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Diabetes Research and Clinical Practice

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https://www.readbyqxmd.com/read/28284168/effects-of-postmeal-exercise-on-postprandial-glucose-excursions-in-people-with-type-2-diabetes-treated-with-add-on-hypoglycemic-agents
#1
Melissa L Erickson, Jonathan P Little, Jennifer L Gay, Kevin K McCully, Nathan T Jenkins
AIMS: Type 2 diabetes treatment primarily focuses on reducing hyperglycemia, including postprandial glucose excursions. Hypoglycemic agents are used clinically to lower fasting and postprandial glucose. Metformin is the first-line therapy; however, if metformin is inadequate then 'add-on' hypoglycemic agents are implemented. Postmeal exercise has been shown to lower postprandial glucose. The aim of this study was to assess if postmeal exercise provides additional glucose-lowering benefit, beyond medication alone, in those on add-on hypoglycemic agents...
March 8, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28319804/are-diabetes-guidelines-truly-evidence-based
#2
REVIEW
Matthew F Bouchonville, Sara Matani, Jason J DuBroff, Robert J DuBroff
The global epidemic of obesity and diabetes underscores the urgency to develop strategies to prevent cardiovascular (CV) disease in this vulnerable population. Clinical guidelines are intended to help the clinician manage these patients, but guidelines are often discordant among professional organizations and not always evidence based. Clinicians must rely upon the best available evidence, and therefore we critically reviewed the evidence behind the American Diabetes Association (ADA) 2016 guidelines on the prevention of CV disease in diabetes...
March 7, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28319803/social-economic-costs-of-type-1-diabetes-mellitus-in-pediatric-patients-in-spain-chrystal-observational-study
#3
Julio López-Bastida, Juan Pedro López-Siguero, Juan Oliva-Moreno, Magaly Perez-Nieves, Renata Villoro, Tatiana Dilla, María Merino, Dingfeng Jiang, Isaac Aranda-Reneo, Jesús Reviriego, Luis Alberto Vázquez
AIMS: To estimate the social-economic costs of Type 1 Diabetes Mellitus (T1DM) in patients aged 0-17years in Spain from a social perspective. METHODS: We conducted a cross-sectional observational study in 2014 of 275 T1DM pediatric outpatients distributed across 12 public health centers in Spain. Data on demographic and clinical characteristics, healthcare utilization and informal care were collected from medical records and questionnaires completed by clinicians and patients' caregivers...
March 7, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28319802/associations-between-home-insulin-dose-adjustments-and-glycemic-outcomes-at-hospital-admission
#4
Saira Khan, Sherita Hill Golden, Nestoras Mathioudakis
AIMS: To describe patterns of home insulin dose adjustments for non-surgical, non-critically ill patients at admission and to describe associations between these adjustments and inpatient glycemic control. METHODS: Hospital records of non-critically ill patients treated with basal insulin prior to admission were identified. After exclusion of records in which a confounding factor influencing insulin dosing was present, 258 patient-admissions over a 3-year time period were included...
March 7, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28319801/first-trimester-prediction-of-gestational-diabetes-mellitus-a-clinical-model-based-on-maternal-demographic-parameters
#5
Arianne N Sweeting, Heidi Appelblom, Glynis P Ross, Jencia Wong, Heikki Kouru, Paul F Williams, Mikko Sairanen, Jon A Hyett
AIM: Develop a first trimester risk prediction model for GDM based on maternal clinical characteristics in a large metropolitan multi-ethnic population and compare its performance to that of other recently published GDM prediction models and clinical risk scoring systems. METHODS: A retrospective case control study of 248 women who developed GDM and 732 controls who did not. Maternal clinical parameters were prospectively obtained at 11-13(+6) weeks' gestation. A predictive multivariate regression model for GDM was developed, evaluated using areas under the receiver-operating characteristic (AUC) curve...
March 7, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28292654/vinegar-consumption-can-attenuate-postprandial-glucose-and-insulin-responses-a-systematic-review-and-meta-analysis-of-clinical-trials
#6
REVIEW
Farideh Shishehbor, Anahita Mansoori, Fatemeh Shirani
OBJECTIVE: Postprandial hyperglycemia plays a decisive role in the development of chronic metabolic disorders. The effect of vinegar intake with a meal on postprandial glucose has been studied in several trials with conflicting results. RESEARCH METHODS AND PROCEDURES: The purpose of the current study was to systematically review control trials that report on the effect of vinegar intake on postprandial glucose response. Postprandial insulin response was considered as secondary outcome...
March 2, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28288434/uk-lipohypertrophy-interventional-study
#7
Mike Smith, Linda Clapham, Kenneth Strauss
INTRODUCTION: Lipohypertrophy (LH) is one of the most common complications of insulin therapy. We conducted a prospective study in 18 UK centres to assess the impact of a targeted LH intervention on a range of clinical, biological and socio-economic parameters. METHODS: Seventy-five insulin-injecting patients were recruited randomly and were followed prospectively for 3-6months, with results compared to baseline values. Interventions included the use of an intensive education program and a switch to a 4mm pen needle...
March 2, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28324867/blood-glucose-levels-and-glycaemic-burden-in-76-341-patients-attending-primary-care-bittersweet-findings-from-a-9-year-cohort-study
#8
Melinda J Carrington, Neale Cohen, Joshua F Wiley
AIMS: Diabetes care is principally applied in the primary care setting whereby we examined trends in glycaemic levels and goals and estimated avoidable glycaemic burden. METHODS: We retrieved glycated haemoglobin (HbA1C) results and glucose-lowering prescription records from a patient-based medical database during 2005-2013. There were 275,480 available HbA1C measurements from 76,341 individuals managed by 960 general practitioners from 321 clinics across Australia...
February 27, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28319805/depressive-states-among-adults-with-diabetes-findings-from-the-national-health-and-nutrition-examination-survey-2007-2012
#9
Juan Rafael Albertorio-Diaz, Mark S Eberhardt, Maria Oquendo, Marco Mesa-Frias, Yulei He, Bruce Jonas, Kai Kang
AIMS: To determine (1) the prevalence of SubD states among adults with diabetes, and (2) whether evidence exists of an independent association between diabetes status and SubD, controlling for selected confounders. METHODS: Data from the 2007-2012 National Health and Nutrition Examination Surveys were combined to estimates of depressive states by diabetes status among the noninstitutionalized U.S. adult population, and to assess the association of diabetes status and depressive states using a polytomous logistic regression model...
February 27, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28315576/control-of-lower-extremity-edema-in-patients-with-diabetes-double-blind-randomized-controlled-trial-assessing-the-efficacy-of-mild-compression-diabetic-socks
#10
Stephanie C Wu, Ryan T Crews, Melissa Skratsky, Julia Overstreet, Sai V Yalla, Michelle Winder, Jacquelyn Ortiz, Charles A Andersen
AIMS: Persons with diabetes frequently present with lower extremity (LE) edema; however, compression therapy is generally avoided for fear of compromising arterial circulation in a population with a high prevalence of peripheral arterial disease. This double blind randomized controlled trial (RCT) assessed whether diabetic socks with mild compression could reduce LE edema in patients with diabetes without negatively impacting vascularity. METHODS: Eighty subjects with LE edema and diabetes were randomized to receive either mild-compression knee high diabetic socks (18-25mmHg) or non-compression knee high diabetic socks...
February 27, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28315574/consensus-statement-on-insulin-therapy-in-chronic-kidney-disease
#11
REVIEW
Rajesh Rajput, Binayak Sinha, Sujoy Majumdar, M Shunmugavelu, Sarita Bajaj
INTRODUCTION: Diabetes mellitus (DM) is one of the leading causes of chronic kidney disease (CKD) which eventually leads to insulin resistance and decreased insulin degradation. In patients with diabetic kidney disease (DKD), the overall insulin requirement declines which necessitates the reassessment for individualization, adjustment and titration of insulin doses depending on the severity of kidney disease. OBJECTIVE: To provide simple and easily implementable guidelines to primary care physicians on appropriate insulin dosing and titration of various insulin regimens in patients with DKD...
February 27, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28288436/cell-therapy-of-critical-limb-ischemia-in-diabetic-patients-state-of-art
#12
REVIEW
Michal Dubský, Alexandra Jirkovská, Robert Bem, Andrea Nemcová, Vladimira Fejfarová, Edward B Jude
In this review we report on the state of cell therapy of critical limb ischemia (CLI) with respect to differences between diabetic and non-diabetic patients mainly from the clinical point of view. CLI is the most severe form of peripheral arterial disease and its diagnosis and treatment in diabetic patients is very difficult. The therapeutic effect of standard methods of CLI treatment is only partial - more than one third of diabetic patients are not eligible for standard revascularization; therefore, new therapeutic techniques such as cell therapy have been studied in clinical trials...
February 27, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28288435/comparing-a-telephone-and-a-group-delivered-diabetes-prevention-program-characteristics-of-engaged-and-non-engaged-postpartum-mothers-with-a-history-of-gestational-diabetes
#13
Siew Lim, James A Dunbar, Vincent L Versace, Edward Janus, Carol Wildey, Timothy Skinner, Sharleen O'Reilly
AIMS: To explore the acceptability of a telephone- or a group-delivered diabetes prevention program for women with previous gestational diabetes and to compare the characteristics associated with program engagement. METHODS: Postpartum women participated in a lifestyle modification program delivered by telephone (n=33) or group format (n=284). Semi-structured interviews on barriers and enablers to program engagement (defined as completing≥80% sessions) were conducted before (Group) and after (Group and Telephone) interventions...
February 27, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28256277/corrigendum-to-severe-fatigue-in-type-1-diabetes-exploring-its-course-predictors-and-relationship-with-hba1c-in-a-prospective-study-diabetes-res-clin-pract-121-2016-127-134
#14
Juliane Menting, Stephanie Nikolaus, William M van der Veld, Martine M Goedendorp, Cees J Tack, Hans Knoop
No abstract text is available yet for this article.
February 27, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28273645/biomarkers-of-stress-mediated-metabolic-deregulation-in-diabetes-mellitus
#15
REVIEW
Dina R Johar, Larry H Bernstein
This review illustrates the relationship of oxidative and nitrative stress to diabetes mellitus and its complications. This is of considerable interest because diabetes mellitus is a lifetime systemic metabolic disease that may have childhood or adult onset and affects not only a triad of pancreatic islet cell insulin, pituitary insulin-like growth hormone, and liver steatosis, it has a long-term association with adiposity, atherosclerosis, coronary vascular disease, kidney disease of the nature afferent arteriolar sclerosis and nodular glomerulosclerosis, cerebrovascular disease, and amyloid deposition in the pancreas and kidney...
February 24, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28315575/systematic-review-on-the-cost-effectiveness-of-self-management-education-programme-for-type-2-diabetes-mellitus
#16
REVIEW
J X Lian, S M McGhee, J Chau, Carlos K H Wong, Cindy L K Lam, William C W Wong
OBJECTIVES: A review of cost-effectiveness studies on self-management education programmes for Type 2 diabetes mellitus. METHODS: Cochrane, PubMed and PsycINFO databases were searched for papers published from January 2003 through September 2015. Further hand searching using the reference lists of included papers was carried out. RESULTS: In total, 777 papers were identified and 12 papers were finally included. We found eight programmes whose effectiveness analyses were based on randomised controlled trials and whose costs were comprehensively estimated from the stated perspective...
February 22, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28273644/practices-perceptions-and-expectations-for-carbohydrate-counting-in-patients-with-type-1-diabetes-results-from-an-online-survey
#17
Andréanne Fortin, Rémi Rabasa-Lhoret, Amélie Roy-Fleming, Katherine Desjardins, Anne-Sophie Brazeau, Martin Ladouceur, Véronique Gingras
AIMS: Characterize adult patients with diabetes on intensive insulin therapy in terms of: (a) practices and perceived difficulties relative to carbohydrate counting (CC) and diabetes treatment, and (b) their perceptions and expectations relative to CC. METHODS: Participants completed a 30-question web-based questionnaire. RESULTS: Participants with type 1 diabetes (T1D) and using CC as part of their treatment plan (n=180) were included in this analysis...
February 22, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28288437/podiatry-impact-on-high-low-amputation-ratio-characteristics-a-16-year-retrospective-study
#18
Brian M Schmidt, James S Wrobel, Michael Munson, Gary Rothenberg, Crystal M Holmes
PURPOSE: Complications from diabetes mellitus including major lower extremity amputation may have significant impact on a patient's mortality. This study determined what impact the addition of a limb salvage and diabetic foot program involving podiatry had at an academic institution over 16years by analyzing high-low amputation ratio data. METHODS: The high-low amputation ratio in the diabetic population who underwent non-traumatic amputation of the lower extremity was retrospectively evaluated at an academic institution via cohort discovery of the electronic medical record and analysis of billing over 16years...
February 21, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28284167/albiglutide-for-the-treatment-of-type-2-diabetes-mellitus-an-integrated-safety-analysis-of-the-harmony-phase-3-trials
#19
Bo Ahrén, Molly C Carr, Karen Murphy, Christopher Perkins, Marc Rendell, Jason Mallory, Timothy Wilson, Susan Johnson
AIMS: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) stimulate the incretin system and lower glycaemic parameters in type 2 diabetes mellitus (T2DM). This analysis of clinical studies of up to 3years evaluated the safety of albiglutide, a GLP-1 RA, in people with T2DM. METHODS: Integrated safety analysis included seven phase-3 T2DM studies of albiglutide compared with placebo and/or active comparators (a dipeptidyl peptidase-4 inhibitor, GLP-1 RA, insulin, sulphonylurea, and thiazolidinedione)...
February 20, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28258027/impact-of-an-educational-dvd-on-anxiety-and-glycaemic-control-in-women-diagnosed-with-gestational-diabetes-mellitus-gdm-a-randomised-controlled-trial
#20
Claire R Draffin, Fiona A Alderdice, David R McCance, Michael Maresh, Roy Harper, Christopher C Patterson, Giovanna Bernatavicius, Sarah F Brennan, Aisling Gough, Oonagh McSorley, Valerie A Holmes
AIMS: The diagnosis of gestational diabetes mellitus (GDM) during pregnancy can lead to anxiety. This study evaluated the impact of an innovative patient-centred educational DVD on anxiety and glycaemic control in women newly diagnosed with GDM. METHODS: 150 multi-ethnic women, aged 19-44years, from three UK hospitals were randomised to either usual care plus DVD (DVD group, n=77) or usual care alone (control group, n=73) at GDM diagnosis. Primary outcomes were anxiety (State-Trait Anxiety Inventory) and mean 1-h postprandial capillary self-monitored blood glucose for all meals, on day prior to follow-up...
February 20, 2017: Diabetes Research and Clinical Practice
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