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International Journal of Technology Assessment in Health Care

Thomas G Poder, Christian A Bellemare, Suzanne K Bédard, Jean-François Fisette, Pierre Dagenais
OBJECTIVES: The overarching goal of this research was to (i) evaluate the impact of reports with recommendations provided by a hospital-based health technology assessment (HB-HTA) unit on the local hospital decision-making processes and implementation activities and (ii) identify the underlying factors of the nonimplementation of recommendations. METHODS: All reports produced by the HB-HTA unit between December 2003 and March 2013 were retrieved, and hospital decision makers who requested these reports were solicited for enrolment...
July 19, 2018: International Journal of Technology Assessment in Health Care
Sonal Parasrampuria, Allison H Oakes, Shannon S Wu, Megha A Parikh, William V Padula
OBJECTIVES: Determine the relationship between quality of an accountable care organization (ACO) and its long-term reduction in healthcare costs. METHODS: We conducted a cost minimization analysis. Using Centers for Medicare and Medicaid cost and quality data, we calculated weighted composite quality scores for each ACO and organization-level cost savings. We used Markov modeling to compute the probability that an ACO transitioned between different quality levels in successive years...
July 11, 2018: International Journal of Technology Assessment in Health Care
Linda Mundy, Rebecca Trowman, Brendon Kearney
OBJECTIVES: The Health Technology Assessment International (HTAi) Asia Policy Forum (HAPF) met to discuss the challenges of achieving universal health care (UHC) in Asia. METHODS: Group discussions and presentations at the 2017 HAPF, informed by a background paper, including a literature review and the results of pre-meeting surveys of health technology assessment (HTA) agencies and industry, formed the basis of this article. RESULTS: Affordability was identified as the greatest barrier to establishing UHC; however, other impediments include the lack of political will to implement UHC, and the cultural issue of deference to expert opinion instead of evidence-based assessments...
July 10, 2018: International Journal of Technology Assessment in Health Care
Thomas G Poder, Nathalie Carrier, Suzanne K Bédard
INTRODUCTION: Patients and families play an important role in preventing adverse events. The quality council at our hospital produced a communication tool in considering the main causes of adverse events and requested the health technology assessment (HTA) unit to validate it. OBJECTIVES: Assess the validity of the content of a tablemat sticker as an information tool for hospitalized patients. METHODS: A qualitative validation was first performed with individual interviews and focus groups to evaluate the understanding of the content...
July 10, 2018: International Journal of Technology Assessment in Health Care
Phuong Lien Tran, Caroline Benski, Manuela Viviano, Patrick Petignat, Christophe Combescure, Jeromine Jinoro, Josea Lea Herinianasolo, Pierre Vassilakos
OBJECTIVES: Colposcopes are expensive, heavy, and need specialized technical service, which may outreach the capacity of low-resource settings. Our aim was to assess the performance of smartphone-based digital images for the detection of cervical intraepithelial neoplasia grade 2 or worse (CIN2+). METHODS: Human papillomavirus (HPV)-positive women recruited through a cervical cancer screening campaign had VIA/VILI assessment (visual inspection after application of acetic acid/lugol's iodine)...
June 20, 2018: International Journal of Technology Assessment in Health Care
Yot Teerawattananon, Karlena Luz, Chalarntorn Yothasmutra, Raoh-Fang Pwu, Jeonghoon Ahn, Asrul Akmal Shafie, Kalipso Chalkidou, Sripen Tantivess, Benjarin Santatiwongchai, Waranya Rattanavipapong, Saudamini Dabak
OBJECTIVES: The aim of this study was to describe the historical development of the HTAsiaLink network, draw lessons for other similar initiatives globally, and to analyze key determinants of its success and challenges for its future development. METHODS: This study is based on the collective and direct experiences of the founding members of the HTAsiaLink Network. Data were collected from presentations they made at various international forums and additional information was reviewed...
June 18, 2018: International Journal of Technology Assessment in Health Care
Herbert J A Rolden, Gert Jan van der Wilt, Angela H E M Maas, Janneke P C Grutters
OBJECTIVES: As model-based economic evaluations (MBEEs) are widely used to make decisions in the context of policy, it is imperative that they represent clinical practice. Here, we assess the relevance of MBEEs on dabigatran for the prevention of stroke in patients with atrial fibrillation (AF). METHODS: We performed a systematic review on the basis of a developed questionnaire, tailored to oral anticoagulation in patients with AF. Included studies had a full body text in English, compared dabigatran with a vitamin K antagonist, were not dedicated to one or more subgroup(s), and yielded an incremental cost-effectiveness ratio...
June 18, 2018: International Journal of Technology Assessment in Health Care
Julie Polisena, Rossana Castaldo, Oriana Ciani, Carlo Federici, Simone Borsci, Matteo Ritrovato, Daniel Clark, Leandro Pecchia
OBJECTIVES: Current health technology assessment (HTA) methods guidelines for medical devices may benefit from contributions by biomedical and clinical engineers. Our study aims to: (i) review and identify gaps in the current HTA guidelines on medical devices, (ii) propose recommendations to optimize the impact of HTA for medical devices, and (iii) reach a consensus among biomedical engineers on these recommendations. METHODS: A gray literature search of HTA agency Web sites for assessment methods guidelines on devices was conducted...
June 18, 2018: International Journal of Technology Assessment in Health Care
Seihee Kim, Jinseub Hwang, Min Jee Kim, Jae-Young Lim, Woo Hyung Lee, Ji Eun Choi
OBJECTIVES: Rotator cuff tear is the leading cause of the decline in quality of life for older adults, but comparative evidence on treatment effectiveness is lacking. This study systematically reviewed the effects of various rotator cuff tear treatments through a Bayesian meta-analysis of the related randomized clinical trials (RCTs). METHODS: We searched nine electronic databases for RCTs evaluating rotator cuff tear treatments from their inception through June 2017...
February 22, 2018: International Journal of Technology Assessment in Health Care
Karla Hernandez-Villafuerte, Alastair Fischer, Nicholas Latimer
OBJECTIVES: A primary outcome in oncology trials is overall survival (OS). However, to estimate OS accurately requires a sufficient number of patients to have died, which may take a long time. If an alternative end point is sufficiently highly correlated with OS, it can be used as a surrogate. Progression-free survival (PFS) is the surrogate most often used in oncology, but does not always satisfy the correlation conditions for surrogacy. We analyze the methodologies used when extrapolating from PFS to OS...
January 2018: International Journal of Technology Assessment in Health Care
Oriol de Solà-Morales, David Cunningham, Mathias Flume, Paul M Overton, Natalie Shalet, Stefano Capri
OBJECTIVES: The aim of this study was to investigate how innovation is defined with respect to new medicines. METHODS: MEDLINE, Embase, and EconLit databases were searched for articles published between January 1, 2010 and May 25, 2016 that described a relevant definition of innovation. Identified definitions were analyzed by mapping the concepts described onto a set of ten dimensions of innovation. RESULTS: In total, thirty-six articles were included, and described a total of twenty-five different definitions of innovation...
January 2018: International Journal of Technology Assessment in Health Care
Murray Krahn, Fiona Miller, Ahmed Bayoumi, Ann-Sylvia Brooker, Frank Wagner, Shawn Winsor, Mita Giacomini, Ron Goeree, Holger Schünemann, Gabrielle van der Velde, Stephen Petersen, Nancy Sikich, Irfan Dhalla
OBJECTIVES: In 2007, the Ontario Health Technology Advisory Committee (OHTAC) developed a decision framework to guide decision making around nondrug health technologies. In 2012, OHTAC commissioned a revision of this framework to enhance its usability and deepen its conceptual and theoretical foundations. METHODS: The committee overseeing this work used several methods: (a) a priori consensus on guiding principles, (b) a scoping review of decision attributes and processes used globally in health technology assessment (HTA), (c) presentations by methods experts and members of review committees, and (d) committee deliberations over a period of 3 years...
January 2018: International Journal of Technology Assessment in Health Care
Axel C Mühlbacher, Anika Kaczynski, Franz-Werner Dippel, Susanne Bethge
OBJECTIVES: Severe hypercholesterolemia is a major cause of death in coronary heart disease. New adjunctive drug therapies have passed authorization processes and been launched recently. So far it is not known which properties of the new treatment options generate the highest benefit for patients. The aim was to evaluate patient priorities in the field of adjunctive drug therapy with apheresis. Therapy characteristics were examined as to their relevance to hypercholesterolemia patients...
January 2018: International Journal of Technology Assessment in Health Care
Julie Polisena, Gino De Angelis, David Kaunelis, Iñaki Gutierrez-Ibarluzea
INTRODUCTION: The Health Technology Expert Review Panel is an advisory body to Canadian Agency for Drugs and Technologies in Health (CADTH) that develops recommendations on health technology assessments (HTAs) for nondrug health technologies using a deliberative framework. The framework spans several domains, including the environmental impact of the health technology(ies). Our research objective was to identify articles on frameworks, methods or case studies on the environmental impact assessment of health technologies...
January 2018: International Journal of Technology Assessment in Health Care
Luiza Raquel Grazziotin, Leila Beltrami Moreira, Maria Angelica Pires Ferreira
OBJECTIVES: It is not yet established the advantages between amphotericin B lipid complex (ABLC) and liposomal (L-AmB) in patients with invasive fungal infections refractory to usual doses of conventional AmB (d-AmB), previous renal impairment, or unacceptable d-AmB renal toxicity. This systematic review aims to compare ABLC and L-AmB effectiveness and safety outcomes in these subgroups of patients. METHODS: The search was performed on Medline, Cochrane Library, EMBASE, and LILACS databases...
January 2018: International Journal of Technology Assessment in Health Care
Andres Pichon-Riviere, Natalie Soto, Federico Augustovski, Laura Sampietro-Colom
OBJECTIVES: Latin American countries are taking important steps to expand and strengthen universal health coverage, and health technology assessment (HTA) has an increasingly prominent role in this process. Participation of all relevant stakeholders has become a priority in this effort. Key issues in this area were discussed during the 2017 Latin American Health Technology Assessment International (HTAi) Policy Forum. METHODS: The Forum included forty-one participants from Latin American HTA agencies; public, social security, and private insurance sectors; and the pharmaceutical and medical device industry...
January 2018: International Journal of Technology Assessment in Health Care
Andrés Pichon-Riviere, Natalie C Soto, Federico Ariel Augustovski, Sebastián García Martí, Laura Sampietro-Colom
OBJECTIVES: The aim of this study was to identify good practice principles for health technology assessment (HTA) that are the most relevant and of highest priority for application in Latin America and to identify potential barriers to their implementation in the region. METHODS: HTA good practice principles proposed at the international level were identified and then explored during a deliberative process in a forum of assessors, funders, and product manufacturers...
January 2018: International Journal of Technology Assessment in Health Care
Wija Oortwijn, Laura Sampietro-Colom, Fay Habens, Rebecca Trowman
OBJECTIVES: For many years, several health technology assessment (HTA) agencies scanned the horizon to identify health technologies that were safe, effective and offer value for money. However, there is limited evidence regarding its impact. The role of horizon scanning in preparing health systems for the uptake of new and emerging health technologies was discussed during the 2018 HTA International (HTAi) Global Policy Forum Meeting. METHODS: Reflection of the discussion between seventy-two senior representatives from for-profit, not-for-profit organizations, and HTAi leadership...
January 2018: International Journal of Technology Assessment in Health Care
Petra J Porte, Lisanne M Verweij, Martine C de Bruijne, Cees P M van der Vleuten, Cordula Wagner
OBJECTIVES: The aim of this study was to explore the risk assessment tools and criteria used to assess the risk of medical devices in hospitals, and to explore the link between the risk of a medical device and how those risks impact or alter the training of staff. METHODS: Within a broader questionnaire on implementation of a national guideline, we collected quantitative data regarding the types of risk assessment tools used in hospitals and the training of healthcare staff...
January 2018: International Journal of Technology Assessment in Health Care
Americo Cicchetti, Valentina Iacopino, Silvia Coretti, Alessandra Fiore, Marco Marchetti, Laura Sampietro-Colom, Kristian Kidholm, Jean-Blaise Wasserfallen, Rabia Kahveci, Esa Halmesmäki, Magdalene Rosenmöller, Claudia Wild, Raul-Allan Kivet
OBJECTIVES: Hospital-based health technology assessment (HB-HTA) is becoming increasingly relevant because of its role in managing the introduction and withdrawal of health technologies. The organizational arrangement in which HB-HTA activities are conducted depends on several contextual factors, although the dominant models have several similarities. The aims of this study were to explore, describe, interpret, and explain seven cases of the application of HB-HTA logic and to propose a classification for HB-HTA organizational models which may be beneficial for policy makers and HTA professionals...
January 2018: International Journal of Technology Assessment in Health Care
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