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International Journal of Hyperthermia

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https://www.readbyqxmd.com/read/29214884/adjuvant-intraperitoneal-chemotherapy-for-the-treatment-of-colorectal-cancer-at-risk-for-peritoneal-carcinomatosis-a-systematic-review
#1
Paul L Feingold, Nicholas D Klemen, Mei Li M Kwong, Barry Hashimoto, Udo Rudloff
BACKGROUND: The peritoneal surface is the second most common site of disease recurrence, after the liver, following definitive surgery for colorectal cancer. Adjuvant intraperitoneal (IP) chemotherapy delivered at time of surgical resection has the potential to delay or prevent future spread to the peritoneal surface and improve clinical outcome. The exact role of adjuvant IP chemotherapy in colorectal cancer, including its associated morbidity and mortality, is not well defined. STUDY DESIGN: Systematic review and pooled random effect analysis of comparative trials examining the addition of adjuvant IP chemotherapy compared to surgery alone in colorectal cancer...
December 7, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/29202667/percutaneous-microwave-ablation-of-renal-cell-carcinoma-using-a-high-power-microwave-system-focus-upon-safety-and-efficacy
#2
D K Filippiadis, C Gkizas, M Chrysofos, A Siatelis, G Velonakis, E Alexopoulou, A Kelekis, E Brountzos, N Kelekis
OBJECTIVES: Percutaneous ablation is an expanding, minimally invasive approach for small- to medium-sized renal masses. The purpose of this study is to review safety, and mid-term efficacy of percutaneous microwave ablation (MWA) for Renal Cell Carcinoma (RCC) treatment using a high power microwave system. METHODS AND MATERIALS: Institutional database research identified 50 consecutive patients with a single lesion resembling renal cell carcinoma in CT and MRI who underwent percutaneous microwave ablation using a high power microwave system...
December 4, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/29191126/intravesical-radiofrequency-induced-hyperthermia-enhances-mitomycin-c-accumulation-in-tumour-tissue
#3
F Johannes P van Valenberg, Antoine G van der Heijden, Rianne J M Lammers, Johannes Falke, Tom J H Arends, Egbert Oosterwijk, J Alfred Witjes
INTRODUCTION: Non-muscle invasive bladder cancer (NMIBC) is a highly recurrent disease with potential progression to muscle invasive disease despite the standard bladder instillations with mitomycin C (MMC) or Bacille Calmette-Guérin immunotherapy. Therefore, alternatives such as radiofrequency-induced chemohyperthermia (RF-CHT) with MMC are being investigated. The mechanism explaining the efficacy of RF-CHT is only partly understood. We examined whether RF-CHT results in higher MMC tissue concentrations as compared to cold MMC instillation...
December 1, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/29168401/the-clinical-benefit-of-hyperthermia-in-pancreatic-cancer-a-systematic-review
#4
Astrid van der Horst, Eva Versteijne, Marc G H Besselink, Joost G Daams, Esther B Bulle, Maarten F Bijlsma, Johanna W Wilmink, Otto M van Delden, Jeanin E van Hooft, Nicolaas A P Franken, Hanneke W M van Laarhoven, Johannes Crezee, Geertjan van Tienhoven
OBJECTIVE: In pancreatic cancer, which is therapy resistant due to its hypoxic microenvironment, hyperthermia may enhance the effect of radio(chemo)therapy. The aim of this systematic review is to investigate the validity of the hypothesis that hyperthermia added to radiotherapy and/or chemotherapy improves treatment outcome for pancreatic cancer patients. METHODS AND MATERIALS: We searched MEDLINE and Embase, supplemented by handsearching, for clinical studies involving hyperthermia in pancreatic cancer patients...
November 23, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/29166797/application-of-dynamic-thermal-imaging-in-a-photocarcinogenesis-mouse-model
#5
Yoo Sang Baek, Jaeyoung Kim, Geo Han, Chil Hwan Oh
INTRODUCTION In clinical practice and experimental settings, cutaneous premalignant and malignant lesions are commonly diagnosed by histopathological biopsy. However, this technique is invasive and results in functional or cosmetic defects. Dynamic thermal imaging is a non-invasive technique that quantifies the infrared (IR) radiation emitted by a subject after the introduction of external thermal stimuli (such as heat or cold). METHODS Forty hairless albino (Crl:SKH1-hr) mice were randomized to the control group or the experimental group...
November 22, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/29161924/ultrasound-guided-percutaneous-microwave-ablation-vs-surgical-resection-for-thoracoabdominal-wall-implants-from-hepatocellular-carcinoma-intermediate-term-results
#6
Chao An, Zi-Long Hu, Ping Liang, Zhi-Gang Cheng, Zhi-Yu Han, Jie Yu, Fang-Yi Liu
OBJECTIVE: The aims of this study were to compare the clinical outcomes between ultrasound (US)-guided percutaneous microwave ablation (MWA) and surgical resection (SR) in patients with thoracoabdominal wall implants from hepatocellular carcinom (HCC) and to identify the prognostic factors associated with the two treatment methods. MATERIALS AND METHODS: A total of 47 patients (mean age, 56.7 ± 15.9 years, range, 18-78 years; 34 men and 13 women) with 61 thoracoabdominal wall HCC seeding were included from April 2007 to May 2017...
November 21, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/29157042/head-out-immersion-in-hot-water-increases-serum-bdnf-in-healthy-males
#7
Daisuke Kojima, Takeshi Nakamura, Motohiko Banno, Yasunori Umemoto, Tokio Kinoshita, Yuko Ishida, Fumihiro Tajima
PURPOSE: Brain-derived neurotrophic factor (BDNF) is an important neurotrophin. The present study investigated the effects of head-out water immersion (HOI) on serum BDNF concentrations. METHODS: Eight healthy men performed 20 min head-out water immersion at 42 °C (hot-HOI) and 35 °C (neutral-HOI). These experimental trials were administered in a randomised order separated by at least 7 days. Venous blood samples were withdrawn at rest, immediately after the 20-min HOI, as well as at 15 and 30 min after the end of the HOI...
November 20, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/29145750/feasibility-of-on-line-temperature-based-hyperthermia-treatment-planning-to-improve-tumour-temperatures-during-locoregional-hyperthermia
#8
H P Kok, L Korshuize-van Straten, A Bakker, R de Kroon-Oldenhof, G H Westerveld, E Versteijne, L J A Stalpers, J Crezee
BACKGROUND: The effectiveness of hyperthermia is strongly dependent on the achieved tumour temperatures. Phased-array systems allow flexible power steering to realise good tumour heating while avoiding excessive heating in normal tissue, but the limited quantitative accuracy of pre-treatment planning complicates realising optimal tumour heating. On-line hyperthermia treatment planning could help to improve the heating quality. This paper demonstrates the feasibility of using on-line temperature-based treatment planning to improve the heating quality during hyperthermia in three patients...
November 16, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/29108446/the-usefulness-of-mobile-insulator-sheets-for-the-optimization-of-deep-heating-area-for-regional-hyperthermia-using-a-capacitively-coupled-heating-method-phantom-simulation-and-clinical-prospective-studies
#9
Kyosuke Tomura, Takayuki Ohguri, Hendrik Thijmen Mulder, Motohiro Murakami, Sota Nakahara, Katsuya Yahara, Yukunori Korogi
PURPOSE: To evaluate the feasibility and efficacy of deep regional hyperthermia with the use of mobile insulator sheets in a capacitively-coupled heating device. MATERIALS AND METHODS: The heat was applied using an 8-MHz radiofrequency-capacitive device. The insulator sheet was inserted between the regular bolus and cooled overlay bolus in each of upper and lower side of the electrode. Several settings using the insulator sheets were investigated in an experimental study using an agar phantom to evaluate the temperature distributions...
November 6, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/29103320/cross-sectional-area-of-the-murine-aorta-linearly-increases-with-increasing-core-body-temperature
#10
A Colleen Crouch, Adam B Manders, Amos A Cao, Ulrich M Scheven, Joan M Greve
PURPOSE: The cardiovascular (CV) system plays a vital role in thermoregulation. To date, the response of core vasculature to increasing core temperature has not been adequately studied in vivo. Our objective was to non-invasively quantify the arterial response in murine models due to increases in body temperature, with a focus on core vessels of the torso and investigate whether responses were dependent on sex or age. METHODS: Male and female, adult and aged mice were anaesthetised and underwent magnetic resonance imaging (MRI)...
November 6, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/29096566/perivascular-extension-of-microwave-ablation-zone-demonstrated-using-an-ex-vivo-porcine-perfusion-liver-model
#11
Saurabh Singh, Pulathis Nilantha Siriwardana, Edward William Johnston, Jennifer Watkins, Steve Bandula, Rowland Illing, Brian Ritchie Davidson
Microwave ablation (MWA) has been proposed to suffer less from the heat sink effect compared to radiofrequency ablation but has been reported to cause extension of the ablation zone along intrahepatic vessels in clinical practice. To study this effect in detail, eight fresh porcine livers were perfused in an ex-vivo organ perfusion system. Livers were perfused with oxygenated, O-positive human blood at 37°C. Perfusion was discontinued immediately before ablation in the non-perfused group (n = 4) whilst in the perfused group (n = 4) perfusion was maintained during MWA (140W X 2min)...
November 2, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/29082799/the-efficacy-and-safety-of-microwave-ablation-in-patients-with-retroperitoneal-metastases
#12
Zhigang Wei, Xin Ye, Xia Yang, Aimin Zheng, Guanghui Huang, Shenming Dong, Wenhong Li, Jiao Wang, Xiaoying Han, Min Meng, Yang Ni
BACKGROUND: Retroperitoneal metastases are common, and most present with symptoms; however, treatments for this condition are limited. This retrospective study verified the efficacy and safety of microwave ablation (MWA) in retroperitoneal metastases patients. METHODS: Patients with pathologically confirmed malignant carcinoma and imaging showing retroperitoneal metastases were enrolled and underwent MWA. The end-points included objective response rate, time to local progression (TTLP), overall survival, visual analogue scale (VAS) score, dose of morphine pre- and post-ablation and complications...
October 30, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/29082796/thermal-ablation-of-hepatocellular-carcinoma-in-patients-with-abnormal-coagulation-function
#13
Qiannan Huang, Erjiao Xu, Lei Tan, Qingjing Zeng, Rongqin Zheng, Kai Li
OBJECTIVE: To evaluate the safety of thermal ablation for hepatocellular carcinoma (HCC) in patients with abnormal coagulation function. METHODS: Fifty-seven HCC tumours in 50 patients were treated with thermal ablation. All patients had a meted platelet count <50 × 10(9)/L or international normalised ratio (INR) ≥ 1.7. Gastroscopy before ablation, platelet concentrate or fresh frozen plasma transfusion during ablation and contrast enhanced ultrasoundgraphy (CEUS)-guided ablation to cease needle tract bleeding were performed to reduce haemorrhage...
October 30, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28978237/exploring-the-trend-in-referrals-for-consideration-of-crs-and-hipec-to-understand-the-attitudes-of-clinicians-in-the-development-of-a-national-cancer-centre-programme-in-peritoneal-disease
#14
Weining Wang, Grace Hwei Ching Tan, Thakshayeni Skanthakumar, Claramae Shulyn Chia, Khee Chee Soo, Melissa Ching Ching Teo
INTRODUCTION: Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) improve survival in selected patients with peritoneal metastases. However, only some patients who are potentially eligible for the procedure are considered and referred to the appropriate surgical department. By studying the trends of patients being considered for CRS and HIPEC in our centre, we hope to better understand the demographics of our patient cohort and the attitudes of physicians involved towards CRS and HIPEC...
October 30, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/29063825/target-visualisation-and-microwave-hyperthermia-monitoring-using-nanoparticle-enhanced-transmission-ultrasound-netus
#15
Or Perlman, Iris S Weitz, Haim Azhari
PURPOSE: The aim of this study was to examine the feasibility of using nanoparticle-enhanced transmission ultrasound (NETUS) as an image-based monitoring modality for microwave hyperthermia treatment. METHODS: A dedicated transmission ultrasound imaging system was used to obtain acoustic projections and ultrasound computed tomography images. Initially, speed-of-sound based images were used to non-invasively monitor temperature changes in in vitro and ex vivo specimens, induced by a microwave needle-type applicator...
October 24, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/29063804/the-pre-operative-neutrophil-lymphocyte-ratio-predicts-overall-and-disease-free-survival-following-cytoreductive-surgery-crs-and-hyperthermic-intraperitoneal-chemotherapy-hipec-in-patients-with-pseudomxyoma-peritonei-of-appendiceal-origin
#16
Karan Rangarajan, Kandiah Chandrakumaran, Sanjeev Dayal, Faheez Mohamed, Brendan J Moran, Thomas D Cecil
AIM: The neutrophil-lymphocyte ratio (NLR) and other inflammation-based scores have been used as a prognostic tool to predict survival in solid tumours including pseudomyxoma peritonei (PMP). The aim was to evaluate the prognostic value of this marker and risk stratify PMP patients undergoing cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). METHODS: Retrospective analysis was conducted of a prospectively collected database of patients with PMP who underwent CRS and HIPEC between 1994 and 2015...
October 24, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28982246/application-of-microwave-ablation-in-the-emergent-control-of-intraoperative-life-threatening-tumor-hemorrhage-during-hepatic-surgeries
#17
Haoming Zhou, Jindao Wu, Wei Ling, Deming Zhu, Ling Lu, Xuehao Wang, Liyong Pu, Lianbao Kong
PURPOSE: This study was designed to evaluate the efficacy and safety of microwave ablation (MWA) in the treatment of intraoperative life-threatening tumour haemorrhage during hepatic surgeries. METHODS: Three cases of MWA application in the emergent control of life-threatening hepatic tumour haemorrhage were analysed and reported. RESULTS: Satisfactory hemostasis for hepatic tumour rupture was achieved by MWA in all three cases. No major complications, such as post-operative haemorrhage, bile duct injury, liver abscess, colon perforation, skin burns, tumour seeding or renal dysfunction, were identified...
October 23, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28974122/activation-of-hypoxia-inducible-factor-1%C3%AE-in-rat-brain-after-perinatal-anoxia-role-of-body-temperature
#18
Hanna Kletkiewicz, Malwina Hyjek, Krzysztof Jaworski, Anna Nowakowska, Justyna Rogalska
Transcriptional hypoxia-inducible factor-1α (HIF-1α) plays the fundamental role in adaptive processes in response to hypoxia. Specific HIF-1α target genes are involved in glycolysis, erythropoiesis and angiogenesis to promote survival. In our previous study we have demonstrated that naturally low body temperature of newborn rats protects them against damage due to perinatal hypoxia. Therefore, our experiments aimed at checking the effects of body temperature during simulated perinatal anoxia on subsequent changes of expression of HIF-1α and its specific target genes such as vascular endothelial growth factor (VEGF) and erythropoietin (EPO) in the rat brain...
October 23, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/29046072/commentary-on-the-clinical-and-preclinical-dosage-limits-of-interstitially-administered-magnetic-fluids-for-therapeutic-hyperthermia-based-on-current-practice-and-efficacy-models
#19
Paul Southern, Quentin A Pankhurst
We offer a critique of what constitutes a suitable dosage limit, in both clinical and preclinical studies, for interstitially administered magnetic nanoparticles in order to enable therapeutic hyperthermia under the action of an externally applied alternating magnetic field. We approach this first from the perspective of the currently approved clinical dosages of magnetic nanoparticles in the fields of MRI contrast enhancement, sentinel node detection, iron replacement therapy and magnetic thermoablation. We compare this to a simple analytical model of the achievable hyperthermia temperature rise in both humans and animals based on the interstitially administered dose, the heating and dispersion characteristics of the injected fluid, and the strength and frequency of the applied magnetic field...
October 18, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28931333/hyperthermia-treatment-planning-guided-applicator-selection-for-sub-superficial-head-and-neck-tumors-heating
#20
Tomas Drizdal, Margarethus M Paulides, Netteke van Holthe, Gerard C van Rhoon
PURPOSE: In this study, we investigated the differences in hyperthermia treatment (HT) quality between treatments applied with different hyperthermia systems for sub-superficial tumours in the head and neck (H&N) region. MATERIALS AND METHODS: In 24 patients, with a clinical target volume (CTV) extending up to 6 cm from the surface, we retrospectively analysed the predicted HT quality achievable by two planar applicator arrays or one phased-array hyperthermia system...
October 16, 2017: International Journal of Hyperthermia
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