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Annals of Saudi Medicine

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https://www.readbyqxmd.com/read/29313528/b-cell-aplasia-and-hypogammaglobulinemia-associated-with-levetiracetam
#1
Hulya Ozdemir, Sua Sumer, Hakan Karabagli, Gokhan Akdemir, A Zafer Caliskaner, Hasibe Artac
Levetiracetam (LEV) is a second-generation antiepileptic drug approved for the treatment of several types of epilepsy. We report a 45-year-old female who developed hypogammaglobulinemia and B cell aplasia during LEV treatment. The Naranjo probability score for an adverse drug reaction was 6. After LEV discontinuation, the number of B cells gradually increased and reached normal levels within two months. This case suggests that monitoring of immunoglobulin levels and lymphocyte subsets analysis is important in patients treated with LEV, especially in cases of prolonged infections...
January 9, 2018: Annals of Saudi Medicine
https://www.readbyqxmd.com/read/29295969/the-saudi-diabetic-kidney-disease-study-saudi-dkd-clinical-characteristics-and-biochemical-parameters
#2
Khalid Siddiqui, Khalid Al-Rubeaan, Mohammed Alghonaim, Amira M Youssef, Dhekra AlNaqeeb
BACKGROUND: Saudi Arabia is facing an epidemic of type 2 diabetes that is complicated by a high rate of chronic complications such as kidney disease, which have a major impact on the healthcare system and economy. The Saudi diabetic kidney disease (SAUDI-DKD) study was launched to understand the implications of chronic diabetic kidney disease . OBJECTIVES: Examine the hematological, biochemical and metabolic parameters of the selected cohorts to look for biomarkers of diabetic nephropathy...
January 3, 2018: Annals of Saudi Medicine
https://www.readbyqxmd.com/read/29289955/association-between-body-mass-index-and-dental-caries-among-special-care-female-children-in-makkah-city
#3
Nisreen Adnan Ashour, Amal Adnan Ashour, Sakeena Basha
BACKGROUND: Dental caries and obesity are multifactorial diseases with diet being a common contributory factor. OBJECTIVE: The main purpose of the present study was to investigate the association between dental caries and obesity among special care female school children in Makkah City, Saudi Arabia. DESIGN: Analytical cross-sectional study. SETTING: Special schools in Makkah City. STUDY POPULATION AND METHODS: Schools were chosen by lottery and female children were ran...
December 31, 2017: Annals of Saudi Medicine
https://www.readbyqxmd.com/read/29229896/recurrence-of-malignant-melanoma-presenting-as-black-colored-pyopneumothorax-a-rare-entity
#4
Ganesh Patel, Anil Saxena, Suman Khangarot, Rajendra Prasad Takhar, Dinesh Patel
We report a 63-year-old patient with black-colored pus (pyopneumothorax) resulting from an infected pleural effusion associated with metastatic malignant melanoma of the skin. The patient was also positive for Pseudomonas, so the color was unexpected. Although rare, malignant melanoma can present as a black pleural effusion due to the presence of melanocytes in the pleural fluid. Black pleural fluid should raise the suspicion of malignant melanoma. SIMILAR CASES PUBLISHED: Nine cases of black pleural effusion due to different causes have been reported...
November 2017: Annals of Saudi Medicine
https://www.readbyqxmd.com/read/29229895/prevalence-and-predictors-of-myocardial-ischemia-by-preoperative-myocardial-perfusion-single-photon-emission-computed-tomography-in-patients-undergoing-noncardiac-surgery
#5
Abdelkareem Saleh Al-Oweidi, Hesham Albabtain, Suleiman M Kharabsheh, Peter Kimme, Mahmoud Almustafa, Samer Seder, Mohamed Shoukri, Ahmed L Fathala
BACKGROUND: The prevalence and predictors of myocardial ischemia before noncardiac surgery are unknown. In addition the predictive value of myocardial perfusion single-photon emission computed tomography (SPECT) before noncardiac in individual patients is uncertain. OBJECTIVE: Evaluate the prevalence and predictors of myocardial ischemia before noncardiac surgery, and determine the postoperative cardiac outcome based on results of myocardial perfusion SPECT. DESIGN: Retrospective...
November 2017: Annals of Saudi Medicine
https://www.readbyqxmd.com/read/29229894/retrospective-review-of-pediatric-status-epilepticus-in-116-saudi-patients-predictors-of-outcome
#6
Raid Harb Hommady, Muhammad Talal Alrifai, Osama Khaled Mubayrik, Ruba Salem Alayed, Muhannad Abdulrahman Alsemari, Ahmed Arumayyan, Waleed Altuwaijri, Duaa Baarmah
BACKGROUND: Status epilepticus (SE) is a common, life-threatening condition. Multiple factors are used to predict its outcome and evaluate its risks, and there have been only a few studies in Saudi Arabia. OBJECTIVES: Investigate predictors of SE outcome. DESIGN: Retrospective chart review study. SETTING: Tertiary center, Riyadh. PATIENTS AND METHODS: We reviewed all pediatric cases (age 14 years or younger) of SE admitted between January 2005 and December 2015, collecting data on age, sex, date of birth, developmental status, pre-existing neurological diseases, SE etiology, Glasgow Outcome Scale (GOS) scores, and electroencephalogram (EEG) findings...
November 2017: Annals of Saudi Medicine
https://www.readbyqxmd.com/read/29229893/prognostic-factors-for-epilepsy-following-first-febrile-seizure-in-saudi-children
#7
Abdullah I Almojali, Anwar E Ahmed, Muhammed Y Bagha
BACKGROUND: Febrile seizure is the most common convulsive event during childhood, but it is generally considered benign. OBJECTIVES: To estimate the rate of epilepsy after first presentation of febrile seizure and to describe factors that can predispose children to have subsequent epilepsy after their first febrile seizure. DESIGN: Retrospective chart review. SETTING: A tertiary care center in Riyadh. PATIENTS AND METHODS: All children whose first febrile seizure developed between 2009-2012, and who were admitted to the pediatric wards...
November 2017: Annals of Saudi Medicine
https://www.readbyqxmd.com/read/29229892/influence-of-body-mass-index-on-severity-of-dental-caries-cross-sectional-study-in-healthy-adults
#8
Majdy Idrees, Mohammad Hammad, Asmaa Faden, Omar Kujan
BACKGROUND: The relationship between body mass index (BMI) and dental caries is still undetermined. OBJECTIVE: This study aimed to assess the relationship between the dental status by decayed, missed, filled teeth index (DMFT), and BMI by age and gender among healthy adults. DESIGN: Analytical, cross-sectional study. SETTINGS: University dental hospital in Riyadh. SUBJECTS AND METHODS: Healthy adults aged between 18 and 35 years were recruited during the 10-month period from March 2015 to December 2015...
November 2017: Annals of Saudi Medicine
https://www.readbyqxmd.com/read/29229891/cost-effectiveness-of-oral-agents-in-relapsing-remitting-multiple-sclerosis-compared-to-interferon-based-therapy-in-saudi-arabia
#9
Mai F Alsaqa'aby, Varun Vaidya, Noura Khreis, Thamer Al Khairallah, Ahmed H Al-Jedai
BACKGROUND: Promising clinical and humanistic outcomes are associated with the use of new oral agents in the treatment of relapsing-remitting multiple sclerosis (RRMS). This is the first cost-effectiveness study comparing these medications in Saudi Arabia. OBJECTIVES: We aimed to compare the cost-effectiveness of fingolimod, teriflunomide, dimethyl fumarate, and interferon (IFN)-b1a products (Avonex and Rebif) as first-line therapies in the treatment of patients with RRMS from a Saudi payer perspective...
November 2017: Annals of Saudi Medicine
https://www.readbyqxmd.com/read/29229890/q192r-polymorphism-in-the-pon1-gene-and-familial-hypercholesterolemia-in-a-saudi-population
#10
Khalid Khalaf Alharbi, May Salem Alnbaheen, Fawiziah Khalaf Alharbi, Rana M Hasanato, Imran Ali Khan
BACKGROUND: Familial hypercholesterolemia (FH) is an autosomal dominant condition characterized by abnormal levels of low-density lipoprotein (LDL) in the blood. FH is a risk factor for atherosclerosis and cardiovascular disease. The relationship between the paraoxonase 1 (PON1) gene, atherosclerosis and coronary artery disease has not been studied in Saudi patients. OBJECTIVE: To investigate the genetic associations of the Q192R polymorphism in the PON1 gene with FH in Saudi patients...
November 2017: Annals of Saudi Medicine
https://www.readbyqxmd.com/read/29229889/admission-of-term-infants-to-the-neonatal-intensive-care-unit-in-a-saudi-tertiary-teaching-hospital-cumulative-incidence-and-risk-factors
#11
Heidi Al-Wassia, Mafaza Saber
BACKGROUND: An increasing number of term infants of appropriate birthweight receive care in neonatal intensive care units (NICUs). OBJECTIVES: This study assessed the prevalence, patterns, and risk factors for admission of term infants to a NICU to identify areas for quality improvement. DESIGN: Cross-sectional analytical study. SETTING: An academic and referral center in Jeddah, Saudi Arabia. PATIENTS AND METHODS: The cases were all term infants (>=37 weeks gestational age) admitted to the NICU between 1 January and 31 December 2015...
November 2017: Annals of Saudi Medicine
https://www.readbyqxmd.com/read/29229888/the-association-between-body-mass-index-and-frequency-of-emergency-department-visits-and-hospitalization-for-asthma-exacerbation-in-a-pediatric-population
#12
Ghadah Abdulrahman Alhekail, Alaa Althubaiti, Sulaiman AlQueflie
BACKGROUND: The prevalence of both asthma and obesity are increasing. Although some studies suggest an association between body mass index (BMI) and frequency of emergency department (ED) visits and hospitalization for asthma exacerbation, any association remains unproven. OBJECTIVE: Estimate the frequency of asthma exacerbation in obese children, and identify any relationship between BMI and frequency of ED visits and hospitalization for asthma exacerbation. DESIGN: Retrospective review of medical records...
November 2017: Annals of Saudi Medicine
https://www.readbyqxmd.com/read/28988256/primary-leiomyosarcoma-of-the-atrium-with-heterologous-differentiation
#13
Shaesta Zaidi, Sufia Husain, Dona Barakah
We report a case of a 47-year-old female who presented with breathlessness and palpitations for two weeks. On clinical evaluation, bilateral pedal edema was noticed. A CT pulmonary angiogram showed a mass in the left atrium causing significant obstruction to cardiovascular outflow. After extensive work-up, the mass was surgically resected. Histopathological findings from the acquired specimen revealed a high-grade leiomyosarcoma with extensive necrosis and heterologous (cartilaginous) differentiation. The early postoperative period was complicated by cardiac tamponade and the patient died on the second postoperative day due to ventricular arrhythmia, shock and multiorgan failure...
September 2017: Annals of Saudi Medicine
https://www.readbyqxmd.com/read/28988255/cardiac-rhythm-recorded-by-implanted-loop-recorder-during-lightning-strike
#14
Ali Altalhi, Waleed Al-Manea, Naif Alqweai, Mohammed Alothman
Lightning strikes cause severe injuries and fatalities. Injuries vary from self-limiting skin manifestations to cardiac arrest and death. Because the event is sudden and unpredictable, assessment of the direct effects of the lightning on the human heart is usually impossible. In this case, a 16-year old boy who had an implanted loop recorder subcutaneous cardiac monitor was hit by lightning during a picnic and survived. A cardiac rhythm strip was recorded live during the strike. SIMILAR CASES PUBLISHED: 0...
September 2017: Annals of Saudi Medicine
https://www.readbyqxmd.com/read/28988254/preoperative-thrombocytosis-as-a-prognostic-factor-in-endometrioid-type-endometrial-carcinoma
#15
Ahmed Abu-Zaid, Mohannad Alsabban, Mohammed Abuzaid, Osama AlOmar, Hany Salem, Ismail A Al-Badawi
BACKGROUND: The impact of preoperative thrombocytosis as a prognostic factor in endometrial carcinoma (EC) remains uncertain and has never been examined in Saudi Arabia. OBJECTIVES: To determine the prevalence of preoperative thrombocytosis (platelet count > 400 000/ μL), and its prognostic significance for clinicopathological factors and survival in Saudi patients with endometrioid-type EC. DESIGN: A retrospective cross-sectional study from January 2010 to December 2013...
September 2017: Annals of Saudi Medicine
https://www.readbyqxmd.com/read/28988253/prevalence-of-congenital-heart-diseases-in-children-with-down-syndrome-in-mansoura-egypt-a-retrospective-descriptive-study
#16
Abdel-Hady El-Gilany, Sohier Yahia, Yahya Wahba
BACKGROUND: The pattern and risk factors for congenital heart diseases (CHD) in children with Down syndrome (DS) vary over time. OBJECTIVES: To update knowledge of the prevalence, types, trends and associated factors for CHD in children with DS in the Egyptian Delta. DESIGN: A retrospective hospital record-based descriptive study. SETTING: A tertiary care center in Mansoura, Egypt during a period of 14 years from 2003 up to 2016...
September 2017: Annals of Saudi Medicine
https://www.readbyqxmd.com/read/28988252/drug-shortages-in-large-hospitals-in-riyadh-a-cross-sectional-study
#17
Yazed Sulaiman AlRuthia, Hadeel AlKofide, Refaa'h AlAjmi, Bander Balkhi, Ahmed Alghamdi, Albandari AlNasser, Areej Alayed, Maali Alshammari, Danah Alsuhaibani, Asma Alathbah
BACKGROUND: Drug shortages are a serious and complex issue in any healthcare system. We conducted this study because the prevalence of drug shortages in Saudi Arabia is largely unknown, while there have been reports of shortages. OBJECTIVE: To explore the prevalence and characteristics of drug shortages as well as identify strategies to minimize their impact on patient care and safety in large hospitals. DESIGN: Questionnaire-based cross-sectional study...
September 2017: Annals of Saudi Medicine
https://www.readbyqxmd.com/read/28988251/efficacy-and-safety-of-a-generic-rosuvastatin-in-a-real-world-setting-prospective-observational-clinical-study-in-lebanese-patients
#18
Mohamad Betto, Jocelyne Fares, Nada Saliba, Hajar Ballout
BACKGROUND: No published studies have assessed the efficacy and safety of rosuvastatin generics. OBJECTIVES: Primary objective to assess the safety and efficacy of a generic rosuvastatin in reducing plasma low-density-lipoprotein cholesterol (LDL-C) in Lebanese dyslipidemic patients. Changes in high-density lipoprotein cholesterol, triglycerides and adverse effects were secondary objectives. DESIGN: Prospective, observational, non-comparative...
September 2017: Annals of Saudi Medicine
https://www.readbyqxmd.com/read/28988250/prevalence-of-glucose-6-phosphate-dehydrogenase-deficiency-in-neonates-in-egypt
#19
Soheir Abo Elella, Mahaa Tawfik, Naglaa Barseem, Wafaa Moustafa
BACKGROUND: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an X-linked disorder which causes neonatal jaundice in most cases, and under certain conditions, can cause a spectrum of hemolytic manifestations. OBJECTIVE: To determine the local prevalence of G6PD deficiency in newborns. DESIGN: Cross-sectional. SETTING: University hospital. METHODS: Infants born during 2015 were prospectively screened for G6PD deficiency...
September 2017: Annals of Saudi Medicine
https://www.readbyqxmd.com/read/28988249/validation-of-the-arabic-version-of-the-score-for-allergic-rhinitis-tool
#20
Sami Alharethy, Mawaheb Al Wedami, Falah Syouri, Almaha A Alqabbani, Abdulsalam Baqays, Tamer Mesallam, Turki Aldrees
BACKGROUND: Allergic rhinitis (AR) is a common inflammation of the nasal mucosa in response to allergen exposure. We translated and validated the Score for Allergic Rhinitis (SFAR) into an Arabic version so that the disease can be studied in an Arabic population. OBJECTIVES: SFAR is a non-invasive self-administered tool that evaluates eight items related to AR. This study aimed to translate and culturally adapt the SFAR questionnaire into Arabic, and assess the validity, consistency, and reliability of the translated version in an Arabic-speaking population of patients with suspected AR...
September 2017: Annals of Saudi Medicine
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