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Diagnostic Cytopathology

journal
https://www.readbyqxmd.com/read/28816034/cerebrospinal-fluid-cytology-in-nonmalignant-aseptic-meningeal-disorders
#1
REVIEW
Rafael Martínez-Girón, Liron Pantanowitz
Cerebrospinal fluid cytology examination is a common and reliable primary and/or complementary procedure for the diagnosis of central nervous system (CNS) disorders. This review provides an update of aseptic meningeal disorders that may be encountered in cytopathology practice. The article covers the cytological findings and helpful ancillary studies needed of nonmalignant aseptic CNS disorders such as viral, bacterial, fungal and parasitic infections, and other noninfectious diseases, such as Mollaret´s meningitis (recurrent benign lymphocytic meningitis), Guillain-Barré syndrome, multiple Sclerosis, subarachnoid haemorrhage, and drug-induced disorders...
August 16, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28802095/the-diagnostic-utility-of-merkel-cell-polyomavirus-immunohistochemistry-in-a-fine-needle-aspirate-of-metastatic-merkel-cell-carcinoma-of-unknown-primary-to-the-pancreas
#2
Long Li, Kyle Molberg, Naga Cheedella, Joel Thibodeaux, Stacy Hinson, Elena Lucas
Merkel cell carcinoma (MCC) is an aggressive skin tumor with a high tendency for metastases. We report a case of MCC initially presenting as axillary and pancreatic metastases. A 33-year-old HIV-positive Hispanic male presented with a history of a rapidly growing axillary mass. A needle core biopsy demonstrated an epithelioid neoplasm composed of small to medium-sized cells with high nuclear-cytoplasmic ratio, nuclear molding, and frequent mitotic figures. A subsequent PET scan revealed a 1.5 cm FDG avid mass in the pancreas...
August 12, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28802094/oncocytic-variant-of-medullary-thyroid-carcinoma-a-rare-tumor-with-numerous-diagnostic-mimics-by-fine-needle-aspiration
#3
Sharon B Sams, Kenneth D Tompkins, Sarah Mayson, Christopher D Raeburn, Sanjana Mehrotra
Oncocytic variant of medullary thyroid carcinoma is rare form of thyroid carcinoma that is easily misdiagnosed on fine needle aspiration specimens due to it is low incidence and cytomorphologic overlap with other more common Hurtle cell lesions. A correct initial diagnosis by fine needle aspiration is imperative as the clinical treatment for medullary carcinoma differs significantly from the mimickers. We present a case of this rare variant tumor that on initial fine needle aspiration was described as a Hurthle cell lesion and was subsequently correctly classified on the resection specimen...
August 12, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28799730/oral-pemphigus-vulgaris-liquid-based-cytological-findings-and-pitfalls
#4
Seiji Kondo, Jiro Kawashima, Katsumi Kobata, Toshihiro Ohgawara, Shiho Tanaka, Kazuki Nabeshima, Toshihiro Kikuta
Pemphigus vulgaris (PV) is a chronic autoimmune bullous disease characterized by the formation of suprabasal cleavage and acantholysis. As this disease almost always affects the oral mucosa, conventional cytological smears of oral lesions can be used for the initial diagnosis of PV. We report two cases of PV that were initially diagnosed based on cytological smears of an oral sample. As atypical squamous cells were present even in the liquid-based cytological (LBC) smears of the oral lesion in these two cases, this ultimately led to the misinterpretation of squamous cell carcinoma...
August 11, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28799728/the-combined-application-of-urinary-liquid-based-cytology-with-fluorescence-in-situ-hybridization-and-p16-ki-67-dual-immunostaining-is-valuable-for-improving-the-early-diagnosis-of-upper-tract-urothelial-carcinomas
#5
Xueqi Sun, Xubin Liu, Meng Xia, Shicong Yang, Lingyan Fei, Mengqi Zhang, Hanyu Ma, Liantang Wang, Shangwu Chen, Li Yu
OBJECTIVES: To evaluate the diagnostic values of urine liquid-based cytology (LBC), fluorescence in situ hybridization (FISH), and p16/Ki-67 dual immunostaining in the detection of upper tract urothelial carcinomas (UTUCs). METHODS: Sixty-one patients with UTUCs were retrospectively analyzed. All patients were diagnosed both by urine cytology and by FISH, and histologically confirmed as UTUCs. Thirty-two patients had been stained with p16/Ki-67 dual labeling. RESULTS: The sensitivities for low-grade UTUCs (LGUTUCs) and high-grade UTUCs (HGUTUCs) were 33...
August 11, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28792123/fine-needle-aspiration-cytology-of-acute-blastomycosis-thyroiditis
#6
Nagarjun Rao, Sherri J Mann
No abstract text is available yet for this article.
August 9, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28772003/case-of-chondroid-syringoma-mimicking-as-nodular-hidradenoma-a-diagnostic-pitfall-on-cytopathology
#7
Bahadur Shalini, Katyal Akshi, Nargotra Namrata, Soni Shilpi, Nain Manupriya
Limited literature is available on the use of fine needle aspiration (FNA) for skin tumors. Awareness of cytological features of these lesions is important to prevent misdiagnosis. A 45-year-old male, presented with slowly growing swelling over the thigh since 4 years. FNA from multiple sites yielded highly cellular smears with a dual cell population consisting of cells with small round nucleus scanty cytoplasm and polygonal cells with moderate to abundant cytoplasm. Extracellular basement membrane like material was also noted...
August 3, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28771986/clinicopathological-significance-of-atypical-glandular-cells-on-cervicovaginal-pap-smears
#8
Mi-Kyung Kim, Yoo Kyung Lee, Sung Ran Hong, Kyung Taek Lim
OBJECTIVE: To evaluate the histologic correlation and clinical significance of atypical glandular cells (AGC) detected on Pap tests. METHODS: Pap tests interpreted as AGC were retrieved from an institutional cytopathology database. The AGC subcategories according to the Bethesda system 2001 include atypical glandular cells, not otherwise specified (AGC-NOS), atypical endometrial cells (AEM), and atypical endocervical cells (AEC). Clinicopathologic variables were collected from medical records retrospectively, and histologic follow-up diagnoses were correlated with AGC subcategories...
August 3, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28755513/cytological-features-of-the-warthin-like-variant-of-salivary-mucoepidermoid-carcinoma
#9
Jen-Fan Hang, Chung H Shum, Syed Z Ali, Justin A Bishop
Warthin-like mucoepidermoid carcinoma is a recently proposed variant of musoepidermoid carcinoma. Histologically, it is characterized by its close resemblance to Warthin tumor, including dense lymphocytic infiltration, flattened intermediate epithelium resembling squamous metaplasia, and cystic change. Given its histologic similarity to Warthin tumor, confirmatory testing for MAML2 rearrangement is often required for this diagnosis. Here we present the first cytologic reports of two 53-year-old female patients with parotid masses...
July 29, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28752676/fine-needle-aspiration-findings-of-a-rare-hematopoietic-neoplasm-presenting-as-obstructive-jaundice
#10
Jessica Tracht, Ali M Ahmed, Frida Rosenblum Donath
A 51-year-old female who presented with obstructive jaundice was found to have masses in the pancreatic head and tail as well as suspicious liver and periaortic masses on imaging. Aspiration cytology of the pancreatic tail mass showed abundant large single cells with vacuolated eosinophilic cytoplasm, marked nuclear pleomorphism, large bizarre irregular nuclei, binucleation, and prominent nucleoli. Numerous cells also showed intracytoplasmic black to brown pigmentation. A cell block was obtained and extensive immunohistochemical staining was performed...
July 27, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28752611/quality-assessment-and-improvement-of-unsatisfactory-liquid-based-cervicovaginal-papanicolaou-smears
#11
Neda Mirzamani, Karen Chau, Oana Rafael, Uday Shergill, Sujata Sajjan, Irina Sumskaya, Cecilia Gimenez, Melissa Klein, Kasturi Das
OBJECTIVES: The quality of cervicovaginal smears determines the success of cytology in screening programs for cervical cancer. Bethesda 2014 revisited the adequacy criteria for atrophic smears and redefined the squamous cell count in the "unsatisfactory" category. In this study, we evaluated the smear quality of Thinprep liquid-based cervicovaginal Papanicolaou cytology slides (TPS) that were previously deemed unsatisfactory, to determine reasons for such categorization. In addition, we attempted to establish the impact of the new adequacy criteria on the rate and management of unsatisfactory diagnosis...
July 27, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28731543/pollen-grains-as-contaminants-in-cytopathology
#12
LETTER
Rafael Martínez-Girón, Cristina Martínez-Torre
No abstract text is available yet for this article.
July 21, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28731534/internal-quality-control-in-an-academic-cytopathology-laboratory-for-the-introduction-of-a-new-reporting-system-for-endometrial-cytology
#13
Niki Margari, Abraham Pouliakis, Dionysios Aninos, Christos Meristoudis, Magdalini Stamataki, Ioannis Panayiotides, Petros Karakitsos
BACKGROUND: To evaluate reproducibility of a reporting system for endometrial cytology. METHODS: Cytologic slides from 49 patients, prepared via liquid based cytology, were blindly examined by five cytopathologists of various experience levels, applying a recently introduced reporting system as previously reported. The agreement among cytopathologists was evaluated via Kappa (κ) statistics and the Kendall's Coefficient of Variation (W); cytologic results were compared with the relevant histologic report...
July 21, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28719046/retinal-pigment-epithelium-adenoma-in-vitreous-fluid-cytology
#14
Sandhya John, Madelyn Lew
Ocular cytology specimens are relatively uncommon, adding to the difficulty of their evaluation by cytopathologists. While melanomas account for a majority of primary intraocular pigmented lesions, other diagnostic considerations must be included in the differential. This brief report highlights a case of a pigmented ocular lesion in a 24-year-old man and key morphologic, immunohistochemical, and clinical differences between melanoma, melanocytoma, choroidal nevus, and retinal pigment epithelium (RPE) adenoma...
July 18, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28699306/strategies-for-building-a-successful-ultrasound-guided-fna-practice-in-department-of-pathology-experience-at-a-university-hospital
#15
Maoxin Wu, Kenneth R Shroyer
INTRODUCTION: Although pathology services focused on fine needle aspiration (FNA) biopsy of superficial palpable masses with on-site cytological evaluation are available in a wide range of clinical and academic settings, the addition of ultrasound (US) guidance into FNA practice by a cytopathologist group can be challenging. An US-FNA service provided by a cytopathologist in the department of Pathology is a relatively new practice in the field of medicine. This report summarizes our experience and strategies in achieving this objective and our successful preliminary results...
July 11, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28695686/imprint-cytology-of-clear-cell-sarcoma-like-tumor-of-the-gastrointestinal-tract-in-the-small-intestine-a-case-report
#16
Takashi Kato, Shin Ichihara, Hiroko Gotoda, Shunji Muraoka, Terufumi Kubo, Shintaro Sugita, Tadashi Hasegawa
Clear cell sarcoma-like tumor of the gastrointestinal tract (CCSLGT) is an extremely rare malignant neoplasm in the digestive tract. Its cytomorphologic features have never previously been reported. Here, we describe a case of CCSLGT, including its cytologic examination findings. A 47-year-old woman presented with a mass in the small intestine, which was resected and sent for imprint cytology. Imprint smears revealed tumor cells with light eosinophilic or clear cytoplasm in a necrotic background. Many of the tumor cells were arranged in a perivascular growth with a pseudopapillary formation, and there were some non-neoplastic osteoclast-like giant cells...
July 11, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28685997/calcified-curschmann-s-spirals-and-microliths-in-sputum-smears-from-a-case-of-pulmonary-alveolar-microlithiasis
#17
Rafael Martínez-Girón, Santiago Martínez-Torre
No abstract text is available yet for this article.
July 7, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28681573/monomorphic-epitheliotropic-intestinal-t-cell-lymphoma-in-pleural-effusion-a-case-report
#18
F Antoniadou, A Dimitrakopoulou, P M Voutsinas, K Vrettou, I Vlahadami, M Voulgarelis, P Korkolopoulou, N Kafasi, P Mikou
Dissemination of lymphomas in serous effusions is quite common. Cytology aims to contribute in the clinical management of haematologic patients, providing an accurate and rapid diagnosis. Ancillary techniques such as immunocytochemistry and flow cytometry are essential to classify the lymphoma entity. Comprehensive awareness of the clinical picture and previous histologic documentation are essential for a lymphomatous effusion diagnosis. We report an unusual case of monomorphic epitheliotropic intestinal T-cell lymphoma, formerly known as enteropathy associated T-cell lymphoma (EATL) type II, spreading in the pleural cavity...
July 5, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28670850/cystic-major-salivary-gland-lesions-utilizing-fine-needle-aspiration-to-optimize-the-clinical-management-of-a-broad-and-diverse-differential-diagnosis
#19
Derek B Allison, Austin M McCuiston, Satomi Kawamoto, David W Eisele, Justin A Bishop, Zahra Maleki
INTRODUCTION: The use of fine-needle aspiration (FNA) cytology for the preoperative evaluation of salivary gland lesions is an accepted but, currently, nonstandardized practice. More specifically, cystic major salivary gland lesions are relatively rare and can be very challenging to diagnose on FNA due to low cellularity and an incredibly broad differential diagnosis. The purpose of this study was to investigate the diagnostic utility of preoperative FNA cytology for cystic major salivary gland lesions...
July 3, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28670843/poorly-differentiated-vaginal-adenocarcinoma-with-aggressive-behavior-pap-smear-findings
#20
José Eleutério, Francisca Margalene Medeiros de Freitas, Denise Nunes Oliveira, David Freitas Moreira, Mirley Sângela Pessoa
Vaginal carcinoma is a rare condition. In this report, we describe a case of a poorly differentiated aggressive adenocarcinoma in a woman with a three month history of vaginal bleeding and a negative Pap smear done six months prior to her consultation. Specular examination showed a normal cervix, but there was a bleeding ulcer (2 cm in diameter) in the upper third of the vagina. Cytology revealed poorly differentiated atypical cells, and the biopsy established a diagnosis of vaginal adenocarcinoma with little differentiation...
July 3, 2017: Diagnostic Cytopathology
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