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Natural Product Reports

Maho Morita, Eric W Schmidt
Covering: up to 2018Symbiotic microbes interact with animals, often by producing natural products (specialized metabolites; secondary metabolites) that exert a biological role. A major goal is to determine which microbes produce biologically important compounds, a deceptively challenging task that often rests on correlative results, rather than hypothesis testing. Here, we examine the challenges and successes from the perspective of marine animal-bacterial mutualisms. These animals have historically provided a useful model because of their technical accessibility...
February 14, 2018: Natural Product Reports
Kevin Hung, Xirui Hu, Thomas J Maimone
Covering: 2011-2017Radical cyclizations have a rich history in organic chemistry and have been particularly generous to the field of natural product synthesis. Owing to their ability to operate in highly congested molecular quarters, and with significant functional group compatibility, these transformations have enabled the synthesis of numerous polycyclic terpenoid natural products over the past several decades. Moreover, when programmed accordingly into a synthetic plan, radical cascade processes can be used to rapidly assemble molecular complexity, much in the same way nature rapidly constructs terpene frameworks through cationic cyclization pathways...
February 8, 2018: Natural Product Reports
P Mergaert
Covering: up to 2018Antimicrobial peptides (AMPs) have been known for well over three decades as crucial mediators of the innate immune response in animals and plants, where they are involved in the killing of infecting microbes. However, AMPs have now also been found to be produced by eukaryotic hosts during symbiotic interactions with bacteria. These symbiotic AMPs target the symbionts and therefore have a more subtle biological role: not eliminating the microbial symbiont population but rather keeping it in check...
February 2, 2018: Natural Product Reports
T Hautbergue, E L Jamin, L Debrauwer, O Puel, I P Oswald
Fungal secondary metabolites are defined by bioactive properties that ensure adaptation of the fungus to its environment. Although some of these natural products are promising sources of new lead compounds especially for the pharmaceutical industry, others pose risks to human and animal health. The identification of secondary metabolites is critical to assessing both the utility and risks of these compounds. Since fungi present biological specificities different from other microorganisms, this review covers the different strategies specifically used in fungal studies to perform this critical identification...
January 31, 2018: Natural Product Reports
B Franke, J S Mylne, K J Rosengren
Covering: 1999 up to the end of 2017The small cyclic peptide SunFlower Trypsin Inhibitor-1 (SFTI-1) from sunflower seeds is the prototypic member of a novel family of natural products. The biosynthesis of these peptides is intriguing as their gene-encoded peptide backbone emerges from a precursor protein that also contains a seed storage albumin. The peptide sequence is cleaved out from the precursor and cyclised by the albumin-maturing enzymatic machinery. Three-dimensional solution NMR structures of a number of these peptides, and of the intact precursor protein preproalbumin with SFTI-1, have now been elucidated...
January 30, 2018: Natural Product Reports
Bradley S Moore
No abstract text is available yet for this article.
January 25, 2018: Natural Product Reports
Yi-Ming Shi, Helge B Bode
Covering: up to November 2017Organismic interaction is one of the fundamental principles for survival in any ecosystem. Today, numerous examples show the interaction between microorganisms like bacteria and higher eukaryotes that can be anything between mutualistic to parasitic/pathogenic symbioses. There is also increasing evidence that microorganisms are used by higher eukaryotes not only for the supply of essential factors like vitamins but also as biological weapons to protect themselves or to kill other organisms...
January 23, 2018: Natural Product Reports
Fu-Min Zhang, Shu-Yu Zhang, Yong-Qiang Tu
Covering: 2011 to July 2017.Spiroketal (spiroacetal), a common moiety in numerous natural products, drugs and functional molecules, has been a central topic in organic chemistry for a long time. Owing to their structural diversity, important bioactivity and functional irreplaceability, natural spiroketals have attracted the interest of natural product chemists, medical chemists, biological chemists, agricultural chemists, synthetic chemists, and chemical biologists. In this review, we focus on the overview of the isolation, bioactivity, biosynthesis and total synthesis of spiroketals from 2011 to July 2017...
January 22, 2018: Natural Product Reports
Robert A Hill, Andrew Sutherland
A personal selection of 32 recent papers is presented covering various aspects of current developments in bioorganic chemistry and novel natural products such as illisimonin A from Illicium simonsii.
January 19, 2018: Natural Product Reports
C Lecourt, S Dhambri, L Allievi, Y Sanogo, N Zeghbib, R Ben Othman, M-I Lannou, G Sorin, J Ardisson
Covering: 2002 to August 2017.This review highlights recent RCM reactions towards the synthesis of sterically congested natural products. It offers an insight into various synthetic targets and approaches and provides information on the evolution of catalysts as powerful tools enabling the use of increasingly challenging diene precursors.
January 18, 2018: Natural Product Reports
John W Blunt, Anthony R Carroll, Brent R Copp, Rohan A Davis, Robert A Keyzers, Michèle R Prinsep
Covering: 2016. Previous review: Nat. Prod. Rep., 2017, 34, 235-294This review covers the literature published in 2016 for marine natural products (MNPs), with 757 citations (643 for the period January to December 2016) referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms. The emphasis is on new compounds (1277 in 432 papers for 2016), together with the relevant biological activities, source organisms and country of origin...
January 16, 2018: Natural Product Reports
Jason J Chruma, Douglas J Cullen, Lydia Bowman, Patrick H Toy
Covering up to February 2017The pericarps of several species from the Zanthoxylum genus, a.k.a. the "prickly ash", have long been used for culinary purposes throughout Asia, most notably in the Sichuan (previously Szechuan) cuisine of Southwestern China, due to the unique tingling and numbing orosensations arising from a collection of polyunsaturated fatty acid amide (alkamide) constituents. The past decade has experienced dramatically increased academic and industrial interest in these pungent Zanthoxylum-derived alkamides, with a concomitant explosion in studies aimed at elucidating the specific biochemical mechanisms behind several medically-relevant biological activities exhibited by the natural products...
January 4, 2018: Natural Product Reports
Wen-Ju Bai, Xiqing Wang
Covering: 2012 to June 2017This review aims to show that complex natural product synthesis can be streamlined by taking advantage of molecular symmetry. Various strategies to construct molecules with either evident or hidden symmetry are illustrated. Insights regarding the origins and adjustments of these strategies as well as inspiring new methodological developments are deliberated. When a symmetric strategy fails, the corresponding reason is analysed and an alternative approach is briefly provided. Finally, the importance of exploiting molecular symmetry and future research directions are discussed...
December 13, 2017: Natural Product Reports
Michael N Clifford, Indu B Jaganath, Iziar A Ludwig, Alan Crozier
Covering: 2000 up to late 2017This review is focussed upon the acyl-quinic acids, the most studied group within the ca. 400 chlorogenic acids so far reported. The acyl-quinic acids, the first of which was characterised in 1846, are a diverse group of plant-derived compounds produced principally through esterification of an hydroxycinnamic acid and 1l-(-)-quinic acid. Topics addressed in this review include the confusing nomenclature, quantification and characterisation by NMR and MS, biosynthesis and role in planta, and the occurrence of acyl-quinic acids in coffee, their transformation during roasting and delivery to the beverage...
December 13, 2017: Natural Product Reports
Walaa K Mousa, Bilal Athar, Nishanth J Merwin, Nathan A Magarvey
Covering: 2000 to 2017Decades of research on human microbiota have revealed much of their taxonomic diversity and established their direct link to health and disease. However, the breadth of bioactive natural products secreted by our microbial partners remains unknown. Of particular interest are antibiotics produced by our microbiota to ward off invasive pathogens. Members of the human microbiota exclusively produce evolved small molecules with selective antimicrobial activity against human pathogens. Herein, we expand upon the current knowledge concerning antibiotics derived from human microbiota and their distribution across body sites...
November 15, 2017: Natural Product Reports
Roberto G S Berlinck, Ariane F Bertonha, Mirelle Takaki, Julie P G Rodriguez
Covering: 2015 and 2016The chemistry and biology of natural guanidines isolated from microbial culture media, from marine invertebrates, as well as from terrestrial plants and animals, are reviewed. Emphasis is directed to the biosynthesis, total synthesis, ecological roles as well as on the evolution of guanidines isolated from natural sources.
November 15, 2017: Natural Product Reports
Elizabeth Skellam
Covering: up to 2017Cytochalasans are a class of natural products possessing a wide range of important biological activities, yet the full biosynthetic steps towards the formation of their characteristic chemical features remain unknown. This highlight provides an overview of the recent advances made in understanding the biosynthesis of this fascinating class of compounds, complementing and extending a previous comprehensive review of this topic (K. Scherlach, D. Boettger, N. Remme and C. Hertweck, Nat. Prod...
November 15, 2017: Natural Product Reports
Lewis J Dean, Michèle R Prinsep
Covering: up to the end of February 2017Nudibranchs have attracted the attention of natural product researchers due to the potential for discovery of bioactive metabolites, in conjunction with the interesting predator-prey chemical ecological interactions that are present. This review covers the literature published on natural products isolated from nudibranchs up to February 2017 with species arranged taxonomically. Selected examples of metabolites obtained from nudibranchs across the full range of taxa are discussed, including their origins (dietary or biosynthetic) if known and biological activity...
November 14, 2017: Natural Product Reports
Robert A Hill, Andrew Sutherland
A personal selection of 32 recent papers is presented covering various aspects of current developments in bioorganic chemistry and novel natural products such as tryptorubin A isolated from a Streptomyces species.
November 1, 2017: Natural Product Reports
Robert A Hill, Andrew Sutherland
A personal selection of 32 recent papers is presented covering various aspects of current developments in bioorganic chemistry and novel natural products such as caesalpinflavin A from Caesalpina enneaphylla.
October 18, 2017: Natural Product Reports
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