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Immunological Investigations

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https://www.readbyqxmd.com/read/27982737/il-37-a-new-il-1-family-member-emerges-as-a-key-suppressor-of-asthma-mediated-by-mast-cells
#1
P Conti, G Ronconi, A Caraffa, G Lessiani, Kempuraj Duraisamy
: In 1986, we reported a multiple biological effect of IL-1 including immunological, inflammatory, and tumor killing activity. Since then other IL-1 family cytokines have been discovered, some with inflammatory and other with anti-inflammatory activity. In this review article, we speculate on the possible inhibitory effect of IL-37 in the light of new findings. IL-37, formerly termed IL-1 family member 7 (IL-1F7), binding IL-18 receptor α chain, acts as a cytokine with intracellular as well as extracellular functionality and as a natural inhibitor of immune responses and inflammation...
December 16, 2016: Immunological Investigations
https://www.readbyqxmd.com/read/27982730/meta-analysis-of-the-relationship-between-tnf-%C3%AE-308g-a-and-il-10-819c-t-gene-polymorphisms-and-susceptibility-to-dengue
#2
Ana Caroline Melo Dos Santos, Edilson Leite de Moura, Jean Moisés Ferreira, Barbara Rayssa Correia Dos Santos, Verônica de Medeiros Alves, Karol Fireman de Farias, Elaine Virgínia Martins de Souza Figueiredo
OBJECTIVE: This study determined whether tumor necrosis factor alpha (TNF-α) and Interleukin-10 (IL-10) polymorphisms are associated with susceptibility to dengue. METHODS: a systematic review with meta-analysis was conducted of the associations between the TNF-α (-308G/A) and IL-10 (-819C/T) polymorphisms and dengue. RESULTS: A total of eight case-controls studies involving 384 individuals with symptomatic dengue, 571 individuals with dengue hemorrhagic fever, and 995 healthy controls were considered in the meta-analysis...
December 16, 2016: Immunological Investigations
https://www.readbyqxmd.com/read/27967265/local-and-systemic-profiles-of-inflammatory-cytokines-in-carrageenan-induced-paw-inflammation-in-rats
#3
Parvathi Annamalai, Elden Berla Thangam
OBJECTIVE: Carrageenan (CA)-induced edema has been described as highly reproducible model of acute inflammation. However, little is known about the cytokines attributed to the CA-induced inflammation. In this study, we aimed to investigate the local and systemic expression profiles of various inflammatory cytokines following the subplantar injection of CA in rats. METHODOLOGY: Acute inflammation was induced in male Wistar rats by subplantar injection of CA. Serum and paw tissue were examined for the level of 19 specific inflammatory cytokines using antibody array...
December 14, 2016: Immunological Investigations
https://www.readbyqxmd.com/read/27967264/tamoxifen-attenuates-lipopolysaccharide-galactosamine-induced-acute-liver-failure-by-antagonizing-hepatic-inflammation-and-apoptosis
#4
Peng Zhang, Meisheng Zhang, Mengqi Wan, Xiaoliu Huang, Yan Jiang, Siying Xu, Mansheng Luo
Bacterial lipopolysaccharide (LPS)-induced acute liver failure (ALF) is a common severe clinical syndrome in intensive care unit. No other methods are available for its prevention apart from supportive treatment and liver transplantation. Tamoxifen (TAM) was reported to attenuate ALF induced by excessive acetaminophen, while its effect on LPS-induced ALF remained unknown. For this, in the present study, we comprehensively assessed whether TAM can attenuate ALF induced by LPS/galactosamine (GaIN). Mice were given TAM once a day for three times...
December 14, 2016: Immunological Investigations
https://www.readbyqxmd.com/read/27967259/vinpocetine-inhibited-the-cpg-oligodeoxynucleotide-induced-immune-response-in-plasmacytoid-dendritic-cells
#5
Xungang Feng, Yuzhong Wang, Yanlei Hao, Qun Ma, Jun Dai, Zhibo Liang, Yantao Liu, Xiangyuan Li, Yan Song, Chuanping Si
Plasmacytoid dendritic cells (pDCs) exert dual roles in immune responses through inducing inflammation and maintaining immune tolerance. A switch of pDC phenotype from pro-inflammation to tolerance has therapeutic promise in the treatment of autoimmune diseases. Vinpocetine, a vasoactive vinca alkaloid extracted from the periwinkle plant, has recently emerged as an immunomodulatory agent. In this study, we evaluated the effect of vinpocetine on phenotype of pDCs isolated from C57BL/6 mice and explored its possible mechanism...
December 14, 2016: Immunological Investigations
https://www.readbyqxmd.com/read/27960564/monocyte-chemoattractant-protein-1-mcp-1-ccl2-levels-and-its-association-with-renal-allograft-rejection
#6
Ali Raza, Sadaf Firasat, Shagufta Khaliq, Abdul Rafay Khan, Shafaq Mahmood, Tahir Aziz, Muhammad Mubarak, Syed Ali Anwar Naqvi, Syed Adibul Hasan Rizvi, Aiysha Abid
BACKGROUND: CCL2 is a chemoattractant for monocytes/macrophages, T cells, and natural killer cells. It is shown to be involved in the immunological responses against renal allograft. This study was conducted to access the role of urinary CCL2 expression in predicting the rejection episodes in renal transplant patients. METHOD: A total of 409 urine samples included in this study. The samples were consisted of (a) biopsy-proven graft rejection (n = 165); (b) non-rejection (n = 93); (c) non-biopsy stable-graft (n = 42), and (d) healthy renal donors (n = 109)...
December 14, 2016: Immunological Investigations
https://www.readbyqxmd.com/read/27911110/mannose-binding-lectin-deficiency-in-brazilian-patients-with-spondyloarthritis
#7
Thelma L Skare, Renato Nisihara, Juliana Z Cieslinski, João O Zeni, Henrique N Rasera, Iara Messias-Reason, Shirley R R Utiyama
BACKGROUND: Infections are usually involved in the pathogenesis of spondyloarthritis (SpA). Mannose-binding lectin (MBL) is a component of the innate immune system with an important role in microbial defense. OBJECTIVE: To study the prevalence of MBL deficiency in SpA patients as well as its influence in the clinical profile of these diseases. METHODS: We studied 89 SpA patients and 89 healthy individuals, paired for age and gender. MBL serum levels were measured by ELISA test...
December 2, 2016: Immunological Investigations
https://www.readbyqxmd.com/read/27911104/upregulation-of-t-cell-immunoglobulin-and-mucin-domain-containing-3-tim-3-in-monocytes-macrophages-associates-with-gastric-cancer-progression
#8
Zhenxin Wang, Ni Yin, Zixiang Zhang, Yi Zhang, Guangbo Zhang, Weichang Chen
T-cell immunoglobulin and mucin-domain containing-3 (Tim-3) is an important immune regulatory molecule in cancer immune system. However, expression and function of Tim-3 in monocytes/macrophages in cancer progression mainly remain unclear. In this study, we analyzed Tim-3 levels in peripheral blood mononuclear cells (PBMCs) from 62 gastric cancer patients and 45 healthy controls using flow cytometry and then associated Tim-3 levels with clinical pathological data from patients. We found Tim-3 level was significantly upregulated in monocytes from gastric cancer patients compared with those from healthy controls, and that upregulated Tim-3 levels associated with depth of tumor invasion and tumor lymph node metastasis and advanced clinical stages of gastric cancer patients...
December 2, 2016: Immunological Investigations
https://www.readbyqxmd.com/read/27911102/anti-cd14-antibody-treated-neutrophils-respond-to-lps-possible-involvement-of-cd14-upregulated-by-anti-cd14-antibody-binding
#9
Terukazu Sanui, Masaaki Takeshita, Takao Fukuda, Akira Haraguchi, Yoshitomi Aida, Fusanori Nishimura
CD14 and Toll-like receptor 4/MD2 (TLR4/MD2) mediate the action of LPS on neutrophils. The anti-CD14 antibody and the TLR4/MD2-antagonist, synthetic lipid IVa (LA-14-PP), are known to inhibit the response of neutrophils to LPS. We studied the role of CD14 in LPS-induced priming of neutrophils for enhanced release of the superoxide anion. The anti-CD14 antibody at much higher concentrations than required to saturate CD14 was required to inhibit priming by LPS. The inhibitory effect of the anti-CD14 antibody was overcome by LPS...
December 2, 2016: Immunological Investigations
https://www.readbyqxmd.com/read/27819528/interferon-gamma-ifn-%C3%AE-is-elevated-in-wound-exudate-from-hidradenitis-suppurativa
#10
Anirban Banerjee, Sean McNish, Victoria K Shanmugam
Hidradenitis suppurativa (HS) is a chronic recurrent inflammatory disease of apocrine glands which affects 1-4% of young adults. The purpose of this study was to investigate inflammatory cytokines in effluent from HS lesions and to identify potential local drivers of inflammation in HS. Wound fluid specimens from HS patients (n = 8) and age-matched chronic wound patients (n = 8) were selected for analysis. The hidradenitis suppurativa score (HSS) was used to determine the extent of HS activity. Cytokine analysis was conducted using Meso Scale Discovery cytokine and proinflammatory panels...
November 7, 2016: Immunological Investigations
https://www.readbyqxmd.com/read/27819527/tigit-a-novel-therapeutic-target-for-tumor-immunotherapy
#11
Xin-Guang Liu, Ming Hou, Yu Liu
Co-inhibitory and co-stimulatory receptors act in concert to regulate adaptive immune cell function, and the balance of these receptors is essential for the maintenance of immune homeostasis. Tumors constitute highly suppressive microenvironments in which elevated expression of co-inhibitory receptors on tumor-infiltrating lymphocytes (TILs) is often found. Functional blockade of the co-inhibitory receptors such as cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and programmed cell death 1 (PD-1) have yielded encouraging outcomes in tumors, generating substantial interest in seeking for additional co-inhibitory molecules that may act as potential interfering targets...
November 7, 2016: Immunological Investigations
https://www.readbyqxmd.com/read/27819525/il12-gene-polymorphism-in-association-with-hepatocellular-carcinoma-in-hcv-infected-egyptian-patients
#12
Heba Mosaad Elsayed, Yasmin Nabiel, Tarek Sheta
BACKGROUND: Hepatocellular carcinoma has been recorded the commonest cancer in Egypt. This increasing incidence may be attributed to the high prevalence of hepatitis C virus with its complications, so this study aimed to investigate the association between the potentially functional polymorphisms of IL12A and IL12B genes as a risk factor of development of hepatocellular carcinoma (HCC) on top of hepatitis C virus (HCV) infection in an Egyptian population. MATERIALS AND METHODS: We genotyped two loci of IL12 which were rs568408 (3'UTR G>A) for IL12A and rs3212227 (3'UTR A>C) for IL12B in 78 patients with HCC on top of chronic HCV infection...
November 7, 2016: Immunological Investigations
https://www.readbyqxmd.com/read/27819519/association-of-the-ifn-%C3%AE-874a-t-genetic-polymorphism-with-paranoid-schizophrenia-in-tunisian-population
#13
Achraf Jemli, Awatef Eshili, Fatma Trifa, Anouar Mechri, Ferid Zaafrane, Lotfi Gaha, George Juckel, Besma Bel Hadj Jrad Tensaout
Since growing evidence suggests a significant role of chronic low-grade inflammation in the physiopathology of schizophrenia, we have hypothesized that functional genetic variant of the IFN gamma (IFN-γ; +874A/T; rs2430561) gene may be involved in the predisposition to schizophrenia. This research is based on a case-control study which aims to identify whether polymorphism of the IFN-γ gene is a risk factor for the development of schizophrenia. The RFLP-PCR genotyping of the IFN-γ gene was conducted on a Tunisian population composed of 218 patients and 162 controls...
November 7, 2016: Immunological Investigations
https://www.readbyqxmd.com/read/27819517/polymorphisms-in-cd14-gene-may-modify-soluble-cd14-levels-and-represent-risk-factors-for-multiple-sclerosis
#14
Mehrdad Farrokhi, Pedram Moeini, Mohammad Fazilati, Habibollah Nazem, Shahla Faraji, Zahra Saadatpour, Elyas Fadaei, Leila Saadatpour, Ali Rezaei, Sadra Ansaripour, Ali Amani-Beni
BACKGROUND: Besides the central role of the adaptive immune system, a disturbance of innate immune system is also suggested to be involved in the pathogenesis of multiple sclerosis (MS). CD14, a receptor upregulated in activated microglia, is known to be an essential mediator of inflammation in innate immune responses. Therefore, in this study we aimed to assess possible roles of CD14-159 and -260 gene polymorphisms in MS susceptibility and the effects of those polymorphisms to its protein producing capacity in Iranian population...
November 7, 2016: Immunological Investigations
https://www.readbyqxmd.com/read/27798840/interferon-regulatory-factor-5-gene-polymorphisms-in-iranian-women-with-unexplained-recurrent-pregnancy-loss
#15
Rakhshan Amiri Jahromi, Mahboobeh Nasiri, Athar Rasekh Jahromi
OBJECTIVE: This study aimed to examine the association of three functional IRF5 rs10954213, rs3757385, and rs41298401 polymorphisms with susceptibility to unexplained recurrent pregnancy loss (RPL) among Iranian women from south of Iran. METHODS: 176 women with unexplained RPL and 173 healthy postmenopausal controls were enrolled in this case-control study. Genotyping of the polymorphisms rs10954213 and rs3757385 was carried out using touchdown tetra-primer amplification refractory mutation system-polymerase chain reaction (T-ARMS PCR), and polymorphism rs41298401 was typed using PCR-restriction fragment length polymorphism (PCR-RFLP)...
January 2017: Immunological Investigations
https://www.readbyqxmd.com/read/27759478/novel-mutation-of-zap-70-related-combined-immunodeficiency-first-case-from-the-national-iranian-registry-and-review-of-the-literature
#16
Afshin Shirkani, Mohammad Shahrooei, Gholamreza Azizi, Hassan Rokni-Zadeh, Hassan Abolhassani, Shokrollah Farrokhi, Glynis Frans, Xavier Bossuyt, Asghar Aghamohammadi
ZAP-70 deficiency is a rare autosomal recessive form of combined immunodeficiency (CID) characterized by selective absence of circulating CD8 T cells with low, normal, or increased CD4 T cells in peripheral blood. Up to now, 14 unique mutations in the ZAP70 gene have been identified in patients with ZAP-70-related CID. We present a 3-year-old boy with a history of recurrent bacterial infections and autoimmunity. Initial laboratory findings showed a normal total lymphocyte count, but low levels of CD8 and CD4 T cells and an abnormal lymphocyte proliferation response...
January 2017: Immunological Investigations
https://www.readbyqxmd.com/read/27736253/mesenchymal-stem-cells-upregulate-the-expression-of-pd-l1-but-not-vdr-in-dendritic-cells
#17
Ali Moravej, Mohammad-Hossein Karimi, Bita Geramizadeh, Negar Azarpira, Amir-Hasan Zarnani, Ramin Yaghobi, Maryam Khosravi, Mehdi Kalani, Behrouz Gharesi-Fard
OBJECTIVE: Mesenchymal stem cells (MSCs) show immunomodulatory functions. But the exact mechanism underlying these activities of MSCs is still not completely understood. There have been a few studies which have assessed the effects of these cells on dendritic cells (DCs) function. Given the importance of programmed cell death receptor-1 (PD-L1) and vitamin D receptor (VDR) expression in induction of tolerance in DCs, we were encouraged to investigate if one of the immunomodulatory functions of MSCs could be inducing upregulation of PD-L1 and VDR on DCs or not...
January 2017: Immunological Investigations
https://www.readbyqxmd.com/read/27648678/clinical-association-of-a-soluble-triggering-receptor-expressed-on-myeloid-cells-1-strem-1-in-patients-with-systemic-lupus-erythematosus
#18
Iman H Bassyouni, Samar Fawzi, Tamer A Gheita, Rasha H Bassyouni, Aml S Nasr, Samah A El Bakry, Naglaa Afifi
A triggering receptor expressed on myeloid cells-1 (TREM-1) is a member of the immunoglobulin superfamily with an established role in innate and adaptive immune response. We aimed to determine the plasma concentrations and clinical association of sTREM-1 in Systemic Lupus Erythematosus (SLE) patients. Plasma from 79 SLE patients and 35 normal healthy subjects were assayed for sTREM-1 and IL-6 levels using Enzyme Linked Immunosorbant Assay (ELISA). The clinical disease characteristics and serological data were prospectively assessed...
January 2017: Immunological Investigations
https://www.readbyqxmd.com/read/27618158/differences-in-cytokine-production-during-aging-and-its-relationship-with-antimicrobial-peptides-production
#19
Julio E Castañeda-Delgado, Isabel Frausto-Lujan, Irma González-Curiel, Alejandra Montoya-Rosales, Carmen J Serrano, Flor Torres-Juarez, Jose A Enciso-Moreno, Bruno Rivas-Santiago
Aging is a major health issue due to the increased susceptibility of elderly people to infectious, autoimmune, and cardiovascular diseases. Innate immunity is an important mechanism to avoid primary infections; therefore, decreasing of its activity may lead to development of infections. Antimicrobial peptides (AMPs) are effector molecules of innate immunity that can eliminate microbial invaders. The role that cytokines play in the regulation of these innate immune mechanisms needs to be explored. Serum determinations of Th1, Th2, and Th17 cytokines were performed in order to evaluate their association with AMPs human beta-defensin (HBD)-2 and LL-37 in young adults, elder adults, and elder adults with recurrent infections...
January 2017: Immunological Investigations
https://www.readbyqxmd.com/read/27617892/cytokine-effects-on-mechano-induced-electrical-activity-in-atrial-myocardium
#20
V Kazanski, V M Mitrokhin, M I Mladenov, A G Kamkin
: The role of cytokines as regulators of stretch-related mechanisms is of special importance since mechano-sensitivity plays an important role in a wide variety of biological processes. Here, we elucidate the influence of cytokine application on mechano-sensitivity and mechano-transduction. The atrial myocardial stretch induces production of interleukin (IL)-2, IL-6, IL-13, IL-17A, and IL-18 with exception of tumor necrosis factor α (TNF-α), IL-1β, and vascular endothelial growth factor B (VEGF-B)...
January 2017: Immunological Investigations
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