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Diabetes Research and Clinical Practice

Yung-Hsiang Lin, Ko-Jung Chen, Yun-Shing Peng, Pau-Chung Chen, Yao-Hsu Yang
AIMS: The aim of this study was to assess the fertility rate in Taiwanese women before and after a diagnosis of type 1 diabetes. The potential risk factors which may have influenced fertility were also investigated. METHODS: We conducted this retrospective, nationwide, population-based, case-control study using data from the Taiwan National Health Insurance Research Database. The diabetic group (n = 1,191) included women with type 1 diabetes aged between 16 and 30 years in 2000...
July 9, 2018: Diabetes Research and Clinical Practice
D Cavan, L E Makaroff, J da Rocha Fernandes, S Karuranga, M Sylvanowicz, J Conlon, D Chaney, A Malhi, J Barratt
AIM: To assess the level of awareness and provision of screening and treatment for Diabetic Eye Disease (DED) comprising Diabetic Retinopathy (DR) and Diabetic Macular Edema (DME) among health care professionals. METHODS: The study was conducted in two phases. The first phase consisted of a qualitative study, based on semi-structured face-to-face and telephone interviews in 8 countries. The second phase used a quantitative approach utilising online surveys in 41 countries...
July 9, 2018: Diabetes Research and Clinical Practice
Haoyu Zhao, Jeffrey A Johnson, Fatima Al Sayah, Allison Soprovich, Dean T Eurich
AIMS: Self-efficacy is presumed important in chronic disease management; we assessed the association between self-efficacy and risk of hospitalization in adults with type-2 diabetes. METHODS: A prospective cohort was assembled between December 2011 to December 2013. Participants completed an extensive survey, including a previously validated 6-item assessment of chronic disease management self-efficacy. The association between self-efficacy (low, medium, high) and all-cause hospitalization within 1 year of the survey was assessed using multivariable logistic regression, after adjustment for sociodemographic characteristics, physical, behavioral and psychosocial factors...
July 7, 2018: Diabetes Research and Clinical Practice
Aline Fofonka, Patrícia Martins Bock, Karina Rabello Casali, Anderson Donelli da Silveira, Felipe Marques da Rosa, Gabriela Berlanda, Beatriz D Schaan
AIMS: To evaluate the glycemic variability, oxidative stress, metabolic and cardiovascular responses after an aerobic exercise session in patients on treatment with metformin plus vildagliptin or glibenclamide. METHODS: Parallel clinical trial including patients with type 2 diabetes treated with metformin plus vildagliptin or glibenclamide for 12 weeks. Glucose variability, oxidative stress, metabolic (plasma glucose, insulin and glucagon-like-peptide-1) and cardiovascular responses were evaluated at rest, during and after a 30 minute aerobic exercise session (70% of the peak heart rate)...
July 7, 2018: Diabetes Research and Clinical Practice
Noboru Kurinami, Seigo Sugiyama, Hiroko Ijima, Akira Yoshida, Kunio Hieshima, Fumio Miyamoto, Keizo Kajiwara, Katsunori Jinnouch, Tomio Jinnouchi, Hideaki Jinnouchi
AIMS: To investigate whether body composition measures can be used for screening obstructive sleep apnea syndrome (OSAS) in patients with type 2 diabetes mellitus (T2DM) suspected of having OSAS. METHODS: Subjects were 186 hospital inpatients with inadequately controlled T2DM. We measured the respiratory disturbance index (RDI) as an indicator of OSAS using a sheet-type breath detection monitor, defining OSAS as an RDI ≥19 events/hour. Elementary body composition was measured by bioelectrical impedance analysis using InBody770...
July 7, 2018: Diabetes Research and Clinical Practice
Shaukat Sadikot, Chittaranjan N Purandare, Nam H Cho, Moshe Hod
No abstract text is available yet for this article.
July 6, 2018: Diabetes Research and Clinical Practice
(no author information available yet)
No abstract text is available yet for this article.
July 5, 2018: Diabetes Research and Clinical Practice
Kirsten E Peters, Wendy A Davis, John Beilby, Joe Hung, David G Bruce, Timothy M E Davis
AIMS: To investigate the relationship between serum adiponectin, ADIPOQ variants and haplotypes, and cardiovascular disease (CVD) in type 2 diabetes (T2D). METHODS: Baseline data including serum total adiponectin and 21 ADIPOQ polymorphisms were available for 1,076 participants (mean age 64.0 years, 49.4% males) in a community-based cohort followed for an average of 12 years. RESULTS: During 8,843 patient-years of follow-up for coronary heart disease (CHD), 13,494 patient-years for ischaemic stroke (IS) and 12,028 patient-years for heart failure (HF), 40...
June 30, 2018: Diabetes Research and Clinical Practice
Ankia Coetzee, Deidre Mason, David R Hall, Mariza Hoffmann, Magda Conradie
Aim To evaluate antenatal HbA1c at diagnosis and in the 4 weeks preceding delivery to predict early postpartum diabetes mellitus (DM) in women with Gestational Diabetes Mellitus (GDM). Methods Seventy-eight women with GDM were prospectively assessed. The ability of HbA1c at GDM diagnosis (t1) and in the 4 weeks preceding delivery (t2) to predict DM 6-12 weeks after delivery was investigated. Glucose assessment was performed between November 1, 2015, and November 1, 2016 at Tygerberg Hospital (TH), Cape Town, South Africa (SA)...
June 30, 2018: Diabetes Research and Clinical Practice
Øystein Jensen, Tomm Bernklev, Charlotte Gibbs, Ragnar Bekkhus Moe, Dag Hofsø, Lars-Petter Jelsness-Jørgensen
AIM: Fatigue is scarcely studied in type 1 diabetes (T1D), and the aims were to investigate its prevalence compared to the background population, potential associations, and to validate the Fatigue Questionnaire (FQ) in type 1 diabetes. METHODS: Persons with T1D were recruited from three outpatient clinics in Norway. Fatigue was measured using the FQ, and FQ data from the Norwegian background population were used for comparison. Socio-demographic and clinical variables were obtained by self-report, clinical investigation, medical records and laboratory tests...
June 30, 2018: Diabetes Research and Clinical Practice
Mervat Naguib, Laila A Rashed
Autophagy is a major cellular clearance mechanism that maintains cellular survival and homeostasis. Autophagy has a crucial role in the progression of diabetes and kidney diseases. AIMS: To investigate serum concentrations of Beclin-1, a key regulator of autophagy, in patients with diabetic kidney disease (DKD). METHODS: The study included 70 patients with type 2 diabetes and DKD (group 1; 35 patients with estimated glomerular filtration rate (eGFR) ≥ 30 ml/min/1...
June 27, 2018: Diabetes Research and Clinical Practice
Siddharth Narayanan, Gopalakrishnan Loganathan, SriPrakash Mokshagundam, Michael G Hughes, Stuart K Williams, Appakalai N Balamurugan
The intra-islet endothelial cells (ECs), the building blocks of islet microvasculature, govern a number of cellular and pathophysiological processes associated with the pancreatic tissue. These cells are key to the angiogenic process and essential for islet revascularization after transplantation. Understanding fundamental mechanisms by which ECs regulate the angiogenic process is important as these cells maintain and regulate the intra-islet environment facilitated by a complex signaling crosstalk with the surrounding endocrine cells...
June 25, 2018: Diabetes Research and Clinical Practice
André J Scheen
Sodium-glucose cotransporter type 2 inhibitors (SGLT2is) and glucagon-like peptide-1 receptor agonists (GLP-1RAs) are two pharmacological classes that have proven their efficacy to reduce major cardiovascular events (MACEs) in patients with type 2 diabetes mellitus (T2DM) and established cardiovascular disease in large prospective cardiovascular outcome trials (CVOTs): EMPA-REG OUTCOME (empagliflozin), CANVAS (canagliflozin), LEADER (liraglutide) and SUSTAIN 6 (semaglutide). Some heterogeneity appears to exist between the various agents within the two pharmacological classes...
June 23, 2018: Diabetes Research and Clinical Practice
Steven Chih-Yuan Wang, David L Neil, Philip Home
After a century of medical progress, people nowadays live longer with diabetes than ever before. However, current preventative approaches, compounded in part by increased life-expectancy, are failing to reduce the prevalence of diabetes. Cardiovascular sequelae account for many of the four million deaths annually attributable to diabetes. Evidence indicates that certain glucose-lowering medications can improve vascular outcomes in some people with type 2 diabetes, which, together with better understanding of using multiple therapies concurrently, offers opportunities for beneficial personalization of medication regimens...
June 23, 2018: Diabetes Research and Clinical Practice
Hyojung Kang, Jennifer Mason Lobo, Soyoun Kim, Min-Woong Sohn
AIMS: To examine factors that affect cost-related medication non-adherence (CRN), defined as taking medication less than as prescribed because of cost, among adults with diabetes and to determine their relative contribution in explaining CRN. METHODS: Behavioral Risk Factor Surveillance System data for 2013-2014 were used to identify individuals with diabetes and their CRN. We modeled CRN as a function of financial factors, regimen complexity, and other contextual factors including diabetes care, lifestyle, and health factors...
June 23, 2018: Diabetes Research and Clinical Practice
Asger Lund, Filip K Knop
Pancreatic alpha cells are generally considered the only source of glucagon secretion in humans. In the 1970s several groups investigating totally pancreatectomised animals reported that glucagon-like immunoreactive material could be detected in the gastrointestinal tract and reopened the question of an extrapancreatic source of glucagon proposed in 1948 when a hyperglycaemic substance was found in the gastrointestinal tract of dogs and rabbits. Nevertheless, over the years, controversy about the existence of extrapancreatic glucagon has flourished as it proved difficult to accurately measure fully processed 29-amino acid glucagon...
June 23, 2018: Diabetes Research and Clinical Practice
Qiao Zhang, Hang Yuan, Cong Zhang, Yue Guan, Yuqing Wu, Fan Ling, Yucun Niu, Ying Li
AIMS: High levels of circulating free fatty acids (FFAs), inflammation and oxidative stress are important causes for insulin resistance (IR) and type 2 diabetes mellitus. The aim of this study was to investigate the mechanisms of EGCG in alleviating IR in HepG2 cells. METHODS: HepG2 cells were treated with 25 mM glucose, 0.25 mM palmitic acid (PA), or 50 μM EGCG for 24 h. RESULTS: EGCG increased glucose uptake and decreased glucose content...
June 22, 2018: Diabetes Research and Clinical Practice
Serena Low, Kay Chin Jonathon Khoo, Bastari Irwan, Chee Fang Sum, Tavintharan Subramaniam, Su Chi Lim, Tack Keong Michael Wong
AIMS: Triglyceride-Glucose (TyG) is an emerging surrogate indicator of insulin resistance. We explored the role of TyG in development of Type 2 Diabetes Mellitus(T2DM) and elucidated the mechanism for the relationship. METHODS: 4109 subjects without baseline T2DM participated in a community screening programme in 2013-2016. TyG was calculated as Ln[fasting triglyceride level (mg/dl) x fasting plasma glucose (FPG) (mg/dl)/2]. Outcome was T2DM defined as FPG≥7.0 mmol/l; current treatment with anti-diabetes medication; and/or self-reported diabetes on follow-up screening...
June 21, 2018: Diabetes Research and Clinical Practice
Lei Feng, Shiyan Nian, Yang Zhao, Xuejing Bai, Feng Luo, Xuan Luo, Wenbo Xu, Dan Ye, Zongwu Tong
AIMS: To verify the correlations between HbA1c and fasting glucose levels. METHODS: A cross-sectional study with 14,249 Chinese subjects. Objective was evaluated in pooled, age-stratified, HbA1c and fasting glucose-stratified populations. RESULTS: In pooled populations, the Pearson correlation coefficients (PCCs) of males and females were 0.684 (P<0.001) and 0.800 (P<0.001), respectively. HbA1c and fasting glucose maintained significant correlations within the group with HbA1c<6...
June 21, 2018: Diabetes Research and Clinical Practice
Javier Moreno-Ulloa, Aldo Moreno-Ulloa, María Martínez-Tapia, Jorge Duque-Rodríguez
OBJECTIVES: To determine and compare the prevalence and risk factors of metabolic syndrome (MS) among Tarahumara Indians living in rural and urban communities. METHODS: Conducted in 2010, this cross-sectional study included 204 Tarahumara (100 urban and 104 rural individuals 18-75 years old [yo]). Data obtained includes: Anthropometric, lifestyle, blood pressure (BP) and fasting blood tests. Analyses were stratified by gender and age. RESULTS: The total prevalence of MS in rural and urban Tarahumara were 41% and 28% (p=0...
June 21, 2018: Diabetes Research and Clinical Practice
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