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Diabetes Research and Clinical Practice

Dorothy J Van Buren, Denise E Wilfley, Marsha D Marcus, Barbara Anderson, Natalie Walders Abramson, Robert Berkowitz, Carolyn Ievers-Landis, Paula Trief, Patrice Yasuda, Kathryn Hirst
The relationship between depressive symptoms and glycemic control in youth with type 2 diabetes was assessed at baseline (n=682), 6, and/or 24 months (n=576). Neither baseline nor persistence of depressive symptoms was significantly associated with maintenance of glycemic control. Nevertheless, depressive symptoms were common, suggesting the importance of repeated screening.
November 13, 2017: Diabetes Research and Clinical Practice
Mayer B Davidson, Deyu Pan
AIM: We performed a meta-analysis of epidemiological studies evaluating exposure to pioglitazone and the risk for bladder cancer and compared these results to the drug's effects on cardiovascular disease (CVD) and non-alcoholic steatohepatitis (NASH). METHODS: Pubmed and Embase were searched for cohort and case control studies for all years through 2016. RESULTS: Data from 17 papers were analyzed. In cohort studies, 822 of 357,888 pioglitazone-exposed patients (0...
November 13, 2017: Diabetes Research and Clinical Practice
Yang T Du, Palash Kar, Yasmine Ali Abdelhamid, Michael Horowitz, Adam M Deane
It remains uncertain if stress hyperglycaemia (SH) indicates a long-term predisposition to the development of type 2 diabetes. We conducted a retrospective observational study in critically ill patients and found SH to be associated with an increased HbA1c, which may indicate an increased risk of type 2 diabetes.
November 10, 2017: Diabetes Research and Clinical Practice
Heather Graz, Vijay K D Souza, David E C Alderson, Michael Graz
AIMS: The main aim of this study was to assess the cost of diabetic amputation (both direct and indirect) to the National Health Service from the point of amputation onwards. METHODS: This systematic review involved searches of published literature between January 2007 and March 2017 mainly using the bibliographic databases, the Cochrane Library, EMBASE via Ovid(®), MEDLINE via Ovid(®), as well as grey literature, both in print and in electronic formats published through non-commercial publications, which reported the cost of amputation due to diabetic foot ulcers RESULTS: The studies included in this review varied considerably in estimating the cost including cost elements and how those costs were categorised...
November 10, 2017: Diabetes Research and Clinical Practice
Paddy C Dempsey, David W Dunstan, Robyn N Larsen, Gavin W Lambert, Bronwyn A Kingwell, Neville Owen
Fatigue is a prevalent, costly and disabling clinical complaint among those with type 2 diabetes. In a randomized crossover trial, prolonged uninterrupted sitting increased fatigue by 29% relative to days when sitting was regularly interrupted by brief activity-breaks. This may have implications for diabetes-related quality of life, occupational productivity and self-care.
November 9, 2017: Diabetes Research and Clinical Practice
Ketan K Dhatariya, Edwin Li Ping Wah-Pun Sin, Joyce Oi Suet Cheng, Francesca Yan Nok Li, Anson Wei Yue Yue, Catherine Gooday, Ian Nunney
AIMS: Glycaemic variability - the visit-to-visit variation in HbA1c - plays a possible role in the development of micro and macrovascular disease in patients with diabetes. Whether HbA1c variability is a factor determining wound healing in diabetic foot ulcers remains unknown. We aimed to determine whether HbA1c variability is associated with foot ulcer healing time. METHODS: A retrospective analysis of patients presenting to our specialist multidisciplinary foot clinic between July 2013 and March 2015, with at least three HbA1c measurements within five years of presentation and more than two follow-up reviews...
October 31, 2017: Diabetes Research and Clinical Practice
Ju Hee Lee, Yea Eun Kang, Ji Min Kim, Sorim Choung, Kyong Hye Joung, Hyun Jin Kim, Bon Jeong Ku
We analyzed circulating Meteorin-like (METRNL) levels in human. Serum METRNL levels were significantly lower in subjects with diabetes mellitus compared with those without diabetes. Serum METRNL was negatively correlated with the serum glucose level and insulin resistance. Metformin treatment did not increase the serum METRL levels after 12 weeks.
October 31, 2017: Diabetes Research and Clinical Practice
Ronnie Aronson, Ruth E Brown, Dishay Jiandani, Ashleigh Walker, Naomi Orzech, Lawrence Mbuagbaw
AIMS: The LMC Skills, Confidence & Preparedness Index (SCPI) is an electronic tool designed to meet ISOQOL standards and (a) assess three dimensions: knowledge, confidence and preparedness; (b) provide a clinically meaningful measure; (c) provide immediate feedback to the healthcare provider. Internal consistency and external validity have been previously reported in a refractory diabetes cohort. This larger evaluation, broader in glycemic control, sought to assess clinical relevance to glycemia...
October 30, 2017: Diabetes Research and Clinical Practice
Carlo Bruno Giorda, Gabriele Forlani, Roberta Manti, Arianna Mazzotti, Salvatore De Cosmo, Maria Chiara Rossi, Antonio Nicolucci, Paolo Di Bartolo, Antonio Ceriello, Pietro Guida, Barbara Tartaglino, Giuseppina Russo
AIMS: The prevalence and progression of hepatic fibrosis and its correlated factors in type 2 diabetes (T2DM) are poorly known. We aimed to define the percentage of T2DM patients who progress to fibrosis and the factors associated with disease progression. METHODS: Data from the electronic health records of 1527 patients with diagnosed T2DM and nonalcoholic fatty liver disease (NAFLD), as diagnosed by the Fatty Liver Index, were extracted from the AMD Annals database, which collects data from the Italian network of diabetes clinics...
October 30, 2017: Diabetes Research and Clinical Practice
Trisha Dunning, Peter Martin
Palliative and end of life care are essential, but largely overlooked, aspects of comprehensive, personalised diabetes care. Life expectancy is lower in people with diabetes than in the general population due to complications and comorbidities, especially those associated with obesity such as cardiovascular disease, frailty and cancer. This paper makes the case for early initiation of palliative care and proactive planning for end of life. Early use of palliative care improves symptom management, comfort and quality of life, and often improves function...
October 30, 2017: Diabetes Research and Clinical Practice
Jing Li, Yingying Luo, Xiaohui Guo, Xiaoxu Huo, Juming Lu, Yanfeng Ren, Linong Ji, Xilin Yang
AIMS: To investigate the risk of Chinese females versus males for non-fatal coronary heart disease (CHD) due to long exposure to type 2 diabetes mellitus (T2DM). METHODS: 223,612 Chinese patients with T2DM were recruited from China in 2012. Binary logistic regression analysis was performed to obtain odds ratios (OR) of females versus males for non-fatal CHD. Additive interaction was used to test whether female gender and long exposure to T2DM (≥15 years) had a synergistic effect for non-fatal CHD...
October 29, 2017: Diabetes Research and Clinical Practice
Yukako Tatsumi, Akiko Morimoto, Kei Asayama, Nao Sonoda, Naomi Miyamatsu, Yuko Ohno, Yoshihiro Miyamoto, Satoshi Izawa, Takayoshi Ohkubo
AIMS: To investigate the effect of alcohol consumption on impaired insulin secretion and insulin resistance in Japanese. METHODS: The participants in this 5-year cohort study were 2100 Japanese aged 30-74 years without type 2 diabetes mellitus, impaired insulin secretion, or insulin resistance who underwent a medical checkup including 75-g OGTT between April 2008 and March 2009 at Saku Central Hospital. Alcohol consumption was categorized as follows: non-drinker (0 g/week), light drinker (1-139 g/week in men and 1-69 g/week in women), moderate drinker (140-274 g/week in men and 70-139 g/week in women) and heavy drinker (≥275 g/week in men and ≥140 g/week in women)...
October 28, 2017: Diabetes Research and Clinical Practice
Ling Chen, Bin Wei, Liang Xu, Yun Wu
OBJECTIVES: The present study was designed to investigate the association of four inflammatory markers and five periodontal indexes with the risk of coronary heart disease (CHD) in 131 patients with type 2 diabetes mellitus (T2DM). METHODS: All subjects were inpatients, including 63 T2DM patients with comorbid CHD ("cases") and 68 T2DM patients without CHD ("controls"). The diagnosis of CHD is based on coronary angiography. RESULTS: Peripheral blood concentrations of high sensitivity C-reactive protein (hs-CRP) (11...
October 28, 2017: Diabetes Research and Clinical Practice
Dean T Williams, Anna Powell-Chandler, Quratulain Qureshi, Aeliya Zaidi, Christopher J Whitaker
AIMS: The establishment of a vascular surgeon-led emergency diabetic foot service in 2006 has evolved to provide lower limb wound care for patients with and without diabetes. We aimed to determine whether the service was associated with sustained, improved limb salvage rates for the whole population, analyse key aspects of service provision and compare outcomes against published studies. METHODS: The vascular unit serves a largely rural population of approximately 240,000...
October 28, 2017: Diabetes Research and Clinical Practice
Erica Carine Campos Caldas Rosa, Renan Renato Cruz Dos Santos, Luis Fernando Amarante Fernandes, Francisco de Assis Rocha Neves, Michella Soares Coelho, Angelica Amorim Amato
AIMS: We investigated leukocyte relative telomere length (TL) in patients with type 2 diabetes (T2D) diagnosed for no longer than five years and its association with clinical and biochemical variables. METHODS: Peripheral blood leukocyte relative TL was investigated in 108 patients with T2D (87 women, 21 men) and 125 (37 women, 88 men) age-matched control subjects with normal glucose tolerance, by quantitative polymerase chain reaction. Multiple linear regression analysis was used to examine the association between relative TL and demographic, anthropometric and biochemical indicators of metabolic control among patients with T2D...
October 28, 2017: Diabetes Research and Clinical Practice
Yael Lebenthal, Naama Fisch Shvalb, Yael Gozlan, Ariel Tenenbaum, Yardena Tenenbaum-Rakover, Emmanuel Vaillant, Phillipe Froguel, Martine Vaxillaire, Galia Gat-Yablonski
Phenotypic variability in maturity-onset diabetes of the young (MODY) makes screening criteria for genomic analysis challenging. We describe the clinical spectrum in a large pedigree with HNF1A-MODY; as generations progressed, the course and outcome became poorer. Although uncommon, pancreatic autoantibodies and diabetes ketoacidosis should not exclude the diagnosis of MODY.
October 28, 2017: Diabetes Research and Clinical Practice
Matthew Tyler Boden, Sasha Gala
AIMS: To explore relations between diabetes-related stress and multiple sociodemographic, diabetes health, other health, and treatment-related variables among a large, diverse sample of adults with Type 1 Diabetes (T1D). METHODS: The sample consisted of 10,821 adults (over 18 years old) enrolled in the T1D Exchange Clinic Registry. The T1D Exchange clinic network consists of 67 diabetes clinical centers throughout the United States selected to broadly represent pediatric and adult patients with T1D...
October 28, 2017: Diabetes Research and Clinical Practice
Zhengyi Zhang, Huadong Liu, Jiankang Liu
Insulin resistance is a hallmark of type 2 diabetes and obesity while the mechanism remains unclear. Current therapy to treat type 2 diabetes is metformin, the 5'-monophosphate-activated protein kinase (AMPK) activator, owing to the ability to augment peripheral glucose uptake. However, metformin also displays limitations, as AMPK activation remains intact and regular in most type 2 diabetes and metformin does not seem to facilitate peripheral insulin resistance. Evidence has shown that PI3K-Akt/PKB pathway could be induced via insulin and act as an important effector...
October 27, 2017: Diabetes Research and Clinical Practice
Manhal Izzy, Mindy Lee, Krysta Johns-Keating, Faraj Kargoli, Steven Beckoff, Kwang Chun, Aaron Tokayer
AIM: To investigate the association between glycemic control represented by glycated hemoglobin (HbA1c) level and the value of 4-h gastric retention on nuclear scan. METHODS: We retrospectively reviewed records of diabetic patients who had 4-h nuclear gastric emptying study, with documented 4-h retention value, between January 1st, 2002 and July 30th, 2014 and had HbA1C level close to the time of the study. We divided our cohort into patients with good glycemic control (HbA1C <7, group A), fair control (7-9, group B), and poor control (>9, group C)...
October 27, 2017: Diabetes Research and Clinical Practice
Julia E von Oettingen, Erinn T Rhodes, Joseph I Wolfsdorf
AIMS: Data are sparse concerning use of serum electrolyte parameters as compared to venous blood gas (VBG) measurements to monitor acid-base status during treatment of diabetic ketoacidosis (DKA). We explored the utility of various parameters to define DKA resolution by investigating the relationship of venous pH (vpH), anion gap (AG), serum bicarbonate (HCO3), and glucose concentration during management of DKA in children with new onset diabetes mellitus (NODM). METHODS: We included all patients with NODM presenting with DKA to Boston Children's Hospital from 10/1/07-7/1/13...
October 27, 2017: Diabetes Research and Clinical Practice
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