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Seminars in Diagnostic Pathology

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https://www.readbyqxmd.com/read/28024703/a-new-molecular-paradigm-in-mycosis-fungoides-and-s%C3%A3-zary-syndrome
#1
Kojo S J Elenitoba-Johnson, Ryan Wilcox
Mycosis Fungoides (MF) and Sézary Syndrome (SS) are clonal proliferations of mature T-cells manifesting as lymphoproliferative disorders in which the neoplastic cells show a strong propensity for skin-homing. While the predominant site of presentation in MF is the skin, the peripheral blood carries a significant tumor burden in Sézary Syndrome such that it resembles a "leukemic" disease. While the genetic basis of these diseases has been studied using different approaches in the previous years, recent genome-wide studies employing massively parallel sequencing techniques now offer new insights into the molecular pathogenesis of these diseases...
December 7, 2016: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/27988064/cutaneous-ebv-related-lymphoproliferative-disorders
#2
Alejandro A Gru, Elaine S Jaffe
This article will focus on the cutaneous lymphoproliferative disorders associated with EBV, with an emphasis on the upcoming changes in the revised 4th Edition of the WHO classification of tumors of the hematopoietic system, many of which deal with cutaneous disorders derived from NK-cells or T-cells. Extranodal NK/T-cell lymphoma usually presents in the upper aerodigestive tract, but can involve the skin secondarily. EBV-associated T- and NK-cell lymphoproliferative disorders (LPD) in the pediatric age group include the systemic diseases, chronic active EBV infection (CAEBV) and systemic EBV+ T-cell lymphoma of childhood...
December 7, 2016: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/28065463/primary-cutaneous-b-cell-lymphomas-with-large-cell-predominance-primary-cutaneous-follicle-center-lymphoma-diffuse-large-b-cell-lymphoma-leg-type-and-intravascular-large-b-cell-lymphoma
#3
Charity B Hope, Laura B Pincus
In this review, we present clinical features and detailed histopathologic, immunologic, and molecular information regarding primary cutaneous follicle center lymphoma and primary cutaneous diffuse large B-cell lymphoma, leg type which together represent two of the three most common types of primary cutaneous B-cell lymphoma recognized in the current WHO classification system.(1,2) Overall, B-cell lymphomas represent 19-27% of primary cutaneous lymphomas in most large European and American studies(3-6) and together, primary cutaneous follicle center lymphoma and primary cutaneous diffuse large B-cell lymphoma, leg type account for approximately 2/3 to ¾ of these cases...
December 2, 2016: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/27989527/the-landscape-of-cutaneous-lymphomas-in-2016-an-introduction
#4
EDITORIAL
Alejandro A Gru, Elaine S Jaffe
No abstract text is available yet for this article.
December 2, 2016: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/27993440/a-new-era-for-cutaneous-cd30-positive-t-cell-lymphoproliferative-disorders
#5
Werner Kempf
Cutaneous CD30+ T-cell lymphoproliferative disorders (CD30+ T-LPD) represent a spectrum encompassing lymphomatoid papulosis (LyP), primary cutaneous anaplastic large-cell lymphoma (pcALCL) and borderline lesions. They share the expression of CD30 as a common phenotypic marker. They differ however in their clinical presentation, the histological features and clinical course. Moreover, LyP and PcALCL show numerous clinical, histological and phenotypic variants. Overlapping features of LyP and pcALCL with themselves and with other cutaneous and systemic lymphomas emphasize the importance of careful clinicopathologic correlation and staging in the diagnosis of CD30+ T-LPD...
November 29, 2016: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/27986434/cutaneous-marginal-zone-lymphomas
#6
Steven H Swerdlow
Primary cutaneous marginal zone lymphoma (CMZL) is one of the major primary B-cell lymphomas of skin. Two types are recognized: a more common class-chain switched CMZL, and a much less common IgM+ CMZL. The extremely indolent course, together with other features distinct from most other MALT lymphomas, has led some to question whether at least the class-switched cases should be considered an overt lymphoma.
November 29, 2016: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/27986433/cutaneous-lymphomas-with-a-panniculitic-presentation
#7
Rein Willemze
Subcutaneous panniculitis-like T-cell lymphoma and primary cutaneous gamma/delta T-cell lymphoma are the two most common types of cutaneous T-cell lymphoma presenting with panniculitis-like lesions. In this article the characteristic clinical, histological and immunophenotypical features of these conditions are reviewed and criteria to differentiate these tumors from other benign and malignant lymphoproliferations presenting with panniculitis-like lesions are discussed.
November 29, 2016: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/27979335/non-lymphoid-lesions-that-may-mimic-cutaneous-hematopoietic-neoplasms-histologically
#8
Mark R Wick, Daniel J Santa Cruz, Alejandro A Gru
This review considers neoplastic lesions that originate in the skin, and which have the potential to imitate hematopoietic proliferations at a histological level. They include lymphoepithelioma-like carcinoma, Merkel cell carcinoma, benign lymphadenoma, pseudolymphomatous angiosarcoma, lymphadenoid dermatofibroma, lymphomatoid atypical fibroxanthoma, histiocytoid (epithelioid) hemangioma, and inflamed melanocytic lesions. The clinical and pathological features of those tumors are considered.
November 29, 2016: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/27979336/past-present-and-future-of-cutaneous-lymphomas
#9
Lorenzo Cerroni
Primary cutaneous lymphomas represent a broad group of diseases with different clinical, histopathological, phenotypic, molecular, and prognostic features. All cutaneous lymphomas share the same tropism of neoplastic lymphocytes for the skin, but precise classification is paramount for proper management of the patients. Primary cutaneous lymphomas are classified according to the schemes proposed by the European Organization for Research and Treatment of Cancer (EORTC)-Cutaneous Lymphomas Task Force together with the World Health Organization (WHO) in 2005, and the WHO classification of 2008 with the 2016 update...
November 28, 2016: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/27863559/erratum-to-introduction-seminars-in-diagnostic-pathology-33-5-2016-243
#10
Mark R Wick
No abstract text is available yet for this article.
November 2016: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/27751600/pediatric-soft-tissue-tumor-pathology-a-happy-morpho-molecular-union
#11
Maureen O'Sullivan
Since its foundation by remarkably talented and insightful individuals, prominently including Pepper Dehner, pediatric soft tissue tumor pathology has developed at an immense rate. The morphologic classification of tumoral entities has extensively been corroborated, but has also evolved with refinement or realignment of these classifications, through accruing molecular data, with many derivative ancillary diagnostic assays now already well-established. Tumors of unclear histogenesis, classically morphologically undifferentiated, are prominent amongst pediatric sarcomas, however, the classes of undifferentiated round- or spindle-cell-tumors-not-otherwise-specified are being dismantled gradually with the identification of their molecular underpinnings...
November 2016: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/27720561/histiocytic-proliferations
#12
Sarangarajan Ranganathan
The study of Histiocytic lesions has been a passion of Pepper Dehner over the years. He has contributed several case series and reviews on various categories of these diseases for over 4 decades, with his earliest articles in the 1970s. He has written on all aspects of the disease including seminal articles on Langerhans cell histiocytosis (LCH) and their prognostic features, his experiences with regressing atypical histiocytosis, his encounters with malignant histiocytosis, and classic articles on juvenile xanthogranuloma...
November 2016: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/27838088/pulmonary-and-pleural-pathology-contributions-of-dr-louis-pepper-dehner
#13
Jon H Ritter, D Ashley Hill
Dr. Louis Dehner is an internationally renowned surgical pathologist who has published multiple textbooks and has authored or co-authored nearly 400 original articles in the medical literature. While many think of him as a pediatric pathologist, he has contributed to the literature across virtually the entire breadth of surgical pathology, and the lung and pleura is no exception. This review will highlight Dr. Dehner׳s contributions to the pulmonary and pleural pathology literature in the areas of infectious disease, medical lung disease and transplant pathology, and a number of neoplasms of the lung and pleura, with the remainder of this manuscript dedicated to the still evolving story of the pleuropulmonary blastoma as the signature contribution of his long and distinguished career...
September 21, 2016: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/27726995/testicular-germ-cell-tumors-tgcts-in-neonates-and-infants
#14
Juan Carlos Manivel
No abstract text is available yet for this article.
September 6, 2016: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/27720563/contributions-of-dr-louis-pepper-dehner-to-the-art-of-cutaneous-pathology-the-first-pediatric-dermatopathologist
#15
Alejandro A Gru, M D Horacio Maluf
Dr. Louis "Pepper" Dehner has been one of the most influential surgical pathologists of the last century. Authoring more than 450 publications, he is the premier modern pediatric pathologist. Perhaps, an area that he is less recognized and in which we would like to describe his contributions, is his role as a creator of the art of pediatric dermatopathology. Dr. Dehner has had at least 50 major publications describing, discovering, and orienting the discipline in the fields of fibrohistiocytic disorders of childhood, vascular tumors, and histiocytosis among many others...
September 5, 2016: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/27793410/pathology-of-the-liver-in-children-where-would-i-we-be-without-pepper
#16
Milton J Finegold
A tribute to Pepper's lasting contributions to Hepatopathology.
September 4, 2016: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/27514237/diagnostic-immunohistochemistry-through-rosai-coloured-glasses
#17
Paul E Swanson
Over the past three decades, Immunohistochemistry has materially changed the practice of diagnostic surgical pathology. Foundational observations in this field were critical to a reasoned assessment of both the risks and opportunities that immunohistochemistry afforded the surgical pathologist, and our current practice draws heavily on those early assessments. As we collectively look to and acknowledge those who recognized the value of this technique and who helped guide its development as a companion to (not a replacement for) histomorphologic evaluation, we are drawn to those whose mastery of detail and ability to draw common patterns from seemingly unrelated phenomena helped define the diagnostic power of immunohistochemistry...
September 2016: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/27453172/mediastinal-pathology-and-the-contributions-of-dr-juan-rosai
#18
REVIEW
Mark R Wick
Dr. Juan Rosai is one of the most prolific contributors to the literature on mediastinal pathology, and he has added steadily to that body of work over a 50-year period. Rosai has written several landmark articles in this topical area, including articles on thymic epithelial lesions, mediastinal neuroendocrine tumors, mediastinal lymphoma and other hematopoietic lesions, thymolipoma, thymoliposarcoma, mediastinal solitary fibrous tumor, intrathymic langerhans-cell histiocytosis, mediastinal germ cell neoplasms, and multilocular thymic cyst...
September 2016: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/27372744/introduction
#19
EDITORIAL
Mark R Wick
No abstract text is available yet for this article.
September 2016: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/27370529/rosai-dorfman-disease-familiar-yet-enigmatic
#20
REVIEW
Steven H Kroft
No abstract text is available yet for this article.
September 2016: Seminars in Diagnostic Pathology
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