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Diabetes Research and Clinical Practice

Abdul Jabbar, Khalifa Abdallah, Ahmed Hassoun, Rachid Malek, Cagri Senyucel, Erik Spaepen, Tamas Treuer, Indranil Bhattacharya
AIM: Current and future estimates of the burden of diabetes in the Middle East and North Africa (MENA) region are among the highest in the world. VISION, an 18-month observational study, explored patterns of insulin initiation and intensification in T2DM patients in the MENA region. METHODS: 1,192 patients aged ≥18 years were enrolled from Algeria, Egypt, Saudi Arabia and the UAE. Treating physicians recorded participants' data. Patient-reported outcomes (PROs) were assessed using questionnaires completed by participants...
January 14, 2019: Diabetes Research and Clinical Practice
Jennifer Saylor, Xiaopeng Ji, Christina J Calamaro, Adam Davey
AIMS: The first aim examined the relationship between sleep behaviors (duration, napping, and social jetlag) and hemoglobin A1c (HbA1c) among emerging young adults (EYAs) with T1DM between 18-25 years old, who are living on a college campus. The second aim characterized the gender differences in glucose management, sleep behaviors, caffeine intake, and nighttime technology. METHODS: A cross-sectional study of eligible participants used a convenience sample of eligible participants...
January 11, 2019: Diabetes Research and Clinical Practice
Susan Down, Aus Alzaid, William H Polonsky, Anne Belton, Steven Edelman, Victoria Gamerman, Friederike Nagel, Jisoo Lee, James Emmerson, Matthew Capehorn
AIMS: Physician-patient communication when discussing the need for additional oral medication for type 2 diabetes (add-on) may affect the self-care of people with this condition. We aimed to investigate physicians' recalled experiences of the add-on consultation. METHODS: We conducted a cross-sectional survey of physicians treating people with type 2 diabetes in 26 countries, as part of a large cross-national study of physician-patient communication during early treatment of type 2 diabetes (IntroDia®)...
January 11, 2019: Diabetes Research and Clinical Practice
Toshiko Takao, Kazuyuki Takahashi, Machi Suka, Nobumi Suzuki, Hiroyuki Yanagisawa
AIMS: To evaluate the effect of postprandial hyperglycemia at clinic visits on all-cause and cancer mortality independent of glycated hemoglobin (HbA1c) levels in a real-world setting in Japanese patients with type 2 diabetes. We also investigated age at death. METHODS: This historical cohort study included 1582 patients with type 2 diabetes who first visited our clinic from 1995 to 1998 and continued visiting for at least 1 year. The patients were followed up through 2017...
January 11, 2019: Diabetes Research and Clinical Practice
Mariko Hayashi, Tomoaki Morioka, Masami Hatamori, Yoshinori Kakutani, Yuko Yamazaki, Masafumi Kurajoh, Koka Motoyama, Katsuhito Mori, Shinya Fukumoto, Atsushi Shioi, Tetsuo Shoji, Masanori Emoto, Masaaki Inaba
AIMS: Omentin is an adipokine that has protective effects against cardiovascular damage. Previous studies showed an inverse relationship between omentin and obesity, diabetes, and cardiovascular disease. This study aimed to investigate the association between omentin and vascular endothelial function in patients with type 2 diabetes (T2D). METHODS: The subjects were 425 patients with T2D and 223 non-diabetic controls. Fasting plasma omentin levels were measured by enzyme-linked immunosorbent assay, and the endothelium-dependent, flow-mediated dilatation (FMD) was measured by ultrasonography...
January 11, 2019: Diabetes Research and Clinical Practice
Senja Masalin, Merja K Laine, Hannu Kautiainen, Mika Gissler, Marko Raina, Pirjo Pennanen, Johan G Eriksson
AIMS: To evaluate the impact of gestational diabetes mellitus (GDM) and maternal height on offspring birthweight. METHODS: This is an observational cohort study, encompassing 4 111 Finnish primiparous women from Vantaa city, Finland, with singleton deliveries between 2009-2015. Data were obtained from the Finnish Medical Birth Register. The study population was divided into five groups according to maternal height. Cut-offs for height levels were I ≤ 158 cm, II 159-163 cm, III 164-167 cm, IV 168-172 cm, V ≥ 173 cm...
January 11, 2019: Diabetes Research and Clinical Practice
Yu-Hsiang Chou, Wei-Chou Lin, Yung-Ming Chen
AIMS: Diabetic nephropathy (DMN) is usually diagnosed clinically without pathology, and the prognosis of which compared to non-diabetic renal diseases has rarely been investigated especially in ethnic Chinese population. Here we reported the outcome of patients with biopsy-proved DMN compared to those with isolated crescentic glomerulonephritis (GN) or lupus nephritis (LN). METHODS: This retrospective observational study included patients with DMN (n=55), crescentic GN (n=48) and LN (n=82) from an original cohort of 987 adult patients who underwent kidney biopsy...
January 11, 2019: Diabetes Research and Clinical Practice
Michael C Riddell, Rubin Pooni, Loren Yavelberg, Zoey Li, Craig Kollman, Ruth E Brown, Aihua Li, Ronnie Aronson
AIMS: Patients with type 1 diabetes (T1D) often report a rise in their blood glucose level following brief intense exercise. We sought to determine the reproducibility of the cardiometabolic responses to high-intensity interval training (HIIT). METHODS: Sixteen adults with T1D, using an optimized multiple daily injection with basal insulin glargine 300 U/mL (Gla-300), performed four fasted HIIT sessions over a 4 to 6-week period. Exercise consisted of high-intensity interval cycling and multimodal training over 25 minutes...
January 11, 2019: Diabetes Research and Clinical Practice
Mohamed Hassanein, Elamin Abdelgadir, Alaaeldin Basheir, Fauzia Rashid, Maryam Al Saeed, Azza Khalifa, Fawzi Eltayb, Sona Abuelkheir, Mohammed Abdellatif, Fatima Sayyah, Suad Khalifa, Fatheya Alawadi
BACKGROUND: Physiology of intermittent and prolonged fasting is known from healthy subjects. Evidence on high and very high-risk groups is lacking. The anticipated risks include hypoglycemia, hyperglycemia, dehydration and thrombosis. Education, pre-Ramadan doses adjustment, and glucose monitoring devices (Optimum diabetes care in Ramadan) is expected to lower this risk. AIMS: We aimed to assess the value of optimum care in diabetes management during Ramadan on the metabolic parameters of high risk patients with diabetes...
January 11, 2019: Diabetes Research and Clinical Practice
Mladen Krnic, Iris Marolt, Marko Skelin, Natasa Grulovic, Dario Rahelic
AIMS: To compare the effectiveness of different titration algorithms for insulin glargine U100 used in everyday practice to achieve glycaemic targets in patients with type 2 diabetes mellitus (T2DM). METHODS: A total of 526 patients (278 in Slovenia, 248 in Croatia) with T2DM (aged ≥18 years) and treated with insulin glargine prior to inclusion were enrolled. Patients self-titrated insulin glargine according to physicians' guidance. RESULTS: Among the 524 patients included in the final analysis, the titration algorithm from the LANMET study was used most commonly (n=368, 70...
January 11, 2019: Diabetes Research and Clinical Practice
Tae Hun Song, Sang Don Lee, Young Eun Ha, Kyung Jin Choi, Sang Hyun Lee, Young-Hoon Kim, Kwee Hyun Suh, Young-Jin Chun
AIMS: The G protein-coupled receptor 119 (GPR119), mainly expressed in the pancreas and gastrointestinal tract, increases the intracellular cyclic AMP accumulation, enhances glucose-dependent insulin secretion from pancreatic β cells, and promotes glucagon-like peptide-1 (GLP-1) production by intestinal L cells. We investigated the activities of a novel GPR119 agonist, HM47118A, in vitro and in vivo. METHODS: In vitro HM47118A activities were evaluated in several cell lines...
January 11, 2019: Diabetes Research and Clinical Practice
Henry J Dethlefs, Elizabeth A Walker, Clyde B Schechter, Rachel Dowd, Linda Filipi, Juan Francisco Garcia, Charles Filipi
AIMS: To describe implementation of diabetes and hypertension program in rural Dominican Republic (DR), and report six years of quality improvement process and health outcomes. METHODS: Dominican teams at two clinics are supported by Chronic Care International with: supervision and continuing education, electronic database, diabetes and hypertension protocols, medications, self-management education materials, behavior change techniques, and equipment and testing supplies (e...
January 11, 2019: Diabetes Research and Clinical Practice
Michael Willis, Christian Asseburg, Cheryl Neslusan
AIMS: Network meta-analyses (NMAs) are valuable ways to generate comparative effectiveness data for therapies available to treat type 2 diabetes mellitus (T2DM). This review assesses NMAs that evaluate sodium glucose co-transporter 2 (SGLT2) inhibitors for treatment of T2DM and discusses potential issues in conducting and interpreting NMAs. METHODS: A systematic literature search was conducted on September 13, 2018 using the search terms "network meta-analysis," "SGLT2," variations of these terms and individual SGLT2 inhibitor names...
January 11, 2019: Diabetes Research and Clinical Practice
Fatima Rodriguez, Manuel R Blum, Titilola Falasinnu, Katherine G Hastings, Jiaqi Hu, Mark R Cullen, Latha P Palaniappan
AIMS: Deaths attributable to diabetes may be underestimated using an underlying cause of death (COD) approach in U.S. death records. This study sought to characterize the burden of diabetes deaths using a multiple-cause of death approach and to identify temporal changes in co-reported causes of death among those with diabetes listed anywhere on their death records. METHODS: COD were identified using data from the National Center for Health Statistics from 2003-2016...
January 11, 2019: Diabetes Research and Clinical Practice
Ushma J Shah, Weijia Xie, Allan Flyvbjerg, John J Nolan, Kurt Højlund, Mark Walker, Caroline L Relton, Hannah R Elliott
AIMS: Epigenetic mechanisms regulate gene expression and may influence the pathogenesis of type 2 diabetes through the loss of insulin sensitivity. The aims of this study were to measure variation in DNA methylation at the type 2 diabetes locus KCNQ1 and assess its relationship with metabolic measures and with genotype. METHODS: DNA methylation from whole blood DNA was quantified using pyrosequencing at 5 CpG sites at the KCNQ1 locus in 510 individuals without diabetes from the 'Relationship between Insulin Sensitivity and Cardiovascular disease' (RISC) cohort...
January 11, 2019: Diabetes Research and Clinical Practice
Andrea Teng, Tony Blakely, Nina Scott, Rawiri Jansen, Bridgette Masters-Awatere, Jeremy Krebs, John Oetzel
AIMS: To examine the incidence of type 2 diabetes in people with newly diagnosed prediabetes and the factors that protect against this progression. METHODS: The study population was 14,043 adults with pre-diabetes enrolled in a primary health organization in the upper North Island of New Zealand. Glycated hemoglobin (HbA1c) and body mass index (BMI) were linked to government health, census and social datasets in the Statistics New Zealand Integrated Data Infrastructure...
January 8, 2019: Diabetes Research and Clinical Practice
Pauline R Myers, Noordeen Shoqirat, Deborah H Allen, Latefa Ali Dardas
BACKGROUND AND PURPOSE: Little is known about the experience of Muslims with diabetes while fasting during Ramadan in the United States. Providing quality care for Muslim patients requires being aware of Islamic beliefs and practices, particularly in regard to healthcare ramifications. Therefore, the aims of this study were to (a) explore the beliefs which influence the experience and practices of diabetes management among Muslims in the United States during Ramadan, and (b) explore perspectives of Muslims with diabetes on their experience with healthcare providers providing support during their fasting experience...
January 8, 2019: Diabetes Research and Clinical Practice
Nancy Elbarbary, Asma Deeb, Abdelhadi Habeb, Salem A Beshyah
AIM: To ascertain the pattern of diabetes management during Ramadan fasting in childhood and adolescence among physicians in Arab countries. METHODS: An online electronic survey questionnaire was distributed to physicians registered in the Arab society for Paediatric Endocrinology and Diabetes (ASPED). RESULTS: Of the 167 responders, 114 (86.0%) were paediatricians and the remaining 14.4% were adult physicians. 117 (79.6%) would allow patients to fast and 60...
January 7, 2019: Diabetes Research and Clinical Practice
David León Jiménez, José Manuel López Chozas, Antonio Espino Montoro, Miguel Ángel Rico Corral, Luis Castilla Guerra, José Pablo Miramontes González
No abstract text is available yet for this article.
December 21, 2018: Diabetes Research and Clinical Practice
Ali Noori-Zadeh, Salar Bakhtiyari, Shokoufeh Khanjari, Karimeh Haghani, Shahram Darabi
AIMS: Apelin is a circulatory blood peptide acting as a ligand for the orphan G protein-coupled receptor known as APJ. Whether apelin blood levels can affect the pathogenesis of type 2 diabetes mellitus is an open question. In the present study, we aimed to assess the levels of circulatory apelin peptide in the type 2 diabetic subjects using systematic review and meta-analysis under random-effects model and standardized mean difference (SMD) as the effect size. For heterogeneity testing, Q and I2 % statistic indices as well as meta-regression were applied...
December 21, 2018: Diabetes Research and Clinical Practice
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