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Seminars in Diagnostic Pathology

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https://www.readbyqxmd.com/read/30360941/-what-the-world-social-and-political-concrete-and-mental-really-needs-is-not-new-things-but-the-old-things-made-new-ethel-m-dell
#1
EDITORIAL
Mark R Wick
No abstract text is available yet for this article.
October 17, 2018: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/30409459/diagnostic-histochemistry-in-hepatic-pathology
#2
REVIEW
Julia C Iezzoni
Histochemistry has an important, continuing role in the current assessment of hepatic biopsies and resection specimens. The evaluation of connective tissue elements in the liver can be accomplished with such methods as the Masson trichrome, Snook reticulin, Vierhoff van Gieson, orcein, and Victoria blue stains. The results contribute to the diagnosis of acute and chronic hepatitis, submassive necrosis, venous outflow obstruction, steatohepatitis, and cirrhosis. Fat stains done on frozen sections of liver tissue are routinely performed in the evaluation of donor liver allograft biopsies...
October 16, 2018: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/30366793/diagnostic-histochemistry-in-medical-diseases-of-the-kidney
#3
REVIEW
Helen P Cathro, Steven S Shen, Luan D Truong
The value of histochemical analysis in the diagnosis of medical renal diseases has long been known, and its use continues currently. Depending on the particular disorder in question, a variety of "special" stains may be applied to renal biopsies. These include the periodic acid-Schiff, Masson trichrome, Jones, von Kossa, Verhoeff-van Gieson, Congo Red, and toluidine blue methods, among others. This review considers the application of such techniques in the assessment of vascular, glomerular, and tubulointerstitial lesions of the kidney...
October 16, 2018: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/30366792/diagnostic-histochemistry-of-soft-tissue-lesions
#4
REVIEW
Elizabeth A Montgomery
Histochemical methods (HM) were, at one time, extensively used in all facets of anatomic pathology, including analysis of soft tissue lesions. That situation has changed with the advent of other adjunctive procedures, but HM still do contribute meaningfully to the evaluation of several tumefactive conditions in the soft tissue. This brief review considers selected neoplastic, quasineoplastic, and pseudoneoplastic lesions in that category, with emphasis on their histochemical properties.
October 16, 2018: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/30366791/diagnostic-histochemistry-a-historical-perspective
#5
REVIEW
Mark R Wick
Histochemistry has a history which, in some ways, goes back to ancient times. The desire for humans to understand the workings of their bodies, and the roles that various chemicals have in them, is long-standing. This review considers the evolution of histochemistry and cytochemistry as scientific disciplines, culminating in the pairing of those techniques with basic biochemistry. They have served as the bases for a synthesis of microscopy, chemistry, immunology, and molecular biology, particularly in the practice of anatomic pathology...
October 16, 2018: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/30366790/histochemistry-in-the-diagnosis-of-non-neoplastic-gastrointestinal-disorders
#6
REVIEW
Patrick L Fitzgibbons
The alimentary tract serves as host to a large number of diseases. In the non-neoplastic group of disorders, conventional histochemistry continues to play an important diagnostic role. It is particularly important in recognizing specific infectious diseases, such as Helicobacter gastritis, Whipple disease, intestinal tuberculosis and other forms of mycobacteriosis, malakoplakia, intestinal spirochetosis, fungal enteritides, amebiasis, cryptosporidiosis, isosporiasis, and microsporidiosis. Those conditions and their histochemical properties are discussed in this review, along with the use of histochemistry in the characterization of structural gastrointestinal disorders...
October 16, 2018: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/30262157/reprint-of-the-pathology-of-pulmonary-sarcoidosis-update
#7
YanLing Ma, Anthony Gal, Michael Koss
Sarcoidosis is a multi-system disease of unknown etiology, usually affecting the respiratory tract and other organs, and is characterized by the formation of nonnecrotizing epithelioid granulomas. The diagnosis depends on a combination of a typical clinicoradiological presentation, the finding of nonnecrotizing epithelioid granulomas in a tissue biopsy, and exclusion of other possible diseases, especially those of infectious etiology. The granulomas contain epithelioid cells, giant cells, CD4+ T cells in their center, and CD8+ T lymphocytes and B lymphocytes at their periphery...
September 24, 2018: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/30249370/reprint-of-nonspecific-interstitial-pneumonia-pathologic-features-and-clinical-implications
#8
Jeffrey L Myers
Nonspecific interstitial pneumonia (NSIP) is a form of chronic interstitial pneumonia that should be separated from the other idiopathic interstitial pneumonias, including most importantly, usual interstitial pneumonia (UIP). Diagnosis is predicated on identification of characteristic findings in a surgical lung biopsy in the appropriate clinical and radiological context. Affected patients may have a variety of underlying or associated conditions, although most have a form of idiopathic lung disease associated with a more favorable prognosis than UIP/idiopathic pulmonary fibrosis (IPF)...
September 8, 2018: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/30249369/reprint-of-unusual-non-neoplastic-lesions-of-the-lung
#9
Cesar A Moran, Saul Suster
Many nonneoplastic conditions that may affect the lung are in reality rare or unusual manifestations of metabolic processes, inflammatory conditions, or unknown etiology. Because of their rarity, they can often be confused with malignant neoplasms. Familiarity with these conditions not only will expedite further treatment for these patients but also will avoid the process of more tests or unnecessary surgical procedures. The nomenclature for some of those conditions is still controversial. The clinical outcome of these conditions can be quite variable, with some patients surviving a long number of years and others eventually succumbing to the disease...
September 8, 2018: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/30249368/reprint-of-pathologic-manifestations-of-immunoglobulin-ig-g4-related-lung-disease
#10
Eunhee S Yi, Hiroshi Sekiguchi, Tobias Peikert, Jay H Ryu, Thomas V Colby
Immunoglobulin(Ig)G4-related disease (IgG4-RD) is a fibroinflammatory condition that can affect virtually any organ and usually presents as tumefactive lesions involving multiple sites. Characteristic histopathology of IgG4-RD consists of dense lymphoplasmacytic infiltrate, fibrosis (often in storiform pattern), and obliterative phlebitis, accompanied by tissue infiltration of IgG4-positive plasma cells with or without elevation of serum IgG4 level. Despite a general similarity in the morphologic manifestations of IgG4-RD, site-specific unique morphologic features have been described in some organs including the lung...
September 8, 2018: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/30173882/pulmonary-disorders-that-are-potentially-associated-with-anti-neutrophilic-cytoplasmic-antibodies-a-brief-review
#11
REVIEW
Mark R Wick
Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis frequently manifests with involvement of the lungs and kidneys, and it also may affect other anatomic sites. This article presents the patterns of pulmonary injury in which ANCA-associated vasculitis is included in the differential diagnosis, with a discussion of antineutrophil cytoplasmic antibody testing methods. The histologic features of non-vasculitic, potentially-ANCA-associated pulmonary lesions are reviewed briefly as well.
August 24, 2018: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/30173880/the-utility-of-bronchoalveolar-lavage-in-the-evaluation-of-interstitial-lung-diseases-a-clinicopathological-perspective
#12
REVIEW
Houda Gharsalli, Mouna Mlika, Imen Sahnoun, Sonia Maalej, Leila Douik El Gharbi, Faouzi El Mezni
Bronchoalveolar lavage (BAL) is a noninvasive and well-tolerated procedure that is performed with a fiberoptic bronchoscope in the wedged position within a selected bronchopulmonary segment. After it was introduced to clinical practice, BAL rapidly gained acceptance in a large number of centers as a procedure that could be applied to the clinical evaluation of patients with various pulmonary disorders, especially the group of interstitial lung diseases (ILD). Cytological and flow cytometric analysis of BAL fluid in ILD is done with knowledge of the clinical presentation and radiological findings...
August 24, 2018: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/30173881/introduction
#13
EDITORIAL
Mona Mlika-Zorgati, Mark R Wick
No abstract text is available yet for this article.
August 16, 2018: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/30219281/interstitial-lung-disease-elementary-lesions-and-diagnosis
#14
REVIEW
Mona Mlika, Emna Braham, Faouzi Mezni
No abstract text is available yet for this article.
August 13, 2018: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/30172458/interstitial-lung-diseases-imaging-contribution-to-diagnosis-and-elementary-radiological-lesions
#15
REVIEW
Henda Neji, Monia Attia, Mariem Affes, Ines Baccouche, Khaoula Ben Miled-M'rad, Saoussen Hantous-Zannad
Interstitial pneumonias comprise a heterogeneous group of disorders in which a multidisciplinary approach is important for accuracy in diagnosis; indeed, one might say, even mandatory. The team of collaborators should include radiologists, because high resolution computed tomography (HRCT) of the thorax is is the first, and most of times, the only imaging examination to be prescribed after chest X-ray. . Elementary lesions of the interstitium can be accurately described with HRCT, inasmuch as lung windowing with sharp filtering in this technique reproduces the microscopic features of the lung...
August 10, 2018: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/30154023/pathologic-features-of-smoking-related-lung-diseases-with-emphasis-on-smoking-related-interstitial-fibrosis-and-a-consideration-of-differential-diagnoses
#16
REVIEW
Mark R Wick
Smoking-related interstitial fibrosis (SRIF) is frequently-seen and morphologically-distinctive finding in the lung tissue of cigarette smokers. It can be distinguished histologically from the idiopathic interstitial pneumonias and other causes of pulmonary interstitial fibrosis. SRIF is typified by dense thickening of the alveolar septa by thick collagen bundles with a hyalinized appearance, with the common admixture of bands of hyperplastic smooth muscle. Concomitant inflammation is minimal. SRIF predominates in the subpleural and centrilobular parenchyma, and is usually accompanied by the changes of centrilobular emphysema and respiratory bronchiolitis...
August 10, 2018: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/29705513/iatrogenic-lesions-preface
#17
EDITORIAL
Mark R Wick
No abstract text is available yet for this article.
July 2018: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/29631763/iatrogenic-pulmonary-lesions
#18
REVIEW
Anja C Roden, Philippe Camus
Treatment of patients often includes the administration of medications and sometimes radiation. While the intent is to treat an underlying condition, in some cases, adverse effects occur due to these agents. Most of these adverse effects are mild, however, some can be severe and life-threatening. Furthermore, while these effects are often reversible upon cessation of exposure, especially if the inciting agent is recognized and withdrawn early, others might be permanent or even progressing. Most common histopathologic findings in drug-induced interstitial lung disease include nonspecific interstitial pneumonia (cellular and/or fibrotic), organizing pneumonia with or without bronchiolitis, eosinophilic pneumonia, pulmonary edema, diffuse alveolar damage, hypersensitivity pneumonitis, granulomatous interstitial lung disease, chronic bronchiolitis, and pulmonary hemorrhage...
July 2018: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/29615296/reexamining-post-transplant-lymphoproliferative-disorders-newly-recognized-and-enigmatic-types
#19
REVIEW
Nadine Aguilera, Alejandro A Gru
Post-transplant lymphoproliferative disorders (PTLD) are a known risk for both solid organ transplant and stem cell transplant recipients. Overall transplant recipients have a six fold increase in risk for developing any kind of non-Hodgkin lymphoma and PTLDs occur in up to 10% of SOT recipients. Several new entities have been accepted or renamed in the 2018 update of the WHO classification of tumors of hematopoietic and lymphoid neoplasms, including florid follicular hyperplasia and extranodal marginal zone lymphomas of mucosa-associated lymphoid tissue (MALT-lymphoma) (excluding common locations such as stomach and salivary gland)...
July 2018: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/29576423/iatrogenic-pathology-of-the-urinary-bladder
#20
REVIEW
Antonio Lopez-Beltran, Rodolfo Montironi, Maria R Raspollini, Liang Cheng, George J Netto
Intravesical immunotherapy, chemotherapy, and neoadjuvant systemic chemotherapy are among the most frequent therapeutic procedures to treat malignancies of the urinary bladder. These treatment modalities produce reactive morphologic changes in the urothelium that can mimic urothelial carcinoma in situ, urothelial dysplasia or true invasive urothelial neoplasia. Mitomycin C used after transurethral resection of bladder tumor to reduce recurrences, BCG intravesical immunotherapy to treat high risk non-muscle invasive bladder cancer and urothelial carcinoma in situ, and platinum-based systemic chemotherapy to improve post-cystectomy disease-specific survival some of the causes of therapy related atypia in urinary bladder...
July 2018: Seminars in Diagnostic Pathology
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