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Natural Product Reports

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https://www.readbyqxmd.com/read/28217773/finding-food-how-marine-invertebrates-use-chemical-cues-to-track-and-select-food
#1
REVIEW
Michiya Kamio, Charles D Derby
Benthic marine invertebrates sense molecules from other organisms and use these molecules to find and evaluate the organisms as sources of food. These processes depend on the detection and discrimination of molecules carried in sea water around and in the mouths of these animals. To understand these processes, researchers have studied how molecules released from food distribute in the sea water as a plume, how animals respond to the plume, the molecular identity of the attractants in the plume, the effect of turbulence on food-searching success, and how animals evaluate the quality of food and make decisions to eat or not...
February 20, 2017: Natural Product Reports
https://www.readbyqxmd.com/read/28205661/fungal-volatiles-a-survey-from-edible-mushrooms-to-moulds
#2
REVIEW
Jeroen S Dickschat
Covering: up to January 2017This review gives a comprehensive overview of the production of fungal volatiles, including the history of the discovery of the first compounds and their distribution in the various investigated strains, species and genera, as unravelled by modern analytical methods. Biosynthetic aspects and the accumulated knowledge about the bioactivity and biological functions of fungal volatiles are also covered. A total number of 325 compounds is presented in this review, with 247 cited references...
February 16, 2017: Natural Product Reports
https://www.readbyqxmd.com/read/28180228/dyotropic-rearrangements-in-natural-product-total-synthesis-and-biosynthesis
#3
Cedric L Hugelshofer, Thomas Magauer
Covering: up to January 2017This highlight article presents some recent examples of dyotropic rearrangements, which were applied in natural product total synthesis or proposed to occur in biosyntheses. The implementation of dyotropic reactions in the preparation of complex natural products has resulted in the development of elegant synthetic routes, and thereby highlights the utility of these powerful, yet relatively underrepresented, transformations.
February 9, 2017: Natural Product Reports
https://www.readbyqxmd.com/read/28180225/rediscovering-the-octapeptins
#4
REVIEW
Tony Velkov, Kade D Roberts, Jian Li
Covering: 1975 up to the end of 2016The decline in the discovery and development of novel antibiotics has resulted in the emergence of bacteria that are resistant to almost all available antibiotics. Currently, polymyxin B and E (colistin) are being used as the last-line therapy against life-threatening infections, unfortunately resistance to polymyxins in both the community and hospital setting is becoming more common. Octapeptins are structurally related non-ribosomal lipopeptide antibiotics that do not exhibit cross-resistance with polymyxins and have a broader spectrum of activity that includes Gram-positive bacteria...
February 9, 2017: Natural Product Reports
https://www.readbyqxmd.com/read/28125109/fluorescent-natural-products-as-probes-and-tracers-in-biology
#5
REVIEW
Romain Duval, Christophe Duplais
Covering: 1985 up to the end of 2016Fluorescence is a remarkable property of many natural products in addition to their medicinal and biological values. Herein, we provide a review on these peculiar secondary metabolites to stimulate prospecting of them as original fluorescent tracers, endowed with unique photophysical properties and with applications in most fields of biology. The compounds are spectrally categorized (i.e. fluorescing from violet to the near infra-red) and further structurally classified within each category...
January 26, 2017: Natural Product Reports
https://www.readbyqxmd.com/read/28079908/hot-off-the-press
#6
Robert A Hill, Andrew Sutherland
A personal selection of 32 recent papers is presented covering various aspects of current developments in bioorganic chemistry and novel natural products such as hitorin A from Chloranthus japonicus.
January 12, 2017: Natural Product Reports
https://www.readbyqxmd.com/read/27907217/natural-products-from-myxobacteria-novel-metabolites-and-bioactivities
#7
REVIEW
J Herrmann, A Abou Fayad, R Müller
Covering: 2011-July 2016Myxobacteria are a rich source for structurally diverse secondary metabolites with intriguing biological activities. Here we report on new natural products that were isolated from myxobacteria in the period of 2011 to July 2016. Some examples of recent advances on modes-of-action are also summarised along with a more detailed overview on five compound classes currently assessed in preclinical studies.
December 1, 2016: Natural Product Reports
https://www.readbyqxmd.com/read/27874907/natural-products-as-mediators-of-disease
#8
Neha Garg, Tal Luzzatto-Knaan, Alexey V Melnik, Andrés Mauricio Caraballo-Rodríguez, Dimitrios J Floros, Daniel Petras, Rachel Gregor, Pieter C Dorrestein, Vanessa V Phelan
Covering: up to 2016Humans are walking microbial ecosystems, each harboring a complex microbiome with the genetic potential to produce a vast array of natural products. Recent sequencing data suggest that our microbial inhabitants are critical for maintaining overall health. Shifts in microbial communities have been correlated to a number of diseases including infections, inflammation, cancer, and neurological disorders. Some of these clinically and diagnostically relevant phenotypes are a result of the presence of small molecules, yet we know remarkably little about their contributions to the health of individuals...
February 1, 2017: Natural Product Reports
https://www.readbyqxmd.com/read/28051215/back-cover
#9
(no author information available yet)
No abstract text is available yet for this article.
January 4, 2017: Natural Product Reports
https://www.readbyqxmd.com/read/28051214/contents-list
#10
(no author information available yet)
No abstract text is available yet for this article.
January 4, 2017: Natural Product Reports
https://www.readbyqxmd.com/read/28051208/front-cover
#11
(no author information available yet)
No abstract text is available yet for this article.
January 4, 2017: Natural Product Reports
https://www.readbyqxmd.com/read/27813539/triterpenoids
#12
REVIEW
Robert A Hill, Joseph D Connolly
Covering: 2013. Previous review: Nat. Prod. Rep., 2015, 29, 1028-1065This review covers the isolation and structure determination of triterpenoids reported during 2013 including squalene derivatives, lanostanes, holostanes, cycloartanes, cucurbitanes, dammaranes, euphanes, tirucallanes, tetranortriterpenoids, quassinoids, lupanes, oleananes, friedelanes, ursanes, hopanes, serratanes, isomalabaricanes and saponins; 350 references are cited.
January 4, 2017: Natural Product Reports
https://www.readbyqxmd.com/read/27782262/pyrrolizidine-alkaloids-occurrence-biology-and-chemical-synthesis
#13
REVIEW
Jeremy Robertson, Kiri Stevens
Covering: 2013 up to the end of 2015This review covers the isolation and structure of new pyrrolizidines; pyrrolizidine biosynthesis; biological activity, including the occurrence of pyrrolizidines as toxic components or contaminants in foods and beverages; and formal and total syntheses of naturally-occurring pyrrolizidine alkaloids and closely related non-natural analogues.
January 4, 2017: Natural Product Reports
https://www.readbyqxmd.com/read/27759131/pyranonaphthoquinones-isolation-biology-and-synthesis-an-update
#14
REVIEW
Briar J Naysmith, Paul A Hume, Jonathan Sperry, Margaret A Brimble
Covering: 2008 to 2015. A review on the isolation, biological activity and synthesis of pyranonaphthoquinone natural products from 2008-2015 is providedThis review discusses the isolation, biological activity and synthesis of pyranonaphthoquinone natural products, covering the years 2008-2015. The pyranonaphthoquinones are a group of metabolites sharing a common naphtho[2,3-c]pyran-5,10-dione ring system that have been isolated from a wide range of microorganisms, plants and insects. In addition to their synthetically challenging molecular structures, pyranonaphthoquinones exhibit a wide array of biological activity, including anti-bacterial, anti-fungal and anti-cancer properties...
January 4, 2017: Natural Product Reports
https://www.readbyqxmd.com/read/27604382/comparative-mass-spectrometry-based-metabolomics-strategies-for-the-investigation-of-microbial-secondary-metabolites
#15
REVIEW
Brett C Covington, John A McLean, Brian O Bachmann
Covering: 2000 to 2016The labor-intensive process of microbial natural product discovery is contingent upon identifying discrete secondary metabolites of interest within complex biological extracts, which contain inventories of all extractable small molecules produced by an organism or consortium. Historically, compound isolation prioritization has been driven by observed biological activity and/or relative metabolite abundance and followed by dereplication via accurate mass analysis. Decades of discovery using variants of these methods has generated the natural pharmacopeia but also contributes to recent high rediscovery rates...
January 4, 2017: Natural Product Reports
https://www.readbyqxmd.com/read/27467076/diterpenoids-of-terrestrial-origin
#16
James R Hanson
Covering January to December 2015. Previous review; Nat. Prod. Rep., 2015, 32, 1654-1663.This review covers the isolation and chemistry of diterpenoids from terrestrial as opposed to marine sources and includes labdanes, clerodanes, abietanes, pimaranes, kauranes, cembranes and their cyclization products. There are 214 references.
October 28, 2016: Natural Product Reports
https://www.readbyqxmd.com/read/27433555/clerodane-diterpenes-sources-structures-and-biological-activities
#17
Rongtao Li, Susan L Morris-Natschke, Kuo-Hsiung Lee
Covering: 1990 to 2015The clerodane diterpenoids are a widespread class of secondary metabolites and have been found in several hundreds of plant species from various families and in organisms from other taxonomic groups. These substances have attracted interest in recent years due to their notable biological activities, particularly insect antifeedant properties. In addition, the major active clerodanes of Salvia divinorum can be used as novel opioid receptor probes, allowing greater insight into opioid receptor-mediated phenomena, as well as opening additional areas for chemical investigation...
October 28, 2016: Natural Product Reports
https://www.readbyqxmd.com/read/27367973/comparison-of-analytical-techniques-for-the-identification-of-bioactive-compounds-from-natural-products
#18
Łukasz Cieśla, Ruin Moaddel
Covering: 2000 to 2016Natural product extracts are a rich source of bioactive compounds. As a result, the screening of natural products for the identification of novel biologically active metabolites has been an essential part of several drug discovery programs. It is estimated that more than 70% of all drugs approved from 1981 and 2006, were either derived from or structurally similar to nature based compounds indicating the necessity for the development of a rapid method for the identification of novel compounds from plant extracts...
October 28, 2016: Natural Product Reports
https://www.readbyqxmd.com/read/27307039/antimycin-type-depsipeptides-discovery-biosynthesis-chemical-synthesis-and-bioactivities
#19
Joyce Liu, Xuejun Zhu, Seong Jong Kim, Wenjun Zhang
Covering: up to 2016Antimycin-type depsipeptides are a family of natural products with great structural diversity and outstanding biological activities. These compounds have typically been isolated from actinomycetes and are generated from hybrid nonribosomal peptide synthetase (NRPS)-polyketide synthase (PKS) assembly lines. This review covers the literature on the four classes of antimycin-type depsipeptides, which differ by macrolactone ring size, and it discusses the discovery, biosynthesis, chemical synthesis, and biological activities of this family of compounds...
October 28, 2016: Natural Product Reports
https://www.readbyqxmd.com/read/27785514/hot-off-the-press
#20
Robert A Hill, Andrew Sutherland
A personal selection of 32 recent papers is presented covering various aspects of current developments in bioorganic chemistry and novel natural products such as kanamienamide from the marine cyanobacterium Moorea bouillonii.
October 27, 2016: Natural Product Reports
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