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Critical Reviews in Biotechnology

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https://www.readbyqxmd.com/read/28427287/downstream-protein-separation-by-surfactant-precipitation-a-review
#1
Fadzlie Wong Faizal Wong, Arbakariya B Ariff, David C Stuckey
In a conventional protein downstream processing (DSP) scheme, chromatography is the single most expensive step. Despite being highly effective, it often has a low process throughput due to its semibatch nature, sometimes with nonreproducible results and relatively complex process development. Hence, more work is required to develop alternative purification methods that are more cost-effective, but exhibiting nearly comparable performance. In recent years, surfactant precipitation has been heralded as a promising new method for primary protein recovery that meets these criteria and is a simple and cost-effective method that purifies and concentrates...
April 21, 2017: Critical Reviews in Biotechnology
https://www.readbyqxmd.com/read/28427274/first-principle-based-models-in-plant-suspension-cell-cultures-a-review
#2
Adriana Villegas, Juan Pablo Arias, Daira Aragón, Silvia Ochoa, Mario Arias
In this work, the development and application of published models for describing the behavior of plant cell cultures is reviewed. The structure of each type of model is analyzed and the new tendencies for the modeling of biotechnological processes that can be applied in plant cell cultures are presented. This review is a tool for clarifying the main features that characterize each type of model in the field of plant cell cultures and can be used as a support on the selection of the more suitable model type, taking into account the purpose of specific research...
April 21, 2017: Critical Reviews in Biotechnology
https://www.readbyqxmd.com/read/28427272/biological-technologies-for-the-remediation-of-co-contaminated-soil
#3
Shujing Ye, Guangming Zeng, Haipeng Wu, Chang Zhang, Juan Dai, Jie Liang, Jiangfang Yu, Xiaoya Ren, Huan Yi, Min Cheng, Chen Zhang
Compound contamination in soil, caused by unreasonable waste disposal, has attracted increasing attention on a global scale, particularly since multiple heavy metals and/or organic pollutants are entering natural ecosystem through human activities, causing an enormous threat. The remediation of co-contaminated soil is more complicated and difficult than that of single contamination, due to the disparate remediation pathways utilized for different types of pollutants. Several modern remediation technologies have been developed for the treatment of co-contaminated soil...
April 21, 2017: Critical Reviews in Biotechnology
https://www.readbyqxmd.com/read/28427282/biofouling-in-photobioreactors-for-marine-microalgae
#4
Ouassim Zeriouh, José Vicente Reinoso-Moreno, Lorenzo López-Rosales, María Del Carmen Cerón-García, Asterio Sánchez-Mirón, Francisco García-Camacho, Emilio Molina-Grima
The economic and/or energetic feasibility of processes based on using microalgae biomass requires an efficient cultivation system. In photobioreactors (PBRs), the adhesion of microalgae to the transparent PBR surfaces leads to biofouling and reduces the solar radiation penetrating the PBR. Light reduction within the PBR decreases biomass productivity and, therefore, the photosynthetic efficiency of the cultivation system. Additionally, PBR biofouling leads to a series of further undesirable events including changes in cell pigmentation, culture degradation, and contamination by invasive microorganisms; all of which can result in the cultivation process having to be stopped...
April 20, 2017: Critical Reviews in Biotechnology
https://www.readbyqxmd.com/read/28427280/progress-in-terpene-synthesis-strategies-through-engineering-of-saccharomyces-cerevisiae
#5
Kalaivani Paramasivan, Sarma Mutturi
Terpenes are natural products with a remarkable diversity in their chemical structures and they hold a significant market share commercially owing to their distinct applications. These potential molecules are usually derived from terrestrial plants, marine and microbial sources. In vitro production of terpenes using plant tissue culture and plant metabolic engineering, although receiving some success, the complexity in downstream processing because of the interference of phenolics and product commercialization due to regulations that are significant concerns...
April 20, 2017: Critical Reviews in Biotechnology
https://www.readbyqxmd.com/read/28425297/new-approaches-for-itaconic-acid-production-bottlenecks-and-possible-remedies
#6
Richa Bafana, R A Pandey
Currently, growing attention is being devoted to the conversion of biomass into value-added products, such as itaconic acid (IA), which is considered as the cleanest alternative to petroleum-based acrylic acid. IA is an unsaturated dicarboxylic acid that is used as a building block chemical for the production of several value-added products such as poly-itaconic acid. IA and its derivatives have a wide range of potential applications in textile, paint, pharmaceutical and chemical industries. Presently, industries are producing IA on the large scale by fermentation from glucose...
April 20, 2017: Critical Reviews in Biotechnology
https://www.readbyqxmd.com/read/28423958/strategies-and-perspectives-of-assembling-multi-enzyme-systems
#7
Shi-Zhen Wang, Yong-Hui Zhang, Hong Ren, Ya-Li Wang, Wei Jiang, Bai-Shan Fang
Multi-enzyme complexes have the potential to achieve high catalytic efficiency for sequence reactions due to their advantages in eliminating product inhibition, facilitating intermediate transfer and in situ regenerating cofactors. Constructing functional multi-enzyme systems to mimic natural multi-enzyme complexes is of great interest for multi-enzymatic biosynthesis and cell-free synthetic biotransformation, but with many challenges. Currently, various assembly strategies have been developed based on the interaction of biomacromolecules such as DNA, peptide and scaffolding protein...
April 20, 2017: Critical Reviews in Biotechnology
https://www.readbyqxmd.com/read/28423952/advances-in-the-research-of-celery-an-important-apiaceae-vegetable-crop
#8
Meng-Yao Li, Xi-Lin Hou, Feng Wang, Guo-Fei Tan, Zhi-Sheng Xu, Ai-Sheng Xiong
Celery (Apium graveolens L.), one of the most important vegetables in Apiaceae family, is cultivated worldwide and utilized in food and cosmetic industries because it is an excellent source of vitamins, phenolic compounds, volatile oils and other nutrients. Celery extracts possess various medicinal properties, such as antibacterial, anti-inflammatory and lowering blood glucose and serum lipid levels. With the rapid advancements in molecular biology and sequencing technology, studies on celery have been performed...
April 20, 2017: Critical Reviews in Biotechnology
https://www.readbyqxmd.com/read/28423948/fermentation-at-non-conventional-conditions-in-food-and-bio-sciences-by-the-application-of-advanced-processing-technologies
#9
Maria J Mota, Rita P Lopes, Mohamed Koubaa, Shahin Roohinejad, Francisco J Barba, Ivonne Delgadillo, Jorge A Saraiva
The interest in improving the yield and productivity values of relevant microbial fermentations is an increasingly important issue for the scientific community. Therefore, several strategies have been tested for the stimulation of microbial growth and manipulation of their metabolic behavior. One promising approach involves the performance of fermentative processes during non-conventional conditions, which includes high pressure (HP), electric fields (EF) and ultrasound (US). These advanced technologies are usually applied for microbial inactivation in the context of food processing...
April 20, 2017: Critical Reviews in Biotechnology
https://www.readbyqxmd.com/read/28423947/metabolic-engineering-strategies-for-acetoin-and-2-3-butanediol-production-advances-and-prospects
#10
Taowei Yang, Zhiming Rao, Xian Zhang, Meijuan Xu, Zhenghong Xu, Shang-Tian Yang
Acetoin and 2,3-butanediol (2,3-BD) have a large number of industrial applications. The production of acetoin and 2,3-BD has traditionally relied on oil supplies. Microbial production of acetoin and 2,3-BD will alleviate the dependence on oil. Acetoin and 2,3-BD are neighboring metabolites in the 2,3-BD metabolic pathway of bacteria. This review summarizes metabolic engineering strategies for improvement of microbial acetoin and 2,3-BD production. We also propose enhancements to current acetoin and 2,3-BD production strategies, by offering a metabolic engineering approach that is guided by systems biology and synthetic biology...
April 20, 2017: Critical Reviews in Biotechnology
https://www.readbyqxmd.com/read/28423946/tween-80-surfactant-enhanced-bioremediation-toward-a-solution-to-the-soil-contamination-by-hydrophobic-organic-compounds
#11
Min Cheng, Guangming Zeng, Danlian Huang, Chunping Yang, Cui Lai, Chen Zhang, Yang Liu
The occurrence of hydrophobic organic compounds (HOCs) in the soil has become a highly significant environmental issue. This problem has been exacerbated by the strong sorption of HOCs to the soils, which makes them unavailable for most remediation processes. More and more works show that surfactant-enhanced biological technologies offer a great potential to clear up HOCs-contaminated soils. This article is a critical review of HOCs removal from soils using Tween 80 (one of the mostly used nonionic surfactants) aided biological remediation technologies...
April 20, 2017: Critical Reviews in Biotechnology
https://www.readbyqxmd.com/read/28423945/on-line-soft-sensing-in-upstream-bioprocessing
#12
Judit Randek, Carl-Fredrik Mandenius
This review provides an overview and a critical discussion of novel possibilities of applying soft sensors for on-line monitoring and control of industrial bioprocesses. Focus is on bio-product formation in the upstream process but also the integration with other parts of the process is addressed. The term soft sensor is used for the combination of analytical hardware data (from sensors, analytical devices, instruments and actuators) with mathematical models that create new real-time information about the process...
April 20, 2017: Critical Reviews in Biotechnology
https://www.readbyqxmd.com/read/28423944/emerging-roles-of-long-non-coding-rnas-in-plant-response-to-biotic-and-abiotic-stresses
#13
Naghmeh Nejat, Nitin Mantri
Spectacular progress in high-throughput transcriptome sequencing and expression profiling using next-generation sequencing technologies have recently revolutionized molecular biology and allowed massive advances in identifying the genomic regions and molecular mechanisms underlying transcriptional regulation of growth, development, and stress response. Through recent research, non-coding RNAs, in particular long non-coding RNAs, have emerged as key regulators of transcription in eukaryotes. Long non-coding RNAs are vastly heterogeneous groups of RNAs that execute a broad range of essential roles in various biological processes at the epigenetic, transcriptional, and post-transcriptional levels...
April 20, 2017: Critical Reviews in Biotechnology
https://www.readbyqxmd.com/read/28423943/high-value-added-lipids-produced-by-microorganisms-a-potential-use-of-sugarcane-vinasse
#14
Bruna Soares Fernandes, João Paulo Fernandes Vieira, Fabiano Jares Contesini, Paulo Eduardo Mantelatto, Marcelo Zaiat, José Geraldo da Cruz Pradella
This review aims to present an innovative concept of high value added lipids produced by heterotrophic microorganisms, bacteria and fungi, using carbon sources, such as sugars, acids and alcohols that could come from sugarcane vinasse, which is the main byproduct from ethanol production that is released in the distillation step. Vinasse is a rich carbon source and low-cost feedstock produced in large amounts from ethanol production. In 2019, the Brazilian Ministry of Agriculture, Livestock and Food Supply estimates that growth of ethanol domestic consumption will be 58...
April 20, 2017: Critical Reviews in Biotechnology
https://www.readbyqxmd.com/read/28423942/natural-gums-of-plant-origin-as-edible-coatings-for-food-industry-applications
#15
Anuradha Saha, Shvetambri Tyagi, Rajinder K Gupta, Yogesh K Tyagi
Natural plant-based gums and their derivatives are widely utilized in food industries, however, their applications as edible coatings to extend fresh fruits and vegetable shelf-life has been explored recently. These natural polymeric polysaccharides have many advantages as compared to synthetic polymers, because they are biodegradable, nontoxic, economical and easily available in the environment. Natural gums can also be semi synthetically modified to produce derivatives, which can easily compete with the synthetic preservatives available on the food market...
April 20, 2017: Critical Reviews in Biotechnology
https://www.readbyqxmd.com/read/28399663/upstream-biomanufacturing-of-pharmaceutical-colchicine
#16
Ganapathy Sivakumar
The plant-based colchicine potentially affects major diseases such as cardiovascular events, cancers and gout. Gloriosa superba seeds are a conventional pharmaceutical source of colchicine. The demand for pharmaceutical-grade colchicine has increased due to the shortage of feasible upstream manufacturing, encompassing all stages in the processes of biosynthesis and biomanufacturing before the raw material is ready for purification. Consequently, developing sustainable upstream industrial colchicine biofactories is imperative, especially in curtailing drug costs...
April 12, 2017: Critical Reviews in Biotechnology
https://www.readbyqxmd.com/read/28395514/exiguobacterium-an-overview-of-a-versatile-genus-with-potential-in-industry-and-agriculture
#17
Ramesh C Kasana, C B Pandey
The bacterial genus Exiguobacterium accommodates many versatile species isolated from diverse environments. Exiguobacterium was described as a genus approximately three decades ago, and now, 17 species, growing over a broad range of temperatures and pH, have been recognized. Various isolates from different niches have been explored for biotechnological and industrial purposes, including enzyme production, bioremediation and degradation of toxic substances released into the environment. Some isolates possess plant growth promoting capabilities, and they are currently being explored for increasing agricultural production...
April 11, 2017: Critical Reviews in Biotechnology
https://www.readbyqxmd.com/read/28391705/microbial-cell-immobilization-in-biohydrogen-production-a-short-overview
#18
Patrick Thabang Sekoai, Ayotunde A Awosusi, Kelvin Odafe Yoro, Muofhe Singo, Olawale Oloye, Augustine Omoniyi Ayeni, Michael Bodunrin, Michael Olawale Daramola
The high dependence on fossil fuels has escalated the challenges of greenhouse gas emissions and energy security. Biohydrogen is projected as a future alternative energy as a result of its non-polluting characteristics, high energy content (122 kJ/g), and economic feasibility. However, its industrial production has been hampered by several constraints such as low process yields and the formation of biohydrogen-competing reactions. This necessitates the search for other novel strategies to overcome this problem...
April 10, 2017: Critical Reviews in Biotechnology
https://www.readbyqxmd.com/read/28330374/recent-developments-in-the-use-of-tyrosinase-and-laccase-in-environmental-applications
#19
Sidy Ba, Vaidyanathan Vinoth Kumar
Our current global environmental challenges include the reduction of harmful chemicals and their derivatives. Bioremediation has been a key strategy to control the massive presence of chemicals in the environment. Enzymes including the phenoloxidases, laccases and tyrosinases, are increasingly being investigated as "green products" in the removal of many chemical contaminants in waters and soils. Both phenoloxidases are widespread in nature and attractive biocatalysts due to their ability to use readily available molecular oxygen as sole cofactor for their catalytic elimination of a large number of chemicals...
March 22, 2017: Critical Reviews in Biotechnology
https://www.readbyqxmd.com/read/27737570/protein-secretion-in-corynebacterium-glutamicum
#20
Xiuxia Liu, Wei Zhang, Zihao Zhao, Xiaofeng Dai, Yankun Yang, Zhonghu Bai
Corynebacterium glutamicum, a Gram-positive bacterium, has been widely used for the industrial production of amino acids, such as glutamate and lysine, for decades. Due to several characteristics - its ability to secrete properly folded and functional target proteins into culture broth, its low levels of endogenous extracellular proteins and its lack of detectable extracellular hydrolytic enzyme activity - C. glutamicum is also a very favorable host cell for the secretory production of heterologous proteins, important enzymes, and pharmaceutical proteins...
June 2017: Critical Reviews in Biotechnology
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