journal
https://read.qxmd.com/read/38488017/structural-biochemical-and-bioinformatic-analyses-of-nonribosomal-peptide-synthetase-adenylation-domains
#1
REVIEW
Stephanie C Heard, Jaclyn M Winter
Covering: 1997 to July 2023The adenylation reaction has been a subject of scientific intrigue since it was first recognized as essential to many biological processes, including the homeostasis and pathogenicity of some bacteria and the activation of amino acids for protein synthesis in mammals. Several foundational studies on adenylation (A) domains have facilitated an improved understanding of their molecular structures and biochemical properties, in particular work on nonribosomal peptide synthetases (NRPSs)...
March 15, 2024: Natural Product Reports
https://read.qxmd.com/read/38482919/cephalotane-diterpenoids-structural-diversity-biological-activity-biosynthetic-proposal-and-chemical-synthesis
#2
REVIEW
Jin-Xin Zhao, Zhan-Peng Ge, Jian-Min Yue
Covering: up to the end of 2023Cephalotane diterpenoids are a unique class of natural products exclusive to the genus Cephalotaxus , featuring a rigid 7,6,5,6-fused tetracyclic architecture. The study of cephalotanes dates back to the 1970s, when harringtonolide (1), a Cephalotaxus troponoid with a peculiar norditerpenoid carbon skeleton, was first discovered. In recent years, prototype C20 diterpenoids proposed as cephalotane were disclosed, which triggered intense studies on this diterpenoid family. To date, a cumulative total of 105 cephalotane diterpenoids with great structural diversity and biological importance have been isolated...
March 14, 2024: Natural Product Reports
https://read.qxmd.com/read/38465694/-bacillus-subtilis-as-a-host-for-natural-product-discovery-and-engineering-of-biosynthetic-gene-clusters
#3
REVIEW
Hanne Put, Hans Gerstmans, Hanne Vande Capelle, Maarten Fauvart, Jan Michiels, Joleen Masschelein
Covering: up to October 2023Many bioactive natural products are synthesized by microorganisms that are either difficult or impossible to cultivate under laboratory conditions, or that produce only small amounts of the desired compound. By transferring biosynthetic gene clusters (BGCs) into alternative host organisms that are more easily cultured and engineered, larger quantities can be obtained and new analogues with potentially improved biological activity or other desirable properties can be generated. Moreover, expression of cryptic BGCs in a suitable host can facilitate the identification and characterization of novel natural products...
March 11, 2024: Natural Product Reports
https://read.qxmd.com/read/38456472/gold-catalyzed-cyclization-and-cycloaddition-in-natural-product-synthesis
#4
REVIEW
Boxu Lin, Tianran Liu, Tuoping Luo
Covering: 2016 to mid 2023Transition metal catalysis, known for its remarkable capacity to expedite the assembly of molecular complexity from readily available starting materials in a single operation, occupies a central position in contemporary chemical synthesis. Within this landscape, gold-catalyzed reactions present a novel and versatile paradigm, offering robust frameworks for accessing diverse structural motifs. In this review, we highlighted a curated selection of publications in the past 8 years, focusing on the deployment of homogeneous gold catalysis in the ring-forming step for the total synthesis of natural products...
March 8, 2024: Natural Product Reports
https://read.qxmd.com/read/38450550/recent-advances-in-the-total-synthesis-of-galantamine-a-natural-medicine-for-alzheimer-s-disease
#5
REVIEW
Bichu Cheng, Qi Wang, Yi An, Fener Chen
Covering: 2006 to 2023(-)-Galantamine is a natural product with distinctive structural features and potent inhibitory activity against acetylcholine esterase (AChE). It is clinically approved for the treatment of Alzheimer's disease. The clinical significance and scarcity of this natural product have prompted extensive and ongoing efforts towards the chemical synthesis of this challenging tetracyclic structure. The objective of this review is to summarize and discuss recent progress in the total synthesis of galantamine from 2006 to 2023...
March 7, 2024: Natural Product Reports
https://read.qxmd.com/read/38411572/plant-peptides-redefining-an-area-of-ribosomally-synthesized-and-post-translationally-modified-peptides
#6
REVIEW
Jonathan R Chekan, Lisa S Mydy, Michael A Pasquale, Roland D Kersten
Covering 1965 to February 2024Plants are prolific peptide chemists and are known to make thousands of different peptidic molecules. These peptides vary dramatically in their size, chemistry, and bioactivity. Despite their differences, all plant peptides to date are biosynthesized as ribosomally synthesized and post-translationally modified peptides (RiPPs). Decades of research in plant RiPP biosynthesis have extended the definition and scope of RiPPs from microbial sources, establishing paradigms and discovering new families of biosynthetic enzymes...
February 27, 2024: Natural Product Reports
https://read.qxmd.com/read/38411278/opportunities-and-challenges-of-ripp-based-therapeutics
#7
REVIEW
Isabel P-M Pfeiffer, Maria-Paula Schröder, Silja Mordhorst
Covering: up to 2024Ribosomally synthesised and post-translationally modified peptides (RiPPs) comprise a substantial group of peptide natural products exhibiting noteworthy bioactivities ranging from antiinfective to anticancer and analgesic effects. Furthermore, RiPP biosynthetic pathways represent promising production routes for complex peptide drugs, and the RiPP technology is well-suited for peptide engineering to produce derivatives with specific functions. Thus, RiPP natural products possess features that render them potentially ideal candidates for drug discovery and development...
February 27, 2024: Natural Product Reports
https://read.qxmd.com/read/38411238/the-insect-microbiome-is-a-vast-source-of-bioactive-small-molecules
#8
REVIEW
Carlismari Oliveira Grundmann, Juan Guzman, Andreas Vilcinskas, Mônica Tallarico Pupo
Covering: September 1964 to June 2023Bacteria and fungi living in symbiosis with insects have been studied over the last sixty years and found to be important sources of bioactive natural products. Not only classic producers of secondary metabolites such as Streptomyces and other members of the phylum Actinobacteria but also numerous bacteria from the phyla Proteobacteria and Firmicutes and an impressive array of fungi (usually pathogenic) serve as the source of a structurally diverse number of small molecules with important biological activities including antimicrobial, cytotoxic, antiparasitic and specific enzyme inhibitors...
February 27, 2024: Natural Product Reports
https://read.qxmd.com/read/38390645/recent-advances-in-discovery-and-biosynthesis-of-natural-products-from-myxobacteria-an-overview-from-2017-to-2023
#9
REVIEW
Chao-Yi Wang, Jia-Qi Hu, De-Gao Wang, Yue-Zhong Li, Changsheng Wu
Covering: 2017.01 to 2023.11Natural products biosynthesized by myxobacteria are appealing due to their sophisticated chemical skeletons, remarkable biological activities, and intriguing biosynthetic enzymology. This review aims to systematically summarize the advances in the discovery methods, new structures, and bioactivities of myxobacterial NPs reported in the period of 2017-2023. In addition, the peculiar biosynthetic pathways of several structural families are also highlighted.
February 23, 2024: Natural Product Reports
https://read.qxmd.com/read/38351834/connecting-metabolome-and-phenotype-recent-advances-in-functional-metabolomics-tools-for-the-identification-of-bioactive-natural-products
#10
REVIEW
Giovanni Andrea Vitale, Christian Geibel, Vidit Minda, Mingxun Wang, Allegra T Aron, Daniel Petras
Covering: 1995 to 2023Advances in bioanalytical methods, particularly mass spectrometry, have provided valuable molecular insights into the mechanisms of life. Non-targeted metabolomics aims to detect and (relatively) quantify all observable small molecules present in a biological system. By comparing small molecule abundances between different conditions or timepoints in a biological system, researchers can generate new hypotheses and begin to understand causes of observed phenotypes. Functional metabolomics aims to investigate the functional roles of metabolites at the scale of the metabolome...
February 14, 2024: Natural Product Reports
https://read.qxmd.com/read/38323463/specialized-metabolite-modifications-in-brassicaceae-seeds-and-plants-diversity-functions-and-related-enzymes
#11
REVIEW
Léa Barreda, Céline Brosse, Stéphanie Boutet, François Perreau, Loïc Rajjou, Loïc Lepiniec, Massimiliano Corso
Covering: up to 2023Specialized metabolite (SM) modifications and/or decorations, corresponding to the addition or removal of functional groups ( e.g. hydroxyl, methyl, glycosyl or acyl group) to SM structures, contribute to the huge diversity of structures, activities and functions of seed and plant SMs. This review summarizes available knowledge (up to 2023) on SM modifications in Brassicaceae and their contribution to SM plasticity. We give a comprehensive overview on enzymes involved in the addition or removal of these functional groups...
February 7, 2024: Natural Product Reports
https://read.qxmd.com/read/38318713/hot-off-the-press
#12
REVIEW
Robert A Hill, Andrew Sutherland
A personal selection of 32 recent papers is presented covering various aspects of current developments in bioorganic chemistry and novel natural products such as dcalycinumine A from Daphniphyllum calycinum .
February 6, 2024: Natural Product Reports
https://read.qxmd.com/read/38294038/the-kornblum-delamare-rearrangement-in-natural-product-synthesis-25-years-of-innovation
#13
REVIEW
Marc C Kimber, Darren S Lee
Covering: 1998 up to the end of 2023Since its initial disclosure in 1951, the Kornblum DeLaMare rearrangement has proved an important synthetic transformation and has been widely adopted as a biomimetic step in natural product synthesis. Utilising the base catalysed decomposition of alkyl peroxides to yield a ketone and alcohol has found use in many syntheses as well as a key strategic step, including the unmasking of furans, as a biomimetic synthetic tool, and the use of the rearrangement to install oxygen enantioselectively...
January 31, 2024: Natural Product Reports
https://read.qxmd.com/read/38291905/controllable-skeletal-reorganizations-in-natural-product-synthesis
#14
REVIEW
Zeliang Zhang, Xiao Qian, Yucheng Gu, Jinghan Gui
Covering: 2016 to 2023The synthetic chemistry community is always in pursuit of efficient routes to natural products. Among the many available general strategies, skeletal reorganization, which involves the formation, cleavage, and migration of C-C and C-heteroatom bonds, stands out as a particularly useful approach for the efficient assembly of molecular skeletons. In addition, it allows for late-stage modification of natural products for quick access to other family members or unnatural derivatives. This review summarizes efficient syntheses of steroid, terpenoid, and alkaloid natural products that have been achieved by means of this strategy in the past eight years...
January 31, 2024: Natural Product Reports
https://read.qxmd.com/read/38284321/bacterial-polyynes-uncovered-a-journey-through-their-bioactive-properties-biosynthetic-mechanisms-and-sustainable-production-strategies
#15
REVIEW
Wei-Chih Chin, Yang-Zhi Zhou, Hao-Yung Wang, Yu-Ting Feng, Ru-Yin Yang, Zih-Fang Huang, Yu-Liang Yang
Covering: up to 2023Conjugated polyynes are natural compounds characterized by alternating single and triple carbon-carbon bonds, endowing them with distinct physicochemical traits and a range of biological activities. While traditionally sourced mainly from plants, recent investigations have revealed many compounds originating from bacterial strains. This review synthesizes current research on bacterial-derived conjugated polyynes, delving into their biosynthetic routes, underscoring the variety in their molecular structures, and examining their potential applications in biotechnology...
January 29, 2024: Natural Product Reports
https://read.qxmd.com/read/38275179/vallesamidine-and-schizozygane-alkaloids-rearranged-monoterpene-indole-alkaloids-and-synthetic-endeavours
#16
REVIEW
Xiangyu Zhang
Covering 1963 to 2023Monoterpene indole alkaloids are the main sub-family of indole alkaloids with fascinating structures, stereochemistry, and diverse bioactivities ( e.g. , anticancer, anti-malarial and anti-arrhythmic etc. ). Vallesamidine alkaloids and structurally more complex schizozygane alkaloids are small groups of rearranged monoterpene indole alkaloids with a unique 2,2,3-trialkylated indoline scaffold, while schizozygane alkaloids can generate a further rearranged skeleton, isoschizozygane, possessing a tetra-substituted, bridged tetrahydroquinoline core...
January 26, 2024: Natural Product Reports
https://read.qxmd.com/read/38265076/biosynthesis-of-fungal-terpenoids
#17
REVIEW
Pan Luo, Jia-Hua Huang, Jian-Ming Lv, Gao-Qian Wang, Dan Hu, Hao Gao
Covering: up to August 2023Terpenoids, which are widely distributed in animals, plants, and microorganisms, are a large group of natural products with diverse structures and various biological activities. They have made great contributions to human health as therapeutic agents, such as the anti-cancer drug paclitaxel and anti-malarial agent artemisinin. Accordingly, the biosynthesis of this important class of natural products has been extensively studied, which generally involves two major steps: hydrocarbon skeleton construction by terpenoid cyclases and skeleton modification by tailoring enzymes...
January 24, 2024: Natural Product Reports
https://read.qxmd.com/read/38259139/promoter-engineering-of-natural-product-biosynthetic-gene-clusters-in-actinomycetes-concepts-and-applications
#18
REVIEW
Chang-Hun Ji, Hyun-Woo Je, Hiyoung Kim, Hahk-Soo Kang
Covering 2011 to 2022Low titers of natural products in laboratory culture or fermentation conditions have been one of the challenging issues in natural products research. Many natural product biosynthetic gene clusters (BGCs) are also transcriptionally silent in laboratory culture conditions, making it challenging to characterize the structures and activities of their metabolites. Promoter engineering offers a potential solution to this problem by providing tools for transcriptional activation or optimization of biosynthetic genes...
January 23, 2024: Natural Product Reports
https://read.qxmd.com/read/38230759/correction-future-antimalarials-from-artemisia-a-rationale-for-natural-product-mining-against-drug-refractory-plasmodium-stages
#19
Alexandre Maciuk, Dominique Mazier, Romain Duval
Correction for 'Future antimalarials from Artemisia ? A rationale for natural product mining against drug-refractory Plasmodium stages' by Alexandre Maciuk et al. , Nat. Prod. Rep. , 2023, 40 , 1130-1144, https://doi.org/10.1039/D3NP00001J.
January 17, 2024: Natural Product Reports
https://read.qxmd.com/read/38197414/purine-nucleoside-antibiotics-recent-synthetic-advances-harnessing-chemistry-and-biology
#20
REVIEW
Jonas Motter, Caecilie M M Benckendorff, Sarah Westarp, Peter Sunde-Brown, Peter Neubauer, Anke Kurreck, Gavin J Miller
Covering: 2019 to 2023Nucleoside analogues represent one of the most important classes of small molecule pharmaceuticals and their therapeutic development is successfully established within oncology and for the treatment of viral infections. However, there are currently no nucleoside analogues in clinical use for the management of bacterial infections. Despite this, a significant number of clinically recognised nucleoside analogues are known to possess some antibiotic activity, thereby establishing a potential source for new therapeutic discovery in this area...
January 10, 2024: Natural Product Reports
journal
journal
28978
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.