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Diabetes Research and Clinical Practice

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https://www.readbyqxmd.com/read/29775677/managing-type-2-diabetes-as-a-couple-the-influence-of-partners-beliefs-on-diabetes-distress-over-time
#1
Berry Emma, Davies Mark, Dempster Martin
AIMS: Partners and spouses have an important role in supporting healthy self-care in adults with Type 2 diabetes. While evidence has shown that the beliefs held by people with diabetes influence emotional wellbeing, little is known about the long-term impact of partners' illness beliefs on diabetes distress. METHODS: Persons with Type 2 diabetes (pwt2d) and their partners completed a questionnaire at baseline (N=75 couples) and 12 months later (N=45 couples). Measures included demographic/ clinical parameters, the Revised Illness Perception questionnaire, and the Diabetes Distress Scale...
May 15, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29775676/malondialdehyde-modified-ldl-related-variables-are-associated-with-diabetic-kidney-disease-in-type-2-diabetes
#2
Shoko Furukawa, Hiroaki Suzuki, Kazuya Fujihara, Kazuto Kobayashi, Hitoshi Iwasaki, Yoko Sugano, Shigeru Yatoh, Motohiro Sekiya, Naoya Yahagi, Hitoshi Shimano
BACKGROUND AND AIMS: Oxidized low-density lipoprotein (oxLDL) causes the development of atherosclerosis and kidney injury. Although circulating oxLDL levels were reportedly increased in type 2 diabetic patients with macroalbuminuria, it remains unclear whether albuminuria or the reduced glomerular filtration rate (GFR) is independently associated with the circulating oxLDL level. This study aimed to elucidate the association between the stage of diabetic nephropathy and serum malondialdehyde-modified LDL (MDA-LDL) and the ratio of MDA-LDL to LDL-cholesterol (MDA-LDL/LDL)...
May 15, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29775675/associations-between-angiotensinogen-m235t-polymorphisms-and-the-risk-of-diabetic-nephropathy-a-meta-analysis
#3
Bo Zhou, Min Wen, Ling Mi, Cu-Jiao Hu, Yi Zhang, Jian-Tar Wang, Lei Tang
AIMS: The aim of the present study was to clarify the potential relationship of angiotensinogen (AGT) M235T polymorphism and diabetic nephropathy (DN) risk. METHODS: Comprehensive electronic search in Pubmed, Web of Science, EBSCO, Embase, the Cochrane Library and China National Knowledge Infrastructure (CNKI) to find original articles about the association between AGT M235T polymorphism and DN risk published before 27 September 2017. Literature quality assessment was performed with the Newcastle-Ottawa Scale...
May 15, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29775674/the-prognostic-value-of-the-frontal-qrs-t-angle-is-comparable-to-cardiovascular-autonomic-neuropathy-regarding-long-term-mortality-in-people-with-diabetes-a-population-based-study
#4
O May, C B Graversen, M Ø Johansen, H Arildsen
Cardiovascular autonomic neuropathy (CAN) is a well known prognostic marker in diabetes. A large angle between the QRS- and the T-wave vector (QRS-T angle) in the electrocardiogram (ECG) has recently been introduced as another marker of poor prognosis. AIM: To assess and compare the long-term predictive power of the frontal plane QRS-T angle with CAN in people with diabetes. METHODS: In 1992-93 people with diabetes in the municipality of Horsens, Denmark, were identified by the prescription method andan age and gender stratified sample of 240 individuals with diabetes were randomly selected...
May 15, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29772288/eating-patterns-and-food-intake-of-persons-with-type-1-diabetes-within-the-t1d-exchange
#5
Margaret A Powers, Robin L Gal, Crystal G Connor, Meg Mangan, David M Maahs, Mark A Clements, Elizabeth J Mayer-Davis
AIMS: To identify dietary intake and eating patterns of people with type 1 diabetes from childhood to later adulthood in relation to HbA1c. METHODS: Trained interviewers conducted 24-hour recalls via phone utilizing a multiple pass approach and administered two nutrition questionnaires; 463 participants (or parents of participants) within the T1D Exchange clinic registry were included. Participants were 5 to 81 years with 80-101 participants in five age groups; 56% were female, and 92% were white, with a median diabetes duration of 11...
May 14, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29772287/probiotics-and-nutraceuticals-as-a-new-frontier-in-obesity-prevention-and-management
#6
N Kobyliak, T Falalyeyeva, N Boyko, O Tsyryuk, T Beregova, L Ostapchenko
INTRODUCTION: The beneficial interaction between the microbiota and humans is how bacteria contained within the gut 'talk' to the immune system and in this landscape, probiotics and nutraceuticals play a major role. The study aims to determine whether probiotics plus nutraceuticals such as smectite or omega-3 are superior to probiotic alone on the monosodium glutamate (MSG) induced obesity model in rats. METHODS: Totally, 75 rats divided into five groups were included (n=15, in each)...
May 14, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29772286/prevalence-of-gestational-diabetes-and-subsequent-type-2-diabetes-among-u-s-women
#7
Sarah Stark Casagrande, Barbara Linder, Catherine C Cowie
AIMS: The true prevalence of gestational diabetes (GDM) in the United States is unknown. This study determined the prevalence of GDM and a subsequent diagnosis of diabetes in a nationally representative sample of U.S. women. METHODS: The crude and age-adjusted prevalence of GDM and subsequent diabetes were evaluated by sociodemographic and health-related characteristics among women age ≥20 years in the National Health and Nutrition Examination Surveys, 2007-2014 (N=8,185)...
May 14, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29763710/diabetes-mellitus-in-friedreich-ataxia-a-case-series-of-19-patients-from-the-german-austrian-diabetes-mellitus-registry
#8
Angeliki Pappa, Martin G Häusler, Andreas Veigel, Konstantina Tzamouranis, Martin W Pfeifer, Andreas Schmidt, Martin Bökamp, Holger Haberland, Siegfried Wagner, Joachim Brückel, Gideon de Sousa, Lukas Hackl, Esther Bollow, Reinhard W Holl
Friedreich ataxia (FRDA) is a multisystem autosomal recessive disease with progressive clinical course involving the neuromuscular and endocrine system. Diabetes mellitus (DM) is one typical non-neurological manifestation, caused by beta cell failure and insulin resistance. Because of its rarity, knowledge on DM in FRDA is limited. Based on data from 200 301 patients with DM of the German-Austrian diabetes registry (DPV) and two exemplary patient reports, characteristics of patients with DM and FRDA are compared with classical type 1 or type 2 diabetes...
May 12, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29763709/fenofibrate-effects-on-carotid-artery-intima-media-thickness-in-adults-with-type-2-diabetes-mellitus-a-field-substudy
#9
Jason A Harmer, Anthony C Keech, Anne-Sophie Veillard, Michael R Skilton, Gerald F Watts, David S Celermajer
AIM: Dyslipidemia in type 2 diabetes contributes to an increased risk of cardiovascular disease. Fenofibrate, a lipid-regulating peroxisome proliferator-activated receptor-α (PPARα) agonist, has been shown to reduce vascular complications in adults with type 2 diabetes. The mechanisms for such benefit, however, are not yet well understood. We examined the effects of fenofibrate on carotid intima-media thickness (IMT), a marker of subclinical atherosclerosis, in adults with type 2 diabetes...
May 12, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29746878/effect-of-short-bouts-of-high-intensity-activity-on-glucose-among-adults-with-prediabetes-a-pilot-randomized-crossover-study
#10
Jennifer L Gay, David M Buchner, Melissa L Erickson, Adolphia Lauture
AIM: Few data exist on the effects of vigorous-intensity activity on blood glucose. The study aim was to determine the effects of 2-min and 4-min bouts of vigorous-intensity stair climbing on glucose levels. METHODS: Nine overweight/obese adults with prediabetes (40-64 years, HbA1C 5.7%-6.4%) participated in a randomized cross-over design with three conditions on consecutive days: control; 2-min bouts of stair climbing once per hour for 8 hours; and 4-min bouts of stair climbing once every 2 hours for 8 hours, with the two activity days randomized in order...
May 7, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29733871/gut-microbiota-profiling-in-han-chinese-with-type-1-diabetes
#11
Yun Huang, Si-Cheng Li, Ji Hu, Hai-Bin Ruan, He-Ming Guo, Hong-Hong Zhang, Xin Wang, Yu-Fang Pei, Yang Pan, Chen Fang
AIMS: To investigate whether microbial dysbiosis is associated with T1D in Chinese population and to explore relationships between the composition of gut microbiome and clinical data. METHODS: In this study, we recruited 10 healthy and 12 T1D Han Chinese subjects between the ages of 12 to 33. Fecal samples were collected for DNA extraction and 16S rRNA sequencing, followed by analyses of the gut microbiota composition. RESULTS: Bacterial communities differed between healthy and T1D subjects...
May 4, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29733870/prevalence-and-geographical-distribution-of-insulin-pump-therapy-in-the-central-denmark-region-and-its-association-with-metabolic-parameters
#12
Ulla Kampmann, Lene Ring Madsen, Lasse Bjerg, Daniel R Witte, Kjeld Hasselstrøm, Torben Østergård, Kirsten Alstrup, Marianne Kleis Møller, Dorrit Dylmer, Klavs Würgler Hansen
AIMS: Insulin treatment in type 1 diabetes encompasses multiple daily insulin injections (MDI) or continuous subcutaneous insulin infusion (CSII). Both population-based studies and comparative studies regarding CSII use are sparse. The aim of the current study was to describe the prevalence and distribution of CSII use among adults with type 1 diabetes in the Central Denmark Region and to compare metabolic control in CSII-treated patients to those treated with MDI. METHODS: A database was constructed using the Danish Adult Diabetes Registry in 2014/2015 in combination with an audit of the patients' medical records...
May 4, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29730391/pharmacotherapy-for-hyperglycemia-in-pregnancy-the-new-insulins
#13
REVIEW
Yoel Toledano, Eran Hadar, Moshe Hod
Hyperglycemia in pregnancy may lead to adverse maternal, fetal and neonatal outcomes. Tight glycemic control is prudent in order to reduce pregnancy complications. For many years, the gold standard pharmacological therapy during pregnancy was human insulin. Recently, insulin analogues were also introduced to clinical use in pregnancy. This brief review aims to summarize the information on the efficacy and safety of insulin analogue therapy during gestation. The strengths and pitfalls of insulin analogue administration during gestation, compared with human insulin, are presented...
May 3, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29730390/pre-exercise-blood-glucose-affects-glycemic-variation-of-aerobic-exercise-in-patients-with-type-2-diabetes-treated-with-continuous-subcutaneous-insulin-infusion
#14
Yun Hu, Dan-Feng Zhang, Lu Dai, Zheng Li, Hui-Qin Li, Feng-Fei Li, Bing-Li Liu, Xiao-Juan Sun, Lei Ye, Ke He, Jian-Hua Ma
AIMS: Considering the insulin sensitivity may increase by exercise particularly in patients with type 2 diabetes (T2D), glycemic variation during exercise needs to be studied when the patients are treated with insulin. This study aimed to explore the influence factors of the efficacy and safety of aerobic exercise in patients with T2D treated with Continuous Subcutaneous Insulin Infusion (CSII). METHODS: A total of 267 patients with T2D, treated with CSII, were included...
May 3, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29730389/mothers-with-hip-the-short-term-and-long-term-impact-what-is-new
#15
REVIEW
Federico Mecacci, Serena Ottanelli, Felice Petraglia
Hyperglycemia is one of the most common medical conditions that women encounter during pregnancy and it is due to gestational diabetes (GDM) in the majority of cases [1]. GDM is associated with a higher incidence of maternal morbidity in pregnancy in term of hypertensive disorders/preclampsia and higher rate of cesarean delivery but also with long-term risk of type 2 diabetes and cardiovascular disease. Pregnancy can therefore be considered a stress test; diagnosis of HIP can unmask a preexisting susceptibility and consequently a future risk for type 2 diabetes and can be a useful marker of future cardiovascular risk...
May 3, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29730388/are-the-favorable-cardiovascular-outcomes-of-empagliflozin-treatment-explained-by-its-effects-on-multiple-cardiometabolic-risk-factors-a-simulation-of-the-results-of-the-empa-reg-outcome-trial
#16
Shihchen Kuo, Wen Ye, Justin Duong, William H Herman
AIMS: It is unclear whether the favorable impact of empagliflozin on cardiovascular outcomes (CVOs) is due to its effect on multiple cardiometabolic risk factors (CRFs). METHODS: We used the Michigan Model for Diabetes, a validated computer simulation model, and published data from the EMPA-REG OUTCOME trial to estimate three-year CVOs in the placebo and pooled empagliflozin treatment groups to assess whether the observed benefits might be attributable to differences in CRFs...
May 3, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29730387/white-blood-cells-count-as-an-indicator-to-identify-whether-obesity-leads-to-increased-risk-of-type-2-diabetes
#17
Yeqing Gu, Kuiru Hu, Yuhan Huang, Qing Zhang, Li Liu, Ge Meng, Hongmei Wu, Yang Xia, Xue Bao, Hongbin Shi, Honglei Wang, Shaomei Sun, Xing Wang, Ming Zhou, Qiyu Jia, Kun Song, Kaijun Niu
AIMS: Obesity promotes a variety of poor health outcomes, including type 2 diabetes (T2D). However, not all obese people are at an elevated risk of T2D. Obesity is closely linked to chronic inflammation. In addition, inflammation is an important contributor to T2D via the processes of insulin resistance and islet β-cell failure. Therefore, we hypothesize that white blood cells (WBC) count, a marker of subclinical inflammation,can be used as an indicator to identify whether or not obesity leads to increased risk of T2D...
May 3, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29730386/early-elevated-alkaline-phosphatase-increases-the-risk-of-large-for-gestational-age-birth-weight-in-pregnant-women-with-normal-glucose-tolerance
#18
Yingfeng Liu, Wolin Hou, Xiyan Meng, Weijing Zhao, Jiemin Pan, Junling Tang, Yajuan Huang, Huaping Li, Minfang Tao, Fang Liu
AIMS: The aim of this study was to assess the association between levels of alkaline phosphatase (ALP) in early pregnancy and the incidence of large-for-gestational-age (LGA) neonates in pregnant women without gestational diabetes mellitus. METHODS: A prospective cohort was carried out in 544 women and their biochemical parameters including serum ALP and demographic characteristics were collected in 13-16th gestational week. At 24-28th weeks of gestation, 50g oral glucose challenge test and oral 75 g glucose tolerance test was performed...
May 3, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29729375/clinical-predictive-biomarkers-for-normoalbuminuric-diabetic-kidney-disease
#19
Tomohito Gohda, Yuji Nishizaki, Maki Murakoshi, Shuko Nojiri, Naotake Yanagisawa, Terumi Shibata, Mami Yamashita, Kanako Tanaka, Yoshinori Yamashita, Yusuke Suzuki, Nozomu Kamei
AIMS: A portion of patients with diabetes mellitus follow the progression of a non-albuminuria-based pathway; i.e., normoalbuminuric diabetic kidney disease (NA-DKD). However, the risk factors which determine NA-DKD are not yet fully understood. This cross-sectional study was therefore aimed to investigate the association between various biomarker levels and estimated glomerular filtration rate (eGFR) in patients with type 2 diabetes mellitus and normoalbuminuria (T2D-NA). METHODS: We measured cardiovascular disease (CVD) [serum osteoprotegerin (OPG), plasma brain natriuretic peptide (BNP), cardio-ankle vascular index (CAVI)], tubular damage [urinary L-type fatty acid binding protein (L-FABP)], and inflammatory [serum tumornecrosis factor (TNF) α and its receptors (TNFRs)] biomarkers in 314 patients with T2D-NA...
May 3, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29729374/prevalence-of-health-literacy-and-its-correlates-among-patients-with-type-ii-diabetes-in-kuwait-a-population-based-study
#20
Shaimaa F Hussein, Abdullah Almajran, Ahmed N Albatineh
AIMS: The purpose of this study is to estimate the prevalence of health literacy among patients with type II diabetes and investigate its association with several covariates. No studies were conducted in the Arabian Gulf region characterizing such factors for this population. METHODS: A cross sectional study was implemented in which 359 type II diabetes patients were recruited from diabetes centers across Kuwait. Health literacy was measured by STOFHLA. Multivariate linear regression was applied to investigate the relationship between health literacy and several covariates...
May 2, 2018: Diabetes Research and Clinical Practice
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