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Immunological Investigations

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https://www.readbyqxmd.com/read/28799818/the-expression-and-clinical-signification-of-pd-1-in-lymph-nodes-of-patients-with-non-small-cell-lung-cancer
#1
Haitao Ma, GuoCai Mao, GuangBo Zhang, HaiTao Huang
To screen anti-programmed cell death protein 1 (PD-1) antibody treatment of the dominant population, it is necessary to understand the expression of PD-1 in tumor metastasis microenvironment. The aim of the present study was to detect the expression of PD-1 in lymph nodes of 51 patients with non-small cell lung cancer (NSCLC) by using flow cytometry (FCM). The results showed that the PD-1 expression on CD3(+) T cells was significantly increased in NSCLC metastatic lymph nodes (50.08 ± 8.03%) compared with nonmetastatic lymph nodes (36...
August 11, 2017: Immunological Investigations
https://www.readbyqxmd.com/read/28753407/il-29-enhances-cxcl10-production-in-tnf-%C3%AE-stimulated-human-oral-epithelial-cells
#2
Yoshitaka Hosokawa, Ikuko Hosokawa, Satoru Shindo, Kazumi Ozaki, Takashi Matsuo
Interleukin-29 (IL-29) is a cytokine belonging to the Type III interferon family. It was recently detected in the gingival crevicular fluid of periodontitis patients. However, the role of IL-29 in the pathogenesis of periodontal disease remains unknown. The aim of this study was to examine the effects of IL-29 on C-X-C motif chemokine ligand 10 (CXCL10) production in human oral epithelial cells. We measured CXCL10 production in TR146 cells, which is a human oral epithelial cell line, using an enzyme-linked immunosorbent assay...
August 2017: Immunological Investigations
https://www.readbyqxmd.com/read/28753406/association-of-established-thyroid-stimulating-hormone-and-free-thyroxine-genetic-variants-with-hashimoto-s-thyroiditis
#3
Luka Brčić, Sanda Gračan, Ana Barić, Ivana Gunjača, Vesela Torlak Lovrić, Ivana Kolčić, Tatijana Zemunik, Ozren Polašek, Maja Barbalić, Ante Punda, Vesna Boraska Perica
Hashimoto's thyroiditis (HT), the most frequent autoimmune thyroid disease (AITD), is characterized by chronic inflammation of the thyroid gland that usually results in hypothyroidism. Thyroid-stimulating hormone (TSH) and free thyroxine (FT4) levels are used as clinical determinants of thyroid function. The main aim of this study was to explore the association of established TSH and FT4 genetic variants with HT. We performed a case-control analysis using 23 genetic markers in 200 HT patients and 304 controls...
August 2017: Immunological Investigations
https://www.readbyqxmd.com/read/28742417/mica-129met-val-polymorphism-is-associated-with-early-onset-breast-cancer-risk
#4
Nesrine Ouni, Arij Ben Chaaben, Ghalia Kablouti, Mohamed Lajnef, Fayza Ayari, Hajer Abaza, Tarek Damak, Latifa Harzallah, Amel Benammar-Elgaaeid, Fethi Guemira, Ryad Tamouza
The major histocompatibility complex class I-related chain A (MICA), expressed on cell surface, plays an important role in the elimination of both virus-infected cells and tumor through the activation of the natural killer (NK) receptor NKG2D. A polymorphic change from methionine (Met) to valine (Val) at amino acid position 129 categorizes MICA alleles into strong and weak binders for the NKG2D receptor and has been found in a variety of immune-related disorders. In this study, we investigated the potential interaction between genetic polymorphism of MICA and the development of breast cancer...
August 2017: Immunological Investigations
https://www.readbyqxmd.com/read/28742415/air-and-dust-borne-fungi-in-indoor-and-outdoor-home-of-allergic-patients-in-a-dust-storm-affected-area
#5
Elham Shabankarehfard, Afshin Ostovar, Shokrollah Farrokhi, Behrouz Naeimi, Sasan Zaeri, Shahrokh Nazmara, Mozhgan Keshtkar, Farzaneh Sadeghzadeh, Sina Dobaradaran
Despite the recent increases in fungi-induced allergic diseases, there is no report yet in the region of the Persian Gulf on concentration levels of fungi in relationship with health state. Therefore, our aim was to measure fungi prevalence as well as to evaluate the relationships between air- and dust-borne fungal genera and allergic diseases. A matched case-control study was carried out including 45 allergic cases and 45 age- and gender-matched controls for each individual. Indoor and outdoor dust and indoor air samples were collected from participant homes during May to October 2015...
August 2017: Immunological Investigations
https://www.readbyqxmd.com/read/28742407/tlr5-polymorphisms-rs2072493-rs5744174-and-rs5744168-are-not-genetic-risk-factors-for-chronic-helicobacter-pylori-infection-in-indian-tamils
#6
Vaishnavi Goda, Megala Jayaraman, Rekha Loganathan, Mehnaz Nazeer, Mohammed Ali, Premkumar Karunakaran, Panneer Devaraju
The incidence of Helicobacter pylori (H. pylori) infection and gastric cancer is on the rise in India, and the genetic factors influencing the increased susceptibility in Indian population remain obscure. Toll-like receptors (TLRs) play a major role in innate immune system and genetic polymorphisms affecting their function were reported to enhance the risk for H. pylori infection. Seventy-seven patients (n = 77) diagnosed with H. pylori infection and 230 healthy subjects were recruited in this study. The rs2072493, rs5744174, and rs5744168 polymorphisms within TLR5 gene were genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and Tetra-ARMS PCR genotyping techniques...
August 2017: Immunological Investigations
https://www.readbyqxmd.com/read/28742404/pregnane-x-receptor-polymorphisms-and-risk-of-inflammatory-bowel-disease-a-meta-analysis
#7
Xiaolan Guo, Ming Yan
BACKGROUND: Pregnane X receptor (PXR) gene polymorphisms have been widely studied in terms of the association with inflammatory bowel disease (IBD), with inconsistent results. OBJECTIVE: The present meta-analysis was performed to assess the association between PXR gene polymorphisms and the susceptibility of IBD, Crohn's disease (CD), and ulcerative colitis (UC). METHODS: PubMed, Wanfang, and CNKI databases were searched for eligible studies before November 1, 2016...
August 2017: Immunological Investigations
https://www.readbyqxmd.com/read/28742402/association-of-il-10-regulating-micrornas-in-peripheral-blood-mononuclear-cells-with-the-pathogenesis-of-autoimmune-thyroid-disease
#8
Yukina Takuse, Mikio Watanabe, Naoya Inoue, Ritsuko Ozaki, Hiroshi Ohtsu, Minori Saeki, Yuka Katsumata, Yoh Hidaka, Yoshinori Iwatani
Interleukin (IL)-10 is known to suppress inflammation in autoimmune diseases. IL-10 can be regulated by miRNAs. To elucidate the involvement of miRNAs that regulate IL-10 expression with the pathogenesis of autoimmune thyroid disease (AITD), we examined the expression levels of hsa-miR-27a-3p, hsa-miR-98-5p, hsa-miR-106a-5p, and hsa-miR-223-3p in peripheral blood mononuclear cells (PBMCs) from 43 patients with Graves' disease (GD), 38 patients with Hashimoto's disease (HD), and 21 healthy volunteers. We evaluated the association between the expression levels of four miRNAs and intracellular expression of IL-10 in PBMCs from 11 healthy volunteers...
August 2017: Immunological Investigations
https://www.readbyqxmd.com/read/28742401/chikungunya-virus-seroprevalence-and-associated-factors-among-hospital-attendees-in-two-states-of-southwest-nigeria-a-preliminary-assessment
#9
Olayinka M Olajiga, Olajumoke E Adesoye, Adewale P Emilolorun, Abiodun J Adeyemi, Emmanuel O Adeyefa, Ismail A Aderibigbe, Salmot A Adejumo, Wasiu O Adebimpe, Oluyinka O Opaleye, Waidi F Sule, Daniel O Oluwayelu
Chikungunya virus (CHIKV) is a re-emerging pathogen causing long-term polyarthritis and encephalitis. In conducting a preliminary investigation, we hypothesized that there is no serologic evidence of CHIKV infection among attendees of selected hospitals in Lagos and Osun States, Nigeria. Sera from 304 consecutively selected participants were screened for CHIKV IgG and IgM using ELISA. Findings were analyzed vis-à-vis participants' demographic and clinical data. Over 90.0% of the participants had never heard of CHIKV despite the fact that a large proportion of them (88...
August 2017: Immunological Investigations
https://www.readbyqxmd.com/read/28742400/role-of-different-cd40-polymorphisms-in-graves-disease-and-hashimoto-s-thyroiditis
#10
Dongguo Wang, Jiayu Chen, Huanyuan Zhang, Fangfang Zhang, Linjun Yang, Yonghua Mou
Genome-wide association studies have led to the discovery of several susceptibility genes related to autoimmune thyroid diseases (AITDs). However, controversial results have been reported regarding the role of single-nucleotide polymorphism (SNP) of CD40 in the disease susceptibility. The objective of this study was to identify the relationship of the polymorphisms of three sites of CD40 with the susceptibility to AITD in the Chinese population. We genotyped three polymorphisms of CD40: C/T -1 SNP, 58038T site of the third exon and C64610G site of the ninth exon in 196 GD cases, 121 HT cases and 122 control subjects...
August 2017: Immunological Investigations
https://www.readbyqxmd.com/read/28535114/association-of-pd-1-5-c-t-but-not-pd-1-3-g-a-with-malignant-and-benign-brain-tumors-in-iranian-patients
#11
Fatemeh Namavar Jahromi, Morteza Samadi, Zahra Mojtahedi, Mohammad Reza Haghshenas, Mosa Taghipour, Nasrollah Erfani
Programmed death-1 (PD-1) negatively regulates the immune response. The aims of this study were to assess the association of two single nucleotide polymorphisms in the PD-1 gene, PD-1.5 (+7785 C/T-rs2227981) and PD-1.3 (+7146 G/A- rs11568821), with benign and malignant brain tumors. Patients with brain tumors (96 patients with benign and 56 with malignant brain tumors) and 150 healthy control individuals were included. PCR-RFLP was performed for genotyping. It was revealed that the genotype and allele frequencies of PD-1...
July 2017: Immunological Investigations
https://www.readbyqxmd.com/read/28414590/reduction-in-cd16-cd56-and-cd16-cd3-cd56-natural-killer-cells-in-coronary-artery-disease
#12
Nasimudeen R Jabir, Chelapram K Firoz, Farid Ahmed, Mohammad A Kamal, Salwa Hindawi, Ghazi A Damanhouri, Hussein A Almehdar, Shams Tabrez
BACKGROUND: Natural killer (NK) cells are the potential modulators of inflammatory reactions that exert several unique biological effects and could lead to future adverse events of coronary artery disease (CAD). HYPOTHESIS: The purpose of this study was to find out the possible association of modulation in NK cell, TNK cells, T cells, B cells, and tumor necrosis factor alpha (TNF-α) in CAD patients and various forms of myocardial infarction. METHODS: The present study included total 190 subjects (98 confirmed CAD patients both men and women and 92 healthy control individuals)...
July 2017: Immunological Investigations
https://www.readbyqxmd.com/read/28414589/progesterone-decreases-in-vitro-indoleamine-2-3-dioxygenase-expression-in-dendritic-and-cd4-cells-from-maternal-fetal-interface-of-rats
#13
Pedro Kastein Faria da Cunha Bianchi, Rafael Magdanelo Leandro, Aline Nayara Poscai, Tulio Yoshinaga, Patrícia Orlandini Gonçalez, José Roberto Kfoury Junior
PROBLEM: Several mechanisms contribute to the tolerogenic state observed during pregnancy, such as the activity of the enzyme indoleamine 2, 3-dioxygenase (IDO). This initializes the catabolism of tryptophan, inducing T cells to apoptosis due to its deprivation and by the action of its catabolites in the placental microenvironment. Progesterone plays an important part on immunological tolerance mechanisms during pregnancy; however, there is no evidence it is related to IDO activity. Thus, this study aimed to investigate progesterone influence on the maternal-fetal interface of pregnant Wistar rats, by identifying IDO positive cells by immunophenotyping and flow cytometry under exogenous progesterone supplementation...
July 2017: Immunological Investigations
https://www.readbyqxmd.com/read/28414558/th17-inducing-conditions-lead-to-in-vitro-activation-of-both-th17-and-th1-responses-in-behcet-s-disease
#14
Rabia Deniz, Aysın Tulunay-Virlan, Filiz Ture Ozdemir, Ali Ugur Unal, Gulsen Ozen, Fatma Alibaz-Oner, Imren Aydin-Tatli, Gonca Mumcu, Tulin Ergun, Haner Direskeneli
OBJECTIVES: Interleukin-17 (IL-17) has been associated with the pathogenesis of various autoimmune/inflammatory diseases. The aim of this study was to investigate the expression of Th17-related immunity in an innate immunity-dominated vasculitis, namely Behcet's disease (BD). METHODS: Peripheral blood mononuclear cells from 37 patients (age: 38.5 ± 9.8 years) with BD, and 25 healthy controls (HC) (age: 39.1 ± 9.3 years), were cultured in Th17-inducing conditions (IL-6, Phytohemagglutinin (PHA), IL-1β, and IL-23) for 6 days...
July 2017: Immunological Investigations
https://www.readbyqxmd.com/read/28388279/investigation-of-aid-dicer-and-drosha-expressions-in-patients-with-chronic-lymphocytic-leukemia
#15
Metin Yusuf Gelmez, Ender Coskunpinar, Basak Saracoglu, Gunnur Deniz, Melih Aktan
Chronic lymphocytic leukemia (CLL) is the most common leukemia in Western countries. Cytogenetic lesions such as del13q14, del11q22.3, and del17p13 are identified in 50-60% of patients. Activation-induced cytidine deaminase (AID) plays a central role in somatic hyper mutation (SHM) and class switch recombination (CSR) and functions on Ig genes, but also target non-Ig genes, and over-expression of AID can lead to point mutations or translocations in non-Ig genes such as IgH/Myc translocation. Dicer and Drosha, which have a role in activation process of miRNA, also act in a double-strand DNA break (DSB) repair mechanism...
July 2017: Immunological Investigations
https://www.readbyqxmd.com/read/28388268/matrix-metalloproteinase-9-rs17576-gene-polymorphism-and-beh%C3%A3-et-s-disease-is-there-an-association
#16
Asmaa Kamal, Fatema T Elgengehy, Mohamed Momtaz Abd Elaziz, Sherif M Gamal, Nesreen Sobhy, Amira Medhat, Al Hussein M El Dakrony
BACKGROUND: Clinical studies have reported a significant association between matrix metalloproteinases (MMP), particularly (MMP-9), and inflammatory diseases including Behçet's disease (BD). PURPOSE: To study the relationship between MMP-9 rs17576 gene polymorphism and the development of BD, and its relation to disease activity among Egyptian patients. METHODS: A total of 100 BD patients and 100 healthy control volunteers were genotyped for MMP-9 rs17576 polymorphism with polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), followed by the confirmation of our results in random subgroups using direct DNA sequencing technique...
July 2017: Immunological Investigations
https://www.readbyqxmd.com/read/28388234/variable-heavy-chain-domain-derived-from-a-cell-penetrating-anti-dna-monoclonal-antibody-for-the-intracellular-delivery-of-biomolecules
#17
Sun-Woo Im, Pavithra Pravinsagar, Sae-Ran Im, Young-Ju Jang
Targeting and modification of important intracellular proteins using efficient vehicles are invaluable in diagnostic and therapeutic fields. Cell-penetrating antibodies and their fragments can be utilized as vehicles for the delivery of modifiers into cells. In this study, we explored the applicability of variable heavy chain (VH) domain as delivery vehicles for mammalian cells. The characteristics of the recombinant VH domain produced from a cell-penetrating monoclonal anti-double stranded DNA antibody 2C10 were analyzed using flow cytometry, confocal microscopy, cell proliferation assay, and cell cycle analysis in various mammalian cell lines...
July 2017: Immunological Investigations
https://www.readbyqxmd.com/read/28375749/immunization-with-recombinantly-expressed-lrp4-induces-experimental-autoimmune-myasthenia-gravis-in-c57bl-6-mice
#18
Canan Ulusoy, Filiz Çavuş, Vuslat Yılmaz, Erdem Tüzün
BACKGROUND: Myasthenia gravis (MG) is an autoimmune disease of the neuromuscular junction (NMJ), characterized with muscle weakness. While MG develops due to acetylcholine receptor (AChR) antibodies in most patients, antibodies to muscle-specific receptor tyrosine kinase (MuSK) or low-density lipoprotein receptor-related protein 4 (LRP4) may also be identified. Experimental autoimmune myasthenia gravis (EAMG) has been previously induced by both LRP4 immunization and passive transfer of LRP4 antibodies...
July 2017: Immunological Investigations
https://www.readbyqxmd.com/read/28358227/the-effect-of-surgical-stress-on-postoperative-t%C3%AE-%C3%AE-and-t%C3%AE-%C3%AE-cell-distribution
#19
Andrzej Gryglewski, Marian Szczepanik
BACKGROUND: It was previously shown that appropriate distribution of immune cells between different tissues and organs of the body is required for proper function of the immune system. Our previous experiments demonstrated that surgical trauma in mice induces Tγδ lymphocyte migration from peripheral blood to peritoneal lymphoid organs. Tγδ cells have regulatory activity as they suppress the cell-mediated immune response in vitro via TGF-β. In the current study, we aim to evaluate the influence of surgery on both Taβ and Tγδ lymphocyte distribution in patients that underwent operation...
July 2017: Immunological Investigations
https://www.readbyqxmd.com/read/28375710/high-interleukin-10-expression-in-type-2-t-helper-cells-in-septic-patients
#20
Huang-Pin Wu, Chien-Ming Chu, Kuo-Chin Kao, Shu-Huan Huang, Duen-Yau Chuang
Interleukin (IL)-10 response is associated with mortality in patients with sepsis. IL-10 is primarily produced by monocytes and type 2 T helper (Th2) cells. The aim of this study was to investigate differences in IL-10 production between monocytes and Th2 cells in patients with sepsis. Forty patients with sepsis and 35 healthy controls were enrolled. Cytokine expressions in peripheral blood mononuclear cells (PBMCs) were measured by flow cytometry. The IL-10 expression in the Th2 cells of the septic patients was higher than in the healthy controls, but the expression of IL-10 in the monocytes of the septic patients was lower than in the healthy controls...
May 2017: Immunological Investigations
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