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International Journal of Hyperthermia

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https://www.readbyqxmd.com/read/27817240/microwave-ablation-versus-hepatic-resection-for-the-treatment-of-hepatocellular-carcinoma-and-oesophageal-variceal-bleeding-in-cirrhotic-patients
#1
Qiang-Bo Zhang, Xiu-Guo Zhang, Run-de Jiang, Chun-Xiao Hu, Dong Sun, Lin Ran, Zong-Li Zhang
PURPOSE: The aim of this study was to compare the results of microwave ablation (MWA) and hepatic resection (HR) when combined with pericardial devascularisation plus splenectomy (PCDV) for the treatment of patients with cirrhosis complicated by small hepatocellular carcinoma (HCC) and oesophageal variceal bleeding (EVB). MATERIALS AND METHODS: Between 2001 and 2013, 73 patients (median age 53.2 years, 67% male) with small HCC and concomitant EVB who underwent MWA or HR for HCC and PCDV for cirrhotic portal hypertension were selected retrospectively for inclusion in this study...
December 8, 2016: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/27868461/a-new-approach-to-feedback-control-of-radiofrequency-ablation-systems-for-large-coagulation-zones
#2
Bing Zhang, Michael A J Moser, Edwin M Zhang, Yigang Luo, Wenjun Zhang
AIM: The aim of this study was to investigate the feasibility of achieving relatively large coagulation zones (i.e. ≥3 cm in diameter) with radiofrequency ablation (RFA) by using a broad control system. MATERIALS AND METHODS: A broad control system consists of information such as (i) the area of the tumour tissue for feedback control, (ii) the set-point temperature and (iii) the control law. The proposed approach has advanced knowledge in (i) and (ii) in particular...
December 6, 2016: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/27919181/treatment-of-peritoneal-metastases-from-small-bowel-adenocarcinoma
#3
Koen P Rovers, Eelco de Bree, Yutaka Yonemura, Ignace H de Hingh
BACKGROUND/PURPOSE: Peritoneal metastases (PM) affect approximately one third of patients with metastatic small bowel adenocarcinoma (SBA). Treatment options are (1) systemic therapy ± palliative surgery and (2) cytoreductive surgery with intraperitoneal chemotherapy (CRS+IPC). Due to scarce evidence, PM from SBA represents a therapeutic challenge. This narrative review summarized and discussed the evidence that investigated available treatment options. METHODS: Studies were discussed if they investigated first line systemic therapy for advanced SBA or CRS+IPC for PM from SBA...
December 5, 2016: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/27866427/image-guided-thermal-ablation-might-be-a-way-to-compensate-for-image-deriving-cancer-overdiagnosis-author-reply
#4
Ji-Hoon Kim, Jung Hwan Baek, Jin Yong Sung, Dong Gyu Na
No abstract text is available yet for this article.
December 1, 2016: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/27903081/percutaneous-microwave-ablation-of-renal-cell-carcinoma-is-safe-in-patients-with-renal-dysfunction
#5
Yan Lin, Ping Liang, Xiao-Ling Yu, Jie Yu, Zhi-Gang Cheng, Zhi-Yu Han, Fangyi Liu
OBJECTIVES: To present the clinical effect of microwave ablation(MWA) on renal cell carcinoma(RCC) of the patients with renal dysfunction, mainly focusing on the extent of renal tumor control and damage to the residual kidney function. METHODS AND MATERIALS: From 2006 to 2014, 19 tumors of 18 patients with renal dysfunction underwent percutaneous ultrasound-guided MWA in our institution. The tumor diameters range from 1.9 to 5.0cm. The serum creatinine and urea levels of each patient pre-MWA, 1 day after MWA and the most recent occasion on record at our institution were collected...
November 30, 2016: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/27866424/image-guided-thermal-ablation-might-be-a-way-to-compensate-for-image-deriving-cancer-overdiagnosis
#6
Giovanni Mauri, Luca Maria Sconfienza
No abstract text is available yet for this article.
November 30, 2016: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/27881031/cavitation-enhances-coagulated-size-during-pulsed-high-intensity-focussed-ultrasound-ablation-in-an-isolated-liver-perfusion-system
#7
Lu-Yan Zhao, Shan Liu, Zong-Gui Chen, Jian-Zhong Zou, Feng Wu
PURPOSE: To investigate whether cavitation enhances the degree of coagulation during pulsed high-intensity focussed ultrasound (HIFU) in an isolated liver perfusion system. METHODS: Isolated liver was treated by pulsed HIFU or continuous-wave HIFU with different portal vein flow rates. The cavitation emission during exposure was recorded, and real-time ultrasound images were used to observe changes in the grey scale. The coagulation size was measured and calculated...
November 24, 2016: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/27825273/is-ablation-appropriate-for-management-of-benign-thyroid-nodules
#8
Mesut Tez, Barıs Yıldız
No abstract text is available yet for this article.
November 22, 2016: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/27855557/201-consecutive-cytoreductive-surgery-crs-and-hyperthermic-intraperitoneal-chemotherapy-hipec-procedures-in-a-single-asian-tertiary-centre
#9
Grace Tan, Claramae Chia, Mrinal Kumar, Su Pin Choo, John Chia, Chee Kian Tham, Khee Chee Soo, Melissa Teo
INTRODUCTION: Peritoneal carcinomatosis (PC) is increasingly being treated with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). We provide a review of a high-volume Asian institute's experience and survival outcomes with this procedure. METHODS: Data was prospectively collected from 201 consecutive CRS and HIPEC procedures performed in a single institution between April 2001 and November 2015. Our primary endpoints were OS and DFS, and secondary endpoints were morbidity and mortality...
November 17, 2016: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/27405728/safety-and-advantages-of-combined-resection-and-microwave-ablation-in-patients-with-bilobar-hepatic-malignancies
#10
Prejesh Philips, C R Scoggins, J K Rostas, K M McMasters, R C Martin
BACKGROUND: The multimodality approach has significantly improved outcomes for hepatic malignancies. Microwave ablation is often used in isolation or succession, and seldom in combination with resection. Potential benefits and pitfalls from combined resection and ablation therapy in patients with complex and extensive bilobar hepatic disease have not been well defined. METHODS: A review of the University of Louisville prospective Hepato-Pancreatico-Biliary Patients database was performed with multi-focal bilobar disease that underwent microwave ablation with resection or microwave only included...
November 16, 2016: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/27701923/benign-thyroid-nodules-treatment-using-percutaneous-laser-ablation-pla-and-radiofrequency-ablation-rfa
#11
Giovanni Mauri, Luca Cova, Cristian Giuseppe Monaco, Luca Maria Sconfienza, Sabrina Corbetta, Stefano Benedini, Federico Ambrogi, Valentina Milani, Alberto Baroli, Tiziana Ierace, Luigi Solbiati
PURPOSE: To evaluate the reduction over time of benign thyroid nodules treated using percutaneous laser ablation (PLA) and radiofrequency ablation (RFA) by the same equipe. MATERIALS AND METHODS: Ninety patients (age 55.6 ± 14.1 years) underwent ablation for benign thyroid nodule causing compression/aesthetic dissatisfaction from 2011. Fifty-nine (age 55.8 ± 14.1 years) underwent RFA and 31 (age 55.2 ± 14.2 years) PLA, ultrasound guided. Technical success, complications, duration of ablation and treatment, energy deployed, volumetric percentage reduction at 1, 6 and 12 months were derived...
November 15, 2016: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/27829293/incorporating-detailed-biology-in-hyperthermia-treatment-planning-a-necessary-condition-for-progress
#12
Robert J Myerson
No abstract text is available yet for this article.
November 9, 2016: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/27829290/hsp90-inhibitors-in-the-context-of-heat-shock-and-the-unfolded-protein-response-effects-on-a-primary-canine-pulmonary-adenocarcinoma-cell-line
#13
Arin N Graner, Justin E Hellwinkel, Alex M Lencioni, Helen J Madsen, Tessa A Harland, Paul Marchando, Ger J Nguyen, Mary Wang, Laura M Russell, Lynne T Bemis, Thomas J Anchordoquy, Michael W Graner
BACKGROUND: Agents targeting HSP90 and GRP94 are seldom tested in stressed contexts such as heat shock (HS) or the unfolded protein response (UPR). Tumor stress often activates HSPs and the UPR as pro-survival mechanisms. This begs the question of stress effects on chemotherapeutic efficacy, particularly with drugs targeting chaperones such as HSP90 or GRP94. We tested the utility of several HSP90 inhibitors, including PU-H71 (targeting GRP94), on a primary canine lung cancer line under HS/UPR stress compared to control conditions...
November 9, 2016: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/27825274/percutaneous-ablation-holds-the-potential-to-substitute-for-surgery-as-first-choice-treatment-for-symptomatic-benign-thyroid-nodules
#14
Giovanni Mauri, Luca Maria Sconfienza
No abstract text is available yet for this article.
November 8, 2016: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/27809612/ultrasound-guided-microwave-ablation-a-promising-tool-in-management-of-benign-breast-tumors
#15
Wenbin Zhou, Ruoxi Wang, Xiaoan Liu, Lijun Ling, Mengdi Liang, Cuiying Li, Ge Ma, Li Li, Hong Pan, Haiyan Gong, Qiang Ding, Shui Wang
PURPOSE: Nonsurgical treatments for benign breast tumors have clinical goals of stopping growth and/or reducing (removing) palpable tumors effect without leaving a surgical scar. The purpose of this nonrandomized prospective clinical trial was to assess imaging and clinical outcomes of microwave ablation (MWA) in the treatment of benign breast tumors regardless of the distance from the tumor to the skin and chest wall. METHODS: With approval of the institutional ethics committee and written informed consent, 39 patients with 44 core-biopsy-proved benign breast tumors 3...
November 3, 2016: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/27790950/magnetic-resonance-texture-parameters-are-associated-with-ablation-efficiency-in-mr-guided-high-intensity-focussed-ultrasound-treatment-of-uterine-fibroids
#16
Arnaud Hocquelet, Baudouin Denis de Senneville, Nora Frulio, Cécile Salut, Mounir Bouzgarrou, Panteleimon Papadopoulos, Hervé Trillaud
OBJECTIVES: The objective of this study is to assess the association between texture parameter analysis derived from T2-weighted images and efficiency of magnetic resonance-guided focussed ultrasound (MRgFUS) ablation for the treatment of uterine fibroids. MATERIALS AND METHODS: Fifty-five women treated by MRgFUS were included in this retrospective analysis. Texture parameters were calculated using three 2D regions of interest placed on three consecutive slices on the same sagittal 3D T2-weighted images obtained at the beginning of MRgFUS ablation...
October 28, 2016: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/27776457/homologous-recombination-preferentially-repairs-heat-induced-dna-double-strand-breaks-in-mammalian-cells
#17
Akihisa Takahashi, Eiichiro Mori, Yosuke Nakagawa, Atsuhisa Kajihara, Tadaaki Kirita, L Pittman Douglas, Masatoshi Hasegawa, Takeo Ohnishi
PURPOSE: Heat shock induces DNA double-strand breaks (DSBs), but the precise mechanism of repairing heat-induced damage is unclear. Here, we investigated the DNA repair pathways involved in cell death induced by heat shock. MATERIALS AND METHODS: B02, a specific inhibitor of human RAD51 (homologous recombination; HR), and NU7026, a specific inhibitor of DNA-PK (non-homologous end-joining; NHEJ), were used for survival assays of human cancer cell lines with different p53-gene status...
October 24, 2016: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/27764970/combination-of-microbubbles-and-diagnostic-ultrasound-at-a-high-mechanical-index-for-the-synergistic-microwave-ablation-of-tumours
#18
Jinshun Xu, Yang Cao, Chunyan Xu, Xueqing Cheng, Yufeng You, Yuanzhi Yao, Jianxin Liu, Zhigang Wang, Pan Li, Min Lu
OBJECTIVES: To determine whether combining microbubbles (MBs) with diagnostic ultrasound (US) at a high mechanical index (MI) could enhance the microwave (MW) ablation of tumours. MATERIALS AND METHODS: Five therapeutic MW adjuvant protocols were studied: MW, MW + US, MW + US + MB, MW + US + NS (saline), and MW + MB. In 30 normal rabbit livers, the synergistic effects were evaluated via temperature, necrosis volume and histology. In 90 VX2 rabbit hepatic tumours, residual cells in the peripheral ablated tumours were examined via immunohistochemical assay and tumour growth...
October 20, 2016: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/27744728/3d-radiobiological-evaluation-of-combined-radiotherapy-and-hyperthermia-treatments
#19
C M van Leeuwen, J Crezee, A L Oei, N A P Franken, L J A Stalpers, A Bel, H P Kok
PURPOSE: Currently, clinical decisions regarding thermoradiotherapy treatments are based on clinical experience. Quantification of the radiosensitising effect of hyperthermia allows comparison of different treatment strategies, and can support clinical decision-making regarding the optimal treatment. The software presented here enables biological evaluation of thermoradiotherapy plans through calculation of equivalent 3D dose distributions. METHODS: Our in-house developed software (X-Term) uses an extended version of the linear-quadratic model to calculate equivalent radiation dose, i...
October 17, 2016: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/27724046/combination-therapy-of-three-dimensional-3d-visualization-operative-treatment-planning-system-and-us-guided-percutaneous-microwave-ablation-in-larger-renal-cell-carcinomas-d%C3%A2-4%C3%A2-cm-preliminary-results
#20
Xin Li, Jie Yu, Ping Liang, Xiaoling Yu, Chengzhi Gang, Hanzhi Yu, Hui Huang, Shaobo Duan, Jiasheng Zheng
Purpose To analyze the clinical outcomes of combination therapy of three-dimensional (3D) visualization operative treatment planning system and US-guided percutaneous microwave ablation (PMWA) in larger renal cell carcinomas (RCCs) (D≥4 cm). Materials and Methods The results from 20 patients with 20 larger RCCs treated with a 3D visualization operative treatment planning system and US-guided PMWA were reviewed retrospectively. The patients were followed up by contrast-enhanced images at 1, 3, and 6 months and every 6 months thereafter...
October 11, 2016: International Journal of Hyperthermia
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