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Journal of Pineal Research

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https://www.readbyqxmd.com/read/28719035/melatonin-inhibits-nucleus-pulposus-np-cell-proliferation-and-extracellular-matrix-ecm-remodeling-via-the-melatonin-membrane-receptors-mediated-pi3k-akt-pathway
#1
Zheng Li, Xingye Li, Chong Chen, Matthew T V Chan, William Ka Kei Wu, Jianxiong Shen
Pinealectomy in vertebrates accelerated intervertebral disc degeneration (IDD). However, the potential mechanisms, particularly, melatonin's role is still to be clarified. In this study, for first time, melatonin membrane receptors of MT1 and MT2 were found to be present in the human intervertebral disc tissues and nucleus pulposus (NP) cells, respectively. Melatonin treatment significantly inhibited NP cell proliferation in dose- dependent manner. Accordingly, melatonin down-regulated gene expression of cyclin D1, PCNA, matrix metallopeptidases-3 and -9 and upregulated gene expression of collagen type II alpha 1 chain and aggrecan in NP cells...
July 18, 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/28718992/melatonin-impedes-tet1-dependent-mglur5-promoter-demethylation-to-relieve-pain
#2
Ming-Chun Hsieh, Yu-Cheng Ho, Cheng-Yuan Lai, Dylan Chou, Hsueh-Hsiao Wang, Gin-Den Chen, Tzer-Bin Lin, Hsien-Yu Peng
Melatonin (N-acetyl-5-methoxytryptamine)/MT2 receptor-dependent epigenetic modification represents a novel pathway in the treatment of neuropathic pain. Because spinal ten-eleven translocation methylcytosine dioxygenase 1 (Tet1)-dependent epigenetic demethylation has recently been linked to pain hypersensitivity, we hypothesized that melatonin/MT2-dependent analgesia involves spinal Tet1-dependent demethylation. Here, we showed that spinal Tet1 gene transfer by intrathecal delivery of Tet1-encoding vectors to naïve rats produced profound and long-lasting nociceptive hypersensitivity...
July 18, 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/28708271/melatonin-protects-against-the-pathological-cardiac-hypertrophy-induced-by-transverse-aortic-constriction-through-activating-pgc-1%C3%AE-in-vivo-and-in-vitro-studies
#3
Mengen Zhai, Zhenhua Liu, Bin Zhang, Lin Jing, Buying Li, Kaifeng Li, Xiuju Chen, Meng Zhang, Bo Yu, Kai Ren, Yang Yang, Wei Yi, Jian Yang, Jincheng Liu, Dinghua Yi, Hongliang Liang, Zhenxiao Jin, Russel J Reiter, Weixun Duan, Shiqiang Yu
Melatonin, a circadian molecule secreted by the pineal gland, confers a protective role against cardiac hypertrophy induced by hyperthyroidism, chronic hypoxia and isoproterenol. However, its role against pressure overload-induced cardiac hypertrophy and the underlying mechanisms remain elusive. In this study, we investigated the pharmacological effects of melatonin on pathological cardiac hypertrophy induced by transverse aortic constriction (TAC). Male C57BL/6 mice underwent TAC or sham surgery at day 0 and were then treated with melatonin (20 mg/kg/day, via drinking water) for 4 or 8 weeks...
July 14, 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/28708259/rapid-modulation-of-the-silent-information-regulator-1-sirt1-by-melatonin-after-hypoxia-ischemia-in-the-neonatal-rat-brain
#4
Silvia Carloni, Giulia Riparini, Giuseppe Buonocore, Walter Balduini
Increasing evidence indicates that melatonin possesses protective effects toward different kinds of damage in various organs, including the brain. In a neonatal model of hypoxia-ischemia (HI), melatonin was neuroprotective and preserved the expression of the Silent Information Regulator 1 (SIRT1) 24h after the insult. This study aimed to gain more insight into the role of SIRT1 in the protective effect of melatonin after HI by studying the early (1h) modulation of SIRT1 and its downstream targets, and the consequences on necrosis, apoptosis, autophagy and glial cell activation...
July 14, 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/28658527/melatonin-protects-against-maternal-obesity-associated-oxidative-stress-and-meiotic-defects-in-oocytes-via-the-sirt3-sod2-dependent-pathway
#5
Longsen Han, Haichao Wang, Ling Li, Xiaoyan Li, Juan Ge, Russel J Reiter, Qiang Wang
Maternal obesity in humans is associated with poor outcomes across the reproductive spectrum. Emerging evidence indicates that these defects are likely attributed to factors within the oocyte. Although various molecules and pathways may contribute to impaired oocyte quality, prevention of fertility issues associated with maternal obesity is a challenge. Using mice fed a high-fat diet (HFD) as an obesity model, we document spindle disorganization, chromosome misalignment, and elevated reactive oxygen species (ROS) levels in oocytes from obese mice...
June 28, 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/28658519/synergistic-effect-of-melatonin-and-ghrelin-in-preventing-cisplatin-induced-ovarian-damage-via-regulation-of-foxo3a-phosphorylation-and-binding-to-the-p27-kip1-promoter-in-primordial-follicles
#6
Hoon Jang, Younghwa Na, Kwonho Hong, Sangho Lee, Sohyeon Moon, Minha Cho, Miseon Park, Ok-Hee Lee, Eun Mi Chang, Dong Ryul Lee, Jung Jae Ko, Woo Sik Lee, Youngsok Choi
Premature ovarian failure during chemotherapy is a serious problem for young women with cancer. To preserve the fertility of these patients, approaches to prevent chemotherapy-induced ovarian failure are needed. In a previous study, we reported that melatonin treatment prevents the depletion of the dormant follicle pool via repression of the simultaneous activation of dormant primordial follicles by cisplatin. However, melatonin's protective effect was only partial and thus insufficient. In this study, we found that the hormone ghrelin enhances the protective effect of melatonin against cisplatin-induced ovarian failure in mouse model...
June 28, 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/28658514/the-role-and-therapeutic-potential-of-melatonin-in-age-related-ocular-diseases
#7
REVIEW
Almudena Crooke, Fernando Huete-Toral, Basilio Colligris, Jesús Pintor
The eye is continuously exposed to solar UV radiation and pollutants, making it prone to oxidative attacks. In fact, oxidative damage is a major cause of age-related ocular diseases including cataract, glaucoma, age-related macular degeneration and diabetic retinopathy. Since the nature of lens cells, trabecular meshwork cells, retinal ganglion cells, retinal pigment epithelial cells and photoreceptors is post-mitotic, autophagy plays a critical role in their cellular homeostasis. In age-related ocular diseases, this process is impaired, thus, oxidative damage becomes irreversible...
June 28, 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/28599069/plant-mitochondria-synthesize-melatonin-and-enhance-the-tolerance-of-plants-to-drought-stress
#8
Lin Wang, Chao Feng, Xiaodong Zheng, Yan Guo, Fangfang Zhou, Dongqian Shan, Xuan Liu, Jin Kong
Synthesis of melatonin in mitochondria was reported in animals. However, there is no report on whether plant mitochondria also produce melatonin. Herein, we show that plant mitochondria are a major site for melatonin synthesis. In an in vitro study, isolated apple mitochondria had the capacity to generate melatonin. Subcellular localization analysis documented that an apple SNAT isoform, MzSNAT5, was localized in the mitochondria of both Arabidopsis protoplasts and apple callus cells. The kinetic analysis revealed that the recombinant MzSNAT5 protein exhibited high enzymatic activity to catalyze serotonin to N-acetylserotonin with the Km and Vmax of 55 μM and 0...
June 9, 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/28580724/melatonin-delays-photoreceptor-degeneration-in-a-mouse-model-of-autosomal-recessive-retinitis-pigmentosa
#9
Xiao-Jian Xu, Shu-Min Wang, Ying Jin, Yun-Tao Hu, Kang Feng, Zhi-Zhong Ma
Retinitis pigmentosa (RP) comprises a group of incurable inherited retinal degenerations. Targeting common processes, instead of mutation specific treatment, has proven to be an innovative strategy to combat debilitating retinal degeneration. Growing evidence indicates that melatonin possesses a potent activity against neurodegenerative disorders by mitigating cell damage associated with apoptosis and inflammation. Given the pleiotropic role of melatonin in central nervous system, the aim of the present study was to investigate whether melatonin would afford protection against retinal degeneration in autosomal recessive RP (arRP)...
June 5, 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/28580641/melatonin-reduces-endoplasmic-reticulum-stress-and-corneal-dystrophy-associated-tgfbip-through-activation-of-endoplasmic-reticulum-associated-protein-degradation
#10
Seung-Il Choi, Eunhee Lee, Begum Akuzum, Jang Bin Jeong, Yong-Sun Maeng, Tae-Im Kim, Eung Kweon Kim
Endoplasmic reticulum (ER) stress is emerging as a factor for the pathogenesis of granular corneal dystrophy type 2 (GCD2). This study was designed to investigate the molecular mechanisms underlying the protective effects of melatonin on ER stress in GCD2. Our results showed that GCD2 corneal fibroblasts were more susceptible to ER stress-induced death than were wild-type cells. Melatonin significantly inhibited GCD2 corneal cell death, caspase-3 activation, and poly (ADP-ribose) polymerase 1 cleavage caused by the ER stress inducer, tunicamycin...
June 5, 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/28580603/enhancement-of-high-glucose-induced-pink1-expression-by-melatonin-stimulates-neuronal-cell-survival-involvement-of-mt2-akt-nf-%C3%AE%C2%BAb-pathway
#11
Xaykham Onphachanh, Hyun Jik Lee, Jae Ryong Lim, Young Hyun Jung, Jun Sung Kim, Chang Woo Chae, Sei-Jung Lee, Amr Ahmed Gabr, Ho Jae Han
Hyperglycemia is a representative hallmark and risk factor for diabetes mellitus (DM) and is closely linked to DM-associated neuronal cell death. Previous investigators reported on a genome-wide association study and showed relationships between DM and melatonin receptor (MT), highlighting the role of MT signaling by assessing melatonin in DM. However, the role of MT signaling in DM pathogenesis is unclear. Therefore, we investigated the role of mitophagy regulators in high glucose-induced neuronal cell death and the effect of melatonin against high glucose-induced mitophagy regulators in neuronal cells...
June 5, 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/28512916/regulation-of-bone-mass-through-pineal-derived-melatonin-mt2-pathway
#12
Kunal Sharan, Kirsty Lewis, Takahisa Furukawa, Vijay K Yadav
Tryptophan, an essential amino acid through a series of enzymatic reactions gives rise to various metabolites viz., serotonin and melatonin that regulate distinct biological functions. We show here that tryptophan metabolism in the pineal gland favors bone mass accrual through production of melatonin, a pineal-derived neurohormone. Pineal gland-specific deletion of Tph1, the enzyme that catalyzes the first step in the melatonin biosynthesis lead to a decrease in melatonin levels and a low bone mass due to an isolated decrease in bone formation while bone resorption parameters remained unaffected...
May 17, 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/28512846/melatonin-influences-the-sonic-hedgehog-signaling-pathway-in-porcine-cumulus-oocyte-complexes
#13
Sanghoon Lee, Jun-Xue Jin, Anukul Taweechaipaisankul, Geon A Kim, Curie Ahn, Byeong Chun Lee
Melatonin, which is synthesized in the pineal gland and peripheral reproductive organs, has antioxidant properties and regulates physiological processes. It is well known that melatonin affects in vitro maturation (IVM) of oocytes and embryonic development in many species. However, beneficial effects of melatonin on IVM have been explained mainly by indirect antioxidant effects and little information is available on the underlying mechanism by which melatonin directly acts on porcine cumulus oocyte complexes (COCs)...
May 17, 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/28500782/melatonin-protects-bone-marrow-mesenchymal-stem-cells-against-iron-overload-induced-aberrant-differentiation-and-senescence
#14
Fan Yang, Lei Yang, Yuan Li, Gege Yan, Chao Feng, Tianyi Liu, Rui Gong, Ye Yuan, Ning Wang, Elina Idiiatullina, Timur Bikkuzin, Valentin Pavlov, Yang Li, Chaorun Dong, Dawei Wang, Yang Cao, Zhenbo Han, Lai Zhang, Qi Huang, Fengzhi Ding, Zhengang Bi, Benzhi Cai
Bone marrow mesenchymal stem cells (BMSCs) are an expandable population of stem cells which can differentiate into osteoblasts, chondrocytes and adipocytes. Dysfunction of BMSCs in response to pathological stimuli contributes to bone diseases. Melatonin, a hormone secreted from pineal gland, has been proved to be an important mediator in bone formation and mineralization. The aim of this study was to investigate whether melatonin protected against iron overload-induced dysfunction of BMSCs and its underlying mechanisms...
May 13, 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/28500770/the-role-of-melatonin-in-the-neurodevelopmental-etiology-of-schizophrenia-a-study-in-human-olfactory-neuronal-precursors
#15
Tania Galván-Arrieta, Citlali Trueta, Montserrat G Cercós, Marcela Valdés-Tovar, Salvador Alarcón, Julian Oikawa, Horacio Zamudio-Meza, Gloria Benítez-King
Dim light exposure of the mother during pregnancy has been proposed as one of the environmental factors that affect the fetal brain development in schizophrenia. Melatonin circulating levels are regulated by the environmental light/dark cycle. This hormone stimulates neuronal differentiation in the adult brain. However, little is known about its role in the fetal human brain development. Olfactory neuronal precursors (ONPs) are useful for studying the physiopathology of neuropsychiatric diseases because they mimic all the stages of neurodevelopment in culture...
May 13, 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/28500766/melatonin-inhibits-neuronal-dysfunction-associated-with-neuroinflammation-by-atopic-psychological-stress-in-nc-nga-atopic-like-mouse-models
#16
Gunhyuk Park, Seung Hoon Lee, Dal-Seok Oh, Yong-Ung Kim
Atopic dermatitis (AD), also known as atopic eczema, is chronic pruritic skin disease. AD can increase psychological stress as well, increasing glucocorticoid release and exacerbating the associated symptoms. Chronic glucocorticoid elevation disturbs neuroendocrine signaling, and can induce neuroinflammation, neurotoxicity, and cognitive impairment; however, it is unclear if AD-related psychological stress elevates glucocorticoids enough to cause neuronal damage. Therefore, we assessed the effects of AD-induced stress in a mouse AD model...
May 13, 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/28500761/melatonin-ameliorates-myocardial-ischemia-reperfusion-injury-through-sirt3-dependent-regulation-of-oxidative-stress-and-apoptosis
#17
Mengen Zhai, Buying Li, Weixun Duan, Lin Jing, Bin Zhang, Meng Zhang, Liming Yu, Zhenhua Liu, Bo Yu, Kai Ren, Erhe Gao, Yang Yang, Hongliang Liang, Zhenxiao Jin, Shiqiang Yu
Sirtuins are a family of highly evolutionarily conserved nicotinamide adenine nucleotide-dependent histone deacetylases. Sirtuin-3 (SIRT3) is a member of the sirtuin family that is localized primarily to the mitochondria and protects against oxidative stress-related diseases, including myocardial ischemia/reperfusion (MI/R) injury. Melatonin has a favorable effect in ameliorating MI/R injury. We hypothesized that melatonin protects against MI/R injury by activating the SIRT3 signaling pathway. In this study, mice were pretreated with or without a selective SIRT3 inhibitor and then subjected to MI/R operation...
May 13, 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/28480597/melatonin-protects-against-diabetic-cardiomyopathy-through-mst1-sirt3-signaling
#18
Mingming Zhang, Jie Lin, Shanjie Wang, Zheng Cheng, Jianqiang Hu, Tingting Wang, Wanrong Man, Tao Yin, Wenyi Guo, Erhe Gao, Russel J Reiter, Haichang Wang, Dongdong Sun
The present study investigated the effects of melatonin on diabetic cardiomyopathy (DCM) and determined the underlying mechanisms. Echocardiography indicated that melatonin notably mitigated the adverse left ventricle remodeling and alleviated cardiac dysfunction in DCM. The mechanisms were attributed to increased autophagy, reduced apoptosis and alleviated mitochondrial dysfunction. Furthermore, melatonin inhibited Mst1 phosphorylation and promoted Sirt3 expression in DCM. These results indicated that melatonin may exert its effects through Mst1/ Sirt3 signaling...
May 8, 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/28480587/melatonin-successfully-rescues-hippocampal-bioenergetics-and-improves-cognitive-function-following-drug-intoxication-by-promoting-nrf2-are-signaling-activity
#19
Li-You Chen, Ting-Yi Renn, Wen-Chieh Liao, Fu-Der Mai, Ying-Jui Ho, George Hsiao, Ai-Wei Lee, Hung-Ming Chang
Prolonged exposure to gamma-hydroxybutyric acid (GHB) would cause drug intoxication in which impaired cognitive function results from enhanced hippocampal oxidative stress may serve as a major symptom in this deficiency. Considering melatonin possesses significant anti-oxidative efficacy, this study aimed to determine whether melatonin would successfully promote the nuclear factor erythroid 2-related factor 2 and antioxidant responsive element (Nrf2-ARE) signaling, depress oxidative stress, and rescue hippocampal bioenergetics and cognitive function following drug intoxication injury...
May 8, 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/28226188/effects-of-melatonin-on-seedling-growth-mineral-nutrition-and-nitrogen-metabolism-in-cucumber-under-nitrate-stress
#20
Ruimin Zhang, Yunkuo Sun, Zeyu Liu, Wen Jin, Yan Sun
In China, excessive use of nitrogen fertilizers in glasshouses leads to nitrate accumulations in soil and plants, which then limits productivity. Melatonin, an evolutionarily highly conserved molecule, has a wide range of functions in plants. We analyzed the effects of melatonin pretreatment on the growth, mineral nutrition, and nitrogen metabolism in cucumber (Cucumis sativus L. "Jin You No. 1") when seedlings were exposed to nitrate stress. An application of 0.1 mmol/L melatonin significantly improved the growth of plants and reduced their susceptibility to damage due to high nitrate levels (0...
May 2017: Journal of Pineal Research
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