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Diabetes Research and Clinical Practice

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https://www.readbyqxmd.com/read/29329778/high-intensity-interval-training-versus-continuous-training-on-physiological-and-metabolic-variables-in-prediabetes-and-type-2-diabetes-a-meta-analysis
#1
REVIEW
Angélica Trevisan De Nardi, Tainara Tolves, Thatiane Larissa Lenzi, Luis Ulisses Signori, Antônio Marcos Vargas da Silva
AIMS: To compare the effects of high-intensity interval training (HIIT) versus moderate-intensity continuous training (MICT) on functional capacity and cardiometabolic markers in individuals prediabetes and type 2 diabetes (T2D). METHODS: The search was performed in PubMed (MEDLINE), EMBASE, PEDro, CENTRAL, Scopus, LILACS database, and Clinical Trials from the inception to July 2017, included randomized clinical trials that compared the use of HIIT and MICT in prediabetes and T2D adults...
January 9, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29329777/dietary-intake-by-food-group-of-individuals-with-type-2-diabetes-mellitus-a-systematic-review
#2
REVIEW
Emily Burch, Lauren Ball, Mari Somerville, Lauren T Williams
AIMS: To synthesise peer-reviewed literature that investigates the dietary intake by food group of individuals with type 2 diabetes mellitus (T2DM) and compare intakes to national and international dietary guidelines. METHODS: Four electronic databases (MEDLINE, EMBASE, CINAHL and Web of Sciences) were searched for studies that investigated the dietary intake of adults (≥18 years) with T2DM using the five main food groups (fruit, vegetables, dairy, grains and meat/meat alternatives)...
January 9, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29325776/prevalence-of-prediabetes-and-diabetes-mellitus-among-adults-residing-in-cameroon-a-systematic-review-and-meta-analysis
#3
REVIEW
Jean Joel Bigna, Jobert Richie Nansseu, Jean-Claude Katte, Jean Jacques Noubiap
AIMS: To summarize current data on the prevalence of prediabetes and diabetes mellitus in Cameroon. METHODS: Population-based cross-sectional studies published between January 1, 2000 and April 30, 2017 including apparently healthy adults residing in Cameroon were searched in PubMed, EMBASE, African Journals Online, and African Index Medicus. We used a random-effects model to pool data. RESULTS: All included studies had a low risk of bias...
January 8, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29325775/nutrigenetic-variants-and-cardio-metabolic-risk-in-women-with-or-without-gestational-diabetes
#4
Marica Franzago, Federica Fraticelli, Daniela Marchetti, Claudio Celentano, Marco Liberati, Liborio Stuppia, Ester Vitacolonna
AIM: Gestational diabetes mellitus (GDM) is the most frequent metabolic disorder in pregnancy and it can be considered a silent risk associated to T2DM and CVD later in life. The aim of this study was to investigate the association of clinical parameters with nine single nucleotide polymorphisms (SNPs) involved with nutrients and metabolism in women with or without GDM in order to identify potential routine clinical markers for early prevention. METHODS: Nine gene variants associated with nutrients and metabolism, namely PPARG2 rs1801282 (C>G); PPARGC1A rs8192678 (C>T); TCF7L2 rs7903146 (C>T); LDLR rs2228671 (C>T); MTHFR rs1801133 (C>T); APOA5 rs662799 (T>C); GCKR rs1260326 (C>T); FTO rs9939609 (T>A); MC4R rs17782313 (T>C) were genotyped in 104 GDM cases and 124 controls using High Resolution Melting (HRM) analysis...
January 8, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29325774/achievement-of-guideline-targets-for-blood-pressure-lipid-and-glycaemic-control-in-type-2-diabetes-a-meta-analysis
#5
REVIEW
Kamlesh Khunti, Antonio Ceriello, Xavier Cos, Christophe De Block
We assessed global achievement of targets recommended by the American Diabetes Association (ADA), European Association for the Study of Diabetes (EASD), and National Institute of Health and Care Excellence (NICE) for type 2 diabetes. We searched Medline, Embase, and The Cochrane Library for observational studies reporting target attainment (2006 to 2017 inclusive) for HbA1c, blood pressure, or lipids (low density lipoprotein cholesterol [LDL-C], high density lipoprotein cholesterol [HDL-C], or triglycerides)...
January 8, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29325773/how-safe-is-metformin-when-initiated-in-early-pregnancy-a-retrospective-5-year-study-of-pregnant-women-with-gestational-diabetes-mellitus-from-india
#6
Vanlalhruaii, Riddhi Dasgupta, Roshna Ramachandran, Jiji E Mathews, Annie Regi, Niranjan Thomas, Vijay Gupta, P Visalakshi, H S Asha, Thomas Paul, Nihal Thomas
BACKGROUND: The initiation of metformin in early pregnancy in Gestational Diabetes mellitus(GDM) remains controversial. The aim of our study was to assess the influence of Metformin on maternal and fetal outcomes when initiated within the first trimester of pregnancy in GDM. METHODS AND MATERIALS: A retrospective analysis of 540 women with diabetes complicating pregnancy (IADPSG criteria) over five years(January 2011 to May 2016)was done. The study population comprised of patients initiated on a)metformin within the first trimester (Group A:n=186),b) metformin after the first trimester(Group B:n=203) and c)insulin at any time during their pregnancy(Group C:n=151)...
January 8, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29325772/the-association-of-snp276g-t-at-adiponectin-gene-with-insulin-resistance-and-circulating-adiponectin-in-response-to-two-different-hypocaloric-diets
#7
Daniel Antonio de Luis, Olatz Izaola, David Primo, R Aller, A Ortola, E Gómez, J J Lopez
BACKGROUND: Several adiponectin gene (ADIPOQ) single nucleotide polymorphisms (SNPS) have been related with adiponectin levels and risk for obesity. OBJECTIVE: The aim of our study was to analyze the effect of rs1501299 ADIPOQ gene polymorphism and dietary intake on total adiponectin levels and insulin resistance after two hypocaloric diets in obese subjects. MATERIAL AND METHODS: A Caucasian population of 284 obese patients was enrolled in a randomized clinical trial with two hypocaloric diets (I: moderate carbohydrates vs II: low fat)...
January 8, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29320718/adiposity-and-family-history-of-type-2-diabetes-in-an-admixed-population-of-adolescents-associations-with-insulin-sensitivity-beta-cell-function-and-hepatic-insulin-extraction-in-brams-study
#8
Daniella F Camilo, Ana Carolina J Vasques, Keila Hayashi, Andrea Tura, Cleliani de Cassia da Silva, Mariana P Zambon, Maria Ângela R de G Monteiro Antônio, Bruno Geloneze
AIMS: Insulin resistance and beta-cell dysfunction manifest differently across racial/ethnic groups, and there is a lack of knowledge regarding the pathophysiology of type 2 diabetes mellitus (T2DM) for ethnically admixed adolescents. This study aimed to investigate the influence of adiposity and family history (FH) of T2DM on aspects of insulin sensitivity, beta-cell function, and hepatic insulin extraction in Brazilian adolescents. METHODS: A total of 82 normoglycemic adolescents were assessed...
January 7, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29317332/safety-and-efficacy-of-sodium-glucose-cotransporter-2-sglt2-inhibitors-in-type-1-diabetes-a-systematic-review-and-meta-analysis
#9
REVIEW
Dana El Masri, Samiran Ghosh, Linda A Jaber
AIMS: Sodium-glucose cotransporter 2 (SGLT2) inhibitors are currently FDA approved for the management of type 2 diabetes. Our objective was to review the available evidence of the effects of SGLT2 inhibitors on HbA1c, body weight, and total daily insulin dose, as well as their safety profile in patients with type 1 diabetes. METHODS: Four randomized controlled trials (RCTs) were identified by conducting a systematic search of PubMed, Embase, Web of Science, Scopus and Cochrane library databases through August 2017...
January 6, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29287839/advantages-of-early-diagnosis-of-diabetic-neuropathy-in-the-prevention-of-diabetic-foot-ulcers
#10
Irene Sanz-Corbalán, José Luis Lázaro-Martínez, Esther García-Morales, Raúl Molines-Barroso, Francisco Álvaro-Afonso, Yolanda García-Álvarez
AIMS: to evaluate the utility of the sudomotor function test (SFT) as a clinical tool in the Risk Stratification System of diabetic patients and to demonstrate the earlier detection of the risk of developing diabetic foot ulcers (DFU) compared to the standard clinical tests. METHODS: prospective follow-up study on 263 patients enrolled consecutively over 3.5 years. Diabetic patients without active DFU were classified according to the International Working Group Risk Stratification System (RSS) and categorized according to the results of the Semmes-Wenstein Monofilament (SWM) and biothesiometer measurements or the SFT...
December 26, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29287838/diabetes-and-complications-of-the-heart-in-sub-saharan-africa-an-urgent-need-for-improved-awareness-diagnostics-and-management
#11
REVIEW
Nadezhda Glezeva, Master Chisale, Kenneth McDonald, Mark Ledwidge, Joe Gallagher, Chris J Watson
Type 2 diabetes mellitus is no longer a disease of high income countries but a global health pandemic. With the continued and rapid increase in its prevalence worldwide it is forecasted that diabetes will be a leading cause of morbidity and mortality. A major concern stems from its role in development and progression of cardiovascular disease, including cardiac dysfunction and heart failure. Within low- and middle-income areas such as Sub-Saharan Africa the burden of diabetes is already significant driven by many factors, including, socioeconomic (urbanisation), nutritional (high-calorie "western-diet", obesity) and lifestyle (physical inactivity) changes...
December 26, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29278713/is-metformin-beneficial-for-heart-failure-in-patients-with-type-2-diabetes
#12
Milton Packer
Heart failure is a common and serious cardiovascular complication of type 2 diabetes. Many antihyperglycemic drugs can increase the risk of heart failure. However, it is commonly believed that metformin - the first-line treatment for type 2 diabetes - reduces the risk of and improves the clinical course of heart failure. It is estimated that 20-25% of patients taking metformin have heart failure. Metformin has been shown to have favorable effects on the course of heart failure in experimental models. Furthermore, when compared with other antihyperglycemic medications in nonrandomized epidemiological studies, metformin users had a lower risk of new-onset heart failure and a lower risk of death if they already had heart failure...
December 23, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29278712/a-national-survey-on-the-efficacy-and-safety-of-continuous-subcutaneous-insulin-infusion-in-patients-with-type-1-diabetes-in-spain
#13
P Beato-Víbora, Ana Chico-Ballesteros, Marga Giménez, Raquel Guerrero-Vázquez, Raquel Barrio-Castellanos, María José Goñi-Iriarte, Gonzalo Díaz-Soto, Juan Francisco Merino-Torres, Jesús Moreno-Fernández, María Asunción Martínez-Brocca
AIMS: To assess safety and benefits of continuous subcutaneous insulin infusion (CSII) therapy in a cohort of type 1 diabetes patients in Spain. METHODS: A web-based national registry was created by the Working Group of the Spanish Diabetes Association. All patients on CSII being followed at selected referral centers were included. A cross-sectional analysis was performed. RESULTS: A total of 1,275 patients were included. Data completion for patients on CSII was 67 ± 32%...
December 23, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29278711/self-efficacy-self-care-and-glycemic-control-in-saudi-arabian-patients-with-type-2-diabetes-mellitus-a-cross-sectional-survey
#14
Ahmad M J Saad, Zeina M H Younes, Hafez Ahmed, Jason A Brown, Rafat M Al Owesie, Ahmed A K Hassoun
AIMS: To determine the prevalence of diabetes self-care activities among type 2 diabetes patients and examine the association between socio-demographic and clinical parameters, diabetes self-care activities, and glycemic control among type 2 diabetes patients. METHODS: A cross sectional study was conducted among patients with diabetes (n=123) at the Sultan Bin Abdulaziz Humanitarian City (SBAHC). A regression model was used to examine the variables that predicted glycemic control...
December 23, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29278710/effects-of-evolving-lipid-lowering-drugs-on-carbohydrate-metabolism
#15
REVIEW
V Tsimihodimos, M Elisaf
The understanding that statins reduce but not eliminate the cardiovascular risk associated with disturbed lipid metabolism and the existence of forms of dyslipidemia that are unresponsive or only partially responsive to statins have led to the development of many novel lipid-lowering drugs. Accumulating evidence suggests that the interplay between carbohydrate and lipid metabolism is bidirectional. Thus, any intervention that affects lipid metabolism has the potential to influence the homeostasis of glucose...
December 23, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29278709/real-world-flash-glucose-monitoring-patterns-and-associations-between-self-monitoring-frequency-and-glycaemic-measures-a-european-analysis-of-over-60-million-glucose-tests
#16
Timothy C Dunn, Yongjin Xu, Gary Hayter, Ramzi A Ajjan
AIMS: Randomised controlled trials demonstrate that using flash glucose monitoring improves glycaemic control but it is unclear whether this applies outside trial conditions. We investigated glucose testing patterns in users worldwide under real life settings to establish testing frequency and association with glycaemic parameters. METHODS: Glucose results were de-identified and uploaded onto a dedicated database once readers were connected to an internet-ready computer...
December 23, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29269136/managing-people-with-diabetes-during-the-cancer-palliation-in-the-era-of-simultaneous-care
#17
REVIEW
Pietro Ferrari, Anna Giardini, Enrica Maria Negri, Giorgio Villani, Pietro Preti
Managing people with diabetes and cancer during palliation constitutes a daunting challenge. Cancer, diabetes and treatment toxicity could be seen as a "Bermuda Triangle" for physician and health care professionals in general. Based on literature review, the present paper stresses the distinctive aspects that diabetes and cancer together involve and bring out. Considering the simultaneous care approach as the basement of our perspective, we explore the areas of palliative intervention for which the specific features of persons with diabetes and cancer emerge: pain manifestation and treatment, response to opioids, psychosocial and communication aspects, infection-related susceptibility and complications...
December 18, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29258886/the-risk-of-fragility-fractures-in-new-users-of-dipeptidyl-peptidase-4-inhibitors-compared-to-sulfonylureas-and-other-anti-diabetic-drugs-a-cohort-study
#18
John-Michael Gamble, Jennifer R Donnan, Eugene Chibrikov, Laurie K Twells, William K Midodzi, Sumit R Majumdar
AIMS: Mixed evidence exists for the effect of incretin-based therapies on osteoporosis in type-2 diabetes. Therefore, we conducted a cohort study to determine the association between dipeptidyl peptidase-4 (DPP-4) inhibitors and common osteoporotic "fragility fractures" (upper extremity, hip, spine). METHODS: The UK-based Clinical Practice Research Datalink was used to identify adults without prior fractures receiving a new anti-diabetic drug or a new type-2 diabetes diagnosis between 2007 and 2016...
December 16, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29253627/potential-serum-biomarkers-for-early-detection-of-diabetic-nephropathy
#19
Tarek Kamal Motawi, Nagwa Ibrahim Shehata, Mahmoud Mohamed ElNokeety, Yasmin Farid El-Emady
AIM: Diabetic nephropathy (DN) is considered as one of the diabetic complications affecting up to 40% of patients with type 1 or type 2 diabetes. In clinical practice, the frequently used markers of renal disease and progression are serum creatinine, estimated glomerular filtration rate (eGFR) and albuminuria. The aim of this study is to determine new biomarkers in human serum which are promising for early detection of DN. METHODS: This study included 50 patients with type 2 diabetes mellitus (T2DM) and 25 clinically healthy individuals...
December 15, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29253626/atlantic-dip-despite-insulin-therapy-in-women-with-iadpsg-diagnosed-gdm-desired-pregnancy-outcomes-are-still-not-achieved-what-are-we-missing
#20
Delia Bogdanet, Aoife Egan, Catriona Reddin, Breda Kirwan, Louise Carmody, Fidelma Dunne
AIMS: To assess if pregnancy outcomes for women with GDM treated with insulin (GDM-I) are comparable to outcomes for women with GDM treated with medical nutritional therapy (MNT) (GDM -M). MATERIALS AND METHODS: This retrospective cohort study included 752 women with GDM-I and 567 women with GDM-M. Maternal and foetal outcomes were examined. RESULTS: Women with GDM-I had a greater risk of polyhydramnios (aOR 2.33, 95%CI 1.31-4.14) and were more likely to deliver by caesarean section (CS) (aOR 1...
December 15, 2017: Diabetes Research and Clinical Practice
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