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International Journal of Hyperthermia

Ken Ando, Yoshiyuki Suzuki, Takuya Kaminuma, Yuya Yoshimoto, Takahiro Oike, Noriyuki Okonogi, Hiro Sato, Tomoaki Tamaki, Shin-Ei Noda, Kosaku Mimura, Takashi Nakano
PURPOSE: This study aimed to elucidate the contribution of T cell-mediated antitumor immunity in the antitumor effect of local hyperthermia (LH). MATERIALS AND METHODS: C57BL/6J mice were injected with the mouse lymphoma cell line, E.G7-OVA, in the right femur on day 0. LH was induced by immersing the right femur in a water bath at 42 °C for 60 min on day 7, followed by administration of anti-CD8 monoclonal antibodies (mAb) or anti-CTLA-4 mAb (days 8, 11, and 14)...
September 17, 2018: International Journal of Hyperthermia
Chaitanya Pandit, S Sai Latha, T Usha Rani, K R Anilakumar
Despite an understanding that a major effect of cold exposure is a fall in core body temperature which is responsible for the observed decrements in the performance, it is surprising that thermogenic supplements are seldom evaluated to verify if they can aid in improving the performance during cold exposure. Following evidence from our previous study indicating the ability of pepper and cinnamon to improve cold endurance, we investigated further here if the improved endurance had advantages in real time where they could positively affect cognitive performance (assessed by Novel object test) when exposed to cold in albino wistar rats...
September 13, 2018: International Journal of Hyperthermia
Fabrice Bing, Jonathan Vappou, Michel de Mathelin, Afshin Gangi
PURPOSE: To retrospectively evaluate the suitability of MRgHIFU for osteoid osteomas (OOs) and bone metastases in patients who underwent minimally-invasive percutaneous thermal ablation. MATERIALS AND METHODS: One hundred and sixty-seven lesions (115 metastases and 52 OOs) treated percutaneously between October 2014 and June 2017 were retrospectively analyzed. Tumors were located in the spine or sacrum (54), pelvis (43), limbs (50), ribs (17) and sternum (3). Tumor volume, matrix, anatomical environment and need for protection of surrounding structures or consolidation were assessed...
September 13, 2018: International Journal of Hyperthermia
Ling Zhao, Youlin Deng, Qing Wei, Jinyun Chen, Chunquan Zhao
BACKGROUND: Surgery constitutes the standard approach for abdominal wall endometriosis (AWE), but is invasive. High-intensity focused ultrasound (HIFU) ablation is effective and safe for the treatment of AWE, but no study has compared HIFU and surgery. OBJECTIVE: To report our experience about the benefits and adverse events of surgery compared to HIFU for the treatment of AWE. METHODS: This was a retrospective study of 54 consecutive Chinese women with AWE after cesarean section treated at the First Affiliated Hospital of Chongqing Medical University (China) between January 2012 and December 2014...
September 13, 2018: International Journal of Hyperthermia
Min Ding, Sicong Ma, Xiaoyin Tang, Tao Wang, Xingxing Qi, Jiachang Chi, Zhi Wang, Dan Cui, Yaoping Shi, Yuan Zhang, Ping Li, Bo Zhai
PURPOSE: Acute kidney injury (AKI), especially oliguric AKI, is a recognized complication following microwave ablation (MWA) of large liver tumors. This study evaluated the clinical features, mechanisms, risk factors and prevention strategies for oliguric AKI after MWA of large liver tumors. METHODS: From March 2011 to May 2015, 441 patients with liver tumors ≧5 cm received MWA in our hospital. The clinical features, prevention strategies, further mechanisms and possible risk factors for oliguric AKI after MWA were analyzed...
September 11, 2018: International Journal of Hyperthermia
M Hahn, R Fugunt, B Schoenfisch, E Oberlechner, I V Gruber, U Hoopmann, C Roehm, G Helms, F A Taran, A D Hartkopf, H Warzecha, B Wiesinger, S Y Brucker, B Boeer
PURPOSE: The aim of the study was to evaluate the efficacy of high intensity focused ultrasound (HIFU) in the treatment of symptomatic breast fibroadenomas (FA) after 6 and 12 months. MATERIALS AND METHODS: Between December 2013 and November 2014, 27 patients with histologically confirmed FA received one application of HIFU under local anesthesia (NCT02011919). Follow-up visits occurred after 6 and 12 months measuring the FA volume and clinical symptoms. A volume reduction of more than 65% was defined as success...
September 11, 2018: International Journal of Hyperthermia
Bernard Lamien, Rangel Barreto Helcio Orlande, Antonio Bermeo Leonardo Varón, Leite Queiroga Rodrigo Basto, Enrique Guillermo Eliçabe, Silva Dilson Dos Santos, Machado Renato Cotta
BACKGROUND: One of the challenges faced during the hyperthermia treatment of cancer is to monitor the temperature distribution in the region of interest. The main objective of this work was to accurately estimate the transient temperature distribution in the heated region, by using a stochastic heat transfer model and temperature measurements. METHODS: Experiments involved the laser heating of a cylindrical phantom, partially loaded with iron oxide nanoparticles...
September 11, 2018: International Journal of Hyperthermia
Lorenzo Monfardini, Franco Orsi, Rosalba Caserta, Claudio Sallemi, Paolo Della Vigna, Guido Bonomo, Gianluca Varano, Luigi Solbiati, Giovanni Mauri
PURPOSE: To assess the feasibility of fusion imaging between intraprocedural ultrasound (US) and contrast-enhanced cone-beam CT (CBCT) for small (< 2 cm) hepatocellular carcinoma (HCC). MATERIALS AND METHODS: Six patients (five males, one female, age range 58-80, mean 69 years), with small (mean diameter 16.8 mm) HCC poorly visible at US underwent percutaneous microwave ablation under US/CBCT fusion guidance. During general anesthesia with apnea control, a contrast- enhanced CBCT was acquired with an active tracker...
September 11, 2018: International Journal of Hyperthermia
Hendrik Thijmen Mulder, Sergio Curto, Margarethus Marius Paulides, Martine Franckena, Gerard C van Rhoon
BACKGROUND: Radiofrequency (RF) mild hyperthermia (40 °C-44 °C for 60 minutes) is an effective adjuvant treatment for several types of cancer. To ensure treatment efficacy, quality assurance (QA) is necessary. This study presents the first systematic 3D characterisation of the heating performance of the commonly used Pyrexar BSD2000-3D MR-compatible hyperthermia applicator using magnetic resonance temperature imaging (MRTI). METHODS: A reproducibly positioned phantom was heated with a power of 1000 watts during the 12...
September 11, 2018: International Journal of Hyperthermia
Agnese Persichetti, Giancarlo Bizzarri, Rinaldo Guglielmi, Agnese Barnabei, Antonio Bianchini, Carmela Coccaro, Marialuisa Appetecchia, Enrico Papini
BACKGROUND: Surgery is the standard treatment for cervical metastases of medullary thyroid cancer (MTC) diagnosed after initial surgical treatment. Repeated neck dissections, however, carry an elevated risk of complications, have an adverse impact on the quality of life, and sometimes do not achieve cure of the disease Clinical case: In a patient who had undergone two cervical neck dissections complicated by accessory nerve injury, an US-guided laser ablation (LA) of a lymph node metastasis of MTC was performed...
September 11, 2018: International Journal of Hyperthermia
Wei Cui, Wenzhe Fan, Kunbo Huang, Yu Wang, Mingjian Lu, Wang Yao, Jiaping Li
PURPOSE: To evaluate the safety and efficacy of transarterial chemoembolization (TACE) combined with cryoablation (TACE-cryoablation) in large (main tumor ≥5 cm in diameter) hepatocellular carcinomas (HCCs). METHODS: From January 2010 to December 2015, 56 lesions in 56 patients were treated with combination therapy via a single TACE session followed by one to three percutaneous cryoablation sessions twice a week (TACE-cryoablation group). A total of 54 lesions in 54 patients were treated with TACE alone for two to six sessions once a month (TACE group)...
September 10, 2018: International Journal of Hyperthermia
Xiu-Mei Bai, Wei Yang, Zhong-Yi Zhang, An-Na Jiang, Wei Wu, Jung-Chieh Lee, Min-Hua Chen, Kun Yan
OBJECTIVE: To evaluate the long-term efficacy and prognostic factors of ultrasound-guided percutaneous radiofrequency ablation (RFA) for breast cancer liver metastasis (BCLM). METHODS: Between 2000 and 2015, 69 patients who underwent ultrasound-guided percutaneous RFA for BCLM and had regular follow-up examinations were included. All patients had undergone resection of the primary breast cancer and had received chemotherapy, endocrine therapy or both after surgery...
September 10, 2018: International Journal of Hyperthermia
Yuqi Zhang, Cai Zhang, Jia He, Jin Bai, Lian Zhang
OBJECTIVE: To evaluate the correlation between the gestational sac size and the effect and safety of high intensity focused ultrasound (HIFU) combined with ultrasound-guided suction curettage for caesarean scar pregnancy (CSP). METHODS: Seventy-six patients with CSP were enrolled. Based on their gestational sac size, patients were divided into three groups: Group 1 (n = 16, 10-20 mm), Group 2 (n = 28, 21-30 mm) and Group 3 (n = 32, >30 mm). All of them were treated by HIFU combined with ultrasound-guided suction curettage...
September 10, 2018: International Journal of Hyperthermia
Hao Jin, Jinrui Fan, Kun Liao, Zhuocheng He, Wei Li, Min Cui
PURPOSE: Our study aims to compare ultrasound (US)-guided percutaneous microwave ablation (PMWA) and conventional thyroidectomy in benign thyroid nodules (BTN) treatment. MATERIALS AND METHODS: From December 2015 to December 2017, a total of 280 patients with at least one benign thyroid nodule were studied retrospectively, including 156 patients treated with US-guided PMWA and 124 patients treated with conventional thyroidectomy. Propensity score matching was performed to decrease the confounding bias due to retrospective assignment and to balance the pre-operation data of the two groups...
September 3, 2018: International Journal of Hyperthermia
Zhi Wang, Xiaoyin Tang, Xingxing Qi, Yaoping Shi, Jiachang Chi, Ping Li, Bo Zhai
BACKGROUND: Hepatic hemangioma is a common benign liver tumor. The majority of cases are asymptomatic and require no specific treatment. The aim of this study was to evaluate the feasibility, safety and efficacy of microwave ablation (MWA) for symptomatic or enlarging giant hepatic hemangioma (≥10 cm). METHODS: From December 2013 to June 2016, 12 patients with giant hepatic hemangioma (≥10 cm) underwent ultrasound-guided percutaneous MWA, and ablation-related complications were observed...
August 21, 2018: International Journal of Hyperthermia
Vivek K Nagarajan, Venkateswara R Gogineni, Sarah B White, Bing Yu
Complete ablation of liver tumors is vital for minimizing the risk of local tumor recurrence. Accurately identifying the hallmarks of tissue necrosis during thermal ablative therapies may significantly increase the efficacy of ablation, while minimizing unnecessary damage to the surrounding normal tissues or critical structures. Light propagation in biological tissues is sensitive to the tissue microstructure and chromophore concentrations. In our previous studies, we found that the wavelength (λ) averaged liver tissue absorption coefficient (µa ) and reduced scattering coefficient (µs ') change significantly upon heating which may be used for assessment of tissue damage during thermal ablation of solid tumors...
August 21, 2018: International Journal of Hyperthermia
Yeqian Huang, Nayef A Alzahrani, Winston Liauw, Arief Arrowaili, David L Morris
BACKGROUND: It is believed that the oncologic behavior of mucinous colorectal adenocarcinoma (MC) is different from non-mucinous adenocarcinoma (NMC). The aim of the study is to compare long-term survivals between patients with MC and those with NMC following cytoreductive surgery (CRS) and intraperitoneal chemotherapy (IPC). METHODS: This was a retrospective study of prospectively collected data of patients with peritoneal metastases of colorectal origin following CRS and IPC...
August 21, 2018: International Journal of Hyperthermia
Jinshun Xu, Han Wu, Zhiyu Han, Jing Zhang, Qinying Li, Jianping Dou, Chao An, Erpeng Qi, Jie Yu, Ping Liang
PURPOSE: This prospective study was to evaluate clinical outcomes of microwave ablation (MWA) of benign breast tumors with minimum 12 months follow up. METHODS: With approval of the institutional ethics committee and written informed consent, 56 patients with 107 biopsy-proved breast benign tumors were recruited from November, 2013 to April, 2017. MWA with ultrasound (US) guidance was performed under local anesthesia. During the procedure, pull-back technique was used for tumors larger than 1...
August 21, 2018: International Journal of Hyperthermia
Stella Bernardi, Chiara Dobrinja, Anna Carere, Fabiola Giudici, Veronica Calabrò, Fabrizio Zanconati, Nicolò de Manzini, Bruno Fabris, Fulvio Stacul
INTRODUCTION: Minimally invasive nonsurgical techniques are gaining ground as alternatives to surgery for the treatment of benign thyroid nodules. Here, we aimed at comparing patient satisfaction after radiofrequency ablation (RFA) to that after surgery. METHODS: In this cross-sectional study, we recruited 126 patients treated with RFA and 84 treated with surgery for a single benign thyroid nodule. All patients were contacted by phone call and were asked the following questions: Are you satisfied with the symptom resolution?; Are you satisfied with the cosmetic results?; Are you satisfied overall with the procedure?; Are you taking any medication for your thyroid? Patients' general characteristics were collected from our database...
August 15, 2018: International Journal of Hyperthermia
Giovanni Turtulici, Davide Orlandi, Giorgia Dedone, Giovanni Mauri, Alessandro Fasciani, Rodolfo Sirito, Enzo Silvestri
PURPOSE: The purpose of this study was to assess the feasibility and outcome of transvaginal ultrasound (US)-guided radiofrequency ablation of uterine fibroids assisted by a real-time virtual needle tracking (VT) system. METHODS: Between January 2017 and February 2018, 19 patients (age 45 ± 8 y, range 36-53 y) with 25 symptomatic uterine fibroids underwent transvaginal radiofrequency ablation (RFA) at a single center. Mean number of fibroids for patient was 1...
July 17, 2018: International Journal of Hyperthermia
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