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Diabetes Research and Clinical Practice

Julia H Goedecke, Cindy George, Katherine Veras, Nasheeta Peer, Carl Lombard, Hendriena Victor, Krisela Steyn, Naomi S Levitt
AIMS: Black Africans are disproportionally affected by type 2 diabetes, but the pathophysiology is poorly understood. The study aimed to examine the effect of sex and age on insulin sensitivity and insulin response in black South African adults. METHODS: This cross-sectional study included a random sample of 179 men and 260 women aged 25-74years with normal glucose tolerance from 5 peri-urban townships in Cape Town, SA. Insulin sensitivity (insulin sensitivity index, ISI0,120) and response (insulinogenic index, IGI), and the disposition index (DI, ISI0,120×IGI), derived from an oral glucose tolerance test, were measured...
November 17, 2016: Diabetes Research and Clinical Practice
S R Whitworth, D G Bruce, S E Starkstein, W A Davis, T M E Davis, R S Bucks
AIMS: To determine the contribution of lifetime major depressive disorder (L-MDD) and lifetime generalized anxiety disorder (L-GAD) to current psychological symptom severity, health behaviour and glycaemic control in type 2 diabetes. METHODS: 1285 community-dwelling people with type 2 diabetes (Fremantle Diabetes Study Phase-II; FDS2) completed the PHQ-9 and Brief Life-Time Depression Scale (BLDS) to assess current and past MDD. The Generalized Anxiety Disorder Scale (GADS) and the Generalized Anxiety Disorder Scale-Lifetime (GAD-LT), designed for FDS2, assessed current and past anxiety...
November 9, 2016: Diabetes Research and Clinical Practice
Alice Courties, Jérémie Sellam
Osteoarthritis (OA) is the most frequent joint disorder and one of the leading cause of disability. During a long time, it was considered as the consequence of aging and mechanical stress on cartilage. Recent advances in the knowledge of OA have highlighted that it is a whole joint disease with early modifications of synovium and subchondral bone but also that it is associated with obesity and metabolic syndrome through systemic mechanisms. In the past year, type 2 diabetes has been described in two meta-analyzes as an independent risk factor for OA...
November 5, 2016: Diabetes Research and Clinical Practice
Tomoyuki Kawada
No abstract text is available yet for this article.
November 5, 2016: Diabetes Research and Clinical Practice
Paresh Chaudhari, Carlos Vallarino, Ernest H Law, Raafat Seifeldin
AIM: This study evaluates the association of pretreatment with oral antidiabetics (OADs) on clinical outcomes and health resource utilization among commercially insured type II diabetes mellitus (T2DM) patients in the United States. METHODS: Using administrative data (Truven MarketScan® Research Databases), patients diagnosed with T2DM between 2007 and 2014 with ⩾6months continuous enrolment pre- and post-diagnosis were evaluated. Pretreatment was defined as OAD use at least 3months prior to T2DM diagnosis...
November 3, 2016: Diabetes Research and Clinical Practice
Pei Lin Hu, Yi Ling Eileen Koh, Ngiap Chuan Tan
BACKGROUND: The prevalence of type 2 diabetes mellitus is rising, with many Asian countries featured in the top 10 countries with the highest numbers of persons with diabetes. Reliable diabetes risk scores enable the identification of individuals at risk of developing diabetes for early intervention. OBJECTIVES: This article aims to identify common risk factors in the risk scores with the highest discrimination; factors with the most influence on the risk score in Asian populations, and to propose a set of factors translatable to the multi-ethnic Singapore population...
November 2, 2016: Diabetes Research and Clinical Practice
Ken-Ichiro Tanaka, Ippei Kanazawa, Toshitsugu Sugimoto
BACKGROUND: Several studies showed that sarcopenia and visceral obesity are associated with arterial stiffness. Thus, their coexistence may be a crucial risk factor of arteriosclerosis. However, little is known about the cross relationships among muscle mass, visceral fat mass, and arterial stiffness in type 2 diabetes mellitus (T2DM). METHODS: We recruited 97 postmenopausal women with T2DM and examine the association of muscle mass and visceral fat mass with brachial-ankle pulse wave velocity (baPWV)...
November 2, 2016: Diabetes Research and Clinical Practice
Itty Sethi, G R Bhat, Vinod Singh, Rakesh Kumar, A J S Bhanwer, Rameshwar N K Bamezai, Swarkar Sharma, Ekta Rai
Type 2 Diabetes Mellitus (T2DM), a multifactorial complex disorder, is emerging as a major cause of morbidity, mortality and socio-economic burden across the world. Despite huge efforts in understanding genetics of T2DM, only ∼10% of the genetic factors have been identified so far. Telomere attrition, a natural phenomenon has recently emerged in understanding the pathophysiology of T2DM. It has been indicated that Telomeres and associated pathways might be the critical components in the disease etiology, though the mechanism(s) involved are not clear...
October 21, 2016: Diabetes Research and Clinical Practice
Takahiro Yajima, Kumiko Yajima, Makoto Hayashi, Hiroshi Takahashi, Keigo Yasuda
AIMS: Appropriate glycemic control without hypoglycemia is important in patients with type 2 diabetes on hemodialysis. Teneligliptin, a novel dipeptidyl peptidase-4 inhibitor, can be used without dose adjustment for these patients. Using continuous glucose monitoring (CGM), we evaluated the efficacy and safety of adding teneligliptin to insulin therapy. METHODS: Twenty-one type 2 diabetes mellitus patients on hemodialysis treated with insulin were enrolled. After the adjustment of insulin dose, their blood glucose level was monitored by CGM...
October 21, 2016: Diabetes Research and Clinical Practice
Kathryn Fisher, Lauren Griffith, Andrea Gruneir, Dilzayn Panjwani, Sima Gandhi, Li Lisa Sheng, Amiram Gafni, Patterson Chris, Maureen Markle-Reid, Jenny Ploeg
AIMS: This study describes the comorbid conditions in Canadian, community-dwelling older adults with diabetes and the association between the number of comorbidities and health service use and costs. METHODS: This retrospective cohort study used multiple linked administrative data to determine 5-year health service utilization in a population-based cohort of community-living individuals aged 66 and over with a diabetes diagnosis as of April 1, 2008 (baseline). Utilization included physician visits, emergency department visits, hospitalizations, and home care services...
October 20, 2016: Diabetes Research and Clinical Practice
Ying Chen, Yunqing Zhi, Chengqian Li, Ying Liu, Lifang Zhang, Yangang Wang, Kui Che
A meta-analysis was conducted to assess the impact of HDL on risk of diabetic nephropathy in T1DM patients. Ten papers containing (7698) participants were included in this meta-analysis. Our meta-analysis suggest that the risk of diabetic nephropathy was decreased with HDL in type 1 diabetes.
October 20, 2016: Diabetes Research and Clinical Practice
Zaw Wai Htoo, Wei-Wen Hsu, Richard Rosenkranz
This systematic review with meta-analysis examined whether lifestyle modification (diet and/or exercise) is effective for glycemic control in adults with type 2 diabetes in Southeast Asia. Results showed that lifestyle modification is effective in the short term (3months), but not over the longer term (6months) in this population.
October 19, 2016: Diabetes Research and Clinical Practice
M Sørensen, F Arneberg, T M Line, T J Berg
AIMS: To quantify the excess cost of diabetes in Norway in 2011. METHODS: A national cross-sectional cost-of-illness analysis of direct and indirect diabetes-related healthcare costs, based on pseudonymised data from six public national registers, international studies, and clinical expertise. Direct medical costs are estimated from primary and secondary health care registers and the national prescription database. Indirect costs include social and productivity costs...
October 19, 2016: Diabetes Research and Clinical Practice
S Carter, P M Clifton, J B Keogh
AIMS: Weight loss improves glycaemic control in type 2 diabetes mellitus (T2DM). However, as achieving and maintaining weight loss is difficult, alternative strategies are needed. Our primary aim was to investigate the effects of intermittent energy restriction (IER) compared to continuous energy restriction (CER) on glycated haemoglobin A1c (HbA1c). Secondary aims were to assess effects on weight loss, body composition, medication changes and subjective measures of appetite. Using a 2-day IER method, we expected equal improvements to HbA1c and weight in both groups...
October 19, 2016: Diabetes Research and Clinical Practice
Blake Fensom, Claire Harris, Sharon E Thompson, Mohammed Al Mehthel, David M Thompson
BACKGROUND: Neuropathy is a common diabetic complication that can result in significant disability. Few treatment options exist to reverse this process. METHODS: We conducted a one-way crossover cohort study comparing intensive medical treatment and islet cell transplantation for type 1 diabetes on the change in nerve conduction velocity over six years. FINDINGS: For subjects with some neuropathy at baseline (Z score below -1), nerve conduction velocity significantly improved post-transplant (slope (0...
October 19, 2016: Diabetes Research and Clinical Practice
Nianhong Wang, Junqing Zhang, Yiming Wu, Jia Liu, Lin Liu, Xiaohui Guo
OBJECTIVE: This study aimed to investigate the role of MTP on lipid metabolism disorders in insulin-resistant rats and the potential mechanism through which metformin can improve lipid metabolism disorders. METHODS: 30 OLETF rats served as research subjects and 18 LETO rats of the same strain served as the control group (LETO group). After the first oral glucose tolerance test (at 8-week-old), 6 rats were randomly killed from each group. The remaining 24 OLETF rats were randomly divided into untreated group (OLETF group) and treated group (OLETF/M group, cured with metformin)...
October 15, 2016: Diabetes Research and Clinical Practice
Soo Heon Kwak, Chan-Hyeon Jung, Chang Ho Ahn, Jungsun Park, Jeesoo Chae, Hye Seung Jung, Young Min Cho, Dae Ho Lee, Jong-Il Kim, Kyong Soo Park
AIMS: There could be an overlap of monogenic diabetes and early onset type 2 diabetes in those who are diagnosed before age of 30years. Genetic diagnosis in these patients might improve the quality of care. A limited number of studies have used whole exome sequencing (WES) in Asian patients with early onset diabetes, and the clinical utility of WES is largely unknown. METHODS: We performed whole exome capture and massive parallel sequencing in 28 patients with early onset diabetes...
October 15, 2016: Diabetes Research and Clinical Practice
Makoto Ohara, Tomoyasu Fukui, Motoshi Ouchi, Kentaro Watanabe, Tatsuya Suzuki, Saki Yamamoto, Takeshi Yamamoto, Toshiyuki Hayashi, Kenzo Oba, Tsutomu Hirano
AIMS: To determine the association of daily and day-to-day glucose variability with oxidative stress. METHODS: This was a cross-sectional analysis of 68 patients with type 2 diabetes mellitus (T2DM) over 72h of continuous glucose monitoring. Fasting plasma glucose (FPG) and hemoglobin A1c (HbA1c) were measured before breakfast on day 1. Glucose variability, mean glucose level (MGL), mean amplitude of glycemic excursions (MAGE), mean of daily differences (MODD) in glucose levels and area under the postprandial plasma glucose curve (AUCPP) were measured on days 2 and 3...
October 14, 2016: Diabetes Research and Clinical Practice
Javier Escalada, Domingo Orozco-Beltran, Carlos Morillas, Fernando Alvarez-Guisasola, Fernando Gomez-Peralta, Manel Mata-Cases, Rafael Palomares, Rosario Iglesias, Concepción Carratalá-Munuera
AIMS: To describe the views of healthcare providers about starting insulin in patients with type 2 diabetes and to determine the specific factors that contribute to delay insulin initiation. METHODS: Two-phases observational descriptive study. In the quantitative phase we conducted a cross-sectional survey of a sample of 380 healthcare professionals (general practitioners (GPs), endocrinologists, internists and nurses). In the qualitative phase, a discussion group reviewed the results of the survey to propose solutions...
October 14, 2016: Diabetes Research and Clinical Practice
Munehide Matsuhisa, Masayoshi Koyama, Xi Cheng, Mariko Sumi, Matthew C Riddle, Geremia B Bolli, Takahisa Hirose
AIMS: To evaluate the efficacy and safety of insulin glargine 300U/mL (Gla-300) versus glargine 100U/mL (Gla-100) in adults with type 1 diabetes in Japan over 12months. METHODS: EDITION JP 1 was a multicentre, randomised, open-label phase 3 study. Following a 6-month on-treatment period, participants continued to receive Gla-300 or Gla-100 once daily, plus mealtime insulin, over a 6-month open-label extension phase. HbA1c, hypoglycaemia, body weight and adverse events were assessed...
October 13, 2016: Diabetes Research and Clinical Practice
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