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Diagnostic Cytopathology

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https://www.readbyqxmd.com/read/29318761/suitability-of-the-cellienttm-cell-block-method-for-diagnosing-soft-tissue-and-bone-tumors
#1
W Song, B M van Hemel, A J H Suurmeijer
BACKGROUND: The diagnosis of tumors of soft tissue and bone (STB) heavily relies on histological biopsies, whereas cytology is not widely used. CellientTM cell blocks often contain small tissue fragments. In addition to Hematoxylin and Eosin (H&E) interpretation of histological features, immunohistochemistry (IHC) can be applied after optimization of protocols. The objective of this retrospective study was to see whether this cytological technique allowed us to make a precise diagnosis of STB tumors...
January 10, 2018: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29316379/reactive-histiocytic-proliferation-in-the-pleural-fluid-mimicking-metastatic-signet-ring-adenocarcinoma
#2
Fatima Mir, Anam Naumaan, Hussein Alnajar, Arlen Brickman, Vijaya Reddy, Ji-Weon Park, Paolo Gattuso
Reactive nodular and diffuse histiocytic proliferations of mesothelial and non-mesothelial lined sites have been sporadically reported in the literature. However, there is no cytologic literature describing this process. We report a case of reactive histiocytic proliferation mimicking a metastatic signet ring adenocarcinoma in pleural fluid from a 33-year-old white male. Ancillary studies such as immunohistochemistry should be used to elucidate the cell of origin and avoid diagnostic errors.
January 8, 2018: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29316321/the-role-of-peritoneal-washings-in-the-diagnosis-of-endometriosis
#3
Richard L Cantley, Lorene Yoxtheimer, Stacy Molnar
Endometriosis, the presence of endometrial tissue outside the uterine corpus, is a common finding in reproductive age women. It is classically diagnosed based on the presence of at least two of the following elements: endometrial glands, endometrial stroma, and hemosiderin-laden macrophages (HLMs). Although a common finding in surgical pathology specimens at the time of gynecologic surgery, there is little literature on the role of pelvic washings in diagnosing endometriosis. Our study aimed to examine the characteristics of endometriosis in pelvic washings at the time of gynecologic surgery...
January 8, 2018: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29316304/the-paris-system-for-reporting-urinary-cytology-improves-correlation-with-surgical-pathology-biopsy-diagnoses-of-the-lower-urinary-tract
#4
Elizabeth C Bertsch, Momin T Siddiqui, Carla L Ellis
INTRODUCTION: The current study seeks to compare both the original diagnoses (OD) and the updated Paris system diagnoses (PD) of urinary cytology specimens to the corresponding surgical pathology (biopsy) diagnoses (SD) to determine which diagnostic paradigm (OD vs PD) has a stronger correlation to the SD. DESIGN: 56 cases from 34 patients that had a malignant SD associated with a corresponding cytology specimen from the same location within up to 90 days of the biopsy procedure were selected...
January 8, 2018: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29285892/cytopathologic-features-of-papillary-glioneuronal-tumor
#5
Erika E Doxtader, Charles D Sturgis
No abstract text is available yet for this article.
December 29, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29280339/letter-to-the-editor-uncommon-cells-in-cerebrospinal-fluid-cytology
#6
LETTER
Vani Bharani, Rajesh Kumar, Manish Rohilla, Pranab Dey
No abstract text is available yet for this article.
December 27, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29280335/amyloidosis-diagnosed-in-cytology-specimen-of-pleural-effusion-a-case-report
#7
Rashmi Manur, Ihab Lamzabi
Amyloidosis is a rare condition resulting from extracellular deposition of amyloid, a fibrillary material derived from various precursor proteins. Involvement of the pleura by amyloidosis is a rare but serious complication. Pleural amyloidosis is primarily diagnosed by identifying amyloid deposition by histology on pleural biopsy specimens. Hereby, we report a case of systemic amyloidosis where we were able to identify amyloid in a pleural effusion specimen sent for cytopathology evaluation. A 59-year-old male with newly diagnosed multiple myeloma and systemic amyloidosis underwent therapeutic thoracentesis...
December 27, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29280334/retroperitoneal-ectopic-brain-case-report-and-literature-review
#8
Cristina Díaz Del Arco, Luis Ortega Medina, Issa Subhi-Issa Ahmad
Heterotopic neural tissue (HNT) has been identified in many sites. In our literature review, we have found only two cases of HNT located in the retroperitoneum. As far as we know, cytological features of HNT have not been described. We here report a case of retroperitoneal HNT diagnosed by fine-needle aspiration (FNA) cytology and subsequent resection. Our patient was a male infant born at 26 weeks' gestation. A retroperitoneal solid-cystic lesion measuring 3.8 cm was identified by abdominal ultrasound. FNA was performed and cytology showed highly cellular smears with single cells and masses of fibrillary material...
December 27, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29280331/cytological-features-in-eight-patients-with-alk-rearranged-lung-cancer
#9
Naoto Kuroda, Masahiko Ohara, Yukari Wada, Kaori Yasuoka, Keiko Mizuno, Kenji Yorita, Chiho Obayashi, Kengo Takeuchi
BACKGROUND: ALK-rearranged lung cancer has been recently identified. Although signet-ring cell morphology and mucinous cribriform pattern are considered to be characteristic of ALK-rearranged lung cancer. Some studies have also suggested cytological features. METHODS: This study investigated cytological features of ALK-rearranged lung cancer in eight patients. RESULTS: Cytologically, the tumor cell group varied from isolated to large clusters...
December 27, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29280329/endoscopic-ultrasound-guided-fine-needle-aspiration-what-variables-influence-diagnostic-yield
#10
Sambit K Mohanty, Dinesh Pradhan, Shivani Sharma, Anurag Sharma, Niharika Patnaik, Martin Feuerman, Robert Bonasara, Adrienne Boyd, David Friedel, Stavros Stavropoulos, Mala Gupta
BACKGROUND: Endoscopic ultrasound (EUS) guided fine-needle aspiration (FNA) plays an important role in the diagnosis of various lesions. We sought to determine factors that influence the diagnostic yield of EUS-FNA, specifically, the presence of a cytopathologist, FNA site, and the endoscopist's skill. METHODS: The data on cytopathologist's availability, duration of procedure, number of passes made, and diagnostic material for cell block (CB) preparation was collected over an 18 months period...
December 27, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29266871/artificial-neural-network-model-to-distinguish-follicular-adenoma-from-follicular-carcinoma-on-fine-needle-aspiration-of-thyroid
#11
Rajiv Savala, Pranab Dey, Nalini Gupta
BACKGROUND: To distinguish follicular adenoma (FA) and follicular carcinoma (FC) of thyroid in fine needle aspiration cytology (FNAC) is a challenging problem. AIMS AND OBJECTIVES: In this article, we attempted to build an artificial neural network (ANN) model from the cytological and morphometric features of the FNAC smears of thyroid to distinguish FA from FC. MATERIAL AND METHODS: The cytological features and morphometric analysis were done on the FNAC smears of histology proven cases of FA (26) and FC (31)...
December 20, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29243411/randomized-crossover-trial-comparing-eus-guided-fine-needle-aspiration-with-eus-guided-fine-needle-biopsy-for-gastric-subepithelial-tumors
#12
Tomohisa Iwai, Mitsuhiro Kida, Hiroshi Imaizumi, Shiro Miyazawa, Kosuke Okuwaki, Hiroshi Yamauchi, Toru Kaneko, Rikiya Hasegawa, Eiji Miyata, Wasaburo Koizumi
AIM: The purpose of this study is to compare the diagnostic yield of endoscopic ultrasound (EUS)-guided fine-needle aspiration (EUS-FNA) and EUS-guided fine-needle biopsy (EUS-FNB) for gastric subepithelial tumors (SET). METHODS: Patients diagnosed SET derived from fourth layer of the stomach were prospectively enrolled and randomly assigned to undergo both EUS-FNA using standard needle and EUS-FNB using a core biopsy needle alternatively to the same lesion a total of four times per session...
December 15, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29239140/acquired-myospherulosis-secondary-to-gluteal-augmentation-on-fine-needle-aspiration-cytology-a-diagnostic-challenge
#13
Susan Alperstein, Thomas Dilcher, Kartik Viswanathan, Rema A Rao, Momin T Siddiqui, Tamara Giorgadze
A 30-year-old female presented with a three-month history of a multilocular cystic lesion over the lumbosacral spine. Fine-needle aspiration biopsy (FNA) of the lesion was performed at an outside institution, and a cytologic diagnosis, suspicious for chordoma, was rendered. The patient presented for surgical consultation at our institution. Repeat FNA demonstrated an unusual fat-like material. Upon further inquiry, the patient provided a recent history of gluteal contour improvement with fibroadipose tissue implants...
December 14, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29230975/negative-pap-tests-in-women-with-high-grade-cervical-lesions-on-follow-up-biopsies-contributing-factors-and-role-of-human-papillomavirus-genotyping
#14
Steven Goodman, Roxanne R Mody, Donna Coffey, Blythe K Gorman, Eric Luna, Donna Armylagos, Mary R Schwartz, Dina R Mody, Yimin Ge
BACKGROUND: Previous studies have indicated that negative Papanicolaou (Pap) tests can precede high-grade cervical lesions (HGCL) on biopsy. This study aims to determine the contributing factors for cytologic discrepancy and the potential role of human papilloma virus (HPV) testing in risk evaluation of women with negative Pap tests. METHODS: Of 42,797 Pap tests interpreted as negative for intraepithelial lesion or malignancy (NILM) from March 1, 2013 to December 30, 2014, 426 had available HPV testing and follow-up biopsy...
December 12, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29230974/diagnostic-yield-and-accuracy-of-a-new-cytology-brush-design-compared-to-standard-brush-cytology-for-evaluation-of-biliary-strictures
#15
Jeffrey S Bank, Benjamin L Witt, Linda J Taylor, Douglas G Adler
BACKGROUND: The sensitivity of brush cytology for biliary strictures has typically been low, usually 30%-60%. We compared the cellular yield and diagnostic accuracy using a new cytology brush (n = 16) versus standard biliary brushings (n = 16) in 32 patients who underwent endoscopic retrograde cholangiopancreatography (ERCP) with brushings for evaluation of a biliary stricture for malignancy. METHODS: We performed retrospective chart reviews of 16 consecutive ERCPs with brushings performed for the cytologic evaluation of a biliary stricture for malignancy using the new cytology brush between January 2016 and February 2017 at our institution...
December 12, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29227044/utility-of-core-biopsy-with-concurrent-rose-fna-in-the-diagnosis-of-pancreatic-tumor-does-the-biopsy-add-any-diagnostic-benefit
#16
Lei Yan, Kenji Ikemura, Ji-Weon Park
BACKGROUND: Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) and endoscopic ultrasound-guided core-needle biopsy (EUS-CNB) are widely used for diagnosis of pancreatic tumors. The aim of our study was to compare the diagnostic performance of ROSE EUS-FNA and EUS-CNB for diagnosis of pancreatic malignancy during the same EUS. METHODS: Patients who underwent both FNA and CNB during the same EUS for pancreatic solid lesion were reviewed retrospectively...
December 11, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29218797/lymphoepithelioma-like-carcinoma-of-the-uterine-cervix-cytomorphologic-features-and-diagnostic-pitfalls-by-liquid-based-cytology
#17
Isaac Lloyd, Barbara Chadwick
Lymphoepithelioma-like carcinoma (LELC) is a rare variant of cervical squamous cell carcinoma with unclear HPV and EBV association. Due to the accompanying and often obscuring lymphocytic inflammation, malignant cells may be difficult to recognize on cytologic samples and can mimic several more common benign and atypical cervical lesions. In this case report, we describe the cytomorphologic findings of LELC by liquid-based cytology in a 59-year-old Caucasian woman who was positive for high risk HPV but had no visible cervical lesions...
December 8, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29205961/her2-her3-positive-metastatic-salivary-duct-carcinoma-in-the-pleural-effusion-a-case-report
#18
Kazuya Murata, Akihiko Kawahara, Takeharu Ono, Yorihiko Takase, Hideyuki Abe, Yoshiki Naito, Jun Akiba
Salivary duct carcinoma (SDC) is an aggressive form of salivary gland tumor, and SDC patients tend to be older men, more commonly in advanced stage with a poorer prognosis. Although the cytological characteristics of SDC on fine-needle aspiration cytology have been well-described at the primary site, they have not been explored in metastasis. Here we reported a case of HER2/HER3-positive metastatic SDC in the lung and pleural effusion. The patient was a man in his 50s who had undergone extended total parotidectomy in 2008...
December 4, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29193882/giant-cell-tumor-of-temporomandibular-joint-presenting-as-a-parotid-tumor-challenges-in-the-accurate-subclassification-of-giant-cell-tumors-in-an-unusual-location
#19
Rongqin Ren, Sandra Mueller, Adele O Kraft, Celeste N Powers
Fine needle aspiration is frequently used as the initial diagnostic procedure in the work-up of head and neck lesions, including soft tissue masses and salivary gland neoplasms. Giant cell tumors (GCTs), both osseous and extraosseous, are benign tumors that occur, albeit rarely, in the head and neck region. Extraosseous GCTs may be further classified based on their tissue of origin and specific anatomic location. Regardless of location, giant cell tumors are morphologically similar and share cytologic and histologic diagnostic criteria...
November 30, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29193839/implementing-noninvasive-follicular-thyroid-neoplasm-with-papillary-like-nuclear-features-may-potentially-impact-the-risk-of-malignancy-for-thyroid-nodules-categorized-as-aus-flus-and-fn-sfn
#20
Weihong Li, Andrew Sciallis, Madelyn Lew, Judy Pang, Xin Jing
BACKGROUND: Noninvasive encapsulated follicular variant of papillary thyroid carcinoma (PTC) has recently been reclassified as noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP). Implementation of the new terminology may alter the implied risk of malignancy (ROM) across the six categories of The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC). METHODS: The study cohort consisted of thyroid fine needle aspiration (FNA) cases which were assessed between January 2011 and June 2016 and led to surgical resections...
November 30, 2017: Diagnostic Cytopathology
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