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International Journal of Hyperthermia

Changwen Li, Cuiying Li, Han Ge, Mengdi Liang, Ge Ma, Lijun Ling, Hong Pan, Haiyan Gong, Hui Xie, Qiang Ding, Wenbin Zhou, Shui Wang
PURPOSE: To determine thecharacteristicsof ultrasound (US) imaging of completelyablated cases and theeffects of duration and clinical experience on accurate microwave ablation (MWA) for the treatment of benign breast tumours. METHODS: With written informed consent and approval of the institutional ethics committee, patients with symptomatic or palpable benign breast tumours (longest diameter, 7-32mm), to whom MWA (2450MHz) was performed, were enrolled in this prospective nonrandomized study...
February 19, 2018: International Journal of Hyperthermia
Tian-Qi Zhang, Sen-Miao Huang, Yang-Kui Gu, Fei Gao, Zhi-Mei Huang, Xiong-Ying Jiang, Ding-Xin Liu, Jin-Hua Huang
PURPOSE: Our objective was to determine the safety and ablation size of hydrochloric acid-perfused radiofrequency ablation (HCl-RFA) in liver tissue, prospectively using in vivo rabbit and ex vivo porcine liver models. MATERIALS AND METHODS: The livers in 30 rabbits were treated in vivo with perfusions of normal saline (controls) and HCl concentrations of 5%, 10%, 15%, and 20%, during RFA at 103°C and 30 W for 3 minutes. For each experimental setting, 6 ablations were created...
February 18, 2018: International Journal of Hyperthermia
Amélie Loriaud, Alban Denys, Olivier Seror, Naik Vietti Violi, Antonia Digklia, Rafael Duran, Hervé Trillaud, Arnaud Hocquelet
PURPOSE: To compare overall local tumor progression (OLTP), defined as the failure of primary ablation or local tumor progression, with single applicator monopolar RFA, microwave ablation (MWA), cluster-RFA and multibipolar radiofrequency (mbpRFA) in the treatment of HCC≤5cm abutting large vessels (≥3mm). METHOD AND MATERIALS: This multicenter, retrospective, per-nodule study was performed from 2007 to 2015. The study was approved by the ethics review board, and informed consent was waived...
February 18, 2018: International Journal of Hyperthermia
Giovanni Mauri, Claudio Maurizio Pacella, Enrico Papini, Luca Maria Sconfienza, Luigi Solbiati
No abstract text is available yet for this article.
February 18, 2018: International Journal of Hyperthermia
Deniz Gazel, Mehmet Yılmaz
Antimicrobial chemotherapy and surgery are classical methods for treating infectious diseases. However, there is a need for alternative methods to cure infections caused by antibiotic-resistant pathogens, recurrent or chronic infections, and unreachable local infections in which the use of drugs or surgery is anatomically and physically restricted. Several microorganisms are known to be sensitive to mild hyperthermia, and this sensitivity is one of the potential benefits proposed for the host during an episode of fever...
February 15, 2018: International Journal of Hyperthermia
Xiao-Ying Zhang, Ying-Shu Guo, Jiu-Mei Chen, Jin-Juan Wang, Hong Ye, Chun-Yi Zang, Hua Duan
OBJECTIVES: To evaluate the efficacy and safety of GnRH-α pretreatment with HIFU ablation for diffuse adenomyosis. METHODS: From January 2014 to December 2016, 61 patients were divided into two groups. Twenty-three patients with larger uteri received pretreatment with GnRH-αand were then subjected to HIFU, and 38 patients underwent HIFU alone. The technical parameters included treatment time, sonication time, average sonication power, treatment intensity, total energy, non-perfusion volume (NPV) and NPV ratio...
February 15, 2018: International Journal of Hyperthermia
Jakub Mesicek, Kamil Kuca
The optimal light dose, heat generation, consequent heat spread, and an accurate thermal damage model, are key components of effective laser therapies. Recent advances in nanotechnology offer numerous possibilities on how to increase the efficacy of hyperthermia for tumour treatments. Gold nanoparticles are a promising candidate towards the achievement of this goal owing to their properties for efficiently converting light to heat. In this review, we summarise the numerical tools that are available for theoretical studies of gold-nanoparticle-mediated photo-thermal therapy...
February 15, 2018: International Journal of Hyperthermia
Syeda Nadia Shah Gilani, Akash Mehta, Alfonso Garcia-Fadrique, Babatunde Rowaiye, Veronika Jenei, Sanjeev Dayal, Kandiah Chandrakumaran, Norman Carr, Faheez Mohamed, Tom Cecil, Brendan Moran
BACKGROUND: Cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) benefits selected patients with peritoneal mesothelioma. We present the outcomes of this treatment strategy in a UK peritoneal malignancy national referral centre. METHODS: Observational retrospective analysis of data prospectively collected in a dedicated peritoneal malignancy database between March 1998 and January 2016. RESULTS: Of 1586 patients treated for peritoneal malignancy, 76 (4...
February 12, 2018: International Journal of Hyperthermia
Avinash Eranki, Navid Farr, Ari Partanen, Karun V Sharma, Christopher T Rossi, Avi Z Rosenberg, AeRang Kim, Matthew Oetgen, Haydar Celik, David Woods, Pavel S Yarmolenko, Peter C W Kim, Bradford J Wood
PURPOSE: High intensity focused ultrasound (HIFU) can non-invasively treat tumors with minimal or no damage to intervening tissues. While continuous-wave HIFU thermally ablates target tissue, the effect of hundreds of microsecond-long pulsed sonications is examined in this work. The objective of this study was to characterize sonication parameter-dependent thermomechanical bioeffects to provide the foundation for future preclinical studies and facilitate clinical translation. METHODS AND MATERIALS: Acoustic power, number of cycles/pulse, sonication time, and pulse repetition frequency (PRF) were varied on a clinical magnetic resonance imaging (MRI) - guided HIFU (MR-HIFU) system...
February 11, 2018: International Journal of Hyperthermia
Roberto Luigi Cazzato, Julien Garnon, Jean Caudrelier, Pramod Prabhakar Rao, Guillaume Koch, Afshin Gangi
No abstract text is available yet for this article.
February 8, 2018: International Journal of Hyperthermia
D Filippiadis, G Velonakis, A Mazioti, C Konstantos, E Brountzos, N Kelekis, A Kelekis
OBJECTIVES: To prospectively evaluate the effectiveness of intra-articular application of pulsed radiofrequency (PRF) combined with viscosupplementation in patients with knee osteoarthritis suffering from chronic pain refractory to conservative therapies. METHODS: During a 30-month period, PRF combined with viscosupplementation was performed on 53 cases of knee osteoarthritis (45 patients, 8/45 with bilateral knee osteoarthritis). Pre-operational imaging included standard knee X-rays on anterior-posterior and lateral views used to evaluate patients according to the Kellgren-Lawrence classification...
February 8, 2018: International Journal of Hyperthermia
Giovanni Gambelunghe, Elisa Stefanetti, Renato Colella, Massimo Monacelli, Nicola Avenia, Pierpaolo De Feo
PURPOSE: To confirm the effectiveness of laser ablation on toxic nodules in a large population with three years of follow-up. MATERIAL AND METHODS: Between 2009 and 2014, we treated 82 patients with hyperthyroidism related to the presence of a toxic nodular goiter. Patients were pre-treated pharmacologically with methimazole prior to single session of laser ablation (LA) and then followed up every 3 months with FT4 and TSH blood tests as well as ultrasound examination of the nodules treated...
February 6, 2018: International Journal of Hyperthermia
Siyuan Zhang, Ranxiang Xu, Shaoqiang Shang, Yuqiang Han, Sihao Liu, Tianqi Xu, Chunming Gu, Xingguang Zhu, Gang Niu, Mingxi Wan
In this study, the feasibility of using ultrasonic differential attenuation coefficient intercept (Δα0) imaging to evaluate thermal lesions induced by microwave ablation (MWA) was explored using an in vivo porcine model. The attenuation coefficient intercept (α0) is defined as the attenuation coefficient at the center frequency of the ultrasound transmitted pulse. Δα0 is estimated by subtracting an initial value of α0 from the value calculated during MWA. Thermal lesions were induced in the livers (N = 9) and kidneys (N = 7) of five domestic pigs using a clinical MWA system...
February 6, 2018: International Journal of Hyperthermia
Ra Gyoung Yoon, Jung Hwan Baek, Sae Rom Chung, Young Jun Choi, Jeong Hyun Lee
PURPOSE: This study evaluated the characteristics of a thyroid-dedicated bipolar RF electrode (BRFE) and compared its ablation performance with that of monopolar RF electrodes (MRFEs) in normal bovine liver blocks Methods: BRFE was tested on 60 bovine liver blocks with six different time-power combinations, applying 20, 30, and 40 watts (W) for 60 and 120 seconds (sec). Subsequently, BRFE and MRFEs with 0.5-, 0.7- and 1-cm active tips were applied on 160 bovine liver blocks, creating 16 time-electrode combinations (10, 30, 60, 120 sec)...
February 6, 2018: International Journal of Hyperthermia
Chunlin Jiang, Baoxian Liu, Shuling Chen, Zhenwei Peng, Xiaoyan Xie, Ming Kuang
PURPOSE: To analyse the precise ablative margin (AM) after radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC) and the correlation between AM and local tumour progression (LTP) with a three-dimension (3D) reconstruction technique. METHODS: From March 2011 to May 2013, 134 patients who underwent RFA for 159 primary or recurrent HCCs within Milan criteria were enrolled. Contrast-enhanced computed tomography (CECT) scans were performed 1 week before and 1 month after treatment...
February 2, 2018: International Journal of Hyperthermia
Juan J Pérez, Ana González-Suárez, Andre d'Avila, Enrique Berjano
PURPOSE: Although bipolar radiofrequency (RF) ablation (RFA) is broadly used to eliminate ventricular tachycardias in the interventricular septum wall, it can fail to create transmural lesions in thick ventricular walls. To solve this problem, we explored whether an RF-energized guidewire inserted into the ventricular wall would enhance bipolar RFA in the creation of transmural lesions through the ventricular wall. METHODS: We built three-dimensional computational models including two irrigated electrodes placed on opposing sides of the interventricular septum and a metal guidewire inserted into the septum...
February 2, 2018: International Journal of Hyperthermia
Wang Yao, Mingjian Lu, Wenzhe Fan, Jinhua Huang, Yangkui Gu, Fei Gao, Yu Wang, Jiaping Li, Zhihua Zhu
PURPOSE: To compare the effectiveness and complication between microwave ablation and lobectomy for stageInon-small cell lung cancer. MATERIALS AND METHODS: This retrospective study was approved by two institutional ethics committees and all patients were provided with informed consent. From January 2000 to December 2010, 54 and 795 stageIpatients who underwent microwave ablation and lobectomy were included in this study. A matched cohort composed of 54 and 108 patients in the microwave ablation and the lobectomy group were selected after adjustment with 1:2 propensity score matching...
January 30, 2018: International Journal of Hyperthermia
Pierre Bour, Valéry Ozenne, Fabrice Marquet, Baudouin Denis de Senneville, Erik Dumont, Bruno Quesson
INTRODUCTION: MRgHIFU treatments of mobile organs require locking the HIFU beam on the targeted tissue to maximize heating efficiency. We propose to use a standalone 3D ultrasound-based motion correction technique using the HIFU transducer in pulse-echo mode. Validation of the method was performed in vitro and in vivo in the liver of pig under MR-Thermometry. METHODS: 3D-motion estimation was implemented using ultrasonic speckle-tracking between consecutive acquisitions...
January 29, 2018: International Journal of Hyperthermia
Jing Yan, Tihong Qiu, Jing Lu, Yanjun Wu, Yinghong Yang
OBJECTIVE: In this study, we compared the systemic stress response induced by microwave ablation with that induced by conventional open surgery for treatment of benign thyroid nodules. METHODS: A total of 108 patients with benign thyroid nodules were randomly assigned to receive ultrasound-guided thyroid microwave ablation (microwave group, n = 57) and conventional open thyroid surgery (open group, n = 51). Body temperature, white blood cell (WBC) counts, visual analogue scale (VAS) scores for pain, and serum levels of high sensitive C-reactive protein (hs-CRP), interleukin 6 (IL-6) and cortisol were measured at 24 h before operation and at 8 h, 24 h and 48 h after operation...
January 24, 2018: International Journal of Hyperthermia
R Cesareo, A M Naciu, M Iozzino, V Pasqualini, C Simeoni, A Casini, G Campagna, S Manfrini, G Tabacco, A Palermo
CONTEXT: No defined pretreatment factors are able to predict the response to radiofrequency ablation(RFA) of an autonomously functioning thyroid nodule(AFTN). OBJECTIVE: primary endpoint was to evaluate the success rate of RFA to restore euthyroidism in a cohort of adult patients with small solitary AFTN compared with medium-sized nodules. Secondary endpoints included nodule volume reduction and rate of conversion from hot nodules to cold using scintiscan. METHODS: This was a 24-month prospective monocentric open parallel-group trial...
January 22, 2018: International Journal of Hyperthermia
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