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Natural Product Reports

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https://www.readbyqxmd.com/read/28820533/actinomycetes-still-a-source-of-novel-antibiotics
#1
REVIEW
Olga Genilloud
Covering: 2006 to 2017Actinomycetes have been, for decades, one of the most important sources for the discovery of new antibiotics with an important number of drugs and analogs successfully introduced in the market and still used today in clinical practice. The intensive antibacterial discovery effort that generated the large number of highly potent broad-spectrum antibiotics, has seen a dramatic decline in the large pharma industry in the last two decades resulting in a lack of new classes of antibiotics with novel mechanisms of action reaching the clinic...
August 18, 2017: Natural Product Reports
https://www.readbyqxmd.com/read/28808718/covalent-modification-of-biological-targets-with-natural-products-through-paal-knorr-pyrrole-formation
#2
Alexander Kornienko, James J La Clair
Covering: up to June 2017Natural products and endogenous metabolites engage specific targets within tissues and cells through complex mechanisms. This review examines the extent to which natural systems have adopted the Paal-Knorr reaction to engage nucleophilic amine groups within biological targets. Current understanding of this mode of reactivity is limited by only a few examples of this reaction in a biological context. This highlight is intended to stimulate the scientific community to identify potential research directions and applications of the Paal-Knorr reaction in native and engineered biological systems...
August 15, 2017: Natural Product Reports
https://www.readbyqxmd.com/read/28799605/enabling-syntheses-of-diterpenoid-alkaloids-and-related-diterpenes-by-an-oxidative-dearomatization-diels-alder-cycloaddition-strategy
#3
Xiao-Yu Liu, Yong Qin
Covering: 2015 to March 2017ortho-Benzoquinones generated from dearomatization of aromatic compounds are highly reactive intermediates in organic synthesis. One of their most important applications involves the participation in Diels-Alder cycloadditions, facilitating rapid access to molecular complexity. This powerful strategy has recently been utilized in the syntheses of diverse diterpenoid alkaloids and their biogenetically relevant diterpenes, which is the subject of this Highlight.
August 11, 2017: Natural Product Reports
https://www.readbyqxmd.com/read/28770915/expansion-of-chemical-space-for-natural-products-by-uncommon-p450-reactions
#4
REVIEW
Xingwang Zhang, Shengying Li
Covering: 2000 to 2017Cytochrome P450 enzymes (P450s) are the most versatile biocatalysts in nature. The catalytic competence of these extraordinary hemoproteins is broadly harnessed by numerous chemical defenders such as bacteria, fungi, and plants for the generation of diverse and complex natural products. Rather than the common tailoring reactions (e.g. hydroxylation and epoxidation) mediated by the majority of biosynthetic P450s, in this review, we will focus on the unusual P450 enzymes in relation to new chemistry, skeleton construction, and structure re-shaping via their own unique catalytic power or the intriguing protein-protein interactions between P450s and other proteins...
August 3, 2017: Natural Product Reports
https://www.readbyqxmd.com/read/28758170/cytochromes-p450-for-natural-product-biosynthesis-in-streptomyces-sequence-structure-and-function
#5
REVIEW
Jeffrey D Rudolf, Chin-Yuan Chang, Ming Ma, Ben Shen
Covering: up to January 2017Cytochrome P450 enzymes (P450s) are some of the most exquisite and versatile biocatalysts found in nature. In addition to their well-known roles in steroid biosynthesis and drug metabolism in humans, P450s are key players in natural product biosynthetic pathways. Natural products, the most chemically and structurally diverse small molecules known, require an extensive collection of P450s to accept and functionalize their unique scaffolds. In this review, we survey the current catalytic landscape of P450s within the Streptomyces genus, one of the most prolific producers of natural products, and comprehensively summarize the functionally characterized P450s from Streptomyces...
July 31, 2017: Natural Product Reports
https://www.readbyqxmd.com/read/28758169/diterpenoids-from-isodon-species-an-update
#6
REVIEW
Miao Liu, Wei-Guang Wang, Han-Dong Sun, Jian-Xin Pu
Covering: December 2005 to June 2016. Previous review: Nat. Prod. Rep., 2006, 23, 673-698Over the last decade, great efforts have been made to conduct phytochemistry research on the genus Isodon, which have led to the isolation and identification of a number of diterpenoids. At the same time, these newly reported diterpenoids with diverse structures have led to new findings on their biological functions and chemical synthesis research. In this update, we review more than 600 new diterpenoids, including their structures, classifications, biogenetic pathways, bioactivities, and chemical synthesis...
July 31, 2017: Natural Product Reports
https://www.readbyqxmd.com/read/28766670/contents-list
#7
(no author information available yet)
No abstract text is available yet for this article.
August 2, 2017: Natural Product Reports
https://www.readbyqxmd.com/read/28766642/front-cover
#8
(no author information available yet)
No abstract text is available yet for this article.
August 2, 2017: Natural Product Reports
https://www.readbyqxmd.com/read/28766634/back-cover
#9
(no author information available yet)
No abstract text is available yet for this article.
August 2, 2017: Natural Product Reports
https://www.readbyqxmd.com/read/28737179/total-synthesis-of-the-dictyodendrins-as-an-arena-to-highlight-emerging-synthetic-technologies
#10
REVIEW
Wenhan Zhang, Joseph M Ready
Covering: 1993-2017This review discusses the isolation, biological activity, and syntheses of the dictyodendrin class of natural products, covering the years 1993-2017. The dictyodendrins are a family of alkaloids isolated from marine sponges, Dictyodendrilla verongiformis and Ianthella sp., which possess a highly substituted pyrrolo[2,3-c]carbazole core at the phenol or quinone oxidation states. Dictyodendrins exhibit a wide range of biological activities, such as telomerase inhibition, BACE1 enzyme inhibition, and cytotoxicity against several cancer cell lines...
August 2, 2017: Natural Product Reports
https://www.readbyqxmd.com/read/28717803/hot-off-the-press
#11
Robert A Hill, Andrew Sutherland
A personal selection of 32 recent papers is presented covering various aspects of current developments in bioorganic chemistry and novel natural products such as svetamycin B from a Streptomyces species.
August 2, 2017: Natural Product Reports
https://www.readbyqxmd.com/read/28678294/correction-uncovering-the-structures-of-modular-polyketide-synthases
#12
Kira J Weissman
Correction for 'Uncovering the structures of modular polyketide synthases' by Kira J. Weissman, Nat. Prod. Rep., 2015, 32, 436-453.
August 2, 2017: Natural Product Reports
https://www.readbyqxmd.com/read/28642945/nonribosomal-peptide-synthetase-biosynthetic-clusters-of-eskape-pathogens
#13
REVIEW
Andrew M Gulick
Covering: up to 2017.Natural products are important secondary metabolites produced by bacterial and fungal species that play important roles in cellular growth and signaling, nutrient acquisition, intra- and interspecies communication, and virulence. A subset of natural products is produced by nonribosomal peptide synthetases (NRPSs), a family of large, modular enzymes that function in an assembly line fashion. Because of the pharmaceutical activity of many NRPS products, much effort has gone into the exploration of their biosynthetic pathways and the diverse products they make...
August 2, 2017: Natural Product Reports
https://www.readbyqxmd.com/read/28497823/natural-products-modulating-the-herg-channel-heartaches-and-hope
#14
REVIEW
Jadel M Kratz, Ulrike Grienke, Olaf Scheel, Stefan A Mann, Judith M Rollinger
Covering: 1996-December 2016The human Ether-à-go-go Related Gene (hERG) channel is a voltage-gated potassium channel playing an essential role in the normal electrical activity in the heart. It is involved in the repolarization and termination of action potentials in excitable cardiac cells. Mutations in the hERG gene and hERG channel blockage by small molecules are associated with increased risk of fatal arrhythmias. Several drugs have been withdrawn from the market due to hERG channel-related cardiotoxicity...
August 2, 2017: Natural Product Reports
https://www.readbyqxmd.com/read/28497152/the-sedoheptulose-7-phosphate-cyclases-and-their-emerging-roles-in-biology-and-ecology
#15
REVIEW
Andrew R Osborn, Kelsey M Kean, P Andrew Karplus, Taifo Mahmud
Covering up to: 1999-2016This highlight covers a family of enzymes of growing importance, the sedoheptulose 7-phosphate cyclases, initially of interest due to their involvement in the biosynthesis of pharmaceutically relevant secondary metabolites. More recently, these enzymes have been found throughout Prokarya and Eukarya, suggesting their broad potential biological roles in nature.
August 2, 2017: Natural Product Reports
https://www.readbyqxmd.com/read/28675405/targeting-a-cell-wall-biosynthesis-hot-spot
#16
REVIEW
Anna Müller, Anna Klöckner, Tanja Schneider
Covering: up to 2017History points to the bacterial cell wall biosynthetic network as a very effective target for antibiotic intervention, and numerous natural product inhibitors have been discovered. In addition to the inhibition of enzymes involved in the multistep synthesis of the macromolecular layer, in particular, interference with membrane-bound substrates and intermediates essential for the biosynthetic reactions has proven a valuable antibacterial strategy. A prominent target within the peptidoglycan biosynthetic pathway is lipid II, which represents a particular "Achilles' heel" for antibiotic attack, as it is readily accessible on the outside of the cytoplasmic membrane...
July 6, 2017: Natural Product Reports
https://www.readbyqxmd.com/read/28628170/recent-advances-and-perspectives-in-the-design-and-development-of-polymyxins
#17
REVIEW
Francesc Rabanal, Yolanda Cajal
Covering: 1947-early 2017, particularly from 2005-early 2017The rise of bacterial pathogens with acquired resistance to almost all available antibiotics is becoming a serious public health issue. Polymyxins, antibiotics that were mostly abandoned a few decades ago because of toxicity concerns, are ultimately considered as a last-line therapy to treat infections caused by multi-drug resistant Gram-negative bacteria. This review surveys the progress in understanding polymyxin structure, and their chemistry, mechanisms of antibacterial activity and nephrotoxicity, biomarkers, synergy and combination with other antimicrobial agents and antibiofilm properties...
July 6, 2017: Natural Product Reports
https://www.readbyqxmd.com/read/28561849/symbiosis-inspired-approaches-to-antibiotic-discovery
#18
REVIEW
Navid Adnani, Scott R Rajski, Tim S Bugni
Covering: 2010 up to 2017Life on Earth is characterized by a remarkable abundance of symbiotic and highly refined relationships among life forms. Defined as any kind of close, long-term association between two organisms, symbioses can be mutualistic, commensalistic or parasitic. Historically speaking, selective pressures have shaped symbioses in which one organism (typically a bacterium or fungus) generates bioactive small molecules that impact the host (and possibly other symbionts); the symbiosis is driven fundamentally by the genetic machineries available to the small molecule producer...
July 6, 2017: Natural Product Reports
https://www.readbyqxmd.com/read/28375422/conformational-control-of-the-bacterial-clp-protease-by-natural-product-antibiotics
#19
REVIEW
I T Malik, H Brötz-Oesterhelt
Covering: up to 2017The bacterial Clp protease is a highly conserved and structurally versatile machine. It has gained a lot of recognition during the last decade as a novel antibacterial drug target with an unprecedented mechanism of action. Due to its complexity, there are distinct means of interfering with its natural functions and several compounds targeting this machine have been identified. In this review, we summarize the current state of knowledge about natural products deregulating Clp proteolysis, a crucial and delicate process within the cell...
July 6, 2017: Natural Product Reports
https://www.readbyqxmd.com/read/28671218/editorial-are-natural-products-the-solution-to-antimicrobial-resistance
#20
EDITORIAL
Bradley S Moore, Guy T Carter, Mark Brönstrup
No abstract text is available yet for this article.
July 1, 2017: Natural Product Reports
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