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Folia Histochemica et Cytobiologica

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https://www.readbyqxmd.com/read/30294774/semispecific-tppii-inhibitor-ala-ala-phe-chloromethylketone-aaf-cmk-displays-cytotoxic-activity-by-induction-of-apoptosis-autophagy-and-protein-aggregation-in-u937-cells
#1
Lukasz P Bialy, Jean Fayet, Grzegorz M Wilczyński, Izabela Mlynarczuk-Bialy
INTRODUCTION: The main component of extralysosomal proteolysis is the ubiquitin-proteasome system (UPS), which is supplemented by tripeptidyl peptidase II (TPPII). That system is a target for anticancer strategies by using proteasome inhibitors. Data from several studies on leukemic cells share evidence for the beneficial and potential role of TPPII in cell survivability. Therefore, the aim of this work was to analyze the effect of AAF-cmk, a membrane permeable semi-specific TPPII inhibitor, on human monocytic leukemic cells U937 for translational research...
October 8, 2018: Folia Histochemica et Cytobiologica
https://www.readbyqxmd.com/read/30187908/expression-of-peroxiredoxins-in-the-human-testis-epididymis-and-spermatozoa-and-their-role-in-preventing-h2o2-induced-damage-to-spermatozoa
#2
Hui Shi, Juan Liu, Peng Zhu, Haiyan Wang, Zhenjun Zhao, Guohong Sun, Jianyuan Li
INTRODUCTION: High levels of reactive oxygen species (ROS) have potential toxic effects on testicular function and sperm quality. Peroxiredoxins (PRDXs) are enzymes with a role as ROS scavenger. The aim of the study was to reveal the presence and localization of PRDXs in human testis, epididymis and spermatozoa, and the protective roles of PRDX2 and PRDX6 in sperm motility. MATERIAL AND METHODS: The presence and localization of PRDXs in the human testis, epididymis and spermatozoa were detected by immunohistochemistry, western blot and immunofluorescence...
2018: Folia Histochemica et Cytobiologica
https://www.readbyqxmd.com/read/30187907/immunohistochemical-analysis-of-spinal-cord-components-in-mouse-model-of-experimental-autoimmune-encephalomyelitis
#3
Grazyna Pyka-Fosciak, Mariusz Stasiolek, Jan A Litwin
INTRODUCTION: Experimental autoimmune encephalomyelitis (EAE) is a widely used animal model for studying immunopathology of multiple sclerosis (MS) because it repeats the hallmarks of the human disease, such as focal inflammation and demyelination of the central nervous system, subsequently leading to axonal and neuronal loss. The interrelationships, timing and sequence of different pathological processes that lead to histologically observed lesions in SM are still incompletely understood...
2018: Folia Histochemica et Cytobiologica
https://www.readbyqxmd.com/read/30187906/matrix-metalloproteinases-2-7-and-tissue-metalloproteinase-inhibitor-1-expression-in-human-endometrium
#4
Barbara Grzechocinska, Filip A Dabrowski, Anna Cyganek, Marcin Chlebus, Christopher Kobierzycki, Lukasz Michalowski, Barbara Gornicka, Miroslaw Wielgos
INTRODUCTION: Endometrium undergoes regular, cyclic tissue remodeling mostly associated to the endocrine system status. It is well-known fact that steroid hormones are strongly responsible for changes in endometrium. The precise mechanism of their action is still under investigation. The aim of the study was to evaluate the expression of metalloproteinases 2 and 7 (MMP-2, -7) and tissue inhibitor of metalloproteinase 1 (TIMP-1) in human endometrium in relation to serum concentrations of estradiol and progesterone during different phases of menstrual cycle...
2018: Folia Histochemica et Cytobiologica
https://www.readbyqxmd.com/read/30070682/study-of-the-hydromineral-regulation-of-typhlonectes-compressicauda-according-to-the-seasonal-variation
#5
Mohammad Yousef, Elara N Moudilou, Hafsa Djoudad-Kadji, Jean-Marie Exbrayat
INTRODUCTION: Typhlonectes compressicauda is a viviparous gymnophionan amphibian living in tropical areas of South America. This lengthened amphibian is submitted to seasonal variations characterized by the rainy season (from January to June) and the dry season (from July to December). The mineral homeostasis in amphibians is partly ensured by the neurohormones arginine-vasotocin (AVT), and mesotocin (MST). These two hormones were localized in the hypothalamus, and their receptors, mesotocin receptors (MTR) and vasotocin receptors (VTR2) in the kidney...
2018: Folia Histochemica et Cytobiologica
https://www.readbyqxmd.com/read/30053310/age-associated-functional-morphology-of-thyroid-and-its-impact-on-the-expression-of-vimentin-cytokeratins-and-vegf-the-role-of-nigella-in-refinement
#6
Sherif Mohamed Zaki, Enas Ahmed Mohamed, Shereen Abdel Fattah, Hend Abdullah, Lucyna Kaszubowska
INTRODUCTION: Aging causes morphological and functional changes in the thyroid gland. Free radicals play a key role in the pathology of normal aging. Vimentin and cytokeratin are cytoskeletal intermediate filaments that are often used as indirect indices of tissue injury. The aim of the study was to clarify the age-related alterations in the structure and function of the thyroid gland. The relationship between oxidative/antioxidative stress markers and cytoskeletal intermediate filaments (vimentin and cytokeratin) and oxidative/antioxidative stress markers as well as vascular endothelial growth factor (VEGF) during aging were elucidated...
2018: Folia Histochemica et Cytobiologica
https://www.readbyqxmd.com/read/29998457/effects-of-genistein-on-insulin-pathway-related-genes-in-mouse-differentiated-myoblast-c2c12-cell-line-evidence-for-two-independent-modes-of-action
#7
Slawomir Lewicki, Aneta Lewicka, Boleslaw Kalicki, Agnieszka Sobolewska-Ruta, Bogdan Debski, Robert Zdanowski, Tomasz Syryło, Malgorzata Kloc, Jacek Z Kubiak
INTRODUCTION: Genistein (plant isoflavone) is a well-known anti-cancer drug with estrogenic-like properties. Genistein also regulates sugar and lipid metabolism; thus, it has anti-diabetic properties. The aim of the study was to evaluate in vitro effects of genistein on glucose transport, fatty acids oxidation, activation of PKB, and expression of genes related to insulin pathway in differentiated myoblast C2C12 mouse cell line. MATERIAL AND METHODS: Differentiated myoblast C2C12 mouse cell line was used to assess the effects of different genistein concentrations on glucose transport and fatty acids oxidation measured by radioactivity technique, activation of PKB, and expression of selected genes related to insulin signaling pathway (IR-a, IR-b, IRS-1, PKB, GLUT-4, PP2A, SH-PTP2) at the mRNA and protein levels...
2018: Folia Histochemica et Cytobiologica
https://www.readbyqxmd.com/read/29949181/endometriosis-insights-into-a-multifaceted-entity
#8
Cornelia Amalinei, Ioana Păvăleanu, Ludmila Lozneanu, Raluca Balan, Simona-Eliza Giuşcă, Irina-Draga Căruntu
Firstly described at the end of nineteenth century, endometriosis remains an enigmatic disease, from etio-pathogenesis to specific markers of diagnosis and its ability to associate with malignancies. Our review has been designed from a historical perspective and steps up to an updated understanding of the disease, facilitated by relatively recent molecular and genetic progresses. Although the histopathological diagnosis is relatively simple, the therapy is difficult or ineffective. Experimental models have been extremely useful as they reproduce the human disease and allow the testing of different potential modulators or treatment options...
2018: Folia Histochemica et Cytobiologica
https://www.readbyqxmd.com/read/29888781/alterations-in-porcine-intrahepatic-sympathetic-nerves-after-bisphenol-a-administration
#9
Michael Thoene, Janusz Godlewski, Liliana Rytel, Ewa Dzika, Ewa Bejer-Olenska, Joanna Wojtkiewicz
INTRODUCTION: Bisphenol A (BPA) is used in the chemical industry for manufacturing plastics which are used as food packaging. Data indicate that BPA is released from such products and is widely present in the environment and the human body. So far, the EFSA and the US FDA have determined "safe" BPA oral exposure levels, and a large amount of data indicates that BPA is harmful even at low-doses. Our previously performed analyses concerning BPA exposure demonstrated the impact of this substance on parasympathetic and peptidergic nerve fibers present within the liver...
2018: Folia Histochemica et Cytobiologica
https://www.readbyqxmd.com/read/29888780/immunohistochemical-expression-of-fascin-1-in-colorectal-cancer-in-relation-to-clinical-and-pathological-parameters
#10
Barbara M Piskor, Anna Pryczynicz, Emilia Lubowicka, Katarzyna Miniewska, Justyna Zinczuk, Konrad Zareba, Katarzyna Guzinska-Ustymowicz
INTRODUCTION: Fascins are a group of proteins taking part in the maintenance of a proper structure of the cellular cytoskeleton. Fascin-1 is an actin-bundling protein present in neurons, fibroblasts, endothelial, smooth muscle, dendritic and mesenchymal cells whereas lack of its expression is characteristic of epithelial cells. Fascin-1 overexpression can be observed in neoplastic cells. Therefore, the aim of this study was to assess the expression of Fascin-1 protein in patients with colorectal cancer (CRC) and to analyze associations between Fascin-1 ex-pression and clinical-pathological parameters...
2018: Folia Histochemica et Cytobiologica
https://www.readbyqxmd.com/read/29873058/immunohistochemical-study-on-neuropilin-1-nrp1-immunoexpression-in-oral-squamous-cell-carcinoma
#11
Olga Stasikowska-Kanicka, Małgorzata Wągrowska-Danilewicz, Marian Danilewicz
INTRODUCTION: Neuropilins (NRPs) are multifunctional glycoproteins that play an important role in angiogenesis and cancer progression. The aim of the study was to examine the immunoexpression of neuropilin 1 (NRP1), the number of NRP1+ infiltrating cells and CD163+ macrophages, and density of microvessels (MVD) in oral squamous cell carcinoma (OSCC). MATERIAL AND METHODS: The study was performed on 45 OSCC patients with metastases (OSCCM+), 51 patients without metastases (OSCCM-) and 17 control cases...
2018: Folia Histochemica et Cytobiologica
https://www.readbyqxmd.com/read/29873057/the-concentration-of-ethanol-affects-its-penetration-rate-in-bovine-cardiac-and-hepatic-tissues
#12
Matthew Dunster-Jones, Michelle Steicke, James Mackie, Rachel Guthrie, Tam Nguyen Dinh, Fahima Ahmady, Jonathan Golledge, Yutang Wang
INTRODUCTION: Ethanol is a commonly used fixative. Fixation of the inner layers of the tissue depends on the ability of the fixative to diffuse into the tissue. It is unknown whether the concentration of ethanol affects its penetration into tissues. This study aimed to compare the penetration rates of 50% and 100% ethanol into bovine heart and liver tissues. MATERIALS AND METHODS: The penetration distance and tissue shrinkage or expansion were measured by analysing the digital images of the heart and liver tissues before and after immersion in ethanol at 20°C for 2, 6, 24 or 30 hours...
2018: Folia Histochemica et Cytobiologica
https://www.readbyqxmd.com/read/29770958/effects-of-massage-on-the-expression-of-proangiogenic-markers-in-rat-skin
#13
Katarzyna Ratajczak-Wielgomas, Krzysztof Kassolik, Jedrzej Grzegrzolka, Tomasz Halski, Aleksandra Piotrowska, Katarzyna Mieszala, Iwona Wilk, Marzenna Podhorska-Okolow, Piotr Dziegiel, Waldemar Andrzejewski
INTRODUCTION: Massage is a physiotherapeutic treatment, commonly used in both therapy and restoration of normal body functions. The aim of this work was to determine the effects of skin massage on stimulating the expression of angiogenesis-initiating factors, i.e. VEGF-A, FGF-2 (bFGF) and CD34 and on skin regeneration processes. MATERIAL AND METHODS: The study was conducted on 48 Buffalo strain rats, randomly divided into two groups. In the first group (M, the massaged group), massage was applied five times a week for 7 weeks...
2018: Folia Histochemica et Cytobiologica
https://www.readbyqxmd.com/read/29702723/professor-zofia-bielanska-osuchowska-1919-2017
#14
Jerzy Kawiak, Andrzej Łukaszyk
No abstract text is available yet for this article.
2018: Folia Histochemica et Cytobiologica
https://www.readbyqxmd.com/read/29577227/pathological-study-of-pulmonary-toxicity-induced-by-intratracheally-instilled-asian-sand-dust-kosa-effects-of-lowered-serum-zinc-level-on-the-toxicity
#15
Akinori Shimada, Kotaro Miyake, Yuri Kenmotsu, Kikumi Ogihara, Yuko Naya, Misaki Naota, Takehito Morita, Kenichiro Inoue, Hirohisa Takano
I: NTRODUCTION: We have previously reported that Asian sand dust (ASD) induced acute and chronic inflammatory changes in the lung of mice. Zinc (Zn) is reported to influence inflammation and wound healing. The purpose of the study was to assess the effects of lowered serum Zn levels on the lung toxicity induced by ASD. MATERIAL AND METHODS: Mice that were fed diets containing normal (group 1) or low (group 2) content of Zn for 8 weeks were intratracheally instilled with 3.0 mg of ASD, followed by sacrifice at 24 hours, 2 weeks, and 1, 2 and 3 months after instillation...
2018: Folia Histochemica et Cytobiologica
https://www.readbyqxmd.com/read/29577226/neuronal-nitric-oxide-synthase-phosphorylation-induced-by-docosahexaenoic-acid-protects-dopaminergic-neurons-in-an-experimental-model-of-parkinson-s-disease
#16
Hande Parlak, Ayse Ozkan, Sayra Dilmac, Gamze Tanriover, Ozlem Ozsoy, Aysel Agar
INTRODUCTION: Docosahexaenoic acid (DHA) has been shown to have beneficial effects on Parkinson's disease (PD). The aim of this study was to investigate if the DHA acts on neurons of substantia nigra (SN) by phosphorylation of neuronal nitric oxide synthase (nNOS) in an experimental mouse model of PD. MATERIAL AND METHODS: An experimental model of PD was created by intraperitoneal injections (4 × 20 mg/kg) of the neurotoxin 1-methyl-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)...
2018: Folia Histochemica et Cytobiologica
https://www.readbyqxmd.com/read/29528086/epac1-is-involved-in-cell-cycle-progression-in-lung-cancer-through-pkc-and-cx43-regulation
#17
Qian Sun, Dai Wang, Ganghao Ai, Longben Tian, Long Zhao, Renzhen Chen, Kai Wang, Dongbei Guo, Youliang Yao, Wenzhi Liu, XIangyu Kong, Xiaoxuan Chen, Yongxing Zhang
INTRODUCTION: The exchange protein directly activated by cAMP (Epac1), a downstream target of the second messenger cAMP, modulates multiple biological effects of cAMP, alone or in cooperation with protein kinase A (PKC). Epac1 is necessary for promoting protein kinase C (PKC) translocation and activation. The aim of the study was to assess the intensity of Epac1 and protein kinase C (PKC) immunoreactivity in lung cancer and para-carcinoma tissues, and their associations with clinical-pathological indexes...
2018: Folia Histochemica et Cytobiologica
https://www.readbyqxmd.com/read/29516445/immunohistochemical-mapping-of-neurotensin-in-the-alpaca-diencephalon
#18
Manuel Lisardo Sánchez, Arturo Mangas, Luis Enrique Medina, Luis Angel Aguilar, Zaida Díaz-Cabiale, José Angel Narváez, Rafael Coveñas
INTRODUCTION: The distribution of the immunoreactive cell bodies and fibers containing neurotensin in the alpaca diencephalon was determined by an immunohistochemical technique. MATERIAL AND METHODS: The study was carried out in four male alpacas that lived at sea level. Brains of deeply anesthetized animals were fixed by perfusion with 4% paraformaldehyde. Cryostat sections were stained by a standard immunohistochemical method. RESULTS: Cell bodies containing neurotensin were observed in the zona incerta and hypothalamus...
2018: Folia Histochemica et Cytobiologica
https://www.readbyqxmd.com/read/29504116/cancer-immunotherapy-in-mice-and-humans-personal-observations
#19
Jerzy Kawiak
An experiment involving active immunotherapy of leukemia in mice and its extension to human patients with chronic lymphocytic leukemia is described. First, anticancer activation of the immune system, how it is achieved, and observations of the central blockade of the immune system in leukemia are discussed. Clinical results of antileukemia immune activation are then presented, along with a description of new attempts to remove the immune checkpoint blockade. Personal observations are presented on possible further steps to achieving more effective active immunotherapy of cancer...
2018: Folia Histochemica et Cytobiologica
https://www.readbyqxmd.com/read/29498411/rsk1-promotes-murine-breast-cancer-growth-and-metastasis
#20
Dominika Czaplinska, Monika Gorska, Kamil Mieczkowski, Grazyna Peszynska-Sularz, Anna J Zaczek, Hanna M Romanska, Rafal Sadej
INTRODUCTION: Triple-negative breast cancer (TNBC), representing over 15% of all breast cancers, has a poorer prognosis than other subtypes. There is no effective targeted treatment available for the TNBC sufferers. Ribosomal S6 kinases (RSKs) have been previously proposed as drug targets for TNBC based on observations that 85% of these tumors express activated RSKs. MATERIALS AND METHODS: Herein we examined an involvement of RSK1 (p90 ribosomal S6 kinase 1) in a regulation of TNBC growth and metastatic spread in an animal model, which closely imitates human disease...
2018: Folia Histochemica et Cytobiologica
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