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European Journal of Epidemiology

Andrew Sommerlad, Gayan Perera, Christoph Mueller, Archana Singh-Manoux, Glyn Lewis, Robert Stewart, Gill Livingston
Hospitalisation of people with dementia is associated with adverse outcomes and high costs. We aimed to examine general, i.e. non-psychiatric, hospitalisation rates, changes since 2008 and factors associated with admission. We also aimed to compare admission rates of people with dementia with age-matched people without dementia. We conducted a cohort study of adults ≥ 65 years, with dementia diagnosed during the 2008-2016 study window, derived from a large secondary mental healthcare database in South London, UK...
January 16, 2019: European Journal of Epidemiology
Leslie Grasset, Karine Pérès, Pierre Joly, Camille Sabathé, Alexandra Foubert-Samier, Jean-François Dartigues, Catherine Helmer
The aim of this paper was to investigate the evolution of mortality and life expectancy according to dementia in two French populations 10 years apart. Two different populations of subjects aged 65 or older included in PAQUID from 1988 to 1989 (n = 1342) and 3C from 1999 to 2000 (n = 1996) and initially not demented were followed over 10 years. Dementia was assessed using an algorithmic approach, and participants were considered to have dementia if they had an MMSE score < 24 AND a 4IADL score > 1...
January 16, 2019: European Journal of Epidemiology
Jørn Olsen, Uffe Juul Jensen
Epidemiologists study associations but they are usually interested in causation that could lead to disease prevention. Experience show, however, that many of the associations we identify are not the causes we take an interest in (correlation is not causation). In order to proper translate association into causes, a set of causal criteria was developed 50-60 years ago and they became important tools guiding this translational process (sometimes correlation is causation). Best known of these are the Bradford Hill 'criteria'...
January 16, 2019: European Journal of Epidemiology
Maja Bæksgaard Jørgensen, Jacob Pedersen, Lau Caspar Thygesen, Cathrine Juel Lau, Anne Illemann Christensen, Ulrik Becker, Janne S Tolstrup
The aim of this study was to investigate the association of alcohol consumption and problem drinking on transitions between work, unemployment, sickness absence and social benefits. Participants were 86,417 men and women aged 18-60 years who participated in the Danish National Health Survey in 2010. Information on alcohol consumption (units per week) and problem drinking (CAGE-C score of 4-6) was obtained by questionnaire. The primary outcome was labour market attachment. Information on labour market attachment was obtained from the national administrative registers during a 5-year follow-up period...
January 10, 2019: European Journal of Epidemiology
Frida E Lundberg, Anastasia N Iliadou, Kenny Rodriguez-Wallberg, Kristina Gemzell-Danielsson, Anna L V Johansson
Some studies have suggested that infertility is a risk factor for endometrial, ovarian and breast cancer. The study aimed to create a comprehensive picture of the association between infertility and the risk of ovarian, endometrial and breast cancer, and whether any association could be explained by ovulatory disturbances, endometriosis or nulliparity. In a population-based cohort of 2,882,847 women, cox regression analysis was used to investigate cancer incidence among infertile women. Overall, infertility was associated with a higher incidence rate of ovarian (adjusted hazard ratio [aHR] 1...
January 9, 2019: European Journal of Epidemiology
Vittorio Perduca, Ludmil B Alexandrov, Michelle Kelly-Irving, Cyrille Delpierre, Hanane Omichessan, Mark P Little, Paolo Vineis, Gianluca Severi
An intense scientific debate has recently taken place relating to the "bad luck" hypothesis in cancer development, namely that intrinsic random, and therefore unavoidable, mutagenic events would have a predominant role in tumorigenesis. In this article we review the main contributions to this debate and explain the reasons why the claim that cancer is mostly explained by intrinsic random factors is unsupported by data and theoretical models. In support of this, we present an analysis showing that smoking-induced mutations are more predictive of cancer risk than the lifetime number of stem cell cellular divisions...
January 8, 2019: European Journal of Epidemiology
Virginie Naël, Karine Pérès, Jean-François Dartigues, Luc Letenneur, Hélène Amieva, Angelo Arleo, Anne-Catherine Scherlen, Christophe Tzourio, Claudine Berr, Isabelle Carrière, Cécile Delcourt, Catherine Helmer
To analyze the longitudinal relationships between vision loss and the risk of dementia in the first 2 years, from 2 to 4 years and beyond 4 years after inclusion and to determine the roles of depressive symptomatology and engagement in cognitively stimulating activities in these associations. This study is based on the Three-City (3C) study, a population-based cohort of 7736 initially dementia-free participants aged 65 years and over with 12 years of follow-up. Near visual impairment (VI) was measured and distance visual function (VF) loss was self-reported...
January 4, 2019: European Journal of Epidemiology
Cornelia Huth, Christine von Toerne, Florian Schederecker, Tonia de Las Heras Gala, Christian Herder, Florian Kronenberg, Christa Meisinger, Wolfgang Rathmann, Wolfgang Koenig, Melanie Waldenberger, Michael Roden, Annette Peters, Stefanie M Hauck, Barbara Thorand
The objective of the present study was to identify proteins that contribute to pathophysiology and allow prediction of incident type 2 diabetes or incident prediabetes. We quantified 14 candidate proteins using targeted mass spectrometry in plasma samples of the prospective, population-based German KORA F4/FF4 study (6.5-year follow-up). 892 participants aged 42-81 years were selected using a case-cohort design, including 123 persons with incident type 2 diabetes and 255 persons with incident WHO-defined prediabetes...
December 31, 2018: European Journal of Epidemiology
Jesse Fest, T Rikje Ruiter, Bas Groot Koerkamp, Dimitris Rizopoulos, M Arfan Ikram, Casper H J van Eijck, Bruno H Stricker
Inflammation is a risk factor for morbidity and mortality in the elderly. The neutrophil-to-lymphocyte ratio (NLR) is a marker of systemic inflammation that integrates the information of the leukocyte differentials into one variable. We aimed to assess whether the NLR is a risk indicator for overall and cause-specific mortality in the general population. We analyzed data (2002-2014) from the Rotterdam Study, a long-standing, population-based, prospective cohort study in a community-dwelling ageing population...
December 19, 2018: European Journal of Epidemiology
Toni Meier, Kira Gräfe, Franziska Senn, Patrick Sur, Gabriele I Stangl, Christine Dawczynski, Winfried März, Marcus E Kleber, Stefan Lorkowski
This study was performed to highlight the relationship between single dietary risk factors and cardiovascular diseases (CVDs) in the WHO European Region. We used the comparative risk assessment framework of the Global Burden of Disease Study to estimate CVD mortality attributable to diet; comprising eleven forms of CVDs, twelve food and nutrient groups and 27 risk-outcome pairs in four GBD regions including 51 countries by age and sex between 1990 and 2016. In 2016, dietary risks were associated with 2.1 million cardiovascular deaths (95% uncertainty interval (UI), 1...
December 14, 2018: European Journal of Epidemiology
Thomas C Erren, Philip Lewis
Circadian disruption (CD) was implicated in chains of cancer causation when the International Agency for Research on Cancer classified shift-work involving circadian disruption as probably carcinogenic in 2007. In the following decade, epidemiological studies into causal concepts associated with circadian disruption were inconclusive. Unappreciated complexity with an exclusive focus on shift-work, light-at-night, sleep, and melatonin in regard to circadian disruption may be accountable. With compelling non-epidemiological evidence, we posit that ubiquitous circadian disruption causes cancer and, moreover, that this is unexplored epidemiologically...
December 13, 2018: European Journal of Epidemiology
Henning Tiemeier, Marie C McCormick
No abstract text is available yet for this article.
December 13, 2018: European Journal of Epidemiology
Qiu-Yue Zhong, Leena P Mittal, Margo D Nathan, Kara M Brown, Deborah Knudson González, Tianrun Cai, Sean Finan, Bizu Gelaye, Paul Avillach, Jordan W Smoller, Elizabeth W Karlson, Tianxi Cai, Michelle A Williams
We developed algorithms to identify pregnant women with suicidal behavior using information extracted from clinical notes by natural language processing (NLP) in electronic medical records. Using both codified data and NLP applied to unstructured clinical notes, we first screened pregnant women in Partners HealthCare for suicidal behavior. Psychiatrists manually reviewed clinical charts to identify relevant features for suicidal behavior and to obtain gold-standard labels. Using the adaptive elastic net, we developed algorithms to classify suicidal behavior...
December 10, 2018: European Journal of Epidemiology
Carole Vitellius, Margot Laly, Anne-Sophie Banaszuk, Isabelle Deherce, Nathanaëlle Cornet, Sandrine Bertrais, Patrick Saulnier, François-Xavier Caroli-Bosc
Colorectal cancer (CRC) is a major cause of cancer-related death of worldwide with high incidence and mortality rate, accessible to a screening program in France, first with guaiac- based fecal occult blood test (g-FOBT) then with fecal immunochemical tests (FIT), since 2015, because of better accuracy. The aim of our study was to compare the characteristics of screen-detected lesions in two successive CRC screening campaigns, using two different tests (Hemoccult II® and OC Sensor® ) in the department of Maine-et-Loire, and to precise the performance of these tests [participation rate, detection rates (DR), positive predictive value (PPV)]...
December 8, 2018: European Journal of Epidemiology
Albert Hofman
No abstract text is available yet for this article.
December 5, 2018: European Journal of Epidemiology
Alexandra Doncarli, Virginie Demiguel, Irina Guseva Canu, Véronique Goulet, Sophie Bayart, Thierry Calvez, Sabine Castet, Vincent Dalibard, Yohan Demay, Birgit Frotscher, Jenny Goudemand, Thierry Lambert, Vanessa Milien, Caroline Oudot, Thomas Sannié, Hervé Chambost
FranceCoag is an ongoing open prospective multicentre cohort project aimed at improving epidemiological knowledge about inherited bleeding disorders in France. The main objective of this article was to evaluate the project's progress as of the 30th December 2016. Between 1994 and this date, of the 10,047 patients included in the study, 384 (3.8%) were reported by clinicians to have died and 159 (1.6%) to be lost to follow-up. Among the remaining 9504 patients still being followed up, 5748 (60.5%) had haemophilia A, 1300 (13...
December 5, 2018: European Journal of Epidemiology
Eva Lorenz, Peter Scholz-Kreisel, Dan Baaken, Roman Pokora, Maria Blettner
Most of the pooled analyses and reviews reported an association between radiotherapy for childhood cancer and an increased thyroid cancer risk. Up to now this article presents the first systematic literature review on this association combined with a critical assessment of the methodological quality of the included articles. PubMed and Web of Science databases were searched for relevant articles until May 2016. We included peer-reviewed cohort and case-control studies that investigated an association between radiotherapy for childhood cancer and the occurrence of subsequent thyroid cancer...
December 4, 2018: European Journal of Epidemiology
Xiao-Mei Mai, Vibeke Videm, Nuala A Sheehan, Yue Chen, Arnulf Langhammer, Yi-Qian Sun
Observational studies have shown consistent associations between higher circulating 25-hydroxyvitamin D [25(OH)D] levels and favorable serum lipids. We sought to investigate if such associations were causal. A Mendelian randomization (MR) study was conducted on a population-based cohort comprising 56,435 adults in Norway. A weighted 25(OH)D allele score was generated based on vitamin D-increasing alleles of rs2282679, rs12785878 and rs10741657. Linear regression analyses of serum lipid levels on the allele score were performed to assess the presence of causal associations of serum 25(OH)D with the lipids...
November 21, 2018: European Journal of Epidemiology
Christian Kreis, Eliane Doessegger, Judith E Lupatsch, Ben D Spycher
The aetiology of childhood cancers remains largely unknown. Space-time clustering of cases might imply an aetiological role of infections. We aimed to review the evidence of space-time clustering of specific childhood cancers. We searched Medline and Embase for population-based studies that covered a pre-defined study area, included cases under 20 years of age and were published before July 2016. We extracted all space-time clustering tests and calculated the proportion of positive tests per diagnostic group...
November 16, 2018: European Journal of Epidemiology
Carl Bonander, Ulf Strömberg
No abstract text is available yet for this article.
November 14, 2018: European Journal of Epidemiology
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