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International Journal of Hyperthermia

Eunbi Ye, Jinhwan Baik, Seunghyun Lee, Seon Young Ryu, Sunchoel Yang, Eue-Keun Choi, Won Hoon Song, Hyeong Dong Yuk, Chang Wook Jeong, Sung-Min Park
PURPOSE: In this study, we propose a novel laparoscopy-based renal denervation (RDN) system for treating patients with resistant hypertension. In this feasibility study, we investigated whether our proposed surgical instrument can ablate renal nerves from outside of the renal artery safely and effectively and can overcome the depth-related limitations of the previous catheter-based system with less damage to the arterial walls. METHOD: We designed a looped bipolar electrosurgical instrument to be used with laparoscopy-based RDN system...
May 18, 2018: International Journal of Hyperthermia
Sergio Sartori, Giovanni Mauri, Paola Tombesi, Francesca Di Vece, Lara Bianchi, Claudio Maurizio Pacella
PURPOSE: The aim of this retrospective study was to assess the safety and effectiveness of laser ablation (LA) in patients with small renal cell carcinomas (RCC) and increased risk of bleeding. MATERIAL AND METHODS: From 2013 to 2017, nine patients (six males, three females, aged 68.5 ± 12.2 years) at high risk of bleeding underwent ultrasonography-guided LA for an RCC. Patients were considered at increased risk of bleeding because of impairment of coagulation parameters, concomitant antiplatelet therapy, or at-risk location of the tumor (one, five, and three patients, respectively)...
May 11, 2018: International Journal of Hyperthermia
C M van Leeuwen, J Crezee, A L Oei, N A P Franken, L J A Stalpers, A Bel, H P Kok
PURPOSE: Thermoradiotherapy is an effective treatment for locally advanced cervical cancer. However, the optimal time interval between radiotherapy and hyperthermia, resulting in the highest therapeutic gain, remains unclear. This study aims to evaluate the effect of time interval on the therapeutic gain using biological treatment planning. METHODS: Radiotherapy and hyperthermia treatment plans were created for 15 cervical cancer patients. Biological modeling was used to calculate the equivalent radiation dose, that is, the radiation dose that results in the same biological effect as the thermoradiotherapy treatment, for different time intervals ranging from 0-4 h...
May 11, 2018: International Journal of Hyperthermia
G M Verduijn, E M de Wee, Z Rijnen, P Togni, J A U Hardillo, I Ten Hove, M Franckena, G C van Rhoon, M M Paulides
PURPOSE: Radiotherapy (RT) treatment of locally-advanced and recurrent head and neck carcinoma (HNC) results in disappointing outcomes. Combination of RT with cisplatin or cetuximab improves survival but the increased toxicity and patient's comorbidity warrant the need for a less-toxic radiosensitizer. Stimulated by several randomized studies demonstrating the radio-sensitizing effect of hyperthermia, we developed the HYPERcollar. Here, we report early experience and toxicity in patients with advanced HNC...
May 11, 2018: International Journal of Hyperthermia
Peter Vaupel, Helmut Piazena, Werner Müller, Markus Notter
Thermography-controlled, water-filtered infrared-A (wIRA) is a novel, effective and approved heating technique listed in the ESHO quality assurance guidelines for superficial hyperthermia clinical trials (2017). In order to assess the special features and the potential of wIRA-hyperthermia (wIRA-HT), detailed and updated information about its physical and photobiological background is presented. wIRA allows for (a) application of high irradiances without skin pain and acute grade 2-4 skin toxicities, (b) prolonged, therapeutically relevant exposure times using high irradiances (150-200 mW/cm2 ) and (c) faster and deeper heat extension within tissues...
May 10, 2018: International Journal of Hyperthermia
Yingbing Wang, Michael Lanuti, Adam Bernheim, Jo-Anne O Shepard, Amita Sharma
PURPOSE: The goal of this study was to define patterns for tumor recurrence on PET following RFA, compare time to imaging recurrence by PET versus CT, evaluate whether pre-treatment tumor uptake predicts recurrence and propose an optimal post-RFA surveillance strategy. MATERIALS AND METHODS: A retrospective cohort study was performed of biopsy confirmed primary stage I lung cancers treated with RFA. FDG PET and near contemporaneous diagnostic CT imaging pre-ablation, within 30 days post-ablation, and beyond 6 months were independently and retrospectively evaluated for features supportive of recurrence...
May 3, 2018: International Journal of Hyperthermia
Hao Hu, Guo Feng Chen, Wei Yuan, Jian Hua Wang, Bo Zhai
OBJECTIVE: To evaluate the safety and long-term outcomes of microwave ablation (MWA) combined with transarterial chemoembolization (TACE) in a single stage for the treatment of hepatocellular carcinoma (HCC) with a maximum diameter of 5.0-10.0 cm. METHODS: From January 2013 to December 2016, 84 consecutive HCC patients with cirrhosis from two medical centers who underwent MWA-TACE as a first-line treatment for up to three HCCs with maximum diameters of 5.0-10...
May 2, 2018: International Journal of Hyperthermia
Akke Bakker, Rebecca Holman, Dario B Rodrigues, Hana Dobšíček Trefná, Paul R Stauffer, Geertjan van Tienhoven, Coen R N Rasch, Hans Crezee
PURPOSE: Tumor response and treatment toxicity are related to minimum and maximum tissue temperatures during hyperthermia, respectively. Using a large set of clinical data, we analyzed the number of sensors required to adequately monitor skin temperature during superficial hyperthermia treatment of breast cancer patients. METHODS: Hyperthermia treatments monitored with >60 stationary temperature sensors were selected from a database of patients with recurrent breast cancer treated with re-irradiation (23 × 2 Gy) and hyperthermia using single 434 MHz applicators (effective field size 351-396 cm2 )...
April 27, 2018: International Journal of Hyperthermia
M Enblad, L Ghanipour, P H Cashin
BACKGROUND: Selecting colorectal patients for HIPEC-surgery needs improvement. The study aim was to improve the colorectal peritoneal score (COREP) and to compare it with three other scores: peritoneal-surface disease-severity score (PSDS), colorectal-peritoneal metastases prognostic-surgical-score (COMPASS), and the CEA/PCI ratio. METHOD: Twelve preoperative factors were chosen to evaluate for COREP score modification. Criteria from logistical analyses were set to qualify for the modified COREP score (mCOREP)...
April 25, 2018: International Journal of Hyperthermia
H P Kok, F Navarro, L Strigari, M Cavagnaro, J Crezee
BACKGROUND: Locoregional hyperthermia is applied to deep-seated tumours in the pelvic region. Two very different heating techniques are often applied: capacitive and radiative heating. In this paper, numerical simulations are applied to compare the performance of both techniques in heating of deep-seated tumours. METHODS: Phantom simulations were performed for small (30 × 20 × 50 cm3 ) and large (45 × 30 × 50 cm3 ), homogeneous fatless and inhomogeneous fat-muscle, tissue-equivalent phantoms with a central or eccentric target region...
April 18, 2018: International Journal of Hyperthermia
Hiroshi Kodama, Eisuke Ueshima, Song Gao, Sebastien Monette, Lee-Ronn Paluch, Kreg Howk, Joseph P Erinjeri, Stephen B Solomon, Govindarajan Srimathveeravalli
PURPOSE: The purpose of this study is to assess the impact of duration of energy delivery on adverse events (AEs) and heat sink effects during high power microwave ablation (MWA) of normal swine lung. MATERIALS AND METHODS: High power (100 W) MWA was performed with short (2 min, 18 ablations) or long (10 min, nine ablations) duration of energy delivery in unilateral lung of swine (n = 10). CT imaging was done prior to sacrifice at 2 or 28 d post-treatment, with additional imaging at 7 and 14 d for the latter cohort...
April 18, 2018: International Journal of Hyperthermia
Amélie Loriaud, Alban Denys, Olivier Seror, Naik Vietti Violi, Antonia Digklia, Rafael Duran, Hervé Trillaud, Arnaud Hocquelet
PURPOSE: To compare overall local tumour progression (OLTP), defined as the failure of primary ablation or local tumour progression, with single applicator monopolar radiofrequency ablation (RFA), microwave ablation (MWA), cluster-RFA and multi-bipolar radiofrequency (mbpRFA) in the treatment of hepatocellular carcinoma (HCC) ≤ 5 cm abutting large vessels (≥3 mm). MATERIALS AND METHODS: This multicenter, retrospective, per-nodule study was performed from 2007 to 2015...
April 18, 2018: International Journal of Hyperthermia
Min Luo, Lei Shi, Fuhe Zhang, Feifan Zhou, Linglin Zhang, Bo Wang, Peiru Wang, Yunfeng Zhang, Haiyan Zhang, Degang Yang, Guolong Zhang, Wei R Chen, Xiuli Wang
BACKGROUND: Laser immunotherapy is a new anti-cancer therapy combining photothermal therapy and immunostimulation. It can eliminate the tumours by damaging tumour cells directly and promoting the release of damage-associated molecular patterns (DAMPs) to enhance tumour immunogenicity. The aim of this study was to investigate the thermal effects of laser immunotherapy and to evaluate the effectiveness and safety of laser immunotherapy for cutaneous squamous cell carcinoma (cSCC). METHODS: The cell viability and the DAMPs productions of heat-treated cSCC A431 cells in different temperatures were investigated...
April 16, 2018: International Journal of Hyperthermia
Jianming Li, Yujiang Liu, Jibin Liu, Linxue Qian
BACKGROUND: Papillary thyroid microcarcinoma (PTMC) has high incidence and low disease-specific mortality. However, active surveillance is not accepted by most patients owing to high physical or psychological pressures. The emergence of ablation technologies is supplanting traditional surgery. Our goal was to compare the clinical outcomes of microwave ablation (MWA) and surgery for T1aN0M0 PTMC. METHODS: A total of 92 consecutive patients with T1aN0M0 PTMC were studied retrospectively...
April 11, 2018: International Journal of Hyperthermia
Muneeb Ahmed, Gaurav Kumar, Svetlana Gourevitch, Tatyana Levchenko, Eithan Galun, Vladimir Torchilin, S Nahum Goldberg
PURPOSE: To determine the role of hepatic RFA heating parameters and their activation of heat shock proteins (HSPs) in modulating distant tumor growth. METHODS: First, to study effects of RFA dose on distant tumor growth, rats with subcutaneous R3230 adenocarcinoma (10 ± 1 mm) were assigned to 3 different hepatic RF doses (60°C × 10 min, 70°C × 5 min, or 90°C × 2 min) that induced identical sized ablation or sham (n = 6/arm). Post-RFA tumor growth rates, cellular proliferation (Ki-67), and microvascular density (MVD) were compared at 7 d...
April 9, 2018: International Journal of Hyperthermia
H Korkusuz, T Wolf, F Grünwald
AIM: Aim of this study was to first assess the feasibility of bipolar radiofrequency ablation in patients with parathyroid adenoma. MATERIAL AND METHODS: Bipolar RFA was performed in 9 patients with primary parathyroid adenoma in one single session. Measured parameters were PTH and calcium serum levels prior to and after bRFA. Furthermore, using an NRS pain scale (1-10), the individual, subjective maximum sensation of pain was documented. RESULTS: The bRFA resulted in a highly significant (p = 0...
April 1, 2018: International Journal of Hyperthermia
Xin Zhi, Ning Zhao, Yujiang Liu, Ji-Bin Liu, Chang Sheng Teng, Linxue Qian
OBJECTIVE: Benign thyroid nodules occur commonly but only require treatment when symptomatic. Surgical treatment, once routine, has been replaced by newer technologies, such as microwave ablation (MWA). The aim of this study was to assess the efficacy, tolerability, and cost of MWA compared to surgery to treat benign thyroid nodules. METHODS: After obtaining ethical approval and informed consent, a prospective trial was conducted with 52 patients who had symptomatic benign thyroid nodules...
March 26, 2018: International Journal of Hyperthermia
Dong Liu, Matthew S Adams, E Clif Burdette, Chris J Diederich
BACKGROUND: Stress Urinary Incontinence (SUI) is prevalent in adult women, attributed to weakened endopelvic supporting tissues, and typically treated using drugs and invasive surgical procedures. The objective of this in silico study is to explore transurethral high intensity ultrasound for delivery of precise thermal therapy to the endopelvic tissues adjacent to the mid-urethra, to induce thermal remodelling as a potential minimally invasive treatment alternative. METHODS: 3D acoustic (Rayleigh-Sommerfeld) and biothermal (Pennes Bioheat) models of the ultrasound applicator and surrounding tissues were devised...
March 22, 2018: International Journal of Hyperthermia
Dongrui Li, Zhigang Cheng, Gang Chen, Fangyi Liu, Wenbo Wu, Jie Yu, Ying Gu, Fengyong Liu, Chao Ren, Ping Liang
PURPOSE: To test the accuracy and efficacy of the multimodality imaging-compatible insertion robot with a respiratory motion calibration module designed for ablation of liver tumors in phantom and animal models. To evaluate and compare the influences of intervention experience on robot-assisted and ultrasound-controlled ablation procedures Methods: Accuracy tests on rigid body/phantom model with a respiratory movement simulation device and microwave ablation tests on porcine liver tumor/rabbit liver cancer were performed with the robot we designed or with the traditional ultrasound-guidance by physicians with or without intervention experience...
March 22, 2018: International Journal of Hyperthermia
Changwen Li, Cuiying Li, Han Ge, Mengdi Liang, Ge Ma, Lijun Ling, Hong Pan, Haiyan Gong, Hui Xie, Qiang Ding, Wenbin Zhou, Shui Wang
PURPOSE: To determine the characteristics of ultrasound (US) imaging of completely ablated cases and the effects of duration and clinical experience on accurate microwave ablation (MWA) for the treatment of benign breast tumours. METHODS: With written informed consent and approval of the institutional ethics committee, patients with symptomatic or palpable benign breast tumours (longest diameter, 7-32 mm), to whom MWA (2450 MHz) was performed, were enrolled in this prospective nonrandomised study...
March 6, 2018: International Journal of Hyperthermia
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