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Diagnostic Cytopathology

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https://www.readbyqxmd.com/read/28449420/cytological-features-of-warthin-like-papillary-thyroid-carcinoma-a-case-report-with-review-of-previous-cytology-cases
#1
Archana George Vallonthaiel, Shipra Agarwal, Deepali Jain, Rajni Yadav, Nishikant A Damle
Warthin-like papillary thyroid carcinoma (WLPTC) is a rare morphological variant of papillary thyroid carcinoma which mimics various benign and malignant lesions on thyroid aspiration cytology. As correct cytological diagnosis is the cornerstone for appropriate patient management, awareness of the salient cytomorphological characteristics of this tumor is essential. Here, we present cytological features of a case of WLPTC along with discussion of the common differential diagnoses and a brief review of the literature to ascertain the most consistent cytological findings of WLPTC...
April 27, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28449203/two-cases-of-adenocarcinoma-in-situ-arising-in-lobular-endocervical-glandular-hyperplasia-indicating-localization-of-mucin-on-the-cluster-surface-as-an-early-cytological-finding-of-malignant-transformation
#2
Rikiya Okuyama, Hirotsugu Hashimoto, Tamaki Miura, Masatoshi Sugita, Masakazu Arai, Hajime Tsunoda, Yuko Sasajima, Hajime Horiuchi
Lobular endocervical glandular hyperplasia (LEGH) is an endocervical glandular hyperplastic lesion containing pyloric gland-like mucin, and has recently been recognized as a precursor lesion of malignant glandular lesions of the endocervix. The pyloric gland-like mucin contained in LEGH and gastric-type adenocarcinoma is observed as golden-yellowish by Papanicolaou staining. However, to our knowledge, the chronological course of the endocervical cytology of LEGH, eventually resulting in malignancy, has never been demonstrated to date...
April 27, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28440063/micronuclei-and-nuclear-buds-highlighting-overlooked-indicators-of-chromosomal-damage-in-thyroid-aspiration-smears
#3
Tuba Dilay Kokenek-Unal, Ipek Coban
BACKGROUND: We aimed to examine the diagnostic utility of micronuclei (MN) and nuclear buds (NBs) in aspiration smears of the well-differentiated epithelial lesions of thyroid. METHODS: One hundred five cases composed of 34 follicular nodular disease (FND), 31 Hashimoto's thyroiditis (HT), and 40 papillary thyroid carcinoma (PTC) were compiled retrospectively. May- Grünwald Giemsa (MGG) stained smears of each case were selected to count cells with nuclear protrusions (NPs) per 1000 cells...
April 24, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28440023/cytomorphologic-features-of-echinococcal-cysts
#4
John David Paulsen, Paul Elgert, Melissa Yee-Chang, Xiao-Jun Wei, Yan Shi
No abstract text is available yet for this article.
April 24, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28436211/primary-hpv-testing-verification-a-retrospective-ad-hoc-analysis-of-screening-algorithms-on-women-doubly-tested-for-cytology-and-hpv
#5
Jessica Tracht, Allison Wrenn, Isam-Eldin Eltoum
BACKGROUND: To evaluate human papillomavirus (HPV) testing as a primary screening tool, we retrospectively analyzed data comparing (1) HPV testing to the algorithms of the ATHENA Study: (2) cytology alone, (3) cytology with ASCUS triage in women 25-29 and (4) cotesting ≥ 30 or (5) cotesting ≥ 25. METHODS: We retrospectively analyzed data from women tested with both cytology and HPV testing from 2010 to 2013. Cumulative risk (CR) for CIN3+ was calculated...
April 23, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28429425/accuracy-of-cytology-in-sub-typing-non-small-cell-lung-carcinomas
#6
Trupti S Patel, Majal G Shah, Jahnavi S Gandhi, Pratik Patel
BACKGROUND: Sub typing of non small cell lung carcinoma (NSCLC) has an important task in the era of molecular and targeted therapies. Differentiating between squamous cell carcinoma (SQCC) and adenocarcinoma (ADC) is challenging when limited material is available in lung carcinoma. We investigated the accuracy and feasibility of sub typing NSCLCs in cytology and small biopsy material. METHODS: Concurrent cytology and biopsy material obtained in a single CT- guided procedure in lung carcinoma over a year period retrospectively...
April 21, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28425211/importance-of-cytological-subclassification-of-thyroid-nodules-with-bethesda-category-iii-cytology-aus-flus-into-architectural-atypia-only-and-nuclear-atypia-a-prospective-study
#7
Pedro Weslley Rosario, Maria Regina Calsolari
BACKGROUND: The objective of this study was to compare two cytological subcategories of thyroid nodules with Bethesda category III initial cytology. METHODS: This was a prospective study. All patients with thyroid nodules > 1 cm were eligible and 98 patients with category III cytology were selected. Cytology was subcategorized into architectural atypia only (AA, n = 45) and nuclear atypia (NA, n = 53). All patients underwent a second fine-needle aspiration (FNA)...
April 19, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28421721/fnac-aided-diagnosis-of-clear-cell-sarcoma-of-kidney-report-of-two-cases-in-infants
#8
Indranil Das, Ram Narayan Das, Bibhas Saha Dalal, Janki Bisht, Banhishikha Kanjilal, Uttara Chatterjee
Clear cell sarcoma of kidney (CCSK) is a rare aggressive malignant renal neoplasm with a high metastatic potential. Its outcome has however, improved with the advent of doxorubicin based neoadjuvant chemotherapy. Here, we present two cases of CCSK in infants diagnosed on cytology followed by nephrectomy. The first case presented in the neonatal period and had the unusual histological finding of islands of cartilage. The second case presented at the age of eight months. The possibility of CCSK should, therefore, be considered in the differential diagnoses of renal masses in infants as well as neonates...
April 19, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28421714/endometrial-cells-on-pap-tests-ideal-reporting-is-more-complex-than-just-finding-the-right-age-ideal-reporting-of-endometrial-cells-on-pap-tests
#9
Gabor Fischer, Maha Haddad, Karen Cormier
BACKGROUND: The age for reporting normal endometrial cells (EMCs) on Pap tests was changed to ≥ 45 years in the latest Bethesda update (2014). This recommendation is solely based on age with no consensus on optimal reporting guidelines. METHODS: Pap tests with EMCs for women ≥40 years were retrieved from our Laboratory Information System (LIS). Patient age, last menstrual period (LMP) and available follow-up histology were recorded. Follow-up diagnoses were categorized as: no significant pathology, benign, hyperplasia ± atypia, or malignant...
April 19, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28421710/synovial-sarcoma-metastatic-to-the-parotid-gland-a-possible-pitfall-in-salivary-gland-fine-needle-aspiration-cytology-report-of-a-case-with-immunocytochemical-and-fluorescence-in-situ-hybridization-findings
#10
Franco Fulciniti, Jessica Barizzi, Vittoria Martin, Vittorio Tarallo, Stefano Ermanni
We report one case of metastatic synovial sarcoma (SS) to the parotid gland in a 93-year-old male. The patient had undergone upper left pulmonary lobectomy with mediastinal lymphadenectomy for SS of the lung 5 years before. The cytopathologic presentation and the immunocytochemical findings on the FNA sample were suggestive of a spindle cell myoepithelioma, while a SYT rearrangement was identified by a FISH performed on a cytological smear of the lesion. The diagnosis was further confirmed also by positive immunocytochemical expression of TLE1 on a section from the obtained cell block...
April 19, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28419774/double-trouble-concomitant-infection-of-esophagus-by-herpes-and-candida-in-diabetic-non-hiv-patients-report-of-two-cases
#11
Pavneet Kaur Selhi, Ruchita Tyagi, Vikram Narang, Vandana Midha, J S Sandhu
No abstract text is available yet for this article.
April 16, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28419773/non-invasive-follicular-neoplasm-with-papillary-like-nuclear-features-niftp-if-it-ain-t-broke-don-t-fix-it-the-cytopathologist-s-dilemma
#12
EDITORIAL
Virginia A LiVolsi, Lester Layfield, Zubair W Baloch
No abstract text is available yet for this article.
April 16, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28419762/hobnail-variant-of-papillary-thyroid-carcinoma-a-case-with-an-unusual-presentation
#13
Mohammed T Lilo, Justin A Bishop, Syed Z Ali
Variants of papillary thyroid carcinoma (PTC) account for up to 25% of the cases, some of which are proven to be associated with aggressive clinical behavior such as tall cell and columnar cell variants. Hobnail variant of PTC (HVPTC) is recently described as a rare and aggressive variant of PTC. Herein, we are reporting a case of HVPTC in a patient who presented with hemoptysis and an intratracheal blood clot that was aspirated and submitted for cytopathological examination. Cytomorphology displayed neoplastic cells with profound micropapillary architecture, elongated nuclei, and prominent hobnail configuration...
April 16, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28411397/chondrosarcoma-like-metastasis-from-a-poorly-differentiated-uterine-cervical-squamous-cell-carcinoma-a-unique-morphology-and-diagnostic-pitfall-in-cytology
#14
Shohei Ikoma, Marlo Nicolas, Jaishree Jagirdar, Maria Luisa Policarpio-Nicolas
Rare cases of metastatic squamous cell carcinoma with chondroid differentiation from esophageal primary have been reported but none from the uterine cervix. Given the rarity of this phenomenon and potential diagnostic pitfall, we present this unusual case. The patient is a 25-year-old woman who presented with shortness of breath. Computerized tomography (CT) showed several lung and pleural-based nodules. CT-guided core biopsy with touch preparations were performed on the pleural-based nodule. The touch preparations showed large, spindle-to-oval shaped cells with pleomorphic nuclei embedded in metachromatic chondroid stroma...
April 14, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28411396/the-usefulness-of-adding-p53-immunocytochemistry-to-bile-drainage-cytology-for-the-diagnosis-of-malignant-biliary-strictures
#15
Min-Kyung Yeo, Kyung-Hee Kim, Yong-Moon Lee, Byung Seok Lee, Song-Yi Choi
BACKGROUND: Obstructive jaundice is frequently caused by bile duct strictures. Determination of malignant strictures is crucial for the initiation of appropriate treatment. Cytologic examination of bile drainage fluid is an easy and reproducible method of detecting malignant cells. This method, however, frequently yields indeterminate results, such as atypia or suspicious of malignancy, due to difficulties in differentiating malignancy from benign atypia. Immunocytochemical assessment of p53 expression by cells in bile drainage fluid may enhance the ability to detect malignancy...
April 14, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28411379/ancillary-testing-strategies-in-salivary-gland-aspiration-cytology-a-practical-pattern-based-approach
#16
REVIEW
Christopher C Griffith, Momin T Siddiqui, Alessandra C Schmitt
Fine needle aspiration of salivary gland tumors is a common preoperative triage as it is useful in determining which patients should undergo surgical resection and in guiding the extent of surgery in those cases deemed appropriate for resection. While a specific diagnosis can be achieved on a cytologic specimen in many cases, there is also a considerable amount of morphologic diversity that prevents such confident preoperative classification and in these cases it can be a challenge to confidently determine if a tumor is benign or malignant...
April 14, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28398702/the-professional-twitter-account-creation-proper-maintenance-and-continuous-successful-operation
#17
REVIEW
Emilio Madrigal, Xiaoyin Sara Jiang, Sinchita Roy-Chowdhuri
Social networking platforms have created a unique venue for pathologists and associated stakeholders to communicate and share information in a rapidly proliferating field. Among the myriad of available platforms, Twitter has become one of the most widely accepted by healthcare professionals, for its ease of use, similarities to a real life conversation, and vast global reach. Although the adaptation rate of Twitter continues to grow, many healthcare professionals perceive the establishment and maintenance of an online presence to be a daunting task, leaving some on the outside, looking in...
April 11, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28398699/pneumocytoma-sclerosing-hemangioma-a-potential-pitfall
#18
Erika Hissong, Rema Rao
Pneumocytoma is an uncommon benign tumor of the lung, derived from primitive respiratory epithelium, with a predilection for middle-aged females. A single, well-circumscribed mass is commonly identified on imaging, necessitating pathologic evaluation for further assessment. Fine-needle aspiration cytology is a minimally invasive and cost-effective method that can be utilized in the diagnosis of these lesions. Yet, distinction of pneumocytoma from other entities such as well-differentiated adenocarcinoma or carcinoid tumor can be quite challenging...
April 11, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28397371/a-twitter-primer-dos-and-don-ts-for-cytopathologists
#19
EDITORIAL
Xiaoyin Sara Jiang, Emilio Madrigal, Sinchita Roy-Chowdhuri
No abstract text is available yet for this article.
April 11, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28397369/incidental-primary-mediastinal-choriocarcinoma-diagnosed-by-endobronchial-ultrasound-guided-fine-needle-aspiration-in-a-patient-presenting-with-transient-ischemic-attack-and-stroke
#20
Ivo M B Francischetti, Antonio Cajigas, Mark Suhrland, Joaquim M Farinhas, Samer Khader
We describe a case of a 41-year old male patient with no significant prior medical history who presents with symptoms of Transient Ischemic Attack and stroke. Magnetic Resonance Imaging (MRI) of the brain identified areas of ischemia in the left side, and angiography showed occlusion of the left Medial Cerebral Artery (MCA). Cardiac Transthoracic Echocardiogram (TTE) for stroke evaluation incidentally noted a mediastinal abnormality leading to cancer work-up. Computer Tomography (CT) and (18) F-fluorodeoxyglucose (FDG) PET-CT scan of the chest incidentally revealed an avid 6 cm paraesophagial/subcarinal mass...
April 11, 2017: Diagnostic Cytopathology
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