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Diabetes Research and Clinical Practice

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https://www.readbyqxmd.com/read/28081450/heparanase-driven-inflammation-from-the-ages-stimulated-macrophages-changes-the-functions-of-glomerular-endothelial-cells
#1
Guang Xu, Qiaojing Qin, Min Yang, Zhongdong Qiao, Yong Gu, Jianying Niu
AIMS: Amounts of macrophages were infiltrated in glomeruli in diabetic nephropathy. Heparanase has been thought to be closely related to proteinuria. Our aims were to determine the effect of heparanase on the inflammation in AGEs-stimulated macrophages and its role on the functions of glomerular endothelial cells (GEnCs). METHODS: The expression of inflammation cytokines in macrophages were assayed by q-RT PCR, western, and ELISA. Then western was used to measure the expression of RAGE and key proteins in NF-κB pathway in macrophages...
December 30, 2016: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28086201/the-effects-of-glp-1-based-therapies-on-postprandial-haemodynamics-two-randomised-placebo-controlled-trials-in-overweight-type-2-diabetes-patients
#2
Mark M Smits, Lennart Tonneijck, Marcel H A Muskiet, Trynke Hoekstra, Mark H H Kramer, Michaela Diamant, Daniël H van Raalte
AIMS: To assess the effects of glucagon-like peptide (GLP)-1 receptor agonists and dipeptidyl peptidase (DPP)-4 inhibitors on postprandial haemodynamics. METHODS: 57 patients with type 2 diabetes (mean±SD age 62.8±6.9years; BMI 31.8±4.1kg/m(2); HbA1c 7.3±0.6%) were included in an acute (exenatide- or placebo-infusion) and 12-week (liraglutide, sitagliptin or placebo) randomised, placebo-controlled, double-blind trial. Systemic haemodynamics (oscillometric technique and finger photoplethysmography), vascular stiffness (tonometry), and sympathetic nervous system (SNS)-activity (heart rate variability) were determined in the fasting state and following a standardised mixed meal...
December 27, 2016: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28081449/diabetes-diagnostic-thresholds-of-the-glycated-hemoglobin-a1c-and-fasting-plasma-glucose-levels-considering-the-5-year-incidence-of-retinopathy
#3
Tomoko Nakagami, Kanako Takahashi, Chikako Suto, Junko Oya, Yuki Tanaka, Moritoshi Kurita, Chisato Isago, Yukiko Hasegawa, Arata Ito, Yasuko Uchigata
AIMS: As retinopathy is used as a defining threshold of diabetes, we assessed the glycated hemoglobin A1c (HbA1c) and fasting plasma glucose (FPG) values associated with an increased risk of 5-year incidence of retinopathy. METHODS: We studied HbA1c, FPG, and optic fundus findings of 2605 individuals without previously diagnosed diabetes annually during a 5-year period. Retinopathy was examined using non-mydriatic, 45° digital fundus photography. Baseline levels were stratified as <5...
December 27, 2016: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28081448/the-relationships-among-fear-of-hypoglycaemia-diabetes-related-quality-of-life-and-psychological-well-being-in-norwegian-adults-with-type-1-diabetes
#4
Ragnhild B Strandberg, Marit Graue, Tore Wentzel-Larsen, Mark Peyrot, Astrid K Wahl, Berit Rokne
AIMS: To examine the associations among fear of hypoglycaemia, diabetes-related quality of life and psychological well-being, and determine whether diabetes-related quality of life is a mediator of the relationship between fear of hypoglycaemia and psychological well-being in adults with Type 1 diabetes. METHODS: A total of 235 of 319 invited adults (18-69years) with Type 1 diabetes agreed to participate. Hierarchical linear regression was applied to 188 individuals with complete data...
December 27, 2016: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28056430/the-effects-of-sitagliptin-a-dpp-4-inhibitor-on-cognitive-functions-in-elderly-diabetic-patients-with-or-without-alzheimer-s-disease
#5
Ahmet Turan Isik, Pinar Soysal, Adnan Yay, Cansu Usarel
AIMS: The present study aimed to evaluate effect of sitagliptin, a dipeptidyl peptidase-4 inhibitor (DPP-4I), on cognitive functions in elderly diabetic patients with and without cognitive impairment. METHODS: 253 elderly patients with type 2DM, were enrolled in this prospective and observational study. After comprehensive geriatric assessment, the patients were divided into either sitagliptin or non-sitagliptin group. RESULTS: A total of 205 patients who completed the study (52 with Alzheimer's Disease (AD)) were re-evaluated 6months later...
December 21, 2016: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28056431/second-line-initiation-of-insulin-compared-with-dpp-4-inhibitors-after-metformin-monotherapy-is-associated-with-increased-risk-of-all-cause-mortality-cardiovascular-events-and-severe-hypoglycemia
#6
Thomas Nyström, Johan Bodegard, David Nathanson, Marcus Thuresson, Anna Norhammar, Jan W Eriksson
AIMS: The objective of this nationwide study was to compare the risk of all-cause mortality, fatal and nonfatal cardiovascular disease (CVD), and severe hypoglycemia in patients with type 2 diabetes (T2D) on metformin monotherapy treatment starting second-line treatment with either insulin or dipeptidyl peptidase-4 inhibitor (DPP-4i). METHODS: All patients with T2D in Sweden who initiated second-line treatment with insulin or DPP-4i after metformin monotherapy during 2007-2014 identified in the Swedish Prescribed Drug Register were followed for outcome in the Cause of Death and National Patient Registers...
December 19, 2016: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28062174/diabetic-retinopathy-is-not-present-in-non-diabetic-older-overweight-obese-african-americans
#7
LETTER
Mayer B Davidson
No abstract text is available yet for this article.
December 18, 2016: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28062173/high-altitude-is-not-a-risk-factor-for-type-2-diabetes-mellitus
#8
LETTER
Walter Calderón-Gerstein
No abstract text is available yet for this article.
December 18, 2016: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28057324/possible-survivorship-bias-rather-than-reverse-causality-in-empa-reg-outcome
#9
LETTER
André J Scheen
No abstract text is available yet for this article.
December 18, 2016: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28062172/reverse-causality-in-empa-reg-outcome-the-proverbial-elephant
#10
LETTER
Rajesh Rajput, Jignesh Ved
No abstract text is available yet for this article.
December 10, 2016: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28061430/exploring-the-characteristics-of-suboptimally-controlled-patients-after-24weeks-of-basal-insulin-treatment-an-individualized-approach-to-intensification
#11
Kamlesh Khunti, Taner Damci, Lise Lotte Husemoen, Vinay Babu, Andreas Liebl
AIM: To identify characteristics of suboptimally controlled patients with type 2 diabetes (T2DM) on basal insulin treatment who may benefit from intensive titration or further intensification of treatment. METHODS: A post hoc analysis of SOLVE: a 24-week, international, observational study conducted in 17,374 patients with T2DM inadequately controlled on oral antidiabetic drugs (OADs) started on once-daily insulin detemir. Patients were divided into two groups based on whether they achieved HbA1c<7...
December 9, 2016: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28088030/efficacy-and-safety-of-linagliptin-metformin-single-pill-combination-as-initial-therapy-in-drug-na%C3%A3-ve-asian-patients-with-type-2-diabetes
#12
Yiming Mu, Changyu Pan, Bei Fan, Uwe Hehnke, Xiuzhen Zhang, Xuejun Zhang, Xiaoyue Wang, Jingdong Liu, Ying Zhang, Jianling Du, Jianhua Ma, Yan Gong
AIM: To assess efficacy/safety of initial linagliptin/metformin single-pill combination (SPC) therapies versus individual drug components over 24weeks in treatment-naïve Asian patients with type 2 diabetes mellitus and insufficient glycemic control. METHODS: Patients (initial glycated hemoglobin [HbA1c] ⩾7.5% to <11.0% [58-97mmol/mol]; main group) were randomized to: linagliptin 5mg once daily (qd); metformin 500mg twice daily (bid); metformin 1000mg bid; linagliptin 2...
December 5, 2016: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28056429/weight-change-after-initiation-of-oral-hypoglycemic-monotherapy-for-diabetes-predicts-5-year-mortality-an-observational-study
#13
Beverly M Kocarnik, Kathryn P Moore, Nicholas L Smith, Edward J Boyko
PURPOSE: To investigate whether weight change in the first year after initiating an oral hypoglycemic agent (OHA) for type 2 diabetes treatment is associated with mortality in a national cohort. PROCEDURES: We prospectively followed Veterans Health Administration patients with type 2 diabetes initiating treatment with an OHA and not receiving any other diabetes pharmacotherapy for at least one year. Information on OHAs, weight, co-morbidities, other medications, demographics, and laboratory measurements was obtained from electronic medical records...
December 5, 2016: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28011411/call-to-action-a-new-path-for-improving-diabetes-care-for-indigenous-peoples-a-global-review
#14
REVIEW
Stewart B Harris, Jordan W Tompkins, Braden TeHiwi
Diabetes has reached epidemic proportions in Indigenous populations around the globe, and there is an urgent need to improve the health and health equity of Indigenous peoples with diabetes through timely and appropriate diabetes prevention and management strategies. This review describes the evolution of the diabetes epidemic in Indigenous populations and associated risk factors, highlighting gestational diabetes and intergenerational risk, lifestyle risk factors and social determinants as having particular importance and impact on Indigenous peoples...
December 5, 2016: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28006698/type-2-diabetes-mellitus-in-african-women
#15
REVIEW
Julia H Goedecke, Asanda Mtintsilana, Siphiwe N Dlamini, Andre Pascal Kengne
Compared to global estimates, Sub-Saharan Africa (SSA) has the highest projected rates of increase in type 2 diabetes (T2D) over the next 25years. This is attributed to the ageing population, increasing urbanisation and the associated lifestyle changes. Although the prevalence does not differ by gender, deaths attributable to T2D in SSA are greater in women, likely due to differences in beliefs and access to care. Women in SSA also have greater risk factor burden for T2D than men, in particular obesity, which is explained in part by sociocultural factors...
December 5, 2016: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28006697/diabetes-mellitus-and-cardiovascular-clinical-characteristics-of-spanish-women-with-stable-ischaemic-heart-disease-data-from-the-sirena-study
#16
José M Gámez, Luis Masmiquel, Tomás Ripoll, Vivencio Barrios, Manuel Anguita
The relationship between diabetes and the cardiovascular clinical characteristics of Spanish women with stable ischaemic heart disease was studied in a nationwide cross-sectional study. Diabetes was related to a higher burden of risk factors, comorbidity, multivessel disease and coronary surgery.
December 5, 2016: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28003048/response-to-the-letter-by-tomoyuki-kawada-regarding-the-article-entitled-association-between-hypoglycemia-and-dementia-in-patients-with-type-2-diabetes
#17
LETTER
Yi-Jing Sheen, Wayne H H Sheu
No abstract text is available yet for this article.
December 5, 2016: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28002752/coronary-atherosclerosis-burden-by-coronary-computed-tomography-in-type-ii-diabetes-with-preclinical-non-obstructive-carotid-atherosclerosis-and-without-inducible-myocardial-ischemia
#18
Vittorio Palmieri, Enzo Gravino, Cesare Russo, Armenio Salvati, Carmelo Lombardi, Rosario Sauro, Giuseppe Rosato
AIMS: To quantify cardiovascular risk in persons with type-2 diabetes (DM) and established carotid atherosclerosis, without inducible myocardial ischemia by stress imaging. METHODS: We selected clinically healthy DM and subjects without DM (nonDM, controls) with non-obstructive carotid atherosclerosis and without significant coronary artery disease (CAD) by stress echocardiography. Coronary flow velocity reserve (CFR) was assessed during stress echocardiography...
December 5, 2016: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28002751/validity-of-hospital-discharge-records-to-identify-pregestational-diabetes-in-an-italian-population
#19
Lucia Borsari, Carlotta Malagoli, Paola Ballotari, Gianfranco De Girolamo, Karin Bonora, Federica Violi, Oreste Capelli, Rossella Rodolfi, Fausto Nicolini, Marco Vinceti
AIMS: In recent years, the prevalence of pregestational diabetes (PGDM) and the concern about the possibility of adverse pregnancy outcomes in affected women have been increasing. Routinely collected health data represent a timely and cost-efficient approach in PGDM epidemiological research. This study aims to evaluate the reliability of hospital discharge (HD) coding to identify a population-based cohort of pregnant women with PGDM and to assess trends in prevalence in two provinces of Northern Italy...
December 5, 2016: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/27997862/the-association-of-pulse-pressure-with-metabolic-syndrome-in-korean-elderly-a-nationwide-population-based-study
#20
Yu-Jin Kwon, Tae-Ha Chung, Jae-Yong Shim, Yong-Jae Lee
AIMS: Metabolic syndrome (MetS) is one of the most important issues in elderly people because of its association with ensuing cardiovascular disease (CVD). The components of MetS play a key role in the pathogenesis of arterial thickness and stiffness. Pulse pressure (PP), an easily accessible parameter in a basic health evaluation, has been documented as a marker of arterial stiffness and widespread atherosclerosis. The aim of our study was to assess the association between PP and MetS in Korean elderly people...
December 5, 2016: Diabetes Research and Clinical Practice
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