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European Journal of Surgical Oncology

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https://www.readbyqxmd.com/read/28062160/loss-of-secreted-frizzled-related-protein-1-expression-is-associated-with-poor-prognosis-in-intrahepatic-cholangiocarcinoma
#1
M Davaadorj, Y Saito, Y Morine, T Ikemoto, S Imura, C Takasu, S Yamada, T Hiroki, M Yoshikawa, M Shimada
AIMS: Secreted Frizzled-Related Protein-1 (SFRP1) is a well-known negative regulator of the wingless type (Wnt)-β-catenin pathway and its inactivation plays an important role in the development and progression of many cancers. In this study, we aimed to determine the clinical significance of SFRP1 expression in intrahepatic cholangiocarcinoma (IHCC) and to define the relationship to Wnt-β-catenin pathway. METHODS: Fifty IHCC patients who had liver resection were enrolled in this study...
December 24, 2016: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28069399/costs-and-resource-use-following-defunctioning-stoma-in-low-anterior-resection-for-cancer-a-long-term-analysis-of-a-randomized-multicenter-trial
#2
H Floodeen, O Hallböök, L A Hagberg, P Matthiessen
BACKGROUND: Defunctioning stoma in low anterior resection (LAR) for rectal cancer can prevent major complications, but overall cost-effectiveness for the healthcare provider is unknown. This study compared inpatient healthcare resources and costs within 5 years of LAR between two randomized groups of patients undergoing LAR with and without defunctioning stoma. METHOD: Five-year follow-up of a randomized, multicenter trial on LAR (NCT 00636948) with (stoma; n = 116) or without (no stoma; n = 118) defunctioning stoma comparing inpatient healthcare resources and costs...
December 21, 2016: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28041649/development-of-a-nomogram-for-predicting-the-risk-of-anastomotic-leakage-after-a-gastrectomy-for-gastric-cancer
#3
R-H Tu, J-X Lin, C-H Zheng, P Li, J-W Xie, J-B Wang, J Lu, Q-Y Chen, L-L Cao, M Lin, C-M Huang
AIMS: To investigate the incidence of and factors associated with anastomotic leakage (AL) following gastrectomy for gastric cancer. METHODS: We retrospectively analyzed 3632 patients who underwent a laparoscopic gastrectomy or open gastrectomy for gastric cancer. A logistic regression model was used to identify the determinant variables, and a nomogram for AL was developed. RESULTS: A total of 3632 patients were included in the study, 50 of whom (1...
December 20, 2016: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28041648/short-term-safety-of-oncoplastic-breast-conserving-surgery-for-larger-tumors
#4
D J Wijgman, B Ten Wolde, N R A van Groesen, M E Keemers-Gels, F J H van den Wildenberg, L J A Strobbe
BACKGROUND: Oncoplastic surgery (OPS) replaces lumpectomy as standard technique in breast conserving surgery (BCS). OPS has shown to give good cosmetic results, but is it as safe as standard lumpectomy? We conducted a retrospective cohort study to determine postoperative complications, resection margins and re-excision rates for OPS compared to standard lumpectomy. METHODS: Based on data from the 'Netherlands Cancer Registry' and medical records we scored patient, treatment and follow-up related variables...
December 18, 2016: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28040314/aesthetic-and-functional-outcome-after-breast-conserving-surgery-comparison-between-conventional-and-oncoplastic-resection
#5
K Ojala, T J Meretoja, M H K Leidenius
BACKGROUND: Recent studies implicate that oncoplastic breast cancer surgery provides better aesthetic outcome than conventional resection. Several factors have been associated with poor aesthetic outcome. This study aims to compare patient-reported aesthetic and functional outcome after conventional and oncoplastic resection and to evaluate prognostic factors for poor aesthetic outcome in a population-based setting. METHODS: 637 patients having breast conserving treatment (BCT) due to unilateral primary breast cancer at a single hospital district during 2010 were included...
December 18, 2016: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28040313/treatment-of-second-ipsilateral-breast-tumor-event-a-need-for-a-new-type-of-evidence-for-avoiding-mastectomy
#6
LETTER
M Trombetta, J-M Hannoun-Levi
No abstract text is available yet for this article.
December 18, 2016: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28034498/genomic-sequencing-and-precision-medicine-in-head-and-neck-cancers
#7
REVIEW
R C Hoesli, M L Ludwig, N L Michmerhuizen, A J Rosko, M E Spector, J C Brenner, A C Birkeland
Head and neck squamous cell carcinoma (HNSCC) remains a common and deadly disease. Historically, surgical and chemoradiation treatments have been met with modest success, and understanding of genetic drivers of HNSCC has been limited. With recent next generation sequencing studies focused on HNSCC, we are beginning to understand the genetic landscape of HNSCCs and are starting to identify and advance targeted options for patients. In this review, we describe current knowledge and recent advances in sequencing studies of HNSCC, discuss current limitations and future directions for further genomic analysis, and highlight the translational advances being undertaken to treat this important disease...
December 15, 2016: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28087099/prognostic-and-predictive-indicators-in-early-stage-breast-cancer-and-the-role-of-genomic-profiling-focus-on-the-oncotype-dx-%C3%A2-breast-recurrence-score-assay
#8
E Curtit, L Mansi, Y Maisonnette-Escot, J-L Sautière, X Pivot
Although useful prognostic and predictive insights can be gained from patient and tumour characteristics in early-stage breast cancer, it is not always straightforward to predict the likely risk of recurrence for each individual patient following breast surgery. One of the most difficult challenges faced by clinicians is identifying patients who may benefit most from adjuvant chemotherapy, and distinguishing these cases from those where endocrine therapy may be sufficient for cure. Genomic tests such as the Oncotype DX(®) Breast Recurrence Score(®) Assay have been developed to provide a robust and clinically validated assessment of a patient's individual tumour signature...
December 14, 2016: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28034501/prognostic-significance-of-preoperative-inflammatory-response-biomarkers-in-patients-undergoing-curative-thoracoscopic-esophagectomy-for-esophageal-squamous-cell-carcinoma
#9
N Hirahara, T Matsubara, D Kawahara, S Nakada, S Ishibashi, Y Tajima
BACKGROUND: Recent studies have revealed significant relationships between the lymphocyte-to-monocyte ratio (LMR), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) and survival in various cancers. The purpose of this study was to confirm whether the LMR, NLR, and PLR have prognostic values, independent of clinicopathological criteria, in patients undergoing curative resection for esophageal cancer. METHODS: The LMR, NLR and PLR were calculated in 147 consecutive patients who underwent curative esophagectomy between January 2006 and December 2014...
December 14, 2016: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28034500/introduction-to-the-special-issue-of-european-journal-of-surgical-oncology-new-roads-in-melanoma-management
#10
EDITORIAL
P Rutkowski
No abstract text is available yet for this article.
December 14, 2016: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28024944/impact-of-sarcopenia-on-outcome-in-patients-with-esophageal-resection-following-neoadjuvant-chemotherapy-for-esophageal-cancer
#11
M Paireder, R Asari, I Kristo, E Rieder, D Tamandl, A Ba-Ssalamah, S F Schoppmann
BACKGROUND: Nutritional status and body composition parameters such as sarcopenia are important risk factors for impaired outcome in patients with esophageal cancer. This study was conducted to evaluate the effect of sarcopenia on long-term outcome after esophageal resection following neoadjuvant treatment. METHODS: Skeletal muscle index (SMI) and body composition parameters were measured in patients receiving neoadjuvant treatment for locally advanced esophageal cancer...
December 14, 2016: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28057391/regional-lymph-node-involvement-in-patients-undergoing-liver-resection-for-colorectal-cancer-metastases
#12
S Nanji, M E Tsang, X Wei, C M Booth
BACKGROUND: While the indications for surgery among patients with colorectal cancer liver metastases (CRCLM) are expanding, the role of surgery in patients with hepatic lymph node involvement remains controversial. We report management and outcomes in a population-based cohort of patients undergoing hepatectomy with concomitant hepatic lymphadenectomy for CRCLM. METHODS: All cases of hepatectomy for CRCLM in the Canadian Province of Ontario from 2002 to 2009 were identified using the population-based Ontario Cancer Registry and linked electronic records of treatment...
December 13, 2016: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28034499/an-outlook-on-precision-surgery
#13
EDITORIAL
M E Lidsky, M I D'Angelica
No abstract text is available yet for this article.
December 13, 2016: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28017458/specific-adverse-events-are-associated-with-response-to-exemestane-therapy-in-postmenopausal-breast-cancer-patients-results-from-the-teamiia-study-boog2006-04
#14
D B Y Fontein, A Charehbili, J W R Nortier, H Putter, E Meershoek-Klein Kranenbarg, J R Kroep, S C Linn, C J H van de Velde
PURPOSE: In the adjuvant setting, specific adverse events (AEs) such as vasomotor symptoms (VMS) and musculoskeletal AEs are associated with relapse-free survival in aromatase inhibitor (AI)-treated patients. In the neoadjuvant setting, specific AEs may be associated with tumor response to AIs as well. METHODS: Between 2007 and 2012, 107 patients participated in the prospective TEAMIIA trial, a prospective, phase II trial investigating 6 months of neoadjuvant exemestane in patients with strongly ER-positive breast cancer...
December 10, 2016: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28057392/primary-retroperitoneal-soft-tissue-sarcoma-imaging-appearances-pitfalls-and-diagnostic-algorithm
#15
REVIEW
C Messiou, E Moskovic, D Vanel, C Morosi, R Benchimol, D Strauss, A Miah, H Douis, W van Houdt, S Bonvalot
Although retroperitoneal sarcomas are rare tumours, they can be encountered by a wide variety of clinicians as they can be incidental findings on imaging or present with non specific symptoms and signs. Surgical resection can offer hope of cure and patient outcomes are improved when patients are managed in high-volume specialist centers. Failure to recognize retroperitoneal sarcomas on imaging can lead to inappropriate management in inexperienced centers. Therefore it is critical that a diagnosis of retroperitoneal sarcoma should be considered in the differential diagnosis of a retroperitoneal mass with prompt referral to a soft tissue sarcoma unit...
December 9, 2016: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28081871/editorial-will-allps-pass-the-test-of-time
#16
EDITORIAL
D G Vass, H Z Malik
No abstract text is available yet for this article.
December 5, 2016: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28069398/objective-decision-making-between-conventional-and-oncoplastic-breast-conserving-surgery-or-mastectomy-an-aesthetic-and-functional-prospective-cohort-study
#17
D Pukancsik, P Kelemen, M Újhelyi, E Kovács, N Udvarhelyi, N Mészáros, I Kenessey, T Kovács, M Kásler, Z Mátrai
BACKGROUND: Breast-conserving surgery (BCS) is considered the standard treatment for early-stage breast cancer. However, fair to poor cosmetic outcomes following conventional BCS have been observed in as many as one-third of cases. The aim of this study was to determine the critical tumor-to-breast volume ratio for each quadrant of the breast beyond which conventional BCS would no longer offer acceptable cosmetic and functional results or satisfactory quality of life for the patient. METHODS: A prospective cohort study was performed between December 2011 and December 2013 involving 350 patients younger than 70 years with early-stage unifocal (T ≤ 30 mm) breast cancer who underwent wide excision and axillary sentinel lymph node biopsy followed by whole-breast irradiation...
December 5, 2016: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28024943/effects-of-ovarian-ablation-or-suppression-in-premenopausal-breast-cancer-a-meta-analysis-of-randomized-controlled-trials
#18
REVIEW
P Zhang, C-Z Li, G-M Jiao, J-J Zhang, H-P Zhao, F Yan, S-F Jia, B-S Hu, C-T Wu
BACKGROUND: The effect of ovarian ablation or suppression (OAS) in premenopausal women with breast cancer is controversial. The overall survival (OS), disease-free survival (DFS) and adverse event of OAS versus no OAS were compared. METHODS: A literature review of EMBASE, Web of Science, PUBMED, and Cochrane Library was conducted. The hazard ratio (HR) and 95% confidence interval (CI) for OS and DFS, as well as risk ratio (RR) and 95% CI for adverse events were evaluated...
December 5, 2016: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28017457/alpps-the-argument-for
#19
EDITORIAL
J P A Lodge
No abstract text is available yet for this article.
December 5, 2016: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28012715/hospital-costs-of-complications-after-esophagectomy-for-cancer
#20
L Goense, W A van Dijk, J A Govaert, P S N van Rossum, J P Ruurda, R van Hillegersberg
OBJECTIVE: The purpose of this study was to estimate the economic burden of postoperative complications after esophagectomy for cancer, in order to optimally allocate resources for quality improvement initiatives in the future. METHODS: A retrospective analysis of prospectively collected clinical and financial outcomes after esophageal cancer surgery in a tertiary referral center in the Netherlands was performed. Data was extracted from consecutive patients registered in the Dutch Upper GI Cancer Audit between 2011 and 2014 (n = 201)...
December 5, 2016: European Journal of Surgical Oncology
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