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Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery

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https://www.readbyqxmd.com/read/30417211/nimotuzumab-containing-regimen-for-pediatric-diffuse-intrinsic-pontine-gliomas-a-retrospective-multicenter-study-and-review-of-the-literature
#1
Rejin Kebudi, Fatma Betul Cakir, Sema Buyukkapu Bay, Omer Gorgun, Pelin Altınok, Ayça Iribas, Fulya Yaman Agaoglu, Emin Darendeliler
PURPOSE: Nimotuzumab is an IgG1 antibody that targets epidermal growth factor receptor (EGFR). Overexpression of EGFR is detected in some pediatric brain tumors including diffuse intrinsic pontine gliomas (DIPG)s. METHODS: Since May 2010, nimotuzumab, combined with carboplatin or vinorelbine or Temozolomide (TMZ), was administered during progressive disease (PD) after the use of the institutional protocol consisting of radiotherapy (RT) + TMZ and adjuvant TMZ...
November 11, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/30417210/early-intraventricular-baclofen-therapy-ivb-for-children-with-dystonic-and-dysautonomic-storm
#2
Claudio Ruggiero, Giulia Meccariello, Pietro Spennato, Giuseppe Mirone, Stefania Graziano, Marco Gilone, Giuseppe Cinalli
INTRODUCTION: Intrathecal baclofen (ITB) is an effective treatment for managing primary and secondary dystonia. Intraventricular baclofen (IVB) was first developed to allow treating patients in which the use of ITB was difficult due to anatomic anomalies. After that, several studies indicate that intraventricular administration of baclofen, is more effective than ITB in refractory dystonia. CLINICAL MATERIAL: We report three cases of children with acute dystonic and dysautonomic storm, treated with IVB...
November 11, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/30415313/the-quality-of-life-in-extracorporeal-life-support-survivors-single-center-experience-of-a-long-term-follow-up
#3
Valentina Di Leo, Paolo Biban, Federico Mercolini, Francesco Martinolli, Andrea Pettenazzo, G Perilongo, Angela Amigoni
OBJECTIVE: To evaluate the health-related quality of life on a very long-term follow-up in patients treated with extracorporeal membrane oxygenation (ECMO) during neonatal and pediatric age. DESIGN: Prospective follow-up study. SETTING: Pediatric Intensive Care Unit of a tertiary-care University-Hospital. PATIENTS: Out of 20 neonates and 21 children treated with ECMO in our center, 24 patients underwent short-term neurological follow-up...
November 10, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/30406421/intracranial-ewing-sarcoma-with-whole-genome-study
#4
Jeemin Yim, Woo Seung Lee, Seung Ki Kim, Hyoung Jin Kang, Jeongmo Bae, Sung-Hye Park
INTRODUCTION: Ewing sarcoma (ES) as a primary intracranial tumor is very rare. Recently, CNS embryonal tumors with ES-like genomic change have been reported. Patients and methods We report a case of intracranial Ewing sarcoma in a 13-year-old girl who complained of headache and migraine. The tumor had developed in the right middle cranial fossa with a mass effect on the brain with impending transuncal herniation. RESULTS: Undifferentiated small round cell morphology with completely negative results for friend leukemia integration 1 transcription factor (Fli-1) and a nonspecific cytoplasmic CD99-positive staining pattern mislead the diagnosis as central nervous system (CNS) embryonal tumor, NOS...
November 7, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/30377774/infant-toddler-motor-skills-as-predictors-of-cognition-and-language-in-children-with-and-without-positional-skull-deformation
#5
Brent R Collett, Erin R Wallace, Deborah Kartin, Matthew L Speltz
PURPOSE: To estimate associations between early motor abilities (at two age points, 7 and 18 months on average) and cognitive/language outcomes at age 3. To determine whether these associations are similar for children with and without positional plagiocephaly and/or brachycephaly (PPB). METHODS: The Bayley Scales of Infant/Toddler Development 3 were given at all age points to 235 children with PPB and 167 without PPB. Linear regressions assessed longitudinal associations between fine and gross motor scales and cognition/language...
October 30, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/30361762/pediatric-glossopharyngeal-neuralgia-a-comprehensive-review
#6
Rafik Shereen, Brady Gardner, Juan Altafulla, Emily Simonds, Joe Iwanaga, Zachary Litvack, Marios Loukas, R Shane Tubbs
INTRODUCTION: Debilitating facial pain can seriously affect an individual's daily living. Given that the pathophysiology behind neuropathic and myofascial pain is not fully understood, when chronic facial pain goes undiagnosed, it has been proposed that one of the two is the likely cause. Since their discovery, glossopharyngeal neuralgia (GN) and Eagle's syndrome have been considered mostly conditions afflicting the adult population. However, when pediatric patients present with symptoms resembling GN or Eagle's syndrome, physicians are less apt to include these as a differential diagnosis simply due to the low prevalence and incidence in the pediatric population...
October 25, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/30361761/early-diagnosis-of-grisel-s-syndrome-in-children-with-favorable-outcome
#7
Hakan Ozalp, Vural Hamzaoglu, Emel Avci, Derya Karatas, Onur Ismi, Derya Umit Talas, Celal Bagdatoglu, Ahmet Dagtekin
PURPOSE: The painful torticollis only itself may be a major sign for the diagnosis of Grisel's syndrome (GS). It is known as an inflammatory atlantoaxial rotatory subluxation following upper respiratory tract infections (URTI) and surgical otolaryngological procedures. PATIENTS AND METHODS: The analysis of 16 pediatric GS patients were reviewed retrospectively by considering the diagnosis, the treatment modality, and the prognosis at the Department of Neurosurgery and Otorhinolaryngology in Mersin University, Faculty of Medicine between 2008 and 2018...
October 25, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/30353305/primary-intracranial-extraosseous-ewing-s-sarcoma
#8
Amir Humza Sohail, Mohammed Sachal, Muhammad Arslan Arif Maan, Muhammad Soban, Muhammad Salman Khan, Muhammad Ehsan Bari
INTRODUCTION: Common sites of occurrence of extraosseous Ewing's sarcoma include the soft tissues and bones of the lower extremity, 12 paravertebral, and retroperitoneal regions. Primary intracranial Ewing's sarcoma/pPNET is usually intraparenchymal located 13 when supratentorially, and an extraaxial epidural tumor radiographically mimicking a meningioma is extremely rare. CASE PRESENTATION: A 20-year14 old male presented to the emergency department with a 1-day history of drowsiness, headache, and fever...
October 23, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/30349985/dizygotic-opposite-sex-twins-with-surgically-repaired-concordant-myelomeningocele-conceived-by-in-vitro-fertilization-using-intracytoplasmic-sperm-injection-a-case-report-and-review-of-the-literature
#9
Sarah Stricker, Cécile Balmer, Raphael Guzman, Jehuda Soleman
BACKGROUND: Myelomeningocele (MMC) is a common subtype of congenital neural tube defects (NTD). Although congenital malformations including NTD are more common in twins, concordance, especially in dizygotic twins, is extremely rare and is found mostly in same-sex twins. The role of genetic and environmental factors in the etiology of MMC is unclear. CASE REPORT: Dizygotic twins of opposite sex were born at term to a 35-year-old woman conceived with in vitro fertilization (IVF) using intracytoplasmic sperm injection (ICSI)...
October 22, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/30341660/surgical-considerations-in-a-paediatric-case-of-a-large-skull-base-epithelioid-haemangioendothelioma
#10
Suyi Ooi, Matthew Gutman, Chris Xenos, Ronil Chandra, Catriona McLean
Intracranial epithelioid haemangioendothelioma (EHE) is a rare intermediate grade vascular tumour with heterogeneous clinical and histopathological behaviour. We present the surgical considerations of an exceptionally large skull-based EHE in an 11-year old female who presented to our institution with headaches and a protuberance over the left parietal area. Magnetic resonance imaging (MRI) demonstrated a left sided 10.5 × 6.6 × 11.1 cm extra-axial tumour arising from the parieto-temporaloccipital region which was continuous with the calvarium...
October 19, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/30338361/endoscopic-transnasal-resection-of-optic-pathway-pilocytic-astrocytoma
#11
Sarah Bin Abdulqader, Ziyad Al-Ajlan, Abdulrahman Albakr, Wisam Issawi, Mohammed Al-Bar, Pablo F Recinos, Saad Alsaleh, Abdulrazag Ajlan
PURPOSE: Optic pathway gliomas (OPGs) are low-grade neoplasms that primarily affect children. The management of OPGs remains controversial. Reports on the use of the endoscopic endonasal approach (EEA) in OPGs are extremely limited, and no such reports exist on its utility for pediatric OPGs. Here, we report our results and experience with OPGs treated with the EEA. METHODS: We retrospectively reviewed the medical records of OPG patients who were treated surgically via the EEA at our institutions from 2015 to 2017...
October 18, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/30338360/ventral-and-dorsal-tethering-bands-of-the-spinal-cord-in-the-same-patient-a-case-report
#12
Seif Eid, Joe Iwanaga, Marios Loukas, W Jerry Oakes, R Shane Tubbs
Fibrous bands are one of the causes of tethered cord syndrome and these can be located on the dorsal or more rarely, ventral aspect of the dura mater. We report a case of dorsal and ventral tethering bands in the same patient found at surgery for tethered cord syndrome. Such fibrous bands restrict normal movement of the spinal cord and lead to a variety of neurological symptoms. To our knowledge, we report the first case of dorsal and ventral tethering bands of the spinal cord in the same patient. This case report aims to increase awareness of such anatomical variations and emphasize the importance of meticulous surgical dissection in order to identify such bands...
October 18, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/30338359/-it-is-not-what-it-seems-ultrasound-findings-in-a-case-of-unusual-iatrogenic-ulnar-nerve-damage
#13
LETTER
Daniele Coraci, Silvia Giovannini, Luca Gentile, Julianne Tannous Cordenonssi, Luca Padua
No abstract text is available yet for this article.
October 18, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/30283986/posterior-circulation-involvement-and-collateral-flow-pattern-in-moyamoya-disease-with-the-rnf213-polymorphism
#14
Won-Hyung Kim, Sang-Dae Kim, Myung-Hyun Nam, Jin-Man Jung, Sung-Won Jin, Sung-Kon Ha, Dong-Jun Lim, Hae-Bin Lee
PURPOSE: Moyamoya disease is a chronic cerebrovascular disorder characterized by progressive stenosis of the circle of Willis with a compensatory collateral vessel network. Recent studies have identified the ring finger protein 213 gene (RNF213) as the unique susceptibility gene for moyamoya disease. The purpose of this study was to compare clinical features of moyamoya disease, especially angiographic findings, between patients with and without the RNF213 mutation. METHODS: Blood samples from 35 patients with moyamoya disease were obtained between May 2016 and May 2017...
October 3, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/30280214/expression-profiles-of-pro-inflammatory-and-pro-apoptotic-mediators-in-secondary-tethered-cord-syndrome-after-myelomeningocele-repair-surgery
#15
Gesa Cohrs, Bea Drucks, Jan-Philip Sürie, Christian Vokuhl, Michael Synowitz, Janka Held-Feindt, Friederike Knerlich-Lukoschus
PURPOSE: The literature on histopathological and molecular changes that might underlie secondary tethered cord syndrome (TCS) after myelomeningocele (MMC) repair surgeries remains sparse. To address this problem, we analyzed specimens, which were obtained during untethering surgeries of patients who had a history of MMC repair surgery after birth. METHODS: Specimens of 12 patients were analyzed in this study. Clinical characteristics were obtained retrospectively including pre-operative neurological and bowel/bladder-function, contractures and spasticity of lower extremities, leg and back pain, syringomyelia, and conus position on spinal MRI...
October 3, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/30276652/conservative-and-operative-management-of-iatrogenic-craniocerebral-disproportion-a-case-based-review
#16
Thomas Beez, Christopher Munoz-Bendix, Sebastian Alexander Ahmadi, Martina Messing-Jünger, Hans-Jakob Steiger, Andreas Röhrig
INTRODUCTION: Craniocerebral disproportion (CCD) can occur as a sequela after shunting in early infancy. It can be understood as a disorder closely related to slit ventricle syndrome and chronic overdrainage syndrome. Here, we present two exemplary cases and summarize the pathophysiological, diagnostic, and therapeutic approaches to CCD. CLINICAL PRESENTATION: Two premature babies underwent shunting for posthemorrhagic hydrocephalus and presented in later childhood with recurrent episodes of symptomatic raised intracranial pressure (ICP) at 2 and 8 years of age, respectively...
October 2, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/30276650/atlanto-axial-rotatory-fixation-complicating-ventriculo-peritoneal-shunt-surgery-a-case-report-and-literature-review
#17
Costanza Zattra, Marco Paolo Schiariti, Emanuele La Corte, Morgan Broggi, Francesco Acerbi, Paolo Ferroli
INTRODUCTION: Atlanto-axial rotatory fixation (AARF) is a rare complication of ventriculo-peritoneal shunt (VPS) surgery. CASE PRESENTATION: The authors present a unique case of AARF developing early after VP shunting, with persistent torticollis, a "cock-robin" head position, and a thick fibrous band along the catheter path. Due to refractoriness to conservative treatments, AARF, which can be an early-onset complication of VPS surgery, was resolved by removing the distal catheter along with the fibrous band encasing it...
October 1, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/30259086/giant-cell-tumor-of-the-eleventh-thoracic-vertebra-in-a-pediatric-patient-an-interesting-case-report-and-comprehensive-literature-review
#18
Kadir Oktay, Ebru Guzel, Serkan Simsek, Aslan Guzel
INTRODUCTION: Giant cell tumors of the mobile spinal column are very rare tumors, especially in the pediatric age group. Although they are benign tumors, they have locally aggressive growth pattern and high risk of recurrence. CASE PRESENTATION: We report a 15-year-old female patient with thoracic giant cell tumor who underwent percutaneous vertebroplasty and had cement extravasation into the spinal canal. Because of the deterioration of the patient's neurological condition, total enbloc spondylectomy and cement excision were performed...
September 26, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/30250987/factors-affecting-diagnosis-of-primary-pediatric-central-nervous-system-neoplasias-in-a-developing-country
#19
Isadora Olenscki Gilli, Andrei Fernandes Joaquim, Helder Tedeschi, Simone Dos Santos Aguiar, Andre Moreno Morcillo, Enrico Ghizoni
PURPOSE: Understand the variables that could interfere with diagnosis and prompt treatment in CNS childhood cancer in Brazil, a developing country with continental dimensions. METHODS: From 2005 to 2010, we retrospectively evaluated factors, which could represent a negative influence on the time period elapsing from the onset of symptoms until the diagnosis of the central nervous system (CNS) neoplasia in children and adolescents attended in our service. RESULTS: Two hundred seventeen records were analyzed retrospectively...
September 24, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/30218142/physiologic-closure-time-of-the-metopic-suture-in-south-australian-infants-from-3d-ct-scans
#20
Sophie Jane Teager, Sarah Constantine, Nicolene Lottering, Peter John Anderson
Metopic synostosis is a craniofacial condition characterised by the premature fusion of the metopic suture. This early fusion restricts frontal bone growth [17] and has significant impacts on the developing infant during a critical phase of rapid growth and development [4]. Diagnosis of the condition is usually achieved by clinical assessment, followed by a three-dimensional computed tomography (3D CT) scan, verifying premature metopic suture fusion. PURPOSE: This retrospective study aims to investigate the timing of metopic suture fusion in the developing infant in an Australian subpopulation...
September 14, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
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