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Diabetes Research and Clinical Practice

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https://www.readbyqxmd.com/read/28802698/in-hospital-costs-of-diabetic-foot-disease-treated-by-a-multidisciplinary-foot-team
#1
Willem D Rinkel, Jacky Luiten, Jelle van Dongen, Bram Kuppens, Johan W Van Neck, Suzanne Polinder, Manuel Castro Cabezas, J Henk Coert
BACKGROUND: The diabetic foot imposes significant burden on healthcare systems. Obtaining knowledge on the extent of the costs of diabetic foot ulcers (DFUs) is of value to health care researchers investigating cost-effectiveness of interventions that prevent these costly complications. OBJECTIVES: To estimate the in-hospital costs associated with the treatment of DFUs by a multidisciplinary diabetic foot team. METHODS: Persons with DFUs presenting to our team in 2013 and 2014 were followed and use of care was estimated...
July 29, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28797524/systematic-review-of-metformin-monotherapy-and-dual-therapy-with-sodium-glucose-co-transporter-2-inhibitor-sglt-2-in-treatment-of-type-2-diabetes-mellitus
#2
Nagashekhara Molugulu, Lai Shu Yee, Yew Tze Ye, Tan Chew Khee, Lee Zhen Nie, Neoh Jia Yee, Tian Kar Yee, Tan Chee Liang, Prashant Kesharwani
BACKGROUND: Type 2 Diabetes Mellitus (T2DM) is a chronic disorder and its treatment with only metformin often does not provide optimum glycemic control. Addition of sodium glucose cotransporter 2 inhibitor (SGLT2) will improve the glycemic control in patients on metformin alone. In this study, an attempt is made to investigate the combined therapy of SGLT-2 with metformin in managing T2DM in terms of lowering HbA1c and body weight and monotherapy using metformin alone in HbA1c and body weight reduction...
July 25, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28783527/circulating-early-and-mid-pregnancy-micrornas-and-risk-of-gestational-diabetes
#3
Pandora L Wander, Edward J Boyko, Karin Hevner, Viraj J Parikh, Mahlet G Tadesse, Tanya K Sorensen, Michelle A Williams, Daniel A Enquobahrie
AIMS: Epigenetic regulators, including microRNAs (miRNAs), are implicated in type 2 diabetes, but evidence linking circulating miRNAs in pregnancy and risk of gestational diabetes (GDM) is sparse. Potential modifiers, including pre-pregnancy overweight/obesity and offspring sex, are unexamined. We hypothesized that circulating levels of early-mid-pregnancy (range 7-23weeks of gestation) candidate miRNAs are related to subsequent development of GDM. We also hypothesized that miRNA-GDM associations might vary by pre-pregnancy body-mass index (ppBMI) or offspring sex...
July 25, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28783531/comparison-of-relationships-between-four-common-anthropometric-measures-and-incident-diabetes
#4
Crystal Man Ying Lee, Mark Woodward, Nirmala Pandeya, Robert Adams, Elizabeth Barrett-Connor, Edward J Boyko, Mats Eliasson, Laercio J Franco, Wilfred Y Fujimoto, Clicerio Gonzalez, Barbara V Howard, David R Jacobs, Sirkka Keinanen-Kiukaanniemi, Dianna Magliano, Pamela Schreiner, Jonathan E Shaw, June Stevens, Anne Taylor, Jaakko Tuomilehto, Lynne Wagenknecht, Rachel R Huxley
AIMS: First, to conduct a detailed exploration of the prospective relations between four commonly used anthropometric measures with incident diabetes and to examine their consistency across different population subgroups. Second, to compare the ability of each of the measures to predict five-year risk of diabetes. METHODS: We conducted a meta-analysis of individual participant data on body mass index (BMI), waist circumference (WC), waist-hip and waist-height ratio (WHtR) from the Obesity, Diabetes and Cardiovascular Disease Collaboration...
July 22, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28783528/maternal-body-mass-index-is-a-better-indicator-of-large-for-gestational-age-infants-compared-with-a-75-g-oral-glucose-tolerance-test-in-early-pregnancy-the-jags-trial
#5
Noriyuki Iwama, Takashi Sugiyama, Hirohito Metoki, Hideto Kusaka, Jota Maki, Hidekazu Nishigori, Nobuo Yaegashi, Norimasa Sagawa, Yuji Hiramatsu, Nagayasu Toyoda
AIMS: There is no previous study comparing the predictive ability of maternal pre-pregnancy body mass index (BMI) versus a 75-g oral glucose tolerance test (OGTT) in early pregnancy for large-for-gestational-age (LGA) infants. METHODS: This multi-institutional prospective cohort study included 966 pregnant Japanese women. A multiple logistic regression model was applied to compare the effect size of pre-pregnancy BMI, fasting plasma glucose (PG), and 1- and 2-h PG levels after a 75-g OGTT performed before 22weeks gestation for LGA...
July 22, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28783532/abnormal-circulating-amino-acid-profiles-in-multiple-metabolic-disorders
#6
Akinkunmi Paul Okekunle, Ying Li, Liyan Liu, Shanshan Du, Xiaoyan Wu, Yang Chen, Yanchuan Li, Jiayue Qi, Changhao Sun, Rennan Feng
AIM: To evaluate circulating amino acids (AA) profiles in obesity, type 2 diabetes (T2D) and metabolic syndrome (MetS). METHODS: Serum AA were profiled among 200; healthy, obese, T2D and MetS subjects matched by sex, age and BMI using ultra-high performance liquid chromatography tandem quadruple mass spectrometry (UPLC-TQ-MS). A meta-analysis, including 47 case-control studies (including the current study) on serum AA in obesity, T2D and MetS searched through October 2016 was conducted to explore the AA differences in obesity, T2D and MetS...
July 21, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28802699/relationship-between-limited-joint-mobility-of-hand-and-carotid-atherosclerosis-in-patients-with-type-2-diabetes
#7
Yusuke Mineoka, Michiyo Ishii, Yoshitaka Hashimoto, Muhei Tanaka, Naoto Nakamura, Yasukazu Katsumi, Motohide Isono, Michiaki Fukui
AIM: Limited joint mobility (LJM) of hand, which is one of a complication of diabetic hand, has a close association with diabetic microangiopathy. However, it remains to be elucidated about the relationships between LJM of hand and subclinical atherosclerosis in patients with type 2 diabetes. Therefore, we conducted a cross-sectional study to evaluate the relationships between LJM of hand and carotid intima-media thickness (IMT) and plaque score in patients with type 2 diabetes. METHODS: We evaluated the relationships between LJM of hand, and carotid IMT and plaque score, evaluated by carotid ultrasound examination, in 341 consecutive patients with type 2 diabetes...
July 20, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28783533/predictive-factors-of-developing-type-2-diabetes-mellitus-acute-myocardial-infarction-and-stroke-in-a-cohort-with-impaired-fasting-glucose-in-singapore
#8
Dennis Bingzhu Chia, Lai Yin Wong, Daveon Yu Kai Liu, Matthias Paul Han Sim Toh
AIMS: This study describes the incidence and predictive factors for development of Type II Diabetes Mellitus (T2DM), Acute Myocardial Infarction (AMI) and stroke, among subjects with IFG over a five-year period. METHODS: This is a retrospective cohort study of subjects with newly diagnosed IFG from the Singapore National Healthcare Group hospitals and primary care clinics from 1 January 2008 to 31 December 2010. Clinical data were collected over a five-year period from the date of diagnosis...
July 20, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28778049/a-self-assessment-predictive-model-for-type-2-diabetes-or-impaired-fasting-glycaemia-derived-from-a-population-based-survey
#9
Khairollah Asadollahi, Parisa Asadollahi, Monire Azizi, Ghobad Abangah
AIMS: There is no cure for diabetes and its prevention is interesting for both people and health policy makers. The aim of this study was to construct a simple scoring system to predict diabetes and suggest a self assessment predictive model for type 2 diabetes in Iran. METHODS: This study was a part of a comprehensive population based survey performed in Ilam province during 2011-2012, including 2158 cases≥25years. All demographic and laboratory results were entered into the prepared sheets and were analysed using SPSS 16...
July 20, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28778047/metformin-treatment-significantly-enhances-intestinal-glucose-uptake-in-patients-with-type-2-diabetes-results-from-a-randomized-clinical-trial
#10
Jukka P Koffert, Kirsi Mikkola, Kirsi A Virtanen, Anna-Maria D Andersson, Linda Faxius, Kirsti Hällsten, Mikael Heglind, Letizia Guiducci, Tam Pham, Johanna M U Silvola, Jenni Virta, Olof Eriksson, Saila P Kauhanen, Antti Saraste, Sven Enerbäck, Patricia Iozzo, Riitta Parkkola, Maria F Gomez, Pirjo Nuutila
AIMS: Metformin therapy is associated with diffuse intestinal (18)F-fluoro-deoxyglucose (FDG) accumulation in clinical diagnostics using routine FDG-PET imaging. We aimed to study whether metformin induced glucose uptake in intestine is associated with the improved glycaemic control in patients with type 2 diabetes. Therefore, we compared the effects of metformin and rosiglitazone on intestinal glucose metabolism in patients with type 2 diabetes in a randomized placebo controlled clinical trial, and further, to understand the underlying mechanism, evaluated the effect of metformin in rats...
July 20, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28802700/salivary-extracellular-rna-biomarkers-for-insulin-resistance-detection-in-hispanics
#11
Yong Zhang, Jie Sun, Feng Li, Tristan R Grogan, Jose L Vergara, QingXian Luan, Moon-Soo Park, David Chia, David Elashoff, Kaumudi J Joshipura, David T W Wong
AIMS: Insulin resistance (IR) detection is challenging and no test is currently used in clinical practice. We developed salivary biomarkers that could be used for IR detection. METHODS: We collected saliva from 186 healthy and 276 pre-diabetic participants, divided them into high and low IR groups based on a HOMA cutoff of 2.5. We profiled extracellular transcriptome by microarray in saliva supernatant from 23 high IR and 15 low IR participants, and pre-validated the top ten extracellular mRNA (exRNA) markers in a new cohort of 40 high and 40 low IR participants...
July 19, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28780370/prevention-of-type-2-diabetes-with-the-traditional-chinese-patent-medicine-a-systematic-review-and-meta-analysis
#12
REVIEW
Bing Pang, Feng-Mei Lian, Xi-Yan Zhao, Xue-Min Zhao, De Jin, Yi-Qun Lin, Yu-Jiao Zheng, Qing Ni, Xiao-Lin Tong
AIM: Early interventions in prediabetes can prevent or delay the incidence of type 2 diabetes mellitus (T2DM). The aim of this review was to assess the efficacy and safety of traditional Chinese patent medicine (TCPM) on the prevention of T2DM. METHODS: Seven electronic databases were searched to identify eligible trials published until June 1, 2016. Randomized controlled trials (RCTs) that compared TCPM plus lifestyle modification (LM) versus LM alone were included for in the...
July 19, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28756133/effect-of-nurse-led-randomised-control-trials-on-cardiovascular-risk-factors-and-hba1c-in-diabetes-patients-a-meta-analysis
#13
REVIEW
Barbara Daly, Catherine Jia Lin Tian, Robert Keith Rhodes Scragg
A systematic review and meta-analysis identified 42 randomised control trials comparing a nurse-led intervention with 'usual care' to quantify their effect on glycated haemoglobin (HbA1c) and major cardiovascular risk factors in diabetes patients. All relevant databases were systematically searched for publications to February 2016: MEDLINE, Cochrane Central Register of Controlled Trials, EMBASE and Cumulative Index to Nursing & Allied Health Literature (CINAHL). The 42 trials recruited 9955 diabetes patients (5022 randomised to intervention and 4933 to 'usual care')...
July 14, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28783529/creed-study-hypoglycaemia-during-ramadan-in-individuals-with-type-2-diabetes-mellitus-from-three-continents
#14
Abdul Jabbar, Mohamed Hassanein, Salem A Beshyah, Kristina S Boye, Maria Yu, Steven M Babineaux
AIMS: To describe diabetes treatment and hypoglycaemia in individuals with Type 2 diabetes mellitus during Ramadan. METHODS: A multi-country, retrospective, observational study with data captured before, during, and after Ramadan. We report on a cohort of people (N=3250) with Type 2 diabetes mellitus in four culturally distinct regions: Asia, North Africa, Europe, and the Middle East. RESULTS: During Ramadan, the proportion of participants on oral anti-diabetic medication alone ranged from 68...
July 13, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28779681/sex-and-gender-differences-in-therapy-of-type-2-diabetes
#15
REVIEW
Alexandra Kautzky-Willer, Jürgen Harreiter
Clinical guidelines for the management of type 2 diabetes recommend individual therapy considering age, duration of disease, presence of complication and risk of hypoglycaemia. However, at present, the patient's sex has no impact on clinical decisions. Yet, there is mounting data pointing at biological and psychosocial differences between men and women with great impact on progression of disease and complications. Moreover, choices and preferences of therapeutic strategies as well as adherence to lifestyle and pharmacological interventions differ in both sexes...
July 13, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28778048/risk-stratification-of-patients-with-diabetes-and-the-role-of-sodium-glucose-co-transporter-inhibitors-2-during-ramadan-fasting
#16
Zaina Adnan
The month of Ramadan represents a golden opportunity for better management of patients with diabetes not only during Ramadan month, but also through the entire year. Pre Ramadan period is crucial for evaluating and preparing patients with diabetes intending to Fast Ramadan. The risk stratification categories should take into consideration patients with diabetes having specific conditions such as nephrotic syndrome who are predisposed to thrombosis independent to their estimated glomerular filtration rate and glycated haemoglobin...
July 13, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28759833/anti-oxidative-treatment-with-vitamin-e-improves-peripheral-vascular-function-in-patients-with-diabetes-mellitus-and-haptoglobin-2-2-genotype-a-double-blinded-cross-over-study
#17
Jonia Amer Alshiek, Lior Dayan, Rabea Asleh, Shany Blum, Andrew P Levy, Giris Jacob
Vascular dysfunction in both conduit arteries and small vessels is a major contributor to the development of cardiovascular disease (CVD) in diabetes mellitus (DM). In diabetes there is a process of systemic chronic inflammation accompanied by high oxidative stress causing a subsequent decrease in vascular reactivity and negatively affect the metabolic processes responsible for functioning of the microvasculature. Vitamin E is classified as an antioxidant due to its ability to scavenge lipid radicals and terminate oxidative chain reactions...
July 13, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28750217/association-of-hsd11b1-gene-polymorphisms-with-type-2-diabetes-and-metabolic-syndrome-in-south-indian-population
#18
Nayana Devang, Kapaettu Satyamoorthy, Padmalatha S Rai, M Nandini, Satish Rao, Nagaraja M Phani, Prabha Adhikari
BACKGROUND: 11beta-hydroxysteroid dehydrogenase Type 1 (11β-HSD1) is an NADP or NADPH-dependent enzyme that generates cortisol from cortisone for a local glucocorticoid action. Functional polymorphisms within 11beta-hydroxysteroid dehydrogenase Type 1 (HSD11B1) gene have shown an association with various factors, including insulin resistance (IR) and hypertension. In our study, we have assessed the association of HSD11B1 (rs12086634 and rs846910) gene polymorphisms with type 2 diabetes (T2D) and metabolic syndrome (metS)...
July 13, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28743063/glutamate-pathways-of-the-beta-cell-and-the-control-of-insulin-secretion
#19
REVIEW
Pierre Maechler
Pancreatic beta-cells secrete insulin in response to circulating glucose, thereby maintaining euglycemia. Inside the beta-cell, glucose is transformed into intracellular signals stimulating exocytosis. While calcium is an obligatory messenger, this ion is not sufficient to promote the full secretory response. Accordingly, glucose metabolism produces the additive factor glutamate that participates to an amplifying pathway of the calcium signal. Although intracellular glutamate potentiates insulin secretion, extracellular glutamate may activate ionotropic receptors...
July 12, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28743062/peripheral-leucocytes-and-tissue-gene-expression-of-granzyme-b-perforin-system-and-serpinb9-impact-on-inflammation-and-insulin-resistance-in-coronary-atherosclerosis
#20
Eman F Sanad, Nadia M Hamdy, Adel K El-Etriby, Samer A Sebak, Hala O El-Mesallamy
AIM: The imbalance between proapoptotic granzyme B (GZB)/perforin (PRF) system and proteinase inhibitor-9 (PI-9; serpinB9); the only known inhibitor of human GZB, has been demonstrated in atherosclerosis. However, their role in atherosclerosis with the impact of type 2 diabetes mellitus (DM) as well as their contribution to hallmarks of atherosclerosis is not clear. SUBJECTS AND METHODS: ELISA for serum insulin, high sensitivity C-reactive protein (hsCRP) and GZB levels in atherosclerotic coronary artery diseases (CAD) patients were estimated in comparison to apparently healthy controls, while GZB, PRF and PI-9 mRNA expression levels were quantified by Taqman RT-PCR in both peripheral leucocytes and atherosclerotic tissues...
July 12, 2017: Diabetes Research and Clinical Practice
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