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Folia Histochemica et Cytobiologica

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https://www.readbyqxmd.com/read/29577227/pathological-study-of-pulmonary-toxicity-induced-by-intratracheally-instilled-asian-sand-dust-kosa-effects-of-lowered-serum-zinc-level-on-the-toxicity
#1
Akinori Shimada, Kotaro Miyake, Yuri Kenmotsu, Kikumi Ogihara, Yuko Naya, Misaki Naota, Takehito Morita, Kenichiro Inoue, Hirohisa Takano
INTRODUCTION: We have previously reported that Asian sand dust (ASD) induced acute and chronic inflammatory changes in the lung of mice. Zinc (Zn) is reported to influence inflammation and wound healing. The purpose of the study was to assess the effects of lowered serum Zn levels on the lung toxicity induced by ASD. MATERIAL AND METHODS: Mice that were fed diets containing normal (group 1) or low (group 2) content of Zn for 8 weeks were intratracheally instilled with 3...
March 26, 2018: Folia Histochemica et Cytobiologica
https://www.readbyqxmd.com/read/29577226/neuronal-nitric-oxide-synthase-phosphorylation-induced-by-docosahexaenoic-acid-protects-dopaminergic-neurons-in-an-experimental-model-of-parkinson-s-disease
#2
Hande Parlak, Ayse Ozkan, Sayra Dilmac, Gamze Tanriover, Ozlem Ozsoy, Aysel Agar
INTRODUCTION: Docosahexaenoic acid (DHA) has been shown to have beneficial effects on Parkinson's disease (PD). The aim of this study was to investigate if the DHA acts on neurons of substantia nigra (SN) by phosphorylation of neuronal nitric oxide synthase (nNOS) in an experimental mouse model of PD. MATERIAL AND METHODS: An experimental model of PD was created by intraperitoneal injections (4 x 20 mg/kg) of the neurotoxin 1-methyl-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)...
March 26, 2018: Folia Histochemica et Cytobiologica
https://www.readbyqxmd.com/read/29528086/epac1-is-involved-in-cell-cycle-progression-in-lung-cancer-through-pkc-and-cx43-regulation
#3
Qian Sun, Dai Wang, Ganghao Ai, Longben Tian, Long Zhao, Renzhen Chen, Kai Wang, Gongbei Guo, Youliang Yao, Wenzhi Liu, XIangyu Kong, Xiaoxuan Chen, Yongxing Zhang
INTRODUCTION: The exchange protein directly activated by cAMP (Epac1), a downstream target of the second messenger cAMP, modulates multiple biological effects of cAMP, alone or in cooperation with protein kinase A (PKC). Epac1 is necessary for promoting protein kinase C (PKC) translocation and activation. The aim of the study was to assess the intensity of Epac1 and protein kinase C (PKC) immunoreactivity in lung cancer and para-carcinoma tissues, and their associations with clinical-pathological indexes...
March 12, 2018: Folia Histochemica et Cytobiologica
https://www.readbyqxmd.com/read/29516445/immunohistochemical-mapping-of-neurotensin-in-the-alpaca-diencephalon
#4
Manuel Lisardo Sánchez, Arturo Mangas, Luis Enrique Medina, Luis Angel Aguilar, Zaida Díaz-Cabiale, José Angel Narváez, Rafael Coveñas
INTRODUCTION: The distribution of the immunoreactive cell bodies and fibers containing neurotensin in the alpaca diencephalon was determined by an immunohistochemical technique. MATERIAL AND METHODS: The study was carried out in four male alpacas that lived at sea level. Brains of deeply anesthetized animals were fixed by perfusion with 4% paraformaldehyde. Cryostat sections were stained by a standard IHC method. RESULTS: Cell bodies containing neurotensin were observed in the zona incerta and hypothalamus...
March 8, 2018: Folia Histochemica et Cytobiologica
https://www.readbyqxmd.com/read/29504116/cancer-immunotherapy-in-mice-and-humans-personal-observations
#5
Jerzy Kawiak
An experiment involving active immunotherapy of leukemia in mice and its extension to human patients with chronic lymphocytic leukemia is described. First, anticancer activation of the immune system, how it is achieved, and observations of the central blockade of the immune system in leukemia are discussed. Clinical results of antileukemia immune activation are then presented, along with a description of new attempts to remove the immune checkpoint blockade. Personal observations are presented on possible further steps to achieving more effective active immunotherapy of cancer...
March 5, 2018: Folia Histochemica et Cytobiologica
https://www.readbyqxmd.com/read/29498411/rsk1-promotes-murine-breast-cancer-growth-and-metastasis
#6
Dominika Czaplinska, Monika Górska, Kamil Mieczkowski, Grazyna Peszynska-Sularz, Anna J Zaczek, Hanna M Romanska, Rafal Sadej
INTRODUCTION: Triple-negative breast cancer (TNBC), representing over 15% of all breast cancers, has a poorer prognosis than other subtypes. There is no effective targeted treatment available for the TNBC sufferers. Ribosomal S6 kinases (RSKs) have been previously proposed as drug targets for TNBC based on observations that 85% of these tumors express activated RSKs. MATERIALS AND METHODS: Herein we examined an involvement of RSK1 (p90 ribosomal S6 kinase 1) in a regulation of TNBC growth and metastatic spread in an animal model, which closely imitates human disease...
March 2, 2018: Folia Histochemica et Cytobiologica
https://www.readbyqxmd.com/read/29417981/immunoexpression-of-iga-receptors-cd89-cd71-in-dermatitis-herpetiformis
#7
Justyna Gornowicz-Porowska, Agnieszka Seraszek-Jaros, Monika Bowszyc-Dmochowska, Elżbieta Kaczmarek, Marian Dmochowski
INTRODUCTION: The role of IgA receptors in dermatitis herpetiformis (DH) pathogenesis is still unknown. CD89 and CD71 may be associated with immune response during DH development. The purpose of this study was to perform semiquantitative analysis of simultaneous immunoexpression of CD89 and CD71 in DH and IgA/neutrophil-mediated non-DH dermatoses (IgAN) in relation to specific IgA autoantibodies/antibodies (tissue and epidermal transglutaminases, nonapeptides of gliadin - eTG/tTG/npG) as well neutrophil activation via the release of neutrophil elastase (NE)...
February 8, 2018: Folia Histochemica et Cytobiologica
https://www.readbyqxmd.com/read/28691730/effects-of-colocynth-alkaloids-and-glycosides-on-wistar-rats-fed-high-fat-diet-a-biochemical-and-morphological-study
#8
Zahia Birem, Khadidja Tabani, Farid Lahfa, Rabah Djaziri, Fatima Hadjbekkouche, Elhadj Ahmed Koceir, Naima Omari
INTRODUCTION: . In traditional medicine, Citrullus colocynthis is used to treat diabetes, hyperlipidemia, cardiovascular diseases, inflammation, and oxidative stress, all of which can appear when a diet rich in vegetable fats, such as palm oil, is continuously consumed. Such high-fat diets are chronic stressors of the hypothalamic-pituitary-adrenal axis. The objective of our study was to analyze and evaluate the effects of colocynth total alkaloids and glycosides on metabolic, hormonal, and structural disorders of the adrenal medulla in Wistar rats fed a high-fat diet...
July 10, 2017: Folia Histochemica et Cytobiologica
https://www.readbyqxmd.com/read/28636071/the-role-of-homocysteine-in-seminal-vesicles-remodeling-in-rat
#9
Adel Ghoul, Elara Moudilou, Mohamed El Hadi Cherifi, Fouzia Zerrouk, Billel Chaouad, Anissa Moulahoum, Souhila Aouichat-Bouguerra, Khira Othmani, Jean-Marie Exbrayat, Yasmina Benazzoug
INTRODUCTION: Elevated plasma homocysteine (Hcy) levels have been associated with several tissue injuries including heart and liver fibrosis. In these diseases, hyperhomocysteinemia (Hhcy) plays a major role in modulating the alteration of the balance between matrix metalloproteinases (MMP) and tissue inhibitors of metalloproteinases (TIMPs), leading to the pathological accumulation of extracellular matrix (ECM) proteins. Since the effect of Hhcy on ECM of seminal vesicle was not studied, the aim of our research was to check if Hcy can induce a remodeling within seminal vesicles ECM...
June 21, 2017: Folia Histochemica et Cytobiologica
https://www.readbyqxmd.com/read/28612341/cardiomyocyte-marker-expression-in-dogs-with-left-atrial-enlargement-due-to-dilated-cardiomyopathy-or-myxomatous-mitral-valve-disease
#10
Izabela Janus, Malgorzata Kandefer-Gola, Rafal Ciaputa, Agnieszka Noszczyk-Nowak, Urszula Paslawska, Massimiliano Tursi, Marcin Nowak
INTRODUCTION: Dilated cardiomyopathy (DCM) and myxomatous mitral valve disease (MMVD) are common heart conditions in dogs. They have different etiology and pathogenesis and although other studies focused on changes in the left ventricles of the affected hearts, the aim of our study was to assess the expressions of some intrinsic proteins in the enlarged left atria. MATERIAL AND METHODS: We performed an immunohistochemical analysis of left atrial specimens obtained from 15 dogs with DCM, 35 dogs with MMVD and six control dogs...
June 14, 2017: Folia Histochemica et Cytobiologica
https://www.readbyqxmd.com/read/28518212/evaluation-of-cytotoxicity-and-ph-changes-generated-by-various-dental-pulp-capping-materials-an-in-vitro-study
#11
Elzbieta Luczaj-Cepowicz, Grazyna Marczuk-Kolada, Malgorzata Pawinska, Marta Obidzinska, Adam Holownia
INTRODUCTION: Various materials are used in direct dental pulp capping method. Their biocompatibility and alkalizing abilities are of primary importance affecting therapeutic effects. The aim of this study was to evaluate and compare the cytotoxicity of various pulp-capping materials on human gingival fibroblasts and investigate the pH changes induced by these materials. MATERIAL AND METHODS: Human gingival fibroblasts were cultured with nine direct pulp materials using culture plate inserts...
May 18, 2017: Folia Histochemica et Cytobiologica
https://www.readbyqxmd.com/read/28518211/inhibition-of-egfr-nuclear-shuttling-decreases-irradiation-resistance-in-hela-cells
#12
Hong Wei, Zijie Zhu, Longtao Lu
INTRODUCTION: Cervical cancer is a leading cause of mortality in women worldwide. The resistance to irradiation at the advanced stage is the main reason for the poor prognosis and high mortality. This work aims to elucidate the molecular mechanism underlying the radio-resistance. MATERIAL AND METHODS: In this study, we determined the pEGFR-T654 and pDNA-PK-T2609 expression level change in irradiated HeLa cells treated with T654 peptide, a nuclear localization signal (NLS) inhibitor, to inhibit EGFR nuclear transport...
May 18, 2017: Folia Histochemica et Cytobiologica
https://www.readbyqxmd.com/read/29363733/generation-of-specific-antisera-directed-against-d-amino-acids-focus-on-the-neuroanatomical-distribution-of-d-glutamate-and-other-d-amino-acids
#13
Rafael Coveñas, Arturo Mangas, Manuel Lisardo Sánchez, Diana Cadena, Marianne Husson, Michel Geffard
This review updates the findings about the anatomical distribution (using immunohistochemical techniques) and possible functions of D-glutamate in the central nervous system of mammals, as well as compares the distribution of D-glutamate with the distribution of the most studied D-amino acids: D-serine and D-aspartate. The protocol used to obtain highly specific antisera directed against D-amino acids is also reported. Immunoreactivity for D-glutamate was found in dendrites and cell bodies, but not in nerve fibers...
2017: Folia Histochemica et Cytobiologica
https://www.readbyqxmd.com/read/29333597/tp53-polymorphism-in-plasma-cell-myeloma
#14
Szymon Andrzej Zmorzynski, Iwona Korszen-Pilecka, Magdalena Wojcierowska-Litwin, Barbara Kwiatkowska-Drabik, Malgorzata Luterek, Sylwia Chocholska, Dorota Koczkodaj, Sylwia Popek, Malgorzata Michalak-Wojnowska, Grazyna Swiderska-Kolacz, Joanna Januszewska, Iwona Surowiec, Waldemar Tomczak, Marek Hus, Anna Dmoszynska, Marcin Pasiarski, Katarzyna Poniewierska-Jasak, Katarzyna Cieplinska, Olga Jankowska-Lecka, Agata Anna Filip
INTRODUCTION: Significant and accessible predictive factors for bortezomib treatment in plasma cell myeloma (PCM) are still lacking. TP53 codon 72 polymorphism (P72R) results in proline (P) or arginine (R) at 72 amino acid position, which causes synthesis of proteins with distinct functions. The aims of our study were to: 1) analyze whether this polymorphism is associated with an increased risk of PCM; 2) study whether the P72R polymorphism affects overall survival (OS) among PCM patients; 3) assess the possible association of the P72R polymorphism with sensitivity to bortezomib in cell cultures derived from PCM patients...
2017: Folia Histochemica et Cytobiologica
https://www.readbyqxmd.com/read/29297566/immunohistochemical-characteristics-of-neurons-in-the-ganglia-of-the-greater-splanchnic-nerve-of-the-pig
#15
Jamal Nourinezhad, Piotr Podlasz, Krzysztof Wasowicz
INTRODUCTION: Greater splanchnic nerve (GSN) is by far the largest of the splanchnic nerves and connects the paravertebral and prevertebral ganglia to transmit the majority of nociceptive information from the viscera. Despite its importance, the immunohistochemical features of the porcine GSN neurons have not yet been examined. Therefore, the aim of the study was to investigate the neurochemistry of the porcine GSN neurons and to compare their neurochemical coding with those of the paravertebral and prevertebral ganglia...
2017: Folia Histochemica et Cytobiologica
https://www.readbyqxmd.com/read/29261224/mitochondrial-sirtuins-in-the-rat-adrenal-gland-location-within-the-glands-of-males-and-females-hormonal-and-developmental-regulation-of-gene-expressions
#16
Piotr Celichowski, Karol Jopek, Marta Szyszka, Marianna Tyczewska, Ludwik K Malendowicz, Marcin Rucinski
INTRODUCTION: Sirtuins are NAD dependent class III histone deacetylases. In adrenal cortex mitochondria are able to transform - via nicotinamide nucleotide transhydrogenase (NNT) - NAD into NADPH, which is required for steroidogenesis. These findings suggest that sirtuins expressed in mitochondria, Sirt3, Sirt4 and Sirt5, may be associated with adrenal steroidogenesis. Therefore, the purpose of this study was to characterize the expression of mitochondrial sirtuins (Sirt3-5) in individual compartments of rat adrenal cortex, their developmental regulation and to demonstrate whether their expression is dependent on adrenocorticotrophic hormone (ACTH) and Nampt (nicotinamide phosphoribosyltransferase also known as visfatin/PBEF), the rate-limiting enzyme in the regulation of mammalian NAD synthesis...
2017: Folia Histochemica et Cytobiologica
https://www.readbyqxmd.com/read/28994098/the-impact-of-antiandrogen-flutamide-on-the-hypoxia-inducible-factor-1a-and-vascular-endothelial-growth-factor-a-gene-and-protein-expression-in-the-pig-placenta-during-late-pregnancy
#17
Elzbieta Czaja, Iwona Wieciech-Rojkiewicz, Katarzyna Knapczyk-Stwora, Malgorzata Grzesiak, Maria Slomczynska
INTRODUCTION: In contrast to estradiol action, little is known about androgen signaling in placental development. The purpose of this study was to evaluate the impact of diminished androgen action on hypoxia inducible factor 1a (HIF-1a) and vascular endothelial growth factor A (VEGFA) protein expression as well as their mRNAs in the structures of fetal and maternal parts of porcine placenta during late pregnancy. MATERIAL AND METHODS: Pregnant pigs were injected daily with antiandrogen flutamide, at a dose of 50 mg/kg body weight at different stages of pregnancy: between gestational days 83-89 (90 dpc) and 101-107 (108 dpc)...
2017: Folia Histochemica et Cytobiologica
https://www.readbyqxmd.com/read/28994097/reliability-of-histopathological-examination-and-immunohistochemistry-of-a-single-biopsy-for-evaluation-of-endometrial-health-in-icelandic-mares
#18
Monika Sikora, Marcin Nowak, Henryk Racheniuk, Katarzyna Wojtysiak, Roland Kozdrowski
INTRODUCTION: Endometritis and endometrosis have been and still are the major reasons for infertility in mares. The diagnosis of endometritis can be based on cytology and microbiology, but endometrial biopsy is still the only way to diagnose endometrosis in the mare. Our study attempted to determine if a single biopsy using his-topathology and immunohistochemistry is sufficient to ascertain reasons for infertility in Icelandic mares. The objectives of this study were to examine the relationship between deviations in endometrial biopsies in terms of prostaglandin-endoperoxide synthase-2 (PTGS-2) and fibronectin expression and polymorphonuclear cells (PMNs) infiltration, as well as scoring degeneration in two endometrial biopsies...
2017: Folia Histochemica et Cytobiologica
https://www.readbyqxmd.com/read/28994096/impaired-expression-of-testicular-androgen-receptor-and-collagen-fibers-in-the-testis-of-diabetic-rats-under-haart-the-role-of-hypoxis-hemerocallidea
#19
Onanuga O Ismail, Jegede A Isaac, Offor Ugochukwu, Ogedengbe O Oluwatosin, Peter I Aniekan, Naidu C S Edwin, Azu O Onyemaechi
INTRODUCTION: Wide spectrum of alterations associated with highly active antiretroviral therapy (HAART) has been reported. The current study aimed at evaluating the role of Hypoxis hemerocallidea (HH) aqueous extract on the testosterone levels, expression of androgen receptors and collagen fibers in the testes of streptozoto-cin-nicotinamide-induced diabetic rats under HAART regimen. MATERIAL AND METHODS: Sixty two adult male Sprague-Dawley rats (189.0 ± 4.5 g) were divided into eight groups (8 animals in each treatment groups and 6 rats in the control group)...
2017: Folia Histochemica et Cytobiologica
https://www.readbyqxmd.com/read/28994095/repression-of-the-notch-pathway-prevents-liver-damage-in-streptozotocin-induced-diabetic-mice
#20
Eda Acikgoz, Huseyin Aktug, Gurkan Yigitturk, Kenan Demir, Ummu Guven, Fahriye Duzagac, Fatih Oltulu, Altug Yavasoglu, Gulperi Oktem
INTRODUCTION: Sunitinib is an oral inhibitor of vascular endothelial growth factor that is used to treat a variety of cancer. There are limited data regarding the effect of sunitinib on diabetes. In the liver, Notch signaling plays an important role in liver tissue development and homeostasis and its dysfunction is associated with liver pathol-ogies. The aim of the present study is to investigate the effects of sunitinib on streptozotocin (STZ)-induced diabetic liver in mice models. MATERIAL AND METHODS: An experimental diabetes mellitus (DM) model was created in 28 male CD-1 mice...
2017: Folia Histochemica et Cytobiologica
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