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Journal of Clinical and Experimental Neuropsychology

Angela Deotto, Robyn Westmacott, Amanda Fuentes, Gabrielle deVeber, Mary Desrocher
INTRODUCTION: Current research suggests that pediatric stroke is associated with a reduction in intellectual functioning. However, less is known about academic achievement and the contribution of specific executive functions to math and literacy in this population. The current study investigates behavioral ratings of executive functioning and their relationship to math and spelling performance in children with a history of unilateral arterial ischemic stroke. METHOD: Thirty-two pediatric patients with stroke (Mage  = 9...
October 23, 2018: Journal of Clinical and Experimental Neuropsychology
Rivka Green, Christine Till, Hiba Al-Hakeem, Rob Cribbie, Martha M Téllez-Rojo, Erika Osorio, Howard Hu, Lourdes Schnaas
BACKGROUND: The Cambridge Neuropsychological Test Automated Battery (CANTAB) is a computerized tool used to measure cognitive function in diverse populations and is sensitive for assessing developmental changes in children. Although CANTAB has been used in several countries, its applicability in a Mexican child population is unknown. This study examined developmental trends on CANTAB in a large sample of urban Mexico City youth and tested the hypothesis that their performance would be similar to a large US normative sample...
October 18, 2018: Journal of Clinical and Experimental Neuropsychology
Ingvar Bergman, Kurt Johansson, Catarina Lundberg
INTRODUCTION: Neuropsychological assessment of cognitive change over time is often conducted in clinical settings, but whether neuropsychological change scores are influenced by physical health has, as far as we know, not been examined previously. METHOD: In a sample of 153 older Swedish adults (age range, 72-86 years), we evaluated the influence of common age-related diseases, terminal decline pathology, age, education, and gender, to provide (a) preliminary test-specific regression weights and 90% confidence intervals to assess significant change in performance after five years on tests of visual scanning, mental shifting, visual spatial ability, memory, reaction time, and selective attention, and (b) normative data for the Useful Field of View test (UFOV) from a single testing occasion...
October 18, 2018: Journal of Clinical and Experimental Neuropsychology
Naomi White, Larnee Flannery, Alice McClintock, Liana Machado
INTRODUCTION: Repeated cognitive assessment is frequently required to monitor changes in cognitive functioning in older adults, but studies of repeated computerized testing in this population are scarce. To provide new insight into retest effects this study examined within- and between-day performance shifts and test-retest reliability among healthy older adults for test scores from a computerized cognitive battery. METHOD: Thirty older men (65-71 years) completed the battery six times...
October 15, 2018: Journal of Clinical and Experimental Neuropsychology
Kelly A Mills, Kristyn Donohue, Aathman Swaminathan, Jeannie-Marie Leoutsakos, Gwenn Smith, Jason Brandt
BACKGROUND: Deep brain stimulation (DBS) is effective for treatment of motor complications of dopaminergic therapy in Parkinson's disease (PD) but occasionally has been associated with multidomain cognitive decline. Patient- and caregiver-reported cognitive decline are clinically meaningful and increasingly recognized as important to consider when evaluating therapeutic interventions for PD. OBJECTIVE: The objective was to assess presurgical neuropsychological and clinical factors associated with PD patient- and caregiver-reported cognitive decline in two or more domains after DBS...
October 8, 2018: Journal of Clinical and Experimental Neuropsychology
Masahiro Hirai, Takeshi Sakurada, Shin-Ichi Muramatsu
INTRODUCTION: Parkinson's disease is a progressive neurological disorder characterized by the preferential loss of dopaminergic neurons in the substantia nigra, which project to the striatum. The disease is characterized by prominent motor symptoms, which are its cardinal features. Consequently, Parkinson's disease has been primarily considered a disorder of movement. However, increasing evidence has indicated that Parkinson's disease affects not only the motor domain but also the cognitive domain...
September 10, 2018: Journal of Clinical and Experimental Neuropsychology
Christopher Malone, Rebecca G Deason, Rocco Palumbo, Nadine Heyworth, Michelle Tat, Andrew E Budson
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that presents predominantly with impairments in learning and memory. Patients with AD are also susceptible to false memories, a clinically relevant memory distortion where a patient remembers an incorrect memory that they believe to be true. The use of cognitive strategies to improve memory performance among patients with AD by reducing false memories has taken on added importance given the lack of disease-modifying agents for AD. However, existing evidence suggests that cognitive strategies to reduce false memories in patients with AD are of limited effectiveness, although these strategies may be useful at earlier stages of the disease...
September 4, 2018: Journal of Clinical and Experimental Neuropsychology
Rebecca G Deason, Jessica V Strong, Michelle J Tat, Nicholas R Simmons-Stern, Andrew E Budson
INTRODUCTION: Previous studies have found that music paired with lyrics at encoding may improve the memory performance of patients with mild Alzheimer's disease (AD). To further explore memory for different types of musical stimuli, the current study examined both implicit and explicit memory for music with and without lyrics compared to spoken lyrics. METHOD: In this mixed design, patients with probable mild AD (n = 15) and healthy older adults (n = 13) listened to auditory clips (song, instrumental, or spoken lyrics varied across three sessions) and then had their memory tested...
September 3, 2018: Journal of Clinical and Experimental Neuropsychology
Rayna B Hirst, Jessica Watson, Alexis S Rosen, Zoe Quittner
INTRODUCTION: Research evaluating the neuropsychological effects of cannabis has yielded mixed findings, with some studies finding cognitive deficits in cannabis users (primarily in learning and memory) and others finding no significant effects. It is important to understand how clinicians perceive this discrepancy in the empirical literature. However, no studies have assessed neuropsychologists' beliefs regarding the effects of cannabis on cognitive functioning. Thus, this study sought to evaluate how patient and cannabis-use factors influence neuropsychologists' perceptions of cannabis's cognitive effects...
August 20, 2018: Journal of Clinical and Experimental Neuropsychology
Victoria C Merritt, Alexandra L Clark, Scott F Sorg, Nicole D Evangelista, Madeleine L Werhane, Mark W Bondi, Dawn M Schiehser, Lisa Delano-Wood
INTRODUCTION: The purpose of this study was to investigate the effect of the apolipoprotein E (APOE) ε4 allele on neuropsychological functioning in military Veterans with a remote history of mild traumatic brain injury (mTBI). METHOD: This cross-sectional study included 99 Veterans (mTBI = 53; military controls, MC = 46) who underwent neuropsychological assessment and APOE genotyping. Three neurocognitive composite scores-memory (α = .84), speed (α = ...
August 20, 2018: Journal of Clinical and Experimental Neuropsychology
Andrew J Levine, Eileen Martin, Cynthia A Munro, Ned Sacktor, Steve Horvath, James T Becker
INTRODUCTION: HIV-associated neurocognitive disorders (HAND) are estimated to affect approximately 50% of infected individuals at any one time. Dispersion, a type of intraindividual variability in neurocognitive test performance, has been identified as a potential behavioral marker of HAND; however, the specificity of dispersion to HAND and how it is influenced by participant effort when taking neurocognitive tests remain unclear. METHOD: Data were analyzed from 996 (474 HIV-, 522 HIV+) men enrolled in the Multicenter AIDS Cohort Study (MACS)...
August 20, 2018: Journal of Clinical and Experimental Neuropsychology
Carla Ruis
INTRODUCTION: Historically, most studies about awake brain surgery have focused on language or motor functions. More recently, other cognitive functions have also been assessed. However, a clear overview of the neuropsychological tests or test paradigms that are used during such procedures is missing. The primary research question of this review is: What neuropsychological tests or paradigms are used during awake brain surgery? This review aims to give an extensive overview about the assessment of cognition during awake brain surgery...
December 2018: Journal of Clinical and Experimental Neuropsychology
Jeremy J Davis
INTRODUCTION: This study examined false positive rates on embedded performance validity tests (PVTs) in older adults grouped by cognitive status. METHOD: The research design involved secondary analysis of data from the National Alzheimer's Coordinating Center database. Participants (N = 22,688) were grouped by cognitive status: normal (n = 10,319), impaired (n = 1,194), amnestic or nonamnestic mild cognitive impairment (MCI; n = 5,414), and dementia (n = 5,761)...
December 2018: Journal of Clinical and Experimental Neuropsychology
Immanuel Babu Henry Samuel, Christopher Barkley, Susan E Marino, Chao Wang, Sahng-Min Han, Angela K Birnbaum, Jean E Cibula, Mingzhou Ding
INTRODUCTION: Topiramate (TPM), a frequently prescribed antiseizure medication, can cause severe cognitive side-effects. Though these side-effects have been studied behaviorally, the underlying neural mechanisms are unknown. In a double-blind, randomized, placebo-controlled, crossover study of TPM's impact on cognition, nine healthy volunteers completed three study sessions: a no-drug baseline session and two sessions during which they received either TPM or placebo. Electroencephalogram was recorded during each session while subjects performed a working-memory task with three memory-loads...
December 2018: Journal of Clinical and Experimental Neuropsychology
Aleksandra Mańkowska, Michał Harciarek, John B Williamson, Kenneth M Heilman
OBJECTIVES: Several studies have reported that positive emotions are primarily mediated by the left hemisphere and negative emotions by the right hemisphere. Since each hemisphere primarily allocates attention toward the contralateral hemispace, we wanted to learn how inducing a spatial attentional orienting bias to right and left egocentric hemispace might influence the recognition and perception of visually presented emotional scenes. METHOD: Participants were 42 healthy, right-handed young adults...
November 2018: Journal of Clinical and Experimental Neuropsychology
Kimberly D Mueller, Bruce Hermann, Jonilda Mecollari, Lyn S Turkstra
INTRODUCTION: The neuropsychological profile of people with mild cognitive impairment (MCI) and Alzheimer's disease (AD) dementia includes a history of decline in memory and other cognitive domains, including language. While language impairments have been well described in AD dementia, language features of MCI are less well understood. Connected speech and language analysis is the study of an individual's spoken discourse, usually elicited by a target stimulus, the results of which can facilitate understanding of how language deficits typical of MCI and AD dementia manifest in everyday communication...
November 2018: Journal of Clinical and Experimental Neuropsychology
Massimiliano Conson, Filippo Bianchini, Mario Quarantelli, Maddalena Boccia, Sara Salzano, Antonella Di Vita, Cecilia Guariglia
INTRODUCTION: Developmental topographical disorientation (DTD) is a lifelong condition in which affected individuals are selectively impaired in navigating space. Although it seems that DTD is widespread in the population, only a few cases have been studied from both a behavioral and a neuroimaging point of view. Here, we report a new case of DTD, never described previously, of a young woman (C.F.) showing a specific deficit in translating allocentrically coded information into egocentrically guided navigation, in presence of spared ability of constructing such representations...
November 2018: Journal of Clinical and Experimental Neuropsychology
Julio A Rodriguez, Damon G Lamb, Liliana Salazar, Lauren N Correa, Diana M Mosquera, Zared J Schwartz, Ronald A Cohen, Adam D Falchook, Kenneth M Heilman
Background-objectives: When vertical lines are positioned above or below the center of the page, line bisection deviates toward the center of the page, suggesting that the edges of the page distract the allocation of attention to the line. A letter-character line (LCL) bisection requires both global and focal attention, to identify the target letter closest to the line's center. If more focal and less global attention is allocated to a LCL, more global attentional resources may be available and inadvertently allocated to the page...
November 2018: Journal of Clinical and Experimental Neuropsychology
Jocelyne C Whitehead, Lingqian Li, Douglas A McQuiggan, Sara A Gambino, Malcolm A Binns, Jennifer D Ryan
INTRODUCTION: Preferential viewing of novel stimuli in the Visual Paired Comparison task has provided a useful marker of memory and medial temporal lobe function. We created a portable version of the VPC (P-VPC) and contrasted P-VPC metrics against the Montreal Cognitive Assessment (MoCA) in healthy adults, to assess the validity and reliability of the P-VPC as an indicator of memory function across age. A supplementary case series was conducted with individuals diagnosed with Alzheimer's disease (AD) and other dementias, to provide a preliminary illustration of the P-VPC's use as a measure in clinical populations...
November 2018: Journal of Clinical and Experimental Neuropsychology
Mathilde Sacher, Andrei-Cristian Tudorache, David Clarys, Mohamed Boudjarane, Lionel Landré, Wissam El-Hage
OBJECTIVES: Posttraumatic stress disorder (PTSD) has been consistently associated with episodic memory deficits. To some extent, these deficits could be related to an impairment of metamemory in individuals with PTSD. This research consequently aims at investigating prospective (feeling-of-knowing, FOK) and retrospective (confidence) metamemory judgments for episodic information in PTSD. METHOD: Twenty participants with PTSD and without depression were compared to 30 healthy comparison participants on metamemory judgments during an episodic memory task...
November 2018: Journal of Clinical and Experimental Neuropsychology
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