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Diagnostic Cytopathology

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https://www.readbyqxmd.com/read/28345284/role-of-fine-needle-aspiration-cytology-in-the-diagnosis-of-a-rare-case-of-a-poorly-differentiated-synovial-sarcoma-with-rhabdoid-features-including-treatment-implications
#1
Bharat Rekhi, Omshree Shetty, Mukta Ramadwar, Venkatesh Rangarajan, Jyoti Bajpai
Synovial sarcoma is a high-grade, soft tissue sarcoma that is relatively chemosensitive. Its exact diagnosis is crucial, including differentiation from its closest diagnostic mimic, ie, Ewing sarcoma, in view of different treatment options, including chemotherapy regimens, for both these tumors. A 15-year-old girl presented with a recurrent soft tissue mass in her right popliteal region, which was diagnosed as Ewing sarcoma, based on positive immunoexpression of MIC2/CD99, Fli1 and negative expression of LCA and desmin...
March 27, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28342244/the-utility-of-pap-cell-block-preparations-with-liqui-prep%C3%A2-cell-pellets-to-clarify-the-cytological-diagnosis-of-atypical-squamous-cells-of-undetermined-significance-and-atypical-glandular-cells
#2
Nicholas B George, Jashua Haddad Baldassari, Digno A Pérez Taveras, María José Fernández, María Concepción Robledo
OBJECTIVE: Atypical squamous cells of undetermined significance (ASCUS) and atypical glandular cells (AGC) reflect cellular abnormalities insufficient for clear diagnosis. We used cell pellets obtained from liquid-based cytology (LBC) to prepare cell blocks (CB) and clarify the initial diagnosis of ASCUS and AGC. STUDY DESIGN: A total of 393 CBs with initial diagnosis of ASCUS or AGC were processed. Of those, 305 of the ASCUS and 20 of the AGC had adequate specimens...
March 24, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28332339/sonographic-and-cytologic-differences-of-niftp-from-infiltrative-or-invasive-encapsulated-follicular-variant-of-papillary-thyroid-carcinoma-a-review-of-179-cases
#3
REVIEW
Grace C H Yang, Karen O Fried, Theresa Scognamiglio
We reclassified 179 cases of the follicular variant (FV) of papillary thyroid carcinoma (PTC) into 72 (40.2%) noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP), 37 (20.7%) encapsulated FVPTC with invasion (EFVPTC), and 70 (39.1%) infiltrative FVPTC (IFVPTC) without a capsule. In the NIFTP group, 5.6% cytology were hypercellular and the remainder low to moderate cellularity. PTC nuclei were absent in 18%, focally present in 37.5%, and diffusely present in 44.4%. In the EFVPTC group, 8...
March 22, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28332304/sclerosing-polycystic-adenosis-a-rare-tumor-misdiagnosed-as-retention-cyst-on-fine-needle-aspiration-cytology
#4
Shilpi, Fuzail Ahmad Ansari, Shalini Bahadur, Akshi Katyal, Aastha Narula, Namrata Nargotra, Sompal Singh
Sclerosing polycystic adenosis (SPA) is a rare benign neoplasm of the salivary gland which resembles the fibrocystic disease of the breast clinically as well as morphologically. This entity has varied morphological presentation on fine needle aspiration. Only a few case reports and occasional case series are found in the literature describing its cytology. Here we are presenting a case of SPA in the parotid gland in a 13-year-old male patient who presented with a slow growing infra-auricular mass since one year without any other symptoms...
March 22, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28322032/fine-needle-aspiration-of-metastatic-melanoma-presenting-as-bilateral-breast-cysts
#5
Casey M Inouye, Ashley Cimino-Mathews, David Eisner, Dorothy L Rosenthal, Christopher J VandenBussche
Melanoma is the second most common non-hematopoietic malignancy after carcinomas to metastasize to the breast and often appears as a well-circumscribed, dense nodule on imaging. Although metastatic lesions presenting as bilateral cysts have been reported, this presentation is not common and may mimic benign breast cysts. We present a challenging case of metastatic melanoma presenting as bilateral breast cysts with spindled cytomorphology in a patient with a history of mammary carcinoma. Discordance between the spindled cytomorphology and the morphology of the core biopsy, which was similar to the patient's primary breast cancer, allowed for entertainment of other tumors and disease processes...
March 20, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28318112/diagnostic-dilemmas-and-pitfalls-in-thinprep-%C3%A2-cytology-of-breast-fine-needle-aspiration-biopsy-report-of-six-cases-with-histological-correlates
#6
Jose Victor Scarpa Carniello, Fresia Pareja, Maria Laureana Santos-Zabala, Marcia Edelweiss
Fine needle aspirations (FNA) of the breast for primary diagnoses have become less popular in the USA and are usually performed for lesions with low or extremely high clinical suspicion. They are also performed for lesions in close proximity to a breast implant. Liquid-based cytological preparations, such as ThinPrep(®) (TP), provide a practical alternative to clinicians who are performing FNA. Using a selection of cases that represent challenging diagnoses, we describe common diagnostic pitfalls of breast FNA that are specifically associated with this preparation...
March 20, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28296246/assessment-of-oral-cytological-features-in-smokers-and-nonsmokers-after-application-of-toluidine-blue
#7
Majid Sharbatdaran, Hamid Abbaszadeh, Sepideh Siadati, Mohammad Ranaee, Karimollah Hajian-Tilaki, Mahdieh Rajabi-Moghaddam
INTRODUCTION: Smoking is the most important etiologic factor of oral cancer. Exfoliative cytology is the best method for early detection of oral cancer. Toluidine blue staining is used for detection of oral premalignant and malignant lesions. The aim of this study was to enhance the accuracy of oral exfoliative cytology in evaluating dysplastic features using toluidine blue staining. METHODS AND MATERIALS: This clinical trials study was performed on 60 male smokers and nonsmokers without clinically oral lesion...
March 10, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28276158/an-adolescent-with-large-cell-calcifying-sertoli-cell-tumor-of-the-testis-and-undiagnosed-carney-complex-a-case-report
#8
Frida Rosenblum, Richard Gabriel Koenig, Fady M Mikhail, John R Porterfield, Jeffrey W Nix, Isam-Eldin A Eltoum
Carney Complex (CNC) is a rare autosomal dominant condition with characteristic clinical presentation, tumor development, and unique genetic mutation. We present a unique case and literature review of CNC in which two neoplasms characteristic of this complex were initially diagnosed through cytological fine needle aspirate specimens, leading to the identification of CNC, with subsequent surgical and cytogenetic confirmation. Diagn. Cytopathol. 2017. © 2017 Wiley Periodicals, Inc.
March 9, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28267302/cytomorphology-of-metastatic-pituitary-carcinoma-to-the-bone
#9
Christopher M Chandler, Xiaoqi Lin
Metastatic pituitary carcinoma to bone is rare. In this report, we present a case of a 59-year-old female with recurrent pituitary adenoma of the sparsely granulated somatotroph subtype with metastasis to a few bony sites 10 years later. Needle core biopsy (NCB) with touch preparations was performed on a 5 mm lesion in left ilium. Diff-Quik stained NCB touch preparation slides showed a few loosely cohesive epithelial polygonal cells that were arranged in nests or acini, or singly, had scant vacuolated cytoplasm and eccentrically located round nuclei (plasmacytoid) with slight nuclear pleomorphism, fine granular chromatin, conspicuous nucleoli, and smooth nuclear membrane...
March 7, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28267274/utility-of-touch-imprint-cytology-in-the-preoperative-diagnosis-of-malignancy-in-low-resource-setting
#10
Amit Kumar Adhya, Ranjan Mohanty
BACKGROUND: Touch imprint cytology (TIC) is a very rapid, cheap, and easy method used for the rapid evaluation of intraoperative specimens and post mortem cases. This study aims to evaluate its utility in preoperative diagnosis of cancer. METHODS: A total of 476 cases of suspected malignancy of different sites and different histological subtypes were studied. TIC was obtained in all the biopsies and the cytological findings were correlated with the corresponding biopsy diagnosis to evaluate the diagnostic accuracy...
March 7, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28262005/parotid-or-carotid-misled-by-site
#11
Ruchita Tyagi, Manish Munjal, Pavneet Kaur, Harpreet Kaur, Neena Sood
We present an interesting scenario where a 64 years old male presented with a long standing painless, infra-auricular swelling, which had progressively increased in size. Based on the site, the clinical impression was of a salivary gland lesion and FNAC was performed. The smears were unusually cellular and had necrotic background. The cytological diagnosis was a cystic neoplasm of salivary gland, possibly mucoepidermoid carcinoma. Warthin's tumor was also kept in differential. However, the radiological investigations, which were made available after the FNAC report were conflicting with cytological diagnosis of a malignancy and were characteristic of a carotid body tumor, generally a benign neoplasm...
March 6, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28262004/update-on-the-cytologic-features-of-papillary-thyroid-carcinoma-variants
#12
REVIEW
Marc Pusztaszeri, Manon Auger
Papillary thyroid cancer (PTC), which accounts for 85-90% of all thyroid cancers, is generally an indolent tumor with long term survival rates >95%. A reliable definitive diagnosis of PTC is usually straightforward in fine needle aspirates of conventional PTC whenever the characteristic papillary and/or flat honeycomb sheet-like architecture and the typical nuclear features of chromatin pallor, nuclear enlargement, crowding, grooves and pseudoinclusions are encountered. Conventional PTC, however, has diminished in relative frequency as compared to PTC variants, especially the noninvasive follicular variant of PTC, an indolent tumor which has recently been reclassified as "noninvasive follicular thyroid neoplasm with papillary-like nuclear features" (NIFTP)...
March 6, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28261999/cytological-evaluation-by-fine-needle-aspiration-biopsy-of-incidental-focal-increased-fluorodeoxyglucose-uptake-in-thyroid-on-positron-emission-tomography-scan
#13
Yanchun Li, Min Cui, Nami Azar, Dean Nakamoto, Claire W Michael
BACKGROUND: With the increased use of whole body fluorodeoxyglucose positron emission tomography (PET) scan for staging/restaging or primary diagnosis of neoplasia, thyroid incidentalomas have become more common. The limited reports of PET-positive thyroid incidentalomas showed incidence of malignancy ranging from 14 to 66%, and there is discrepancy in terms of the diagnostic significance of the standard uptake value (SUV) value. METHODS: This is a retrospective study of 20 PET incidentalomas which had cytological evaluation from October 2009 to February 2015 at a tertiary care university medical center, M:F = 8:12...
March 6, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28261993/carcinoma-ex-pleomorphic-adenoma-a-diagnostic-challenge-on-cytology
#14
Kanika Singh, Charu Agarwal, Mukta Pujani, Pragya Verma, Varsha Chauhan
Carcinoma ex pleomorphic adenoma (Ca ex PA) is a malignant neoplasm arising from primary or recurrent benign pleomorphic adenoma. It is rare with an annual incidence rate of 0.17 tumors per million. Histopathology remains the gold standard for the diagnosis of Ca ex PA, with only a handful of cases reported on cytology. In our case a 66-year-old male presented with the right parotid mass for 5 years rapidly increasing for the last 3 months. Fine needle aspiration cytology (FNAC) smears showed malignant tumor cells in clusters along with benign myoepithelial cells in chondromyxoid background...
March 6, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28261978/the-cellularity-yield-of-three-different-22-gauge-endoscopic-ultrasound-fine-needle-aspiration-needles
#15
Mohamed O Othman, Mohamed M Abdelfatah, Osvaldo Padilla, Maha Hussinat, Sherif Elhanafi, Mohamed Eloliby, Alireza Torabi, Nawar Hakim, Darius A Boman
BACKGROUND: Endoscopic ultrasound (EUS) fine needle aspiration (FNA) is an integral part in the diagnosis of pancreatic, intestinal and extra-intestinal masses or lesions. There is no clear data on the superiority of the core biopsy needle over standard 22-gauge needles. The aim of this study is to prospectively compare the cellularity yield of three commonly used 22-gauge FNA needles available in the US market. METHODS: This is a prospective, randomized study comparing the cellularity yield of three commercially available EUS needles (two standard FNA needles and core biopsy needle)...
March 6, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28261927/challenging-differential-diagnosis-of-an-extra-adrenal-paraganglioma-the-role-of-fine-needle-aspiration-cytology
#16
Ioannis Ntanasis-Stathopoulos, Diamantis I Tsilimigras, Eirini Klapsinou, Dimitra Daskalopoulou, Simona Vaida, Niki Arnogiannaki, Charitini Salla
Paragangliomas are rare neoplasms that arise from neural crest cells of the autonomous system. Herein, we present a case of a 37-year-old patient with a history of retroperitoneal paraganglioma and tuberculous infection presenting with a paraganglioma of the neck that was initially misdiagnosed as metastatic tumor originating from the lungs. Cytological features from fine needle aspiration and immunocytochemistry pointed to the right diagnosis. However, distinguishing between primary and metastatic site of a paraganglioma can be very challenging due to the overlapping features of these entities...
March 6, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28251831/cytologic-findings-of-mammary-analogue-secretory-carcinoma-arising-in-the-thyroid
#17
Paula A Rodríguez-Urrego, Snjezana Dogan, Oscar Lin
Mammary analogue secretory carcinoma (MASC) of the salivary gland, first described by Skálová et al in 2010, is a tumor that morphologically and genetically resembles breast secretory carcinoma harboring ETV6-NTRK3 fusion gene. To date, only seven cases of primary thyroid MASC have been described. The overall findings are similar to those seen in the salivary gland counterpart including the ETV6-NTRK3 fusion gene. This is the second report describing the cytologic features of MASC at this primary location, which also showed a classical type papillary carcinoma component...
March 2, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28247571/lower-respiratory-tract-viral-infections-diagnostic-role-of-exfoliative-cytology
#18
REVIEW
Rafael Martínez-Girón, Liron Pantanowitz
Viral lower respiratory tract infections (VLRTI) remain one of the most common causes of morbidity and mortality worldwide. For many years, the diagnosis of VLRTI was based on laboratory techniques such as viral isolation in cell culture, antigen detection by direct fluorescent antibody staining, and rapid enzyme immunoassay. Radiological imaging and morphology also play an important role in diagnosing these infections. Exfoliative cytology provides a simple, rapid, inexpensive, and valuable means to diagnose and manage VLRTI...
March 1, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28247550/bacterial-vaginosis-and-inflammatory-response-showed-association-with-severity-of-cervical-neoplasia-in-hpv-positive-women
#19
LETTER
Juçara Maria de Castro-Sobrinho, Silvia Helena Rabelo-Santos, Rosane Ribeiro Fugueiredo-Alves, Sophie Derchain, Luis Otávio Z Sarian, Denise R Pitta, Elisabete A Campos, Luiz Carlos Zeferino
No abstract text is available yet for this article.
March 1, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28247516/introduction-of-liquid-based-cytology-and-human-papillomavirus-testing-in-cervical-cancer-screening-in-luxembourg
#20
Ardashel Latsuzbaia, Gaëtan Hebette, Marc Fischer, Marc Arbyn, Steven Weyers, Philippe Vielh, Fernando Schmitt, Joël Mossong
BACKGROUND: In 2014, liquid-based cytology with HPV triage replaced conventional cytology. The aim of our study was to compare conventional and liquid-based cytology (LBC), estimate the prevalence of abnormal cervical cytology and high risk HPV (hrHPV) infection and their correlation, among screened women in Luxembourg. METHODS: Between the first January 2013 and 31st December 2015, 315,868 cervical samples from 150,815 women (mean age 42.2 years) were investigated by the national cytology laboratory...
March 1, 2017: Diagnostic Cytopathology
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