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Journal of Pineal Research

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https://www.readbyqxmd.com/read/29292521/melatonin-redirects-carbohydrates-metabolism-during-sugar-starvation-in-plant-cells
#1
Agnieszka Kobylińska, Sławomir Borek, Małgorzata M Posmyk
Recent studies have shown that melatonin is an important molecule in plant physiology. It seems that the most important is that melatonin efficacy eliminates oxidative stress (direct and indirect antioxidant) and moreover induce plant stress reaction and switch on different defence strategies (preventively and interventively actions). In this report the impact of exogenous melatonin on carbohydrate metabolism in Nicotiana tabacum L. line Bright Yellow 2 (BY-2) suspension cells during sugar starvation was examined...
January 2, 2018: Journal of Pineal Research
https://www.readbyqxmd.com/read/29285799/biological-effects-of-melatonin-on-osteoblast-osteoclast-co-cultures-bone-and-quality-of-life-implications-of-a-role-for-mt2-melatonin-receptors-mek1-2-and-mek5-in-melatonin-mediated-osteoblastogenesis
#2
Sifat Maria, Rebekah M Samsonraj, Fahima Munmun, Jessica Glas, Maria Silvestros, Mary P Kotlarczyk, Ryan Rylands, Amel Dudakovic, Andre J van Wijnen, Larry T Enderby, Holly Lassila, Bala Dodda, Vicki L Davis, Judy Balk, Matt Burow, Bruce A Bunnell, Paula A Witt-Enderby
The Melatonin Osteoporosis Prevention Study (MOPS) demonstrated that nightly melatonin resulted in a time-dependent decrease in equilibrium ratios of serum osteoclasts and osteoblasts in perimenopausal women. This study examines mechanisms related to the ratios of osteoblasts and osteoclasts using co-culture models (transwell or layered) of human mesenchymal stem cell (MSCs) and human peripheral blood monocytes (PBMCs). Human MSCs/PBMCs co-cultures exposed to melatonin in osteogenic (OS+) medium for 21 days induced osteoblast differentiation and mineralization; however, only in layered co-cultures did melatonin inhibit osteoclastogenesis...
December 28, 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/29274168/prophylactic-supplement-with-melatonin-successfully-suppresses-the-pathogenesis-of-periodontitis-through-normalizing-rankl-opg-ratio-and-depressing-the-tlr4-myd88-signaling-pathway
#3
Ting-Yi Renn, Yung-Kai Huang, Sheng-Wei Feng, Hsiao-Wei Wang, Wei-Fang Lee, Che-Tong Lin, Thierry Burnouf, Li-You Chen, Pan-Fu Kao, Hung-Ming Chang
Periodontitis (PD) is an inflammatory disease characterized by gingival inflammation and resorption of alveolar bone. Impaired receptor activator of nuclear factor-kappa B ligand/osteoprotegerin (RANKL/OPG) signaling caused by enhanced production of pro-inflammatory cytokines plays an essential role in the pathogenesis of PD. Considering melatonin possesses significant anti-inflammatory property, present study aims to determine whether prophylactic treatment with melatonin would effectively normalize RANKL/OPG signaling, depress toll-like receptor 4/myeloid differentiation factor 88 (TLR4/MyD88) mediated pro-inflammatory cytokine activation, and successfully suppress the pathogenesis of PD...
December 23, 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/29247559/rice-histone-deacetylase-10-and-arabidopsis-histone-deacetylase-14-genes-encode-n-acetylserotonin-deacetylase-which-catalyzes-conversion-of-n-acetylserotonin-into-serotonin-a-reverse-reaction-for-melatonin-biosynthesis-in-plants
#4
Kyungjin Lee, Hyoung Yool Lee, Kyoungwhan Back
In plants, melatonin production is strictly regulated, unlike the production of its precursor, serotonin, which is highly inducible in response to stimuli, such as senescence and pathogen exposure. Exogenous serotonin treatment does not greatly induce the production of N-acetylserotonin (NAS) and melatonin in plants, which suggests the possible existence of one or more regulatory genes in the pathway for the biosynthesis of melatonin from serotonin. In this report, we found that NAS was rapidly and abundantly converted into serotonin in rice seedlings, indicating the presence of an N-acetylserotonin deacetylase (ASDAC)...
December 16, 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/29247557/combination-of-melatonin-and-rapamycin-for-head-and-neck-cancer-therapy-suppression-of-akt-mtor-pathway-activation-and-activation-of-mitophagy-and-apoptosis-via-mitochondrial-function-regulation
#5
Ying-Qiang Shen, Ana Guerra-Librero, Beatriz I Fernandez-Gil, Javier Florido, Sergio García-López, Laura Martinez-Ruiz, Miguel Mendivil-Perez, Viviana Soto-Mercado, Darío Acuña-Castroviejo, Hector Ortega-Arellano, Victor Carriel, María E Diaz-Casado, Russel J Reiter, Iryna Rusanova, Ana Nieto, Luis C López, Germaine Escames
Head and neck squamous cell carcinoma (HNSCC) clearly involves activation of the Akt mammalian target of rapamycin (mTOR) signalling pathway. However, the effectiveness of treatment with the mTOR inhibitor rapamycin is often limited by chemoresistance. Melatonin suppresses neoplastic growth via different mechanisms in a variety of tumours. In the present study, we aimed to elucidate the effects of melatonin on rapamycin-induced HNSCC cell death, and to identify potential cross-talk pathways. We analysed the dose-dependent effects of melatonin in rapamycin-treated HNSCC cell lines (Cal-27 and SCC-9)...
December 16, 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/29247550/melatonin-prevents-hypochlorous-acid-mediated-cyanocobalamin-destruction-and-cyanogen-chloride-generation
#6
Roohi Jeelani, Dhiman Maitra, Charalampos Chatzicharalampous, Syed Najeemuddin, Robert T Morris, Husam M Abu-Soud
Hypochlorous acid (HOCl) is a potent cytotoxic oxidant generated by the enzyme myeloperoxidase (MPO) in the presence of hydrogen peroxide (H2 O2 ) and chloride (Cl- ). Elevated levels of HOCl play an important role in various pathological conditions through oxidative modification of several biomolecules. Recently, we have highlighted the ability of HOCl to mediate the destruction of the metal-ion derivatives of tetrapyrrole macrocyclic rings such as hemoproteins and vitamin B12 (VB12 ) derivatives. Destruction of cyanocobalamin, a common pharmacological form of VB12 mediated by HOCl, results in the generation of toxic molecular products such as chlorinated derivatives, corrin ring cleavage products, the toxic blood agents cyanide (CN- ) and cyanogen chloride (CNCl), and redox active free cobalt...
December 16, 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/29247541/nocturnal-activation-of-melatonin-receptor-type-1-signaling-modulates-diurnal-insulin-sensitivity-via-regulation-of-pi3k-activity
#7
Sharon Owino, Aida Sánchez-Bretaño, Cynthia Tchio, Erika Cecon, Angeliki Karamitri, Julie Dam, Ralf Jockers, Giuseppe Piccione, Hye Lim Noh, Taekyoon Kim, Jason K Kim, Kenkichi Baba, Gianluca Tosini
Recent genetic studies have highlighted the potential involvement of melatonin receptor 1 (MT1 ) and melatonin receptor 2 (MT2 ) in the pathogenesis of type 2 diabetes. Here we report that mice lacking MT1 (MT1 KO) tend to accumulate more fat mass than WT mice and exhibit marked systemic insulin resistance. Additional experiments revealed that the main insulin signaling pathway affected by the loss of MT1 was the activation of phosphatidylinositol-3-kinase (PI3K). Transcripts of both catalytic and regulatory subunits of PI3K were strongly down-regulated within MT1 KO mice...
December 16, 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/29149522/melatonin-improves-the-meiotic-maturation-of-porcine-oocytes-by-reducing-endoplasmic-reticulum-stress-during-in-vitro-maturation
#8
Hyo-Jin Park, Jae-Young Park, Jin-Woo Kim, Seul-Gi Yang, Jae-Min Jung, Min-Ji Kim, Man-Jong Kang, Young Ho Cho, Gabbine Wee, Hee-Young Yang, Bong-Seok Song, Sun-Uk Kim, Deog-Bon Koo
Under endoplasmic reticulum (ER)-stress conditions, the unfolded protein response (UPR) generates a defense mechanism in mammalian cells. The regulation of UPR signaling is important in oocyte maturation, embryo development, and female reproduction of pigs. Recent studies have shown that melatonin plays an important role as an anti-oxidant to improve pig oocyte maturation. However, there is no report on the role of melatonin in the regulation of UPR signaling and ER-stress during in vitro maturation (IVM) of porcine oocytes...
November 17, 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/29149494/inhibiting-mt2-tfe3-dependent-autophagy-enhances-melatonin-induced-apoptosis-in-tongue-squamous-cell-carcinoma
#9
Tengfei Fan, Huifeng Pi, Min Li, Zhenhu Ren, Zhijing He, Feiya Zhu, Li Tian, Manyu Tu, Jia Xie, Mengyu Liu, Yuming Li, Miduo Tan, Gaoming Li, Weijia Qing, Russel J Reiter, Zhengping Yu, Hanjiang Wu, Zhou Zhou
Autophagy modulation is a potential therapeutic strategy for tongue squamous cell carcinoma (TSCC). Melatonin possesses significant anti-carcinogenic activity. However, whether melatonin induces autophagy and its roles in cell death in TSCC are unclear. Herein, we show that melatonin induced significant apoptosis in the TSCC cell line Cal27. Apart from the induction of apoptosis, we demonstrated that melatonin-induced autophagic flux in Cal27 cells as evidenced by the formation of GFP-LC3 puncta, and the upregulation of LC3-II and downregulation of SQSTM1/P62...
November 17, 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/29149482/melatonin-alleviates-low-ps-i-limited-carbon-assimilation-under-elevated-co2-and-enhances-the-cold-tolerance-of-offspring-in-chlorophyll-b-deficient-mutant-wheat
#10
Xiangnan Li, Marian Brestic, Dun-Xian Tan, Marek Zivcak, Xiancan Zhu, Shengqun Liu, Fengbin Song, Russel J Reiter, Fulai Liu
Melatonin is involved in the regulation of carbohydrate metabolism and induction of cold tolerance in plants. The objective of this study was to investigate the roles of melatonin in modulation of carbon assimilation of wild type wheat and the Chl b-deficient mutant ANK32B in response to elevated CO2 concentration ([CO2 ]) and the transgenerational effects of application of exogenous melatonin (hereafter identified as melatonin priming) on the cold tolerance in offspring. The results showed that the melatonin priming enhanced the carbon assimilation in ANK32B under elevated [CO2 ], via boosting the activities of ATPase and sucrose synthesis and maintaining a relatively higher level of total chlorophyll concentration in leaves...
November 17, 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/29149481/neuroprotective-effects-of-melatonin-on-amphetamine-induced-dopaminergic-fiber-degeneration-in-the-hippocampus-of-postnatal-rats
#11
Tanawan Leeboonngam, Ratchadaporn Pramong, Kwankanit Sae-Ung, Piyarat Govitrapong, Pansiri Phansuwan-Pujito
Chronic amphetamine (AMPH) abuse leads to damage of the hippocampus, the brain area associated with learning and memory process. Previous results have shown that AMPH-induced dopamine neurotransmitter release, reactive oxygen species formation, and degenerative protein aggregation lead to neuronal death. Melatonin, a powerful antioxidant, plays a role as a neuroprotective agent. The objective of this study was to investigate whether the protective effect of melatonin on AMPH-induced hippocampal damage in the postnatal rat acts through the dopaminergic pathway...
November 17, 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/29149454/melatonin-alleviates-adipose-inflammation-through-elevating-%C3%AE-ketoglutarate-and-diverting-adipose-derived-exosomes-to-macrophages-in-mice
#12
Zhenjiang Liu, Lu Gan, Tiantian Zhang, Qian Ren, Chao Sun
Obesity is associated with macrophage infiltration and metabolic inflammation, both of which promote metabolic disease progression. Melatonin is reported to possess anti-inflammatory properties by inhibiting inflammatory response of adipocytes and macrophages activation. However, the effects of melatonin on the communication between adipocytes and macrophages during adipose inflammation remain elusive. Here, we demonstrated melatonin alleviated inflammation and elevated α-ketoglutarate (αKG) level in adipose tissue of obese mice...
November 17, 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/29149453/melatonin-and-serotonin-mediators-in-the-symphony-of-plant-morphogenesis
#13
Lauren A E Erland, Mukund R Shukla, Amritpal S Singh, Susan J Murch, Praveen K Saxena
Melatonin and serotonin are important signaling and stress mitigating molecules that play important roles across growth and development in plants. Despite many well-documented responses, a systematic investigation of the entire metabolic pathway (tryptophan, tryptamine and N-acetylserotonin) does not exist, leaving many open questions. The objective of this study was to determine the responses of Hypericum perforatum (L.) to melatonin, serotonin and their metabolic precursors. Two well characterized germplasm lines (#4 and 112) created by mutation and a haploid breeding program were compared to wildtype to identify specific responses...
November 17, 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/29151275/rav-transcription-factors-are-essential-for-disease-resistance-against-cassava-bacterial-blight-via-activation-of-melatonin-biosynthesis-genes
#14
Yunxie Wei, Yanli Chang, Hongqiu Zeng, Guoyin Liu, Chaozu He, Haitao Shi
With 1 AP2 domain and 1 B3 domain, 7 MeRAVs in apetala2/ethylene response factor (AP2/ERF) gene family have been identified in cassava. However, the in vivo roles of these remain unknown. Gene expression assays showed that the transcripts of MeRAVs were commonly regulated after Xanthomonas axonopodis pv manihotis (Xam) and MeRAVs were specifically located in plant cell nuclei. Through virus-induced gene silencing (VIGS) in cassava, we found that MeRAV1 and MeRAV2 are essential for plant disease resistance against cassava bacterial blight, as shown by the bacterial propagation of Xam in plant leaves...
January 2018: Journal of Pineal Research
https://www.readbyqxmd.com/read/28833461/melatonin-limits-paclitaxel-induced-mitochondrial-dysfunction-in-vitro-and-protects-against-paclitaxel-induced-neuropathic-pain-in-the-rat
#15
Helen F Galley, Barry McCormick, Kirsten L Wilson, Damon A Lowes, Lesley Colvin, Carole Torsney
Chemotherapy-induced neuropathic pain is a debilitating and common side effect of cancer treatment. Mitochondrial dysfunction associated with oxidative stress in peripheral nerves has been implicated in the underlying mechanism. We investigated the potential of melatonin, a potent antioxidant that preferentially acts within mitochondria, to reduce mitochondrial damage and neuropathic pain resulting from the chemotherapeutic drug paclitaxel. In vitro, paclitaxel caused a 50% reduction in mitochondrial membrane potential and metabolic rate, independent of concentration (20-100 μmol/L)...
November 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/28776759/melatonin-ameliorates-hypoglycemic-stress-induced-brain-endothelial-tight-junction-injury-by-inhibiting-protein-nitration-of-tp53-induced-glycolysis-and-apoptosis-regulator
#16
Cheng-Kun Wang, Muhammad Masood Ahmed, Quan Jiang, Nan-Nan Lu, Chao Tan, Yin-Ping Gao, Qaisar Mahmood, Dan-Yang Chen, Kohji Fukunaga, Mei Li, Zhong Chen, Christopher S Wilcox, Ying-Mei Lu, Zheng-Hong Qin, Feng Han
Severe hypoglycemia has a detrimental impact on the cerebrovasculature, but the molecular events that lead to the disruption of the integrity of the tight junctions remain unclear. Here, we report that the microvessel integrity was dramatically compromised (59.41% of wild-type mice) in TP53-induced glycolysis and apoptosis regulator (TIGAR) transgenic mice stressed by hypoglycemia. Melatonin, a potent antioxidant, protects against hypoglycemic stress-induced brain endothelial tight junction injury in the dosage of 400 nmol/L in vitro...
November 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/28749565/melatonin-suppresses-platelet-activation-and-function-against-cardiac-ischemia-reperfusion-injury-via-ppar%C3%AE-fundc1-mitophagy-pathways
#17
Hao Zhou, Dandan Li, Pingjun Zhu, Shunying Hu, Nan Hu, Sai Ma, Ying Zhang, Tianwen Han, Jun Ren, Feng Cao, Yundai Chen
Platelet activation is a major (patho-) physiological mechanism that underlies ischemia/reperfusion (I/R) injury. In this study, we explored the molecular signals for platelet hyperactivity and investigated the beneficial effects of melatonin on platelet reactivity in response to I/R injury. After reperfusion, peroxisome proliferator-activated receptor γ (PPARγ) was progressively downregulated in patients with acute myocardial infarction undergoing coronary artery bypass grafting (CABG) surgery and in mice with I/R injury model...
November 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/29024030/melatonin-prevents-endothelial-cell-pyroptosis-via-regulation-of-long-noncoding-rna-meg3-mir-223-nlrp3-axis
#18
Yong Zhang, Xin Liu, Xue Bai, Yuan Lin, Zhange Li, Jiangbo Fu, Mingqi Li, Tong Zhao, Huan Yang, Ranchen Xu, Jiamin Li, Jin Ju, Benzhi Cai, Chaoqian Xu, Baofeng Yang
Atherosclerosis (AS) is an inflammatory disease linked to endothelial dysfunction. Melatonin is reported to possess substantial anti-inflammatory properties, which has proven to be effective in AS. Emerging literature suggests that pyroptosis plays a critical role during AS progression. However, whether pyroptosis contributes to endothelial dysfunction and the underlying molecular mechanisms remained unexploited. This study was designed to investigate the anti-pyroptotic effects of melatonin in atherosclerotic endothelium and to elucidate the potential mechanisms...
October 11, 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/29024001/dynamin-related-protein-1-mediated-mitochondrial-fission-contributes-to-post-traumatic-cardiac-dysfunction-in-rats-and-the-protective-effect-of-melatonin
#19
Mingge Ding, Jiao Ning, Na Feng, Zeyang Li, Zhenhua Liu, Yuanbo Wang, Yueming Wang, Xing Li, Cong Huo, Xin Jia, Rong Xu, Feng Fu, Xiaoming Wang, Jianming Pei
Mechanical trauma (MT) causes myocardial injury and cardiac dysfunction. However, the underlying mechanism remains largely unclear. This study investigated the role of mitochondrial dynamics in post-traumatic cardiac dysfunction and the protective effects of melatonin. Adult male Sprague Dawley rats were subjected to 5-minute rotations (200 revolutions at a rate of 40 rpm) to induce MT model. Melatonin was administrated intraperitoneally 5 minute after MT. Mitochondrial morphology, myocardial injury, and cardiac function were determined in vivo...
October 11, 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/28981157/effects-of-melatonin-on-fatty-liver-disease-the-role-of-nr4a1-dna-pkcs-p53-pathway-mitochondrial-fission-and-mitophagy
#20
Hao Zhou, Wenjuan Du, Ye Li, Chen Shi, Nan Hu, Sai Ma, Weihu Wang, Jun Ren
Mitochondrial dysfunction has been implicated in the pathogenesis of nonalcoholic fatty liver disease (NAFLD) through poorly defined mechanisms. Melatonin supplementation has been found to protect liver function in diabetes and obesity. Here, we intensively explored the role and mechanism of melatonin in the development of NAFLD. We demonstrated that the onset of diet-induced NAFLD greatly caused NR4A1 upregulation in hepatocytes, leading to the activation of DNA-PKcs and p53. On the one hand, p53 aided Drp1 migration in the mitochondria and consequently drove mitochondrial fission...
October 5, 2017: Journal of Pineal Research
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