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Diagnostic Cytopathology

Dong Hoon Lee, Tae Mi Yoon, Joon Kyoo Lee, Sang Chul Lim
The case of a fine-needle aspiration biopsy (FNAB) of the patient's salivary gland lesions is considered a rapid, simple, reliable, minimal invasive procedure with markedly rare complications. Herein, we report a case of bleeding from the region of the Wharton's duct after a procedure of a FNAB on the patient's submandibular gland. To our knowledge, this is the first case of bleeding from a salivary duct after a FNAB. For this reason, it is important to recognize that bleeding from the salivary duct after a FNAB can be a rare occurrence...
September 19, 2018: Diagnostic Cytopathology
Daffolyn R Fels Elliott, Britt-Marie Ljung, Rina Patel, Gioia Iezza
Biceps tendon rupture is generally a clinical and radiographic diagnosis, and only rarely presents to the cytopathologist for fine needle aspiration biopsy. We present a case of ruptured biceps tendon associated with a cystic mass of the upper arm that was diagnosed using fine needle aspiration biopsy, and confirmed with subsequent MRI scan. We describe the clinical presentation, cytomorphology, and immunohistochemical profile of the marked chronic inflammatory infiltrate within the synovial fluid. We also provide a discussion of the differential diagnosis for a cystic mass associated with the biceps tendon on cytology...
September 19, 2018: Diagnostic Cytopathology
Oluwatobi E Odetola, Bogdan Isaila, Stefan E Pambuccian, Güliz A Barkan
Renal transplant recipients are at increased risk of developing urologic malignancies, some of which are associated with prolonged BK virus infection. We report two cases of BK virus-associated carcinoma with variant morphological patterns (clear cell adenocarcinoma of the bladder and micropapillary urothelial carcinoma of the pelvicaliceal system) arising in the urinary tract of renal transplant recipients. In both cases, the diagnosis was initially established on cytologic specimens: on urine cytology in one patient and on fine needle aspiration of an inguinal lymph node in the other patient...
September 12, 2018: Diagnostic Cytopathology
C W Michael, W Faquin, X Jing, F Kaszuba, J Kazakov, E Moon, E Toloza, R I Wu, A L Moreira
The Papanicolaou Society of Cytopathology has developed a set of guidelines for pulmonary cytology including indications for bronchial brushings, washings, and endobronchial ultrasound guided transbronchial fine-needle aspiration (EBUS-TBNA), technical recommendations for cytological sampling, recommended terminology and classification schemes, recommendations for ancillary testing and recommendations for post-cytological management and follow-up. All recommendations are based on the expertise of the authors, an extensive literature review and feedback from presentations at national and international conferences...
September 8, 2018: Diagnostic Cytopathology
Natália Batista Daroit, Arthur Pias Salgueiro, Fábio Luiz Dal Moro Maito, Fernanda Visioli, Pantelis Varvaki Rados
Early detection of oral squamous cell carcinoma (OSCC) is a challenge for oral surgeons, as clinical features are not always classical. Cytopathological assays can help identify alterations at the cellular level. This article reports a case of OSCC in a young male adult without exposure to classical risk factors. The histopathological examination showed a micro invasive carcinoma invading the connective tissue. Cytopathological results showed a higher percentage of cells in deeper epithelial layers; the cytomorphometric examination revealed a nuclear/cytoplasmic ratio of 0...
September 8, 2018: Diagnostic Cytopathology
Huiya Huang, Tamara Giorgadze
Synchronous tumors represent a very small portion of pancreatic tumors. Although there is a higher incidence of secondary malignant neoplasms (SMN) in patients with history of Wilms tumor (WT), pancreatic tumors are very infrequent SMNs in this population. We report the first case of synchronous pancreatic tumors in a patient with history of WT. Two separated pancreatic lesions were identified by abdominal computerized tomography (CT) scan. Fine-needle aspiration of both lesions was performed for cytopathology examination...
September 8, 2018: Diagnostic Cytopathology
Erika E Doxtader, Charles D Sturgis, Kathryn S Dyhdalo
No abstract text is available yet for this article.
August 26, 2018: Diagnostic Cytopathology
Xiaorong Zhang, Xianglan Zhu, Jinnan Li, Nian Liu, Qiyuan Li, Xueying Su
Fine-needle aspiration (FNA) is commonly used to evaluate both primary thyroid lesions (PTLs) and secondary thyroid neoplasms (STNs). Although STNs are uncommon, metastases from various primary sites particularly the kidney, lung, and breast have been previously described. Giant cell tumor (GCT) is typically found in the metaphyseal-epiphyseal area of long bones that seldom involves thyroid. The typical cytological feature of GCT on FNA smears is highly cellular dual cell pattern consisting of mononuclear stromal cells and multinucleate osteoclast-like giant cells...
August 26, 2018: Diagnostic Cytopathology
Nishka U Shetty, Josephine O'Connell, Olaronke O Oshilaja, Deepa T Patil, Gary W Procop, Charles D Sturgis
No abstract text is available yet for this article.
August 26, 2018: Diagnostic Cytopathology
Aditi Goyal, Priya Pathak, Pooja Sharma, Sonal Sharma
BACKGROUND: Swellings in the hand and wrist are frequently encountered in clinical practice and fine needle aspiration cytology (FNAC) is used as a primary diagnostic modality in most of them. A wide spectrum of lesions can be encountered at these sites. The aim of this study was to report the prevalence and spectrum of hand and wrist lesions and evaluate the diagnostic role of FNAC. METHODS: All the patients who presented with palpable lesions in the hand or wrist between January 2011 and July 2016 were reviewed, retrospectively...
August 25, 2018: Diagnostic Cytopathology
Debajyoti Chatterjee, Ranjeev Bhagat, Vinisha Bansal, Rajpal Singh Punia, Nitin Gupta
Chondroid neoplasm of parotid gland is extremely rare. Only a few cases of extraskeletal chondroma and one case of chondrosarcoma of parotid gland have been reported in the literature. The cytological features of parotid gland chondroma are not well documented. A 61-year female patient presented with a slow growing left preauricular mass for past 6 years. Computer tomography scan showed a well circumscribed mass in the superficial lobe of left parotid gland. Fine needle aspiration cytology (FNAC) showed uniform chondrocytes embedded in a chondroid matrix, and was diagnosed as pleomorphic adenoma...
August 25, 2018: Diagnostic Cytopathology
P Umasankar, U Lakshmi Priya, Asiq Sideeque
Galactocele is a common lesion occurring during pregnancy or lactation. It is a benign cystic breast lesion containing milk. On Fine Needle Aspiration Cytology, milky fluid is aspirated, and cytology shows paucicellular aspirate with foamy macrophages and occasional apocrine cells in a proteinaceous fluid background. Rarely, the contents of galactocele can crystallize giving rise to an entity of crystallizing galactocele. Crystallizing galactocele is a rare entity, and to the best of our knowledge, less than 10 cases have been reported in the literature...
August 25, 2018: Diagnostic Cytopathology
Min-Sun Jin, Hyebin Lee, Min A Kim, In Ae Park, Chul Lee, Hyoung Jin An, Bobae Shim, Ji Hye Moon, Jae Kyung Won, Han Suk Ryu
BACKGROUND: Although the Papanicolaou (Pap) test is the first-line screening method for cervical cancer, it has low sensitivity for detection of human papillomavirus (HPV)-infected cervical lesion compared to the HPV test. The aims of this study are to determine novel cytomorphologic parameters for HPV infection in patients previously diagnosed as negative for intraepithelial lesion or malignancy (NILM) and to comparatively analyze the detection performance of 3 HPV tests: nested PCR, the DNA Chip test, and the Liquid Beads Microarray (LBMA) assay...
August 25, 2018: Diagnostic Cytopathology
Abha Goyal, Reem Z Sharaiha, Susan A Alperstein, Momin T Siddiqui
BACKGROUND: Bile duct brushing (BDB) cytology, for the characterization of bile duct strictures, can be challenging to interpret when associated with a stent. Our study aims to identify the cytologic criteria for the diagnosis of adenocarcinoma in BDBs in the presence of a stent. METHODS: A database search (January 2010-December 2015) identified three groups of BDBs-negative with stent, malignant with stent, malignant without stent. All malignant cases had histologic and/or cytologic evidence of malignancy within 1 month of the brushing sample...
August 25, 2018: Diagnostic Cytopathology
Shikha Aggarwal, Ruchita Tyagi, Pavneet Kaur Selhi, Avantika Garg, Ajit Sood, Neena Sood
Sarcina ventriculi is a rare gram-positive, anaerobic bacteria, associated with delayed gastric emptying. We report a case of a 45-year-old lady, who presented with features of gastric outlet obstruction, and coinfection of S. ventriculi and Candida was detected on examining gastric brushings and biopsy. S. ventriculi is identified by its peculiar configuration in the form of tetrads and octets. Coexistence of S. ventriculi with other organisms is highly unusual.
July 27, 2018: Diagnostic Cytopathology
Sule Canberk, Diana Montezuma, Ozlem Aydın, Mehmet Polat Demirhas, Barkın Denizci, Meryem Akbas, Can Caliskan, Fatma Tokat, Umit Ince, Fernando Schmitt
BACKGROUND: In 2016, the Papanicolaou Society of Cytopathology (PSC) issued a new classification scheme for respiratory cytology. We aim to evaluate our samples according to this classification and to assess risk of malignancy and diagnostic yield of different cytological modalities. METHODS: Respiratory specimens (sputum, bronchial wash/brush, BAL and FNA) obtained between 2007 and 2016 were reclassified according to PSC guidelines. Risk of malignancy for each diagnostic category was determined...
July 27, 2018: Diagnostic Cytopathology
Stylianos A Michaelides, George D Bablekos, Avgerinos-Romanos S Michailidis, Antonis Analitis, Paraskevi X Kapatsis, Eleni Ellina, Nicoletta Maounis
OBJECTIVES: Given that cytology of adenocarcinoma-induced pleural effusions has a high diagnostic yield, we have comparatively evaluated the cytological information of smears during biphasic sampling of pleural fluid in patients with metastatic pleural adenocarcinoma from various primary sites. METHODS: We studied 25 male and 21 female patients, aged 59.4 ±17.2 years (mean ± SD) with unilateral malignant effusion of varying magnitude due to confirmed adenocarcinoma from various primary sites...
July 25, 2018: Diagnostic Cytopathology
Recep Nigdelioglu, John Biemer, Stefan E Pambuccian
No abstract text is available yet for this article.
July 25, 2018: Diagnostic Cytopathology
Masumi Osugi, Kosei Kinoshita, Atsuro Sugita, Katsumi Kito, Toshiharu Maeda
BACKGROUND: We performed p63 immunostaining to detect myoepithelial cells on BD SurePath liquid-based cytology (LBC) slides and examined whether this improved the diagnostic accuracy in breast fine-needle aspiration cytology (FNAC). METHODS: We examined the diagnostic accuracy using the LBC-p63 immunostaining slides of 298 lesions obtained from July 2010 to August 2016. RESULTS: We defined the cutoff values for malignancy as follows: (1) the percentage of p63+ cluster was <30%, (2) the percentage of p63+ single cells in cell clusters was <3%, (3) the number of p63+ single cells in the background was <20 when the total number of the cell clusters was <100, or the number was <120 when the total number was ≥100...
July 25, 2018: Diagnostic Cytopathology
Tarek Eldessouki, Kelly Hanley, Fatima Hamadeh, Olaronke O Oshilaja, Charles D Sturgis
The Revised fourth Edition World Health Organization (WHO) Classification of Tumors of Hematopoietic and Lymphoid Tissues suggests novel categories, including "high grade B-cell lymphoma with MYC and BCL2 and BCL6 gene rearrangements." These diseases are known colloquially as "double hit" and "triple hit" lymphomas. The "first-hit" in these cases is the harboring of a MYC rearrangement. Concurrent derangements of BCL2 and BCL6 can be the "second-hit" or "third-hit...
July 25, 2018: Diagnostic Cytopathology
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