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European Journal of Surgical Oncology

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https://www.readbyqxmd.com/read/28202211/the-risk-of-postoperative-complications-and-functional-impairment-after-multimodality-treatment-for-limb-and-trunk-wall-soft-tissue-sarcoma-long-term-results-from-a-monocentric-series
#1
E Stoeckle, A Michot, L Rigal, F Babre, P Sargos, B Henriques de Figueiredo, V Brouste, A Italiano, M Toulmonde, F Le Loarer, M Kind
BACKGROUND AND OBJECTIVES: Conservative surgery for soft-tissue sarcoma (STS) within multimodality treatment attempts to reconcile two contradictory requirements: assuring a good oncological outcome through a wide resection and preserving the function. The aim of our study is to verify whether our conservative approach to STS met these objectives. METHODS: A retrospective database analysis was performed in adults with primary limb or trunk wall STS operated in a single center from 1989 to 2012...
February 3, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28209329/prognostic-factors-of-hemorrhagic-complications-after-oxaliplatin-based-hyperthermic-intraperitoneal-chemotherapy-toward-routine-preoperative-dosage-of-von-willebrand-factor
#2
J-B Delhorme, L Sattler, F Severac, E Triki, I Gross, B Romain, S Rohr, L Grunebaum, C Brigand
BACKGROUND: Oxaliplatin-based hyperthermic intraperitoneal chemotherapy (HIPEC-ox) induces specific morbidity with hemorrhagic complications (HC). The aim of this study was to identify preoperative, intraoperative and postoperative HC predictive factors after HIPEC-ox. METHODS: A prospective single center study that included all consecutive patients treated with curative-intent HIPEC-ox, whatever the origin of peritoneal disease, was conducted. All patients underwent systematic blood tests exploring primary hemostasis and endothelial activation before surgical incision (D0) and on postoperative days 2 (POD2) and 5 (POD5)...
February 2, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28209239/decreased-reg1%C3%AE-expression-suppresses-growth-invasion-and-angiogenesis-of-bladder-cancer
#3
J Geng, J Fan, Q Wang, X-P Zhang, L Kang, Q-Y Li, Y-F Xu, B Peng, J-H Zheng, X-D Yao
BACKGROUND: Previous study has indicated association between REG1α and bladder cancer. The aim of this study was to investigate the role of Regenerating gene I alpha (REG1α) in bladder cancer. METHODS: The role of REG1α in bladder cancer cell proliferation, migration and VEGF-induced angiogenesis was explored in vitro and in vivo. Immunohistochemistry (IHC) analysis was assessed to determine the expression of REG1α in ten paired bladder cancer and adjacent non-cancerous tissues, and in 296 bladder cancer samples...
February 2, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28214053/standardization-of-oncoplastic-breast-conserving-surgery
#4
REVIEW
W P Weber, S D Soysal, I Fulco, M Barandun, D Babst, D Kalbermatten, D J Schaefer, D Oertli, E A Kappos, M Haug
The emphasis on esthetic outcomes and quality of life after breast cancer surgery has motivated surgeons to develop oncoplastic breast conserving surgery (OPS). Training programs are still rare in most countries, and there is little standardization, which challenges the scientific evaluation of the techniques. The present article attempts to standardize OPS nomenclature, indications, and reconstruction choice selection embedded in a thorough review of the literature. We propose four breast conserving surgery (BCS) categories: Conventional tumorectomy, oncoplastic mastopexy, oncoplastic tumorectomy and oncoplastic reduction mammoplasty...
January 31, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28214052/high-tumor-infiltrating-foxp3-t-cells-predict-poor-survival-in-estrogen-receptor-positive-breast-cancer-a-meta-analysis
#5
F Qian, Y Qingping, W Linquan, H Xiaojin, W Rongshou, R Shanshan, L Wenjun, H Yong, L Enliang
AIMS: Tumor-infiltrating FoxP3(+) T cells and FoxP3(+) tumor cells have been reported in breast cancer (BC), which impaired immunity and promoted tumors progression. However, their prognostic value for survival in patients with breast BC remains controversial. METHODS: A meta-analysis was performed. Original data included the hazard ratios (HR) of overall survival (OS), relapse-free survival and odds ratio (OR) in BC patients. We pooled HR/OR with 95% confidence intervals (CI) to estimate the hazard...
January 30, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28189456/long-term-regional-chemotherapy-for-patients-with-epithelial-malignant-peritoneal-mesothelioma-results-in-improved-survival
#6
REVIEW
P H Sugarbaker, D Chang
PURPOSE: Malignant peritoneal mesothelioma (MPM) is a rare disease with about 300 new cases per year in the USA. Its natural history is described as local progression within the peritoneal space in the absence of liver metastases or systemic disease. METHODS: Cytoreductive surgery (CRS) is a series of peritonectomy procedures and visceral resections with a goal of complete removal of all visible disease from the abdomen and pelvis. Over 20 years, three protocols investigating increasing efficacy of additional chemotherapy treatments added to CRS have been initiated...
January 29, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28187878/embryonic-origin-of-primary-colon-cancer-predicts-survival-in-patients-undergoing-ablation-for-colorectal-liver-metastases
#7
S Yamashita, B C Odisio, S Y Huang, S E Kopetz, K Ahrar, Y S Chun, C Conrad, T A Aloia, S Gupta, S Harmoush, M E Hicks, J-N Vauthey
BACKGROUND: In patients with primary colorectal cancer (CRC) or unresectable metastatic CRC, midgut embryonic origin is associated with worse prognosis. The impact of embryonic origin on survival after ablation of colorectal liver metastases (CLM) is unclear. METHODS: We identified 74 patients with CLM who underwent percutaneous ablation during 2004-2015. Survival and recurrence after ablation of CLM from midgut origin (n = 18) and hindgut origin (n = 56) were analyzed...
January 29, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28187877/timing-of-initiation-of-adjuvant-chemotherapy-for-gastric-cancer-a-case-matched-comparison-study-of-laparoscopic-vs-open-surgery
#8
A Kaito, T Kinoshita, K Shitara, H Shibasaki, T Nishida
BACKGROUND: Laparoscopic gastrectomy (LG) is reported to be associated with faster recovery than open gastrectomy (OG); however, the influence of the surgical approach on initiation timing of adjuvant chemotherapy (AC) remains unclear. METHODS: This was a single-institutional retrospective observational study. Patients with pathological stage II/III gastric cancer undergoing LG with D2 lymphadenectomy (LG group: n = 74) were matched 1:1 with patients selected from 214 similar patients undergoing OG (OG group: n = 74), identically matching gender, age, pathological stage, and type of gastrectomy, and comparing AC initiation timing between the two groups...
January 29, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28185687/circulating-tumor-cells-and-circulating-tumor-dna-what-surgical-oncologists-need-to-know
#9
REVIEW
L Cabel, C Proudhon, P Mariani, D Tzanis, G Beinse, I Bieche, J-Y Pierga, F-C Bidard
As a result of recent progress in detection techniques, circulating tumor DNA (ctDNA) and circulating tumor cells (CTC) can now be accurately detected in the blood of most cancer patients. While these new biomarkers can provide a better understanding of key biological mechanisms underlying cancer growth and dissemination, they also open up a wide range of possible clinical applications in medical oncology, radiation oncology and surgical oncology. In this review, we summarize the results obtained with ctDNA and CTC together with their potential future clinical applications in the field of surgical oncology, with particular focus on the perioperative setting of various types of cancer...
January 29, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28148464/complication-related-removal-of-totally-implantable-venous-access-port-systems-do-not-forget-the-skin-scar-in-survivors
#10
LETTER
S Gaucher, A Martin, I Benachour, D Maladry, J-M Tigaud, F Goldwasser, H-J Philippe
No abstract text is available yet for this article.
January 24, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28189455/evaluation-of-the-robotic-approach-concerning-pitfalls-in-rectal-surgery
#11
J K Baukloh, M Reeh, G Spinoglio, A Corratti, I Bartolini, V M Mirasolo, F Priora, J R Izbicki, M Gomez Fleitas, M Gomez Ruiz, D R Perez
INTRODUCTION: The feasibility and advantages of robotic rectal surgery (RRS) in comparison to conventional open or laparoscopic rectal resections have been postulated in several reports. But well-known challenges and pitfalls of minimal invasive rectal surgery have not been evaluated by a prospective, multicenter setting so far. Aim of this study was to analyze the perioperative outcome of patients following RRS especially in regard to the pitfalls such as obesity, male patients and low tumors by a European multicenter setting...
January 19, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28162818/efficacy-of-preoperative-immunonutrition-in-locally-advanced-pancreatic-cancer-undergoing-irreversible-electroporation-ire
#12
R C G Martin, S Agle, M Schlegel, T Hayat, C R Scoggins, K M McMasters, P Philips
BACKGROUND: Improved preoperative immunonutrition has been shown to decrease the length of stay (LOS) and complications among patients undergoing elective gastrointestinal cancer surgeries. The purpose of this study was to determine whether preoperative immunonutrition supplementation decreases postoperative LOS, infectious complications, and morbidity in patients undergoing irreversible electroporation (IRE) surgery for locally advanced pancreatic cancer (LAPC). METHODS: At a regional hepatopancreatobiliary referral center within an academic medical center 71 patients receiving IRE treatment of LAPC were included in the study...
January 19, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28159443/the-influence-of-sarcopenia-on-survival-and-surgical-complications-in-ovarian-cancer-patients-undergoing-primary-debulking-surgery
#13
I J G Rutten, J Ubachs, R F P M Kruitwagen, D P J van Dijk, R G H Beets-Tan, L F A G Massuger, S W M Olde Damink, T Van Gorp
BACKGROUND: Sarcopenia, severe skeletal muscle loss, has been identified as a prognostic factor in various malignancies. This study aims to investigate whether sarcopenia is associated with overall survival (OS) and surgical complications in patients with advanced ovarian cancer undergoing primary debulking surgery (PDS). METHODS: Ovarian cancer patients (n = 216) treated with PDS were enrolled retrospectively. Total skeletal muscle surface area was measured on axial computed tomography at the level of the third lumbar vertebra...
January 19, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28139363/surgical-management-of-primary-thyroid-tumours
#14
P Asimakopoulos, I J Nixon
The majority of patients who present with well differentiated thyroid cancer will require surgery, but decisions on the appropriate primary procedure will depend on information relating to patient, tumour and surgical factors. As the incidence of thyroid cancer continues to rise, it is critical that clinicians involved in the management of these cases understand the factors which underpin surgical decision making for individual patients. Reporting outcomes in well differentiated thyroid cancer (WDTC) has always been challenging due to the low recurrence and mortality rate of the disease...
January 19, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28132788/prognostic-heterogeneity-of-the-seventh-edition-of-uicc-stage-iii-gallbladder-carcinoma-which-patients-benefit-from-surgical-resection
#15
J Sakata, T Kobayashi, T Ohashi, Y Hirose, K Takano, K Takizawa, K Miura, H Ishikawa, K Toge, K Yuza, D Soma, T Ando, T Wakai
BACKGROUND: This study sought to evaluate the prognostic heterogeneity of Stage III (Union for International Cancer Control, seventh edition) gallbladder carcinoma. METHODS: Of 175 patients enrolled with gallbladder carcinoma who underwent radical resection, 22 were classified with Stage IIIA disease (T3N0M0) and 46 with Stage IIIB disease (T2N1M0 [n = 23] and T3N1M0 [n = 23]). The median number of retrieved lymph nodes per patient was 18. RESULTS: This staging system failed to stratify outcomes between Stages IIIA and IIIB; survival after resection was better for patients with Stage IIIB disease than for patients with Stage IIIA disease, with 5-year survival of 54...
January 19, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28139361/is-intraoperative-touch-imprint-cytology-indicated-in-the-surgical-treatment-of-early-breast-cancers
#16
Z Horváth, A Paszt, Z Simonka, M Látos, V Oláh, D Nagyszegi, L Kaizer, Z Fejes, S Hamar, E Csörgő, K Ormándi, M Lázár, G Lázár
INTRODUCTION: Intraoperative touch imprint cytology (TIC) of the sentinel lymph node(s) (SLN(s)) in the treatment of breast cancer has significantly reduced the number of axillary block dissections (ABD) required during second surgeries. Based on recent studies, ABD was not considered necessary if the presence of tumor cells/micrometastasis was confirmed in the SLN(s) or in the case of macrometastases in a patient group meeting the inclusion criteria for the ACOSOG Z0011 study. Our aim was to determine the sensitivity and usefulness of TIC with regard to these results...
January 18, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28132787/safety-and-efficacy-of-laparoscopic-wedge-gastrectomy-for-large-gastrointestinal-stromal-tumors
#17
M Milone, U Elmore, M Musella, P Parise, M C Zotti, U Bracale, K Di Lauro, M Manigrasso, F Milone, R Rosati
BACKGROUND: Although the feasibility of minimally invasive resection of small gastric GISTs is well established, less is known about safety and efficacy of laparoscopic surgery for large tumors. METHODS: A retrospective analysis was performed, using a prospectively maintained comprehensive database. Patients were divided into two groups according to tumor size: Case group with tumors > 5 cm and control group with tumors <5 cm. Hospital charts were reviewed, and various outcome measures recorded, including operative time, estimated operative blood loss, post-operative leak, stasis, infection and recurrence...
January 18, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28131669/-what-if-i-do-nothing-the-natural-history-of-operable-cancer-of-the-alimentary-tract
#18
H B Keshava, J E Rosen, M R DeLuzio, A W Kim, F C Detterbeck, D J Boffa
INTRODUCTION: "Natural history", or anticipated survival without treatment, is critical for patients weighing risks and benefits of cancer surgery. Current estimates concerning the natural history of cancer includes patients whose poor health precludes treatment; a cohort whose fate is likely distinctly worse than those eligible for surgery ("operable"). The study objective was to evaluate survival among patients recommended for cancer surgery but went untreated, to determine the natural history of "operable" alimentary tract cancer...
January 18, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28139362/eight-year-follow-up-result-of-the-otoasor-trial-the-optimal-treatment-of-the-axilla-surgery-or-radiotherapy-after-positive-sentinel-lymph-node-biopsy-in-early-stage-breast-cancer-a-randomized-single-centre-phase-iii-non-inferiority-trial
#19
Á Sávolt, G Péley, C Polgár, N Udvarhelyi, G Rubovszky, E Kovács, B Győrffy, M Kásler, Z Mátrai
INTRODUCTION: The National Institute of Oncology, Budapest conducted a single centre randomized clinical study. The OTOASOR (Optimal Treatment Of the Axilla - Surgery Or Radiotherapy) trial compares completion of axillary lymph node dissection (cALND) to regional nodal irradiation (RNI) in patients with sentinel lymph node metastasis (pN1sn) in stage I-II breast cancer. PATIENTS AND METHODS: Patients with primary invasive breast cancer (cN0 and cT ≤ 3 cm) were randomized before surgery for cALND (standard treatment) or RNI (investigational treatment)...
January 16, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28131670/clinical-results-of-stereotactic-body-radiotherapy-sbrt-in-the-treatment-of-isolated-local-recurrence-of-pancreatic-cancer-after-r0-surgery-a-retrospective-study
#20
T Comito, L Cozzi, A Zerbi, C Franzese, E Clerici, A Tozzi, C Iftode, P Navarria, G D'Agostino, A Fogliata, P Mancosu, S Tomatis, C Carnaghi, N Personeni, A Santoro, M Scorsetti
OBJECTIVE: To evaluate the efficacy and the feasibility of SBRT for selected patients with isolated local recurrence of pancreatic cancer after radical surgery. METHODS: A retrospective analysis was performed on patients treated with SBRT for isolated local recurrence from resected pancreatic adenocarcinoma, after multidisciplinary board evaluation. Prescription dose was 45 Gy in 6 fractions for all patients. Primary end-point was freedom from local progression (FFLP)...
January 16, 2017: European Journal of Surgical Oncology
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