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Journal of Pineal Research

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https://www.readbyqxmd.com/read/28796402/protection-of-melatonin-in-experimental-models-of-newborn-hypoxic-ischemic-brain-injury-through-mt1-receptor
#1
Bharati Sinha, Qiaofeng Wu, Wei Li, Yanyang Tu, Ana C Sirianni, Yanchun Chen, Jiying Jiang, Xinmu Zhang, Shuanhu Zhou, Wu Chen, Russel J Reiter, Simon Manning, Nirav J Patel, Ali M Aziz-Sultan, Terri E Inder, Robert M Friedlander, Jianfang Fu, Xin Wang
The function of melatonin as a protective agent against newborn hypoxic-ischemic (H-I) brain injury is not yet well studied, and the mechanisms by which melatonin causes neuroprotection in neurological diseases is still evolving. The present study was designed to investigate whether expression of MT1 receptors is reduced in newborn H-I brain injury and whether the protective action of melatonin is by alterations of the MT1 receptors. We demonstrated that there was significant reduction in MT1 receptors in ischemic brain of mouse pups in vivo following H-I brain injury and that melatonin offers neuroprotection through upregulation of MT1 receptors...
August 10, 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/28793366/cadmium-induced-melatonin-synthesis-in-rice-requires-light-hydrogen-peroxide-and-nitric-oxide-key-regulatory-roles-for-tryptophan-decarboxylase-and-caffeic-acid-o-methyltransferase
#2
Kyungjin Lee, Geun-Hee Choi, Kyoungwhan Back
In plants, melatonin production is induced by stimuli such as cold and drought, and cadmium (Cd) is the best elicitor of melatonin production in rice. However, the mechanism by which Cd induces melatonin synthesis in plants remains unknown. We challenged rice seedlings with Cd under different light conditions and found that continuous light produced the highest levels of melatonin, while continuous dark failed to induce melatonin production. Transcriptional and translational induction of tryptophan decarboxylase contributed to the light induction of melatonin during Cd treatment, whereas the protein level of light-induced caffeic acid O-methyltransferase (COMT) was decreased by Cd treatment...
August 9, 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/28793364/melatonin-reduces-inflammatory-response-in-peripheral-t-helper-lymphocytes-from-relapsing-remitting-multiple-sclerosis-patients
#3
Nuria Álvarez-Sánchez, Ivan Cruz-Chamorro, María Díaz-Sánchez, Helia Sarmiento-Soto, Pablo Medrano-Campillo, Alicia Martínez-López, Patricia Judith Lardone, Juan Miguel Guerrero, Antonio Carrillo-Vico
Multiple sclerosis (MS) is a neuroinflammatory disease of the central nervous system in which the immune system plays a central role. In particular, effector populations such as T helper (Th) 1, Th9, Th17 and Th22 cells are involved in disease development, whereas T regulatory cells (Tregs) are associated with the resolution of the disease. Melatonin levels are impaired in MS patients, and exogenous melatonin ameliorates the disease in MS animal models by modulating the Th1/Th17/Treg responses and also improves quality of life and several symptoms in MS patients...
August 9, 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/28776759/melatonin-ameliorates-hypoglycemic-stress-induced-brain-endothelial-tight-junction-injury-by-inhibiting-protein-nitration-of-tp53-induced-glycolysis-and-apoptosis-regulator-tigar
#4
Cheng-Kun Wang, Muhammad Masood Ahmed, Quan Jiang, Nan-Nan Lu, Chao Tan, Yin-Ping Gao, Qaisar Mahmood, Dan-Yang Chen, Kohji Fukunaga, Mei Li, Zhong Chen, Christopher S Wilcox, Ying-Mei Lu, Zheng-Hong Qin, Feng Han
Severe hypoglycemia has a detrimental impact on the cerebrovasculature, but the molecular events that lead to the disruption of the integrity of the tight junctions remains unclear. Here, we report that the microvessel integrity was dramatically compromised (59.41% of wild type mice) in TP53-induced glycolysis and apoptosis regulator (TIGAR) transgenic mice stressed by hypoglycemia. Melatonin, a potent antioxidant, protects against hypoglycemic stress-induced brain endothelial tight junction injury in the dosage of 400 nM in vitro...
August 4, 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/28776755/maternal-administration-of-melatonin-exerts-short-and-long-term-neuroprotective-effects-on-the-offspring-from-lipopolysaccharide-treated-mice
#5
Ana Paula Domínguez Rubio, Fernando Correa, Julieta Aisemberg, Damián Dorfman, María Victoria Bariani, Ruth Rosenstein, María Zorrilla Zubilete, Ana María Franchi
Preterm birth is a major contributor to early and delayed physical and cognitive impairment. Epidemiological and experimental data indicate that maternal infections are a significant and preventable cause of preterm birth. Recently, melatonin has been suggested to exert neuroprotective effects in several models of brain injury. Here we sought to investigate whether the administration of melatonin is able to prevent LPS-induced fetal brain damage in a model of lipopolysaccharide (LPS)-induced preterm labor. For this purpose, 15-days pregnant BALB/c mice received intraperitoneally two doses of lipopolysaccharide (LPS) or vehicle, the first one at 10:00 h (0...
August 4, 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/28749565/melatonin-suppresses-platelet-activation-and-function-against-cardiac-ischemia-reperfusion-injury-via-ppar%C3%AE-fundc1-mitophagy-pathways
#6
Hao Zhou, Dandan Li, Pingjun Zhu, Shunying Hu, Nan Hu, Sai Ma, Ying Zhang, Tianwen Han, Jun Ren, Feng Cao, Yundai Chen
Platelet activation is a major (patho-) physiological mechanism that underlies ischemia/reperfusion (I/R) injury. In this study, we explored the molecular signals for platelet hyperactivity and investigated the beneficial effects of melatonin on platelet reactivity in response to I/R injury. After reperfusion, peroxisome proliferator-activated receptor γ (PPARγ) was progressively downregulated in patients with acute myocardial infarction undergoing coronary artery bypass grafting (CABG) surgery and in mice with I/R injury model...
July 27, 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/28719035/melatonin-inhibits-nucleus-pulposus-np-cell-proliferation-and-extracellular-matrix-ecm-remodeling-via-the-melatonin-membrane-receptors-mediated-pi3k-akt-pathway
#7
Zheng Li, Xingye Li, Chong Chen, Matthew T V Chan, William Ka Kei Wu, Jianxiong Shen
Pinealectomy in vertebrates accelerated intervertebral disc degeneration (IDD). However, the potential mechanisms, particularly, melatonin's role is still to be clarified. In this study, for first time, melatonin membrane receptors of MT1 and MT2 were found to be present in the human intervertebral disc tissues and nucleus pulposus (NP) cells, respectively. Melatonin treatment significantly inhibited NP cell proliferation in dose- dependent manner. Accordingly, melatonin down-regulated gene expression of cyclin D1, PCNA, matrix metallopeptidases-3 and -9 and upregulated gene expression of collagen type II alpha 1 chain and aggrecan in NP cells...
July 18, 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/28718992/melatonin-impedes-tet1-dependent-mglur5-promoter-demethylation-to-relieve-pain
#8
Ming-Chun Hsieh, Yu-Cheng Ho, Cheng-Yuan Lai, Dylan Chou, Hsueh-Hsiao Wang, Gin-Den Chen, Tzer-Bin Lin, Hsien-Yu Peng
Melatonin (N-acetyl-5-methoxytryptamine)/MT2 receptor-dependent epigenetic modification represents a novel pathway in the treatment of neuropathic pain. Because spinal ten-eleven translocation methylcytosine dioxygenase 1 (Tet1)-dependent epigenetic demethylation has recently been linked to pain hypersensitivity, we hypothesized that melatonin/MT2-dependent analgesia involves spinal Tet1-dependent demethylation. Here, we showed that spinal Tet1 gene transfer by intrathecal delivery of Tet1-encoding vectors to naïve rats produced profound and long-lasting nociceptive hypersensitivity...
July 18, 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/28708271/melatonin-protects-against-the-pathological-cardiac-hypertrophy-induced-by-transverse-aortic-constriction-through-activating-pgc-1%C3%AE-in-vivo-and-in-vitro-studies
#9
Mengen Zhai, Zhenhua Liu, Bin Zhang, Lin Jing, Buying Li, Kaifeng Li, Xiuju Chen, Meng Zhang, Bo Yu, Kai Ren, Yang Yang, Wei Yi, Jian Yang, Jincheng Liu, Dinghua Yi, Hongliang Liang, Zhenxiao Jin, Russel J Reiter, Weixun Duan, Shiqiang Yu
Melatonin, a circadian molecule secreted by the pineal gland, confers a protective role against cardiac hypertrophy induced by hyperthyroidism, chronic hypoxia and isoproterenol. However, its role against pressure overload-induced cardiac hypertrophy and the underlying mechanisms remain elusive. In this study, we investigated the pharmacological effects of melatonin on pathological cardiac hypertrophy induced by transverse aortic constriction (TAC). Male C57BL/6 mice underwent TAC or sham surgery at day 0 and were then treated with melatonin (20 mg/kg/day, via drinking water) for 4 or 8 weeks...
July 14, 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/28708259/rapid-modulation-of-the-silent-information-regulator-1-sirt1-by-melatonin-after-hypoxia-ischemia-in-the-neonatal-rat-brain
#10
Silvia Carloni, Giulia Riparini, Giuseppe Buonocore, Walter Balduini
Increasing evidence indicates that melatonin possesses protective effects toward different kinds of damage in various organs, including the brain. In a neonatal model of hypoxia-ischemia (HI), melatonin was neuroprotective and preserved the expression of the Silent Information Regulator 1 (SIRT1) 24h after the insult. This study aimed to gain more insight into the role of SIRT1 in the protective effect of melatonin after HI by studying the early (1h) modulation of SIRT1 and its downstream targets, and the consequences on necrosis, apoptosis, autophagy and glial cell activation...
July 14, 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/28658527/melatonin-protects-against-maternal-obesity-associated-oxidative%C3%A2-stress-and-meiotic-defects-in-oocytes-via-the-sirt3-sod2-dependent-pathway
#11
Longsen Han, Haichao Wang, Ling Li, Xiaoyan Li, Juan Ge, Russel J Reiter, Qiang Wang
Maternal obesity in humans is associated with poor outcomes across the reproductive spectrum. Emerging evidence indicates that these defects are likely attributed to factors within the oocyte. Although various molecules and pathways may contribute to impaired oocyte quality, prevention of fertility issues associated with maternal obesity is a challenge. Using mice fed a high-fat diet (HFD) as an obesity model, we document spindle disorganization, chromosome misalignment, and elevated reactive oxygen species (ROS) levels in oocytes from obese mice...
June 28, 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/28658519/synergistic-effect-of-melatonin-and-ghrelin-in-preventing-cisplatin-induced-ovarian-damage-via-regulation-of-foxo3a-phosphorylation-and-binding-to-the-p27-kip1-promoter-in-primordial-follicles
#12
Hoon Jang, Younghwa Na, Kwonho Hong, Sangho Lee, Sohyeon Moon, Minha Cho, Miseon Park, Ok-Hee Lee, Eun Mi Chang, Dong Ryul Lee, Jung Jae Ko, Woo Sik Lee, Youngsok Choi
Premature ovarian failure during chemotherapy is a serious problem for young women with cancer. To preserve the fertility of these patients, approaches to prevent chemotherapy-induced ovarian failure are needed. In a previous study, we reported that melatonin treatment prevents the depletion of the dormant follicle pool via repression of the simultaneous activation of dormant primordial follicles by cisplatin. However, melatonin's protective effect was only partial and thus insufficient. In this study, we found that the hormone ghrelin enhances the protective effect of melatonin against cisplatin-induced ovarian failure in mouse model...
June 28, 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/28658514/the-role-and-therapeutic-potential-of-melatonin-in-age-related-ocular-diseases
#13
REVIEW
Almudena Crooke, Fernando Huete-Toral, Basilio Colligris, Jesús Pintor
The eye is continuously exposed to solar UV radiation and pollutants, making it prone to oxidative attacks. In fact, oxidative damage is a major cause of age-related ocular diseases including cataract, glaucoma, age-related macular degeneration, and diabetic retinopathy. As the nature of lens cells, trabecular meshwork cells, retinal ganglion cells, retinal pigment epithelial cells, and photoreceptors is postmitotic, autophagy plays a critical role in their cellular homeostasis. In age-related ocular diseases, this process is impaired, and thus, oxidative damage becomes irreversible...
June 28, 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/28599069/plant-mitochondria-synthesize-melatonin-and-enhance-the-tolerance-of-plants-to-drought-stress
#14
Lin Wang, Chao Feng, Xiaodong Zheng, Yan Guo, Fangfang Zhou, Dongqian Shan, Xuan Liu, Jin Kong
Synthesis of melatonin in mitochondria was reported in animals. However, there is no report on whether plant mitochondria also produce melatonin. Herein, we show that plant mitochondria are a major site for melatonin synthesis. In an in vitro study, isolated apple mitochondria had the capacity to generate melatonin. Subcellular localization analysis documented that an apple SNAT isoform, MzSNAT5, was localized in the mitochondria of both Arabidopsis protoplasts and apple callus cells. The kinetic analysis revealed that the recombinant MzSNAT5 protein exhibited high enzymatic activity to catalyze serotonin to N-acetylserotonin with the Km and Vmax of 55 μM and 0...
June 9, 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/28580724/melatonin-delays-photoreceptor-degeneration-in-a-mouse-model-of-autosomal-recessive-retinitis-pigmentosa
#15
Xiao-Jian Xu, Shu-Min Wang, Ying Jin, Yun-Tao Hu, Kang Feng, Zhi-Zhong Ma
Retinitis pigmentosa (RP) comprises a group of incurable inherited retinal degenerations. Targeting common processes, instead of mutation specific treatment, has proven to be an innovative strategy to combat debilitating retinal degeneration. Growing evidence indicates that melatonin possesses a potent activity against neurodegenerative disorders by mitigating cell damage associated with apoptosis and inflammation. Given the pleiotropic role of melatonin in central nervous system, the aim of the present study was to investigate whether melatonin would afford protection against retinal degeneration in autosomal recessive RP (arRP)...
June 5, 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/28580641/melatonin-reduces-endoplasmic-reticulum-stress-and-corneal-dystrophy-associated-tgfbip-through-activation-of-endoplasmic-reticulum-associated-protein-degradation
#16
Seung-Il Choi, Eunhee Lee, Begum Akuzum, Jang Bin Jeong, Yong-Sun Maeng, Tae-Im Kim, Eung Kweon Kim
Endoplasmic reticulum (ER) stress is emerging as a factor for the pathogenesis of granular corneal dystrophy type 2 (GCD2). This study was designed to investigate the molecular mechanisms underlying the protective effects of melatonin on ER stress in GCD2. Our results showed that GCD2 corneal fibroblasts were more susceptible to ER stress-induced death than were wild-type cells. Melatonin significantly inhibited GCD2 corneal cell death, caspase-3 activation, and poly (ADP-ribose) polymerase 1 cleavage caused by the ER stress inducer, tunicamycin...
June 5, 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/28580603/enhancement-of-high-glucose-induced-pink1-expression-by-melatonin-stimulates-neuronal-cell-survival-involvement-of-mt2-akt-nf-%C3%AE%C2%BAb-pathway
#17
Xaykham Onphachanh, Hyun Jik Lee, Jae Ryong Lim, Young Hyun Jung, Jun Sung Kim, Chang Woo Chae, Sei-Jung Lee, Amr Ahmed Gabr, Ho Jae Han
Hyperglycemia is a representative hallmark and risk factor for diabetes mellitus (DM) and is closely linked to DM-associated neuronal cell death. Previous investigators reported on a genome-wide association study and showed relationships between DM and melatonin receptor (MT), highlighting the role of MT signaling by assessing melatonin in DM. However, the role of MT signaling in DM pathogenesis is unclear. Therefore, we investigated the role of mitophagy regulators in high glucose-induced neuronal cell death and the effect of melatonin against high glucose-induced mitophagy regulators in neuronal cells...
June 5, 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/28398674/melatonin-protects-cardiac-microvasculature-against-ischemia-reperfusion-injury-via-suppression-of-mitochondrial-fission-vdac1-hk2-mptp-mitophagy-axis
#18
Hao Zhou, Ying Zhang, Shunying Hu, Chen Shi, Pingjun Zhu, Qiang Ma, Qinhua Jin, Feng Cao, Feng Tian, Yundai Chen
The cardiac microvascular system, which is primarily composed of monolayer endothelial cells, is the site of blood supply and nutrient exchange to cardiomyocytes. However, microvascular ischemia/reperfusion injury (IRI) following percutaneous coronary intervention is a woefully neglected topic, and few strategies are available to reverse such pathologies. Here, we studied the effects of melatonin on microcirculation IRI and elucidated the underlying mechanism. Melatonin markedly reduced infarcted area, improved cardiac function, restored blood flow, and lower microcirculation perfusion defects...
August 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/28295567/melatonin-reverses-h2-o2-induced-senescence-in-sh-sy5y-cells-by%C3%A2-enhancing-autophagy-via-sirtuin-1-deacetylation-of-the-rela-p65-subunit-of-nf-%C3%AE%C2%BAb
#19
Chutikorn Nopparat, Puritat Sinjanakhom, Piyarat Govitrapong
Autophagy, a degradation mechanism that plays a major role in maintaining cellular homeostasis and diminishes in aging, is considered an aging characteristic. Melatonin is an important hormone that plays a wide range of physiological functions, including the anti-aging effect, potentially via the regulation of the Sirtuin1 (SIRT1) pathway. The deacetylation ability of SIRT1 is important for controlling the function of several transcription factors, including nuclear factor kappa B (NF-ĸB). Apart from inflammation, NF-ĸB can regulate autophagy by inhibiting Beclin1, an initiator of autophagy...
August 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/28512916/regulation-of-bone-mass-through-pineal-derived-melatonin-mt2-receptor-pathway
#20
Kunal Sharan, Kirsty Lewis, Takahisa Furukawa, Vijay K Yadav
Tryptophan, an essential amino acid through a series of enzymatic reactions gives rise to various metabolites, viz. serotonin and melatonin, that regulate distinct biological functions. We show here that tryptophan metabolism in the pineal gland favors bone mass accrual through production of melatonin, a pineal-derived neurohormone. Pineal gland-specific deletion of Tph1, the enzyme that catalyzes the first step in the melatonin biosynthesis lead to a decrease in melatonin levels and a low bone mass due to an isolated decrease in bone formation while bone resorption parameters remained unaffected...
May 17, 2017: Journal of Pineal Research
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