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European Journal of Surgical Oncology

Lihua Liu, Seung-Nam Jung, Chan Oh, Kyungmin Lee, Ho-Ryun Won, Jae Won Chang, Jin Man Kim, Bon Seok Koo
OBJECTIVES: Laminin subunit beta-3 (LAMB3) is a major component of the basement membrane zone. In our study, we investigated the role of LAMB3 in head and neck squamous cell carcinoma (HNSCC) progression and its clinical implication as a prognostic biomarker. MATERIALS AND METHODS: A retrospective analysis of 100 patients with HNSCC who had undergone curative surgery from 1999 to 2011 was performed. We evaluated LAMB3 expression by immunohistochemistry and its associations with clinicopathological characteristics and survival...
November 2, 2018: European Journal of Surgical Oncology
Arvind Oemrawsingh, Nadine L de Boer, Alexandra R M Brandt-Kerkhof, Cornelis Verhoef, Jacobus W A Burger, Eva V E Madsen
INTRODUCTION: Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) is a well-established curative treatment for patients with peritoneal carcinomatosis (PC) from colorectal cancer (CRC) and pseudomyxoma peritonei (PMP). The study's aim was to present a single center's initial experience with CRS and HIPEC and report the postoperative morbidity in elderly patients. METHODS: A retrospective observational study was conducted of all patients with peritoneally disseminated colorectal cancer or pseudomyxoma peritonei undergoing CRS and HIPEC between March 2014 and March 2017...
November 2, 2018: European Journal of Surgical Oncology
L R van der Werf, E Wassenaar, A de Niet, F Lalezari, H J Braam, B van Ramshorst, J Nederend, I H J T de Hingh, N F M Kok, A G J Aalbers
OBJECTIVES: To investigate the impact of retroperitoneal lymphadenopathy (RPLP) on pre-operative CT scan on overall survival (OS) and disease-free survival (DFS) after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) for peritoneal metastases (PM) of colorectal cancer. BACKGROUND: In patients with PM enlarged retroperitoneal lymph nodes (RPLP) are usually considered extra-regional lymph node metastases and therefore these patients may be excluded from CRS-HIPEC...
November 1, 2018: European Journal of Surgical Oncology
M Roman, S Labbouz, V Valtzoglou, A Ciesla, M Hawari, E Addae-Boateng, J A Thorpe, J P Duffy, A Majewski
BACKGROUND: Segmentectomy has emerged as a lung parenchymal sparring alternative to the gold standard lobectomy in non-small cell lung cancer (NSCLC) patients. We hypothesized that there is parity between functional, local recurrence and survival outcomes. PATIENTS AND METHODS: Parenchymal sparring procedures including anatomical segmentectomies were propensity score matched 1:1 with lobectomies (n = 64). The primary outcomes included survival, functional and oncological outcomes...
November 1, 2018: European Journal of Surgical Oncology
Shu-Yein Ho, Chia-Yang Hsu, Po-Hong Liu, Cheng-Yuan Hsia, Chien-Wei Su, Yi-Hsiang Huang, Ming-Chih Hou, Teh-Ia Huo
BACKGROUND: Tumor recurrence after curative resection is common in hepatocellular carcinoma (HCC), but large-scale long-term prediction on an individual basis has seldom been reported. We aimed to construct an albumin-bilirubin (ALBI) grade-based nomogram to predict tumor recurrence in patients with HCC undergoing surgical resection. METHODS: A total 1038 patients with newly diagnosed HCC undergoing curative resection between 2002 and 2016 were enrolled. Baseline characteristics, tumor status and severity of liver functional reserve were collected...
November 1, 2018: European Journal of Surgical Oncology
Wim Ceelen
In patients with colorectal peritoneal metastases (PM), the use of cytoreductive surgery (CRS) and HIPEC with oxaliplatin (OX) is increasingly used. The results of the recently reported randomized Prodige 7 trial failed to show a difference in overall survival between patients undergoing CRS alone versus CRS combined with HIPEC using high dose OX. The trial was not designed or powered, however, to detect a potentially clinically meaningful benefit in locoregional disease control. Here, I address some potential explanations for the lack of benefit in the Prodige 7 trial, including OX efficacy issues, adverse effects of intraperitoneal high dose glucose, and potential drawbacks of the use of hyperthermia...
October 31, 2018: European Journal of Surgical Oncology
Shi-Rong Zhang, Hao Li, Wen-Quan Wang, Wei Jin, Jin-Zhi Xu, Hua-Xiang Xu, Chun-Tao Wu, He-Li Gao, Shuo Li, Tian-Jiao Li, Wu-Hu Zhang, Shuai-Shuai Xu, Quan-Xing Ni, Xian-Jun Yu, Liang Liu
INTRODUCTION: Arpin (Arp2/3 complex inhibitor), a novel protein found in 2013, plays a pivotal role in cell motility and migration. However, the prognostic value of Arpin in pancreatic ductal adenocarcinoma (PDAC) remains unknown. MATERIALS AND METHODS: We analyzed the gene expression of ARPIN using the GEO dataset (GSE71989) and validated the results by immunohistochemistry (IHC) and Western blot in our clinical database. Tissue microarray specimens from 214 patients who underwent curative pancreatectomy for PDAC were used...
October 30, 2018: European Journal of Surgical Oncology
Durval R Wohnrath, Raphael L C Araujo
BACKGROUND: The extension of lymphadenectomy for GA remains on debate even after Eastern and Western clinical trials. The main concern is if morbidity of extended lymphadenectomy could be justified based on benefits in oncologic outcomes. This study addressed the extension of lymphadenectomy as a prognostic factor of overall survival (OS) for gastric adenocarcinoma (GA). METHODS: Consecutive patients who underwent gastrectomy for GA were retrospectively evaluated...
October 30, 2018: European Journal of Surgical Oncology
Rongrong Chen, Xiaohua Yang, Zhengping Ding, Lei Zhu, Shun Lu, Yongfeng Yu
BACKGROUND: There is currently no definite clinical implication for the subtypes of lung squamous cell carcinoma according to the 2015 WHO classification. This study aimed to investigate postoperative recurrence of the two major subtypes of lung squamous cell carcinoma: keratinizing squamous cell carcinoma (KSCC) and nonkeratinizing squamous cell carcinoma (NKSCC). METHODS: We identified the patients with KSCC and NKSCC who had undergone complete resection in Shanghai Chest Hospital between April 2015 and June 2016...
October 28, 2018: European Journal of Surgical Oncology
Xiaofeng Chen, Qinyun Ma, Shaohua Wang, Huijun Zhang, Dayu Huang
BACKGROUND: Thoracic dumbbell tumors are uncommon neoplasms arising from neurogenic elements of the posterior mediastinum. Surgical removal of these tumors with mediastinal, neuroforaminal and intraspinal components can often be challenging. The purpose of this study is to present our experience of single-stage removal of dumbbell tumors of the posterior mediastinum and to discuss the surgical strategies for such tumors. METHOD: A retrospective analysis was performed on 20 patients who underwent surgery for thoracic dumbbell tumors at our department during the period 2008 to 2016...
October 28, 2018: European Journal of Surgical Oncology
Oh Jeong, Mi Ran Jung, Seong Yeob Ryu
BACKGROUND: Lymph nodes (LNs) at the splenic hilum (no. 10) are treated as regional LNs in proximal gastric carcinoma. However, patients with no.10 LN metastasis show a poor prognosis after curative surgery. This study aimed to investigate the prognostic impact of no.10 LN metastasis in proximal gastric carcinoma. METHODS: We retrospective reviewed 665 proximal gastric carcinoma patients who underwent total gastrectomy and D2 LN dissection. Clinicopathological features were compared between patients with and without no...
October 26, 2018: European Journal of Surgical Oncology
Tianwen Yuan, Yueqi Zhu, Xing Wang, Wenguo Cui, Jun Cao
Paclitaxel-eluting covered metal stents (PECMSs) and metallic stents covered with a paclitaxel-incorporated membrane (MSCPMs) have been developed to increase stent patency by preventing tumor ingrowth. However, few studies have compared their efficacy and safety compared with conventional covered metal stents (CMSs). This study aimed to compare differences in efficacy and safety between PECMS/MSCPM and CMS by meta-analysis. A search of PubMed and Embase was conducted for randomized controlled trials of PECMS/MSCPM and CMS in patients with malignant biliary obstructions published between January 1966 and August 2017...
October 25, 2018: European Journal of Surgical Oncology
Danique M S Berger, Roos M Wassenberg, Katarzyna Jóźwiak, Bart A van de Wiel, Alfons J M Balm, José G van den Berg, W Martin C Klop
BACKGROUND: TNM staging of melanoma has recently been altered by the introduction of the 8th edition of the AJCC Cancer Staging manual. The purpose of this study is to analyze the inter-observer variation of histopathology reports and its effect on recommended treatment policy. METHODS: We retrospectively analyzed 296 cases, diagnosed as primary cutaneous head and neck melanoma (2005-2016), referred to the Netherlands Cancer Institute (NCI) for treatment after prior diagnosis in another hospital (non-NCI)...
October 25, 2018: European Journal of Surgical Oncology
Fumi Harada, Ryusei Matsuyama, Ryutaro Mori, Takafumi Kumamoto, Daisuke Morioka, Masataka Taguri, Shoji Yamanaka, Itaru Endo
INTRODUCTION: The World Health Organization (WHO) proposed an integrated classification for intraductal papillary neoplasm of the bile duct (IPNB) in 2010. However, IPNB reportedly shows considerable geographic variation. This Japanese single-institution study examined outcomes of surgery for IPNB and the prognostic impact of immunohistochemical mucin expression patterns. MATERIALS AND METHODS: Patients with IPNB were identified from 413 patients who underwent curative-intent surgery for biliary tract (excluding gallbladder) neoplasms from 1992 to 2016 by retrospective macro- and microscopic reevaluation of resected specimens...
October 24, 2018: European Journal of Surgical Oncology
Abdi-Fatah Hersi, Staffan Eriksson, Joakim Ramos, Shahin Abdsaleh, Fredrik Wärnberg, Andreas Karakatsanis
BACKGROUND: Surgery for non-palpable breast cancer may often be a challenging procedure. Recently, a magnetic seed (Magseed® ) used for tumour localization has been developed. Superparamagnetic iron oxide nanoparticles (SPIO) for sentinel lymph node (SN) detection is a novel tracer that may be injected up to four weeks preoperatively. This study is the first combining the magnetic seed and SPIO. MATERIAL AND METHODS: Patients planned for breast conserving surgery and SN-biopsy (SNB) were recruited from two units in Sweden...
October 23, 2018: European Journal of Surgical Oncology
Zhi-Bo Xie, Lie Yao, Chen Jin, Yi-Fan Zhang, De-Liang Fu
BACKGROUND: Hyaluronan-binding protein 1 (HABP1) overexpression has been confirmed in different malignancies and found to be strongly associated with tumor development and progression. The aim of the present study was to explore the impact of HABP1 in pancreatic ductal adenocarcinoma (PDAC) patients. METHOD: HABP1 expression was evaluated in 89 PDAC specimens. RESULTS: The expression of HABP1 was significantly higher in tumor tissues than that in adjacent normal tissues...
October 21, 2018: European Journal of Surgical Oncology
Salvatore Siracusano, Carolina D'Elia, Maria Angela Cerruto, Mauro Gacci, Stefano Ciciliato, Alchiede Simonato, Antonio Porcaro, Vincenzo De Marco, Renato Talamini, Laura Toffoli, Omar Saleh, Sergio Serni, Francesco Visalli, Mauro Niero, Cristina Lonardi, Ciro Imbimbo, Paolo Verze, Vincenzo Mirone, Marco Racioppi, Massimo Iafrate, Giovanni Cacciamani, Davide De Marchi, Pierfrancesco Bassi, Walter Artibani
INTRODUCTION: Women undergoing radical cystectomy (RC) followed by urinary diversion (UD) for bladder cancer experience a substantial reduction in health-related quality of life (HRQOL). At present, studies comparing long-term QOL outcomes for different UD methods, needed to inform evidence-based choices of bladder reconstruction for female patients, are sparse. Our objective was to compare two common UD methods in terms of their HRQOL outcomes in women. MATERIALS AND METHODS: We retrospectively analysed HRQOL in 73 consecutive female bladder cancer patients having undergone orthotopic ileal neobladder (IONB, N = 24) or ileal conduit (IC, N = 49) following RC between 2007 and 2013 in six Italian academic urological centres...
October 21, 2018: European Journal of Surgical Oncology
Hao Chen, Zhaoqing Tang, Ling Chen, Haojie Li, Xuefei Wang, Fenglin Liu, Yihong Sun
BACKGROUND: The aim of this study was to investigate the prognostic value of tumor deposits (TDs) in patients with gastric cancer after radical gastrectomy. METHODS: We retrospectively reviewed 1518 patients who had undergone radical gastrectomy in Zhongshan Hospital between 2003 and 2011. Correlations between TDs and other clinicopathological characteristics were analyzed. Univariate and multivariate analysis of prognostic factors were conducted. The predictive ability of different staging systems incorporating TDs were evaluated...
October 20, 2018: European Journal of Surgical Oncology
Valerio Belgrano, Dimitrios Katsarelias, Jan Mattsson, Roger Olofsson Bagge
INTRODUCTION: Sentinel node biopsy (SNB) for melanoma gives prognostic information, however the success is dependent on several factors. The aim of this study was to describe outcome data after the introduction of the technique at our centre, including analysis of false negative rate (FNR), predictive factors for positive sentinel node (SN) and non-sentinel node (NSN), as well as prognostic factors for melanoma-specific survival (MSS). MATERIALS AND METHODS: This is a retrospective observational study of a prospectively kept database at Sahlgrenska University Hospital...
October 19, 2018: European Journal of Surgical Oncology
Zeyu Luo, Lin Zhou, Alpha I Balde, Zhou Li, Linyun He, Cai ZhenWei, ZeNan Zou, ShengYi Huang, Shuai Han, Min Wei Zhou, Gang Qing Zhang, Zhai Cai
BACKGROUND: Advanced gastric cancer (AGC) causes debilitating malnutrition and leads to deterioration of the immune response. However, the concept of the prognostic nutritional index (PNI) is controversial when applied to patients with AGC. The aim of the present study was to evaluate the effect of the PNI after gastrectomy in patients with AGC. MATERIALS AND METHODS: A multicenter retrospective study was conducted using propensity score matching (PSM) in gastric adenocarcinoma patients who underwent resection via laparoscopic or open surgery between 2014 and 2017...
October 19, 2018: European Journal of Surgical Oncology
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