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European Journal of Surgical Oncology

Takashi Mizuno, Jordan M Cloyd, Diego Vicente, Kiyohiko Omichi, Yun Shin Chun, Scott E Kopetz, Dipen Maru, Claudius Conrad, Ching-Wei D Tzeng, Steven H Wei, Thomas A Aloia, Jean-Nicolas Vauthey
INTRODUCTION: Dorsophilia protein, mothers against decapentaplegic homolog 4 (SMAD4) is a key mediator in the transforming growth factor (TGF)-β signaling pathway and SMAD4 gene mutations are thought to play a critical role in colorectal cancer (CRC) progression. However, little is known about its influence on survival in patients undergoing resection for colorectal liver metastases (CLM). METHODS: Between 2005 and 2015, all patients with known SMAD4 mutation status who underwent resection of CLM were identified...
March 7, 2018: European Journal of Surgical Oncology
Kohei Oashi, Kenjiro Namikawa, Arata Tsutsumida, Akira Takahashi, Jun Itami, Hiroshi Igaki, Koji Inaba, Naoya Yamazaki
BACKGROUND: In patients with cutaneous angiosarcoma of the scalp and face, the validity of surgery remains controversial, because of the potentially diffuse nature of involvement and difficulty in obtaining negative margins. OBJECTIVE: To evaluate the survival benefit of surgery as a primary treatment. PATIENTS AND METHODS: Fifty-one patients with primary cutaneous angiosarcoma of the scalp and face presenting with locoregional involvement were referred to National Cancer Center Hospital, Tokyo, Japan, between May 1982 and March 2013...
March 6, 2018: European Journal of Surgical Oncology
C M S Hassing, T F Tvedskov, N Kroman, T L Klausen, J B Drejøe, J F Tvedskov, T-L Lambine, H Kledal, G Lelkaitis, L Langhans
BACKGROUND: Radioactive seed localisation (RSL) is a preoperative localisation method using a small titanium seed containing iodine-125. The method is increasingly applied for localising non-palpable lesions in the treatment of breast cancer. We believe that RSL has the potential to be used in various surgical specialties. The aim of this feasibility study was to test RSL as a preoperative localisation of non-palpable lymph nodes. METHODS: Between November 24, 2015 and October 26, 2016, 15 patients with suspicious lymph nodes on imaging were included in the study...
March 6, 2018: European Journal of Surgical Oncology
Joonas H Kauppila, Karl Wahlin, Pernilla Lagergren, Jesper Lagergren
PURPOSE: Centralization of surgery improves the survival following esophagectomy for cancer, but whether university hospital setting or surgeon volume influences the reoperation rates is unknown. We aimed to clarify whether hospital status or surgeon volume are associated with a risk of reoperation after esophagectomy. METHODS: Patients who underwent esophagectomy for esophageal cancer in 1987-2010 were identified from a population-based, nationwide Swedish cohort study...
March 2, 2018: European Journal of Surgical Oncology
Karol Polom, Christine Böger, Elizabeth Smyth, Daniele Marrelli, Hans-Michael Behrens, Luigi Marano, Thomas Becker, Florian Lordick, Christoph Röcken, Franco Roviello
BACKGROUND: Current guidelines recommend that metastatic gastric cancer should not be treated with surgery unless this is required for symptom control. We hypothesized that patients with mismatch repair deficiency (MMRd) gastric cancer and metastatic disease detected at the timepoint of surgical resection would have superior survival compared to patients with MMRd cancers in the same setting. METHODS: Clinicopathological details and survival data were collected from prospective databases at two large European centers on patients who had undergone surgery and were diagnosed with synchronous stage IV gastric cancer (distant lymph nodes, positive peritoneal cytology, peritoneal, and distant metastases) at the timepoint of surgery...
March 2, 2018: European Journal of Surgical Oncology
Aurélien Dupré, Hassan Z Malik
Chronic inflammation is an aberrantly prolonged form of a protective response to a loss of tissue homeostasis and it is involved in several steps of the carcinogenesis process. As a result, many cancers are inflammation-related. The systemic inflammatory response is associated with survival in advanced and localized cancers. Two categories of scores have been proposed to monitor the systemic inflammatory response, those derived from protein measurement and those based on counting inflammatory cells. This review aims to provide a critical appraisal of these 2 categories of surrogate markers...
March 2, 2018: European Journal of Surgical Oncology
R Kim
No abstract text is available yet for this article.
March 2, 2018: European Journal of Surgical Oncology
S Mathoulin-Pélissier, K Pritchard-Jones
Rare cancers are not so rare, their incidence is increasing and, as a group, they have worse survival than the common cancers. These factors emphasise the societal need to ensure sufficient focus on research into their biological basis, aetiological factors, new more effective therapies and organisation of healthcare to improve access to best practice and innovation. Accuracy of diagnosis is one of the first hurdles to be overcome, with around one third of tumours being reclassified - by type or risk group - when subject to a centralised pathology review process...
March 2, 2018: European Journal of Surgical Oncology
Gaëtan-Romain Joliat, Nicolas Demartines, Markus Schäfer
No abstract text is available yet for this article.
March 2, 2018: European Journal of Surgical Oncology
Michel W Wouters
No abstract text is available yet for this article.
March 2, 2018: European Journal of Surgical Oncology
Nobuhiko Taniai, Tadashi Machida, Hiroshi Yoshida, Masato Yoshioka, Youichi Kawano, Tetsuya Shimizu, Yuto Aoki
BACKGROUND: The vein that runs between ventral and dorsal Segment 8 is called the anterior fissure vein (AFV). AFV is sometimes needed as a boundary for Subsegmentectomy in Segment 8. The aim of the present study was to investigate the AFV to determine whether the AFV can be used a landmark for subsegmentectomy of the liver at Segment 8. METHODS: We analyzed data from 151 patients who had undergone abdominal computed tomographic (CT) examinations. The position of the AFV is identified by determining whether the AFV drains flows into the proximal, medial, or distal portion of the middle hepatic vein (MHV) or right hepatic vein (RHV)...
March 2, 2018: European Journal of Surgical Oncology
Maciej Nowacki, Mohammad Alyami, Laurent Villeneuve, Frederic Mercier, Martin Hubner, Wouter Willaert, Wim Ceelen, Marc Reymond, Denis Pezet, Catherine Arvieux, Vladimir Khomyakov, Laura Lay, Sergio Gianni, Wojciech Zegarski, Naoual Bakrin, Olivier Glehen
BACKGROUND: Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is a new drug delivery method offered in selected patients suffering from non-resectable peritoneal carcinomatosis (PC). As reported experience is still limited, we conducted a survey among active PIPAC centers aiming to report their technical approach and clinical findings. METHODS: An online survey was sent to active PIPAC centers worldwide. The questionnaire consisted of 34 closed questions and was conducted over a period of 3 months beginning in March 2017...
February 22, 2018: European Journal of Surgical Oncology
P H Cashin, H Mahteme, I Syk, J E Frödin, B Glimelius, W Graf
BACKGROUND: The aim was to compare health-related quality-of-life (HRQOL) and cost-effectiveness between cytoreductive surgery with intraperitoneal chemotherapy (CRS + IPC) and systemic chemotherapy for patients with colorectal peritoneal metastases. METHODS: Patients included in the Swedish Peritoneal Trial comparing CRS + IPC and systemic chemotherapy completed the EORTC QLQ-C30 and SF-36 questionnaires at baseline, 2, 4, 6, 12, 18, and 24 months. HRQOL at 24 months was the primary endpoint...
February 21, 2018: European Journal of Surgical Oncology
Fernando A Angarita, Sergio A Acuna, David R McCready, Jaime Escallon
INTRODUCTION: It is unknown whether the treatment disparity observed between young and elderly women extends to the management of positive margins after initial lumpectomy. The primary aim was to evaluate the management of positive margins after initial lumpectomy in elderly women. METHODS: Women ≥50 y who underwent lumpectomy for stage I-III tumors were identified. Tumor and treatment characteristics were collected across two subgroups: young (50-69 y) and elderly (≥70 y)...
February 21, 2018: European Journal of Surgical Oncology
Federica Bruno, Dario Baratti, Antonia Martinetti, Daniele Morelli, Elisa Sottotetti, Chiara Bonini, Marcello Guaglio, Shigeki Kusamura, Marcello Deraco
BACKGROUND: The differential diagnosis between diffuse malignant peritoneal mesothelioma (DMPM) and other peritoneal surface malignancies (PSM) is still challenging. Serum mesothelin and osteopontin are increasingly used as markers of pleural mesothelioma, but their role in DMPM is unclear. We assessed the diagnostic and prognostic values of mesothelin, osteopontin, CEA, CA19.9, CA125, and CA15.3 in DMPM patients. METHODS: Markers were dosed before cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) by enzyme-linked immunosorbent assay (ELISA) in 30 DMPM patients and 14 controls with other PSMs...
February 17, 2018: European Journal of Surgical Oncology
Zhaohui Jin, Mindy L Hartgers, Cristobal T Sanhueza, Christopher R Shubert, Steven R Alberts, Mark J Truty, Prasuna Muppa, David M Nagorney, Thomas C Smyrk, Mohamed Hassan, Amit Mahipal
INTRODUCTION: Ampullary adenocarcinoma is a rare entity with limited data on prognostic factors. The aim of this study is to identify prognostic factors and assess the benefit of adjuvant therapy in patients with ampullary adenocarcinoma who underwent pancreatoduodenectomy. METHODS: A cohort of 121 consecutive patients underwent pancreatoduodenectomy for ampullary adenocarcinoma from 2006 to 2016 at Mayo Clinic in Rochester, MN. All patients were confirmed by independent pathologic review to have ampullary carcinoma...
February 16, 2018: European Journal of Surgical Oncology
William Allum
No abstract text is available yet for this article.
February 16, 2018: European Journal of Surgical Oncology
Nicola Nicolai, Davide Biasoni, Mario A Catanzaro, Maurizio Colecchia, Annalisa Trama
Germ-cell tumours (GCT) of the testis and penile squamous cell carcinoma (PeSCC) are a rare and a very rare uro-genital cancers, respectively. Both tumours are well defined entities in terms of management, where specific recommendations - in the form of continuously up-to-dated guide lines-are provided. Impact of these tumour is relevant. Testicular GCT affects young, healthy men at the beginning of their adult life. PeSCC affects older men, but a proportion of these patients are young and the personal consequences of the disease may be devastating...
February 14, 2018: European Journal of Surgical Oncology
Ester Orlandi, Salvatore Alfieri, Christian Simon, Annalisa Trama, Lisa Licitra
Head and neck cancer (HNC) is a rare disease that can affect different sites and is characterized by variable incidence and 5-year survival rates across Europe. Multiple factors need to be considered when choosing the most appropriate treatment for HNC patients, such as age, comorbidities, social issues, and especially whether to prefer surgery or radiation-based protocols. Given the complexity of this scenario, the creation of a highly specialized multidisciplinary team is recommended to guarantee the best oncological outcome and prevent or adequately treat any adverse effect...
February 14, 2018: European Journal of Surgical Oncology
Ryoichi Miyamoto, Satoshi Inagawa, Naoki Sano, Sosuke Tadano, Shinya Adachi, Masayoshi Yamamoto
BACKGROUND: The preoperative neutrophil-to-lymphocyte ratio (NLR) is a well-known prognostic marker for gastric cancer patients. However, the utility of the NLR in predicting short-term outcomes in gastric cancer patients remains unclear. Here, we investigated whether the preoperative NLR is a predictor of short-term outcomes in gastric cancer patients. METHODS: We retrospectively evaluated 154 consecutive gastric cancer patients. We compared the perioperative outcomes and median survival times (MSTs)...
February 13, 2018: European Journal of Surgical Oncology
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