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Natural Product Reports

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https://www.readbyqxmd.com/read/27907217/natural-products-from-myxobacteria-novel-metabolites-and-bioactivities
#1
REVIEW
J Herrmann, A Abou Fayad, R Müller
Covering: 2011-July 2016Myxobacteria are a rich source for structurally diverse secondary metabolites with intriguing biological activities. Here we report on new natural products that were isolated from myxobacteria in the period of 2011 to July 2016. Some examples of recent advances on modes-of-action are also summarised along with a more detailed overview on five compound classes currently assessed in preclinical studies.
December 1, 2016: Natural Product Reports
https://www.readbyqxmd.com/read/27874907/natural-products-as-mediators-of-disease
#2
REVIEW
Neha Garg, Tal Luzzatto-Knaan, Alexey V Melnik, Andrés Mauricio Caraballo-Rodríguez, Dimitrios J Floros, Daniel Petras, Rachel Gregor, Pieter C Dorrestein, Vanessa V Phelan
Covering: up to 2016Humans are walking microbial ecosystems, each harboring a complex microbiome with the genetic potential to produce a vast array of natural products. Recent sequencing data suggest that our microbial inhabitants are critical for maintaining overall health. Shifts in microbial communities have been correlated to a number of diseases including infections, inflammation, cancer, and neurological disorders. Some of these clinically and diagnostically relevant phenotypes are a result of the presence of small molecules, yet we know remarkably little about their contributions to the health of individuals...
November 22, 2016: Natural Product Reports
https://www.readbyqxmd.com/read/27813539/triterpenoids
#3
REVIEW
Robert A Hill, Joseph D Connolly
Covering: 2013. Previous review: Nat. Prod. Rep., 2015, 29, 1028-1065This review covers the isolation and structure determination of triterpenoids reported during 2013 including squalene derivatives, lanostanes, holostanes, cycloartanes, cucurbitanes, dammaranes, euphanes, tirucallanes, tetranortriterpenoids, quassinoids, lupanes, oleananes, friedelanes, ursanes, hopanes, serratanes, isomalabaricanes and saponins; 350 references are cited.
November 4, 2016: Natural Product Reports
https://www.readbyqxmd.com/read/27785514/hot-off-the-press
#4
Robert A Hill, Andrew Sutherland
A personal selection of 32 recent papers is presented covering various aspects of current developments in bioorganic chemistry and novel natural products such as kanamienamide from the marine cyanobacterium Moorea bouillonii.
October 27, 2016: Natural Product Reports
https://www.readbyqxmd.com/read/27782262/pyrrolizidine-alkaloids-occurrence-biology-and-chemical-synthesis
#5
REVIEW
Jeremy Robertson, Kiri Stevens
Covering: 2013 up to the end of 2015This review covers the isolation and structure of new pyrrolizidines; pyrrolizidine biosynthesis; biological activity, including the occurrence of pyrrolizidines as toxic components or contaminants in foods and beverages; and formal and total syntheses of naturally-occurring pyrrolizidine alkaloids and closely related non-natural analogues.
October 26, 2016: Natural Product Reports
https://www.readbyqxmd.com/read/27759131/pyranonaphthoquinones-isolation-biology-and-synthesis-an-update
#6
Briar J Naysmith, Paul A Hume, Jonathan Sperry, Margaret A Brimble
Covering: 2008 to 2015. A review on the isolation, biological activity and synthesis of pyranonaphthoquinone natural products from 2008-2015 is providedThis review discusses the isolation, biological activity and synthesis of pyranonaphthoquinone natural products, covering the years 2008-2015. The pyranonaphthoquinones are a group of metabolites sharing a common naphtho[2,3-c]pyran-5,10-dione ring system that have been isolated from a wide range of microorganisms, plants and insects. In addition to their synthetically challenging molecular structures, pyranonaphthoquinones exhibit a wide array of biological activity, including anti-bacterial, anti-fungal and anti-cancer properties...
October 19, 2016: Natural Product Reports
https://www.readbyqxmd.com/read/27722705/phytocannabinoids-a-unified-critical-inventory
#7
Lumír Ondřej Hanuš, Stefan Martin Meyer, Eduardo Muñoz, Orazio Taglialatela-Scafati, Giovanni Appendino
Covering up to January 2016Cannabis sativa L. is a prolific, but not exclusive, producer of a diverse group of isoprenylated resorcinyl polyketides collectively known as phytocannabinoids. The modular nature of the pathways that merge into the phytocannabinoid chemotype translates in differences in the nature of the resorcinyl side-chain and the degree of oligomerization of the isoprenyl residue, making the definition of phytocannabinoid elusive from a structural standpoint. A biogenetic definition is therefore proposed, splitting the phytocannabinoid chemotype into an alkyl- and a β-aralklyl version, and discussing the relationships between phytocannabinoids from different sources (higher plants, liverworts, fungi)...
October 10, 2016: Natural Product Reports
https://www.readbyqxmd.com/read/27714064/amaryllidaceae-and-sceletium-alkaloids
#8
Zhong Jin
Covering: July 2012 to June 2015. Previous review: Nat. Prod. Rep., 2013, 30, 849-868The latest progress on the isolation, identification, biological activity and synthetic studies of the structurally diverse alkaloids from plants of family Amaryllidaceae has been summarized in this review. In addition, the structurally related alkaloids isolated from Sceletium species were discussed as well.
September 23, 2016: Natural Product Reports
https://www.readbyqxmd.com/read/27714041/the-3-4-dioxygenated-5-hydroxy-4-aryl-quinolin-2-1h-one-alkaloids-results-of-20-years-of-research-uncovering-a-new-family-of-natural-products
#9
Sebastian O Simonetti, Enrique L Larghi, Teodoro S Kaufman
Covering: up to April 2016Aspergillus and Penicillium are fungal species known to produce a high diversity of secondary metabolites, many of them endowed with interesting bioactivity. The small but steadily growing family of the naturally occurring 5-hydroxy-4-aryl-quinolin-2(1H)-one alkaloids and closely related compounds, which represent the results of various research projects that spanned over 20 years and involved scientists from different continents, are covered here. Emphasis is placed on the isolation and chemical structures of the different compounds, together with their source microorganisms, environmental conditions, country or region of origin, and relevant biological activities...
September 22, 2016: Natural Product Reports
https://www.readbyqxmd.com/read/27714029/muscarine-imidazole-oxazole-and-thiazole-alkaloids
#10
Zhong Jin
Covering: July 2012 to June 2015. Previous review: Nat. Prod. Rep., 2013, 30, 869-915The structurally diverse imidazole-, oxazole-, and thiazole-containing secondary metabolites are widely distributed in terrestrial and marine environments, and exhibit extensive pharmacological activities. In this review the latest progress involving the isolation, biological activities, and chemical and biogenetic synthesis studies on these natural products has been summarized.
September 16, 2016: Natural Product Reports
https://www.readbyqxmd.com/read/27714078/advances-in-the-synthesis-of-glycosidic-macrolides-clavosolides-a-d-and-cyanolide-a
#11
Kiyoun Lee, Megan L Lanier, Jae-Hwan Kwak, Hyoungsu Kim, Jiyong Hong
Covering: 2005 to 2016Clavosolides A-D and cyanolide A are glycosidic macrolides and represent a new family of marine natural products. They possess a number of unusual structural features and have attracted considerable interest from the synthetic community. This review presents a comprehensive survey of all aspects of the clavosolides A-D and cyanolide A. Specific topics include isolation, structure determination, biological activity, and synthetic approaches.
September 12, 2016: Natural Product Reports
https://www.readbyqxmd.com/read/27604382/comparative-mass-spectrometry-based-metabolomics-strategies-for-the-investigation-of-microbial-secondary-metabolites
#12
REVIEW
Brett C Covington, John A McLean, Brian O Bachmann
Covering: 2000 to 2016The labor-intensive process of microbial natural product discovery is contingent upon identifying discrete secondary metabolites of interest within complex biological extracts, which contain inventories of all extractable small molecules produced by an organism or consortium. Historically, compound isolation prioritization has been driven by observed biological activity and/or relative metabolite abundance and followed by dereplication via accurate mass analysis. Decades of discovery using variants of these methods has generated the natural pharmacopeia but also contributes to recent high rediscovery rates...
September 7, 2016: Natural Product Reports
https://www.readbyqxmd.com/read/27879979/contents-list
#13
(no author information available yet)
No abstract text is available yet for this article.
November 23, 2016: Natural Product Reports
https://www.readbyqxmd.com/read/27879978/back-cover
#14
(no author information available yet)
No abstract text is available yet for this article.
November 23, 2016: Natural Product Reports
https://www.readbyqxmd.com/read/27879977/front-cover
#15
(no author information available yet)
No abstract text is available yet for this article.
November 23, 2016: Natural Product Reports
https://www.readbyqxmd.com/read/27683736/back-cover
#16
(no author information available yet)
No abstract text is available yet for this article.
October 28, 2016: Natural Product Reports
https://www.readbyqxmd.com/read/27683735/contents-list
#17
(no author information available yet)
No abstract text is available yet for this article.
October 28, 2016: Natural Product Reports
https://www.readbyqxmd.com/read/27683734/front-cover
#18
(no author information available yet)
No abstract text is available yet for this article.
October 28, 2016: Natural Product Reports
https://www.readbyqxmd.com/read/27467076/diterpenoids-of-terrestrial-origin
#19
James R Hanson
Covering January to December 2015. Previous review; Nat. Prod. Rep., 2015, 32, 1654-1663.This review covers the isolation and chemistry of diterpenoids from terrestrial as opposed to marine sources and includes labdanes, clerodanes, abietanes, pimaranes, kauranes, cembranes and their cyclization products. There are 214 references.
October 28, 2016: Natural Product Reports
https://www.readbyqxmd.com/read/27433555/clerodane-diterpenes-sources-structures-and-biological-activities
#20
Rongtao Li, Susan L Morris-Natschke, Kuo-Hsiung Lee
Covering: 1990 to 2015The clerodane diterpenoids are a widespread class of secondary metabolites and have been found in several hundreds of plant species from various families and in organisms from other taxonomic groups. These substances have attracted interest in recent years due to their notable biological activities, particularly insect antifeedant properties. In addition, the major active clerodanes of Salvia divinorum can be used as novel opioid receptor probes, allowing greater insight into opioid receptor-mediated phenomena, as well as opening additional areas for chemical investigation...
October 28, 2016: Natural Product Reports
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