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Diagnostic Cytopathology

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https://www.readbyqxmd.com/read/28084690/cytologic-features-of-pleomorphic-xanthoastrocytoma-who-grade-ii-a-comparative-study-with-glioblastoma
#1
José A Jiménez-Heffernan, Alwalid Freih Fraih, Federico Álvarez, Carmen Bárcena, Cesar Corbacho
Pleomorphic xanthoastrocytoma (PXA) is a WHO grade II astrocytic tumor of children and young adults. It is characterized by pleomorphic, atypical astrocytes. Atypia is so remarkable, that PXA can be easily misdiagnosed as malignant glioma. If confused with a high-grade glioma the neurosurgeon may not proceed with a complete resection. Therefore, a specific recognition during intraoperative consultation is particularly important. We describe four cases of PXA evaluated during intraoperative procedures. Findings were compared with those of 22 glioblastomas...
January 13, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28084685/fungal-spores-and-fruiting-bodies-in-cervicovaginal-smears-contaminant-or-infection
#2
Hema Kini, Jyoti R Kini, Ethel Suman, Sharada Rai
BACKGROUND: Contaminants from various sources are curious findings in cervicovaginal smears and pose diagnostic challenges especially when they need to be distinguished from pathogens. Candidiasis is the most frequently encountered fungal infection but fungal contaminants are relatively common. Detection of fruiting bodies and spores of Aspergillus species is uncommon and may represent either a true infection or contamination. This study was undertaken to evaluate the presence of fungal spores, hyphae, and fruiting bodies in routine cervical smears and distinguish a true infection from contamination...
January 13, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28024119/accuracy-of-international-ultrasound-risk-stratification-systems-in-thyroid-lesions-cytologically-classified-as-indeterminate
#3
Pierpaolo Trimboli, Franco Fulciniti, Valentina Zilioli, Luca Ceriani, Luca Giovanella
BACKGROUND: Eminent international societies have published their thyroid ultrasound risk stratification system (US-RSS) to give a friendly tool for thyroidologists. In particular, American Thyroid Association (ATA), American Association Clinical Endocrinologists/American College of Endocrinologists and Associazione Medici Endocrinologi (AACE/ACE/AME), British Thyroid Association (BTA), and Thyroid Imaging Reporting and Data System (TIRADS) are often adopted for clinical practice. The reliability of these US-RSS has not been evaluated in discriminating cancers from benignancy in nodules with indeterminate FNA...
December 26, 2016: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28024116/mulberry-cells-in-the-thyroid-warthin-finkeldey-like-cells-in-hashimoto-thyroiditis-associated-lymphoma
#4
Razvan Lapadat, Moon Woo Nam, Swati Mehrotra, Milind Velankar, Stefan E Pambuccian
Warthin-Finkeldey type giant cells were first described in autopsies performed on young children who died during the highly lethal measles epidemic in Palermo during the winter of 1908. The cells had 8-15 nuclei without identifiable cytoplasm within the germinal centers of lymphoid organs resembling megakaryocytes. We describe a case of Hashimoto thyroiditis with an enlarging substernal throid mass. The resection specimen contained many Warthin-Finkeldey-Like Cells (WFLC) in an extranodal marginal zone lymphoma (MALT type) with focal transformation to diffuse large B-cell lymphoma...
December 26, 2016: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28024111/pleomorphic-rhabdomyosarcoma-arising-in-the-anterior-mediastinum-a-case-report-with-cytological-features-of-imprint-and-liquid-based-cytology-specimens
#5
Yoshimi Nishijima, Junko Hirato, Toshio Fukuda
We herein report the cytological features of a very rare case of pleomorphic rhabdomyosarcoma arising in the anterior mediastinum on imprint and liquid-based cytology (LBC) specimens. A 58-year-old man had an approximately 10-cm tumor in the anterior mediastinum as shown on computed tomography. Thymectomy with complete resection of the left lung was performed. The fresh cut surface of the tumor was used to prepare imprint and LBC specimens. The imprint specimens showed four types of tumor cells dispersed on a background of hemorrhage, necrosis, and mucus...
December 26, 2016: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28024110/the-importance-of-ezh2-and-moc-31-expression-in-the-differential-diagnosis-of-benign-and-malignant-effusions
#6
Canan Sadullahoglu, Deniz Nart, Ali Veral
BACKGROUND: All malignant tumors may spread throughout the pleural, peritoneal, and pericardial cavities. The presence of tumor cells in serosal fluid is a poor prognostic indicator. It may be difficult to differentiate nuclear atypia of mesothelial cells due to injury of serosal surfaces from mesothelioma or malignant epithelial tumor cells. Epithelial and mesothelial immunohistochemical markers can be used in such conditions. The aim of this study was to evaluate the expression of two immunohistochemical markers (MOC-31 and EZH2) in serosal effusions...
December 26, 2016: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/27933740/fine-needle-aspiration-in-the-diagnosis-and-classification-of-hepatoblastoma-analysis-of-21-new-cases
#7
Tatjana Vlajnic, Hervé J Brisse, Isabelle Aerts, Paul Fréneaux, Cécile Cellier, Monique Fabre, Jerzy Klijanienko
BACKGROUND: Diagnosis of hepatoblastoma (HBL) is based on characteristic clinical and radiological presentation, young age and marked elevation of serum α-fetoprotein (aFP). Fine needle aspiration (FNA) technique is successfully used in the diagnosis of hepatoblastoma. To evaluate the value of FNA in the diagnosis and subtyping of HBL, we report our experience correlated to histological sections (core needle biopsy, CNB). METHODS: From 1991 to 2015, 21 cases from 20 patients were cytologically diagnosed as HBL...
December 9, 2016: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/27902883/metastatic-carotid-body-paraganglioma-of-lungs-and-lymph-nodes-unsuspected-diagnosis-on-ebus-tbna
#8
Kalpana Kumari, Deepali Jain, Rohit Kumar, Anant Mohan, Rakesh Kumar
Paragangliomas are tumors that originate from the extra-adrenal chromaffin and nonchromaffin cells of neural crest origin. Lymph node metastases are common, while distant metastases to lung, liver, and bone are rare events and usually occur in the presence of a long standing clinically evident primary tumor. Primary diagnosis of paraganglioma at a metastatic site without a known primary is a diagnostic challenge. We report a case of an adult woman with incidentally detected metastasis to bilateral lungs from an occult carotid body paraganglioma, which presented a cytopathological diagnostic dilemma on EBUS-TBNA from paratracheal lymph nodes...
November 30, 2016: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/27902879/imprint-cytologic-and-immunocytochemical-findings-of-sclerosing-pneumocytoma
#9
Naoto Kuroda, Masahiko Ohara, Keiko Mizuno, Kenji Yorita
To the best of our knowledge, there is no description on immunocytochemical study of sclerosing pneumocytoma (SP) using a cell transfer method. In this article, we report imprint cytological and immunocytochemical findings of SP. Three cases of SP possessing both imprint cytological and histological materials were examined. All tumors showed well-defined margin grossly. On microscopic examination, the tumor consisted of surface and stromal round cells. Cytologically, surface and stromal round cells showed fragments or clusters of papillary configuration with low N/C ratio and cell clusters of small to medium-sized cells with high N/C ration...
November 30, 2016: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/27900846/plasmablastic-lymphoma-mimicking-carcinomatosis-a-case-report-and-review-of-the-literature
#10
Andrea M Olofson, Eric Y Loo, Paul A Hill, Xiaoying Liu
First identified as a distinct disease entity in HIV-positive patients, plasmablastic lymphoma is a rare aggressive disease which arises predominantly in men and is associated with immunodeficiency of all causes. Although its exact etiology is poorly understood, Epstein-Barr virus infection and MYC gene aberrations have been implicated in its development in both HIV-positive and HIV-negative patients. The disease typically involves extranodal sites with a predilection for the oral cavity but may occur in other locations...
November 30, 2016: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/27888664/ebv-associated-but-hhv8-unrelated-double-hit-effusion-based-lymphoma
#11
Bo-Jung Chen, David Yen-Ting Chen, Chun-Chi Kuo, Shih-Sung Chuang
Effusion-based lymphoma is a rare and unique type of large B-cell lymphoma presenting in effusion without a mass lesion. It shares many clinicopathological features with primary effusion lymphoma (PEL), but is distinct from PEL by the absence of HHV8 association. Double hit lymphoma (DHL) is an aggressive B-cell lymphoma, defined by concurrent rearrangement of MYC and BCL2 or BCL6. DHL often presents as lymphadenopathy or an extranodal mass, but rarely occurs in effusion. Here we report a 61-year-old male with alcoholic cirrhosis presenting as massive ascites and left pleural effusion...
November 26, 2016: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/27888661/use-of-vimentin-immunocytochemical-staining-for-evaluation-of-atypical-cells-in-voided-urine-samples
#12
Margareta Strojan Fležar, Irena Srebotnik-Kirbiš, Helena Gutnik
BACKGROUND: Cytomorphology of exfoliated atypical reactive/repair renal tubular cells (RRTC) can resemble atypical urothelial cells thus suggesting a differential diagnostic question of urothelial neoplasia in urinary cytology. Vimentin expression has been shown in RRTC and used for differentiation from atypical urothelial cells. METHODS: The institutional computer database was searched for urinary cytology cases with vimentin immunocytochemical staining (2008-2012)...
November 26, 2016: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/27888660/strongyloides-in-cerebrospinal-fluid
#13
Ya Xu, Neda Zarrin-Khameh
No abstract text is available yet for this article.
November 26, 2016: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/27888659/intraoperative-diagnosis-of-hydatid-cyst-of-the-ovary-masquerading-as-tumor
#14
Pavneet Kaur Selhi, Sumit Grover, Vikram Narang, Aminder Singh, Neena Sood, Sunil Juneja
Hydatid disease, caused by the larval stage of Echinococcus granulosus, is found most commonly in the liver and lungs, but no organ is immune. The ovarian involvement is often secondary to a cyst's dissemination localized in a different site. Occasionally, the cyst enlarges, thus mimicking an ovarian tumor. Patients with hydatid cysts at unusual locations present with atypical presentations and pose a diagnostic dilemma. A high index of suspicion is required in order to make a correct diagnosis pre-operatively to prevent spillage of the cyst contents during surgery...
November 26, 2016: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/27888658/a-case-of-composite-classical-and-nodular-lymphocyte-predominant-hodgkin-lymphoma-with-progression-to-diffuse-large-b-cell-non-hodgkin-lymphoma-diagnostic-difficulty-in-fine-needle-aspiration-cytology
#15
Dilip K Das, Zafar A Sheikh, Mariam H Al-Shama'a, Bency John, Abdulla M S Alawi, Thamradeen A Junaid
A small percentage of nodular lymphocytic predominant Hodgkin lymphoma (NLPHL) progresses to diffuse large B-cell lymphoma (DLBCL). There have also been rare reports of gray zone lymphoma with features intermediate between classical Hodgkin lymphoma (CHL) and DLBCL. We report a very rare case of composite lymphoma (CHL and NLPHL) progressing to DLBCL, and highlight the diagnostic difficulty faced during its fine-needle aspiration (FNA) cytology diagnosis. A 65-year-old woman presented with a right axillary swelling which was subjected to FNA cytology...
November 26, 2016: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/27879064/clear-cell-carcinoma-first-suspected-in-pap-smear-the-value-of-neutrophil-cannibalism-by-tumor-cells
#16
LETTER
Badr AbdullGaffar
No abstract text is available yet for this article.
November 23, 2016: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/27879059/squash-cytology-of-tanycytic-ependymoma-a-report-of-two-cases
#17
Priyanka Maity Chaudhuri, Shubhamitra Chaudhuri, Debashis Chakrabarty, Sandip Chatterjee, Chhanda Datta, Manoj Kumar Chaudhuri, Uttara Chatterjee
Tanycytic ependymoma is a rare variant of ependymoma which has a predilection for the spinal cord. It is a WHO grade II tumour with favourable outcome. Although squash cytology of ependymoma is well described, there is sparse literature available on squash cytomorphology of tanycytic variant. Here we present two cases of squash cytology of tanycytic ependymoma. In the first case the diagnosis of tanycytic ependymoma was considered. However, in the second case a diagnosis of usual ependymoma was offered. Subsequently histopathology confirmed tanycytic nature in both the cases...
November 23, 2016: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/27860444/cytological-findings-and-bcl10-expression-in-pancreatic-acinar-cell-carcinoma-a-case-report
#18
Akinobu Ohno, Yuichiro Sato, Eriko Nakamura, Hiroshi Noguchi, Takako Tokumitsu, Masahide Hiyoshi, Atsushi Nanashima, Yujiro Asada
BCL10 was recently demonstrated to be a biomarker for pancreatic acinar cell carcinoma, but whether altered BCL10 expression can be detected in cell block specimens is unclear. Here, we report a pancreatic acinar cell carcinoma with cytological findings that showed BCL10 expression in a cell block. A 72-year-old man presented with a pancreatic tumor and underwent endoscopic ultrasound-fine needle aspiration (EUS-FNA) with additional passes performed for cell block preparation. The EUS-FNA cytology showed loose cohesive clusters with focal acinar- or gland-like-structures and prominent nucleoli...
November 17, 2016: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/27863187/cytology-of-primary-vaginal-melanoma-an-unusual-report-on-fine-needle-aspiration
#19
Poojan Agarwal, Manju Kaushal
Primary malignant melanoma of the vagina is an extremely uncommon malignancy comprising of less than 10% malignancies of the female genital tract and 0.3% of all melanomas. Melanoblasts are neural crest derivatives and are notorious for causing primary cutaneous neoplasms. However, they involve virtually every organ of the body including eye, intestines and ocular mucosa, probably due to aberrancies in cell migration. Vagina is a rare site and primary melanoma of the vagina occurs in postmenopausal women with vaginal discharge, bleeding, or mass as common presenting complaints...
November 11, 2016: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/27863182/corpora-amylacea-and-molluscum-contagiosum-on-a-cervical-pap-smear
#20
Kaila Buckley, Zaibo Li
When evaluating a Papanicolaou (Pap) smear, the cytology of the squamous epithelial cells is of utmost importance. This is what cytopathologists use to render a diagnosis, ranging from normal to atypical squamous cells of undetermined significance (ASCUS) to high grade squamous intraepithelial lesions, or even squamous cell carcinoma. However, occasionally the pathologist will run into microscopic noncellular material as in our case, such as corpora amylacea on the slides, or even uncommon viral inclusions such as Molluscum contagiosum (MCV)...
November 8, 2016: Diagnostic Cytopathology
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