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Diabetes Research and Clinical Practice

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https://www.readbyqxmd.com/read/28934667/serum-calcium-changes-and-risk-of-type-2-diabetes-mellitus-in-asian-population
#1
Sunghwan Suh, Ji Cheol Bae, Sang-Man Jin, Jae Hwan Jee, Mi Kyoung Park, Duk Kyu Kim, Jae Hyeon Kim
AIMS: We examined the association between changes in serum calcium levels with the incidence of type 2 diabetes mellitus (T2DM) in apparently healthy South Korean subjects. METHODS: A retrospective longitudinal analysis was conducted with subjects who had participated in comprehensive health check-ups at least four times over a 7-year period (between 2006 and 2012). In total, 23,121 subjects were categorized into tertiles based on changes in their albumin-adjusted serum calcium levels...
September 5, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28926733/epidemiology-of-type-1-diabetes-mellitus-in-basrah-southern-iraq-a-retrospective-study
#2
Dhaighum Almahfoodh, Majid Alabbood, Ahmed Alali, Abbas Mansour
AIMS: To investigate the epidemiology of type 1 diabetes mellitus (T1DM) in Basrah city, Southern Iraq, between 2012 and 2016 among people 0-40year old. METHODS: This was a retrospective data analysis of electronic archives for patients with T1DM registered in Faiha Specialized Diabetes, Endocrine, and Metabolism Center (FDEMC), which is a tertiary referring Center in Basrah. The data include electronic database from August 2008 to February 2016. Incidence and prevalence rates are expressed per 100,000...
September 5, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28934671/the-hnf1a-mutant-ala180val-clinical-challenges-in-determining-causality-of-a-rare-hnf1a-variant-in-familial-diabetes
#3
J V Sagen, L Bjørkhaug, B I Haukanes, L Grevle, J Molnes, B G Nedrebø, O Søvik, P R Njølstad, S Johansson, A Molven
AIMS: Heterozygous mutations in hepatocyte nuclear factor-1A (HNF1A) cause maturity-onset diabetes of the young type 3 (MODY3). Our aim was to compare two families with suspected dominantly inherited diabetes and a new HNF1A variant of unknown clinical significance. METHODS: The HNF1A gene was sequenced in two independently recruited families from the Norwegian MODY Registry. Both familes were phenotyped clinically and biochemically. Microsatellite markers around and within the HNF1A locus were used for haplotyping...
September 1, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28934670/conflicting-interactions-of-apolipoprotein-a-and-high-density-lipoprotein-cholesterol-with-microvascular-complications-of-type-2-diabetes
#4
Zahra Aryan, Mohsen Afarideh, Alireza Ghajar, Sadaf Esteghamati, Alireza Esteghamati, Manouchehr Nakhjavani
AIMS: This study is amid at investigating the associations, and interactions of serum lipid biomarkers with microvascular complications of type 2 diabetes (T2D). METHODS: A nested case-control study was conducted within an ongoing prospective study on patients with T2D. Microvascular complications of T2D including diabetic neuropathy, diabetic retinopathy and diabetic nephropathy were investigated. A total of 444 cases with at least one of the microvascular complications of T2D and 439 age- and gender-matched controls free of any of the chronic microvascular complications of T2D were included...
September 1, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28934669/transforming-growth-factor-beta-tgf-%C3%AE-mediates-cardiac-fibrosis-and-induces-diabetic-cardiomyopathy
#5
REVIEW
Yiyang Yue, Ke Meng, Yuejie Pu, Xiaoming Zhang
Cardiovascular diseases account for the major cause of morbidity and mortality among individuals with diabetes. The diabetic cardiomyopathy (DCM) is a type of diabetic cardiovascular disease, which further directs to the heart failure. The researchers found that diabetes induced cardiac fibrosis plays a vital role in several of the pathological changes that associated with DCM, causing left ventricular hypertrophy (LVH), diastolic dysfunction and systolic dysfunction. However, the mechanisms involved in the pathogenesis of DCM are still elusive...
September 1, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28934668/diabetes-mellitus-increased-all-cause-mortality-rate-among-newly-diagnosed-tuberculosis-patients-in-an-asian-population-a-nationwide-population-based-study
#6
Po-Yen Ko, Shi-Dou Lin, Ming-Chia Hsieh, Yu-Cheng Chen
AIMS: To investigate the effect of diabetes mellitus (DM) on all-cause mortality among patients with newly-diagnosed tuberculosis (TB) in an Asian population. We also identified risk factors for mortality in these patients. METHODS: The data were obtained from the National Health Insurance Research Database and included 9831 newly-diagnosed TB individuals and 1627 TB mortality cases in the period of 2000-2010. The mortality data were divided into a DM group and a non-DM group...
September 1, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28892731/a-new-integrated-care-pathway-for-ambulance-attended-severe-hypoglycaemia-in-the-east-of-england-the-eastern-academic-health-science-network-eahsn-model
#7
Michael Sampson, Marcus Bailey, John Clark, Mark L Evans, Rebekah Fong, Helen Hall, Clare Hambling, Martin Hadley-Brown, Nick Morrish, Helen Murphy, Gerry A Rayman, Karunakaran Vithian, Peter Winocour, Amanda Harries
AIMS: We developed a new clinical integrated pathway linking a regional Ambulance Trust with a severe hypoglycaemia (SH) prevention team. We present clinical data from the first 2000 emergency calls taken through this new clinical pathway in the East of England. METHODS: SH patients attended by Ambulance crew receive written information on SH avoidance, and are contacted for further education through a new regional SH prevention team. All patients are contacted unless they actively decline...
September 1, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28938142/insulin-regimens-and-glycemic-control-in-different-parts-of-europe-over-4years-after-starting-insulin-in-people-with-type-2-diabetes-data-from-the-credit-non-interventional-study
#8
Lawrence Blonde, Michel Marre, Maya Vincent, Sandrine Brette, Valerie Pilorget, Nicholas Danchin, Giacomo Vespasiani, Philip Home
AIMS: A number of insulin regimens are used in type 2 diabetes. This analysis aims to better understand the evolution of insulin therapy in different regions of Europe. METHODS: Data from people starting any insulin were collected in eastern Europe (EEur: Croatia, Russia, Ukraine), northern Europe (NEur: Finland, Germany, UK) and southern Europe (SEur: France, Italy, Portugal, Spain). Retrospective data on starting insulin and prospective follow-up data were extracted from clinical records...
August 31, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28918341/is-first-trimester-hba1c-useful-in-the-diagnosis-of-gestational-diabetes
#9
David Benaiges, Juana A Flores-Le Roux, Irene Marcelo, Laura Mañé, Marta Rodríguez, Xavier Navarro, Juan J Chillarón, Gemma Llauradó, Lucia Gortazar, Juan Pedro-Botet, Antonio Payà
AIMS: To evaluate the usefulness and efficacy of first-trimester HbA1c in the diagnosis of gestational diabetes (GDM). METHODS: Prospective observational of consecutive pregnant women. All women had a first-trimester HbA1c determination and GDM screening at 24-28weeks of pregnancy using a two-step approach. A ROC curve was drawn to determine the sensitivity and specificity of HbA1c in detecting GDM and a rule-in rule-out diagnostic algorithm was proposed. The cost of the proposed algorithm was calculated...
August 30, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28898714/effect-of-follow-up-by-a-hospital-diabetes-care-team-on-diabetes-control-at-one-year-after-discharge-from-the-hospital
#10
Rajesh Garg, Shelley Hurwitz, Raquel Rein, Brooke Schuman, Patricia Underwood, Shreya Bhandari
AIM: This study was conducted to evaluate the effect of continued follow-up by a hospital diabetes team on HbA1c at 1-year after discharge. METHODS: Adults with HbA1c ≥8% (64mmol/mol), undergoing an elective surgery, were treated in the perioperative period and randomized to continued care (CC) or the usual care (UC) after discharge. Patients in the CC group received weekly to monthly phone calls from a diabetes specialist nurse practitioner (NP) to review their home blood glucose values, diet, exercise, and medications...
August 24, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28898713/longitudinal-trends-in-hba1c-and-associations-with-comorbidity-and-all-cause-mortality-in-asian-patients-with-type-2-diabetes-a-cohort-study
#11
Miyang Luo, Wei Yen Lim, Chuen Seng Tan, Yilin Ning, Kee Seng Chia, Rob M van Dam, Wern Ee Tang, Ngiap Chuan Tan, Richard Chen, E Shyong Tai, Kavita Venkataraman
AIMS: This study examined longitudinal trends in HbA1c in a multi-ethnic Asian cohort of diabetes patients, and the associations of these trends with future risk of acute myocardial infarction (AMI), stroke, end stage renal failure (ESRD) and all-cause mortality. METHODS: 6079 participants with type 2 diabetes mellitus in Singapore were included. HbA1c measurements for the five years previous to recruitment were used to identify patterns of HbA1c trends. Outcomes were recorded through linkage with the National Disease Registry...
August 24, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28888147/overweight-hyperglycemia-and-tobacco-use-are-modifiable-risk-factors-for-onset-of-retinopathy-9-and-17years-after-the-diagnosis-of-diabetes-a-retrospective-observational-nation-wide-cohort-study
#12
M Tyrberg, L Nyström, H J Arnqvist, J Bolinder, S Gudbjörnsdottir, M Landin-Olsson, J W Eriksson, M K Svensson
BACKGROUND: The aims of this study were to estimate the risk for diabetic retinopathy (DR) and to identify risk factors. We investigated a nationwide population-based cohort with diabetes diagnosed at age 15-34years. PATIENTS AND METHODS: Of 794 patients registered 1987-1988 in the Diabetes Incidence Study in Sweden (DISS) 444 (56%) patients with retinal photos available for classification of retinopathy participated in a follow-up study 15-19 (median 17) years after diagnosis...
August 24, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28888146/is-there-much-discrepancy-between-glycated-hemoglobin-and-glycated-albumin
#13
LETTER
Takahiro Yajima
No abstract text is available yet for this article.
August 24, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28888993/the-risks-of-nocturnal-hypoglycaemia-in-insulin-treated-diabetes
#14
REVIEW
Alex J Graveling, Brian M Frier
Over half of all episodes of severe hypoglycaemia (requiring external help) occur during sleep, but nocturnal hypoglycaemia is often asymptomatic and unrecognised. The precise incidence of nocturnal hypoglycaemia is difficult to determine with no agreed definition, but continuous glucose monitoring has shown that it occurs frequently in people taking insulin. Attenuation of the counter-regulatory responses to hypoglycaemia during sleep may explain why some episodes are undetected and more prolonged, and modifies cardiovascular responses...
August 23, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28892732/clinical-significance-of-diabetes-likely-induced-by-statins-evidence-from-a-large-population-based-cohort
#15
Giovanni Corrao, Matteo Monzio Compagnoni, Federico Rea, Luca Merlino, Alberico L Catapano, Giuseppe Mancia
AIM: To provide information on the extent to which type 2 diabetes more likely induced by statins affects the risk of macrovascular complications compared to diabetes unlikely induced by statins. METHODS: The 84,828 residents in the Italian Lombardy Region who were newly treated with statins between 2003 and 2005 were followed from the index statin prescription until 2009 (step-1 follow-up) to identify those starting antidiabetic therapy. The proportion of days of follow-up covered by statins measured adherence with statins...
August 19, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28863331/grip-strength-is-not-associated-with-incident-type-2-diabetes-mellitus-in-healthy-adults-the-colaus-study
#16
Pedro Marques-Vidal, Peter Vollenweider, Gérard Waeber, François R Jornayvaz
AIMS: We examined the association of grip strength with incident type 2 diabetes mellitus (T2DM) in healthy subjects initially aged 50 to 75years after a follow-up of 5.5years and 10.7years. METHODS: This was a prospective, population-based study derived from the CoLaus (Cohorte Lausannoise) study including 2318 participants (aged 60.2y; 1354 women) free from T2DM at baseline. Grip strength was assessed using a handheld dynamometer. The effect of grip strength on the incidence of T2DM was analyzed by logistic regression...
August 18, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28863332/screening-for-gestational-diabetes-in-tuscany-italy-a-population-study
#17
Graziano Di Cianni, Elisa Gualdani, Cecilia Berni, Alessandra Meucci, Lorenzo Roti, Cristina Lencioni, Emilia Lacaria, Giuseppe Seghieri, Paolo Francesconi
AIMS: According to current Italian guidelines, only women at higher risk of gestational diabetes (GDM) are eligible for receiving a glucose tolerance test (OGTT) during pregnancy. This study evaluates the compliance to national guidelines, additionally proposing an algorithm able to identify women with GDM. METHODS: The study included 23,270 pregnant women aged >15yr, resident in Tuscany, a region in central Italy, delivering in year 2015, identified by certificates of care at delivery...
August 15, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28888148/hypoglycemia-awareness-among-insulin-treated-patients-with-diabetes-in-malaysia-a-cohort-subanalysis-of-the-hat-study
#18
Zanariah Hussein, Nor Azmi Kamaruddin, Siew Pheng Chan, Anand Jain, Shweta Uppal, Wan Mohamad Wan Bebakar
AIMS: The present Malaysian cohort analysis determined the prevalence of hypoglycemia among patients with type 1 diabetes mellitus (T1DM) or type 2 diabetes mellitus (T2DM) attending primary care- or hospital-based diabetes clinics in Malaysia and their awareness of the symptoms of hypoglycemia. METHODS: The Hypoglycemia Assessment Tool (HAT) study was a non-interventional, 6-month retrospective and 4-week prospective analysis of hypoglycemic events in 24 countries, using self-assessment questionnaires and diaries among patients with T1DM/T2DM aged ≥18years, using insulin for >12months...
August 14, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28869919/cardiometabolic-health-in-asians-with-diabetes-in-the-us
#19
Andy Menke, Sarah Casagrande, Catherine C Cowie
AIMS: Asians develop diabetes at lower levels of adiposity than people of other race/ethnicities. However, there is limited data investigating the health of US Asians with diabetes. We compared cardiovascular risk factors in US Asians to other race/ethnicities stratified by diabetes status. METHODS: Among 4645 adults in the 2011-2014 National Health and Nutrition Examination Survey (NHANES), a cross-sectional survey of the US population, odds ratios were calculated for obesity, hypertension, and elevated low-density lipoprotein (LDL) cholesterol associated with race/ethnicity after adjustment for age, sex, income, education, smoking, alcohol consumption, and health insurance...
August 12, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28834773/genome-wide-dna-methylation-variation-in-maternal-and-cord-blood-of-gestational-diabetes-population
#20
Jessica Kang, Chien-Nan Lee, Hung-Yuan Li, Kai-Han Hsu, Shin-Yu Lin
AIMS: Gestational diabetes mellitus (GDM) has always been a concerning issue for pregnant women. In recent studies, GDM was found to be related to epigenetic modifications, which would alter gene expressions, thus affecting the patients' and their offspring's health, leading to a higher probability of developing metabolic syndromes and diabetes later in life. METHODS: In this study, we collected both maternal and cord blood samples from 16 pregnant women and their newborns, including eight exposed to GDM...
August 9, 2017: Diabetes Research and Clinical Practice
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