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International Journal of Hyperthermia

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https://www.readbyqxmd.com/read/28166655/comment-on-effectiveness-of-ultrasound-guided-percutaneous-microwave-ablation-for-symptomatic-uterine-fibroids-a-multicenter-study-in-china
#1
Salman Khazaei, Erfan Ayubi, Shahrzad Nematollahi, Kamyar Mansori
No abstract text is available yet for this article.
February 6, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28100096/targeting-therapy-resistant-cancer-stem-cells-by-hyperthermia
#2
A L Oei, L E M Vriend, P M Krawczyk, M R Horsman, N A P Franken, J Crezee
Eradication of all malignant cells is the ultimate but challenging goal of anti-cancer treatment; most traditional clinically-available approaches fail because there are cells in a tumour that either escape therapy or become therapy-resistant. A subpopulation of cancer cells, the cancer stem cells (CSCs), is considered to be of particular significance for tumour initiation, progression and metastasis. CSCs are considered in particular to be therapy-resistant and may drive disease recurrence, which positions CSCs in the focus of anti-cancer research, but successful CSC-targeting therapies are limited...
February 2, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28142288/update-on-clinical-trials-in-colorectal-cancer-peritoneal-metastasis
#3
Amandine Pinto, Clarisse Eveno, Marc Pocard
BACKGROUND/PURPOSE: Peritoneal metastases (PM) arising from colorectal cancer (CRC) can be treated using cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) in select patients. OBJECTIVE: To review clinical trials that were reported during the 10(th) International Congress on Peritoneal Surface Malignancies and dedicated to the treatment of CRC-PM. METHODS: Ten clinical trials were presented at the 10(th) PSOGI meeting in November 2016 in Washington DC...
January 31, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28139939/effect-of-capacitive-and-resistive-electric-transfer-on-hemoglobin-saturation-and-tissue-temperature
#4
Yuto Tashiro, Satoshi Hasegawa, Yuki Yokota, Shu Nishiguchi, Naoto Fukutani, Hidehiko Shirooka, Seishiro Tasaka, Tomofumi Matsushita, Keisuke Matsubara, Yasuaki Nakayama, Takuya Sonoda, Tadao Tsuboyama, Tomoki Aoyama
PURPOSE: This study aims to evaluate the effects of Capacitive and Resistive electric transfer (CRet) and hotpack (HP) on hemoglobin saturation and tissue temperature. MATERIALS AND METHODS: The participants were 13 healthy males (mean age 24.5 ± 3.0). They underwent three interventions on different days: (1) CRet (CRet group), (2) HP (HP group) and (3) CRet without power (sham group). The intervention and measurement were applied at the lower paraspinal muscle...
January 31, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28049386/quality-assurance-guidelines-for-superficial-hyperthermia-clinical-trials-i-clinical-requirements
#5
Hana Dobšíček Trefná, Hans Crezee, Manfred Schmidt, Dietmar Marder, Ulf Lamprecht, Michael Ehmann, Josefin Hartmann, Jacek Nadobny, Johanna Gellermann, Netteke van Holthe, Pirus Ghadjar, Nicoletta Lomax, Sultan Abdel-Rahman, Christoph Bert, Akke Bakker, Mark D Hurwitz, Chris J Diederich, Paul R Stauffer, Gerard C van Rhoon
Quality assurance guidelines are essential to provide uniform execution of clinical trials and treatment in the application of hyperthermia. This document provides definitions for a good hyperthermia treatment and identifies the clinical conditions where a certain hyperthermia system can or cannot adequately heat the tumour volume. It also provides brief description of the characteristics and performance of the current electromagnetic (radiative and capacitive), ultrasound and infra-red heating techniques. This information helps to select the appropriate heating technique for the specific tumour location and size, and appropriate settings of the water bolus and thermometry...
January 31, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28044461/equivalence-of-cell-survival-data-for-radiation-dose-and-thermal-dose-in-ablative-treatments-analysis-applied-to-essential-tremor-thalamotomy-by-focussed-ultrasound-and-gamma-knife
#6
D Schlesinger, M Lee, G Ter Haar, B Sela, M Eames, J Snell, N Kassell, J Sheehan, J M Larner, J-F Aubry
Thermal dose and absorbed radiation dose have historically been difficult to compare because different biological mechanisms are at work. Thermal dose denatures proteins and the radiation dose causes DNA damage in order to achieve ablation. The purpose of this paper is to use the proportion of cell survival as a potential common unit by which to measure the biological effect of each procedure. Survival curves for both thermal and radiation doses have been extracted from previously published data for three different cell types...
January 31, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28124576/current-status-and-future-prospects-of-clinical-trials-on-crs-hipec-for-gastric-cancer-peritoneal-metastases
#7
Zhong-He Ji, Kai-Wen Peng, Yang Yu, Xin-Bao Li, Yutaka Yonemura, Yang Liu, Paul H Sugarbaker, Yan Li
PURPOSE: There is no standard treatment for peritoneal metastases (PM) from gastric cancer (GC). The aim of this review is to evaluate the clinical trials on cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) for GC PM. MATERIALS AND METHODS: The published clinical trials on CRS + HIPEC for GC PM are critically evaluated, and survival and safety are the primary endpoints. In addition, the registered ongoing clinical trials are summarized...
January 26, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28118773/percutaneous-microwave-ablation-with-artificial-ascites-for-symptomatic-uterine-adenomyosis-initial-experience
#8
Ning Hai, Jing Zhang, Ruifang Xu, Zhi-Yu Han, FangYi Liu
PURPOSE: To evaluate the feasibility, safety and technical efficacy of ultrasound-guided percutaneous microwave ablation with artificial ascites for adenomyosis. MATERIALS AND METHODS: Between May 2015 and May 2016, a total of 25 patients with symptomatic adenomyosis who underwent ultrasound-guided percutaneous microwave ablation with artificial ascites were included in this retrospective study. A matching cohort of 50 patients underwent ultrasound-guided percutaneous microwave ablation without artificial ascites as controls...
January 24, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28114851/theoretical-and-experimental-analysis-of-amplitude-control-ablation-and-bipolar-ablation-in-creating-linear-lesion-and-discrete-lesions-for-treating-atrial-fibrillation
#9
Shengjie Yan, Xiaomei Wu, Weiqi Wang
PURPOSE: Radiofrequency (RF) energy is often used to create a linear lesion or discrete lesions for blocking the accessory conduction pathways for treating atrial fibrillation. By using finite element analysis, we study the ablation effect of amplitude control ablation mode (AcM) and bipolar ablation mode (BiM) in creating a linear lesion and discrete lesions in a 5-mm-thick atrial wall; particularly, the characteristic of lesion shape has been investigated in amplitude control ablation...
January 23, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28049374/needle-track-seeding-after-percutaneous-radiofrequency-ablation-of-hepatocellular-carcinoma-14-year-experience-at-a-single-centre
#10
Zhang Zhong-Yi, Yang Wei, Yan Kun, Dai Ying, Wu Wei, Lee Jung-Chieh, Chen Min-Hua
PURPOSE: To determine the incidence, risk factors and prognosis associated with needle track seeding after percutaneous radiofrequency ablations (RFA) for hepatocellular carcinoma (HCC) with a long-term follow-up. MATERIALS AND METHODS: A total of 741 HCC patients undergoing percutaneous RFA were retrospectively analysed. Mean follow-up interval was 34.3 ± 26.8 months. All seeding neoplasms were diagnosed by imaging modalities with or without pathological evaluation...
January 23, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28111999/enhancement-of-hyperthermia-induced-apoptosis-by-5z-7-oxozeaenol-a-tak1-inhibitor-in-molt-4-cells
#11
Peng Li, Qing-Li Zhao, Paras Jawaid, Mati Ur Rehman, Kanwal Ahmed, Hiroaki Sakurai, Takashi Kondo
PURPOSE: Transforming growth factor-β-activated kinase1 (TAK1) plays an anti-apoptotic role in response to multiple stresses. TAK1 inhibitor, 5Z-7-oxozeaenol (OZ) has been studied for its apoptotic effects. However, the combined effect of OZ with physical stresses remains to be elusive. Therefore, in this study we focussed to determine the combined effects of OZ with hyperthermia (HT) using Molt-4 cell line. MATERIALS AND METHODS: Molt-4 cells were pre-treated with OZ for 1 h followed by heat exposure (44 °C, 10 min) and harvested 24 h after incubation at 37 °C, apoptosis was measured by Annexin V-FITC/PI double staining assay using flow cytometry and cell growth was observed by cell counting assay...
January 22, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28110582/the-effect-of-perfusate-buffering-on-toxicity-and-response-in-isolated-hepatic-perfusion-for-uveal-melanoma-liver-metastases
#12
Ilan Ben-Shabat, Valerio Belgrano, Christoffer Hansson, Bagge Roger Olofsson
BACKGROUND: Isolated hepatic perfusion (IHP) is a treatment option for patients with liver metastases. Previous studies have found that liver toxicity is one of the limiting factors, and in an attempt to reduce the toxicity a buffering agent was added to the perfusate. The aim was to retrospectively analyze if this buffering reduced toxicity and complication rates. METHODS: A retrospective review of 52 consecutive patients with uveal melanoma liver metastases treated with IHP between 2005-2013...
January 22, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28110576/preclinical-evaluation-of-an-mr-compatible-microwave-ablation-system-and-comparison-with-a-standard-microwave-ablation-system-in-an-ex-vivo-bovine-liver-model
#13
Rüdiger Hoffmann, David-Emanuel Kessler, Jakob Weiss, Stephan Clasen, Philippe L Pereira, Konstantin Nikolaou, Hansjörg Rempp
OBJECTIVE: Evaluation of a newly developed MR-compatible microwave ablation system with focus on ablation performance and comparison with a corresponding standard microwave ablation system. MATERIALS AND METHODS: 52 ablations were performed with a non-cooled microwave ablation system in an ex vivo bovine liver model using the following settings: [A] 16G-standard antenna, 2cm active tip, 2.4m cable; [B] MR-compatible 16G-antenna, 2cm active tip, 2.4m cable; [C] MR-compatible 16G-antenna, 2cm active tip, extended 6m cable; [D] MR-compatible 16G-antenna, 4cm active tip, extended 6m cable...
January 22, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28100078/percutaneous-microwave-ablation-mwa-increased-the-serum-levels-of-vegf-and-mmp-9-in-stage-i-non-small-cell-lung-cancer-nsclc
#14
Yang Ni, Xin Ye, Chao Wan, Qing Ni, Xia Yang, Guanghui Huang, Wenhong Li, Jiao Wang, Xiaoying Han, Zhigang Wei, Min Meng
BACKGROUND: Lung cancer is the leading cause of cancer death around the world. Percutaneous microwave ablation (MWA) is an emerging treatment strategy for medically inoperable early stage non-small cell lung cancer (NSCLC). In this study, we investigated the association of MWA and serum angiogensis promoters VEGF and MMP-9 in these patients subgroup. METHODS: We enrolled 52 patients with stage I NSCLC patients in this study. For each patient, blood samples were drawn by venous puncture, one immediately prior to MWA and the others on post-procedure days (PPD) 1, 3, 5, 7, 10 and 14...
January 18, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28093005/cardiac-and-respiratory-effects-of-deep-regional-hyperthermia-using-an-8-mhz-radiofrequency-capacitive-device-on-patients-with-cancer
#15
Rieko Izukura, Hajime Imada, Nobuko Hashiguchi, Hiroyuki Sawatari, Takayuki Ohguri, Mami Miyazono, Shin Ohta, Chizuko Takakura, Keiko Yamasaki, Chie Magota, Kanae Fujita, Hiromi Kuroda, Hideki Hirata, Tomoko Ohkusa, Akiko Chishaki
PURPOSE: Hyperthermia (HT), an adjuvant therapy for variable cancers, may cause physiological changes in the patients, which may lead to cardiovascular problems. Among various HT treatments, the physiological effects of deep regional HT are still unclear. We examined the physiological alterations throughout deep regional HT to improve the HT safety. MATERIALS AND METHODS: Thirty-one patients (age: 61±12 years) with cancer received HT in the thoracic or upper abdominal regions using an 8-MHz radiofrequency-capacitive-device for 50 min...
January 16, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28092994/current-status-and-future-prospects-of-hyperthermic-intraoperative-intraperitoneal-chemotherapy-hipec-clinical-trials-in-ovarian-cancer
#16
Renee A Cowan, Roisin E O'Cearbhaill, Oliver Zivanovic, Dennis S Chi
The natural history of advanced-stage epithelial ovarian cancer is one of clinical remission after surgery and platinum/taxane-based intravenous and/or intraperitoneal chemotherapy followed by early or late recurrence in the majority of patients. Prevention of progression and recurrence remains a major hurdle in the management of ovarian cancer. Recently, many investigators have evaluated the use of normothermic and hyperthermic intraoperative intraperitoneal drug delivery as a management strategy. This is a narrative review of the current status of clinical trials of hyperthermic intraoperative intraperitoneal chemotherapy (HIPEC) in ovarian cancer and the future directions for this treatment strategy...
January 16, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28081645/factors-related-to-recurrence-of-the-benign-non-functioning-thyroid-nodules-after-percutaneous-microwave-ablation
#17
Bei Wang, Zhi-Yu Han, Jie Yu, Zhigang -Cheng, Fangyi Liu, Xiao-Ling Yu, Chaonan Chen, Ju Liu, Ping Liang
PURPOSE: To determine the factors affecting the recurrence of the solitary benign thyroid nodules (BTN) after microwave ablation (MWA). MATERIALS AND METHODS: Between January 2013 and January 2015, a total of 110 patients with at least one solid thyroid nodule (solid component ≥ 80%) were enrolled. MWA was performed under continuous ultrasound (US) guidance. Before and during the follow-up, the thyroid nodule volume, thyroid function and cosmetic complaints were evaluated...
January 12, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28064557/compact-self-grounded-bow-tie-antenna-design-for-an-uwb-phased-array-hyperthermia-applicator
#18
Pegah Takook, Mikael Persson, Johanna Gellermann, Hana Dobšíček Trefná
Using UWB hyperthermia systems has the potential to improve the heat delivery to deep seated tumours. In this paper, we present a novel self-grounded Bow-Tie antenna design which is to serve as the basis element in a phased-array applicator. The UWB operation in the frequency range of 0.43-1 GHz is achieved by immersing the antenna in a water bolus. The radiation characteristics are improved by appropriate shaping the water bolus and by inclusion of dielectric layers on the top of the radiating arms of the antenna...
January 8, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28044471/percutaneous-thermal-ablation-for-the-treatment-of-colorectal-liver-metastases-and-hepatocellular-carcinoma-a-comparison-of-local-therapeutic-efficacy
#19
Ming Liu, Guang-Liang Huang, Ming Xu, Fu-Shun Pan, Ming-de Lu, Ke-Guo Zheng, Ming Kuang, Xiao-Yan Xie
AIM: This study aimed to compare the local therapeutic efficacy of percutaneous thermal ablation for colorectal liver metastases (CRLM) and hepatocellular carcinoma (HCC). METHODS: One hundred sixty-one CRLM nodules in 101 patients and 122 HCC nodules in 97 patients were treated with thermal ablation. Complications and local efficacy were retrospectively compared. RESULTS: Major complications were observed in 2 (2.0%) patients in the CRLM group and 1 (1...
January 3, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/27829290/hsp90-inhibitors-in-the-context-of-heat-shock-and-the-unfolded-protein-response-effects-on-a-primary-canine-pulmonary-adenocarcinoma-cell-line
#20
Arin N Graner, Justin E Hellwinkel, Alex M Lencioni, Helen J Madsen, Tessa A Harland, Paul Marchando, Ger J Nguyen, Mary Wang, Laura M Russell, Lynne T Bemis, Thomas J Anchordoquy, Michael W Graner
BACKGROUND: Agents targeting HSP90 and GRP94 are seldom tested in stressed contexts such as heat shock (HS) or the unfolded protein response (UPR). Tumor stress often activates HSPs and the UPR as pro-survival mechanisms. This begs the question of stress effects on chemotherapeutic efficacy, particularly with drugs targeting chaperones such as HSP90 or GRP94. We tested the utility of several HSP90 inhibitors, including PU-H71 (targeting GRP94), on a primary canine lung cancer line under HS/UPR stress compared to control conditions...
December 20, 2016: International Journal of Hyperthermia
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