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Seminars in Diagnostic Pathology

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https://www.readbyqxmd.com/read/29277280/lymphadenopathies-in-human-immunodeficiency-virus-infection
#1
REVIEW
Carlos Barrionuevo-Cornejo, Daniela Dueñas-Hancco
This article describes the various non-neoplastic lymphadenopathies that occur in patients infected with the human immunodeficiency virus (HIV), before or during the stage of acquired immunodeficiency syndrome (AIDS). The stages that develop during the HIV infection include: primary infection (acute infection, spread of the virus, development of host immune response, and acute retroviral syndrome), chronic infection or clinical latency, and finally, the AIDS stage. Non-neoplastic lymphadenopathies can occur at any of these phases of the infection and are due to multiple causes that can be divided into infectious causes (bacterial, fungal, parasitic, viral), and reactive causes (persistent generalized lymphadenopathy and a variety of situations that they also occur in immunocompetent people such as Castleman's disease and Kikuchi-Fujimoto's disease, among others)...
December 6, 2017: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/29273279/re-defining-reactive-lymphadenopathies-how-molecular-lessons-have-changed-our-minds
#2
EDITORIAL
Alejandro A Gru, Miguel A Piris
No abstract text is available yet for this article.
December 6, 2017: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/29217303/castleman-disease-and-rosai-dorfman-disease
#3
REVIEW
Miguel A Piris, Elena Aguirregoicoa, Santiago Montes-Moreno, Catuxa Celeiro-Muñoz
This chapter describes the main features of two different diseases, Castleman Disease (CD) and Rosai-Dorfman Disease (RDD). Castleman disease (CD) is a clinical and histopathologically heterogeneous lymphoproliferative disorder that encompasses at least three distinct entities with some common overlapping morphological features: Hyaline Vascular CD (HVCD), Unicentric Plasma Cell CD and Multicentric CD. The most important feature of HVCD is the presence of abnormal germinal centers with hyaline-vascular transformation, sometimes showing multiple germinal centers within a single reactive lymphoid follicle, this outlining HVCD as a disorder of follicular dendritic cells...
December 2, 2017: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/29208331/autoimmune-and-medication-induced-lymphadenopathies
#4
REVIEW
Alejandro A Gru, Dennis P O'Malley, Aliso Viejo
This article will provide a discussion of some common autoimmune disorders that could affect the lymph nodes and potentially mimic B and T-cell lymphomas. Some of these disorders are more characteristic of individuals in the pediatric age group (autoimmune lymphoproliferative syndrome, Kawasaki disease), while others present in older individuals (rheumatoid arthritis, lupus erythematosus, sarcoidosis). A common finding that groups all of these disorders together is the overall relative preservation of the architecture, a feature that can be particularly helpful to distinguish them from many B and T-cell lymphomas...
November 28, 2017: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/29203116/diagnosis-and-management-of-metastatic-neoplasms-with-unknown-primary
#5
REVIEW
Tilmann Bochtler, Harald Löffler, Alwin Krämer
In cancer of unknown primary (CUP), metastases are clinically and histologically confirmed, but the primary tumor site remains elusive after extensive work-up. CUPs make up for 2-3% of all epithelial malignancies. The two prevailing histologies are adenocarcinomas and undifferentiated carcinomas, whereas squamous cell carcinomas, neuroendocrine carcinomas and rare histologies account for the remaining 10%. The diagnostic work-up in CUP relies strongly on a detailed immunohistological (IHC) analysis in order to characterize the tumor type, nowadays aided by molecular techniques...
November 26, 2017: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/29198586/metastases-of-malignant-neoplasms-historical-biological-clinical-considerations
#6
REVIEW
Mark R Wick
The metastasis of neoplastic cells from their site of origin to distant anatomic locations continues to be the principal cause of death from malignant tumors, and that fact has been recognized by physicians for over a century. After the work done by Halsted in the treatment of breast cancer in the 1880s, accepted surgical canon held that metastasis occurred in a linear fashion, with centrifugal "growth in continuity" from the primary neoplasm that first involved regional lymph nodes. Those structures were considered to then be the sources of more distant, visceral metastases...
November 24, 2017: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/29224972/immunohistochemistry-carcinomas-of-unknown-primary-and-incidence-rates
#7
REVIEW
Edward B Stelow, Hadi Yaziji
Pathologists use immunohistochemistry is their day-to-day practices to assist in distinguishing site of origin of metastatic carcinomas. Here, the work-up is discussed neuroendocrine carcinomas, squamous cell carcinomas and adenocarcinomas with particular attention to tumor incident rates and predictive values of the best-performing immunohistochemical markers.
November 23, 2017: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/29198813/preface
#8
EDITORIAL
Mark R Wick
No abstract text is available yet for this article.
November 22, 2017: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/29248205/a-guided-tour-of-selected-issues-pertaining-to-metastatic-carcinomas-involving-or-originating-from-the-gynecologic-tract
#9
REVIEW
Robert A Soslow, Rajmohan Murali
No abstract text is available yet for this article.
November 20, 2017: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/29174934/primary-lesions-that-may-imitate-metastatic-tumors-histologically-a-selective-review
#10
REVIEW
Mark R Wick
Several primary pathologic entities in diverse anatomic locations have the potential to simulate metastatic neoplasms histologically. Their misinterpretation as such may result in needless and extensive clinical evaluations that are intended to detect a presumed malignancy at another site. More importantly, mistakes of this type can deprive patients of surgical excisions that could be curative. This presentation considers a review of selected primary lesions that can simulate metastases. They include hemangioblastoma, glioblastoma and meningioma with epithelial metaplasia, choroid plexus carcinomas, primary neuroendocrine carcinomas in unusual locations, special forms of sinonasal and salivary glandular adenocarcinoma, clear-cell thyroid carcinomas, unusual microscopic subtypes of pulmonary adenocarcinoma, epithelioid myomelanocytomas ("sugar tumors"), mesotheliomas, primary thymic carcinomas, endodermal choristomas of the interatrial myocardium, peripheral cholangiocarcinoma, adrenocortical carcinoma, adenocarcinomas of the urinary bladder, mucinous and "rhabdoid" tumors of the ovaries, rete testis adenocarcinomas, interdigitating dendritic-cell sarcoma of lymph nodes, selected sweat gland carcinomas, cutaneous Merkel cell carcinoma, primary dermal and subcutaneous melanoma, mucosal and visceral melanomas, epithelioid sarcoma, clear-cell sarcoma, and adamantinoma of long bones...
November 17, 2017: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/29174933/surviving-at-a-distant-site-the-organotropism-of-metastatic-breast-cancer
#11
REVIEW
Shi Wei, Gene P Siegal
Many cancers demonstrate a non-random distribution of sites for distant relapse while others have the propensity to metastasize to multiple organ systems. One of the notable recent findings is that the breast cancer subtypes differ not only in their biological characteristics as primary tumors but also in their capacity for metastatic progression. This information could potentially be utilized in treatment decision making and surveillance strategies.
November 16, 2017: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/29174725/epstein-barr-virus-ebv-associated-reactive-and-indeterminate-lymphoid-proliferations-in-the-lymph-node
#12
REVIEW
Nadine Aguilera, Aaron Auerbach
No abstract text is available yet for this article.
November 15, 2017: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/29173940/lymph-node-stromal-and-vascular-proliferations
#13
REVIEW
Mina L Xu, Dennis O'Malley
The recognition and reporting of stromal and vascular lesions of the lymph node is rife with difficulties including relative rarity, a lack of familiarity with lesions and the challenges of using ancillary studies appropriately. In this manuscript, we highlight a range of benign stromal and vascular abnormalities that can be identified in nodal specimens.
November 15, 2017: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/29157939/lymphadenopathy-associated-with-igg4-related-disease-diagnosis-differential-diagnosis
#14
REVIEW
Mark R Wick, Dennis P O'Malley
IgG4-related sclerosing disease, which now encompasses diverse organ-related disorders with various prior eponymic designations, may also present with solitary or multifocal lymph node enlargement. This review considers the histopathologic features of IgG4 lymphadenopathy (IgG4LAD), which has been subdivided by Cheuk & Chan into 5 microscopic subtypes. Those include variants that are typified by multicentric Castleman disease (MCD)-like changes, follicular hyperplasia, interfollicular lymphoplasmacytic proliferation, progressive transformation of germinal centers, and formation of inflammatory pseudotumor (IPT)-like lesions...
November 11, 2017: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/29129357/in-situ-neoplasia-in-lymph-node-pathology
#15
REVIEW
Naoki Oishi, Santiago Montes-Moreno, Andrew L Feldman
In situ neoplasia represents the earliest form of malignant progression and is characterized by localization limited to the compartment corresponding to the cell of origin. Like other cancers, lymphoid neoplasms are considered to develop by multistep pathogenetic mechanisms. However, because of the circulating nature of lymphocytes, in situ lymphoid neoplasia may be difficult to identify histopathologically, and the compartment to which it is restricted may be physiological rather than strictly anatomical. The 2016 WHO classification of lymphoid neoplasms recognizes two in situ entities: in situ follicular neoplasia (ISFN) and in situ mantle cell neoplasia (ISMCN)...
November 9, 2017: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/29150219/non-neoplastic-histiocytic-and-dendritic-cell-disorders-in-lymph-nodes
#16
REVIEW
Caoimhe Egan, Elaine S Jaffe
Benign and malignant proliferations of histiocytes and dendritic cells may be encountered in lymph nodes. Reactive histiocytic and dendritic cell infiltrates occur in response to diverse stimuli and in addition to causing lymphadenopathy, may be present unexpectedly in lymph nodes excised for other indications. This review summarizes the pathogenesis and histopathological features of the various non-neoplastic histiocytic and dendritic cell infiltrates that can occur in lymph nodes.
November 3, 2017: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/28693908/pathology-of-pulmonary-tuberculosis-and-non-tuberculous-mycobacterial-lung-disease-facts-misconceptions-and-practical-tips-for-pathologists
#17
REVIEW
Deepali Jain, Subha Ghosh, Lucileia Teixeira, Sanjay Mukhopadhyay
Most pathologists are familiar with the microscopic features of tuberculosis and the need to examine special stains for acid-fast bacteria (AFB) in cases of granulomatous lung disease. However, misconceptions do exist, including the concept that finding AFB in "caseating granulomas" confirms the diagnosis of tuberculosis. This dogma is attributable to the high prevalence of tuberculosis in many countries, as well as unfamiliarity with the microscopic spectrum of non-tuberculous mycobacterial lung disease. This review aims to provide surgical pathologists with practical tips to identify AFB, illustrate the histologic overlap between pulmonary tuberculosis and non-tuberculous mycobacterial lung disease, and highlight the importance of cultures in this setting...
November 2017: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/29110897/iatrogenic-lesions-of-soft-tissue-and-bone
#18
REVIEW
S M O'Connor, S E Wobker, D M Cardona, W Eward, R J Esther, L G Dodd
No abstract text is available yet for this article.
September 28, 2017: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/29066044/iatrogenic-solid-tumors-following-immunosuppressive-therapy
#19
REVIEW
Kossivi Dantey, Liron Pantanowitz
Immunosuppression induced by chronic medication, such as occurs post-transplantation, may increase a patient's risk of developing solid tumors. These are often rare tumors characterized by odd presentations. This review focuses on commonly encountered iatrogenic, non-hematopoietic solid tumors following immunotherapy and provides a practical approach to their diagnosis. All of the malignancies covered in this review are viral-induced. They include human papillomavirus (HPV)-associated carcinomas, Epstein-Barr virus (EBV)-associated tumors, Merkel cell polyomavirus (MCPyV)-related Merkel cell carcinoma, and Human Herpesvirus 8 (HHV8)-related Kaposi sarcoma...
September 20, 2017: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/28964593/iatrogenically-false-positive-sentinel-lymph-nodes-in-breast-cancer-methods-of-recognition-and-evaluation
#20
REVIEW
Anupma Nayak, Ira J Bleiweiss
With the introduction of sentinel lymph node (SLN) biopsy as a standard procedure for staging clinically node negative breast cancer patients, meticulous pathologic evaluation of SLNs by serial sections and/or immunohistochemistry for cytokeratins has become commonplace in order to detect small volume metastases (isolated tumor cells and micrometastases). This practice has also brought to the fore the concept of iatrogenically false positive sentinel nodes secondary to epithelial displacement produced largely by preoperative needling procedures...
September 20, 2017: Seminars in Diagnostic Pathology
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