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Diagnostic Cytopathology

Agnieszka Onisko, Marek J Druzdzel, R Marshall Austin
BACKGROUND: In the era of extensive data collection, there is a growing need for a large scale data analysis with tools that can handle many variables in one modeling framework. In this article, we present our recent applications of Bayesian network modeling to pathology informatics. METHODS: Bayesian networks (BNs) are probabilistic graphical models that represent domain knowledge and allow investigators to process this knowledge following sound rules of probability theory...
November 19, 2018: Diagnostic Cytopathology
Aparna Harbhajanka, Satyapal Chahar, Claire W Michael
BACKGROUND: Although the incidence of glandular cell abnormalities (GCA) on cervical cytology is low, the clinical and histologic findings are often significant. A combined diagnosis of squamous intraepithelial lesion (SIL) and GCA indicates concern for either two distinct lesions or single entity. The goal of this study is to evaluate the outcome of the diagnosis of GCA alone or in combination with squamous abnormality (SqA). METHODS: From January 2012-June 2017, our laboratory processed 162 088 ThinPrep Pap tests...
November 19, 2018: Diagnostic Cytopathology
İbrahim Karaca, Mustafa Öztürk, Cihan Comba, Gökhan Demirayak, Şakir Vokan Erdoğan, Murat Hoşgören, İsa Aykut Özdemir
OBJECTIVES: According to the American Society of Colposcopy and Cervical Pathology (ASCCP), cervical cytology patients who test positive for atypical squamous cells of undetermined significance (ASCUS) and the human papilloma virus (HPV) positive are recommended to undergo colposcopies. This study compared the colposcopic biopsy evaluation results of patients with positive cervical cytology results for ASCUS and HPV with regards to their HPV genotypes. METHODS: This study included 179 patients who underwent cervical cancer screening tests between June 2015 and June 2017 and whose results displayed positive cervical cervical cytology results for ASCUS and HPV...
November 16, 2018: Diagnostic Cytopathology
Neetu Pandey, Sumaira Qayoom, Mala Sagar, Madhu Mati Goel
No abstract text is available yet for this article.
November 16, 2018: Diagnostic Cytopathology
Valentina Sangiorgio, Lorenzo Daniele, Teresa Gallo, Rodolfo Rocca, Cristina Fava, Paola Campisi, Giovanni De Rosa
Perivascular epithelioid cell tumors (PEComas) are rare mesenchymal tumors that can affect any part of the body. They can be sporadic or arise in the setting of tuberous sclerosis (TSC). In this article, we report a series of three hepatic and two pancreatic PEComas diagnosed preoperatively with ultrasound-guided fine needle aspiration (FNA). All patients were female (age range 28-70), had no personal history of TSC and presented with a single, localized painless mass. Rapid on-site evaluation (ROSE) of cytologic samples was performed for all cases to evaluate for cellular content and adequacy of specimens...
November 12, 2018: Diagnostic Cytopathology
Yuichi Kinoshita, Mayumi Inaba, Tadao K Kobayashi, Shin-Ichi Murata
BACKGROUND: Intraoperative diagnosis is an essential tool for the rapid diagnostic assessment of clinically critical head and neck lesions. Thus, we assumed that a combination of frozen section histological and cytological diagnoses may be preferable. Here, we investigated a relatively new method called liquid-based cytology of rinsed tissue fragments (LBC-RTF) and compared this method with intraoperative histological diagnosis. METHODS: We used 68 tissue biopsies (9 brains, 8 lymph nodes, 22 salivary glands, and 29 thyroid samples)...
November 12, 2018: Diagnostic Cytopathology
Kyriaki Savvidou, Aglaia Dimitrakopoulou, Nikolitsa Kafasi, Konstantinos Konstantopoulos, Theodore Vassilakopoulos, Maria Angelopoulou, Marina Siakantaris, Penelope Korkolopoulou, Panagiotis Kanavaros, Panagiota Mikou
BACKGROUND: We investigated serous effusions occurring during the course of an already known hematologic neoplasia or as a first manifestation of it. We correlated cytology results with flow cytometry results, when available. In the absence of flow cytometry, our correlation was based on clinical follow up information obtained retrospectively. We evaluated our results in relation to the data of the literature and we considered some new suggestions for the improvement of cytology service...
November 12, 2018: Diagnostic Cytopathology
Liron Pantanowitz, Lester J Layfield, Zubair W Baloch
No abstract text is available yet for this article.
November 12, 2018: Diagnostic Cytopathology
Mukta Pujani, Varsha Chauhan, Charu Agarwal, Sujata Raychaudhuri, Kanika Singh
BACKGROUND: Fine needle aspiration cytology (FNAC) is the first line investigation for pre-operative diagnosis of salivary gland lesions, but due to its inherent limitations remains a challenge for the cytopathologists. The recently proposed international risk stratification scheme, the Milan System for Reporting Salivary Gland Cytology (MSRSGC) aims to promote and standardise the communication between cytopathologist and clinician thereby improving patient care. METHODS: A retrospective study of all salivary gland cytology cases was performed over a 3-year period, reviewed by pathologists and categorised into 1 of the 6 diagnostic categories according to MSRSGC, namely, non-diagnostic, non-neoplastic, atypia of undetermined significance (AUS), benign neoplasm, and salivary gland neoplasm of undetermined significance (SUMP), suspicious for malignancy (SFM), and malignant neoplasm...
November 12, 2018: Diagnostic Cytopathology
Teresa McHale, N Paul Ohori, Kathy M Cieply, Carol Sherer, Sheldon I Bastacky
BACKGROUND: We examine the performance of cytology and FISH in the detection of urothelial carcinoma (UC), and explore the reasons for discrepant results, and potential clinical implications. METHODS: Urine samples from 89 patients were prospectively collected for simultaneous cytology and UroVysion FISH, and results correlated with concurrent biopsies and/or clinical or histologic follow-up data. Corresponding tissue biopsies, where available, were also evaluated by FISH...
November 12, 2018: Diagnostic Cytopathology
Masayuki Shintaku, Hiromi Taniguchi, Yoshihiro Yamamoto, Fumihiko Kono, Masahiro Sumitomo
Serous tubal intraepithelial carcinoma (STIC) has attracted attention as a precursor lesion of high-grade serous carcinoma (HGSC) of the ovary. We report the rare case of a woman in whom adenocarcinoma cells were detected in cervical smears and demonstrated to be derived from STIC in the fimbria. The patient was a 48-year-old woman, in whom cervical smears contained adenocarcinoma cells, but cervical conization did not reveal adenocarcinoma. Because the post-conization smears again demonstrated adenocarcinoma cells, hysterectomy with bilateral salpingectomy was performed 16 months after the first detection of adenocarcinoma cells in cervical smears...
October 30, 2018: Diagnostic Cytopathology
Victoria Northrup, Behram Cenk Acar, Mohammad Hossain, Matthew R Acker, Eric Manuel, Tarek Rahmeh
BACKGROUND: Urinary cytology is routinely used in the diagnosis of urothelial neoplasms, with good sensitivity for high-grade urothelial carcinoma (HGUC) but less so for low-grade urothelial neoplasm (LGUN). There is significant interobserver and interinstitutional variability, especially for the atypical category. The Paris system for reporting urinary cytology (TPS) was introduced to better define the various categories, especially atypical cytology. METHODS: We retrospectively reviewed 630 atypia of undetermined significance (AUS) cases and reclassified them based on TPS...
October 30, 2018: Diagnostic Cytopathology
Kunio Mochizuki, Yuki Hanai, Kumiko Nakazawa, Shiori Murata, Kazuki Kasai, Naoko Mochizuki, Ippei Tahara, Tetsuo Kondo
IgG4-related disease (IgG4-RD) can affect various organs, and the pancreas and salivary gland are representative examples. We report a rare case of IgG4-RD of the paratestis. A 74-year-old man presented with left scrotal swelling. Scrotopuncture drainage and cytology confirmed a clear, yellow retention liquid (130 mL) with many small, similar lymphocytes and a few plasmacytes. Many lymphoid cells were immunopositive for CD3 on a cell block section, indicating that a predominant type of lymphoid cells was T cell...
October 30, 2018: Diagnostic Cytopathology
Archana George Vallonthaiel, Rajni Yadav, Deepali Jain, Sandeep R Mathur, V K Iyer
BACKGROUND: Mucinous adenocarcinoma (MC) of gallbladder is a rare histological subtype of gallbladder carcinoma (CaGB) which presents at an advanced stage and is associated with a poor prognosis compared to the conventional CaGB. This variant has been described mostly as reports or series, except for a single detailed histological and immunohistochemical analysis. Till date, there are no studies describing the cytomorphology of MC in detail. Hence, we undertook this study to analyse the cytomorphological features of MC...
October 30, 2018: Diagnostic Cytopathology
Sahar J Farahani, Zubair Baloch
INTRODUCTION: Fine needle aspiration (FNA) has been widely utilized in establishing the nature of salivary gland lesions and guiding the clinical management. This study aimed to determine the accuracy of FNA in detecting salivary gland neoplasms and malignancies, employing the "Milan System for Reporting Salivary Gland Cytopathology" (MSRSGC). METHOD: A systematic search was conducted. The data on FNA and histologic diagnosis were extracted and categorized based on the MSRSGC and risk of malignancy (ROM) was calculated...
October 29, 2018: Diagnostic Cytopathology
Tracy R Shachner, Stuart E Van Meter
Metastatic cancer involving the uterine cervix is exceedingly rare, and accounts for less than 1% of cancer deaths. The cervix is an uncommon location for metastatic lesions due to its limited blood supply and fibrous stroma and metastatic melanoma of the cervix is particularly infrequent. To the best of our knowledge and literature review, there have only been nine reported cases in the literature of metastatic melanoma involving the uterine cervix that were diagnosed via cervicovaginal Pap smears, including the case being reported in this paper...
October 24, 2018: Diagnostic Cytopathology
Banhisikha Kanjilal, Moupali Ghosh, Avijit Mitra, Suvrendu Kar, Janki Bisht, Ram Narayan Das, Uttara Chatterjee
Adrenocortical carcinoma (ACC) is a rare tumour, which sometimes affects pediatric age group. Fine needle aspiration cytology (FNAC) is a rarely performed technique in adrenal cortical tumours. There is sparse literature available describing the cytological findings of ACCs in children. Here we describe the cytological findings of 2 cases of ACCs in children. The first case describes the FNAC findings in a 4 year old girl who presented with a large abdominal mass. The second case narrates the intra-operative imprint cytology findings in a 2-year-old boy who came with precocious puberty...
October 24, 2018: Diagnostic Cytopathology
Isin Ureyen, Tayfun Toptas, Aysel Uysal
BACKGROUND: In the present study, we primarily aimed to correlate the colposcopy results of patients with human papillomavirus (HPV) positivity and abnormal cervical screening results. Secondarily, we attempted to define the role of endocervical curettage (ECC) in the colposcopic evaluation of patients who had normal cytology and HPV16, which is the most carcinogenic HPV type. METHODS: This was a retrospective study analyzing the data of patients who had colposcopies between January 2015 and May 2016 in the Gynecological Oncology clinic of a single tertiary center...
October 24, 2018: Diagnostic Cytopathology
A Barrigón, S Ziadi, M Jacot-Guillarmod, S Da Silva, M Dumont, I Raineri, M Bongiovanni
Nabothian cysts are common, benign findings of the squamocolumnar junction of the adult cervix. These cysts are filled with mucus and can also contain proteinaceous material, neutrophils, or neutrophil debris. Nabothian cysts can be broken by the spatula during smear taking, may stick to the brush and be smeared onto slides in conventional cytology or dissolved in the preserving solution for liquid-based cytology (LBC) preparations. The granular content of Nabothian cysts may be mistaken for the tumor diathesis (TD) pattern associated with invasive carcinoma...
October 24, 2018: Diagnostic Cytopathology
Neelam Sood
Nipple discharge (ND) either in the presence or in the absence of underlying mass is a very uncommon presentation in males and its bloody nature is still rarer. ND cytology in males has not been reported much in the literature. Spontaneous and expressed ND, however, can be very useful in establishing the diagnosis. Two males with bloody ND, one, without any palpable mass and another with underlying mass, were evaluated on ND cytology. The presence of loose papillaroid clusters and cell sheets with mild atypia was seen in ND smears itself in case 1...
October 24, 2018: Diagnostic Cytopathology
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