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Diabetes Research and Clinical Practice

Juan José Gagliardino, Jean-Marc Chantelot, Catherine Domenger, Ambady Ramachandran, Ghaida Kaddaha, Jean Claude Mbanya, Marina Shestakova, Juliana Chan
AIMS: Self-management (self-monitoring of blood glucose, plus self-adjustment of insulin dose) is important in diabetes care, but its complexity presents a barrier to wider implementation, which hinders attainment and maintenance of glycemic targets. More evidence on self-management is needed to increase its implementation and improve metabolic outcomes. METHODS: Data from 1316 participants with type 1 diabetes mellitus who were enrolled from Middle East countries into the International Diabetes Management Practices Study (IDMPS), a multinational observational survey, were analyzed to assess the impact of education on disease management and outcomes...
September 12, 2018: Diabetes Research and Clinical Practice
Xue-Lian Zhang, Han-Jing Fu, Guang-Ran Yang, Gang Wan, Dongmei Li, Liang-Xiang Zhu, Rong-Rong Xie, Yu-Jie Lv, Jian-Dong Zhang, Yu-Ling Li, Qin-Fang Dai, Yu Ji, Da-Yong Gao, Xue-Li Cui, De-Yuan Liu, Shen-Yuan Yuan, Ming-Xia Yuan
OBJECTIVE: We investigated the prognostic significance of metabolic risk scores and aspirin with respect to cerebrovascular events. METHODS: A total of 25 communities of diabetic patients were enrolled in Beijing Community Diabetes Study (BCDS) from 2008. 3413 patients with T2DM in BCDS have complete screening data, including blood glucose, blood pressure, lipid profiles and anti-platelet therapy, which were assigned metabolic score (MS) and add up to the total metabolic score (TMS)...
September 12, 2018: Diabetes Research and Clinical Practice
Gunduz Ahmad Ahmadov, Denira Govender, Mark Alvin Atkinson, Rumiyya Anvar Sultanova, Amalia Abdulla Eubova, Clive Henry Wasserfall, Steven John Mack, Julie Ann Lane, Janelle Annette Noble, Graham David Ogle
AIMS: Determine the incidence and typology of diabetes in children in Azerbaijan. METHODS: Clinical features, C-peptide, autoantibodies (glutamic acid decarboxylase 65 (GAD65) and islet antigen 2 (IA-2)), and HLA-DRB1 status were studied in 106 subjects <18 years of age who were recently diagnosed. 104 cases were consecutive. Incidence was determined for Baku and Absheron regions, where ascertainment is estimated to be essentially 100%. RESULTS: 104 of the 106 (98%) were diagnosed with type 1 diabetes, one with type 2 diabetes and one with atypical diabetes...
September 12, 2018: Diabetes Research and Clinical Practice
Saibal Das, Sapan Kumar Behera, Akila Srinivasan, Alphienes Stanley Xavier, Sandhiya Selvarajan, Sadishkumar Kamalanathan, Jaya Prakash Sahoo, N Sreekumaran Nair
AIMS: To evaluate the effect of metformin on various parameters of exercise capacity [oxygen consumption (VO2 ), peak oxygen consumption (VO2peak ), heart rate (HR), exercise test duration, respiratory exchange ratio (RER), rating of perceived exertion (RPE), lactate and ventilatory anaerobic threshold (VAT)]. METHODS: Studies reporting change in VO2 or VO2peak after metformin administration were included. Subgroup analyses were performed as applicable. Mean difference with 95% CIs were pooled using random-effects model [RevMan (v5...
September 11, 2018: Diabetes Research and Clinical Practice
Fu-Liang Zhang, Ying-Qi Xing, Zhen-Ni Guo, Yan-Hua Wu, Hao-Yuan Liu, Yi Yang
AIMS: To explore the current prevalence and risk factors for diabetes and impaired fasting glucose in Northeast China. METHODS: This study adopted the multistage stratified random cluster sampling method to obtain a representative sample of adults aged 40 years or older in Dehui City, Jilin Province, Northeast China. Diabetes and impaired fasting glucose were defined according to the 1999 World Health Organization criteria. RESULTS: A total of 4,052 participants were included, with prevalence of diabetes in Northeast China of 11...
September 11, 2018: Diabetes Research and Clinical Practice
Caroline Tan, Alice M L Yong, Mohamad Azmi Haji Mohamad, Hanif Abdul Rahman, Lin Naing
AIM: To investigate the fasting pattern of patients with Diabetes Mellitus in Brunei Darussalam, specifically, their fasting activities, and knowledge and practice in relation to diabetes control during fasting in Ramadan. METHODS: Cross-sectional study that included 18 years and older, Muslim patients with diabetes mellitus who attended the main Diabetes Centre in Brunei. A self-administered questionnaire was designed, tested and used to collect the demographic information, fasting duration, knowledge and practice on diabetes control during fasting, and reasons of fasting as a Muslim...
September 10, 2018: Diabetes Research and Clinical Practice
Makoto Murata, Hitoshi Adachi, Taishuke Nakade, Shigeru Oshima
AIMS: We investigated the glucagon levels in patients with heart failure (HF), using long oral glucose tolerance test (OGTT). METHODS: In this prospective observational study, we enrolled 30 undiagnosed diabetes patients (age 69±10 years, 70% males, HbA1c 43 mmol/mol). A 4-h OGTT was performed. Glucose, insulin, and glucagon (radioimmunoassay [RIA] and sandwich ELISA [S-W] methods) were evaluated during 4-h. We compared glucagon levels between HF and non-HF patients...
September 10, 2018: Diabetes Research and Clinical Practice
Junko Oya, Marit Eika Jørgensen, Henrik Lund Andersen, Bendix Carstensen, Gregers Stig Andersen
AIMS: To examine the incidence rates of any and referable diabetic retinopathy (DR) in Denmark among migrants. METHODS: Nationwide clinical data on diabetes patients followed since 2005. Patients were classified according to country of origin into six groups: Denmark, other Europe, Sub Saharan Africa, Middle East/-North Africa, Asia, and America. 93,780 or 110,897 patients without any (include unspecific diagnoses) or referable (proliferative) DR at baseline were analyzed...
September 10, 2018: Diabetes Research and Clinical Practice
Hanaa Abokaf, Ilana Shoham-Vardi, Ruslan Sergienko, Daniella Landau, Eyal Sheiner
BACKGROUND: Gestational diabetes mellitus (GDM) is a worldwide public health problem. Few studies investigated the association of intra uterine exposure to GDM and long-term endocrine morbidity of offspring. OBJECTIVE: To assess whether in utero exposure to GDM increases the risk for long-term endocrine morbidity of the offspring. METHODS: A retrospective cohort study was conducted including all singleton born to women who delivered between 1988 and 2014...
September 10, 2018: Diabetes Research and Clinical Practice
Bernhard Kulzer, Wilfried Daenschel, Ingrid Daenschel, Wendelin Schramm, Diethelm Messinger, Joerg Weissmann, Iris Vesper, Christopher G Parkin, Lutz Heinemann
AIMS: Globally, many patients with insulin-treated type-2 diabetes are suboptimally controlled. The PDM-ProValue study program evaluated whether integrated personalized diabetes management (iPDM) has the potential to improve clinical outcomes. METHODS: 101 practices with 907 patients participated in the 12-month, prospective, controlled, cluster-randomized study program. HbA1c levels, therapy changes, frequency of hypoglycemic episodes, patient reported outcomes, and physician satisfaction were assessed...
September 8, 2018: Diabetes Research and Clinical Practice
Jinnan Liu, Enqing Liu, Junhong Leng, Lei Pan, Cuiping Zhang, Weiqin Li, Jing Li, Xiaoxu Huo, Juliana Cn Chan, Zhijie Yu, Gang Hu, Xilin Yang
AIMS: To examine associations between socio-economic status (SES) and gestational diabetes mellitus (GDM). METHODS: From 2010 to 2012, 17 659 women underwent glucose challenge test and oral glucose tolerance test if GCT ≥7.8 mmol/L at 24-28 gestational weeks in 6 urban districts of Tianjin, China. Binary logistic regression was used to obtain adjusted odds ratio (OR) of SES for GDM, as defined by education attainment and family monthly income. RESULTS: A total of 1264 women (or 7...
September 8, 2018: Diabetes Research and Clinical Practice
Claudia Caissutti, Vincenzo Berghella
BACKGROUND: Gestational diabetes (GDM) affects up to 7-18% of pregnant women and is associated with several maternal and perinatal morbidities. International organizations suggest several different recommendations regarding how to screen and to manage hyperglycemia in pregnancy (HIP). OBJECTIVE: We aimed to analyze the most important and employed guidelines about screening and management of HIP and we investigated existing related literature. RESULTS: We found several different criteria for screening for HIP, with the main difference being between non-USA-based IADPSG (One-step) approach, and the USA-based (Two-step) approach...
September 7, 2018: Diabetes Research and Clinical Practice
Gordon Sloan, Pallai Shillo, Dinesh Selvarajah, Jing Wu, Iain D Wilkinson, Irene Tracey, Praveen Anand, Solomon Tesfaye
The prevalence of diabetes mellitus and its chronic complications continue to increase alarmingly. Consequently, the massive expenditure on diabetic distal symmetrical polyneuropathy (DSPN) and its sequelae, will also likely rise. Up to 50% of patients with diabetes develop DSPN, and about 20% develop neuropathic pain (painful-DSPN). Painful-DSPN can cast a huge burden on sufferers' lives with increased rates of unemployment, mental health disorders and physical co-morbidities. Unfortunately, due to limited understanding of the mechanisms leading to painful-DSPN, current treatments remain inadequate...
September 7, 2018: Diabetes Research and Clinical Practice
Ichiro Horie, Ai Haraguchi, Ayaka Sako, Junya Akeshima, Tetsuro Niri, Riyoko Shigeno, Ayako Ito, Aya Nozaki, Shoko Natsuda, Satoru Akazawa, Yoshitaka Mori, Takao Ando, Atsushi Kawakami, Norio Abiru
AIMS: To evaluate the glycaemic control of combination therapy with basal insulin and liraglutide, and to explore the factors predictive of efficacy in patients with type 2 diabetes when switched from longstanding basal-bolus insulin therapy. METHODS: We studied 41 patients who switched from basal-bolus insulin therapy of more than 3 years to basal insulin/liraglutide combination therapy. Glycaemic control was evaluated at 6 months after switching therapy and used to subdivide the patients into good-responders (HbA1c <7...
September 5, 2018: Diabetes Research and Clinical Practice
Yinfei Zhang, Kui Peng, Jun Liu, Xiaoou Chen, Tiange Wang, Mian Li, Yuhong Chen, Yu Xu, Jieli Lu, Yufang Bi, Weiqing Wang, Guang Ning, Min Xu
AIMS: We investigated associations of carotid intima-media thickness (CIMT) and carotid plaque with ankle-brachial index (ABI) and toe-brachial index (TBI) in Chinese adults. METHODS: A cross-sectional analysis was performed in 6688 participants from a well-defined community. CIMT was measured with a high-resolution B-mode tomographic ultrasound system. Low ABI was defined as ABI ≤ 0.90. Low TBI was defined as TBI ≤ 0.60. Carotid plaques were classified as normal, homogeneous or heterogeneous according to morphology...
September 4, 2018: Diabetes Research and Clinical Practice
Bianchi Cristina, de Gennaro Giovanni, Romano Matilde, Aragona Michele, Battini Lorella, Del Prato Stefano, Bertolotto Alessandra
AIMS: Both obesity and gestational diabetes (GDM) are risk factors for adverse pregnancy outcomes. The aim of our study is to ascertain the independent role of prepregnancy BMI (pp-BMI), gestational weight gain (GWG), and GDM on pregnancy outcomes. METHODS: We analyzed data of 1198 pregnant women, who underwent selective screening for GDM. Data on pregnancy outcomes was collected from hospital discharge records. RESULTS: Cesarean section (CS) was comparable in GDM and NGT women...
September 3, 2018: Diabetes Research and Clinical Practice
Aleksandra Żebrowska, Barbara Hall, Adam Maszczyk, Rafał Banaś, Joanna Urban
AIMS: Type 1 diabetes mellitus (T1DM) is an important risk factor for cognitive decline and motor dysfunction due to progressive muscular atrophy. Chronic hyperglycemia may be responsible for impaired vascular function, loss of muscle mass, and morphological abnormalities in the myocytes. For the proper functioning of the neuromuscular system, two crucial growth factors are necessary: brain-derived neurotrophic factor (BDNF) and insulin-like growth factor-1 (IGF-1), whose reduced expressions have been implicated in progressive neuropathy and muscle atrophy in patients with T1DM...
September 1, 2018: Diabetes Research and Clinical Practice
Abdullah Alkandari, Joseph C Longenecker, Noël C Barengo, Ahmad Alkhatib, Elisabete Weiderpass, Rihab Al-Wotayan, Qais Al Duwairi, Jaakko Tuomilehto
BACKGROUND: Kuwait ranks among the top 20 countries worldwide in diabetes prevalence. This study's objectives were to assess the prevalence of pre-diabetes and diabetes in Kuwaiti adults. Methods Kuwaiti citizens aged 18-69 years (n=3,915) were studied using the WHÓs STEPwise survey methodology, including its Instrument for Chronic Disease Risk Factor Surveillance. Participants' demographics, medical history, physical measurements and blood biochemistry were assessed. A subset of 2,561 individuals completed all three survey steps, including fasting plasma glucose (FPG) and HbA1c assays...
September 1, 2018: Diabetes Research and Clinical Practice
Tuna Demirdal, Pinar Sen
AIMS: The aim of the study was to evaluate the value of neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR) and lymphocyte to monocyte ratio (LMR) in predicting peripheral arterial disease, peripheral neuropathy, osteomyelitis and need for amputation in diabetic foot infection (DFI). METHODS: A total of 280 patients were analyzed retrospectively. The NLR, PLR and LMR were evaluated statistically in DFI. RESULTS: A total of 280 patients were enrolled in the study...
September 1, 2018: Diabetes Research and Clinical Practice
Adam J Buckley, E Louise Thomas, Nader Lessan, Francesca M Trovato, Guglielmo M Trovato, Simon D Taylor-Robinson
Non-alcoholic fatty liver disease (NAFLD) is a common diagnosis and is increasing in prevalence worldwide. NAFLD is usually asymptomatic at presentation; progression of the disease is unpredictable, leading to the development of a variety of techniques for screening, diagnosis and risk stratification. Clinical methods in current use include serum biomarker panels, hepatic ultrasound, magnetic resonance imaging, and liver biopsy. NAFLD is strongly associated with the metabolic syndrome, and the most common cause of death for people with the condition is cardiovascular disease...
August 28, 2018: Diabetes Research and Clinical Practice
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