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International Journal of Hyperthermia

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https://www.readbyqxmd.com/read/28720001/differential-effects-of-heat-stress-on-fibre-capillarisation-in-tenotomised-soleus-and-plantaris-muscles
#1
Muthita Hirunsai, Ratchakrit Srikuea
PURPOSE: Capillary regression is commonly observed in response to disuse muscle atrophy. Heat stress is known to alleviate muscle atrophy, while effect of heat exposure on capillary adaptation following disuse atrophy is not defined. Here, we examined the effect of heat treatment on capillarisation and the associated signalling in slow-oxidative soleus and fast-glycolytic plantaris muscles following Achilles tendon ablation (tenotomy). MATERIALS AND METHODS: Male Wistar rats were assigned into control (CON), control with heat stress (CON + HEAT), tenotomy (TEN) and tenotomy with heat stress (TEN + HEAT) groups...
July 18, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28715967/hyperthermia-enhanced-targeted-drug-delivery-using-magnetic-resonance-guided-focussed-ultrasound-a-pre-clinical-study-in-a-genetic-model-of-pancreatic-cancer
#2
Navid Farr, Yak-Nam Wang, Samantha D'Andrea, Frank Starr, Ari Partanen, Kayla M Gravelle, Jeannine S McCune, Linda J Risler, Stella G Whang, Amy Chang, Sunil R Hingorani, Donghoon Lee, Joo Ha Hwang
PURPOSE: The lack of effective treatment options for pancreatic cancer has led to a 5-year survival rate of just 8%. Here, we evaluate the ability to enhance targeted drug delivery using mild hyperthermia in combination with the systemic administration of a low-temperature sensitive liposomal formulation of doxorubicin (LTSL-Dox) using a relevant model for pancreas cancer. MATERIALS AND METHODS: Experiments were performed in a genetically engineered mouse model of pancreatic cancer (KPC mice: LSL-Kras(G12D/+); LSL-Trp53(R172H/+); Pdx-1-Cre)...
July 17, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28705099/heat-induced-brca2-degradation-in-human-tumors-provides-rationale-for-hyperthermia-parp-inhibitor-combination-therapies
#3
Nathalie van den Tempel, Hanny Odijk, Netteke van Holthe, Kishan Naipal, Anja Raams, Berina Eppink, Dik van Gent, Jose Hardillo, Gerda Verduijn, Jan Drooger, Gerard van Rhoon, Dineke Smedts, Helena van Doorn, Joost Boormans, Agnes Jager, Martine Franckena, Roland Kanaar
PURPOSE: Hyperthermia (40-44°C) effectively sensitizes tumors to radiotherapy by locally altering tumor biology. One of the effects of heat at the cellular level is inhibition of DNA repair by homologous recombination via degradation of the BRCA2-protein. This suggests that hyperthermia can expand the group of patients that benefit from PARP-inhibitors, a drug exploiting homologous recombination deficiency. Here, we explore whether the molecular mechanisms that cause heat-mediated degradation of BRCA2 are conserved in cell lines from various origins and, most importantly, whether, BRCA2 protein levels can be attenuated by heat in freshly biopted human tumors...
July 13, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28705098/prevention-of-systemic-toxicity-in-hyperthermic-isolated-lung-perfusion-using-radioisotopic-leakage-monitoring
#4
Francesco Fiz, Giuseppe Villa, Enrico Ferrari, Elena Pomposelli, Silvia Morbelli, Antonella Alloisio, Daniela Pende, Raffaella Meazza, Cristina Gereloni, Cecilia Marini, Giovanni Battista Ratto, Gianmario Sambuceti
RATIONALE: Hyperthermic isolated lung Perfusion (ILuP) is used to deliver high-dose chemotherapy to pulmonary metastases while sparing systemic toxicity. Accurate leakage monitoring is however necessary. This study aimed to verify the accuracy of radionuclide leakage monitoring in patients undergoing ILuP, by comparing this method with serial blood sampling. METHODS: A total of 15 consecutive ILuP procedures were performed on eleven patients affected by lung metastases from soft tissue sarcoma...
July 13, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28693357/effect-of-acute-ambient-temperature-exposure-on-cardio-pulmonary-and-respiratory-kinetics-in-men
#5
U Drescher, J Koschate, U Hoffmann, S Schneider, A Werner
PURPOSE: The goal of the study was to compare the kinetics responses of heart rate (HR) and pulmonary (V'O2pulm) and muscular (V'O2musc) oxygen uptake during dynamic leg exercise across different acute ambient temperature conditions in a climatic chamber. METHODS: Thirteen physically healthy, active male volunteers performed pseudo-random binary sequence (PRBS) work rate (WR) changes between 30 W and 80 W at 15°C, 25°C and 35°C, respectively. HR was measured beat-to-beat by echocardiogram and V'O2pulm by breath-by-breath gas exchange, and V'O2musc estimations were assessed by applying a circulatory model and cross-correlation functions based on the approach of Hoffmann et al...
July 10, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28689443/does-having-a-gastrectomy-delay-time-to-feeding-and-prolong-hospital-stay-in-patients-undergoing-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy
#6
Nicholas B Shannon, Grace Hwei Ching Tan, Claramae Shulyn Chia, Khee Chee Soo, Melissa Ching Teo
AIM: Cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) are routinely used to treat selected patients with peritoneal carcinomatosis, but can be associated with prolonged hospital stay, significant morbidity and mortality. Our objective was to assess whether patients undergoing gastrectomy as part of CRS/HIPEC were at increased risk of delayed feeding time and prolonged hospital stay. METHOD: 214 consecutive patients with peritoneal carcinomatosis treated with CRS/HIPEC between 2001 and 2016 were stratified by whether CRS included gastrectomy (n = 19, 9%) and compared...
July 9, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28683587/ca-125-an-inaccurate-surveillance-tool-immediately-after-cytoreductive-surgery-and-hyperthermic-intraoperative-chemotherapy-crs-hipec
#7
Nicholas Brian Shannon, Grace Hwei Ching Tan, Claramae Shulyn Chia, Khee Chee Soo, Melissa Ching Ching Teo
OBJECTIVE: This study seeks to evaluate pre and post-operative CA-125 in patients undergoing complete cytoreduction surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC), and understand the time frame before values normalise allowing use as a surveillance tool to resume. METHODS: A retrospective review was carried out of 94 patients undergoing CRS-HIPEC to compare pre-operative CA-125 values, measured within one week prior to surgery to post-operative readings within the first 30 d...
July 6, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28679349/relationships-between-thermal-dose-parameters-and-the-efficacy-of-definitive-chemoradiotherapy-plus-regional-hyperthermia-in-the-treatment-of-locally-advanced-cervical-cancer-data-from-a-multicenter-randomized-clinical-trial
#8
Takayuki Ohguri, Yoko Harima, Hajime Imada, Hideyuki Sakurai, Tatsuya Ohno, Yoshiyuki Hiraki, Koh Tuji, Masahiro Tanaka, Hiromi Terashima
PURPOSE: To evaluate the contribution of the thermal dose parameters during regional hyperthermia (HT) treatment to the clinical outcomes in patients with cervical carcinoma (CC) who received chemoradiotherapy (CRT) plus HT. MATERIALS AND METHODS: Data from a multicenter randomized clinical trial of concurrent CRT+HT vs. CRT alone were used to evaluate the efficacy and safety of this combination therapy in the CC patients. The intrarectal temperatures of patients undergoing HT were recorded...
July 5, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28679331/predictive-value-of-peritoneal-cancer-index-for-survival-in-patients-with-mucinous-peritoneal-malignancies-treated-with-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-a-single-center-experience
#9
Andreas Brandl, Sascha Weiss, Moritz von Winterfeld, Alexander Krannich, Matthilde Feist, Johann Pratschke, Wieland Raue, Beate Rau
OBJECTIVES: This study investigated the correlation between the peritoneal carcinomatosis index (PCI) and patient outcome depending on the tumor type. BACKGROUND: Peritoneal surface malignancy (PSM) treatment depends on tumor type. Mucinous PSM (m-PSM) is associated with a better prognosis than non-mucinous PSM (nm-PSM). The PCI´s predictive ability has not yet been evaluated. METHODS: We analyzed 123 patients with PSM treated with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) between 2008 and 2015...
July 5, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28678571/therapeutical-effect-of-intrapleural-perfusion-with-hyperthermic-chemotherapy-on-malignant-pleural-effusion-under-video-assisted-thoracoscopic-surgery
#10
Xing Feng, Lucheng Zhu, Xiaoling Xiong, Hong Jiang, Zhibing Wu, Wen Meng, Yasi Xu, Shirong Zhang, Shenglin Ma
BACKGROUND: Patients with malignant pleural effusions (MPEs) have limited life expectancy. This study aims to investigate the feasibility of intrapleural perfusion with hyperthermic chemotherapy (IPHC) under video-assisted thoracoscopic surgery on MPE patients. METHODS: MPE patients were enrolled in the study and treated with IPHC. The treatment response was classified as complete response (CR, no re-accumulation of pleural fluid for 4 weeks), partial response (PR, re-accumulation above the post-IPHC level but below the pre-IPHC level for four weeks), no response (NR; re-accumulation or above the pre-IPHC level)...
July 5, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28641499/a-comprehensive-model-for-heat-induced-radio-sensitisation
#11
Sarah Catharina Brüningk, Jannat Ijaz, Ian Rivens, Simeon Nill, Gail Ter Haar, Uwe Oelfke
Combined radiotherapy (RT) and hyperthermia (HT) treatments may improve treatment outcome by heat induced radio-sensitisation. We propose an empirical cell survival model (AlphaR model) to describe this multimodality therapy. The model is motivated by the observation that heat induced radio-sensitisation may be explained by a reduction in the DNA damage repair capacity of heated cells. We assume that this repair is only possible up to a threshold level above which survival will decrease exponentially with dose...
July 5, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28659004/role-of-hif-1%C3%AE-in-response-of-tumors-to-a-combination-of-hyperthermia-and-radiation-in-vivo
#12
Wonwoo Kim, Mi-Sook Kim, Hee-Jong Kim, Eunjin Lee, Jae-Hoon Jeong, Inhwan Park, Youn Kyoung Jeong, Won Il Jang
PURPOSE: Mild temperature hyperthermia (MTH) increases blood flow and oxygenation in tumours. On the other hand, high-dose-per-fraction irradiation damages blood vessels, decreases blood flow and increases hypoxia in tumours. The radiation-induced hypoxia in tumours activates hypoxia-inducible factor-1α (HIF-1α) and its target genes, such as vascular endothelial growth factor (VEGF), promoting revascularization and recurrence. In the present study, we examined the hypothesis that MTH inhibits radiation-induced upregulation of HIF-1α and its target genes by increasing tumour oxygenation...
June 28, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28641464/ultrasound-guided-hydrodissection-for-assisting-percutaneous-microwave-ablation-of-renal-cell-carcinomas-adjacent-to-intestinal-tracts-a-preliminary-clinical-study
#13
Zhigang Cheng, Xiaoling Yu, Zhiyu Han, Fangyi Liu, Jie Yu, Ping Liang
PURPOSE: To evaluate the safety and efficacy of the clinical application of hydrodissection under ultrasound (US) guidance for assisting percutaneous microwave ablation (MWA) for the treatment of renal cell carcinomas (RCCs) adjacent to the intestinal tract. MATERIALS AND METHODS: From April 2014 to December 2016, clinical data from 24 patients with 25 RCCs were retrospectively analysed. Percutaneous MWA under the assistance of US-guided hydrodissection were performed to treat RCCs with a mean maximal diameter of 3...
June 22, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28633613/thermal-effects-on-cognition-a-new-quantitative-synthesis
#14
José Ignacio López-Sánchez, P A Hancock
There is little doubt that increases in thermal load beyond the thermo-neutral state prove progressively stressful to all living organisms. Increasing temperatures across the globe represent in some locales, and especially for outdoors workers, a significant source of such chronic load increase. However, increases in thermal load affect cognition as well as physical work activities. Such human cognition has perennially been viewed as the primary conduit through which to solve many of the iatrogenic challenges we now face...
June 20, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28633580/platinum-agents-and-mitomycin-c-specific-complications-in-cytoreductive-surgery-crs-and-hyperthermic-intraperitoneal-chemotherapy-hipec
#15
Grace Hwei Ching Tan, Nicholas B Shannon, Claramae Shulyn Chia, Khee Chee Soo, Melissa Ching Ching Teo
INTRODUCTION: Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) have been found to prolong survival in patients with peritoneal disease but is associated with significant morbidity. We evaluate the perioperative complications and the association with the chemotherapy agent used for HIPEC. METHODS: Retrospective analysis of a prospectively collected database of CRS-HIPEC cases between April 2001 and February 2016 was performed. Patients were stratified by the chemotherapy used, and perioperative complications were compared...
June 20, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28554240/numerical-analysis-of-thermal-impact-of-intramyocardial-capillary-blood-flow-during-radiofrequency-cardiac-ablation
#16
Juan J Pérez, Ana González-Suárez, Enrique Berjano
PURPOSE: The thermal effect of the intramyocardial blood perfusion on the size of lesions created by radiofrequency cardiac ablation (RFCA) has not been adequately studied to date. Our objective was to assess the impact of including this phenomenon in RFCA computer modelling in terms of the thermal lesion depth created. METHODS: A computer model was built and computer simulations were conducted to assess the effect of including the blood perfusion term in the bioheat equation...
June 18, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28545303/a-thermoelastic-deformation-model-of-tissue-contraction-during-thermal-ablation
#17
Chang Sub Park, Cong Liu, Sheldon K Hall, Stephen J Payne
PURPOSE: Thermal ablation is an energy-based ablation technique widely used during minimally invasive cancer treatment. Simulations are used to predict the dead tissue post therapy. However, one difficulty with the simulations is accurately predicting the ablation zone in post-procedural images due to the contraction of tissue as a result of exposure to elevated temperatures. MATERIALS AND METHODS: A mathematical model of the thermoelastic deformation for an elastic isotropic material was coupled with a three state thermal denaturation model to determine the contraction of tissue during thermal ablation...
June 14, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28610551/passive-cooling-of-cutaneous-and-subcutaneous-tissues-using-phase-changing-materials-feasibility-study-using-a-numerical-model
#18
Ricardo Romero-Méndez, Francisco G Pérez-Gutiérrez, Joseph J Musacchia, Walfre Franco
In many dermatological applications, lowering the temperature of skin and maintaining specific temperatures for extended periods of time are fundamental requirements for treatment; for example, in targeting adipose tissue and managing cutaneous pain. In this work we investigate the feasibility of using phase changing materials (PCMs) as an alternative passive, open-loop, heat extraction method for cooling cutaneous and subcutaneous tissues. We used a finite difference parametric approach to model the spatial and temporal progression of the heat transferred from the skin to a PCM in contact with the skin surface...
June 13, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28610455/non-fourier-thermal-transport-induced-structural-hierarchy-and-damage-to-collagen-ultrastructure-subjected-to-laser-irradiation
#19
Nilamani Sahoo, Arunn Narasimhan, Purbarun Dhar, Sarit Kumar Das
Comprehending the mechanism of thermal transport through biological tissues is an important factor for optimal ablation of cancerous tissues and minimising collateral tissue damage. The present study reports detailed mapping of the rise in internal temperature within the tissue mimics due to NIR (1064 nm) laser irradiation, both for bare mimics and with gold nanostructures infused. Gold nanostructures such as mesoflowers and nano spheres have been synthesized and used as photothermal converters to enhance the temperature rise, resulting in achieving the desired degradation of malignant tissue in targeted region...
June 13, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28605996/in-vitro-exposure-of-bull-sperm-cells-to-dmsa-coated-maghemite-nanoparticles-does-not-affect-cell-functionality-or-structure
#20
Denise Ferreira Caldeira, Fernanda Paulini, Renata Carvalho Silva, Ricardo Bentes de Azevedo, Carolina Madeira Lucci
Magnetic nanoparticles can be used in different areas of biology. It is therefore important to know the effects of such nanomaterials on germline cells as they may traverse the blood-testis barrier. This work aimed to evaluate the response of bull sperm after exposure to a magnetic fluid containing DMSA-coated maghemite nanoparticles (MNP-DMSA) in order to determine nanotoxicity. Bull sperm was incubated with MNP-DMSA at final concentrations of 0.06, 0.03 or 0.015 mg Fe/mL. Sperm kinetics, plasma membrane integrity and acrosome reaction were evaluated over a four-hour incubation period...
June 12, 2017: International Journal of Hyperthermia
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