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Diagnostic Cytopathology

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https://www.readbyqxmd.com/read/29143491/fine-needle-aspiration-evaluation-of-pancreatic-lymphoma-a-retrospective-study-of-25-cases-in-a-single-institution
#1
Jiehao Zhou, Howard Wu, Jingmei Lin, Xiaoyan Wang, Shanxiang Zhang, Harvey Cramer, Shaoxiong Chen
BACKGROUND: Accurate diagnosis of pancreatic lymphoma is crucial for clinical management. We evaluate the role of fine-needle aspiration (FNA) in the diagnosis of pancreatic lymphoma with the aid of flow cytometry and/or immunohistochemistry on the cell block. METHODS: Cases of pancreatic lymphoma were collected by searching our pathology laboratory information system over a period of 16 years. The clinical findings, cytologic features, and immunophenotypic results were reviewed...
November 16, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29131558/cytologic-findings-of-an-adult-rhabdomyoma-in-the-parapharyngeal-space-a-report-of-a-case-and-review-of-the-literature
#2
Josephine Kamtai Dermawan, Erika Doxtader, Deborah J Chute, Maria Luisa Policarpio-Nicolas
Adult extracardiac rhabdomyomas are rare benign mesenchymal tumor arising from skeletal muscle. While they are often located in the larynx and pharynx, the incidence in the parapharyngeal area is extremely rare with only 1 documented cytology case report to date. We report a case of an adult extracardiac rhabdomyoma in the parapharyngeal space diagnosed cytologically with subsequent histologic confirmation. The patient is a 57-year-old man with history of weight loss, hematuria, dysphagia, and airway encroachment...
November 12, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29131539/molecular-testing-on-endobronchial-ultrasound-ebus-fine-needle-aspirates-fna-impact-of-triage
#3
Simon Sung, John P Crapanzano, David DiBardino, David Swinarski, William A Bulman, Anjali Saqi
BACKGROUND: Endobronchial ultrasound (EBUS)-guided fine needle aspiration (FNA) is performed to diagnose and stage lung cancer. Multiple studies have described the value of Rapid On-Site Evaluation (ROSE), but often the emphasis is upon diagnosis than adequacy for molecular testing (MT). The aim was to identify variable(s), especially cytology-related, that can improve MT. METHODS: A search for EBUS-FNAs with ROSE was conducted for lung adenocarcinomas or when this diagnosis could not be excluded...
November 12, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29124912/metastatic-medullary-thyroid-carcinoma-or-calcitonin-secreting-carcinoid-tumor-of-lung-a-diagnostic-dilemma-in-a-patient-with-lung-mass-and-thyroid-nodule
#4
Shifteh Vahidi, Jimmie Stewart, Khalid Amin, Emilian Racila, Faqian Li
Calcitonin-secreting neuroendocrine tumors are rare and have been reported in literature as case reports or case series in various organs including lung, pancreas, larynx, bladder, and ovary. These tumors have similar cytologic features and immunohistochemical profile to medullary thyroid carcinoma and thus it is difficult to distinguish them, especially when calcitonin-secreting neuroendocrine tumors are intermediate or higher grade and there is a mass lesion in the thyroid gland. Here, we report a rare case of calcitonin secreting atypical carcinoid tumor of the lung in a patient with thyroid nodule...
November 10, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29124909/ameloblastic-carcinoma-with-metastasis-to-the-parotid-gland
#5
Caitlin Alexander, Zahra Maleki
No abstract text is available yet for this article.
November 10, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29124900/unsatisfactory-exfoliative-anal-cytology-samples-15-year-experience-with-histologic-cytologic-and-molecular-follow-up
#6
Ruba Khattab, Emily McMeekin, Alan J Taege, James M Hekman, Jennifer A Brainard, Dawn Underwood, Gary W Procop, Charles D Sturgis
BACKGROUND: The incidence of anal carcinoma has risen in recent decades. Exfoliative cytology screening of selected high risk patients is performed in many centers. Unsatisfactory cytology results are frustrating to patients, clinicians, and laboratorians. The aim of this study is to ascertain outcomes of patients with non-diagnostic anal cytology. METHODS: A retrospective review of anal cytology testing performed at the Cleveland Clinic between 01/01/2001 and 12/31/2015 was performed...
November 10, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29115061/carcinoma-showing-thymus-like-elements-report-of-a-case-with-egfr-t790m-mutation
#7
Madhu Rajeshwari, Varsha Singh, Aruna Nambirajan, Asit Ranjan Mridha, Deepali Jain
Carcinoma showing thymus-like differentiation of the thyroid (CASTLE) is a rare tumor involving the thyroid and perithyroidal soft tissues. It shares morphological, immunohistochemical and molecular similarities with thymic carcinomas. Due to its relatively better prognosis, it needs differentiation from other primary and metastatic tumors of this region. A 40-year-old lady presented with a gradually progressive anterior neck swelling for one year. Imaging showed bulky right and left lobes of thyroid along with a solid soft tissue mass in the pretracheal region...
November 8, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29115040/telecytology-is-it-possible-with-smartphone-images
#8
Davut Sahin, Uguray Payam Hacisalihoglu, Saime Hale Kirimlioglu
INTRODUCTION: This study aimed to discuss smartphone usage in telecytology and determine intraobserver concordance between microscopic cytopathological diagnoses and diagnoses derived via static smartphone images. METHODS: The study was conducted with 172 cytologic material. A pathologist captured static images of the cytology slides from the ocular lens of a microscope using a smartphone. The images were transferred via WhatsApp® to a cytopathologist working in another center who made all the microscopic cytopathological diagnoses 5-27 months ago...
November 8, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29115014/impact-of-variant-microscopic-interpretation-of-the-ucyt-immunocytological-urine-test-for-the-detection-of-bladder-cancer
#9
Susanne Deininger, Tilman Todenhöfer, Jörg Hennenlotter, Valentina Gerber, Jennifer Schwarz, Jens Bedke, Christian Schwentner, Arnulf Stenzl, Steffen Rausch
BACKGROUND: Urinary marker tests for bladder cancer (BC) detection and surveillance represent a desirable approach to diagnosis and follow-up. The SCIMEDX uCyt+ assay detects antigens expressed by BC cells (mucin glycoprotein and carcinoembryonic antigen) using green and red fluorescence and is interpreted according to specific manufacturer's recommendations. In the present study, we evaluated divergent approaches of numeric and morphological analysis of uCyt+ to generate a rationale for alternative test interpretation strategies...
November 8, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29105378/letter-to-the-editor-a-rare-case-of-microfilaria-in-ascitic-fluid
#10
LETTER
Ojas Gupta, Sunny Bhardwaj, Pranab Dey
No abstract text is available yet for this article.
November 4, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29105363/cytomorphologic-features-of-metastatic-endometrioid-carcinoma-by-fine-needle-aspiration
#11
Daniel N Johnson, Julieta E Barroeta, Tatjana Antic, Ricardo R Lastra
BACKGROUND: Although metastatic disease is commonly seen in high grade carcinomas of gynecologic origin, it also occurs in low to intermediate grade endometrioid carcinomas (LGEMCAs), and may even be the primary presentation of disease. Tissue confirmation is necessary to guide therapy, but performing biopsies might not always be feasible or practical. In such instances, fine needle aspiration (FNA) is a safe and efficient alternative. No comprehensive series describing the cytomorphologic features of metastatic LGEMCA on FNA samples has been published...
November 4, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29087044/primary-diagnosis-of-angiosarcoma-by-fine-needle-aspiration-lessons-learned-from-3-cases
#12
M Lepe, Y Hui, L Pisharodi, M Canepa
Angiosarcomas are rare malignancies arising from cells of endothelial origin and are aggressive sarcomas that can occur in any anatomic site. They are reported to have predilection for the scalp, extremities and breasts. The incidence of these tumors is increasing, which has been suggested to be attributable to the growing use of radiotherapy to treat breast and other malignancies. There is currently limited literature describing the primary cytologic diagnosis of angiosarcoma on fine needle aspirate material...
October 31, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29076659/cytological-findings-of-ros1-rearranged-lung-adenocarcinoma
#13
Naoto Kuroda, Hiroyuki Tamiya, Kimiko Nakatani, Haruna Ide, Yukari Wada, Kaori Yasuoka, Masahiko Ohara, Keiko Mizuno, Kenji Yorita, Kengo Takeuchi
ROS1-rearranged lung adenocarcinoma has been recently identified. We report a case of ROS1-rearranged lung adenocarcinoma with special emphasis on cytological findings. Here, we report a case of young woman with ROS1-rearranged lung adenocarcinoma diagnosed by cytology and discuss the clinical, cytological, and molecular findings. Cytologically, the tumor consisted of small tight clusters of cells with high nuclear/cytoplasmic ratio. Nuclei were enlarged and small nucleoli were occasionally observed. Signet-ring cells were focally identified...
October 27, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29076658/fine-needle-aspiration-cytology-of-hepatic-metastases-of-neuroendocrine-tumors-a-20-year-retrospective-single-institutional-study
#14
Omer A M Saeed, Harvey Cramer, Xiaoyan Wang, Howard H Wu
BACKGROUND: Fine needle aspiration (FNA) is considered an excellent technique for documenting metastatic neuroendocrine tumors (NETs). This study aims to evaluate the accuracy of FNA in diagnosing metastatic NETs to the liver and determining the grade and origin of these metastases. METHODS: Our laboratory information system was searched from 1997 to 2016 to identify all cases of metastatic NETs to the liver that were sampled by FNA. The cytopathology and surgical pathology reports as well as the patients' electronic medical records were reviewed...
October 27, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29076656/cytological-challenges-in-the-diagnosis-of-intrathyroidal-parathyroid-carcinoma-a-case-report-and-review-of-literature
#15
REVIEW
Meera Balakrishnan, Smiley Annie George, Sayed Hashim Rajab, Issam M Francis, Kusum Kapila
Parathyroid carcinoma is an uncommon malignancy and the probability of an intrathyroidal location is low. Fine needle aspirations (FNA) of these presumably "thyroid nodules" can lead to misinterpretation because of the similarities in cytological features of parathyroid and thyroid lesions. Despite limitations, USG guided FNA cytology remains the first line of investigation. We report a case of intrathyroidal parathyroid carcinoma presenting with hypercalcemia and elevated serum parathormone. Cytological findings attributed it to a possible parathyroid lesion and histopathology revealed a parathyroid carcinoma...
October 27, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29063719/aberrant-single-minded-homolog-1-methylation-as-a-potential-biomarker-for-cervical-cancer
#16
Hyun-Jung Kim, Chan Young Kim, Jinghui Jin, Moon Kyoung Bae, Yun Hee Kim, Woong Ju, Yun Hwan Kim, Seung Cheol Kim
BACKGROUND: The aim of this study is to evaluate the possibility of using the methylation status of single-minded homolog 1 (SIM1) as a diagnostic biomarker for cervical cancer. METHODS: All the patient and normal specimens including the normal cervix (n = 10), cervical cancer tissues (n = 45), blood (n = 45), and cervical brush specimens (n = 110) were retrospectively obtained. Quantitative methylation-specific PCR was performed to detect SIM1 methylation in primary tumors, cervical brush specimens, and plasma circulating cell-free DNA (ccfDNA)...
October 24, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29063707/pulmonary-cryptococcosis-diagnosed-on-a-lung-fine-needle-aspiration
#17
Jing Lu, Elizabeth L Palavecino, Ziyan T Salih
No abstract text is available yet for this article.
October 24, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29048733/cytology-and-high-risk-hpv-testing-in-cervical-cancer-screening-program-outcome-of-3-year-follow-up-in-an-academic-institute
#18
Jack Yang, Fredrick S Nolte, Olga S Chajewski, Kathryn G Lindsey, Patricia M Houser, Jalidsa Pellicier, Qun Wang, Laleh Ehsani
BACKGROUND: Combination of cervical cytology and high-risk human papillomavirus (HR-HPV) testing, co-testing, has been increasingly used in screening cervical cancers. The present study summarized the outcome of co-testing by reviewing 3-year clinical and pathological follow-up information. METHODS: Patients were retrospectively identified via computerized search and were grouped based on the cytologic diagnosis and HR-HPV status as negative for intraepithelial lesion or malignancy (NILM)/HPV-, NILM/HPV+, atypical squamous cells of undetermined significance (ASC-US)/HPV-, ASC-US/HPV+, low grade squamous intraepithelial lesion (LSIL)/HPV-, LSIL/HPV+, atypical squamous cells, cannot exclude high grade squamous intraepithelial lesion (ASC-H)/HPV-, ASC-H/HPV+, high grade squamous intraepithelial lesion (HSIL)/HPV-, and HSIL/HPV+...
October 19, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29048730/bronchial-oncocytosis-an-incidental-finding-in-ultrasound-guided-transbronchial-fine-needle-aspiration-cytology
#19
LETTER
José A Jiménez-Heffernan, Patricia Muñoz-Hernández, Alwalid Freih Fraih
No abstract text is available yet for this article.
October 19, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29048728/cytokeratin7-expression-in-histologic-and-cytologic-specimens-of-cystic-neck-metastasis-from-hpv-positive-squamous-cell-carcinoma-of-the-tonsil-a-case-report
#20
Yong Kyun Cho, Seung Ju Lee, Jeong Joo Woo, Hyekyung Lee, Hojung Lee
The majority of cystic squamous cell carcinomas (SCCs) of the neck have been shown to be metastatic tumors from tonsillar SCCs associated with high-risk human papillomavirus (HR HPV). Recent studies have demonstrated cytokeratin (CK)7 involvement in the development of HPV positive SCC, but no report has been issued on its simultaneous expression in primary tonsillar and metastatic tumor with cystic change. We present a case of HPV positive tonsillar SCC of a 42-year-old male that initially manifested as a cystic neck mass expressing CK7, CK19, and p16 in primary and metastatic tumors...
October 19, 2017: Diagnostic Cytopathology
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