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European Journal of Epidemiology

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https://www.readbyqxmd.com/read/28624884/age-at-menarche-and-lung-function-a-mendelian-randomization-study
#1
Dipender Gill, Nuala A Sheehan, Matthias Wielscher, Nick Shrine, Andre F S Amaral, John R Thompson, Raquel Granell, Bénédicte Leynaert, Francisco Gómez Real, Ian P Hall, Martin D Tobin, Juha Auvinen, Susan M Ring, Marjo-Riitta Jarvelin, Louise V Wain, John Henderson, Deborah Jarvis, Cosetta Minelli
A trend towards earlier menarche in women has been associated with childhood factors (e.g. obesity) and hypothesised environmental exposures (e.g. endocrine disruptors present in household products). Observational evidence has shown detrimental effects of early menarche on various health outcomes including adult lung function, but these might represent spurious associations due to confounding. To address this we used Mendelian randomization where genetic variants are used as proxies for age at menarche, since genetic associations are not affected by classical confounding...
June 17, 2017: European Journal of Epidemiology
https://www.readbyqxmd.com/read/28623424/does-air-pollution-trigger-suicide-a-case-crossover-analysis-of-suicide-deaths-over-the-life-span
#2
Lidia Casas, Bianca Cox, Mariska Bauwelinck, Benoit Nemery, Patrick Deboosere, Tim Steve Nawrot
In addition to underlying health disorders and socio-economic or community factors, air pollution may trigger suicide mortality. This study evaluates the association between short-term variation in air pollution and 10 years of suicide mortality in Belgium. In a bidirectional time-stratified case-crossover design, 20,533 suicide deaths registered between January 1st 2002 and December 31st 2011 were matched by temperature with control days from the same month and year. We used municipality-level air pollution [particulate matter (PM10) and O3 concentrations] data and meteorology data...
June 16, 2017: European Journal of Epidemiology
https://www.readbyqxmd.com/read/28608186/incidence-of-glaucomatous-visual-field-loss-after-two-decades-of-follow-up-the-rotterdam-study
#3
Henriët Springelkamp, Roger C Wolfs, Wishal D Ramdas, Albert Hofman, Johannes R Vingerling, Caroline C Klaver, Nomdo M Jansonius
To determine the incidence of glaucomatous visual field loss (GVFL) two decades after the start of the Rotterdam Study, and to compare known risk factors for open-angle glaucoma (OAG) between different clinical manifestations of OAG. Of 6806 participants aged 55 years and older from the population-based Rotterdam Study, 3939 underwent visual field testing at baseline and at least one follow-up round. The ophthalmic examinations included optic disc assessment and measurements of intraocular pressure (IOP), refractive error, diastolic blood pressure (DBP), and height and weight...
June 12, 2017: European Journal of Epidemiology
https://www.readbyqxmd.com/read/28608185/substitutions-of-dairy-product-intake-and-risk-of-stroke-a-danish-cohort-study
#4
Anne Sofie Dam Laursen, Christina Catherine Dahm, Søren Paaske Johnsen, Anne Tjønneland, Kim Overvad, Marianne Uhre Jakobsen
Low fat dairy products are part of dietary guidelines to prevent stroke. However, epidemiological evidence is inconclusive with regard to the association between dairy products and stroke. We therefore investigated associations for substitutions between dairy product subgroups and risk of total stroke and stroke subtypes. We included 55,211 Danish men and women aged 50-64 years without previous stroke. Baseline diet was assessed by a food frequency questionnaire. Cases were identified through a national register and subsequently verified...
June 12, 2017: European Journal of Epidemiology
https://www.readbyqxmd.com/read/28597127/the-interaction-between-smoking-and-hla-genes-in-multiple-sclerosis-replication-and-refinement
#5
Anna Karin Hedström, Michail Katsoulis, Ola Hössjer, Izaura L Bomfim, Annette Oturai, Helle Bach Sondergaard, Finn Sellebjerg, Henrik Ullum, Lise Wegner Thørner, Marte Wendel Gustavsen, Hanne F Harbo, Dragana Obradovic, Milena A Gianfrancesco, Lisa F Barcellos, Catherine A Schaefer, Jan Hillert, Ingrid Kockum, Tomas Olsson, Lars Alfredsson
Interactions between environment and genetics may contribute to multiple sclerosis (MS) development. We investigated whether the previously observed interaction between smoking and HLA genotype in the Swedish population could be replicated, refined and extended to include other populations. We used six independent case-control studies from five different countries (Sweden, Denmark, Norway, Serbia, United States). A pooled analysis was performed for replication of previous observations (7190 cases, 8876 controls)...
June 8, 2017: European Journal of Epidemiology
https://www.readbyqxmd.com/read/28597126/healthcare-and-disease-burden-among-refugees-in-long-stay-refugee-camps-at-lesbos-greece
#6
LETTER
Maaike P J Hermans, Jelmer Kooistra, Suzanne C Cannegieter, Frits R Rosendaal, Dennis O Mook-Kanamori, Banne Nemeth
OBJECTIVES: To assess current medical problems at two Greek refugee sites at Lesbos island (Camp Moria and Caritas hotel), to explore which care is needed and to assess how the provided healthcare can be improved. DESIGN: In this dynamic cohort study all consecutive patients who visited doctors from the Boat Refugee Foundation were included. OUTCOME: Treatment Rates (TR) with 95% Confidence Intervals (95% CI) were calculated for all major health issues...
June 8, 2017: European Journal of Epidemiology
https://www.readbyqxmd.com/read/28585123/occupational-exposure-to-diesel-motor-exhaust-and-risk-of-lung-cancer-by-histological-subtype-a-population-based-case-control-study-in-swedish-men
#7
Anna Ilar, Nils Plato, Marie Lewné, Göran Pershagen, Per Gustavsson
We investigated occupational exposure to diesel motor exhaust (DME) and the risk of lung cancer by histological subtype among men, using elemental carbon (EC) as a marker of DME exposure. 993 cases and 2359 controls frequency-matched on age and year of study inclusion were analyzed by unconditional logistic regression in this Swedish case-control study. Work and smoking histories were collected by a questionnaire and telephone interviews. DME was assessed by a job-exposure matrix. We adjusted for age, year of study inclusion, smoking, occupational exposure to asbestos and combustion products (other than motor exhaust), residential exposure to radon and exposure to air pollution from road traffic...
June 5, 2017: European Journal of Epidemiology
https://www.readbyqxmd.com/read/28585122/long-term-a-posteriori-dietary-patterns-and-risk-of-hip-fractures-in-a-cohort-of-women
#8
Eva Warensjö Lemming, Liisa Byberg, Håkan Melhus, Alicja Wolk, Karl Michaëlsson
Dietary pattern analysis is a useful tool to study the importance of food components in the context of a diet and how they relate to health and disease. The association between dietary patterns and fractures is at present uncertain. We aimed to study associations between dietary patterns and risk of hip fracture in the Swedish Mammography Cohort, including 56,736 women (median baseline age 52 years). Diet data was collected in food frequency questionnaires at two investigations and dietary patterns were defined by principal component analysis using 31 food groups...
June 5, 2017: European Journal of Epidemiology
https://www.readbyqxmd.com/read/28585121/ultra-sensitive-troponin-i-is-an-independent-predictor-of-incident-coronary-heart-disease-in-the-general-population
#9
Bernhard M Kaess, Tonia de Las Heras Gala, Astrid Zierer, Christa Meisinger, Simone Wahl, Annette Peters, John Todd, Christian Herder, Cornelia Huth, Barbara Thorand, Wolfgang Koenig
Troponins are sensitive markers of myocardial injury and predictive of cardiovascular events, but conventional assays fail to detect slightly elevated troponins in a considerable proportion of the general population. Using a novel ultrasensitive assay, we explored the relationship of troponin levels with the incidence of coronary heart disease (CHD) in a case-cohort sample (mean age 52.5 ± 0.2 years, 51.5% women) comprising 803 CHD cases and 1942 non-cases. Ultrasensitive troponin I was detectable in 99...
June 5, 2017: European Journal of Epidemiology
https://www.readbyqxmd.com/read/28585120/occupational-formaldehyde-and-amyotrophic-lateral-sclerosis
#10
Ryan M Seals, Marianthi-Anna Kioumourtzoglou, Ole Gredal, Johnni Hansen, Marc G Weisskopf
Prior studies have yielded inconsistent evidence regarding the association between formaldehyde exposure and amyotrophic lateral sclerosis (ALS). We conducted a population case-control study in the Danish National Registries on the relationship between occupationally-derived formaldehyde exposure and ALS. Occupational history was obtained from a comprehensive and prospectively recorded pension database of all paid work in Denmark since 1964, and was linked to a job-exposure matrix to derive individual exposure estimates...
June 5, 2017: European Journal of Epidemiology
https://www.readbyqxmd.com/read/28573342/a-gaping-research-gap-regarding-the-climate-change-impact-on-health-in-poor-countries
#11
LETTER
Rainer Sauerborn
No abstract text is available yet for this article.
June 1, 2017: European Journal of Epidemiology
https://www.readbyqxmd.com/read/28560537/association-between-childhood-adversity-and-a-diagnosis-of-personality-disorder-in-young-adulthood-a-cohort-study-of-107-287-individuals-in-stockholm-county
#12
Emma Björkenstam, Lisa Ekselius, Bo Burström, Kyriaki Kosidou, Charlotte Björkenstam
Childhood adversity (CA) may increase the risk for later developing of personality disorder (PD). However, less is known about the association between cumulative CA and PD, and the role of childhood psychopathology and school performance. The current study examined the relationship between a range of CAs and a diagnosis of PD in young adulthood, and the roles of childhood psychopathology and school performance in this relationship. All individuals born in Stockholm County 1987-1991 (n = 107,287) constituted our cohort...
May 30, 2017: European Journal of Epidemiology
https://www.readbyqxmd.com/read/28560536/prostate-cancer-incidence-as-an-iceberg
#13
Lorelei A Mucci, Claire H Pernar, Sam Peisch, Travis Gerke, Kathryn M Wilson
No abstract text is available yet for this article.
May 30, 2017: European Journal of Epidemiology
https://www.readbyqxmd.com/read/28560535/the-hidden-epidemic-of-schistosomiasis-in-recent-african-immigrants-and-asylum-seekers-to-italy
#14
LETTER
Anna Beltrame, Dora Buonfrate, Federico Gobbi, Andrea Angheben, Valentina Marchese, Geraldo Badona Monteiro, Zeno Bisoffi
The prevalence of schistosomiasis among recent refugees from sub-Saharan Africa in Italy is unknown. This is a retrospective review of African immigrants screened at Centre for Tropical Diseases of Negrar from March 2014 to February 2016. Of the 373 immigrants tested, 34% were positive at least at one schistosomiasis test. The proportion of positive ELISA serology was 103/373 (27.6%). At microscopy, infected subjects were 65/373 (17.4%), (51% Schistosoma haematobium, 38% Schistosoma mansoni, 11% both). CCA antigen for S...
May 30, 2017: European Journal of Epidemiology
https://www.readbyqxmd.com/read/28551778/screen-detected-gallstone-disease-and-cardiovascular-disease
#15
Daniel Mønsted Shabanzadeh, Tea Skaaby, Lars Tue Sørensen, Torben Jørgensen
Knowledge about temporal associations for screen-detected gallstone disease and cardiovascular disease is limited. The objective of this study was to determine if screen-detected gallstones or cholecystectomy was associated with development of cardiovascular disease. A cohort study of three randomly selected groups from the general population of Copenhagen was performed. Participants (n = 5928) were examined 1982-1992 and underwent abdominal ultrasound examination to detect gallstone disease and were not informed of their gallstone status...
May 27, 2017: European Journal of Epidemiology
https://www.readbyqxmd.com/read/28550648/pregnancy-outcome-in-more-than-5000-births-to-women-with-viral-hepatitis-a-population-based-cohort-study-in-sweden
#16
Knut Stokkeland, Jonas Filip Ludvigsson, Rolf Hultcrantz, Anders Ekbom, Jonas Höijer, Matteo Bottai, Olof Stephansson
Previous studies have shown inconsistent results with respect to hepatitis B (HBV), hepatitis C (HCV) and pregnancy outcome. The aim of this study was to investigate pregnancy outcome in women with HBV or HCV. In a nationwide cohort of births between 2001 and 2011 we investigated the risks of adverse pregnancy outcomes in 2990 births to women with HBV and 2056 births to women with HCV using data from Swedish healthcare registries. Births to women without HBV (n = 1090 979), and births without HCV (n = 1091 913) served as population controls...
May 26, 2017: European Journal of Epidemiology
https://www.readbyqxmd.com/read/28550647/genetic-variation-in-the-adipoq-gene-adiponectin-concentrations-and-risk-of-colorectal-cancer-a-mendelian-randomization-analysis-using-data-from-three-large-cohort-studies
#17
Katharina Nimptsch, Mingyang Song, Krasimira Aleksandrova, Michail Katsoulis, Heinz Freisling, Mazda Jenab, Marc J Gunter, Konstantinos K Tsilidis, Elisabete Weiderpass, H Bas Bueno-De-Mesquita, Dawn Q Chong, Majken K Jensen, Chunsen Wu, Kim Overvad, Tilman Kühn, Myrto Barrdahl, Olle Melander, Karin Jirström, Petra H Peeters, Sabina Sieri, Salvatore Panico, Amanda J Cross, Elio Riboli, Bethany Van Guelpen, Robin Myte, José María Huerta, Miguel Rodriguez-Barranco, José Ramón Quirós, Miren Dorronsoro, Anne Tjønneland, Anja Olsen, Ruth Travis, Marie-Christine Boutron-Ruault, Franck Carbonnel, Gianluca Severi, Catalina Bonet, Domenico Palli, Jürgen Janke, Young-Ae Lee, Heiner Boeing, Edward L Giovannucci, Shuji Ogino, Charles S Fuchs, Eric Rimm, Kana Wu, Andrew T Chan, Tobias Pischon
Higher levels of circulating adiponectin have been related to lower risk of colorectal cancer in several prospective cohort studies, but it remains unclear whether this association may be causal. We aimed to improve causal inference in a Mendelian Randomization meta-analysis using nested case-control studies of the European Prospective Investigation into Cancer and Nutrition (EPIC, 623 cases, 623 matched controls), the Health Professionals Follow-up Study (HPFS, 231 cases, 230 controls) and the Nurses' Health Study (NHS, 399 cases, 774 controls) with available data on pre-diagnostic adiponectin concentrations and selected single nucleotide polymorphisms in the ADIPOQ gene...
May 26, 2017: European Journal of Epidemiology
https://www.readbyqxmd.com/read/28540474/lipid-levels-and-risk-of-venous-thrombosis-results-from-the-mega-study
#18
Vânia M Morelli, Willem M Lijfering, Mettine H A Bos, Frits R Rosendaal, Suzanne C Cannegieter
The relationship between lipid levels and risk of venous thrombosis is not well established. We aimed to assess the association between several lipids and risk of venous thrombosis using data from a population-based case-control study, and to evaluate the underlying mechanism, considering confounding by common risk factors and mediation via hemostatic factors and C-reactive protein. From the Multiple Environmental and Genetic Assessment of risk factors for venous thrombosis (MEGA) study, 2234 patients with a first venous thrombosis and 2873 controls were included...
May 24, 2017: European Journal of Epidemiology
https://www.readbyqxmd.com/read/28534227/overdiagnostic-uncertainty
#19
LETTER
Bjørn Hofmann
No abstract text is available yet for this article.
May 22, 2017: European Journal of Epidemiology
https://www.readbyqxmd.com/read/28527048/interpreting-findings-from-mendelian-randomization-using-the-mr-egger-method
#20
Stephen Burgess, Simon G Thompson
Mendelian randomization-Egger (MR-Egger) is an analysis method for Mendelian randomization using summarized genetic data. MR-Egger consists of three parts: (1) a test for directional pleiotropy, (2) a test for a causal effect, and (3) an estimate of the causal effect. While conventional analysis methods for Mendelian randomization assume that all genetic variants satisfy the instrumental variable assumptions, the MR-Egger method is able to assess whether genetic variants have pleiotropic effects on the outcome that differ on average from zero (directional pleiotropy), as well as to provide a consistent estimate of the causal effect, under a weaker assumption-the InSIDE (INstrument Strength Independent of Direct Effect) assumption...
May 19, 2017: European Journal of Epidemiology
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