveness and safety of ultrasound (US)-guided percutaneous microwave ablation (MWA) for colorectal liver metastasis (CRLM) and evaluate the influencing factors of local efficacy. METHODS: From January 2013 to January 2017, 137 CRLM patients accepting US-guided percutaneous MWA were included. The 2450-MHz microwave ablation system and a cooled-shaft antenna were used. All patients were regularly followed up for at least 6 months...
November 29, 2018: International Journal of Hyperthermia
Yinglin Long, Ronghua Yan, Kai Li, Liping Luo, Qingjing Zeng, Lei Tan, Man Zhang, Rongqin Zheng, Erjiao Xu
PURPOSE: The purpose of this study was to investigate the feasibility, safety and efficacy of intra-procedural contrast-enhanced ultrasound (CEUS) monitoring of the radiofrequency ablation (RFA) of liver cancers adjacent to gallbladder (GB) without GB isolation. MATERIALS AND METHODS: From May 2016 to July 2017, patients with liver cancers adjacent to GB (≤10 mm) who intended to undergo ultrasound-guided RFA without GB isolation in our hospital were prospectively enrolled...
November 29, 2018: International Journal of Hyperthermia
Yan-Hong Yong, Ping Wang, Ru-Min Jia, Ravi Gooneratne, Hwa-Chain Robert Wang, Ming Liao, Xiang-Hong Ju
Hyperthermia in pigs induces suppressor of cytokine signaling (SOCS) 3 and SOCS4 expression in intestinal gut and causes disruption of inflammation cytokine production. These changes may affect the development of inflammatory bowel disease in heat-stressed pigs. However, the mechanisms are not well understood. Accordingly, in this study, we examined the roles of SOCS members in regulation of the nuclear factor (NF)-κB pathway and heat shock protein (HSP) 70-mediated cytokine induction in 293T human embryonic kidney cells and IPEC-J2 porcine small intestinal epithelial cells...
November 28, 2018: International Journal of Hyperthermia
Zhuqing Rao, Wei Ling, Xinzheng Dai, Hui Zhang, Liyong Pu, Jindao Wu, Deming Zhu, Xiao Yang, Zhi Li, Ling Lu, Xuehao Wang, Haoming Zhou, Lianbao Kong
PURPOSE: To evaluate the feasibility of precoagulation with microwave ablation (MWA) for hepatic parenchymal transection during liver partial resection. METHODS: A total of 66 eligible patients were enrolled in this double-blind, randomized, controlled study. Patients were randomized to receive either the traditional clamp-crushing method (Control group) or the MWA precoagulation method (MWA group) for hepatic parenchymal transection during liver partial resection...
November 28, 2018: International Journal of Hyperthermia
Hong Duan, Xiang Fang, Weili Kong, Zeping Yu, Jingqing Qiu
No abstract text is available yet for this article.
November 28, 2018: International Journal of Hyperthermia
Mattia Dimitri, Fabio Staderini, Margherita Brancadoro, Francesco Frosini, Andrea Coratti, Lorenzo Capineri, Andrea Corvi, Fabio Cianchi, Guido Biffi Gentili
PURPOSE: Bleeding from parenchyma transection during a robotic hepatic surgery remains the most critical point affecting postoperative recovery and long-term survival. Various robotic devices with different types of energies have been proposed; however, each of these lack in steerability, efficacy, or accuracy. The aim of this work is to evaluate the feasibility and performance of a new steerable microwave resection device intended for minimizing intraoperative blood loss during laparoscopic and robotic liver resections...
November 28, 2018: International Journal of Hyperthermia
Jieyi Ye, Guangliang Huang, Xiaoer Zhang, Ming Xu, Xiaoyu Zhou, Manxia Lin, Xiaohua Xie, Xiaoyan Xie
PURPOSE: To investigate the feasibility of three-dimensional contrast-enhanced ultrasound (3DCEUS) fusion in evaluating ablative margin (AM) after radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC) and compare with those of computed tomography (CT) fusion. PATIENTS AND METHODS: In total, 55 patients (47 men, 8 women; mean age, 56.0 ± 10.6 years) with 55 HCCs were included. Pre- and post-RFA 3DCEUS images were fused to assess AM immediately after RFA...
November 16, 2018: International Journal of Hyperthermia
Jiang-Ping Cun, Hong-Jie Fan, Wei Zhao, Gen-Fa Yi, Yong-Neng Jiang, Xuan-Cheng Xie
PURPOSE: We investigated the risk factors influencing MR changes associated with sacral injury from ultrasound-guided high-intensity focused ultrasound (USgHIFU) ablation for uterine fibroids. METHODS: We retrospectively analyzed a total of 346 patients with symptomatic uterine fibroids who received USgHIFU ablation. All of the patients underwent contrast-enhanced magnetic resonance imaging (CE-MRI) before and after treatment. Injury to the sacrum was set as the dependent variable, while fibroid features and the treatment parameters were set as independent variables...
November 14, 2018: International Journal of Hyperthermia
Wookyeom Yang, Gwan Hee Han, Ha-Yeon Shin, Eun-Ju Lee, Hanbyoul Cho, Doo Byung Chay, Jae-Hoon Kim
PURPOSE: Modulated electro-hyperthermia (mEHT), known as oncothermia, is an anticancer therapy that induces radiofrequency thermal damage to the cancer tissues. This study aimed to evaluate the potential effectiveness of mEHT as a therapeutic tool in ovarian and cervical cancer. MATERIALS AND METHODS: We used both tumor-bearing mice and ovarian and cervical OVCAR-3, SK-OV-3, HeLa and SNU-17 cancer cell lines to investigate the effects of mEHT in vivo and in vitro, respectively, and determine whether it was enhanced by cotreatment with an autophagy inhibitor...
November 14, 2018: International Journal of Hyperthermia
Ali Dabbagh, Ziba Hedayatnasab, Hamed Karimian, Masoud Sarraf, Chai Hong Yeong, Hamid Reza Madaah Hosseini, Noor Hayaty Abu Kasim, Tin Wui Wong, Noorsaadah Abdul Rahman
PURPOSE: Although magnetite nanoparticles (MNPs) are promising agents for hyperthermia therapy, insufficient drug encapsulation efficacies inhibit their application as nanocarriers in the targeted drug delivery systems. In this study, porous magnetite nanoparticles (PMNPs) were synthesized and coated with a thermosensitive polymeric shell to obtain a synergistic effect of hyperthermia and chemotherapy. MATERIALS AND METHODS: PMNPs were produced using cetyltrimethyl ammonium bromide template and then coated by a polyethylene glycol layer with molecular weight of 1500 Da (PEG1500) and phase transition temperature of 48 ± 2 °C to endow a thermosensitive behavior...
November 14, 2018: International Journal of Hyperthermia
Hong-Jie Fan, Jiang-Ping Cun, Wei Zhao, Jian-Qiang Huang, Gen-Fa Yi, Rui-Hong Yao, Bu-Lang Gao, Xing-Hai Li
OBJECTIVE: To investigate factors affecting effects of ultrasound guided high intensity focused ultrasound (USgHIFU) in the treatment of single uterine fibroids (UFs) with different magnetic resonance imaging (MRI) features. METHODS: A total of 207 patients with single symptomatic UFs who were treated with HIFU were retrospectively analyzed. All UFs were grouped according to MRI features, and factors affecting HIFU ablation were set as independent variables. Non-perfusion volume ratio (NPVR) and energy efficiency factor (EEF) were set as dependent variables to establish multiple linear regression models with a stepwise method...
November 14, 2018: International Journal of Hyperthermia
Zhang Xiao-Ying, Duan Hua, Wang Jin-Juan, Guo Ying-Shu, Cheng Jiu-Mei, Ye Hong, Zang Chun-Yi
OBJECTIVE: To evaluate the long-term clinical effect of high-intensity focussed ultrasound (HIFU) as a non-invasive modality for ablation of abdominal wall endometriosis (AWE) foci. METHODS: All women who were diagnosed with cutaneous endometriosis and underwent HIFU ablation and 4-year follow-up were included. Patient symptoms, imaging performed, HIFU ablation, recurrence, lesion location, size and number were collected and analyzed. RESULTS: A total of 51 women with 57 painful abdominal wall masses with a median volume of 4...
November 14, 2018: International Journal of Hyperthermia
Paola Saccomandi, Alfonso Lapergola, Fabio Longo, Emiliano Schena, Giuseppe Quero
PURPOSE: Pancreatic cancer is a challenging malignancy with low treatment option and poor life expectancy. Thermal ablation techniques were proposed as alternative treatment options, especially in advanced stages and for unfit-for-surgery patients. This systematic review describes the thermal ablative techniques -i.e., Laser (LA), Radiofrequency (RFA), Microwave (MWA) Ablation, High-Intensity Focused Ultrasound (HIFU) and cryoablation- available for pancreatic cancer treatment. Additionally, an analysis of the efficacy, complication rate and overall survival for each technique is conducted...
November 14, 2018: International Journal of Hyperthermia
Roger Olofsson Bagge, Per Carlson, Roya Razzazian, Christoffer Hansson, Anders Hjärpe, Jan Mattsson, Dimitrios Katsarelias
OBJECTIVE: Isolated limb perfusion (ILP) and isolated limb infusion (ILI) are treatment options for patients with locally advanced melanomas and sarcomas of the extremities. ILP potentially have higher response rates, but requires open surgery for vascular access, whereas ILI is minimally invasive and easier to perform. We now present the technical details and outcome of a new approach to ILP by a minimally invasive vascular access (MI-ILP). METHODS: Six patients, five with melanoma in-transit metastases and one with squamous cell carcinoma, were included in a phase I feasibility trial...
November 14, 2018: International Journal of Hyperthermia
Fen Chen, Haiwei Bao, Haiyang Xie, Guo Tian, Tianan Jiang
OBJECTIVE: To establish a model of incomplete ablation in nude mice with hepatocellular carcinoma (HCC) and to evaluate heat shock protein (HSP) expression and autophagy and their correlation. MATERIALS AND METHODS: In the first stage, 12 nude mice with HCC were randomly divided into two groups (n = 6). A sham puncture operation was performed for one group, and palliative laser ablation was performed for the other group. All mice were sacrificed after 18 h, and HSP expression, autophagy, and apoptosis were assessed...
November 14, 2018: International Journal of Hyperthermia
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