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International Journal of Hyperthermia

Jinshun Xu, Yang Cao, Chunyan Xu, Xueqing Cheng, Yufeng You, Yuanzhi Yao, Jianxin Liu, Zhigang Wang, Pan Li, Min Lu
OBJECTIVES: To determine whether combining microbubbles (MBs) with diagnostic ultrasound (US) at a high mechanical index (MI) could enhance the microwave (MW) ablation of tumours. MATERIALS AND METHODS: Five therapeutic MW adjuvant protocols were studied: MW, MW + US, MW + US + MB, MW + US + NS (saline), and MW + MB. In 30 normal rabbit livers, the synergistic effects were evaluated via temperature, necrosis volume and histology. In 90 VX2 rabbit hepatic tumours, residual cells in the peripheral ablated tumours were examined via immunohistochemical assay and tumour growth...
October 20, 2016: International Journal of Hyperthermia
C M van Leeuwen, J Crezee, A L Oei, N A P Franken, L J A Stalpers, A Bel, H P Kok
PURPOSE: Currently, clinical decisions regarding thermoradiotherapy treatments are based on clinical experience. Quantification of the radiosensitising effect of hyperthermia allows comparison of different treatment strategies, and can support clinical decision-making regarding the optimal treatment. The software presented here enables biological evaluation of thermoradiotherapy plans through calculation of equivalent 3D dose distributions. METHODS: Our in-house developed software (X-Term) uses an extended version of the linear-quadratic model to calculate equivalent radiation dose, i...
October 17, 2016: International Journal of Hyperthermia
Xin Li, Jie Yu, Ping Liang, Xiaoling Yu, Chengzhi Gang, Hanzhi Yu, Hui Huang, Shaobo Duan, Jiasheng Zheng
Purpose To analyze the clinical outcomes of combination therapy of three-dimensional (3D) visualization operative treatment planning system and US-guided percutaneous microwave ablation (PMWA) in larger renal cell carcinomas (RCCs) (D≥4cm). Materials and Methods The results from 20 patients with 20 larger RCCs treated with 3D visualization operative treatment planning system and US-guided PMWA were reviewed retrospectively. The patients were followed up by contrast-enhanced images at 1, 3, and 6 months and every 6 months thereafter...
October 11, 2016: International Journal of Hyperthermia
Yun Xu, Qiang Shen, Neng Wang, Pei Liu, Panpan Wu, Zhenwei Peng, Guojun Qian
OBJECTIVE: This study aims to evaluate the local efficacy and long-term outcomes of microwave ablation (MWA) for treating large unresectable hepatocellular carcinomas (HCCs). METHODS: A total of 82 patients with 5-6 cm unresectable HCCs, who underwent a single MWA procedure during the period of January 2007 to July 2011, were retrospectively enrolled into this study. Percentages of technical success and complications of MWA and HCC local recurrence (LR) after MWA were determined...
October 9, 2016: International Journal of Hyperthermia
Zheng Li, Kai Zhang, Shu-Mei Lin, Deng-Hai Mi, Nong Cao, Zhi-Zhen Wen, Zhong-Xin Li
BACKGROUND: Radiofrequency ablation (RFA) and percutaneous ethanol injection (PEI) are important treatments for patients with hepatocellular carcinoma (HCC) who are not eligible for resection and liver transplantation. Therefore, it is important to establish comparisons between RFA, PEI and the two therapies in combination. AIMS: To evaluate the clinical efficacy and safety of combined RFA-PEI versus monotherapy with either RFA or PEI for HCC to provide references for clinical practice and further research...
October 5, 2016: International Journal of Hyperthermia
Rita Quesada, Ignasi Poves, Enrique Berjano, Carles Vilaplana, Anna Andaluz, Xavier Moll, Dimitri Dorcaratto, Luis Grande, Fernando Burdio
PURPOSE: To evaluate the impact of using monopolar thermal coagulation based on radiofrequency (RF) currents on intraoperative blood loss during liver resection. MATERIALS AND METHODS: A prospective randomised controlled trial was planned. Patients undergoing hepatectomy were randomised into two groups. In the control group (n = 10), hemostasis was obtained with a combination of stitches, vessel-sealing bipolar RF systems, sutures or clips. In the monopolar radiofrequency coagulation (MRFC) group (n = 18), hemostasis was mainly obtained using an internally cooled monopolar RF electrode...
October 5, 2016: International Journal of Hyperthermia
Samira Eynali, Samideh Khoei, Sepideh Khoei, Elaheh Esmaelbeygi
The purpose of this study was to evaluate the combined effects of heat and poly lactic-co-glycolic acid (PLGA) nanoparticles, as 5-fluorouracil carriers with/without iron oxide core, on the viability and proliferation capacity of human colon cancer cell line HT-29 in the spheroid model. HT-29 spheroid cells were treated with different concentrations of 5-FU or 5-FU loaded into both nanoparticles for 74 h. Hyperthermia was then performed at 43°C for 60 min. Finally, the effects of the mentioned treatments on cell viability and proliferation capacity were evaluated using the trypan blue dye exclusion test and colony formation assay, respectively...
October 4, 2016: International Journal of Hyperthermia
Giovanni Mauri, Luca Cova, Cristian Giuseppe Monaco, Luca Maria Sconfienza, Sabrina Corbetta, Stefano Benedini, Federico Ambrogi, Valentina Milani, Alberto Baroli, Tiziana Ierace, Luigi Solbiati
PURPOSE: To evaluate the reduction over time of benign thyroid nodules treated using percutaneous laser ablation (PLA) and radiofrequency ablation (RFA) by the same equipe. MATERIALS AND METHODS: Ninety patients (age 55.6±14.1 years) underwent ablation for benign thyroid nodule causing compression/aesthetic dissatisfaction from 2011. Fifty-nine (age 55.8±14.1 years) underwent RFA and 31 (age 55.2±14.2 years) PLA, ultrasound guided. Technical success, complications, duration of ablation and treatment, energy deployed, volumetric percentage reduction at 1, 6, and 12 months were derived...
October 4, 2016: International Journal of Hyperthermia
Jie Yu, Ping Liang
Tumor ablation is defined as the direct application of chemical or thermal therapy to eradicate or substantially destroy a tumor. Currently, minimally invasive ablation techniques are available for the local destruction of focal tumors in multiple organ sites. Microwave ablation is premised on the biological response of solid tumors to tissue hyperthermia, and it is a relatively low-risk procedure. Due to several advantages of microwave ablation, including higher thermal efficiency, higher capability for coagulating blood vessels, faster ablation time, and the simultaneous application of multiple antennae, microwave ablation could be a promising minimally invasive ablation technique for the treatment of solid tumors...
October 4, 2016: International Journal of Hyperthermia
Legha Ansari, Bizhan Malaekeh-Nikouei
This paper summarizes nearly all magnetic silica nanocomposites that have been synthesized for biomedical applications and evaluated under alternating magnetic field (AMF) from the point of view of heat generation. The use of these nanocomposites as a drug delivery system for remote control of drug release via applying AMF is described. Different parameters that affect the magnetic properties and therefore affect the amount of generated heat and the fact that sometimes these parameters are in conflict with each other are discussed...
October 2, 2016: International Journal of Hyperthermia
Mirjam C L Peek, Muneer Ahmed, Alessandro Napoli, Sasha Usiskin, Rose Baker, Michael Douek
PURPOSE: Breast-conserving surgery is effective for breast cancer treatment but is associated with morbidity in particular high re-excision rates. We performed a systematic review and meta-analysis to assess the current evidence for clinical outcomes with minimally invasive ablative techniques in the non-surgical treatment of breast cancer. METHODS: A systematic search of the literature was performed using PubMed and Medline library databases to identify all studies published between 1994 and May 2016...
October 2, 2016: International Journal of Hyperthermia
Cong Liu, Chang Sub Park, Sheldon K Hall, Stephen J Payne
PURPOSE: A hyperdense rim is commonly observed at the periphery of ablation zones during post-ablation imaging (e.g. ultrasound) in tumours. A mathematical model has been developed here to investigate the occurrence of this enhanced rim, caused by the ablated cells, giving an indication of the location of the final ablation region. MATERIALS AND METHODS: The enhanced rim has been assumed here to be due to a tissue-level oedematic response of viable cells, which necessitated coupling multiple modelling elements in a spatially distributed system: thermal cell death, tissue-state dependent ion concentration dynamics, ion transport in the extracellular space, and osmotic cell volume regulation...
September 28, 2016: International Journal of Hyperthermia
Markus Notter, Helmut Piazena, Peter Vaupel
PURPOSE: Evaluation of the efficacy and toxicity of a new setup of thermographically controlled water-filtered infra-red-A (wIRA) superficial hyperthermia (HT) combined with hypofractionated re-irradiation (re-RT) to treat large-sized breast cancer recurrences. METHODS: Records of 73 heavily pre-irradiated patients with 103 treatment regions, treated from September 2009 to July 2015 were retrospectively analysed. Sixty-four patients with macroscopic disease were treated with 94 regions including 46 patients with lymphangiosis carcinomatosa...
September 28, 2016: International Journal of Hyperthermia
David Padilla-Valverde, Susana Sanchez-Garcia, Esther García-Santos, Carlos Marcote-Ibañez, Mercedes Molina-Robles, Jesús Martín-Fernández, Pedro Villarejo-Campos
PURPOSE: To determine the effectiveness of thermography to control the distribution of abdominal temperature in the development of a closed chemohyperthermia model Materials and Methods: For thermographic analysis, we divided the abdominopelvic cavity into nine regions according to a modification of carcinomatosis peritoneal index. A difference of 2.5º C between and within the quadrants, and thermographic colors, were used as asymmetric criteria. Preclinical study: Rats Model: Six athymic nude rats, male, rnu/rnu...
September 16, 2016: International Journal of Hyperthermia
Katja Zimmermann, Martin Hossann, Johannes Hirschberger, Karin Troedson, Michael Peller, Moritz Schneider, Andreas Brühschwein, Andrea Meyer-Lindenberg, Gerhard Wess, Melanie Wergin, René Dörfelt, Thomas Knösel, Markus Schwaiger, Christine Baumgartner, Johanna Brandl, Sabine Schwamberger, Lars H Lindner
PURPOSE: Doxorubicin (DOX)-loaded phosphatidyldiglycerol-based thermosensitive liposomes (DPPG2-TSL-DOX) combined with local hyperthermia (HT) were evaluated in cats with locally advanced spontaneous fibrosarcomas (soft tissue sarcoma, STS). The study was designed to evaluate the safety and pharmacokinetic profile of the drug. Results from four dose-levels are reported. METHODS: Eleven client-owned cats with advanced STS were enrolled. Five cats received escalating doses of 0...
September 4, 2016: International Journal of Hyperthermia
Ji-Hoon Kim, Jung Hwan Baek, Jin Yong Sung, Hye Sook Min, Kyung Won Kim, J Hun Hah, Do Joon Park, Kwang Hyun Kim, Bo Youn Cho, Dong Gyu Na
Purpose To retrospectively evaluate the outcomes of radiofrequency ablation (RFA) of low-risk small PTCs in patients who were ineligible for surgery. Materials and Methods Between 2005 and 2009, 6 PTCs (mean diameter, 0.92 cm, range, 0.6-1.3 cm) in 6 patients were treated with RFA by 3 radiologists in 2 hospitals. The inclusion criteria for this study were 1) pathologically confirmed PTC without cytologic agressivness, 2) single PTC without extrathyroidal extension, 3) no metastatic tumors, and 4) ineligibility for surgery...
September 2, 2016: International Journal of Hyperthermia
Kun Yan, Wei Yang, Min-Hua Chen, Zhong-Yi Zhang, Jung-Chieh Lee, Hai-Xing Liao, Wei Wu, S Nahum Goldberg
PURPOSE: To determine the efficacy and safety of percutaneous hepatic wedge ablation in treating hepatic malignancies of the inferior margin. MATERIALS AND METHODS: 77 patients with hepatic malignancies at the inferior margin underwent percutaneous radiofrequency ablation (RFA). 32 patients underwent hepatic wedge ablation and 45 patients underwent conventional tumor ablation. Comparative analysis of the two groups was performed including gender, age, tumor size, number of ablation cycles, ablation duration, and injected hydrodissection volume...
September 2, 2016: International Journal of Hyperthermia
R Mooney, E Schena, P Saccomandi, A Zhumkhawala, K S Aboody, J M Berlin
PURPOSE: The aim of the present study was the in vivo assessment of the effects of gold nanorod (AuNR)-mediated laser ablation (LA) of flank xenograft tumors. We investigated: the differences between intra-tumoral (TIT) and surface tumoral temperature (TS); the influence of AuNRs concentration and laser power (P) on both these temperatures and on tumor regression. Lastly, experimental data were used to validate a theoretical model developed to predict the effects of AuNR-mediated LA. MATERIALS AND METHODS: Thirty-two nude mice were treated using near-infrared light at two P, three days after injecting increasing AuNR doses...
August 31, 2016: International Journal of Hyperthermia
Sundeep Singh, Ramjee Repaka
PURPOSE: This study aims to analyse the efficacy of temperature-controlled radiofrequency ablation (RFA) in different tissues. MATERIALS AND METHODS: A three-dimensional, 12 cm cubical model representing the healthy tissue has been studied in which spherical tumour of 2.5 cm has been embedded. Different body sites considered in the study are liver, kidney, lung and breast. The thermo-electric analysis has been performed to estimate the temperature distribution and ablation volume...
August 30, 2016: International Journal of Hyperthermia
Jianfeng Wang, Yaoping Shi, Zhibin Bai, Yonggang Li, Longhua Qiu, Guy Johnson, Feng Zhang, Xiaoming Yang
PURPOSE: To determine the feasibility of using radiofrequency hyperthermia (RFH) to enhance the therapeutic effect of herpes simplex virus thymidine kinase/ganciclovir (HSV-TK/GCV) for the treatment of hepatocellular carcinoma (HCC). MATERIALS AND METHODS: Human HCC cells (HepG2) were first transfected with lentivirus/luciferase. For both in-vitro confirmation and in-vivo validation, luciferase-labeled HCC cells and HCC tumor xenografts on mice received different treatments: (i) combination therapy of intratumoral HSV-TK/GCV-mediated gene therapy plus MR imaging-heating-guidewire (MRIHG)-mediated RFH; (ii) gene therapy only; (iii) RFH only; and (iv) phosphate-buffered saline (PBS) as control...
August 28, 2016: International Journal of Hyperthermia
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